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Norbert Perrimon

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Phillip Karpowicz; Patrick Emery; John B Hogenesch; Yong Zhang; Norbert Perrimon
The circadian clock gates the intestinal stem cell regenerative state.
Giovanni Roti; Angela H Su; Jon C Aster; Stephen C Blacklow; Anne Carlton; Andrew L Kung; Michele Markstein; Kostandin Pajcini; Warren S Pear; Norbert Perrimon; Kenneth N Ross; Kimberly Stegmaier
Complementary genomic screens identify SERCA as a therapeutic target in NOTCH1 mutated cancer.
Arunachalam Vinayagam; Charles Roesel; Richelle Sopko; Yanhui Hu; Meghana Kulkarni; Stephanie E Mohr; Norbert Perrimon
Protein complex-based analysis framework for high-throughput data sets.

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All Publications

2013: Phillip Karpowicz; Patrick Emery; John B Hogenesch; Yong Zhang; Norbert Perrimon
The circadian clock gates the intestinal stem cell regenerative state.
Cell reports 2013;3(4):996-1004.
2013: Giovanni Roti; Angela H Su; Jon C Aster; Stephen C Blacklow; Anne Carlton; Andrew L Kung; Michele Markstein; Kostandin Pajcini; Warren S Pear; Norbert Perrimon; Kenneth N Ross; Kimberly Stegmaier
Complementary genomic screens identify SERCA as a therapeutic target in NOTCH1 mutated cancer.
Cancer cell 2013;23(3):390-405.
2013: Arunachalam Vinayagam; Charles Roesel; Richelle Sopko; Yanhui Hu; Meghana Kulkarni; Stephanie E Mohr; Norbert Perrimon
Protein complex-based analysis framework for high-throughput data sets.
Science signaling 2013;6(264):rs5.
2013: Chrysoula Pitsouli; Norbert Perrimon
The homeobox transcription factor cut coordinates patterning and growth during Drosophila airway remodeling.
Science signaling 2013;6(263):ra12.
2013: Rui Zhou; Gregory J Hannon; Stephanie Mohr; Norbert Perrimon
Inducing RNAi in Drosophila Cells by Transfection with dsRNA.
Cold Spring Harbor protocols 2013;2013(5):.
2013: Akhila Rajan; Norbert Perrimon
Of flies and men: insights on organismal metabolism from fruit flies.
BMC biology 2013;11():38.
2013: Clemens Bergwitz; Jonathan Cohen; Charles DeRobertis; Adam Friedman; Yanhui Hu; Joanne Huang; Meghana Kulkarni; Lawrence B Mensah; Stephanie E Mohr; Lizabeth A Perkins; Michael Schnall-Levin; Sumi Sinha; Arunachalam Vinayagam; Mark J Wee; Bonnie Berger; Norbert Perrimon
Genetic determinants of phosphate response in Drosophila.
PloS one 2013;8(3):e56753.
2013: Johannes T-H Yeh; Richard Binari; Ramanuj Dasgupta; Tenzin Gocha; Norbert Perrimon
PAPTi: a peptide aptamer interference toolkit for perturbation of protein-protein interaction networks.
Scientific reports 2013;3():1156.
2013: Max V Staller; Rong Tao; Zeba B Wunderlich; Dong Yan; Meghan D Bragdon; Angela H DePace; Lizabeth A Perkins; Sakara Randklev; Norbert Perrimon
Depleting gene activities in early Drosophila embryos with the "maternal-Gal4-shRNA" system.
Genetics 2013;193(1):51-61.
2012: Joshua D Stender; Michael Boutros; Kevin Do; Minna U Kaikkonen; Wen Liu; Gabriel Pascual; Norbert Perrimon; Michael G Rosenfeld; Nathanael J Spann; Christopher K Glass
Control of proinflammatory gene programs by regulated trimethylation and demethylation of histone H4K20.
Molecular cell 2012;48(1):28-38.
2012: Akhila Rajan; Norbert Perrimon
Drosophila cytokine unpaired 2 regulates physiological homeostasis by remotely controlling insulin secretion.
Cell 2012;151(1):123-37.
2012: Norbert Perrimon; Chrysoula Pitsouli; Ben-Zion Shilo
Signaling mechanisms controlling cell fate and embryonic patterning.
Cold Spring Harbor perspectives in biology 2012;4(8):a005975.
2012: Fernando Bejarano; Diane Bortolamiol-Becet; Yu-Ting Chou; Qi Dai; Hong Duan; Tudor A Fulga; Kevin Kim; Jian-Quan Ni; Norbert Perrimon; David R Raleigh; Abil Saj; Kailiang Sun; David Van Vactor; Jr-Shiuan Yang; Eric C Lai
A genome-wide transgenic resource for conditional expression of Drosophila microRNAs.
Development (Cambridge, England) 2012;139(15):2821-31.
2012: Subhash D Katewa; Marysia Kolipinski; Simon Melov; Norbert Perrimon; Fabio Demontis; Matthew S Gill; Alan Hubbard; pankaj kapahi
Intramyocellular fatty-acid metabolism plays a critical role in mediating responses to dietary restriction in Drosophila melanogaster.
Cell metabolism 2012;16(1):97-103.
2012: Marion Kusche-Gullberg; Kent Nybakken; Norbert Perrimon; Ulf Lindahl
Drosophila heparan sulfate, a novel design.
The Journal of biological chemistry 2012;287(26):21950-6.
2012: Ralph A Neumüller; Koen J T Venken; Frederik Wirtz-Peitz; Hugo J Bellen; Michael Buckner; Roger A Hoskins; Young Kwon; Stella Lee; Stephanie E Mohr; Norbert Perrimon
Stringent analysis of gene function and protein-protein interactions using fluorescently tagged genes.
Genetics 2012;190(3):931-40.
2012: Stephanie E Mohr; Norbert Perrimon
RNAi screening: new approaches, understandings, and organisms.
Wiley interdisciplinary reviews. RNA 2012;3(2):145-58.
2012: Clemens Bergwitz; Hway H Chen; Charles DeRobertis; Joanne Huang; Matthew D Rasmussen; Sumi Sinha; Mark J Wee; Norbert Perrimon
Roles of major facilitator superfamily transporters in phosphate response in Drosophila.
PloS one 2012;7(2):e31730.
2011: Norbert Perrimon; Naama Barkai
The era of systems developmental biology.
Current opinion in genetics & development 2011;21(6):681-3.
2011: Jennifer L Rohn; Frieder Schöck; David Sims; Maria K Vartiainen; Joseph Dopie; Marina Fedorova; Amy A Kiger; Tao Liu; Norbert Perrimon; Buzz Baum
Comparative RNAi screening identifies a conserved core metazoan actinome by phenotype.
The Journal of cell biology 2011;194(5):789-805.
2011: Michael Schnall-Levin; David P Bartel; Wendy K Johnston; Norbert Perrimon; Olivia S Rissland; Bonnie Berger
Unusually effective microRNA targeting within repeat-rich coding regions of mammalian mRNAs.
Genome research 2011;21(9):1395-403.
2011: Akhila Rajan; Norbert Perrimon
Drosophila as a model for interorgan communication: lessons from studies on energy homeostasis.
Developmental cell 2011;21(1):29-31.
2011: Ralph A Neumüller; Norbert Perrimon
Where gene discovery turns into systems biology: genome-scale RNAi screens in Drosophila.
Wiley interdisciplinary reviews. Systems biology and medicine 2011;3(4):471-8.
