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Remo Perozzo

Research Profile

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Simone Pieretti; Federica Prati; Leonardo Scapozza; Barbara M Bakker; Christian Bergamini; Maria Laura Bolognesi; Reto Brun; Giovanni Capranico; Romana Fato; Jurgen Haanstra; Giorgio Lenaz; Muriel Mazet; Paul A M Michels; Remo Perozzo; Andrea Cavalli
Naphthoquinone derivatives exert their antitrypanosomal activity via a multi-target mechanism.
Yogeshvar N Kalia; Remo Perozzo; Leonardo Scapozza
The pharmaceutical biochemistry group: where pharmaceutical chemistry meets biology and drug delivery.
Vincent Jaquet; Karl-Heinz Krause; Kevin G Leidal; Julien Marcoux; Sally McCormick; William M Nauseef; Remo Perozzo; Olivier Plastre; Leonardo Scapozza; Yvonne Westermaier; Becky Diebold; Franck Fieschi; Laetitia Fioraso-Cartier; Eric Forest; Karen Bedard
NADPH oxidase (NOX) isoforms are inhibited by celastrol with a dual mode of action.

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All Publications

2013: Simone Pieretti; Federica Prati; Leonardo Scapozza; Barbara M Bakker; Christian Bergamini; Maria Laura Bolognesi; Reto Brun; Giovanni Capranico; Romana Fato; Jurgen Haanstra; Giorgio Lenaz; Muriel Mazet; Paul A M Michels; Remo Perozzo; Andrea Cavalli
Naphthoquinone derivatives exert their antitrypanosomal activity via a multi-target mechanism.
PLoS neglected tropical diseases 2013;7(1):e2012.
2012: Yogeshvar N Kalia; Remo Perozzo; Leonardo Scapozza
The pharmaceutical biochemistry group: where pharmaceutical chemistry meets biology and drug delivery.
Chimia 2012;66(5):313-9.
2011: Vincent Jaquet; Karl-Heinz Krause; Kevin G Leidal; Julien Marcoux; Sally McCormick; William M Nauseef; Remo Perozzo; Olivier Plastre; Leonardo Scapozza; Yvonne Westermaier; Becky Diebold; Franck Fieschi; Laetitia Fioraso-Cartier; Eric Forest; Karen Bedard
NADPH oxidase (NOX) isoforms are inhibited by celastrol with a dual mode of action.
British journal of pharmacology 2011;164(2b):507-20.
2011: Sabine Kuettel; Jason Greenwald; Dirk Kostrewa; Shaheen Ahmed; Leonardo Scapozza; Remo Perozzo
Crystal structures of T. b. rhodesiense adenosine kinase complexed with inhibitor and activator: implications for catalysis and hyperactivation.
PLoS neglected tropical diseases 2011;5(5):e1164.
2011: Miljen Martić; Silvana Raic-Malic; Tatjana Gazivoda Kraljević; Svjetlana Krištafor; Lucile Pernot; Yvonne Westermaier; Remo Perozzo; Leonardo Scapozza; Simon M Ametamey
Synthesis, crystal structure, and in vitro biological evaluation of C-6 pyrimidine derivatives: new lead structures for monitoring gene expression in vivo.
Nucleosides, nucleotides & nucleic acids 2011;30(4):293-315.
2010: Deniz Tasdemir; David Sanabria; Ina L Lauinger; Alice Tarun; Rob Herman; Remo Perozzo; Mire Zloh; Stefan Kappe; Reto Brun; Néstor M Carballeira
2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections.
Bioorganic & medicinal chemistry 2010;18(21):7475-85.
2010: Francesco Colizzi; Remo Perozzo; Leonardo Scapozza; Maurizio Recanatini; Andrea Cavalli
Single-molecule pulling simulations can discern active from inactive enzyme inhibitors.
Journal of the American Chemical Society 2010;132(21):7361-71.
2009: Sabine Kuettel; Marc Mosimann; Pascal Mäser; Marcel Kaiser; Reto Brun; Leonardo Scapozza; Remo Perozzo
Adenosine Kinase of T. b. Rhodesiense identified as the putative target of 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine using chemical proteomics.
