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Markus Perola

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Finland

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Petri Tyynelä; Sirkka Goebeler; Erkki Ilveskoski; Terho Lehtimäki; Jussi Mikkelsson; Markus Perola; Pekka J Karhunen
Age-dependent interaction of apolipoprotein E gene with eastern birthplace in Finland affects severity of coronary atherosclerosis and risk of fatal myocardial infarction-Helsinki Sudden Death Study.
Jussi P Posti; Saku Ruohonen; Perttu Salo; Mika Scheinin; Daniel Kurnik; Mordechai Muszkat; Markus Perola; Gbenga G Sofowora; Charles Michael Stein; Laura Valve; Amir Snapir
A polymorphism in the protein kinase C gene PRKCB is associated with α2-adrenoceptor-mediated vasoconstriction.
Ida Surakka; Ann-Christine Syvänen; Peter M Visscher; John B Whitfield; Elisabeth Widén; Gonneke Willemsen; Dorret I Boomsma; Kaare Christensen; Eco J C De Geus; Mario Falchi; Jaakko Kaprio; Kirsten O Kyvik; Ulrika Liljedahl; Patrik K E Magnusson; Nicholas G Martin; Grant W Montgomery; Juha Muilu; Aarno Palotie; Nancy L Pedersen; Leena Peltonen; Markus Perola; Kirsi H Pietiläinen; Iffat Rahman; Taina Rantanen; Samuli Ripatti; Kaisa Silander; Thorkild I A Sørensen; Tim Spector
A genome-wide association study of monozygotic twin-pairs suggests a locus related to variability of serum high-density lipoprotein cholesterol.

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All Publications

2013: Petri Tyynelä; Sirkka Goebeler; Erkki Ilveskoski; Terho Lehtimäki; Jussi Mikkelsson; Markus Perola; Pekka J Karhunen
Age-dependent interaction of apolipoprotein E gene with eastern birthplace in Finland affects severity of coronary atherosclerosis and risk of fatal myocardial infarction-Helsinki Sudden Death Study.
Annals of medicine 2013;45(3):213-9.
2013: Jussi P Posti; Saku Ruohonen; Perttu Salo; Mika Scheinin; Daniel Kurnik; Mordechai Muszkat; Markus Perola; Gbenga G Sofowora; Charles Michael Stein; Laura Valve; Amir Snapir
A polymorphism in the protein kinase C gene PRKCB is associated with α2-adrenoceptor-mediated vasoconstriction.
Pharmacogenetics and genomics 2013;23(3):127-34.
2012: Ida Surakka; Ann-Christine Syvänen; Peter M Visscher; John B Whitfield; Elisabeth Widén; Gonneke Willemsen; Dorret I Boomsma; Kaare Christensen; Eco J C De Geus; Mario Falchi; Jaakko Kaprio; Kirsten O Kyvik; Ulrika Liljedahl; Patrik K E Magnusson; Nicholas G Martin; Grant W Montgomery; Juha Muilu; Aarno Palotie; Nancy L Pedersen; Leena Peltonen; Markus Perola; Kirsi H Pietiläinen; Iffat Rahman; Taina Rantanen; Samuli Ripatti; Kaisa Silander; Thorkild I A Sørensen; Tim Spector
A genome-wide association study of monozygotic twin-pairs suggests a locus related to variability of serum high-density lipoprotein cholesterol.
Twin research and human genetics : the official journal of the International Society for Twin Studies 2012;15(6):691-9.
2012: Jaakko Allonen; Tero Hiekkalinna; Maisa Lokki; Markku S Nieminen; Olavi Parkkonen; Markus Perola; Timo E Strandberg; Satu Vaara; Juha Sinisalo
Mortality rate increases steeply with nonadherence to statin therapy in patients with acute coronary syndrome.
Clinical cardiology 2012;35(11):E22-7.
2012: Satu Vaara; Jaakko Allonen; Marja-Liisa Lokki; Markku S Nieminen; Olavi Parkkonen; Markus Perola; Pirkko J Pussinen; Juha Sinisalo
Cohort Profile: the Corogene study.
International journal of epidemiology 2012;41(5):1265-71.
2012: Annukka Marjamaa; Christopher Newton-Cheh; Markku S Nieminen; Peter A Noseworthy; Christopher J O'Donnell; Lasse Oikarinen; Gina Peloso; Leena Peltonen; Markus Perola; Kimmo Porthan; Samuli Ripatti; Aki S Havulinna; Antti Jula; Kimmo Kontula; Lauri Toivonen; Matti Viitasalo; Veikko Salomaa
A common variant near the KCNJ2 gene is associated with T-peak to T-end interval.
Heart rhythm : the official journal of the Heart Rhythm Society 2012;9(7):1099-103.
2012: Outi Törnwall; Jaakko Kaprio; Kaisu Keskitalo-Vuokko; Markus Perola; Karri Silventoinen; Hely Tuorila
Genetic contribution to sour taste preference.
Appetite 2012;58(2):687-94.
2012: Annukka M Lahtinen; Christopher Newton-Cheh; Peter A Noseworthy; Markus Perola; Aki S Havulinna; Antti Jula; Pekka J Karhunen; Johannes Kettunen; Kimmo Kontula; Veikko Salomaa
Common genetic variants associated with sudden cardiac death: the FinSCDgen study.
PloS one 2012;7(7):e41675.
2011: Kaisu Keskitalo-Vuokko; Anu Loukola; Markus Perola; Janne Pitkaniemi; Samuli Ripatti; O Salminen; Veikko Salomaa; Arpo Aromaa; Ulla Broms; Markku Heliövaara; Jaakko Kaprio
Associations of nicotine intake measures with CHRN genes in Finnish smokers.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 2011;13(8):686-90.
2011: Antti Knaapila; Markus Perola; Richard J Rose; Karri Silventoinen; Ulla Broms; Jaakko Kaprio; Hely M Tuorila
Food neophobia in young adults: genetic architecture and relation to personality, pleasantness and use frequency of foods, and body mass index--a twin study.