2011: Jian-Quan Ni; Rui Zhou; Benjamin Czech; Lu-Ping Liu; Laura Holderbaum; Donghui Yang-Zhou; Hye-Seok Shim; Rong Tao; Dominik Handler; Phillip Karpowicz; Richard Binari; Matthew Booker; Julius Brennecke; Lizabeth A Perkins; Gregory J Hannon; Norbert Perrimon
A genome-scale shRNA resource for transgenic RNAi in Drosophila.
Nature methods 2011;8(5):405-7.
2011: Wing Man Chan; Ho Tsoi; Chi Chung Wu; CHI HANG WONG; Tat Cheung Cheng; Hoi-Yeung Li; Kwok Fai Lau; Pang-Chui Shaw; Norbert Perrimon; Ho Yin Edwin Chan
Expanded polyglutamine domain possesses nuclear export activity which modulates subcellular localization and toxicity of polyQ disease protein via exportin-1.
Human molecular genetics 2011;20(9):1738-50.
2011: William T Gibson; James H Veldhuis; Boris Rubinstein; Heather N Cartwright; Norbert Perrimon; G Wayne Brodland; Radhika Nagpal; Matthew C Gibson
Control of the mitotic cleavage plane by local epithelial topology.
Cell 2011;144(3):427-38.
2011: Eugene Berezikov; Nicolas Robine; Anastasia Samsonova; Jakub O Westholm; Ammar Naqvi; Jui-Hung Hung; Katsutomo Okamura; Qi Dai; Diane Bortolamiol-Becet; Raquel Martin; Yongjun Zhao; Phillip D Zamore; Gregory J Hannon; Marco A Marra; Zhiping Weng; Norbert Perrimon; Eric C Lai
Deep annotation of Drosophila melanogaster microRNAs yields insights into their processing, modification, and emergence.
Genome research 2011;21(2):203-15.
2011: Adam A Friedman; Pengyu Hong; Yanhui Hu; Thilakam Murali; Svetlana Pacifico; John M Asara; Bonnie Berger; Richard Binari; Russell L Finley; Maura Porto; Rohit Singh; Xiaoyun Sun; George Tucker; Arunachalam Vinayagam; Dong Yan; Norbert Perrimon
Proteomic and functional genomic landscape of receptor tyrosine kinase and ras to extracellular signal-regulated kinase signaling.
Science signaling 2011;4(196):rs10.
2011: Yanhui Hu; Bonnie Berger; Clemens Bergwitz; Ian Flockhart; Norbert Perrimon; Arunachalam Vinayagam; Stephanie E Mohr
An integrative approach to ortholog prediction for disease-focused and other functional studies.
BMC bioinformatics 2011;12():357.
2011: Norbert Perrimon; Jonathan Zirin; Jianwu Bai
Primary cell cultures from Drosophila gastrula embryos.
Journal of visualized experiments : JoVE 2011;(48):.
2011: Matthew Booker; Anastasia A Samsonova; Young Kwon; Ian Flockhart; Stephanie E Mohr; Norbert Perrimon
False negative rates in Drosophila cell-based RNAi screens: a case study.
BMC genomics 2011;12():50.
2011: Shu Kondo; Norbert Perrimon
A genome-wide RNAi screen identifies core components of the G₂-M DNA damage checkpoint.
Science signaling 2011;4(154):rs1.
2011: Craig Micchelli; Lisa Sudmeier; Norbert Perrimon; Shan Tang; Ryan Beehler-Evans
Identification of adult midgut precursors in Drosophila.
Gene expression patterns : GEP 2011;11(1-2):12-21.
2010: Phillip Karpowicz; Jessica Perez; Norbert Perrimon
The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration.
Development (Cambridge, England) 2010;137(24):4135-45.
2010: Jonathan Zirin; Norbert Perrimon
Drosophila as a model system to study autophagy.
Seminars in immunopathology 2010;32(4):363-72.
2010: Fabio Demontis; Norbert Perrimon
FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging.
Cell 2010;143(5):813-25.
2010: Yanning Rui; Jianwu Bai; Norbert Perrimon
Sarcomere formation occurs by the assembly of multiple latent protein complexes.
PLoS genetics 2010;6(11):e1001208.
2010: Chrysoula Pitsouli; Norbert Perrimon
Embryonic multipotent progenitors remodel the Drosophila airways during metamorphosis.
Development (Cambridge, England) 2010;137(21):3615-24.
2010: Michael Schnall-Levin; Yong Zhao; Norbert Perrimon; Bonnie Berger
Conserved microRNA targeting in Drosophila is as widespread in coding regions as in 3'UTRs.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(36):15751-6.
2010: Norbert Perrimon; Jian-Quan Ni; Lizabeth Perkins
In vivo RNAi: today and tomorrow.
Cold Spring Harbor perspectives in biology 2010;2(8):a003640.
2010: Akhila Rajan; Norbert Perrimon
Steroids make you bigger? Fat chance says Myc.
Cell metabolism 2010;12(1):7-9.
2010: Lutz Kockel; Kimberly S Kerr; Michael Melnick; Katja Brückner; Matthias Hebrok; Norbert Perrimon
Dynamic switch of negative feedback regulation in Drosophila Akt-TOR signaling.
PLoS genetics 2010;6(6):e1000990.
2010: Sheng Zhang; Richard Binari; Rui Zhou; Norbert Perrimon
A genomewide RNA interference screen for modifiers of aggregates formation by mutant Huntingtin in Drosophila.
Genetics 2010;184(4):1165-79.
2010: Oaz Nir; Chris Bakal; Norbert Perrimon; Bonnie Berger
Inference of RhoGAP/GTPase regulation using single-cell morphological data from a combinatorial RNAi screen.
Genome research 2010;20(3):372-80.
2010: Phillip Karpowicz; Norbert Perrimon
All for one, and one for all: the clonality of the intestinal stem cell niche.
F1000 biology reports 2010;2():73.
2010: Han Yan; Kavitha Venkatesan; John E Beaver; Niels Klitgord; Muhammed A Yildirim; Tong Hao; David E Hill; Michael E Cusick; Norbert Perrimon; Frederick P Roth; Marc Vidal
A genome-wide gene function prediction resource for Drosophila melanogaster.
PloS one 2010;5(8):e12139.
2010: Stephanie Mohr; Chris Bakal; Norbert Perrimon
Genomic screening with RNAi: results and challenges.
Annual review of biochemistry 2010;79():37-64.
2009: Yiorgos Apidianakis; Chrysoula Pitsouli; Norbert Perrimon; Laurence G Rahme
Synergy between bacterial infection and genetic predisposition in intestinal dysplasia.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(49):20883-8.
2009: Xuemei Yang; Adam Friedman; Shailender Nagpal; Norbert Perrimon; John M Asara
Use of a label-free quantitative platform based on MS/MS average TIC to calculate dynamics of protein complexes in insulin signaling.
Journal of biomolecular techniques : JBT 2009;20(5):272-7.
2009: Benjamin Czech; Rui Zhou; Yaniv Erlich; Julius Brennecke; Richard Binari; Christians Villalta; Assaf Gordon; Norbert Perrimon; Gregory J Hannon
Hierarchical rules for Argonaute loading in Drosophila.
Molecular cell 2009;36(3):445-56.
2009: Shu Kondo; Matthew Booker; Norbert Perrimon
Cross-species RNAi rescue platform in Drosophila melanogaster.
Genetics 2009;183(3):1165-73.
2009: Chrysoula Pitsouli; Yiorgos Apidianakis; Norbert Perrimon
Homeostasis in infected epithelia: stem cells take the lead.
Cell host & microbe 2009;6(4):301-7.
