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Eduardo Perozo

Research Profile

Physiology

Ion Channel Gating

Chemicals & Drugs

Concepts & Ideas

Procedures

Living Beings

Genes & Molecular Sequences

Amino Acid Sequences

Anatomy

Lipid Bilayers

Co-author Network

Publications

TOP 3
Ernesto Vargas; Vladimir Yarov-Yarovoy; Klaus Schulten; Mounir Tarek; Francisco Bezanilla; William A Catterall; Fatemeh Khalili-Araghi; Michael L Klein; Erik Lindahl; Eduardo Perozo; Benoît Roux
An emerging consensus on voltage-dependent gating from computational modeling and molecular dynamics simulations.
Qufei Li; D Marien Cortes; Vishwanath Jogini; Sherry Wanderling; Eduardo Perozo
Expression, purification, and reconstitution of the voltage-sensing domain from Ci-VSP.
Olivier Dalmas; Raymond E Hulse; H Clark Hyde; Eduardo Perozo
Symmetry-constrained analysis of pulsed double electron-electron resonance (DEER) spectroscopy reveals the dynamic nature of the KcsA activation gate.

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All Publications

2012: Ernesto Vargas; Vladimir Yarov-Yarovoy; Klaus Schulten; Mounir Tarek; Francisco Bezanilla; William A Catterall; Fatemeh Khalili-Araghi; Michael L Klein; Erik Lindahl; Eduardo Perozo; Benoît Roux
An emerging consensus on voltage-dependent gating from computational modeling and molecular dynamics simulations.
The Journal of general physiology 2012;140(6):587-94.
2012: Qufei Li; D Marien Cortes; Vishwanath Jogini; Sherry Wanderling; Eduardo Perozo
Expression, purification, and reconstitution of the voltage-sensing domain from Ci-VSP.
Biochemistry 2012;51(41):8132-42.
2012: Olivier Dalmas; Raymond E Hulse; H Clark Hyde; Eduardo Perozo
Symmetry-constrained analysis of pulsed double electron-electron resonance (DEER) spectroscopy reveals the dynamic nature of the KcsA activation gate.
Journal of the American Chemical Society 2012;134(39):16360-9.
2012: H Raghuraman; Benoît Roux; Julio F Cordero-Morales; Vishwanath Jogini; Astrid Kollewe; Albert C Pan; Eduardo Perozo
Mechanism of Cd2+ coordination during slow inactivation in potassium channels.
Structure (London, England : 1993) 2012;20(8):1332-42.
2011: Albert C Pan; Eduardo Perozo; Luis G Cuello; Benoît Roux
Thermodynamic coupling between activation and inactivation gating in potassium channels revealed by free energy molecular dynamics simulations.
The Journal of general physiology 2011;138(6):571-80.
2011: Tania Ferrer; Eckhard Ficker; David Medovoy; Eduardo Perozo; Marcelo Arias; Julio F Cordero-Morales; Martin Tristani-Firouzi
Molecular coupling in the human ether-a-go-go-related gene-1 (hERG1) K+ channel inactivation pathway.
The Journal of biological chemistry 2011;286(45):39091-9.
2011: Serdar Uysal; D Marien Cortes; Luis G Cuello; Shohei Koide; Anthony A Kossiakoff; Eduardo Perozo
Mechanism of activation gating in the full-length KcsA K+ channel.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(29):11896-9.
2011: Julio F Cordero-Morales; Vishwanath Jogini; Sudha Chakrapani; Eduardo Perozo
A multipoint hydrogen-bond network underlying KcsA C-type inactivation.
Biophysical journal 2011;100(10):2387-93.
2011: Sudha Chakrapani; Julio F Cordero-Morales; Vishwanath Jogini; Albert C Pan; D Marien Cortes; Benoît Roux; Eduardo Perozo
On the structural basis of modal gating behavior in K(+) channels.
