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Alan Permutt

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Kristen A Pickett; Ryan P Duncan; Gammon M Earhart; Tamara Hershey; Bess Marshall; Alex R Paciorkowski; M Alan Permutt
Balance impairment in individuals with Wolfram syndrome.
Tamara Hershey; Jonathan M Koller; Heather M Lugar; Alex R Paciorkowski; Dana Perantie; M Alan Permutt; Jerrel Rutlin; Joshua S Shimony; Sarah A Eisenstein
Early brain vulnerability in Wolfram syndrome.
Katsuya Tanabe; Yang Liu; Syed D Hasan; Sara C Martinez; Corentin Cras-Méneur; CM Welling; Ernesto Bernal-Mizrachi; Yukio Tanizawa; Christopher J Rhodes; Erik Zmuda; Tsonwin Hai; Nada A Abumrad; M Alan Permutt
Glucose and fatty acids synergize to promote B-cell apoptosis through activation of glycogen synthase kinase 3β independent of JNK activation.

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2012: Kristen A Pickett; Ryan P Duncan; Gammon M Earhart; Tamara Hershey; Bess Marshall; Alex R Paciorkowski; M Alan Permutt
Balance impairment in individuals with Wolfram syndrome.
Gait & posture 2012;36(3):619-24.
2012: Tamara Hershey; Jonathan M Koller; Heather M Lugar; Alex R Paciorkowski; Dana Perantie; M Alan Permutt; Jerrel Rutlin; Joshua S Shimony; Sarah A Eisenstein
Early brain vulnerability in Wolfram syndrome.
PloS one 2012;7(7):e40604.
2011: Katsuya Tanabe; Yang Liu; Syed D Hasan; Sara C Martinez; Corentin Cras-Méneur; CM Welling; Ernesto Bernal-Mizrachi; Yukio Tanizawa; Christopher J Rhodes; Erik Zmuda; Tsonwin Hai; Nada A Abumrad; M Alan Permutt
Glucose and fatty acids synergize to promote B-cell apoptosis through activation of glycogen synthase kinase 3β independent of JNK activation.
PloS one 2011;6(4):e18146.
2010: Y Liu; K Tanabe; D Baronnier; S Patel; James R Woodgett; Corentin Cras-Méneur; M Alan Permutt
Conditional ablation of Gsk-3β in islet beta cells results in expanded mass and resistance to fat feeding-induced diabetes in mice.
Diabetologia 2010;53(12):2600-10.
2010: Ernesto Bernal-Mizrachi; Corentin Cras-Méneur; Bo Ra Ye; James D Johnson; M Alan Permutt
Transgenic overexpression of active calcineurin in beta-cells results in decreased beta-cell mass and hyperglycemia.
PloS one 2010;5(8):e11969.
2010: Rosalind J Neuman; Jon Wasson; Gil Atzmon; Julio Wainstein; Yair Yerushalmi; Joseph Cohen; Nir Barzilai; Ilana Blech; Benjamin Glaser; M Alan Permutt
Gene-gene interactions lead to higher risk for development of type 2 diabetes in an Ashkenazi Jewish population.
PloS one 2010;5(3):e9903.
2009: Zvi Granot; Avital Swisa; Judith Magenheim; Miri Stolovich-Rain; Wakako Fujimoto; Elisabetta Manduchi; Takashi Miki; Jochen K Lennerz; Christian J Stoeckert; Oded Meyuhas; Susumu Seino; M Alan Permutt; Helen Piwnica-Worms; Nabeel Bardeesy; Yuval Dor
LKB1 regulates pancreatic beta cell size, polarity, and function.
Cell metabolism 2009;10(4):296-308.
2009: Corentin Cras-Méneur; Lin Li; Raphael Kopan; M Alan Permutt
Presenilins, Notch dose control the fate of pancreatic endocrine progenitors during a narrow developmental window.
Genes & development 2009;23(17):2088-101.
2008: Inês Barroso; Jian'an Luan; Eleanor Wheeler; Pamela Whittaker; Jon Wasson; Eleftheria Zeggini; Michael N Weedon; Sarah Hunt; Ranganath Venkatesh; Timothy M Frayling; Marcos Delgado; Rosalind J Neuman; Jinghua Zhao; Richard Sherva; Benjamin Glaser; Mark Walker; Graham A Hitman; Mark I McCarthy; Andrew T Hattersley; M Alan Permutt; Nicholas J Wareham; Panos Deloukas
Population-specific risk of type 2 diabetes conferred by HNF4A P2 promoter variants: a lesson for replication studies.
Diabetes 2008;57(11):3161-5.
2008: Latisha Love-Gregory; Richard Sherva; Lingwei Sun; Jon Wasson; Timothy Schappe; Alessandro Doria; Dabeeru C Rao; Steven C Hunt; Samuel Klein; Rosalind J Neuman; M Alan Permutt; Nada A Abumrad
Variants in the CD36 gene associate with the metabolic syndrome and high-density lipoprotein cholesterol.
Human molecular genetics 2008;17(11):1695-704.