2009: Rui Zhou; Benjamin Czech; Julius Brennecke; Ravi Sachidanandam; James Wohlschlegel; Norbert Perrimon; Gregory J Hannon
Processing of Drosophila endo-siRNAs depends on a specific Loquacious isoform.
RNA (New York, N.Y.) 2009;15(10):1886-95.
2009: Eric Brouzes; Martina Medkova; Neal Savenelli; Dave Marran; Mariusz Twardowski; J Brian Hutchison; Jonathan M Rothberg; Darren R Link; Norbert Perrimon; Michael L Samuels
Droplet microfluidic technology for single-cell high-throughput screening.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(34):14195-200.
2009: Ruth Griffin; Anne Sustar; Marianne Bonvin; Richard Binari; Alberto del Valle Rodriguez; Amber M Hohl; Jack R Bateman; Christians Villalta; Elleard Heffern; Didier Grunwald; Chris Bakal; Claude Desplan; Gerold Schubiger; Ting (C.-ting) Wu; Norbert Perrimon
The twin spot generator for differential Drosophila lineage analysis.
Nature methods 2009;6(8):600-2.
2009: Jian-Quan Ni; Lu-Ping Liu; Richard Binari; Robert Hardy; Hye-Seok Shim; Amanda Cavallaro; Matthew Booker; Barret D Pfeiffer; Michele Markstein; Hui Wang; Christians Villalta; Todd R Laverty; Lizabeth A Perkins; Norbert Perrimon
A Drosophila resource of transgenic RNAi lines for neurogenetics.
Genetics 2009;182(4):1089-100.
2009: Irene M Kaplow; Rohit Singh; Adam Friedman; Chris Bakal; Norbert Perrimon; Bonnie Berger
RNAiCut: automated detection of significant genes from functional genomic screens.
Nature methods 2009;6(7):476-7.
2009: Sheng Zhang; Mel B Feany; Sudipta Saraswati; J Troy Littleton; Norbert Perrimon
Inactivation of Drosophila Huntingtin affects long-term adult functioning and the pathogenesis of a Huntington's disease model.
Disease models & mechanisms 2009;2(5-6):247-66.
2009: Fabio Demontis; Norbert Perrimon
Integration of Insulin receptor/Foxo signaling and dMyc activity during muscle growth regulates body size in Drosophila.
Development (Cambridge, England) 2009;136(6):983-93.
2009: J Wang; Xiaobo Zhou; Fuhai Li; Pamela L Bradley; Shih-Fu Chang; Norbert Perrimon; Stephen Wong
An image score inference system for RNAi genome-wide screening based on fuzzy mixture regression modeling.
Journal of biomedical informatics 2009;42(1):32-40.
2009: Jianwu Bai; Katharine J Sepp; Norbert Perrimon
Culture of Drosophila primary cells dissociated from gastrula embryos and their use in RNAi screening.
Nature protocols 2009;4(10):1502-12.
2009: Claudio Vinegoni; Daniel Razansky; Chrysoula Pitsouli; Norbert Perrimon; Vasilis Ntziachristos; Ralph Weissleder
Mesoscopic fluorescence tomography for in-vivo imaging of developing Drosophila.
Journal of visualized experiments : JoVE 2009;(30):.
2008: Rui Zhou; Ikuko Hotta; Ahmet M Denli; Pengyu Hong; Norbert Perrimon; Gregory J Hannon
Comparative analysis of argonaute-dependent small RNA pathways in Drosophila.
Molecular cell 2008;32(4):592-9.
2008: Chris Bakal; Rune Linding; Flora Llense; Elleard Heffern; Enrique Martin-Blanco; Tony Pawson; Norbert Perrimon
Phosphorylation networks regulating JNK activity in diverse genetic backgrounds.
Science (New York, N.Y.) 2008;322(5900):453-6.
2008: Stephane Vincent; Norbert Perrimon; Jeffrey D Axelrod
Hedgehog and Wingless stabilize but do not induce cell fate during Drosophila dorsal embryonic epidermal patterning.
Development (Cambridge, England) 2008;135(16):2767-75.
2008: Chrysoula Pitsouli; Norbert Perrimon
Developmental biology: Our fly cousins' gut.
Nature 2008;454(7204):592-3.
2008: Katharine J Sepp; Pengyu Hong; sofia lizarraga; Judy S Liu; Luis A Mejia; Christopher Walsh; Norbert Perrimon
Identification of neural outgrowth genes using genome-wide RNAi.
PLoS genetics 2008;4(7):e1000111.
2008: Benjamin Czech; Colin D Malone; Rui Zhou; Alexander Stark; Catherine Schlingeheyde; Monica Dus; Norbert Perrimon; Manolis Kellis; James Wohlschlegel; Ravi Sachidanandam; Gregory J Hannon; Julius Brennecke
An endogenous small interfering RNA pathway in Drosophila.
Nature 2008;453(7196):798-802.
2008: Jianwu Bai; Richard Binari; Jian-Quan Ni; Marina Vijayakanthan; Hong-Sheng Li; Norbert Perrimon
RNA interference screening in Drosophila primary cells for genes involved in muscle assembly and maintenance.
Development (Cambridge, England) 2008;135(8):1439-49.
2008: Michele Markstein; Chrysoula Pitsouli; Christians Villalta; Susan E Celniker; Norbert Perrimon
Exploiting position effects and the gypsy retrovirus insulator to engineer precisely expressed transgenes.
Nature genetics 2008;40(4):476-83.
2008: Jennifer A Philips; Maura C Porto; Hui Wang; Eric J Rubin; Norbert Perrimon
ESCRT factors restrict mycobacterial growth.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(8):3070-5.
2008: Zheng Yin; Xiaobo Zhou; Chris Bakal; Fuhai Li; Youxian Sun; Norbert Perrimon; Stephen Wong
Using iterative cluster merging with improved gap statistics to perform online phenotype discovery in the context of high-throughput RNAi screens.
BMC bioinformatics 2008;9():264.
2008: Jun Wang; Xiaobo Zhou; Pamela L Bradley; Shih-Fu Chang; Norbert Perrimon; Stephen Wong
Cellular phenotype recognition for high-content RNA interference genome-wide screening.
Journal of biomolecular screening 2008;13(1):29-39.
2008: Jian-Quan Ni; Michele Markstein; Richard Binari; Barret Pfeiffer; Lu-Ping Liu; Christians Villalta; Matthew Booker; Lizabeth Perkins; Norbert Perrimon
Vector and parameters for targeted transgenic RNA interference in Drosophila melanogaster.
Nature methods 2008;5(1):49-51.
2008: Claudio Vinegoni; Chrysoula Pitsouli; Daniel Razansky; Norbert Perrimon; Vasilis Ntziachristos
In vivo imaging of Drosophila melanogaster pupae with mesoscopic fluorescence tomography.
Nature methods 2008;5(1):45-7.
2007: Jianwu Bai; John H Hartwig; Norbert Perrimon
SALS, a WH2-domain-containing protein, promotes sarcomeric actin filament elongation from pointed ends during Drosophila muscle growth.
Developmental cell 2007;13(6):828-42.
2007: Serena J Silver; Joshua W Hagen; Katsutomo Okamura; Norbert Perrimon; Eric C Lai
Functional screening identifies miR-315 as a potent activator of Wingless signaling.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(46):18151-6.
2007: Pierre Leopold; Norbert Perrimon
Drosophila and the genetics of the internal milieu.
Nature 2007;450(7167):186-8.
2007: Chris Bakal; John Aach; George M Church; Norbert Perrimon
Quantitative morphological signatures define local signaling networks regulating cell morphology.
Science (New York, N.Y.) 2007;316(5832):1753-6.