Nature structural & molecular biology 2011;18(1):67-74.
2010: Raymond E Hulse; Qufei Li; Eduardo Perozo
Up a hydrophobic creek with a short paddle.
Cell 2010;142(4):515-6.
2010: Olivier Dalmas; Luis G Cuello; Vishwanath Jogini; D Marien Cortes; Benoît Roux; Eduardo Perozo
Structural dynamics of the magnesium-bound conformation of CorA in a lipid bilayer.
Structure (London, England : 1993) 2010;18(7):868-78.
2010: Luis G Cuello; Vishwanath Jogini; D Marien Cortes; Albert C Pan; Dominique G Gagnon; Olivier Dalmas; Julio F Cordero-Morales; Sudha Chakrapani; Benoît Roux; Eduardo Perozo
Structural basis for the coupling between activation and inactivation gates in K(+) channels.
Nature 2010;466(7303):272-5.
2010: Luis G Cuello; Vishwanath Jogini; D Marien Cortes; Eduardo Perozo
Structural mechanism of C-type inactivation in K(+) channels.
Nature 2010;466(7303):203-8.
2010: Sudha Chakrapani; Pornthep Sompornpisut; Pathumwadee Intharathep; Benoît Roux; Eduardo Perozo
The activated state of a sodium channel voltage sensor in a membrane environment.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(12):5435-40.
2010: Luis G Cuello; Vishwanath Jogini; D Marien Cortes; Amornrat Sompornpisut; Michael D Purdy; Michael C Wiener; Eduardo Perozo
Design and characterization of a constitutively open KcsA.
FEBS letters 2010;584(6):1133-8.
2010: Luis G Cuello; D Marien Cortes; Vishwanath Jogini; Amornrat Sompornpisut; Eduardo Perozo
A molecular mechanism for proton-dependent gating in KcsA.
FEBS letters 2010;584(6):1126-32.
2009: Zoltan Takacs; Megan Toups; Astrid Kollewe; Erik Johnson; Luis G Cuello; Gregory Driessens; Matthew Biancalana; Akiko Koide; Cristiano G Ponte; Eduardo Perozo; Thomas F Gajewski; Guilherme Suarez-Kurtz; Shohei Koide; Steve A N Goldstein
A designer ligand specific for Kv1.3 channels from a scorpion neurotoxin-based library.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(52):22211-6.
2009: Valeria Vásquez; Eduardo Perozo
Structural biology: A channel with a twist.
Nature 2009;461(7260):47-9.
2009: Serdar Uysal; Valeria Vásquez; Valentina Tereshko; Kaori Esaki; Frederic A Fellouse; Sachdev S Sidhu; Shohei Koide; Eduardo Perozo; Anthony A Kossiakoff
Crystal structure of full-length KcsA in its closed conformation.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(16):6644-9.
2009: Vladimir Yu Torbeev; H Raghuraman; Kalyaneswar Mandal; Sanjib Senapati; Eduardo Perozo; Stephen B H Kent
Dynamics of "flap" structures in three HIV-1 protease/inhibitor complexes probed by total chemical synthesis and pulse-EPR spectroscopy.
Journal of the American Chemical Society 2009;131(3):884-5.
2009: Birke A Goetz; Eduardo Perozo; Kaspar P Locher
Distinct gate conformations of the ABC transporter BtuCD revealed by electron spin resonance spectroscopy and chemical cross-linking.
FEBS letters 2009;583(2):266-70.
2008: Pornthep Sompornpisut; Benoît Roux; Eduardo Perozo
Structural refinement of membrane proteins by restrained molecular dynamics and solvent accessibility data.
Biophysical journal 2008;95(11):5349-61.
2008: Valeria Vásquez; Marcos Sotomayor; Julio Cordero-Morales; Klaus Schulten; Eduardo Perozo
A structural mechanism for MscS gating in lipid bilayers.
Science (New York, N.Y.) 2008;321(5893):1210-4.
2008: Valeria Vásquez; Marcos Sotomayor; D Marien Cortes; Benoît Roux; Klaus Schulten; Eduardo Perozo
