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John Pernow

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Alexey Shemyakin; Peter Svenarud; Arnar Rafnsson; Magnus Settergren; Felix Böhm; Christian Jung; Oskar Kövamees; John Pernow
Arginase inhibition improves endothelial function in patients with coronary artery disease and type 2 diabetes mellitus.
Marina Basalay; Gareth L Ackland; Veronika Barsukevich; Alexander V Gourine; Svetlana Mastitskaya; Alexander Mrochek; John Pernow; Per-Ove Sjöquist; Andrey Gourine
Remote ischaemic pre- and delayed postconditioning - similar degree of cardioprotection but distinct mechanisms.
Christian Jung; Lars Rydén; Nawsad Saleh; Peder Sörensson; Håkan Arheden; John Pernow
Effects of myocardial postconditioning on the recruitment of endothelial progenitor cells.

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2012: Alexey Shemyakin; Peter Svenarud; Arnar Rafnsson; Magnus Settergren; Felix Böhm; Christian Jung; Oskar Kövamees; John Pernow
Arginase inhibition improves endothelial function in patients with coronary artery disease and type 2 diabetes mellitus.
Circulation 2012;126(25):2943-50.
2012: Marina Basalay; Gareth L Ackland; Veronika Barsukevich; Alexander V Gourine; Svetlana Mastitskaya; Alexander Mrochek; John Pernow; Per-Ove Sjöquist; Andrey Gourine
Remote ischaemic pre- and delayed postconditioning - similar degree of cardioprotection but distinct mechanisms.
Experimental physiology 2012;97(8):908-17.
2012: Christian Jung; Lars Rydén; Nawsad Saleh; Peder Sörensson; Håkan Arheden; John Pernow
Effects of myocardial postconditioning on the recruitment of endothelial progenitor cells.
Journal of interventional cardiology 2012;25(2):103-10.
2012: Christian Jung; Lars Rydén; Nawsad Saleh; Peder Sörensson; Håkan Arheden; John Pernow
Circulating endothelial and platelet derived microparticles reflect the size of myocardium at risk in patients with ST-elevation myocardial infarction.
Atherosclerosis 2012;221(1):226-31.
2012: Adrian T Gonon; Christian Jung; Abram Katz; Jon O Lundberg; Alexey Shemyakin; Per-Ove Sjöquist; Håkan Westerblad; John Pernow
Local arginase inhibition during early reperfusion mediates cardioprotection via increased nitric oxide production.
PloS one 2012;7(7):e42038.
2011: Asa Sandin; Markus Dagnell; Adrian T Gonon; John Pernow; Verena Stangl; Pontus Aspenström; Kai Kappert; Arne Ostman
Hypoxia followed by re-oxygenation induces oxidation of tyrosine phosphatases.
Cellular signalling 2011;23(5):820-6.
2010: Peder Sörensson; Nawzad Saleh; Frederic Bouvier; Felix Böhm; Magnus Settergren; Kenneth Caidahl; Per Tornvall; Håkan Arheden; Lars Rydén; John Pernow
Effect of postconditioning on infarct size in patients with ST elevation myocardial infarction.
Heart (British Cardiac Society) 2010;96(21):1710-5.
2010: Christian Jung; Arnar Rafnsson; Alexey Shemyakin; Felix Böhm; John Pernow
Different subpopulations of endothelial progenitor cells and circulating apoptotic progenitor cells in patients with vascular disease and diabetes.
International journal of cardiology 2010;143(3):368-72.
2010: Alexey Shemyakin; Firoozeh Salehzadeh; Felix Böhm; Lubna Al-Khalili; Adrian T Gonon; Henrik Wagner; Suad Efendic; Anna Krook; John Pernow
Regulation of glucose uptake by endothelin-1 in human skeletal muscle in vivo and in vitro.
The Journal of clinical endocrinology and metabolism 2010;95(5):2359-66.