2007: Jianrong Lu; Marie-Laure Ruhf; Norbert Perrimon; Philip Leder
A genome-wide RNA interference screen identifies putative chromatin regulators essential for E2F repression.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(22):9381-6.
2007: Bernard Mathey-Prevot; Norbert Perrimon
Do-it-yourself RNAi made easy?
Nature methods 2007;4(4):308-9.
2007: Adam Friedman; Norbert Perrimon
Genetic screening for signal transduction in the era of network biology.
Cell 2007;128(2):225-31.
2007: Norbert Perrimon; Bernard Mathey-Prevot
Matter arising: off-targets and genome-scale RNAi screens in Drosophila.
Fly 2007;1(1):1-5.
2007: Ramanuj DasGupta; Kent Nybakken; Matthew Booker; Bernard Mathey-Prevot; Foster Gonsalves; Binita Changkakoty; Norbert Perrimon
A case study of the reproducibility of transcriptional reporter cell-based RNAi screens in Drosophila.
Genome biology 2007;8(9):R203.
2007: Nadire Ramadan; Ian Flockhart; Matthew Booker; Norbert Perrimon; Bernard Mathey-Prevot
Design and implementation of high-throughput RNAi screens in cultured Drosophila cells.
Nature protocols 2007;2(9):2245-64.
2007: Norbert Perrimon; Bernard Mathey-Prevot
Applications of high-throughput RNA interference screens to problems in cell and developmental biology.
Genetics 2007;175(1):7-16.
2007: Norbert Perrimon; Adam Friedman; Bernard Mathey-Prevot; Ulrike S Eggert
Drug-target identification in Drosophila cells: combining high-throughout RNAi and small-molecule screens.
Drug discovery today 2007;12(1-2):28-33.
2007: Erika A Bach; Laura A Ekas; Aidee Ayala-Camargo; Maria Sol Flaherty; Haeryun Lee; Norbert Perrimon; Gyeong-Hun Baeg
GFP reporters detect the activation of the Drosophila JAK/STAT pathway in vivo.
Gene expression patterns : GEP 2007;7(3):323-31.
2006: Adam Friedman; Norbert Perrimon
A functional RNAi screen for regulators of receptor tyrosine kinase and ERK signalling.
Nature 2006;444(7116):230-4.
2006: Adam Friedman; Norbert Perrimon
High-throughput approaches to dissecting MAPK signaling pathways.
Methods (San Diego, Calif.) 2006;40(3):262-71.
2006: Sara Cherry; Amit Kunte; Hui Wang; Carolyn Coyne; Robert B Rawson; Norbert Perrimon
COPI activity coupled with fatty acid biosynthesis is required for viral replication.
PLoS pathogens 2006;2(10):e102.
2006: Christophe Echeverri; Philip A Beachy; Buzz Baum; Michael Boutros; Frank Buchholz; Sumit K Chanda; Julian Downward; Jan Ellenberg; Andrew G Fraser; Nir Hacohen; William C Hahn; Aimee L Jackson; Amy Kiger; Peter Linsley; Lawrence Lum; Yong Ma; Bernard Mathey-Prévôt; David E Root; David M Sabatini; Jussi Taipale; Norbert Perrimon; René Bernards
Minimizing the risk of reporting false positives in large-scale RNAi screens.
Nature methods 2006;3(10):777-9.
2006: Meghana M Kulkarni; Matthew Booker; Serena J Silver; Adam Friedman; Pengyu Hong; Norbert Perrimon; Bernard Mathey-Prevot
Evidence of off-target effects associated with long dsRNAs in Drosophila melanogaster cell-based assays.
Nature methods 2006;3(10):833-8.
2006: Matthew C Gibson; Ankit B Patel; Radhika Nagpal; Norbert Perrimon
The emergence of geometric order in proliferating metazoan epithelia.
Nature 2006;442(7106):1038-41.
2006: Li-Ying Chen; Juinn-Chin Wang; Yann Hyvert; Hui-Ping Lin; Norbert Perrimon; Yann Hyvert; Jui-Chou Hsu
Weckle is a zinc finger adaptor of the toll pathway in dorsoventral patterning of the Drosophila embryo.
Current biology : CB 2006;16(12):1183-93.
2006: Peter Karsten; Iris Plischke; Norbert Perrimon; Martin P Zeidler
Mutational analysis reveals separable DNA binding and trans-activation of Drosophila STAT92E.
Cellular signalling 2006;18(6):819-29.
2006: Christophe J Echeverri; Norbert Perrimon
High-throughput RNAi screening in cultured cells: a user's guide.
Nature reviews. Genetics 2006;7(5):373-84.
2006: Frederic Bard; Laetitia Casano; Arrate Mallabiabarrena; Erin Wallace; Kota Saito; Hitoshi Kitayama; Gianni Guizzunti; Yue Hu; Franz Wendler; Ramanuj Dasgupta; Norbert Perrimon; Vivek Malhotra
Functional genomics reveals genes involved in protein secretion and Golgi organization.
Nature 2006;439(7076):604-7.
2006: Craig Micchelli; Norbert Perrimon
Evidence that stem cells reside in the adult Drosophila midgut epithelium.
Nature 2006;439(7075):475-9.
2006: Bernard Mathey-Prevot; Norbert Perrimon
Drosophila genome-wide RNAi screens: are they delivering the promise?
Cold Spring Harbor symposia on quantitative biology 2006;71():141-8.
2006: Ian Flockhart; Matthew Booker; Amy Kiger; Michael Boutros; Susan Armknecht; Nadire Ramadan; Kris Richardson; Andrew Xu; Norbert Perrimon; Bernard Mathey-Prevot
FlyRNAi: the Drosophila RNAi screening center database.
Nucleic acids research 2006;34(Database issue):D489-94.
2005: Kent Nybakken; Steven A Vokes; Ting-Yi Lin; Andrew P McMahon; Norbert Perrimon
A genome-wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway.
Nature genetics 2005;37(12):1323-32.
2005: Daniel Kirilly; Eric P Spana; Norbert Perrimon; Richard W Padgett; Ting Xie
BMP signaling is required for controlling somatic stem cell self-renewal in the Drosophila ovary.
Developmental cell 2005;9(5):651-62.
2005: Jennifer A Philips; Eric J Rubin; Norbert Perrimon
Drosophila RNAi screen reveals CD36 family member required for mycobacterial infection.
Science (New York, N.Y.) 2005;309(5738):1251-3.
2005: Hervé Agaisse; Laura S Burrack; Jennifer A Philips; Eric J Rubin; Norbert Perrimon; Darren E Higgins
Genome-wide RNAi screen for host factors required for intracellular bacterial infection.
Science (New York, N.Y.) 2005;309(5738):1248-51.
2005: Gyeong-Hun Baeg; Rui Zhou; Norbert Perrimon
Genome-wide RNAi analysis of JAK/STAT signaling components in Drosophila.
Genes & development 2005;19(16):1861-70.
2005: Markus Schober; Ilaria Rebay; Norbert Perrimon
Function of the ETS transcription factor Yan in border cell migration.
Development (Cambridge, England) 2005;132(15):3493-504.
2005: Norbert Perrimon
Norbert Perrimon.
Current biology : CB 2005;15(13):R481-2.
2005: Udo Häcker; Kent Nybakken; Norbert Perrimon
Heparan sulphate proteoglycans: the sweet side of development.
Nature reviews. Molecular cell biology 2005;6(7):530-41.
2005: Ramanuj Dasgupta; Michael Boutros; Norbert Perrimon
Drosophila Wnt/Fz pathways.