PLoS neglected tropical diseases 2009;3(8):e506.
2008: Anastasia Karioti; Helen Skaltsa; Xujie Zhang; Peter J Tonge; Remo Perozzo; Marcel Kaiser; Scott Franzblau; Deniz Tasdemir
Inhibiting enoyl-ACP reductase (FabI) across pathogenic microorganisms by linear sesquiterpene lactones from Anthemis auriculata.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2008;15(12):1125-9.
2008: Maria Laura Bolognesi; Federica Lizzi; Remo Perozzo; Reto Brun; Andrea Cavalli
Synthesis of a small library of 2-phenoxy-1,4-naphthoquinone and 2-phenoxy-1,4-anthraquinone derivatives bearing anti-trypanosomal and anti-leishmanial activity.
Bioorganic & medicinal chemistry letters 2008;18(7):2272-6.
2008: Sébastien Conus; Remo Perozzo; Thomas Reinheckel; Christoph Peters; Leonardo Scapozza; Shida Yousefi; Hans-Uwe Simon
Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation.
The Journal of experimental medicine 2008;205(3):685-98.
2007: Sabine Kuettel; Alfonso Zambon; Marcel Kaiser; Reto Brun; Leonardo Scapozza; Remo Perozzo
Synthesis and evaluation of antiparasitic activities of new 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine derivatives.
Journal of medicinal chemistry 2007;50(23):5833-9.
2007: Deniz Tasdemir; Bülent Topaloglu; Remo Perozzo; Reto Brun; Rosann O'Neill; Néstor M Carballeira; Xujie Zhang; Peter J Tonge; Anthony Linden; Peter Rüedi
Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tuberculosis and Escherichia coli.
Bioorganic & medicinal chemistry 2007;15(21):6834-45.
2007: Anastasia Karioti; Helen Skaltsa; Anthony Linden; Remo Perozzo; Reto Brun; Deniz Tasdemir
Anthecularin: a novel sesquiterpene lactone from Anthemis auriculata with antiprotozoal activity.
The Journal of organic chemistry 2007;72(21):8103-6.
2006: Shida Yousefi; Remo Perozzo; Inès Schmid; Andrew Ziemiecki; Thomas Schaffner; Leonardo Scapozza; Thomas Brunner; Hans-Uwe Simon
Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis.
Nature cell biology 2006;8(10):1124-32.
2006: Deniz Tasdemir; Gabriela Lack; Reto Brun; Peter Rüedi; Leonardo Scapozza; Remo Perozzo
Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids.
Journal of medicinal chemistry 2006;49(11):3345-53.
2006: Ilkay Orhan; Bilge Sener; T Atici; Reto Brun; Remo Perozzo; Deniz Tasdemir
Turkish freshwater and marine macrophyte extracts show in vitro antiprotozoal activity and inhibit FabI, a key enzyme of Plasmodium falciparum fatty acid biosynthesis.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2006;13(6):388-93.
2006: Markus S Birringer; Remo Perozzo; Elvan Kut; Corinne Stillhart; Wanda Surber; Leonardo Scapozza; Gerd Folkers
High-level expression and purification of human thymidine kinase 1: quaternary structure, stability, and kinetics.
Protein expression and purification 2006;47(2):506-15.
2006: Gabriela Lack; Eleonora Homberger-Zizzari; Gerd Folkers; Leonardo Scapozza; Remo Perozzo
Recombinant expression and biochemical characterization of the unique elongating beta-ketoacyl-acyl carrier protein synthase involved in fatty acid biosynthesis of Plasmodium falciparum using natural and artificial substrates.
The Journal of biological chemistry 2006;281(14):9538-46.
2005: Dirk Kostrewa; Fritz K Winkler; Gerd Folkers; Leonardo Scapozza; Remo Perozzo
The crystal structure of PfFabZ, the unique beta-hydroxyacyl-ACP dehydratase involved in fatty acid biosynthesis of Plasmodium falciparum.