2008: Z Liu; K Tanabe; Ernesto Bernal-Mizrachi; M Alan Permutt
Mice with beta cell overexpression of glycogen synthase kinase-3beta have reduced beta cell mass and proliferation.
Diabetologia 2008;51(4):623-31.
2008: Sara C Martinez; Katsuya Tanabe; Corentin Cras-Méneur; Nada A Abumrad; Ernesto Bernal-Mizrachi; M Alan Permutt
Inhibition of Foxo1 protects pancreatic islet beta-cells against fatty acid and endoplasmic reticulum stress-induced apoptosis.
Diabetes 2008;57(4):846-59.
2008: Jonathon Wasson; M Alan Permutt
Candidate gene studies reveal that the WFS1 gene joins the expanding list of novel type 2 diabetes genes.
Diabetologia 2008;51(3):391-3.
2008: Katsuya Tanabe; Zhonghao Liu; Satish Patel; Bradley Doble; Lin Li; Corentin Cras-Méneur; Sara C Martinez; CM Welling; Morris F White; Ernesto Bernal-Mizrachi; James R Woodgett; M Alan Permutt
Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance.
PLoS biology 2008;6(2):e37.
2007: Yiyong Zhou; Corentin Cras-Méneur; Mitsuru Ohsugi; Gary stormo; M Alan Permutt
A global approach to identify differentially expressed genes in cDNA (two-color) microarray experiments.
Bioinformatics (Oxford, England) 2007;23(16):2073-9.
2007: Manjinder S Sandhu; Michael Weedon; Katherine A Fawcett; Jon Wasson; Sally L Debenham; Allan Daly; Hana Lango; Timothy M Frayling; Rosalind J Neumann; Richard Sherva; Ilana Blech; Paul D P Pharoah; Colin N A Palmer; Charlotte Kimber; Roger Tavendale; Andrew D Morris; Mark I McCarthy; Mark Walker; Graham A Hitman; Benjamin Glaser; M Alan Permutt; Andrew T Hattersley; Nicholas J Wareham; Inês Barroso
Common variants in WFS1 confer risk of type 2 diabetes.
Nature genetics 2007;39(8):951-3.
2007: Latisha Love-Gregory; M Alan Permutt
HNF4A genetic variants: role in diabetes.
Current opinion in clinical nutrition and metabolic care 2007;10(4):397-402.
2006: James D Johnson; Ernesto Bernal-Mizrachi; Emilyn U Alejandro; Zhiqiang Han; Tatyana B Kalynyak; Hong Li; Jennifer L Beith; Julia Gross; Garth L Warnock; R Reid Townsend; M Alan Permutt; Kenneth S Polonsky
Insulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteome.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(51):19575-80.
2006: Sara C Martinez; Corentin Cras-Méneur; Ernesto Bernal-Mizrachi; M Alan Permutt
Glucose regulates Foxo1 through insulin receptor signaling in the pancreatic islet beta-cell.
Diabetes 2006;55(6):1581-91.
2005: Joseph C Koster; M Alan Permutt; Colin G Nichols
Diabetes and insulin secretion: the ATP-sensitive K+ channel (K ATP) connection.
Diabetes 2005;54(11):3065-72.
2005: A C Riggs; Ernesto Bernal-Mizrachi; Mitsuru Ohsugi; JC Wasson; Szabolcs Fatrai; CM Welling; J Murray; R E Schmidt; P L Herrera; M Alan Permutt
Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis.
Diabetologia 2005;48(11):2313-21.
2005: Kathryn A Moynihan; Andrew Grimm; Marie M Plueger; Ernesto Bernal-Mizrachi; Eric Ford; Corentin Cras-Méneur; M Alan Permutt; Shinichiro Imai
Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice.
Cell metabolism 2005;2(2):105-17.
2005: M Alan Permutt; Jonathon Wasson; Nancy Cox
Genetic epidemiology of diabetes.
The Journal of clinical investigation 2005;115(6):1431-9.
2005: Shanthi Srinivasan; Mitsuru Ohsugi; Zhonghao Liu; Szabolcs Fatrai; Ernesto Bernal-Mizrachi; M Alan Permutt
Endoplasmic reticulum stress-induced apoptosis is partly mediated by reduced insulin signaling through phosphatidylinositol 3-kinase/Akt and increased glycogen synthase kinase-3beta in mouse insulinoma cells.
Diabetes 2005;54(4):968-75.
2005: Mitsuru Ohsugi; Corentin Cras-Méneur; Yiyong Zhou; Ernesto Bernal-Mizrachi; James D Johnson; Dan S Luciani; Kenneth S Polonsky; M Alan Permutt
Reduced expression of the insulin receptor in mouse insulinoma (MIN6) cells reveals multiple roles of insulin signaling in gene expression, proliferation, insulin content, and secretion.
The Journal of biological chemistry 2005;280(6):4992-5003.
2004: Michael Weedon; Katharine R Owen; Beverley Shields; Graham A Hitman; Mark Walker; Mark I McCarthy; Latisha Love-Gregory; M Alan Permutt; Andrew T Hattersley; Timothy M Frayling
Common variants of the hepatocyte nuclear factor-4alpha P2 promoter are associated with type 2 diabetes in the U.K. population.