Science's STKE : signal transduction knowledge environment 2005;2005(283):cm5.
2005: Ramanuj Dasgupta; Ajamete Kaykas; Randall T Moon; Norbert Perrimon
Functional genomic analysis of the Wnt-wingless signaling pathway.
Science (New York, N.Y.) 2005;308(5723):826-33.
2005: Meghana M Kulkarni; Norbert Perrimon
Super-size flies.
Cell metabolism 2005;1(5):288-90.
2005: Penelope Hayward; Keith Brennan; Phil Sanders; Tina Balayo; Ramanuj DasGupta; Norbert Perrimon; Alfonso Martinez-Arias
Notch modulates Wnt signalling by associating with Armadillo/beta-catenin and regulating its transcriptional activity.
Development (Cambridge, England) 2005;132(8):1819-30.
2005: Matthew C Gibson; Norbert Perrimon
Extrusion and death of DPP/BMP-compromised epithelial cells in the developing Drosophila wing.
Science (New York, N.Y.) 2005;307(5716):1785-9.
2005: Sara Cherry; Tammy Doukas; Susan Armknecht; Sean Whelan; Hui Wang; Peter Sarnow; Norbert Perrimon
Genome-wide RNAi screen reveals a specific sensitivity of IRES-containing RNA viruses to host translation inhibition.
Genes & development 2005;19(4):445-52.
2005: Susan Armknecht; Michael Boutros; Amy Kiger; Kent Nybakken; Bernard Mathey-Prevot; Norbert Perrimon
High-throughput RNA interference screens in Drosophila tissue culture cells.
Methods in enzymology 2005;392():55-73.
2004: Ulrike S Eggert; Amy A Kiger; Constance Richter; Zachary E Perlman; Norbert Perrimon; Timothy J Mitchison; Christine M Field
Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets.
PLoS biology 2004;2(12):e379.
2004: Gyeong-Hun Baeg; Erica M Selva; Robyn M Goodman; Ramanuj Dasgupta; Norbert Perrimon
The Wingless morphogen gradient is established by the cooperative action of Frizzled and Heparan Sulfate Proteoglycan receptors.
Developmental biology 2004;276(1):89-100.
2004: Ramanuj Dasgupta; Norbert Perrimon
Using RNAi to catch Drosophila genes in a web of interactions: insights into cancer research.
Oncogene 2004;23(51):8359-65.
2004: Ayelet Schlesinger; Amy Kiger; Norbert Perrimon; Ben-Zion Shilo
Small wing PLCgamma is required for ER retention of cleaved Spitz during eye development in Drosophila.
Developmental cell 2004;7(4):535-45.
2004: Adam Friedman; Norbert Perrimon
Genome-wide high-throughput screens in functional genomics.
Current opinion in genetics & development 2004;14(5):470-6.
2004: Sergey A Sinenko; Eun Kyung Kim; Rhoda Wynn; pascal manfruelli; Istvan Ando; Kristi A Wharton; Norbert Perrimon; Bernard Mathey-Prevot
Yantar, a conserved arginine-rich protein is involved in Drosophila hemocyte development.
Developmental biology 2004;273(1):48-62.
2004: Katja Brückner; Lutz Kockel; Peter Duchek; Carlos M Luque; Pernille Rørth; Norbert Perrimon
The PDGF/VEGF receptor controls blood cell survival in Drosophila.
Developmental cell 2004;7(1):73-84.
2004: Martin P Zeidler; Change Tan; Yohanns Bellaiche; Sara Cherry; Sabine Häder; Urte Gayko; Norbert Perrimon
Temperature-sensitive control of protein activity by conditionally splicing inteins.
Nature biotechnology 2004;22(7):871-6.
2004: Norbert Perrimon; Udo Häcker
Wingless, hedgehog and heparan sulfate proteoglycans.
Development (Cambridge, England) 2004;131(11):2509-11; author reply 2511-3.
2004: Hervé Agaisse; Norbert Perrimon
The roles of JAK/STAT signaling in Drosophila immune responses.
Immunological reviews 2004;198():72-82.
2004: Michael Boutros; Amy Kiger; Susan Armknecht; Kim Kerr; Marc Hild; Britta Koch; Stefan A Haas; Renato Paro; Norbert Perrimon
Genome-wide RNAi analysis of growth and viability in Drosophila cells.
Science (New York, N.Y.) 2004;303(5659):832-5.
2004: Sara Cherry; Norbert Perrimon
Entry is a rate-limiting step for viral infection in a Drosophila melanogaster model of pathogenesis.
Nature immunology 2004;5(1):81-7.
2003: Matthew C Gibson; Norbert Perrimon
Apicobasal polarization: epithelial form and function.
Current opinion in cell biology 2003;15(6):747-52.
2003: Erika A Bach; Stephane Vincent; Martin P Zeidler; Norbert Perrimon
A sensitized genetic screen to identify novel regulators and components of the Drosophila janus kinase/signal transducer and activator of transcription pathway.
Genetics 2003;165(3):1149-66.
2003: Takeshi Sasamura; Nobuo Sasaki; Fumiyasu Miyashita; Shiho Nakao; Hiroyuki O Ishikawa; Mikiko Ito; Motoo Kitagawa; Kenichi Harigaya; Eric Spana; David Bilder; Norbert Perrimon; Kenji Matsuno
neurotic, a novel maternal neurogenic gene, encodes an O-fucosyltransferase that is essential for Notch-Delta interactions.
Development (Cambridge, England) 2003;130(20):4785-95.
2003: Hervé Agaisse; Ulla Maja Petersen; Michael Boutros; Bernard Mathey-Prevot; Norbert Perrimon
Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury.
Developmental cell 2003;5(3):441-50.
2003: Christian Ghiglione; Laufey T Amundadottir; Margret B Andresdottir; David Bilder; John A Diamonti; Stéphane Noselli; Norbert Perrimon; Kermit L Carraway III
Mechanism of inhibition of the Drosophila and mammalian EGF receptors by the transmembrane protein Kekkon 1.
Development (Cambridge, England) 2003;130(18):4483-93.
2003: Florian Lüders; Hiroaki Segawa; David Stein; Erica M Selva; Norbert Perrimon; Salvatore J Turco; Udo Häcker
Slalom encodes an adenosine 3'-phosphate 5'-phosphosulfate transporter essential for development in Drosophila.
The EMBO journal 2003;22(14):3635-44.
2003: Arash Bashirullah; Amy E Pasquinelli; Amy A Kiger; Norbert Perrimon; Gary Ruvkun; Carl S Thummel
Coordinate regulation of small temporal RNAs at the onset of Drosophila metamorphosis.
Developmental biology 2003;259(1):1-8.
2003: Géza Adám; Norbert Perrimon; Stéphane Noselli
The retinoic-like juvenile hormone controls the looping of left-right asymmetric organs in Drosophila.
Development (Cambridge, England) 2003;130(11):2397-406.
2003: Frieder Schöck; Norbert Perrimon
Retraction of the Drosophila germ band requires cell-matrix interaction.
Genes & development 2003;17(5):597-602.
2003: Andras Nagy; Norbert Perrimon; Suzanne Sandmeyer; Ronald H Plasterk
Tailoring the genome: the power of genetic approaches.
Nature genetics 2003;33 Suppl():276-84.
2003: Change Tan; Beth Stronach; Norbert Perrimon
Roles of myosin phosphatase during Drosophila development.
Development (Cambridge, England) 2003;130(4):671-81.
2003: Amy Kiger; Buzz Baum; S Jones; M R Jones; A Coulson; Christophe Echeverri; Norbert Perrimon
A functional genomic analysis of cell morphology using RNA interference.