2009: Magnus Settergren; F Böhm; L Rydén; John Pernow; M Kalani
Lipid lowering versus pleiotropic effects of statins on skin microvascular function in patients with dysglycaemia and coronary artery disease.
Journal of internal medicine 2009;266(5):492-8.
2009: David Nathanson; Ozlem Erdogdu; John Pernow; Qimin Zhang; Thomas Nyström
Endothelial dysfunction induced by triglycerides is not restored by exenatide in rat conduit arteries ex vivo.
Regulatory peptides 2009;157(1-3):8-13.
2009: Rickard E Malmström; Magnus Settergren; Felix Böhm; John Pernow; Paul Hjemdahl
No effect of lipid lowering on platelet activity in patients with coronary artery disease and type 2 diabetes or impaired glucose tolerance.
Thrombosis and haemostasis 2009;101(1):157-64.
2008: Felix Böhm; Jens Jensen; Bertil Svane; Magnus Settergren; John Pernow
Intracoronary endothelin receptor blockade improves endothelial function in patients with coronary artery disease.
Canadian journal of physiology and pharmacology 2008;86(11):745-51.
2008: Majid Kalani; John Pernow; Joakim Bragd; Gun Jörneskog
Improved peripheral perfusion during endothelin--a receptor blockade in patients with type 2 diabetes and critical limb ischemia.
Diabetes care 2008;31(7):e56.
2008: Magnus Settergren; Felix Böhm; Lars Rydén; John Pernow
Cholesterol lowering is more important than pleiotropic effects of statins for endothelial function in patients with dysglycaemia and coronary artery disease.
European heart journal 2008;29(14):1753-60.
2008: Adrian T Gonon; Ulrika widegren; Aliaksandr Bulhak; Firoozeh Salehzadeh; Jonas Persson; Per-Ove Sjöquist; John Pernow
Adiponectin protects against myocardial ischaemia-reperfusion injury via AMP-activated protein kinase, Akt, and nitric oxide.
Cardiovascular research 2008;78(1):116-22.
2008: Magnus Settergren; John Pernow; Kerstin Brismar; Gun Jörneskog; Majid Kalani
Endothelin-A receptor blockade increases nutritive skin capillary circulation in patients with type 2 diabetes and microangiopathy.
Journal of vascular research 2008;45(4):295-302.
2007: Felix Böhm; John Pernow
The importance of endothelin-1 for vascular dysfunction in cardiovascular disease.
Cardiovascular research 2007;76(1):8-18.
2007: Fausto Labruto; John Pernow; Jangning Yang; Jarle Vaage; Guro Valen
Small skin burn injury reduces cardiac tolerance to ischemia via a tumor necrosis factor alpha-dependent pathway.
Burns : journal of the International Society for Burn Injuries 2007;33(5):606-12.
2007: Aliaksandr Bulhak; Joy Roy; Ulf Hedin; Per-Ove Sjöquist; John Pernow
Cardioprotective effect of rosuvastatin in vivo is dependent on inhibition of geranylgeranyl pyrophosphate and altered RhoA membrane translocation.
American journal of physiology. Heart and circulatory physiology 2007;292(6):H3158-63.
2007: Gunvor Ahlborg; Alexey Shemyakin; Felix Böhm; Adrian T Gonon; John Pernow
Dual endothelin receptor blockade acutely improves insulin sensitivity in obese patients with insulin resistance and coronary artery disease.
Diabetes care 2007;30(3):591-6.
2007: Felix Böhm; Magnus Settergren; John Pernow
Vitamin C blocks vascular dysfunction and release of interleukin-6 induced by endothelin-1 in humans in vivo.
Atherosclerosis 2007;190(2):408-15.
2007: Adrian T Gonon; Aliaksandr Bulhak; Fausto Labruto; Per-Ove Sjöquist; John Pernow
Cardioprotection mediated by rosiglitazone, a peroxisome proliferator-activated receptor gamma ligand, in relation to nitric oxide.