Behavior genetics 2011;41(4):512-21.
2011: K Luotola; A Pietilä; T Zeller; Leena Moilanen; Mika Kähönen; Markku S Nieminen; Y Antero Kesäniemi; S Blankenberg; Antti Jula; Markus Perola; Veikko Salomaa
Associations between interleukin-1 (IL-1) gene variations or IL-1 receptor antagonist levels and the development of type 2 diabetes.
Journal of internal medicine 2011;269(3):322-32.
2011: Markus Perola
Genetics of human stature: Lessons from genome-wide association studies.
Hormone research in pædiatrics 2011;76 Suppl 3():10-1.
2011: Eloise Helena Kok; Teemu M. Luoto; Markus Perola; Mervi Alanne; Sirkka Goebeler; Hannu Haapasalo; Satu Haikonen; Mikko A Hurme; Karita Isotalo; Pekka J Karhunen
CRP gene variation affects early development of Alzheimer's disease-related plaques.
Journal of neuroinflammation 2011;8():96.
2010: Samuli Ripatti; Emmi Tikkanen; Marju Orho-Melander; Aki S Havulinna; Kaisa Silander; Amitabh Sharma; Candace Guiducci; Markus Perola; Antti Jula; Juha Sinisalo; Marja-Liisa Lokki; Markku S Nieminen; Olle Melander; Veikko Salomaa; Leena Peltonen; Sekar Kathiresan
A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses.
Lancet 2010;376(9750):1393-400.
2010: Kari Luotola; Arto Pietilä; Mervi Alanne; Timo Lanki; Britt-Marie Loo; Antti Jula; Markus Perola; Annette Peters; Tanja Zeller; Stefan Blankenberg; Veikko Salomaa
Genetic variation of the interleukin-1 family and nongenetic factors determining the interleukin-1 receptor antagonist phenotypes.
Metabolism: clinical and experimental 2010;59(10):1520-7.
2010: T Mölkänen; A Rostila; Eija Ruotsalainen; Mervi Alanne; Markus Perola; Asko Ilari Järvinen
Genetic polymorphism of the C-reactive protein (CRP) gene and a deep infection focus determine maximal serum CRP level in Staphylococcus aureus bacteremia.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 2010;29(9):1131-7.
2010: Petri Tyynelä; Sirkka Goebeler; Erkki Ilveskoski; Jussi Mikkelsson; Markus Perola; Markku Löytönen; Pekka J Karhunen
Birthplace in area with high coronary heart disease mortality predicts the severity of coronary atherosclerosis among middle-aged Finnish men who had migrated to capital area: the Helsinki sudden death study.
Annals of medicine 2010;42(4):286-95.
2010: Juha Kere; Samuli Ripatti; Markus Perola
[Genetics of multifactorial diseases].
Duodecim; lääketieteellinen aikakauskirja 2010;126(19):2305-10.
2010: Jyri J Virtaa; Tarja Järvenpää; Kauko Heikkilä; Markus Perola; Markku Koskenvuo; Ismo Räihä; Juha O Rinne; Jaakko Kaprio
Midlife alcohol consumption and later risk of cognitive impairment: a twin follow-up study.
Journal of Alzheimer's disease : JAD 2010;22(3):939-48.
2009: Kari Luotola; Rauni Pääkkönen; Mervi Alanne; Timo Lanki; Leena Moilanen; Ida Surakka; Arto Pietilä; Mika Kähönen; Markku S Nieminen; Y Antero Kesäniemi; Annette Peters; Antti Jula; Markus Perola; Veikko Salomaa
Association of variation in the interleukin-1 gene family with diabetes and glucose homeostasis.
The Journal of clinical endocrinology and metabolism 2009;94(11):4575-83.
2009: Kaisu Keskitalo; Ulla Broms; Markku Heliövaara; Samuli Ripatti; Ida Surakka; Markus Perola; Janne Pitkäniemi; Leena Peltonen; Arpo Aromaa; Jaakko Kaprio
Association of serum cotinine level with a cluster of three nicotinic acetylcholine receptor genes (CHRNA3/CHRNA5/CHRNB4) on chromosome 15.
Human molecular genetics 2009;18(20):4007-12.
2009: Brian P McEvoy; Grant W Montgomery; Allan F McRae; Samuli Ripatti; Markus Perola; Tim D Spector; Lynn Cherkas; Kourosh R Ahmadi; Dorret Boomsma; Gonneke Willemsen; Jouke-Jan Hottenga; Nancy L Pedersen; Patrik K E Magnusson; Kirsten Ohm Kyvik; Kaare Christensen; Jaakko Kaprio; Kauko Heikkilä; Aarno Palotie; Elisabeth Widen; Juha Muilu; Ann-Christine Syvänen; Ulrika Liljedahl; Orla Hardiman; Simon Cronin; Leena Peltonen; Nicholas G Martin; Peter M Visscher
Geographical structure and differential natural selection among North European populations.
Genome research 2009;19(5):804-14.
2009: Juha Karvanen; Kaisa Silander; Frank Kee; Laurence Tiret; Veikko Salomaa; Kari Kuulasmaa; Per-Gunnar Wiklund; Jarmo Virtamo; Olli Saarela; Claire Perret; Markus Perola; Leena Peltonen; Francois Cambien; Jeanette Erdmann; Nilesh J Samani; Heribert Schunkert; Alun Evans
The impact of newly identified loci on coronary heart disease, stroke and total mortality in the MORGAM prospective cohorts.
Genetic epidemiology 2009;33(3):237-46.
2009: Sampo Sammalisto; Tero Hiekkalinna; Karen Schwander; Sharon L R Kardia; Alan B Weder; Beatriz L Rodriguez; Alessandro Doria; Jennifer A Kelly; Gail R Bruner; John B Harley; Susan Redline; Emma K Larkin; Sanjay R Patel; Amy J H Ewan; James L Weber; Markus Perola; Leena Peltonen
Genome-wide linkage screen for stature and body mass index in 3.032 families: evidence for sex- and population-specific genetic effects.
