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Sarah Perrett

Research Profile

Chemicals & Drugs

Concepts & Ideas

Physiology

Living Beings

Saccharomyces cerevisiae

Disorders

Protein Denaturation

Phenomena

Genes & Molecular Sequences

Amino Acid Sequences

Co-author Network

Publications

TOP 3
Motao Zhu; Sarah Perrett; Guangjun Nie
Understanding the particokinetics of engineered nanomaterials for safe and effective therapeutic applications.
Li-Qiong Xu; Hong Zhang; Mark E Welland; Si Wu; Alexander K Buell; Li-Jun Chen; Samuel I A Cohen; Sarah A Cusack; Christopher M Dobson; Wan-Hui Hu; Laura S Itzhaki; Gary W Jones; Tuomas P J Knowles; Sarah Perrett
Influence of specific HSP70 domains on fibril formation of the yeast prion protein Ure2.
Elizabeth B Sawyer; Dennis Claessen; Sally L Gras; Sarah Perrett
Exploiting amyloid: how and why bacteria use cross-β fibrils.

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All Publications

2013: Motao Zhu; Sarah Perrett; Guangjun Nie
Understanding the particokinetics of engineered nanomaterials for safe and effective therapeutic applications.
Small (Weinheim an der Bergstrasse, Germany) 2013;9(9-10):1619-34.
2013: Li-Qiong Xu; Hong Zhang; Mark E Welland; Si Wu; Alexander K Buell; Li-Jun Chen; Samuel I A Cohen; Sarah A Cusack; Christopher M Dobson; Wan-Hui Hu; Laura S Itzhaki; Gary W Jones; Tuomas P J Knowles; Sarah Perrett
Influence of specific HSP70 domains on fibril formation of the yeast prion protein Ure2.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2013;368(1617):20110410.
2012: Elizabeth B Sawyer; Dennis Claessen; Sally L Gras; Sarah Perrett
Exploiting amyloid: how and why bacteria use cross-β fibrils.
Biochemical Society transactions 2012;40(4):728-34.
2012: Weibin Gong; Jinjin Mo; Sarah Perrett; Jinfeng Wang; Tao Zhou; Yingang Feng
Structural insight into recognition of methylated histone tails by retinoblastoma-binding protein 1.
The Journal of biological chemistry 2012;287(11):8531-40.
2011: Li-Jun Chen; Elizabeth B Sawyer; Sarah Perrett
The yeast prion protein Ure2: insights into the mechanism of amyloid formation.
Biochemical Society transactions 2011;39(5):1359-64.
2011: Yi-Qian Wang; Marie Bongiovanni; Sally L Gras; Sarah Perrett
The fibrils of Ure2p homologs from Saccharomyces cerevisiae and Saccharoymyces paradoxus have similar cross-β structure in both dried and hydrated forms.
Journal of structural biology 2011;174(3):505-11.
2011: Yi-Qian Wang; Alexander K Buell; Xin-Yu Wang; Mark E Welland; Christopher M Dobson; Tuomas P J Knowles; Sarah Perrett
Relationship between prion propensity and the rates of individual molecular steps of fibril assembly.
The Journal of biological chemistry 2011;286(14):12101-7.
2011: Hong Zhang; Li-Qiong Xu; Sarah Perrett
Studying the effects of chaperones on amyloid fibril formation.
Methods (San Diego, Calif.) 2011;53(3):285-94.
2011: Yong Yu; Hai-Yan Wang; Ming Bai; Sarah Perrett
Flexibility of the Ure2 prion domain is important for amyloid fibril formation.
The Biochemical journal 2011;434(1):143-51.
2010: Chen Zhang; Antony P Jackson; Zai-Rong Zhang; Yan Han; Shun Yu; Rong-Qiao He; Sarah Perrett
Amyloid-like aggregates of the yeast prion protein ure2 enter vertebrate cells by specific endocytotic pathways and induce apoptosis.
PloS one 2010;5(9):.
2010: Li Fei; Sarah Perrett
New insights into the molecular mechanism of amyloid formation from cysteine scanning.
Prion 2010;4(1):9-12.
2009: Zai-Rong Zhang; Sarah Perrett
Novel glutaredoxin activity of the yeast prion protein Ure2 reveals a native-like dimer within fibrils.
The Journal of biological chemistry 2009;284(21):14058-67.
2009: Li Fei; Sarah Perrett
Disulfide bond formation significantly accelerates the assembly of Ure2p fibrils because of the proximity of a potential amyloid stretch.
The Journal of biological chemistry 2009;284(17):11134-41.
2009: Hong Zhang; Harriët M Loovers; Li-Qiong Xu; Mingzhu Wang; Pamela J E Rowling; Laura S Itzhaki; Weimin Gong; Jun-Mei Zhou; Gary W Jones; Sarah Perrett