Protein science : a publication of the Protein Society 2005;14(6):1570-80.
2005: Deniz Tasdemir; Reto Brun; Remo Perozzo; Ali A Dönmez
Evaluation of antiprotozoal and plasmodial enoyl-ACP reductase inhibition potential of turkish medicinal plants.
Phytotherapy research : PTR 2005;19(2):162-6.
2005: Deniz Tasdemir; Nadide Deniz Güner; Remo Perozzo; Reto Brun; Ali A Dönmez; Ihsan Calis; Peter Rüedi
Anti-protozoal and plasmodial FabI enzyme inhibiting metabolites of Scrophularia lepidota roots.
Phytochemistry 2005;66(3):355-62.
2004: Hasan Kirmizibekmez; Ihsan Calis; Remo Perozzo; Reto Brun; Ali A Dönmez; Anthony Linden; Peter Rüedi; Deniz Tasdemir
Inhibiting activities of the secondary metabolites of Phlomis brunneogaleata against parasitic protozoa and plasmodial enoyl-ACP Reductase, a crucial enzyme in fatty acid biosynthesis.
Planta medica 2004;70(8):711-7.
2004: Remo Perozzo; Gerd Folkers; Leonardo Scapozza
Thermodynamics of protein-ligand interactions: history, presence, and future aspects.
Journal of receptor and signal transduction research 2004;24(1-2):1-52.
2003: Mack R Kuo; HECTOR MORBIDONI; David Alland; Scott F Sneddon; Brian B Gourlie; Mark M Staveski; Marina Leonard; Jill S Gregory; Andrew D Janjigian; Christopher Yee; James M Musser; Barry Kreiswirth; Hiroyuki Iwamoto; Remo Perozzo; William R. Jacobs Jr.; James C Sacchettini; Fidock David
Targeting tuberculosis and malaria through inhibition of Enoyl reductase: compound activity and structural data.
The Journal of biological chemistry 2003;278(23):20851-9.
2002: Remo Perozzo; Mack Kuo; Amar Bir Singh Sidhu; Jacob T Valiyaveettil; Robert Bittman; William R. Jacobs Jr.; Fidock David; James C Sacchettini
Structural elucidation of the specificity of the antibacterial agent triclosan for malarial enoyl acyl carrier protein reductase.
The Journal of biological chemistry 2002;277(15):13106-14.
2000: Joachim Vogt; Remo Perozzo; Alexander Pautsch; Andrea E Prota; Pierre Schelling; BD Pilger; Gerd Folkers; Leonardo Scapozza; Georg E Schulz
Nucleoside binding site of herpes simplex type 1 thymidine kinase analyzed by X-ray crystallography.
Proteins 2000;41(4):545-53.
2000: Andrea E Prota; Joachim Vogt; BD Pilger; Remo Perozzo; C Wurth; Victor E Marquez; Pamela Russ; Georg E Schulz; Gerd Folkers; Leonardo Scapozza
Kinetics and crystal structure of the wild-type and the engineered Y101F mutant of Herpes simplex virus type 1 thymidine kinase interacting with (North)-methanocarba-thymidine.
Biochemistry 2000;39(31):9597-603.
2000: Remo Perozzo; Ilian Jelesarov; Hans Rudolf Bosshard; Gerd Folkers; Leonardo Scapozza
Compulsory order of substrate binding to herpes simplex virus type 1 thymidine kinase. A calorimetric study.
The Journal of biological chemistry 2000;275(21):16139-45.
1999: BD Pilger; Remo Perozzo; Frank Alber; C Wurth; Gerd Folkers; Leonardo Scapozza
Substrate diversity of herpes simplex virus thymidine kinase. Impact Of the kinematics of the enzyme.
The Journal of biological chemistry 1999;274(45):31967-73.
1999: Sibylle Kaspar; Remo Perozzo; Stefan Reinelt; Margareta Meyer; K Pfister; Leonardo Scapozza; Michael Bott
The periplasmic domain of the histidine autokinase CitA functions as a highly specific citrate receptor.
Molecular microbiology 1999;33(4):858-72.