European journal of human genetics : EJHG 2009;17(2):258-66.
2009: M M L Laaksonen; Terhi A Outila; M U M Karkkainen; V E Kemi; Hannu Rita; Markus Perola; L M Valsta; Christel Lamberg-Allardt
Associations of vitamin D receptor, calcium-sensing receptor and parathyroid hormone gene polymorphisms with calcium homeostasis and peripheral bone density in adult Finns.
Journal of nutrigenetics and nutrigenomics 2009;2(2):55-63.
2009: Mari Levula; Nina Airla; Niku Oksala; Jussi A Hernesniemi; Markku Pelto-Huikko; Juha-Pekka Salenius; Rainer Zeitlin; Otso Järvinen; Ari-Pekka J Huovila; Seppo T Nikkari; Olli Jaakkola; Erkki Ilveskoski; Jussi Mikkelsson; Markus Perola; Reijo Laaksonen; Leena Kytömäki; Juhani T Soini; Mika Kähönen; Jyrki Parkkinen; Pekka J Karhunen; Terho Lehtimäki
ADAM8 and its single nucleotide polymorphism 2662 T/G are associated with advanced atherosclerosis and fatal myocardial infarction: Tampere vascular study.
Annals of medicine 2009;41(7):497-507.
2009: Petri Tyynela; Sirkka Goebeler; Erkki Ilveskoski; Jussi Mikkelsson; Markus Perola; Markku Loytonen; Pekka J Karhunen
Birthplace predicts risk for prehospital sudden cardiac death in middle-aged men who migrated to metropolitan area: The Helsinki Sudden Death Study.
Annals of medicine 2009;41(1):57-65.
2008: Leena E Viiri; Keijo M Viiri; Erkki Ilveskoski; Heini Huhtala; Markku Mäki; Pentti J Tienari; Markus Perola; Terho Lehtimäki; Pekka J Karhunen
Interactions of functional apolipoprotein E gene promoter polymorphisms with smoking on aortic atherosclerosis.
Circulation. Cardiovascular genetics 2008;1(2):107-16.
2008: Antti Knaapila; Hely Tuorila; Kirsten O Kyvik; Margaret J Wright; Kaisu Keskitalo; Jonathan Hansen; Jaakko Kaprio; Markus Perola; Karri Silventoinen
Self-ratings of olfactory function reflect odor annoyance rather than olfactory acuity.
The Laryngoscope 2008;118(12):2212-7.
2008: Minna Pellikka; Lassi Narhi; Markus Perola; Antti Penttila; Pekka J Karhunen; Jussi Mikkelsson
Platelet GPIbalpha, GPIV and vWF polymorphisms and fatal pre-hospital MI among middle-aged men.
Journal of thrombosis and thrombolysis 2008;26(2):91-6.
2008: Antti Knaapila; Hely Tuorila; Karri Silventoinen; Margaret J Wright; Kirsten O Kyvik; Kaisu Keskitalo; Jonathan Hansen; Jaakko Kaprio; Markus Perola
Environmental effects exceed genetic effects on perceived intensity and pleasantness of several odors: a three-population twin study.
Behavior genetics 2008;38(5):484-92.
2008: Per E Lundmark; Ulrika Liljedahl; Dorret I Boomsma; Heikki Mannila; Nicholas G Martin; Aarno Palotie; Leena Peltonen; Markus Perola; Tim D Spector; Ann-Christine Syvänen
Evaluation of HapMap data in six populations of European descent.
European journal of human genetics : EJHG 2008;16(9):1142-50.
2008: Patrik K E Magnusson; Marcus Boman; Ulf de Faire; Markus Perola; Leena Peltonen; Nancy L Pedersen
Genome-wide search for QTLs for apolipoprotein A-I level in elderly Swedish DZ twins: evidence of female-specific locus on 15q11-13.
European journal of human genetics : EJHG 2008;16(9):1103-10.
2008: Kaisu Keskitalo; Hely Tuorila; Tim D Spector; Lynn F Cherkas; Antti Knaapila; Jaakko Kaprio; Karri Silventoinen; Markus Perola
The Three-Factor Eating Questionnaire, body mass index, and responses to sweet and salty fatty foods: a twin study of genetic and environmental associations.
The American journal of clinical nutrition 2008;88(2):263-71.
2008: Kristina M Tiainen; Markus Perola; Vuokko M Kovanen; Sarianna Sipilä; Katja A Tuononen; Kaisa Rikalainen; Markku A Kauppinen; Elisabeth I M Widen; Jaakko Kaprio; Taina Rantanen; Urho M Kujala
Genetics of maximal walking speed and skeletal muscle characteristics in older women.
Twin research and human genetics : the official journal of the International Society for Twin Studies 2008;11(3):321-34.
2008: Anu Loukola; U Broms; H Maunu; Elisabeth Widén; K Heikkilä; M Siivola; A Salo; M L Pergadia; E Nyman; Sampo Sammalisto; Markus Perola; A Agrawal; A C Heath; Nicholas G Martin; P A F Madden; Leena Peltonen; Jaakko Kaprio
Linkage of nicotine dependence and smoking behavior on 10q, 7q and 11p in twins with homogeneous genetic background.
The pharmacogenomics journal 2008;8(3):209-19.
2008: Kati Kristiansson; Erkki Ilveskoski; Terho Lehtimäki; Leena Peltonen; Markus Perola; Pekka J Karhunen
Association analysis of allelic variants of USF1 in coronary atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(5):983-9.
2008: Beben Benyamin; Markus Perola; Belinda K Cornes; Pamela Af Madden; Aarno Palotie; Dale R Nyholt; Grant W Montgomery; Leena Peltonen; Nicholas G Martin; Peter M Visscher
Within-family outliers: segregating alleles or environmental effects? A linkage analysis of height from 5815 sibling pairs.
European journal of human genetics : EJHG 2008;16(4):516-24.