Diabetes 2004;53(11):3002-6.
2004: Ernesto Bernal-Mizrachi; Szabolcs Fatrai; James D Johnson; Mitsuru Ohsugi; Kenichi Otani; Zhiqiang Han; Kenneth S Polonsky; M Alan Permutt
Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells.
The Journal of clinical investigation 2004;114(7):928-36.
2004: Mitsuru Ohsugi; Corentin Cras-Méneur; Yiyong Zhou; Wesley Warren; Ernesto Bernal-Mizrachi; M Alan Permutt
Glucose and insulin treatment of insulinoma cells results in transcriptional regulation of a common set of genes.
Diabetes 2004;53(6):1496-508.
2004: Latisha Love-Gregory; Jonathon Wasson; Jiyan Ma; Carol H Jin; Benjamin Glaser; Brian K Suarez; M Alan Permutt
A common polymorphism in the upstream promoter region of the hepatocyte nuclear factor-4 alpha gene on chromosome 20q is associated with type 2 diabetes and appears to contribute to the evidence for linkage in an ashkenazi jewish population.
Diabetes 2004;53(4):1134-40.
2004: Corentin Cras-Méneur; H Inoue; Yiyong Zhou; Mitsuru Ohsugi; Ernesto Bernal-Mizrachi; D Pape; Sandra W Clifton; M Alan Permutt
An expression profile of human pancreatic islet mRNAs by Serial Analysis of Gene Expression (SAGE).
Diabetologia 2004;47(2):284-99.
2003: Abdullah A Osman; Mitsuyoshi Saito; Carol Makepeace; M Alan Permutt; Paul H Schlesinger; Mike Mueckler
Wolframin expression induces novel ion channel activity in endoplasmic reticulum membranes and increases intracellular calcium.
The Journal of biological chemistry 2003;278(52):52755-62.
2003: Klaus kaestner; Catherine S Lee; L Marie Scearce; John E Brestelli; Athanasios Arsenlis; Phillip Phuc Le; Kristen A Lantz; Jonathan Crabtree; Angel Pizarro; Joan Mazzarelli; Deborah F Pinney; Steve Fischer; Elisabetta Manduchi; Christian J Stoeckert; Gérard Gradwohl; Sandra W Clifton; Juliana R Brown; Hiroshi Inoue; Corentin Cras-Méneur; M Alan Permutt
Transcriptional program of the endocrine pancreas in mice and humans.
Diabetes 2003;52(7):1604-10.
2003: Latisha Love-Gregory; J Wasson; J Lin; Gary Skolnick; Brian K Suarez; M Alan Permutt
E23K single nucleotide polymorphism in the islet ATP-sensitive potassium channel gene (Kir6.2) contributes as much to the risk of Type II diabetes in Caucasians as the PPARgamma Pro12Ala variant.
Diabetologia 2003;46(1):136-7.
2003: Ernesto Bernal-Mizrachi; Corentin Cras-Méneur; Mitsuru Ohsugi; M Alan Permutt
Gene expression profiling in islet biology and diabetes research.
Diabetes/metabolism research and reviews 2003;19(1):32-42.
2002: Ernesto Bernal-Mizrachi; Wu Wen; Michael Shornick; M Alan Permutt
Activation of nuclear factor-kappaB by depolarization and Ca(2+) influx in MIN6 insulinoma cells.
Diabetes 2002;51 Suppl 3():S484-8.
2002: M Alan Permutt; Jonathon Wasson; Latisha Love-Gregory; Jiyan Ma; Gary Skolnick; Brian K Suarez; Jennifer Lin; Benjamin Glaser
Searching for type 2 diabetes genes on chromosome 20.
Diabetes 2002;51 Suppl 3():S308-15.
2002: Shanthi Srinivasan; Ernesto Bernal-Mizrachi; Mitsuru Ohsugi; M Alan Permutt
Glucose promotes pancreatic islet beta-cell survival through a PI 3-kinase/Akt-signaling pathway.
American journal of physiology. Endocrinology and metabolism 2002;283(4):E784-93.
2002: L Marie Scearce; John E Brestelli; Shannon McWeeney; Catherine S Lee; Joan Mazzarelli; Deborah F Pinney; Angel Pizarro; Christian J Stoeckert; Sandra W Clifton; M Alan Permutt; Juliana Brown; Douglas A Melton; Klaus kaestner
Functional genomics of the endocrine pancreas: the pancreas clone set and PancChip, new resources for diabetes research.
Diabetes 2002;51(7):1997-2004.
2002: Jonathon Wasson; Gary Skolnick; Latisha Love-Gregory; M Alan Permutt
Assessing allele frequencies of single nucleotide polymorphisms in DNA pools by pyrosequencing technology.
BioTechniques 2002;32(5):1144-6, 1148, 1150 passim.
2001: Ernesto Bernal-Mizrachi; Wu Wen; S Stahlhut; CM Welling; M Alan Permutt
Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia.
The Journal of clinical investigation 2001;108(11):1631-8.