Journal of biology 2003;2(4):27.
2003: David Bilder; Markus Schober; Norbert Perrimon
Integrated activity of PDZ protein complexes regulates epithelial polarity.
Nature cell biology 2003;5(1):53-8.
2003: Craig Micchelli; William P Esler; W Taylor Kimberly; Christine Jack; Oksana Berezovska; Anna Y Kornilova; Bradley T Hyman; Norbert Perrimon; Michael S Wolfe
Gamma-secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(1):79-81.
2002: Kent Nybakken; Norbert Perrimon
Heparan sulfate proteoglycan modulation of developmental signaling in Drosophila.
Biochimica et biophysica acta 2002;1573(3):280-91.
2002: Ho-Juhn Song; Jean-Christophe Billeter; Enrique Reynaud; Troy Carlo; Eric P Spana; Norbert Perrimon; Stephen F Goodwin; Bruce S Baker; Barbara J Taylor
The fruitless gene is required for the proper formation of axonal tracts in the embryonic central nervous system of Drosophila.
Genetics 2002;162(4):1703-24.
2002: Steven X Hou; Zhiyu Zheng; Xiu Chen; Norbert Perrimon
The Jak/STAT pathway in model organisms: emerging roles in cell movement.
Developmental cell 2002;3(6):765-78.
2002: Zachary Wills; Mark Emerson; Jannette Rusch; Jay Bikoff; Buzz Baum; Norbert Perrimon; David Van Vactor
A Drosophila homolog of cyclase-associated proteins collaborates with the Abl tyrosine kinase to control midline axon pathfinding.
Neuron 2002;36(4):611-22.
2002: Michael Boutros; Hervé Agaisse; Norbert Perrimon
Sequential activation of signaling pathways during innate immune responses in Drosophila.
Developmental cell 2002;3(5):711-22.
2002: Kent Nybakken; Norbert Perrimon
Hedgehog signal transduction: recent findings.
Current opinion in genetics & development 2002;12(5):503-11.
2002: Lori Hrdlicka; Matthew Gibson; Amy Kiger; Craig Micchelli; Markus Schober; Frieder Schöck; Norbert Perrimon
Analysis of twenty-four Gal4 lines in Drosophila melanogaster.
Genesis (New York, N.Y. : 2000) 2002;34(1-2):51-7.
2002: Markus Schober; Norbert Perrimon
Unconventional ways to travel.
Nature cell biology 2002;4(9):E211-2.
2002: Willis X Li; Hervé Agaisse; Bernard Mathey-Prevot; Norbert Perrimon
Differential requirement for STAT by gain-of-function and wild-type receptor tyrosine kinase Torso in Drosophila.
Development (Cambridge, England) 2002;129(18):4241-8.
2002: Frieder Schöck; Norbert Perrimon
Cellular processes associated with germ band retraction in Drosophila.
Developmental biology 2002;248(1):29-39.
2002: Randall T Moon; Bruce Bowerman; Michael Boutros; Norbert Perrimon
The promise and perils of Wnt signaling through beta-catenin.
Science (New York, N.Y.) 2002;296(5573):1644-6.
2002: Xinhua Lin; Norbert Perrimon
Developmental roles of heparan sulfate proteoglycans in Drosophila.
Glycoconjugate journal 2002;19(4-5):363-8.
2002: Dennis Mathew; L Sian Gramates; Mary Packard; Ulrich Thomas; David Bilder; Norbert Perrimon; Michael Gorczyca; Vivian Budnik
Recruitment of scribble to the synaptic scaffolding complex requires GUK-holder, a novel DLG binding protein.
Current biology : CB 2002;12(7):531-9.
2002: Hua-Wei Chen; Maria Julia Marinissen; Su-Wan Oh; Xiu Chen; Michael Melnick; Norbert Perrimon; J Silvio Gutkind; Steven X Hou
CKA, a novel multidomain protein, regulates the JUN N-terminal kinase signal transduction pathway in Drosophila.
Molecular and cellular biology 2002;22(6):1792-803.
2002: Craig Micchelli; Inge The; Erica M Selva; Vladic Mogila; Norbert Perrimon
Rasp, a putative transmembrane acyltransferase, is required for Hedgehog signaling.
Development (Cambridge, England) 2002;129(4):843-51.
2002: Beth Stronach; Norbert Perrimon
Activation of the JNK pathway during dorsal closure in Drosophila requires the mixed lineage kinase, slipper.
Genes & development 2002;16(3):377-87.
2002: Frieder Schock; Norbert Perrimon
Molecular mechanisms of epithelial morphogenesis.
Annual review of cell and developmental biology 2002;18():463-93.
2002: Christian Ghiglione; Erika A Bach; Yolande Paraiso; Kermit L Carraway; Stéphane Noselli; Norbert Perrimon
Mechanism of activation of the Drosophila EGF Receptor by the TGFalpha ligand Gurken during oogenesis.
Development (Cambridge, England) 2002;129(1):175-86.
2001: Y Hong; B Stronach; Norbert Perrimon; Lily Yeh Jan; Yuh Nung Jan
Drosophila Stardust interacts with Crumbs to control polarity of epithelia but not neuroblasts.
Nature 2001;414(6864):634-8.
2001: Buzz Baum; Norbert Perrimon
Spatial control of the actin cytoskeleton in Drosophila epithelial cells.
Nature cell biology 2001;3(10):883-90.
2001: Erica M Selva; K Hong; Gyeong-Hun Baeg; S M Beverley; S J Turco; Norbert Perrimon; Udo Häcker
Dual role of the fringe connection gene in both heparan sulphate and fringe-dependent signalling events.
Nature cell biology 2001;3(9):809-15.
2001: S Vincent; L A Perkins; Norbert Perrimon
Doublesex surprises.
Cell 2001;106(4):399-402.
2001: Beth Stronach; Norbert Perrimon
Investigation of leading edge formation at the interface of amnioserosa and dorsal ectoderm in the Drosophila embryo.
Development (Cambridge, England) 2001;128(15):2905-13.
2001: Erica M Selva; Norbert Perrimon
Role of heparan sulfate proteoglycans in cell signaling and cancer.
Advances in cancer research 2001;83():67-80.
2001: Gyeong-Hun Baeg; X Lin; N Khare; Stefan Baumgartner; Norbert Perrimon
Heparan sulfate proteoglycans are critical for the organization of the extracellular distribution of Wingless.
Development (Cambridge, England) 2001;128(1):87-94.
2000: Martin P Zeidler; Norbert Perrimon; DI Strutt
Multiple roles for four-jointed in planar polarity and limb patterning.
Developmental biology 2000;228(2):181-96.
2000: Elizabeth Noll; Miguel Medina; D Hartley; J Zhou; Norbert Perrimon; Kenneth S Kosik
Presenilin affects arm/beta-catenin localization and function in Drosophila.
Developmental biology 2000;227(2):450-64.
2000: Willis X Li; Elizabeth Noll; Norbert Perrimon
Identification of autosomal regions involved in Drosophila Raf function.
Genetics 2000;156(2):763-74.
2000: Gyeong-Hun Baeg; Norbert Perrimon
Functional binding of secreted molecules to heparan sulfate proteoglycans in Drosophila.
Current opinion in cell biology 2000;12(5):575-80.
2000: Martin P Zeidler; Norbert Perrimon
Sex determination: co-opted signals determine gender.
Current biology : CB 2000;10(18):R682-4.
2000: Buzz Baum; Willis X Li; Norbert Perrimon
A cyclase-associated protein regulates actin and cell polarity during Drosophila oogenesis and in yeast.