Alcohol oxidase (AOX1) from Pichia pastoris is a novel inhibitor of prion propagation and a potential ATPase.
Molecular microbiology 2009;71(3):702-16.
2009: Xin-Yu Wang; Zai-Rong Zhang; Sarah Perrett
Characterization of the activity and folding of the glutathione transferase from Escherichia coli and the roles of residues Cys(10) and His(106).
The Biochemical journal 2009;417(1):55-64.
2008: Zai-Rong Zhang; Ming Bai; Xin-Yu Wang; Jun-Mei Zhou; Sarah Perrett
"Restoration" of glutathione transferase activity by single-site mutation of the yeast prion protein Ure2.
Journal of molecular biology 2008;384(3):641-51.
2008: Sarah Perrett; Gary W Jones
Insights into the mechanism of prion propagation.
Current opinion in structural biology 2008;18(1):52-9.
2007: Lizeng Gao; Jie Zhuang; Leng Nie; Jinbin Zhang; Yu Zhang; Ning Gu; Taihong Wang; Jing Feng; Dongling Yang; Sarah Perrett; Xiyun Yan
Intrinsic peroxidase-like activity of ferromagnetic nanoparticles.
Nature nanotechnology 2007;2(9):577-83.
2007: Yi Shi; Dong-Jie Fan; Shu-Xin Li; Hong-Jie Zhang; Sarah Perrett; Jun-Mei Zhou
Identification of a potential hydrophobic peptide binding site in the C-terminal arm of trigger factor.
Protein science : a publication of the Protein Society 2007;16(6):1165-75.
2007: Huiyong Lian; Hong Zhang; Zai-Rong Zhang; Harriët M Loovers; Gary W Jones; Pamela J E Rowling; Laura S Itzhaki; Jun-Mei Zhou; Sarah Perrett
Hsp40 interacts directly with the native state of the yeast prion protein Ure2 and inhibits formation of amyloid-like fibrils.
The Journal of biological chemistry 2007;282(16):11931-40.
2007: Neil Shaw; Chongyun Cheng; Wolfram Tempel; Jessie Chang; Joseph Ng; Xin-Yu Wang; Sarah Perrett; John Rose; Zihe Rao; Bi-Cheng Wang; Zhi-Jie Liu
(NZ)CH...O contacts assist crystallization of a ParB-like nuclease.
BMC structural biology 2007;7():46.
2006: Li-Ling Zeng; Ling Yu; Zhen-Yu Li; Sarah Perrett; Jun-Mei Zhou
Effect of C-terminal truncation on the molecular chaperone function and dimerization of Escherichia coli trigger factor.
Biochimie 2006;88(6):613-9.
2006: Huiyong Lian; Yi Jiang; Hong Zhang; Gary W Jones; Sarah Perrett
The yeast prion protein Ure2: structure, function and folding.
Biochimica et biophysica acta 2006;1764(3):535-45.
2005: Chuan-Peng Liu; Zhen-Yu Li; Guo-Chang Huang; Sarah Perrett; Jun-Mei Zhou
Two distinct intermediates of trigger factor are populated during guanidine denaturation.
Biochimie 2005;87(11):1023-31.
2005: Chuan-Peng Liu; Sarah Perrett; Jun-Mei Zhou
Dimeric trigger factor stably binds folding-competent intermediates and cooperates with the DnaK-DnaJ-GrpE chaperone system to allow refolding.
The Journal of biological chemistry 2005;280(14):13315-20.
2004: Ming Bai; Jun-Mei Zhou; Sarah Perrett
The yeast prion protein Ure2 shows glutathione peroxidase activity in both native and fibrillar forms.
The Journal of biological chemistry 2004;279(48):50025-30.
2004: Yi Jiang; Hui Li; Li Zhu; Jun-Mei Zhou; Sarah Perrett
Amyloid nucleation and hierarchical assembly of Ure2p fibrils. Role of asparagine/glutamine repeat and nonrepeat regions of the prion domains.
The Journal of biological chemistry 2004;279(5):3361-9.
2003: Li Zhu; Hiroshi Kihara; Masaki Kojima; Jun-Mei Zhou; Sarah Perrett
Small angle X-ray scattering study of the yeast prion Ure2p.
Biochemical and biophysical research communications 2003;311(2):525-32.
2003: Li Zhu; Xu-Jia Zhang; Ling-Yun Wang; Jun-Mei Zhou; Sarah Perrett
Relationship between stability of folding intermediates and amyloid formation for the yeast prion Ure2p: a quantitative analysis of the effects of pH and buffer system.
Journal of molecular biology 2003;328(1):235-54.
2002: Sarah Perrett; Jun-Mei Zhou
Expanding the pressure technique: insights into protein folding from combined use of pressure and chemical denaturants.
Biochimica et biophysica acta 2002;1595(1-2):210-23.
2001: Z J Qin; Y Q Tang; Guozhong Jing; Zhen-Yu Li; Guo-Chang Huang; Sarah Perrett; Z Q Guo; Jun-Mei Zhou
Conformational adjustments of SNase R and its N-terminal fragments probed by monoclonal antibodies.
Biochimica et biophysica acta 2001;1548(2):203-12.