2008: Kirsi Auro; K Kristiansson; Björn Zethelius; C Berne; Lars Lannfelt; Marja-Riitta Taskinen; Matti Jauhiainen; Markus Perola; Leena Peltonen; Ann-Christine Syvänen
USF1 gene variants contribute to metabolic traits in men in a longitudinal 32-year follow-up study.
Diabetologia 2008;51(3):464-72.
2008: Kaisu Keskitalo; Karri Silventoinen; Hely Tuorila; Markus Perola; Kirsi H Pietiläinen; Aila Rissanen; Jaakko Kaprio
Genetic and environmental contributions to food use patterns of young adult twins.
Physiology & behavior 2008;93(1-2):235-42.
2008: Kaisa Silander; Mervi Alanne; Kati Kristiansson; Olli Saarela; Samuli Ripatti; Kirsi Auro; Juha Karvanen; Sangita Kulathinal; Matti Niemelä; Pekka Ellonen; Erkki Vartiainen; Pekka Jousilahti; Janna Saarela; Kari Kuulasmaa; Alun Evans; Markus Perola; Veikko Salomaa; Leena Peltonen
Gender differences in genetic risk profiles for cardiovascular disease.
PloS one 2008;3(10):e3615.
2007: Kaisu Keskitalo; Hely Tuorila; Tim D Spector; Lynn F Cherkas; Antti Knaapila; Karri Silventoinen; Markus Perola
Same genetic components underlie different measures of sweet taste preference.
The American journal of clinical nutrition 2007;86(6):1663-9.
2007: Mervi Alanne; Kati Kristiansson; Kirsi Auro; Kaisa Silander; Kari Kuulasmaa; Leena Peltonen; Veikko Salomaa; Markus Perola
Variation in the selenoprotein S gene locus is associated with coronary heart disease and ischemic stroke in two independent Finnish cohorts.
Human genetics 2007;122(3-4):355-65.
2007: Nabil Sabri Enattah; Aimee Trudeau; Ville Pimenoff; Luigi Maiuri; Salvatore Auricchio; Luigi Greco; Mauro Rossi; Michael Lentze; J K Seo; Soheila Rahgozar; Insaf F Khalil; Michael Alifrangis; Sirajedin Natah; Leif Groop; Nael Shaat; Andrew Kozlov; Galina Verschubskaya; David Comas; Kazima B Bulayeva; S Qasim Mehdi; Joseph D Terwilliger; Timo Sahi; Erkki Savilahti; Markus Perola; Antti Sajantila; Irma Järvelä; Leena Peltonen
Evidence of still-ongoing convergence evolution of the lactase persistence T-13910 alleles in humans.
American journal of human genetics 2007;81(3):615-25.
2007: Antti Knaapila; Hely Tuorila; Karri Silventoinen; Kaisu Keskitalo; Mikko Kallela; Maija Wessman; Leena Peltonen; Lynn F Cherkas; Tim D Spector; Markus Perola
Food neophobia shows heritable variation in humans.
Physiology & behavior 2007;91(5):573-8.
2007: Kirsi Auro; Mervi Alanne; Kati Kristiansson; Kaisa Silander; Kari Kuulasmaa; Veikko Salomaa; Leena Peltonen; Markus Perola
Combined effects of thrombosis pathway gene variants predict cardiovascular events.
PLoS genetics 2007;3(7):e120.
2007: Kaisu Keskitalo; Antti Knaapila; Mikko Kallela; Aarno Palotie; Maija Wessman; Sampo Sammalisto; Leena Peltonen; Hely Tuorila; Markus Perola
Sweet taste preferences are partly genetically determined: identification of a trait locus on chromosome 16.
The American journal of clinical nutrition 2007;86(1):55-63.
2007: Markus Perola; Sampo Sammalisto; Tero Hiekkalinna; Nick G Martin; Peter M Visscher; Grant W Montgomery; Beben Benyamin; Jennifer R Harris; Dorret I Boomsma; Gonneke Willemsen; Jouke-Jan Hottenga; Kaare Christensen; Kirsten Ohm Kyvik; Thorkild I A Sørensen; Nancy L Pedersen; Patrik K E Magnusson; Tim D Spector; Elisabeth Widen; Karri Silventoinen; Jaakko Kaprio; Aarno Palotie; Leena Peltonen
Combined genome scans for body stature in 6,602 European twins: evidence for common Caucasian loci.
PLoS genetics 2007;3(6):e97.
2007: Yue-Mei Fan; Terho Lehtimäki; Riikka Rontu; Erkki Ilveskoski; Sirkka Goebeler; Olli A Kajander; Jussi Mikkelsson; Leena E Viiri; Markus Perola; Pekka J Karhunen
The hepatic lipase gene C-480T polymorphism in the development of early coronary atherosclerosis: the Helsinki Sudden Death Study.
European journal of clinical investigation 2007;37(6):472-7.
2007: Yue-Mei Fan; Terho Lehtimäki; Riikka Rontu; Erkki Ilveskoski; Sirkka Goebeler; Olli A Kajander; Jussi Mikkelsson; Markus Perola; Pekka J Karhunen
Age-dependent association between hepatic lipase gene C-480T polymorphism and the risk of pre-hospital sudden cardiac death: the Helsinki Sudden Death Study.
Atherosclerosis 2007;192(2):421-7.
2007: Antti Knaapila; Kaisu Keskitalo; Mikko Kallela; Maija Wessman; Sampo Sammalisto; Tero Hiekkalinna; Aarno Palotie; Leena Peltonen; Hely Tuorila; Markus Perola
Genetic component of identification, intensity and pleasantness of odours: a Finnish family study.
European journal of human genetics : EJHG 2007;15(5):596-602.
2006: Kati Komulainen; Mervi Alanne; Kirsi Auro; Riika Kilpikari; Päivi Pajukanta; Janna Saarela; Pekka Ellonen; Kaisa Salminen; Sangita Kulathinal; Kari Kuulasmaa; Kaisa Silander; Veikko Salomaa; Markus Perola; Leena Peltonen
Risk alleles of USF1 gene predict cardiovascular disease of women in two prospective studies.