2001: Ernesto Bernal-Mizrachi; Wu Wen; S Srinivasan; A Klenk; D Cohen; M Alan Permutt
Activation of Elk-1, an Ets transcription factor, by glucose and EGF treatment of insulinoma cells.
American journal of physiology. Endocrinology and metabolism 2001;281(6):E1286-99.
2001: H Chen; S Jawahar; Y Qian; Q Duong; G Chan; A Parker; J M Meyer; K J Moore; S Chayen; D J Gross; B Glaser; M Alan Permutt; Lloyd D Fricker
Missense polymorphism in the human carboxypeptidase E gene alters enzymatic activity.
Human mutation 2001;18(2):120-31.
2001: A Matsubara; JC Wasson; S S Donelan; CM Welling; B Glaser; M Alan Permutt
Isolation and characterization of the human AKT1 gene, identification of 13 single nucleotide polymorphisms (SNPs), and their lack of association with Type II diabetes.
Diabetologia 2001;44(7):910-3.
2001: Burton M Wice; Ernesto Bernal-Mizrachi; M Alan Permutt
Glucose and other insulin secretagogues induce, rather than inhibit, expression of Id-1 and Id-3 in pancreatic islet beta cells.
Diabetologia 2001;44(4):453-63.
2001: M Alan Permutt; JC Wasson; B K Suarez; J Lin; J Thomas; J Meyer; Steve Lewitzky; J S Rennich; A Parker; LJ Duprat; S Maruti; S Chayen; B Glaser
A genome scan for type 2 diabetes susceptibility loci in a genetically isolated population.
Diabetes 2001;50(3):681-5.
2001: Adda Grimberg; Robert J Ferry; Andrea Kelly; S Koo-McCoy; Kenneth S Polonsky; B Glaser; M Alan Permutt; Lydia Aguilar-Bryan; D Stafford; Paul S Thornton; L Baker; Charles A Stanley
Dysregulation of insulin secretion in children with congenital hyperinsulinism due to sulfonylurea receptor mutations.
Diabetes 2001;50(2):322-8.
2000: M Alan Permutt; Ernesto Bernal-Mizrachi; H Inoue
Calpain 10: the first positional cloning of a gene for type 2 diabetes?
The Journal of clinical investigation 2000;106(7):819-21.
2000: Ernesto Bernal-Mizrachi; Burton M Wice; H Inoue; M Alan Permutt
Activation of serum response factor in the depolarization induction of Egr-1 transcription in pancreatic islet beta-cells.
The Journal of biological chemistry 2000;275(33):25681-9.
1999: Benjamin Glaser; J Furth; Charles A Stanley; L Baker; Paul S Thornton; Heddy Landau; M Alan Permutt
Intragenic single nucleotide polymorphism haplotype analysis of SUR1 mutations in familial hyperinsulinism.
Human mutation 1999;14(1):23-9.
1998: El Habib Hani; Philippe Boutin; Emmanuelle Durand; H Inoue; M Alan Permutt; Gilberto Velho; philippe froguel
Missense mutations in the pancreatic islet beta cell inwardly rectifying K+ channel gene (KIR6.2/BIR): a meta-analysis suggests a role in the polygenic basis of Type II diabetes mellitus in Caucasians.
Diabetologia 1998;41(12):1511-5.
1998: Fergus Ryan; D Devaney; C Joyce; A Nestorowicz; M Alan Permutt; Benjamin Glaser; David Barton; Paul S Thornton
Hyperinsulinism: molecular aetiology of focal disease.
Archives of disease in childhood 1998;79(5):445-7.
1998: K Kalidas; JC Wasson; B Glaser; J M Meyer; LJ Duprat; M F White; M Alan Permutt
Mapping of the human insulin receptor substrate-2 gene, identification of a linked polymorphic marker and linkage analysis in families with Type II diabetes: no evidence for a major susceptibility role.
Diabetologia 1998;41(11):1389-91.
1998: H Inoue; Yukio Tanizawa; JC Wasson; PS Behn; K Kalidas; Ernesto Bernal-Mizrachi; Mike Mueckler; H Marshall; H Donis-Keller; P Crock; D Rogers; M Mikuni; H Kumashiro; K Higashi; G Sobue; Yoshitomo Oka; M Alan Permutt
A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome).
Nature genetics 1998;20(2):143-8.
1998: T Tao; JC Wasson; Ernesto Bernal-Mizrachi; PS Behn; S Chayen; LJ Duprat; J Meyer; B Glaser; M Alan Permutt
Isolation and characterization of the human PAX4 gene.
Diabetes 1998;47(10):1650-3.
1998: Show-Ling Shyng; T Ferrigni; J B Shepard; A Nestorowicz; Benjamin Glaser; M Alan Permutt; Colin G Nichols
Functional analyses of novel mutations in the sulfonylurea receptor 1 associated with persistent hyperinsulinemic hypoglycemia of infancy.
Diabetes 1998;47(7):1145-51.
1998: A Nestorowicz; Benjamin Glaser; B A Wilson; Show-Ling Shyng; Colin G Nichols; Charles A Stanley; Paul S Thornton; M Alan Permutt
Genetic heterogeneity in familial hyperinsulinism.