Basic research in cardiology 2007;102(1):80-9.
2006: Aliaksandr Bulhak; Per-Ove Sjöquist; C-B Xu; L Edvinsson; John Pernow
Protection against myocardial ischaemia/reperfusion injury by PPAR-alpha activation is related to production of nitric oxide and endothelin-1.
Basic research in cardiology 2006;101(3):244-52.
2006: Alexey Shemyakin; Felix Böhm; Henrik Wagner; Suad Efendic; Peter Båvenholm; John Pernow
Enhanced endothelium-dependent vasodilatation by dual endothelin receptor blockade in individuals with insulin resistance.
Journal of cardiovascular pharmacology 2006;47(3):385-90.
2005: Gun Jörneskog; Majid Kalani; Jeanette Kuhl; Peter Båvenholm; Abram Katz; Gustaf Allerstrand; Michael Alvarsson; Suad Efendic; Claes-Göran Ostenson; John Pernow; John Wahren; Kerstin Brismar
Early microvascular dysfunction in healthy normal-weight males with heredity for type 2 diabetes.
Diabetes care 2005;28(6):1495-7.
2005: Felix Böhm; Magnus Settergren; Adrian T Gonon; John Pernow
The endothelin-1 receptor antagonist bosentan protects against ischaemia/reperfusion-induced endothelial dysfunction in humans.
Clinical science (London, England : 1979) 2005;108(4):357-63.
2005: Felix Böhm; E Beltran; John Pernow
Endothelin receptor blockade improves endothelial function in atherosclerotic patients on angiotensin converting enzyme inhibition.
Journal of internal medicine 2005;257(3):263-71.
2005: Adrian T Gonon; Aliaksandr Bulhak; Anders Bröijersén; John Pernow
Cardioprotective effect of an endothelin receptor antagonist during ischaemia/reperfusion in the severely atherosclerotic mouse heart.
British journal of pharmacology 2005;144(6):860-6.
2005: Thomas Nyström; Adrian T Gonon; Ake Sjöholm; John Pernow
Glucagon-like peptide-1 relaxes rat conduit arteries via an endothelium-independent mechanism.
Regulatory peptides 2005;125(1-3):173-7.
2005: Aliaksandr Bulhak; Alexander V Gourine; Adrian T Gonon; Per-Ove Sjöquist; Guro Valen; John Pernow
Oral pre-treatment with rosuvastatin protects porcine myocardium from ischaemia/reperfusion injury via a mechanism related to nitric oxide but not to serum cholesterol level.
Acta physiologica Scandinavica 2005;183(2):151-9.
2005: Alexander V Gourine; Audrey I Molosh; Dmitry M Poputnikov; Aliaksandr Bulhak; Per-Ove Sjöquist; John Pernow
Endothelin-1 exerts a preconditioning-like cardioprotective effect against ischaemia/reperfusion injury via the ET(A) receptor and the mitochondrial K(ATP) channel in the rat in vivo.
British journal of pharmacology 2005;144(3):331-7.
2004: Thorvald Bjurö; Lars Gullestad; Knut Endresen; Margareta Nordlander; Anders Malm; Lena Höglund; Inger Wahlqvist; John Pernow
Evaluation of ST-segment changes during and after maximal exercise tests in one-, two- and three-vessel coronary artery disease.
Scandinavian cardiovascular journal : SCJ 2004;38(5):270-7.
2004: John Pernow
Endothelin in coronary artery disease.
Scandinavian cardiovascular journal : SCJ 2004;38(5):257-8.
2004: Adrian T Gonon; Deniz Erbas; Anders Bröijersén; Guro Valen; John Pernow
Nitric oxide mediates protective effect of endothelin receptor antagonism during myocardial ischemia and reperfusion.
American journal of physiology. Heart and circulatory physiology 2004;286(5):H1767-74.