PLoS genetics 2006;2(5):e69.
2006: Leena Peltonen; Markus Perola; Jussi Naukkarinen; Aarno Palotie
Lessons from studying monogenic disease for common disease.
Human molecular genetics 2006;15 Spec No 1():R67-74.
2006: Kirsi Auro; Kati Komulainen; Mervi Alanne; Kaisa Silander; Leena Peltonen; Markus Perola; Veikko Salomaa
Thrombomodulin gene polymorphisms and haplotypes and the risk of cardiovascular events: a prospective follow-up study.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(4):942-7.
2006: V Karhunen; H Forss; Sirkka Goebeler; H Huhtala; Erkki Ilveskoski; Olli A Kajander; Jussi Mikkelsson; Antti Penttilä; Markus Perola; Helena Ranta; J H Meurman; Pekka J Karhunen
Radiographic assessment of dental health in middle-aged men following sudden cardiac death.
Journal of dental research 2006;85(1):89-93.
2005: Sampo Sammalisto; Tero Hiekkalinna; Elina Suviolahti; K Sood; A Metzidis; Päivi Pajukanta; Heidi E Lilja; Aino Soro-Paavonen; Marja-Riitta Taskinen; Tiinamaija Tuomi; Peter Almgren; Marju Orho-Melander; L Groop; Leena Peltonen; Markus Perola
A male-specific quantitative trait locus on 1p21 controlling human stature.
Journal of medical genetics 2005;42(12):932-9.
2005: Kaisa Silander; Kati Komulainen; Pekka Ellonen; Minttu Jussila; Mervi Alanne; Minna Levander; Päivi Tainola; Kari Kuulasmaa; Veikko Salomaa; Markus Perola; Leena Peltonen; Janna Saarela
Evaluating whole genome amplification via multiply-primed rolling circle amplification for SNP genotyping of samples with low DNA yield.
Twin research and human genetics : the official journal of the International Society for Twin Studies 2005;8(4):368-75.
2005: Perttu J Pöllänen; Terho Lehtimäki; Jussi Mikkelsson; Erkki Ilveskoski; Tarja A Kunnas; Markus Perola; Antti Penttilä; Kari M Mattila; Seppo T Nikkari; Kirsi Syrjäkoski; Pekka J Karhunen
Matrix metalloproteinase3 and 9 gene promoter polymorphisms: joint action of two loci as a risk factor for coronary artery complicated plaques.
Atherosclerosis 2005;180(1):73-8.
2005: Jussi Mikkelsson; Markus Perola; Pekka J Karhunen
Genetics of platelet glycoprotein receptors: risk of thrombotic events and pharmacogenetic implications.
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 2005;11(2):113-25.
2005: Tero Hiekkalinna; Joseph D Terwilliger; Sampo Sammalisto; Leena Peltonen; Markus Perola
AUTOGSCAN: powerful tools for automated genome-wide linkage and linkage disequilibrium analysis.
Twin research and human genetics : the official journal of the International Society for Twin Studies 2005;8(1):16-21.
2005: Alun Evans; Veikko Salomaa; Sangita Kulathinal; Kjell Asplund; François Cambien; Marco Ferrario; Markus Perola; Leena Peltonen; Denis Shields; Hugh Tunstall-Pedoe; Kari Kuulasmaa
MORGAM (an international pooling of cardiovascular cohorts).
International journal of epidemiology 2005;34(1):21-7.
2004: Heidi E Lilja; Elina Suviolahti; Aino Soro-Paavonen; Tero Hiekkalinna; Aaron Day; Kenneth Lange; Eric Sobel; Marja-Riitta Taskinen; Leena Peltonen; Markus Perola; Päivi Pajukanta
Locus for quantitative HDL-cholesterol on chromosome 10q in Finnish families with dyslipidemia.
Journal of lipid research 2004;45(10):1876-84.
2004: Elina Ollikainen; Jussi Mikkelsson; Markus Perola; Antti Penttilä; Pekka J Karhunen
Platelet membrane collagen receptor glycoprotein VI polymorphism is associated with coronary thrombosis and fatal myocardial infarction in middle-aged men.
Atherosclerosis 2004;176(1):95-9.
2004: Tiina Paunio; Annamari Tuulio-Henriksson; Tero Hiekkalinna; Markus Perola; Teppo Varilo; Timo Partonen; Tyrone D Cannon; Jouko Lönnqvist; Leena Peltonen
Search for cognitive trait components of schizophrenia reveals a locus for verbal learning and memory on 4q and for visual working memory on 2q.
Human molecular genetics 2004;13(16):1693-702.
2004: Riikka Rontu; Terho Lehtimäki; Erkki Ilveskoski; Jussi Mikkelsson; Olli A Kajander; Sirkka Goebeler; Markus Perola; Antti Penttilä; Pekka J Karhunen
Association of paraoxonase-1 M55L genotype and alcohol consumption with coronary atherosclerosis: the Helsinki Sudden Death Study.
Pharmacogenetics 2004;14(8):479-85.
2004: Kim Pettersson-Fernholm; Carol Forsblom; Markus Perola; Johan Fagerudd; Per-Henrik Groop
Dopamine D3 receptor gene polymorphisms, blood pressure and nephropathy in type 1 diabetic patients.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2004;19(6):1432-6.
2003: Tarja A Kunnas; Jussi Mikkelsson; Erkki Ilveskoski; M M Tanner; Pekka Laippala; Antti Penttilä; Markus Perola; Seppo T Nikkari; Pekka J Karhunen
A functional variant of the iNOS gene flanking region is associated with LAD coronary artery disease: an autopsy study.
European journal of clinical investigation 2003;33(12):1032-7.