Human molecular genetics 1998;7(7):1119-28.
1998: PS Behn; JC Wasson; S Chayen; I Smolovitch; J Thomas; B Glaser; M Alan Permutt
Hepatocyte nuclear factor 1alpha coding mutations are an uncommon contributor to early-onset type 2 diabetes in Ashkenazi Jews.
Diabetes 1998;47(6):967-9.
1998: Torben Hansen; Søren M Echwald; Lars Hansen; AM Møller; Katrine Almind; JO Clausen; Søren A Urhammer; H Inoue; Jorge Ferrer; J Bryan; Lydia Aguilar-Bryan; M Alan Permutt; Oluf Pedersen
Decreased tolbutamide-stimulated insulin secretion in healthy subjects with sequence variants in the high-affinity sulfonylurea receptor gene.
Diabetes 1998;47(4):598-605.
1998: Yasuharu Ohta; Yukio Tanizawa; H Inoue; T Hosaka; K Ueda; Akira Matsutani; VP Repunte; Masashi Yamada; Yoshihisa Kurachi; J Bryan; Lydia Aguilar-Bryan; M Alan Permutt; Yoshitomo Oka
Identification and functional analysis of sulfonylurea receptor 1 variants in Japanese patients with NIDDM.
Diabetes 1998;47(3):476-81.
1998: Benjamin Glaser; P Kesavan; M Heyman; E Davis; A Cuesta; Adina Buchs; Charles A Stanley; Paul S Thornton; M Alan Permutt; Franz M Matschinsky; KC Herold
Familial hyperinsulinism caused by an activating glucokinase mutation.
The New England journal of medicine 1998;338(4):226-30.
1998: M Alan Permutt; K Chiu; J Ferrer; Benjamin Glaser; H Inoue; A Nestorowicz; Charles A Stanley; Y Tanizawa
Genetics of type II diabetes.
Recent progress in hormone research 1998;53():201-16.
1998: Paul S Thornton; MS Satin-Smith; KC Herold; Benjamin Glaser; K C Chiu; A Nestorowicz; M Alan Permutt; L Baker; Charles A Stanley
Familial hyperinsulinism with apparent autosomal dominant inheritance: clinical and genetic differences from the autosomal recessive variant.
The Journal of pediatrics 1998;132(1):9-14.
1997: C A Iannotti; H Inoue; E Bernal; M Aoki; L Liu; H Donis-Keller; Michael S German; M Alan Permutt
Identification of a human LMX1 (LMX1.1)-related gene, LMX1.2: tissue-specific expression and linkage mapping on chromosome 9.
Genomics 1997;46(3):520-4.
1997: A Nestorowicz; N Inagaki; T Gonoi; K P Schoor; B A Wilson; Benjamin Glaser; Heddy Landau; Charles A Stanley; Paul S Thornton; S Seino; M Alan Permutt
A nonsense mutation in the inward rectifier potassium channel gene, Kir6.2, is associated with familial hyperinsulinism.
Diabetes 1997;46(11):1743-8.
1997: Stephan Francke; Karine Clement; Christian Dina; H Inoue; PS Behn; Vincent Vatin; Arnaud Basdevant; Bernard Guy-Grand; M Alan Permutt; philippe froguel; J Hager
Genetic studies of the leptin receptor gene in morbidly obese French Caucasian families.
Human genetics 1997;100(5-6):491-6.
1997: Nathalie Vionnet; El Habib Hani; S Lesage; Anne Philippi; J Hager; M Varret; M Stoffel; Y Tanizawa; K C Chiu; B Glaser; M Alan Permutt; Philippe Passa; F Demenais; philippe froguel
Genetics of NIDDM in France: studies with 19 candidate genes in affected sib pairs.
Diabetes 1997;46(6):1062-8.
1997: El Habib Hani; Karine Clément; Gilberto Velho; Nathalie Vionnet; J Hager; Anne Philippi; Christian Dina; H Inoue; M Alan Permutt; A Basdevant; M North; F Demenais; Bernard Guy-Grand; philippe froguel
Genetic studies of the sulfonylurea receptor gene locus in NIDDM and in morbid obesity among French Caucasians.
Diabetes 1997;46(4):688-94.
1997: H Inoue; J Ferrer; M Warren-Perry; Y Zhang; H Millns; RC Turner; Steven C Elbein; Carol Hampe; Brian K Suarez; N Inagaki; S Seino; M Alan Permutt
Sequence variants in the pancreatic islet beta-cell inwardly rectifying K+ channel Kir6.2 (Bir) gene: identification and lack of role in Caucasian patients with NIDDM.
Diabetes 1997;46(3):502-7.
1997: J Ferrer; JC Wasson; K D Schoor; Mike Mueckler; H Donis-Keller; M Alan Permutt
Mapping novel pancreatic islet genes to human chromosomes.
Diabetes 1997;46(3):386-92.