2003: John Pernow; Felix Bohm; Emma Beltran; Adrian T Gonon
L-arginine protects from ischemia-reperfusion-induced endothelial dysfunction in humans in vivo.
Journal of applied physiology (Bethesda, Md. : 1985) 2003;95(6):2218-22.
2003: Bo-Lennart Johansson; John Wahren; John Pernow
C-peptide increases forearm blood flow in patients with type 1 diabetes via a nitric oxide-dependent mechanism.
American journal of physiology. Endocrinology and metabolism 2003;285(4):E864-70.
2003: Per Tornvall; John Pernow; Lars-Olof Hansson
[C-reactive protein potential risk factor for cardiovascular disease].
Läkartidningen 2003;100(35):2691-3.
2003: Lars Gullestad; T Bjurø; Lars Aaberge; T Apelland; Rita Skårdal; Elin Kjekshus; Margareta Nordlander; B Ablad; John Pernow
The effect of a neuropeptide Y Y1 receptor antagonist in patients with angina pectoris.
European heart journal 2003;24(12):1120-7.
2003: Pia Lundman; Maria J Eriksson; Angela Silveira; Lars-Olof Hansson; John Pernow; Carl-Göran Ericsson; Anders Hamsten; Per Tornvall
Relation of hypertriglyceridemia to plasma concentrations of biochemical markers of inflammation and endothelial activation (C-reactive protein, interleukin-6, soluble adhesion molecules, von Willebrand factor, and endothelin-1).
The American journal of cardiology 2003;91(9):1128-31.
2003: Felix Böhm; John Pernow; Jonas Lindström; Gunvor Ahlborg
ETA receptors mediate vasoconstriction, whereas ETB receptors clear endothelin-1 in the splanchnic and renal circulation of healthy men.
Clinical science (London, England : 1979) 2003;104(2):143-51.
2002: Bengt Ullman; John Pernow; Jan M Lundberg; Hans Aström; Lennart Bergfeldt
Cardiovascular effects and cardiopulmonary plasma gradients following intravenous infusion of neuropeptide Y in humans: negative dromotropic effect on atrioventricular node conduction.
Clinical science (London, England : 1979) 2002;103(6):535-42.
2002: Alexander V Gourine; Aliaksandr Bulhak; Adrian T Gonon; John Pernow; Per-Ove Sjöquist
Cardioprotective effect induced by brief exposure to nitric oxide before myocardial ischemia-reperfusion in vivo.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2002;7(3):210-6.
2002: Alexander V Gourine; John Pernow; Dmitry M Poputnikov; Per-Ove Sjöquist
Calcium antagonist clevidipine reduces myocardial reperfusion injury by a mechanism related to bradykinin and nitric oxide.
Journal of cardiovascular pharmacology 2002;40(4):564-70.
2002: Qing-Dong Wang; John Pernow; Per-Ove Sjöquist; Lars Rydén
Pharmacological possibilities for protection against myocardial reperfusion injury.
Cardiovascular research 2002;55(1):25-37.
2002: Shinichi Tokuno; Fei Chen; John Pernow; Jiahua Jiang; Guro Valen
Effects of spontaneous or induced brain ischemia on vessel reactivity: the role of inducible nitric oxide synthase.
Life sciences 2002;71(6):679-92.
2002: Felix Böhm; Gunvor Ahlborg; Bo-Lennart Johansson; Lars-Olof Hansson; John Pernow
Combined endothelin receptor blockade evokes enhanced vasodilatation in patients with atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(4):674-9.
2002: Felix Böhm; Gunvor Ahlborg; John Pernow
Endothelin-1 inhibits endothelium-dependent vasodilatation in the human forearm: reversal by ETA receptor blockade in patients with atherosclerosis.
Clinical science (London, England : 1979) 2002;102(3):321-7.
2002: Felix Böhm; John Pernow
Urotensin II evokes potent vasoconstriction in humans in vivo.
British journal of pharmacology 2002;135(1):25-7.