2003: Riikka Rontu; Pekka J Karhunen; Erkki Ilveskoski; Jussi Mikkelsson; Olli A Kajander; Markus Perola; Antti Penttilä; Anna-Maija Koivisto; Terho Lehtimäki
Smoking-dependent association between paraoxonase 1 M/L55 genotype and coronary atherosclerosis in males: an autopsy study.
Atherosclerosis 2003;171(1):31-7.
2003: Karri Silventoinen; Sampo Sammalisto; Markus Perola; Dorret I Boomsma; Belinda K Cornes; Chayna Davis; Leo Dunkel; Marlies De Lange; Jennifer R Harris; Jacob v B Hjelmborg; Michelle Luciano; Nicholas G Martin; Jakob Mortensen; Lorenza Nisticò; Nancy L Pedersen; Axel Skytthe; Tim D Spector; Maria Antonietta Stazi; Gonneke Willemsen; Jaakko Kaprio
Heritability of adult body height: a comparative study of twin cohorts in eight countries.
Twin research : the official journal of the International Society for Twin Studies 2003;6(5):399-408.
2003: Jenny Ekholm; Tuula Kieseppä; Tero Hiekkalinna; Timo Partonen; Tiina Paunio; Markus Perola; Jesper Ekelund; Jouko Lönnqvist; Petra Pekkarinen-Ijäs; Leena Peltonen
Evidence of susceptibility loci on 4q32 and 16p12 for bipolar disorder.
Human molecular genetics 2003;12(15):1907-15.
2003: Riikka Mäkelä; Pekka J Karhunen; Tarja A Kunnas; Erkki Ilveskoski; Olli A Kajander; Jussi Mikkelsson; Markus Perola; Antti Penttilä; Terho Lehtimäki
Myeloperoxidase gene variation as a determinant of atherosclerosis progression in the abdominal and thoracic aorta: an autopsy study.
Laboratory investigation; a journal of technical methods and pathology 2003;83(7):919-25.
2003: Heikki Mannila; M Koivisto; Markus Perola; Teppo Varilo; William Hennah; Jesper Ekelund; M Lukk; Leena Peltonen; Esko Ukkonen
Minimum description length block finder, a method to identify haplotype blocks and to compare the strength of block boundaries.
American journal of human genetics 2003;73(1):86-94.
2003: Kim Pettersson-Fernholm; Carol Forsblom; Markus Perola; Per-Henrik Groop
Polymorphisms in the nephrin gene and diabetic nephropathy in type 1 diabetic patients.
Kidney international 2003;63(4):1205-10.
2003: Kim Pettersson-Fernholm; Carol Forsblom; Barry I Hudson; Markus Perola; Peter J Grant; Per-Henrik Groop
The functional -374 T/A RAGE gene polymorphism is associated with proteinuria and cardiovascular disease in type 1 diabetic patients.
Diabetes 2003;52(3):891-4.
2003: Amir Snapir; Jussi Mikkelsson; Markus Perola; Antti Penttilä; Mika Scheinin; Pekka J Karhunen
Variation in the alpha2B-adrenoceptor gene as a risk factor for prehospital fatal myocardial infarction and sudden cardiac death.
Journal of the American College of Cardiology 2003;41(2):190-4.
2003: M Koivisto; Markus Perola; Teppo Varilo; William Hennah; Jesper Ekelund; M Lukk; Leena Peltonen; Esko Ukkonen; Heikki Mannila
An MDL method for finding haplotype blocks and for estimating the strength of haplotype block boundaries.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing 2003;():502-13.
2003: Teppo Varilo; Tiina Paunio; Alex Parker; Markus Perola; Joanne Meyer; Joseph D Terwilliger; Leena Peltonen
The interval of linkage disequilibrium (LD) detected with microsatellite and SNP markers in chromosomes of Finnish populations with different histories.
Human molecular genetics 2003;12(1):51-9.
2002: Jussi Mikkelsson; Markus Perola; Antti Penttilä; Pekka J Karhunen
Platelet collagen receptor GPIa (C807T/HPA-5) haplotype is not associated with an increased risk of fatal coronary events in middle-aged men.
Atherosclerosis 2002;165(1):111-8.
2002: Perttu J Pöllänen; Terho Lehtimäki; Erkki Ilveskoski; Jussi Mikkelsson; Olli A Kajander; Pekka Laippala; Markus Perola; Sirkka Goebeler; Antti Penttilä; Kari M Mattila; Kirsi Syrjäkoski; Timo Koivula; Seppo T Nikkari; Pekka J Karhunen
Coronary artery calcification is related to functional polymorphism of matrix metalloproteinase 3: the Helsinki Sudden Death Study.
Atherosclerosis 2002;164(2):329-35.
2002: Tarja A Kunnas; Erkki Ilveskoski; Tero Niskakangas; Pekka Laippala; Olli A Kajander; Jussi Mikkelsson; Sirkka Goebeler; Antti Penttilä; Markus Perola; Seppo T Nikkari; Pekka J Karhunen
Association of the endothelial nitric oxide synthase gene polymorphism with risk of coronary artery disease and myocardial infarction in middle-aged men.
Journal of molecular medicine (Berlin, Germany) 2002;80(9):605-9.
2002: Aino Soro; Päivi Pajukanta; Heidi E Lilja; Kati Ylitalo; Tero Hiekkalinna; Markus Perola; Rita M Cantor; Jorma S A Viikari; Marja-Riitta Taskinen; Leena Peltonen
Genome scans provide evidence for low-HDL-C loci on chromosomes 8q23, 16q24.1-24.2, and 20q13.11 in Finnish families.
American journal of human genetics 2002;70(5):1333-40.
2002: Terho Lehtimäki; Tarja A Kunnas; Kari M Mattila; Markus Perola; Antti Penttilä; Timo Koivula; Pekka J Karhunen
Coronary artery wall atherosclerosis in relation to the estrogen receptor 1 gene polymorphism: an autopsy study.
Journal of molecular medicine (Berlin, Germany) 2002;80(3):176-80.
2002: Natalia Berloff; Markus Perola; Kenneth Lange
Spline methods for the comparison of physical and genetic maps.