Current biology : CB 2000;10(16):964-73.
2000: Xinhua Lin; Norbert Perrimon
Role of heparan sulfate proteoglycans in cell-cell signaling in Drosophila.
Matrix biology : journal of the International Society for Matrix Biology 2000;19(4):303-7.
2000: David Bilder; Mingwei Li; Norbert Perrimon
Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors.
Science (New York, N.Y.) 2000;289(5476):113-6.
2000: Martin P Zeidler; Erika A Bach; Norbert Perrimon
The roles of the Drosophila JAK/STAT pathway.
Oncogene 2000;19(21):2598-606.
2000: Norbert Perrimon; Merton Bernfield
Specificities of heparan sulphate proteoglycans in developmental processes.
Nature 2000;404(6779):725-8.
2000: Michael Boutros; Norbert Perrimon
Drosophila genome takes flight.
Nature cell biology 2000;2(4):E53-4.
2000: David Bilder; Norbert Perrimon
Localization of apical epithelial determinants by the basolateral PDZ protein Scribble.
Nature 2000;403(6770):676-80.
1999: Martin P Zeidler; Norbert Perrimon; DI Strutt
The four-jointed gene is required in the Drosophila eye for ommatidial polarity specification.
Current biology : CB 1999;9(23):1363-72.
1999: Enrique Martín-Blanco; Fernando Roch; E Noll; Antonio Baonza; J B Duffy; Norbert Perrimon
A temporal switch in DER signaling controls the specification and differentiation of veins and interveins in the Drosophila wing.
Development (Cambridge, England) 1999;126(24):5739-47.
1999: Beth Stronach; Norbert Perrimon
Stress signaling in Drosophila.
Oncogene 1999;18(45):6172-82.
1999: Inge The; Yohanns Bellaiche; Norbert Perrimon
Hedgehog movement is regulated through tout velu-dependent synthesis of a heparan sulfate proteoglycan.
Molecular cell 1999;4(4):633-9.
1999: X Lin; Eugene Buff; Norbert Perrimon; Alan M Michelson
Heparan sulfate proteoglycans are essential for FGF receptor signaling during Drosophila embryonic development.
Development (Cambridge, England) 1999;126(17):3715-23.
1999: E Spana; Norbert Perrimon
The latest in signal transduction, 1999. Specificity in Signal Transduction, Keystone, Colorado, USA, 9-14 April 1999.
Trends in genetics : TIG 1999;15(8):301-2.
1999: X Lin; Norbert Perrimon
Dally cooperates with Drosophila Frizzled 2 to transduce Wingless signalling.
Nature 1999;400(6741):281-4.
1999: Yohanns Bellaiche; Vladic Mogila; Norbert Perrimon
I-SceI endonuclease, a new tool for studying DNA double-strand break repair mechanisms in Drosophila.
Genetics 1999;152(3):1037-44.
1999: Martin P Zeidler; Norbert Perrimon; DI Strutt
Polarity determination in the Drosophila eye: a novel role for unpaired and JAK/STAT signaling.
Genes & development 1999;13(10):1342-53.
1999: Norbert Perrimon; Andrew P McMahon
Negative feedback mechanisms and their roles during pattern formation.
Cell 1999;97(1):13-6.
1999: Christian Ghiglione; Kermit L Carraway; Laufey T Amundadottir; R E Boswell; Norbert Perrimon; J B Duffy
The transmembrane molecule kekkon 1 acts in a feedback loop to negatively regulate the activity of the Drosophila EGF receptor during oogenesis.
Cell 1999;96(6):847-56.
1999: Urte Gayko; Vaughn Cleghon; Terry D Copeland; Deborah K Morrison; Norbert Perrimon
Synergistic activities of multiple phosphotyrosine residues mediate full signaling from the Drosophila Torso receptor tyrosine kinase.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(2):523-8.
1999: Vladic Mogila; Yohanns Bellaiche; Norbert Perrimon
Expression of I-Sce I in Drosophila to induce DNA double-strand breaks.
Methods in molecular biology (Clifton, N.J.) 1999;113():439-45.
1999: Christian Ghiglione; Norbert Perrimon; L A Perkins
Quantitative variations in the level of MAPK activity control patterning of the embryonic termini in Drosophila.
Developmental biology 1999;205(1):181-93.
1998: Vaughn Cleghon; Pascale Feldmann; C Ghiglione; Terry D Copeland; Norbert Perrimon; David A Hughes; Deborah K Morrison
Opposing actions of CSW and RasGAP modulate the strength of Torso RTK signaling in the Drosophila terminal pathway.
Molecular cell 1998;2(6):719-27.
1998: Willis X Li; M Melnick; Norbert Perrimon
Dual function of Ras in Raf activation.
Development (Cambridge, England) 1998;125(24):4999-5008.
1998: Joshua M Shulman; Norbert Perrimon; Jeffrey D Axelrod
Frizzled signaling and the developmental control of cell polarity.
Trends in genetics : TIG 1998;14(11):452-8.
1998: D A Harrison; P E McCoon; R Binari; M Gilman; Norbert Perrimon
Drosophila unpaired encodes a secreted protein that activates the JAK signaling pathway.
Genes & development 1998;12(20):3252-63.
1998: Norbert Perrimon
New advances in Drosophila provide opportunities to study gene functions.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(17):9716-7.
1998: Jeffrey D Axelrod; J R Miller; Joshua M Shulman; Randall T Moon; Norbert Perrimon
Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways.
Genes & development 1998;12(16):2610-22.
1998: Yohanns Bellaiche; Inge The; Norbert Perrimon
Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion.
Nature 1998;394(6688):85-8.
1998: Norbert Perrimon; Roel Nusse
Highlights of the 1998 Wnt meeting, Cambridge, MA, January 9-11.
Biochimica et biophysica acta 1998;1377(3):R45-9.
1998: J B Duffy; D A Harrison; Norbert Perrimon
Identifying loci required for follicular patterning using directed mosaics.
Development (Cambridge, England) 1998;125(12):2263-71.
1998: Udo Häcker; Norbert Perrimon
DRhoGEF2 encodes a member of the Dbl family of oncogenes and controls cell shape changes during gastrulation in Drosophila.
Genes & development 1998;12(2):274-84.
1998: Norbert Perrimon
Creating mosaics in Drosophila.
The International journal of developmental biology 1998;42(3):243-7.
1997: Daniel F Eberl; Geoffrey Duyk; Norbert Perrimon
A genetic screen for mutations that disrupt an auditory response in Drosophila melanogaster.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(26):14837-42.
1997: Willis X Li; E M Skoulakis; R L Davis; Norbert Perrimon
The Drosophila 14-3-3 protein Leonardo enhances Torso signaling through D-Raf in a Ras 1-dependent manner.
Development (Cambridge, England) 1997;124(20):4163-71.
1997: S Goode; Norbert Perrimon
Inhibition of patterned cell shape change and cell invasion by Discs large during Drosophila oogenesis.
Genes & development 1997;11(19):2532-44.
1997: Udo Häcker; X Lin; Norbert Perrimon
The Drosophila sugarless gene modulates Wingless signaling and encodes an enzyme involved in polysaccharide biosynthesis.
Development (Cambridge, England) 1997;124(18):3565-73.
1997: XS Hou; E S Goldstein; Norbert Perrimon
Drosophila Jun relays the Jun amino-terminal kinase signal transduction pathway to the Decapentaplegic signal transduction pathway in regulating epithelial cell sheet movement.
Genes & development 1997;11(13):1728-37.