2002: Felix Böhm; Bo-Lennart Johansson; Ulf Hedin; Kjell Alving; John Pernow
Enhanced vasoconstrictor effect of big endothelin-1 in patients with atherosclerosis: relation to conversion to endothelin-1.
Atherosclerosis 2002;160(1):215-22.
2001: Pia Lundman; Per Tornvall; L Nilsson; John Pernow
A triglyceride-rich fat emulsion and free fatty acids but not very low density lipoproteins impair endothelium-dependent vasorelaxation.
Atherosclerosis 2001;159(1):35-41.
2001: Adrian T Gonon; Alexander V Gourine; R J M Middelveld; Kjell Alving; John Pernow
Limitation of infarct size and attenuation of myeloperoxidase activity by an endothelin A receptor antagonist following ischaemia and reperfusion.
Basic research in cardiology 2001;96(5):454-62.
2001: Alexander V Gourine; Adrian T Gonon; Per-Ove Sjöquist; John Pernow
Short-acting calcium antagonist clevidipine protects against reperfusion injury via local nitric oxide-related mechanisms in the jeopardised myocardium.
Cardiovascular research 2001;51(1):100-7.
2001: Alexander V Gourine; Adrian T Gonon; John Pernow
Involvement of nitric oxide in cardioprotective effect of endothelin receptor antagonist during ischemia-reperfusion.
American journal of physiology. Heart and circulatory physiology 2001;280(3):H1105-12.
2000: Jiahua Jiang; Guro Valen; Shinichi Tokuno; Peter Thorén; John Pernow
Endothelial dysfunction in atherosclerotic mice: improved relaxation by combined supplementation with L-arginine-tetrahydrobiopterin and enhanced vasoconstriction by endothelin.
British journal of pharmacology 2000;131(7):1255-61.
2000: John Pernow; Felix Böhm; Bo-Lennart Johansson; Ulf Hedin; Lars Rydén
Enhanced vasoconstrictor response to endothelin-B-receptor stimulation in patients with atherosclerosis.
Journal of cardiovascular pharmacology 2000;36(5 Suppl 1):S418-20.
2000: Adrian T Gonon; Alexander V Gourine; John Pernow
Cardioprotection from ischemia and reperfusion injury by an endothelin A-receptor antagonist in relation to nitric oxide production.
Journal of cardiovascular pharmacology 2000;36(3):405-12.
2000: Lars Gullestad; Bjorn Jorgensen; T Bjuro; John Pernow; Jan M Lundberg; C D Dota; Christian Hall; Svein Simonsen; B Ablad
Postexercise ischemia is associated with increased neuropeptide Y in patients with coronary artery disease.
Circulation 2000;102(9):987-93.
1999: John Pernow; Qing-Dong Wang
The role of the L-arginine/nitric oxide pathway in myocardial ischaemic and reperfusion injury.
Acta physiologica Scandinavica 1999;167(2):151-9.
1999: Jiahua Jiang; Peter Thorén; giuseppina caligiuri; Göran K Hansson; John Pernow
Enhanced phenylephrine-induced rhythmic activity in the atherosclerotic mouse aorta via an increase in opening of KCa channels: relation to Kv channels and nitric oxide.
British journal of pharmacology 1999;128(3):637-46.
1999: Bo-Lennart Johansson; John Pernow
C-peptide potentiates the vasoconstrictor effect of neuropeptide Y in insulin-dependent diabetic patients.
Acta physiologica Scandinavica 1999;165(1):39-44.
1998: Adrian T Gonon; Qing-Dong Wang; John Pernow
The endothelin A receptor antagonist LU 135252 protects the myocardium from neutrophil injury during ischaemia/reperfusion.
Cardiovascular research 1998;39(3):674-82.
1998: Qing-Dong Wang; Adrian T Gonon; M Shimizu; Per-Ove Sjöquist; John Pernow
Contribution of endothelin to the coronary vasoconstriction in the isolated rat heart induced by nitric oxide synthase inhibition.