Journal of computational biology : a journal of computational molecular cell biology 2002;9(3):465-75.
2002: Jenny Ekholm; P Pekkarinen; Päivi Pajukanta; Tuula Kieseppä; Timo Partonen; Tiina Paunio; Teppo Varilo; Markus Perola; Jouko Lönnqvist; Leena Peltonen
Bipolar disorder susceptibility region on Xq24-q27.1 in Finnish families.
Molecular psychiatry 2002;7(5):453-9.
2001: Tomi Pastinen; Markus Perola; Jaakko Ignatius; C Sabatti; Päivi Tainola; M Levander; Ann-Christine Syvänen; Leena Peltonen
Dissecting a population genome for targeted screening of disease mutations.
Human molecular genetics 2001;10(26):2961-72.
2001: Olli A Kajander; Markku Kupari; Markus Perola; Jarkko Pajarinen; Vesa Savolainen; Antti Penttilä; Pekka J Karhunen
Testing genetic susceptibility loci for alcoholic heart muscle disease.
Alcoholism, clinical and experimental research 2001;25(10):1409-13.
2001: Perttu J Pöllänen; Pekka J Karhunen; Jussi Mikkelsson; Pekka Laippala; Markus Perola; Antti Penttilä; Kari M Mattila; Timo Koivula; Terho Lehtimäki
Coronary artery complicated lesion area is related to functional polymorphism of matrix metalloproteinase 9 gene: an autopsy study.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(9):1446-50.
2001: Jussi Mikkelsson; Markus Perola; Antti Penttilä; Pekka J Karhunen
Platelet glycoprotein Ibalpha HPA-2 Met/VNTR B haplotype as a genetic predictor of myocardial infarction and sudden cardiac death.
Circulation 2001;104(8):876-80.
2001: Markus Perola; Miina Ohman; Tero Hiekkalinna; J Leppävuori; Päivi Pajukanta; Maija Wessman; M Koskenvuo; Aarno Palotie; Kenneth Lange; Jaakko Kaprio; Leena Peltonen
Quantitative-trait-locus analysis of body-mass index and of stature, by combined analysis of genome scans of five Finnish study groups.
American journal of human genetics 2001;69(1):117-23.
2001: Harri A Järveläinen; A Orpana; Markus Perola; V T Savolainen; P J Karhunen; Kai O Lindros
Promoter polymorphism of the CD14 endotoxin receptor gene as a risk factor for alcoholic liver disease.
Hepatology (Baltimore, Md.) 2001;33(5):1148-53.
2001: Jussi Mikkelsson; Markus Perola; Antti Penttilä; Pascal J Goldschmidt-Clermont; P J Karhunen
The GPIIIa (beta3 integrin) PlA polymorphism in the early development of coronary atherosclerosis.
Atherosclerosis 2001;154(3):721-7.
2001: T Keso; Markus Perola; Pekka Laippala; Erkki Ilveskoski; Tarja A Kunnas; Jussi Mikkelsson; Antti Penttilä; Mikko Hurme; Pekka J Karhunen
Polymorphisms within the tumor necrosis factor locus and prevalence of coronary artery disease in middle-aged men.
Atherosclerosis 2001;154(3):691-7.
2000: Päivi Pajukanta; M Cargill; Laura Viitanen; Ilpo Nuotio; Anu Kareinen; Markus Perola; Joseph D Terwilliger; E Kempas; Mark J Daly; Heidi E Lilja; JD Rioux; T Brettin; Jorma S A Viikari; T Rönnemaa; Markku Laakso; Eric S Lander; Leena Peltonen
Two loci on chromosomes 2 and X for premature coronary heart disease identified in early- and late-settlement populations of Finland.
American journal of human genetics 2000;67(6):1481-93.
2000: Markus Perola; K Kainulainen; Päivi Pajukanta; Joseph D Terwilliger; Tero Hiekkalinna; Pekka Ellonen; Jaakko Kaprio; Markku Koskenvuo; Kimmo Kontula; Leena Peltonen
Genome-wide scan of predisposing loci for increased diastolic blood pressure in Finnish siblings.
Journal of hypertension 2000;18(11):1579-85.
2000: Jussi Mikkelsson; Markus Perola; Pekka Laippala; Antti Penttilä; Pekka J Karhunen
Glycoprotein IIIa Pl(A1/A2) polymorphism and sudden cardiac death.
Journal of the American College of Cardiology 2000;36(4):1317-23.
2000: Jussi Mikkelsson; Markus Perola; Ulla Wartiovaara; L Peltonen; Aarno Palotie; Antti Penttilä; Pekka J Karhunen
Plasminogen activator inhibitor-1 (PAI-1) 4G/5G polymorphism, coronary thrombosis, and myocardial infarction in middle-aged Finnish men who died suddenly.
Thrombosis and haemostasis 2000;84(1):78-82.
2000: Kimmo Kontula; Markus Perola; T Hiltunen; K Kainulainen; L Palotie
[Genes and hypertension].
Duodecim; lääketieteellinen aikakauskirja 2000;116(16):1751-8.
1999: Jussi Mikkelsson; Markus Perola; Leena Kauppila; Pekka Laippala; Vesa Savolainen; Jarkko Pajarinen; Antti Penttilä; Pekka J Karhunen
The GPIIIa Pl(A) polymorphism in the progression of abdominal aortic atherosclerosis.
Atherosclerosis 1999;147(1):55-60.
1999: Jussi Mikkelsson; Markus Perola; Pekka Laippala; Vesa Savolainen; Jarkko Pajarinen; Kaisa Lalu; Antti Penttilä; Pekka J Karhunen
Glycoprotein IIIa Pl(A) polymorphism associates with progression of coronary artery disease and with myocardial infarction in an autopsy series of middle-aged men who died suddenly.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(10):2573-8.