1996: A Nestorowicz; B A Wilson; K P Schoor; H Inoue; B Glaser; Heddy Landau; Charles A Stanley; Paul S Thornton; JP Clement; Joseph Bryan; Lydia Aguilar-Bryan; M Alan Permutt
Mutations in the sulonylurea receptor gene are associated with familial hyperinsulinism in Ashkenazi Jews.
Human molecular genetics 1996;5(11):1813-22.
1996: J Ferrer; JC Wasson; L Salkoff; M Alan Permutt
Cloning of human pancreatic islet large conductance Ca(2+)-activated K+ channel (hSlo) cDNAs: evidence for high levels of expression in pancreatic islets and identification of a flanking genetic marker.
Diabetologia 1996;39(8):891-8.
1996: Colin G Nichols; Show-Ling Shyng; A Nestorowicz; B Glaser; JP Clement; María Tinaquero; Lydia Aguilar-Bryan; M Alan Permutt; Joseph Bryan
Adenosine diphosphate as an intracellular regulator of insulin secretion.
Science (New York, N.Y.) 1996;272(5269):1785-7.
1996: H Inoue; A C Riggs; Yukio Tanizawa; K Ueda; A Kuwano; L Liu; H Donis-Keller; M Alan Permutt
Isolation, characterization, and chromosomal mapping of the human insulin promoter factor 1 (IPF-1) gene.
Diabetes 1996;45(6):789-94.
1996: Yukio Tanizawa; A Matsubara; K Ueda; H Katagiri; A Kuwano; J Ferrer; M Alan Permutt; Yoshitomo Oka
A human pancreatic islet inwardly rectifying potassium channel: cDNA cloning, determination of the genomic structure and genetic variations in Japanese NIDDM patients.
Diabetologia 1996;39(4):447-52.
1996: J Ferrer; M Aoki; P Behn; A Nestorowicz; A Riggs; M Alan Permutt
Mitochondrial glycerol-3-phosphate dehydrogenase. Cloning of an alternatively spliced human islet-cell cDNA, tissue distribution, physical mapping, and identification of a polymorphic genetic marker.
Diabetes 1996;45(2):262-6.
1995: Y Liang; P Kesavan; L Q Wang; Kevin D Niswender; Y Tanizawa; M Alan Permutt; Mark Magnuson; Franz M Matschinsky
Variable effects of maturity-onset-diabetes-of-youth (MODY)-associated glucokinase mutations on substrate interactions and stability of the enzyme.
The Biochemical journal 1995;309 ( Pt 1)():167-73.
1995: A C Riggs; Yukio Tanizawa; M Aoki; JC Wasson; J Ferrer; D U Rabin; M Vaxillaire; philippe froguel; M Alan Permutt
Characterization of the LIM/homeodomain gene islet-1 and single nucleotide screening in NIDDM.
Diabetes 1995;44(6):689-94.
1994: B Glaser; R Anker; K C Chiu; H Donis-Keller; M Alan Permutt
Dinucleotide repeat polymorphism at the human CCKBR locus.
Human molecular genetics 1994;3(11):2081.
1994: Mike Mueckler; M Kruse; M Strube; A C Riggs; K C Chiu; M Alan Permutt
A mutation in the Glut2 glucose transporter gene of a diabetic patient abolishes transport activity.
The Journal of biological chemistry 1994;269(27):17765-7.
1994: Yukio Tanizawa; A C Riggs; Samuel Dagogo-Jack; M Vaxillaire; philippe froguel; L Liu; H Donis-Keller; M Alan Permutt
Isolation of the human LIM/homeodomain gene islet-1 and identification of a simple sequence repeat polymorphism [corrected].
Diabetes 1994;43(7):935-41.
1994: Yukio Tanizawa; A C Riggs; Steven C Elbein; A Whelan; H Donis-Keller; M Alan Permutt
Human glucagon-like peptide-1 receptor gene in NIDDM. Identification and use of simple sequence repeat polymorphisms in genetic analysis.
Diabetes 1994;43(6):752-7.
1994: Yukio Tanizawa; A C Riggs; K C Chiu; R C Janssen; D S Bell; R P Go; J M Roseman; R T Acton; M Alan Permutt
Variability of the pancreatic islet beta cell/liver (GLUT 2) glucose transporter gene in NIDDM patients.
Diabetologia 1994;37(4):420-7.
1994: Steven C Elbein; M Hoffman; H Qin; K Chiu; Yukio Tanizawa; M Alan Permutt
Molecular screening of the glucokinase gene in familial type 2 (non-insulin-dependent) diabetes mellitus.
Diabetologia 1994;37(2):182-7.
1994: K C Chiu; Rodney C P Go; M Aoki; A C Riggs; Yukio Tanizawa; R T Acton; D S Bell; R L Goldenberg; J M Roseman; M Alan Permutt
Glucokinase gene in gestational diabetes mellitus: population association study and molecular scanning.
Diabetologia 1994;37(1):104-10.
1993: Franz M Matschinsky; Y Liang; P Kesavan; L Wang; P Froguel; G Velho; D Cohen; M Alan Permutt; Y Tanizawa; Thomas L Jetton
Glucokinase as pancreatic beta cell glucose sensor and diabetes gene.