Acta physiologica Scandinavica 1998;163(4):325-30.
1998: Adrian T Gonon; Qing-Dong Wang; M Shimizu; John Pernow
The novel non-peptide selective endothelin A receptor antagonist LU 135,252 protects against myocardial ischaemic and reperfusion injury in the pig.
Acta physiologica Scandinavica 1998;163(2):131-7.
1997: John Pernow; Jan M Lundberg
[Blockade of endothelin receptors in cardiovascular diseases. A possible therapeutic alternative in the future].
Läkartidningen 1997;94(12):1069-73.
1997: John Pernow; Qing-Dong Wang
Endothelin in myocardial ischaemia and reperfusion.
Cardiovascular research 1997;33(3):518-26.
1997: Qing-Dong Wang; E Morcos; P Wiklund; John Pernow
L-arginine enhances functional recovery and Ca(2+)-dependent nitric oxide synthase activity after ischemia and reperfusion in the rat heart.
Journal of cardiovascular pharmacology 1997;29(2):291-6.
1997: John Pernow; Gunvor Ahlborg; Jan M Lundberg; L Kaijser
Long-lasting coronary vasoconstrictor effects and myocardial uptake of endothelin-1 in humans.
Acta physiologica Scandinavica 1997;159(2):147-53.
1996: John Pernow; L Kaijser; J M Lundberg; G Ahlborg
Comparable potent coronary constrictor effects of endothelin-1 and big endothelin-1 in humans.
Circulation 1996;94(9):2077-82.
1996: X S Li; Y Uriuda; Qing-Dong Wang; R Norlander; Per-Ove Sjöquist; John Pernow
Role of L-arginine in preventing myocardial and endothelial injury following ischaemia/reperfusion in the rat isolated heart.
Acta physiologica Scandinavica 1996;156(1):37-44.
1995: Qing-Dong Wang; Y Uriuda; John Pernow; A Hemsén; Per-Ove Sjöquist; Lars Rydén
Myocardial release of endothelin (ET) and enhanced ET(A) receptor-mediated coronary vasoconstriction after coronary thrombosis and thrombolysis in pigs.
Journal of cardiovascular pharmacology 1995;26(5):770-6.
1995: X S Li; Qing-Dong Wang; John Pernow
Beneficial effects of the endothelin receptor antagonist bosentan on myocardial and endothelial injury following ischaemia/reperfusion in the rat.
European journal of pharmacology 1995;283(1-3):161-8.
1995: Qing-Dong Wang; X S Li; J M Lundberg; John Pernow
Protective effects of non-peptide endothelin receptor antagonist bosentan on myocardial ischaemic and reperfusion injury in the pig.
Cardiovascular research 1995;29(6):805-12.
1995: Qing-Dong Wang; X S Li; John Pernow
The nonpeptide endothelin receptor antagonist bosentan enhances myocardial recovery and endothelial function during reperfusion of the ischemic rat heart.
Journal of cardiovascular pharmacology 1995;26 Suppl 3():S445-7.
1995: Qing-Dong Wang; A Hemsén; X S Li; J M Lundberg; Y Uriuda; John Pernow
Local overflow and enhanced tissue content of endothelin following myocardial ischaemia and reperfusion in the pig: modulation by L-arginine.
Cardiovascular research 1995;29(1):44-9.
1994: Qing-Dong Wang; X S Li; John Pernow
Characterization of endothelin-1-induced vascular effects in the rat heart by using endothelin receptor antagonists.
European journal of pharmacology 1994;271(1):25-30.
1994: John Pernow; Y Uriuda; Qing-Dong Wang; X S Li; R Nordlander; L Rydeén
The protective effect of L-arginine on myocardial injury and endothelial function following ischaemia and reperfusion in the pig.
European heart journal 1994;15(12):1712-9.