Three-dimensional architecture of membrane-embedded MscS in the closed conformation.
Journal of molecular biology 2008;378(1):55-70.
2008: Sudha Chakrapani; Luis G Cuello; D Marien Cortes; Eduardo Perozo
Structural dynamics of an isolated voltage-sensor domain in a lipid bilayer.
Structure (London, England : 1993) 2008;16(3):398-409.
2007: Sudha Chakrapani; Julio F Cordero-Morales; Eduardo Perozo
A quantitative description of KcsA gating II: single-channel currents.
The Journal of general physiology 2007;130(5):479-96.
2007: Sudha Chakrapani; Julio F Cordero-Morales; Eduardo Perozo
A quantitative description of KcsA gating I: macroscopic currents.
The Journal of general physiology 2007;130(5):465-78.
2007: Julio F Cordero-Morales; Vishwanath Jogini; Anthony Lewis; Valeria Vásquez; D Marien Cortes; Benoît Roux; Eduardo Perozo
Molecular driving forces determining potassium channel slow inactivation.
Nature structural & molecular biology 2007;14(11):1062-9.
2007: Rikki N Hvorup; Birke A Goetz; Martina Niederer; Kaspar Hollenstein; Eduardo Perozo; Kaspar P Locher
Asymmetry in the structure of the ABC transporter-binding protein complex BtuCD-BtuF.
Science (New York, N.Y.) 2007;317(5843):1387-90.
2007: Valeria Vásquez; D Marien Cortes; Hiro Furukawa; Eduardo Perozo
An optimized purification and reconstitution method for the MscS channel: strategies for spectroscopical analysis.
Biochemistry 2007;46(23):6766-73.
2007: Sudha Chakrapani; Eduardo Perozo
How to gate an ion channel: lessons from MthK.
Nature structural & molecular biology 2007;14(3):180-2.
2007: Marcos Sotomayor; Valeria Vásquez; Eduardo Perozo; Klaus Schulten
Ion conduction through MscS as determined by electrophysiology and simulation.
Biophysical journal 2007;92(3):886-902.
2006: Rikard Blunck; Julio F Cordero-Morales; Luis G Cuello; Eduardo Perozo; Francisco Bezanilla
Detection of the opening of the bundle crossing in KcsA with fluorescence lifetime spectroscopy reveals the existence of two gates for ion conduction.
The Journal of general physiology 2006;128(5):569-81.
2006: Julio F Cordero-Morales; Luis G Cuello; Yanxiang Zhao; Vishwanath Jogini; D Marien Cortes; Benoît Roux; Eduardo Perozo
Molecular determinants of gating at the potassium-channel selectivity filter.
Nature structural & molecular biology 2006;13(4):311-8.
2006: Julio F Cordero-Morales; Luis G Cuello; Eduardo Perozo
Voltage-dependent gating at the KcsA selectivity filter.
Nature structural & molecular biology 2006;13(4):319-22.
2006: Eduardo Perozo
Gating prokaryotic mechanosensitive channels.
Nature reviews. Molecular cell biology 2006;7(2):109-19.
2005: Ken Sale; Likai Song; Yi-Shiuan Liu; Eduardo Perozo; Piotr G Fajer
Explicit treatment of spin labels in modeling of distance constraints from dipolar EPR and DEER.
Journal of the American Chemical Society 2005;127(26):9334-5.
2005: Celeste Ptak; Luis G Cuello; Eduardo Perozo
Electrostatic interaction of a K+ channel RCK domain with charged membrane surfaces.
Biochemistry 2005;44(1):62-71.
2004: Luis G Cuello; D Marien Cortes; Eduardo Perozo
Molecular architecture of the KvAP voltage-dependent K+ channel in a lipid bilayer.
Science (New York, N.Y.) 2004;306(5695):491-5.
2003: Eduardo Perozo; Douglas C Rees
Structure and mechanism in prokaryotic mechanosensitive channels.
Current opinion in structural biology 2003;13(4):432-42.