The Journal of clinical investigation 1993;92(5):2092-8.
1993: J S Dillon; Yukio Tanizawa; M B Wheeler; X H Leng; B B Ligon; D U Rabin; H Yoo-Warren; M Alan Permutt; A E Boyd
Cloning and functional expression of the human glucagon-like peptide-1 (GLP-1) receptor.
Endocrinology 1993;133(4):1907-10.
1993: K Noda; Akira Matsutani; Yukio Tanizawa; R Neuman; T Kaneko; M Alan Permutt; K Kaku
Polymorphic microsatellite repeat markers at the glucokinase gene locus are positively associated with NIDDM in Japanese.
Diabetes 1993;42(8):1147-52.
1993: Yukio Tanizawa; K C Chiu; M A Province; R Morgan; D R Owens; A Rees; M Alan Permutt
Two microsatellite repeat polymorphisms flanking opposite ends of the human glucokinase gene: use in haplotype analysis of Welsh Caucasians with type 2 (non-insulin-dependent) diabetes mellitus.
Diabetologia 1993;36(5):409-13.
1993: K C Chiu; Yukio Tanizawa; M Alan Permutt
Glucokinase gene variants in the common form of NIDDM.
Diabetes 1993;42(4):579-82.
1993: K C Chiu; Yukio Tanizawa; M Alan Permutt
Non-sense mutation of glucokinase gene.
Lancet 1993;341(8841):385-6.
1993: Steven C Elbein; M Hoffman; K Chiu; Yukio Tanizawa; M Alan Permutt
Linkage analysis of the glucokinase locus in familial type 2 (non-insulin-dependent) diabetic pedigrees.
Diabetologia 1993;36(2):141-5.
1992: Steven C Elbein; M D Hoffman; A Matsutani; M Alan Permutt
Linkage analysis of GLUT1 (HepG2) and GLUT2 (liver/islet) genes in familial NIDDM.
Diabetes 1992;41(12):1660-7.
1992: Yukio Tanizawa; Akira Matsutani; K C Chiu; M Alan Permutt
Human glucokinase gene: isolation, structural characterization, and identification of a microsatellite repeat polymorphism.
Molecular endocrinology (Baltimore, Md.) 1992;6(7):1070-81.
1992: L Koranyi; Yukio Tanizawa; L Penicaud; N Atef; J Girard; M Alan Permutt
Developmental regulation of amylin and insulin-gene expression in lean (Fa/Fa) and obese (fa/fa) Zucker rats.
Diabetes 1992;41(6):685-90.
1992: L Olansky; R Janssen; C Welling; M Alan Permutt
Variability of the insulin gene in American blacks with NIDDM. Analysis by single-strand conformational polymorphisms.
Diabetes 1992;41(6):742-9.
1992: A T Hattersley; RC Turner; M Alan Permutt; P Patel; Yukio Tanizawa; K C Chiu; S O'Rahilly; P J Watkins; james wainscoat
Linkage of type 2 diabetes to the glucokinase gene.
Lancet 1992;339(8805):1307-10.
1992: L Olansky; C Welling; S Giddings; S Adler; R Bourey; G Dowse; S Serjeantson; P Zimmet; M Alan Permutt
A variant insulin promoter in non-insulin-dependent diabetes mellitus.
The Journal of clinical investigation 1992;89(5):1596-602.
1992: Akira Matsutani; R Janssen; H Donis-Keller; M Alan Permutt
A polymorphic (CA)n repeat element maps the human glucokinase gene (GCK) to chromosome 7p.
Genomics 1992;12(2):319-25.
1992: L Koranyi; D E James; Edward Kraegen; M Alan Permutt
Feedback inhibition of insulin gene expression by insulin.
The Journal of clinical investigation 1992;89(2):432-6.
1991: L I Koranyi; R E Bourey; H Vuorinen-Markkola; Veikko Koivisto; Mike Mueckler; M Alan Permutt; Hannele Yki-Järvinen
Level of skeletal muscle glucose transporter protein correlates with insulin-stimulated whole body glucose disposal in man.
Diabetologia 1991;34(10):763-5.
1991: Yukio Tanizawa; L I Koranyi; C M Welling; M Alan Permutt
Human liver glucokinase gene: cloning and sequence determination of two alternatively spliced cDNAs.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(16):7294-7.
1991: L Koranyi; R E Bourey; D James; Mike Mueckler; F T Fiedorek; M Alan Permutt
Glucose transporter gene expression in rat brain: Pretranslational changes associated with chronic insulin-induced hypoglycemia, fasting, and diabetes.
Molecular and cellular neurosciences 1991;2(3):244-52.
1991: L I Koranyi; R E Bourey; C A Slentz; John O Holloszy; M Alan Permutt
Coordinate reduction of rat pancreatic islet glucokinase and proinsulin mRNA by exercise training.
Diabetes 1991;40(3):401-4.
1990: A Matsutani; L Koranyi; N Cox; M Alan Permutt
Polymorphisms of GLUT2 and GLUT4 genes. Use in evaluation of genetic susceptibility to NIDDM in blacks.