1999: Erkki Ilveskoski; Markus Perola; Terho Lehtimäki; Pekka Laippala; Vesa Savolainen; Jarkko Pajarinen; Antti Penttilä; Kaisa Lalu; A Männikkö; K K Liesto; Timo Koivula; Pekka J Karhunen
Age-dependent association of apolipoprotein E genotype with coronary and aortic atherosclerosis in middle-aged men: an autopsy study.
Circulation 1999;100(6):608-13.
1999: Päivi Pajukanta; Joseph D Terwilliger; Markus Perola; Tero Hiekkalinna; Ilpo Nuotio; Pekka Ellonen; Maija Parkkonen; Jaana Hartiala; Kati Ylitalo; Jussi Pihlajamäki; Kimmo Porkka; Markku Laakso; Jorma Viikari; Christian Ehnholm; Marja-Riitta Taskinen; Leena Peltonen
Genomewide scan for familial combined hyperlipidemia genes in finnish families, suggesting multiple susceptibility loci influencing triglyceride, cholesterol, and apolipoprotein B levels.
American journal of human genetics 1999;64(5):1453-63.
1999: K Kainulainen; Markus Perola; Joseph D Terwilliger; Jaakko Kaprio; Markku Koskenvuo; Ann-Christine Syvänen; E Vartiainen; Leena Peltonen; Kimmo Kontula
Evidence for involvement of the type 1 angiotensin II receptor locus in essential hypertension.
Hypertension 1999;33(3):844-9.
1999: Ulla Wartiovaara; Markus Perola; H Mikkola; K Tötterman; Vesa Savolainen; Antti Penttilä; P J Grant; Matti J Tikkanen; Erkki Vartiainen; Pekka J Karhunen; Leena Peltonen; Aarno Palotie
Association of FXIII Val34Leu with decreased risk of myocardial infarction in Finnish males.
Atherosclerosis 1999;142(2):295-300.
1999: Olli A Kajander; Tarja A Kunnas; Markus Perola; Saara Lehtinen; Pekka J Karhunen; Howard T Jacobs
Long-extension PCR to detect deleted mitochondrial DNA molecules is compromized by technical artefacts.
Biochemical and biophysical research communications 1999;254(2):507-14.
1998: Tomi Pastinen; Markus Perola; P Niini; Joseph D Terwilliger; Veikko Salomaa; E Vartiainen; Leena Peltonen; Ann-Christine Syvänen
Array-based multiplex analysis of candidate genes reveals two independent and additive genetic risk factors for myocardial infarction in the Finnish population.
Human molecular genetics 1998;7(9):1453-62.
1998: Tomi Pastinen; Markus Perola
[DNA chips--a new diagnostic revolution?].
Duodecim; lääketieteellinen aikakauskirja 1998;114(9):829, 831.
1997: Kimmo Porkka; Ilpo Nuotio; Päivi Pajukanta; Christian Ehnholm; L Suurinkeroinen; Mikko Syvänne; Terho Lehtimäki; Anne-Tiina Lahdenkari; Sanni Lahdenperä; Kati Ylitalo; Marjatta Antikainen; Markus Perola; Olli T Raitakari; Petri T Kovanen; Jorma S A Viikari; Leena Peltonen; Marja-Riitta Taskinen
Phenotype expression in familial combined hyperlipidemia.
Atherosclerosis 1997;133(2):245-53.
1997: Päivi Pajukanta; Kimmo Porkka; Marjatta Antikainen; Marja-Riitta Taskinen; Markus Perola; S Murtomäki-Repo; Sonja Jaari; Ilpo Nuotio; L Suurinkeroinen; Anne-Tiina Lahdenkari; Ann-Christine Syvänen; Jorma S A Viikari; Christian Ehnholm; Leena Peltonen
No evidence of linkage between familial combined hyperlipidemia and genes encoding lipolytic enzymes in Finnish families.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(5):841-50.
1997: Vesa Savolainen; Jarkko Pajarinen; Markus Perola; Antti Penttilä; Pekka J Karhunen
Polymorphism in the cytochrome P450 2E1 gene and the risk of alcoholic liver disease.
Journal of hepatology 1997;26(1):55-61.
1996: Vesa Savolainen; J Pjarinen; Markus Perola; Antti Penttilä; Pekka J Karhunen
Glutathione-S-transferase GST M1 "null" genotype and the risk of alcoholic liver disease.
Alcoholism, clinical and experimental research 1996;20(8):1340-5.
1996: Jarkko Pajarinen; Vesa Savolainen; Markus Perola; Antti Penttilä; Pekka J Karhunen
Polymorphism in the cytochrome P450 2E1 gene and alcohol-induced disorders of human spermatogenesis.
International journal of andrology 1996;19(5):314-22.
1996: Jarkko Pajarinen; Vesa Savolainen; Markus Perola; Antti Penttilä; Pekka J Karhunen
Glutathione S-transferase-M1 'null' genotype and alcohol-induced disorders of human spermatogenesis.
International journal of andrology 1996;19(3):155-63.
1995: Vesa Savolainen; Markus Perola; K Lalu; Antti Penttilä; I Virtanen; Pekka J Karhunen
Early perivenular fibrogenesis--precirrhotic lesions among moderate alcohol consumers and chronic alcoholics.
Journal of hepatology 1995;23(5):524-31.
1995: Markus Perola; Antti Sajantila; Cinzia Sarti; Jari H Stengård; M Tamminen; P Puska; J Huttunen; J Tuomilehto; L Peltonen
Angiotensin-converting enzyme genotypes in the high- and low-risk area for coronary heart disease in Finland.
Genetic epidemiology 1995;12(4):391-9.
1994: Markku Kupari; Markus Perola; Petri Koskinen; J Virolainen; Pekka J Karhunen
Left ventricular size, mass, and function in relation to angiotensin-converting enzyme gene polymorphism in humans.
The American journal of physiology 1994;267(3 Pt 2):H1107-11.
1994: Markus Perola; Erkki Vuori; Antti Penttilä
Abuse of alcohol in sudden out-of-hospital deaths in Finland.
Alcoholism, clinical and experimental research 1994;18(2):255-60.