2003: Francisco Bezanilla; Eduardo Perozo
The voltage sensor and the gate in ion channels.
Advances in protein chemistry 2003;63():211-41.
2002: Francisco Bezanilla; Eduardo Perozo
Structural biology. Force and voltage sensors in one structure.
Science (New York, N.Y.) 2002;298(5598):1562-3.
2002: Jing Li; Qiang Xu; D Marien Cortes; Eduardo Perozo; Aaron Laskey; Arthur Karlin
Reactions of cysteines substituted in the amphipathic N-terminal tail of a bacterial potassium channel with hydrophilic and hydrophobic maleimides.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(18):11605-10.
2002: Eduardo Perozo; Anna Kloda; D Marien Cortes; Boris Martinac
Physical principles underlying the transduction of bilayer deformation forces during mechanosensitive channel gating.
Nature structural biology 2002;9(9):696-703.
2002: Eduardo Perozo; D Marien Cortes; Pornthep Sompornpisut; Anna Kloda; Boris Martinac
Open channel structure of MscL and the gating mechanism of mechanosensitive channels.
Nature 2002;418(6901):942-8.
2002: Eduardo Perozo
New structural perspectives on K(+) channel gating.
Structure (London, England : 1993) 2002;10(8):1027-9.
2002: Eduardo Perozo; Luis G Cuello; D Marien Cortes; YS Liu; Pornthep Sompornpisut
EPR approaches to ion channel structure and function.
Novartis Foundation symposium 2002;245():146-58; discussion 158-64, 165-8.
2001: Pornthep Sompornpisut; YS Liu; Eduardo Perozo
Calculation of rigid-body conformational changes using restraint-driven Cartesian transformations.
Biophysical journal 2001;81(5):2530-46.
2001: YS Liu; Pornthep Sompornpisut; Eduardo Perozo
Structure of the KcsA channel intracellular gate in the open state.
Nature structural biology 2001;8(10):883-7.
2001: Eduardo Perozo; Anna Kloda; D Marien Cortes; Boris Martinac
Site-directed spin-labeling analysis of reconstituted Mscl in the closed state.
The Journal of general physiology 2001;118(2):193-206.
2001: D Marien Cortes; Luis G Cuello; Eduardo Perozo
Molecular architecture of full-length KcsA: role of cytoplasmic domains in ion permeation and activation gating.
The Journal of general physiology 2001;117(2):165-80.
2000: Eduardo Perozo
Structure and packing orientation of transmembrane segments in voltage-dependent channels. Lessons from perturbation analysis.
The Journal of general physiology 2000;115(1):29-32.
1999: Eduardo Perozo; D Marien Cortes; Luis G Cuello
Structural rearrangements underlying K+-channel activation gating.
Science (New York, N.Y.) 1999;285(5424):73-8.
1998: Eduardo Perozo
Shedding light on voltage-dependent gating.
The Journal of general physiology 1998;112(4):373-6.
1998: Eduardo Perozo; D Marien Cortes; Luis G Cuello
Three-dimensional architecture and gating mechanism of a K+ channel studied by EPR spectroscopy.
Nature structural biology 1998;5(6):459-69.
1998: Luis G Cuello; J G Romero; D Marien Cortes; Eduardo Perozo
pH-dependent gating in the Streptomyces lividans K+ channel.
Biochemistry 1998;37(10):3229-36.
1998: SA Tatulian; D Marien Cortes; Eduardo Perozo
Structural dynamics of the Streptomyces lividans K+ channel (SKC1): secondary structure characterization from FTIR spectroscopy.
FEBS letters 1998;423(2):205-12.
1997: D Marien Cortes; Eduardo Perozo
Structural dynamics of the Streptomyces lividans K+ channel (SKC1): oligomeric stoichiometry and stability.
Biochemistry 1997;36(33):10343-52.