Diabetes 1990;39(12):1534-42.
1990: M Alan Permutt
Genetics of NIDDM.
Diabetes care 1990;13(11):1150-3.
1990: E J Henriksen; R E Bourey; K J Rodnick; L Koranyi; M Alan Permutt; John O Holloszy
Glucose transporter protein content and glucose transport capacity in rat skeletal muscles.
The American journal of physiology 1990;259(4 Pt 1):E593-8.
1990: R E Bourey; L Koranyi; D E James; Mike Mueckler; M Alan Permutt
Effects of altered glucose homeostasis on glucose transporter expression in skeletal muscle of the rat.
The Journal of clinical investigation 1990;86(2):542-7.
1990: L Koranyi; D James; Mike Mueckler; M Alan Permutt
Glucose transporter levels in spontaneously obese (db/db) insulin-resistant mice.
The Journal of clinical investigation 1990;85(3):962-7.
1990: M Alan Permutt; S C Elbein
Insulin gene in diabetes. Analysis through RFLP.
Diabetes care 1990;13(3):364-74.
1990: K Kaku; Akira Matsutani; M Mueckler; M Alan Permutt
Polymorphisms of HepG2/erythrocyte glucose-transporter gene. Linkage relationships and implications for genetic analysis of NIDDM.
Diabetes 1990;39(1):49-56.
1989: L Koranyi; M Alan Permutt; J M Chirgwin; S J Giddings
Proinsulin I and II gene expression in inbred mouse strains.
Molecular endocrinology (Baltimore, Md.) 1989;3(11):1895-902.
1989: M Alan Permutt; L Koranyi; K Keller; P E Lacy; D W Scharp; Mike Mueckler
Cloning and functional expression of a human pancreatic islet glucose-transporter cDNA.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(22):8688-92.
1989: K Kaku; J McGill; M Province; M Alan Permutt
A single major gene controls most of the difference in susceptibility to streptozotocin-induced diabetes between C57BL/6J and C3H/HeJ mice.
Diabetologia 1989;32(10):716-23.
1989: K Kaku; M Province; M Alan Permutt
Genetic analysis of obesity-induced diabetes associated with a limited capacity to synthesize insulin in C57BL/KS mice: evidence for polygenic control.
Diabetologia 1989;32(9):636-43.
1989: F T Fiedorek; M Alan Permutt
Proinsulin mRNA levels in fasting and fed ADX rats: evidence for an indirect effect of glucocorticoids.
The American journal of physiology 1989;256(2 Pt 1):E303-8.
1988: K Kaku; F T Fiedorek; M Province; M Alan Permutt
Genetic analysis of glucose tolerance in inbred mouse strains. Evidence for polygenic control.
Diabetes 1988;37(6):707-13.
1987: M J Orland; M Alan Permutt
Genetic susceptibility to diabetes in inbred strains of mice: measurements of proinsulin mRNA and response to dexamethasone.
Diabetologia 1987;30(12):934-9.
1985: S J Giddings; J Chirgwin; M Alan Permutt
Evaluation of rat insulin messenger RNA in pancreatic and extrapancreatic tissues.
Diabetologia 1985;28(6):343-7.
1985: S J Giddings; J M Chirgwin; M Alan Permutt
Glucose regulated insulin biosynthesis in isolated rat pancreatic islets is accompanied by changes in proinsulin mRNA.
Diabetes research (Edinburgh, Scotland) 1985;2(2):71-5.
1984: M Alan Permutt; J Chirgwin; Peter Rotwein; S Giddings
Insulin gene structure and function: a review of studies using recombinant DNA methodology.
Diabetes care 1984;7(4):386-94.
1984: M Alan Permutt; K Kakita; P Malinas; I Karl; S Bonner-Weir; G Weir; S J Giddings
An in vivo analysis of pancreatic protein and insulin biosynthesis in a rat model for non-insulin-dependent diabetes.
The Journal of clinical investigation 1984;73(5):1344-50.
1983: S J Giddings; Peter Rotwein; J M Chirgwin; D Scharp; M Alan Permutt
Analysis of insulin gene expression in human pancreas.
Diabetes 1983;32(8):777-80.
1983: K Kakita; S J Giddings; Peter Rotwein; M Alan Permutt
Insulin gene expression in the developing rat pancreas.
Diabetes 1983;32(8):691-6.
1982: S J Giddings; J Chirgwin; M Alan Permutt
Effects of glucose on proinsulin messenger RNA in rats in vivo.
Diabetes 1982;31(7):624-9.
1982: K Kakita; S Giddings; M Alan Permutt
Biosynthesis of rat insulins I and II: evidence for differential expression of the two genes.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(9):2803-7.
1982: Peter Rotwein; S J Giddings; M Alan Permutt
Diagnosis and management of hypoglycemic disorders in adults.
Special topics in endocrinology and metabolism 1982;3():87-115.
1981: S J Giddings; J Chirgwin; M Alan Permutt
The effects of fasting and feeding on preproinsulin messenger RNA in rats.
The Journal of clinical investigation 1981;67(4):952-60.