1997: Daniel F Eberl; LJ Lorenz; M B Melnick; V Sood; Paul Lasko; Norbert Perrimon
A new enhancer of position-effect variegation in Drosophila melanogaster encodes a putative RNA helicase that binds chromosomes and is regulated by the cell cycle.
Genetics 1997;146(3):951-63.
1997: Norbert Perrimon; L A Perkins
There must be 50 ways to rule the signal: the case of the Drosophila EGF receptor.
Cell 1997;89(1):13-6.
1997: XS Hou; Norbert Perrimon
The JAK-STAT pathway in Drosophila.
Trends in genetics : TIG 1997;13(3):105-10.
1997: S Goode; Norbert Perrimon
Brainiac and fringe are similar pioneer proteins that impart specificity to notch signaling during Drosophila development.
Cold Spring Harbor symposia on quantitative biology 1997;62():177-84.
1996: T Kadowaki; E Wilder; J Klingensmith; K Zachary; Norbert Perrimon
The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing.
Genes & development 1996;10(24):3116-28.
1996: S Goode; M Melnick; T B Chou; Norbert Perrimon
The neurogenic genes egghead and brainiac define a novel signaling pathway essential for epithelial morphogenesis during Drosophila oogenesis.
Development (Cambridge, England) 1996;122(12):3863-79.
1996: Norbert Perrimon; A Lanjuin; C Arnold; E Noll
Zygotic lethal mutations with maternal effect phenotypes in Drosophila melanogaster. II. Loci on the second and third chromosomes identified by P-element-induced mutations.
Genetics 1996;144(4):1681-92.
1996: T B Chou; Norbert Perrimon
The autosomal FLP-DFS technique for generating germline mosaics in Drosophila melanogaster.
Genetics 1996;144(4):1673-9.
1996: L A Perkins; M R Johnson; M B Melnick; Norbert Perrimon
The nonreceptor protein tyrosine phosphatase corkscrew functions in multiple receptor tyrosine kinase pathways in Drosophila.
Developmental biology 1996;180(1):63-81.
1996: M Musacchio; Norbert Perrimon
The Drosophila kekkon genes: novel members of both the leucine-rich repeat and immunoglobulin superfamilies expressed in the CNS.
Developmental biology 1996;178(1):63-76.
1996: Norbert Perrimon
Serpentine proteins slither into the wingless and hedgehog fields.
Cell 1996;86(4):513-6.
1996: J B Duffy; Norbert Perrimon
Recent advances in understanding signal transduction pathways in worms and flies.
Current opinion in cell biology 1996;8(2):231-8.
1996: Jeffrey D Axelrod; K Matsuno; S Artavanis-Tsakonas; Norbert Perrimon
Interaction between Wingless and Notch signaling pathways mediated by dishevelled.
Science (New York, N.Y.) 1996;271(5257):1826-32.
1996: Vaughn Cleghon; U Gayko; T D Copeland; L A Perkins; Norbert Perrimon; Deborah K Morrison
Drosophila terminal structure development is regulated by the compensatory activities of positive and negative phosphotyrosine signaling sites on the Torso RTK.
Genes & development 1996;10(5):566-77.
1996: X S Hou; M B Melnick; Norbert Perrimon
Marelle acts downstream of the Drosophila HOP/JAK kinase and encodes a protein similar to the mammalian STATs.
Cell 1996;84(3):411-9.
1995: Norbert Perrimon; Xiangyi Lu; X S Hou; J C Hsu; M B Melnick; T B Chou; L A Perkins
Dissection of the Torso signal transduction pathway in Drosophila.
Molecular reproduction and development 1995;42(4):515-22.
1995: A S Manoukian; K B Yoffe; E L Wilder; Norbert Perrimon
The porcupine gene is required for wingless autoregulation in Drosophila.
Development (Cambridge, England) 1995;121(12):4037-44.
1995: Sergei Y Sokol; J Klingensmith; Norbert Perrimon; K Itoh
Dorsalizing and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog of dishevelled.
Development (Cambridge, England) 1995;121(10):3487.
1995: Jerry C P Yin; J S Wallach; E L Wilder; J Klingensmith; Duyen T Dang; Norbert Perrimon; H Zhou; T Tully; W G Quinn
A Drosophila CREB/CREM homolog encodes multiple isoforms, including a cyclic AMP-dependent protein kinase-responsive transcriptional activator and antagonist.
Molecular and cellular biology 1995;15(9):5123-30.
1995: K B Yoffe; A S Manoukian; E L Wilder; A H Brand; Norbert Perrimon
Evidence for engrailed-independent wingless autoregulation in Drosophila.
Developmental biology 1995;170(2):636-50.
1995: D A Harrison; R Binari; T S Nahreini; M Gilman; Norbert Perrimon
Activation of a Drosophila Janus kinase (JAK) causes hematopoietic neoplasia and developmental defects.
The EMBO journal 1995;14(12):2857-65.
1995: Sergei Y Sokol; J Klingensmith; Norbert Perrimon; Keiji Itoh
Dorsalizing and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog of dishevelled.
Development (Cambridge, England) 1995;121(6):1637-47.
1995: X S Hou; T B Chou; M B Melnick; Norbert Perrimon
The torso receptor tyrosine kinase can activate Raf in a Ras-independent pathway.
Cell 1995;81(1):63-71.
1995: Norbert Perrimon
Hedgehog and beyond.
Cell 1995;80(4):517-20.
1995: E L Wilder; Norbert Perrimon
Dual functions of wingless in the Drosophila leg imaginal disc.
Development (Cambridge, England) 1995;121(2):477-88.
1994: J B Duffy; Norbert Perrimon
The torso pathway in Drosophila: lessons on receptor tyrosine kinase signaling and pattern formation.
Developmental biology 1994;166(2):380-95.
1994: D J Sussman; J Klingensmith; P Salinas; P S Adams; Roel Nusse; Norbert Perrimon
Isolation and characterization of a mouse homolog of the Drosophila segment polarity gene dishevelled.
Developmental biology 1994;166(1):73-86.
1994: J C Hsu; Norbert Perrimon
A temperature-sensitive MEK mutation demonstrates the conservation of the signaling pathways activated by receptor tyrosine kinases.
Genes & development 1994;8(18):2176-87.
1994: E Siegfried; Norbert Perrimon
Drosophila wingless: a paradigm for the function and mechanism of Wnt signaling.
BioEssays : news and reviews in molecular, cellular and developmental biology 1994;16(6):395-404.
1994: Xiangyi Lu; M B Melnick; J C Hsu; Norbert Perrimon
Genetic and molecular analyses of mutations involved in Drosophila raf signal transduction.
The EMBO journal 1994;13(11):2592-9.
1994: Norbert Perrimon
Signalling pathways initiated by receptor protein tyrosine kinases in Drosophila.
Current opinion in cell biology 1994;6(2):260-6.
1994: Norbert Perrimon
The genetic basis of patterned baldness in Drosophila.
Cell 1994;76(5):781-4.
1994: A H Brand; Norbert Perrimon
Raf acts downstream of the EGF receptor to determine dorsoventral polarity during Drosophila oogenesis.
Genes & development 1994;8(5):629-39.
1994: R Binari; Norbert Perrimon
Stripe-specific regulation of pair-rule genes by hopscotch, a putative Jak family tyrosine kinase in Drosophila.
Genes & development 1994;8(3):300-12.
1994: E Siegfried; E L Wilder; Norbert Perrimon
Components of wingless signalling in Drosophila.
Nature 1994;367(6458):76-80.
1994: J Noordermeer; J Klingensmith; Norbert Perrimon; Roel Nusse
dishevelled and armadillo act in the wingless signalling pathway in Drosophila.
Nature 1994;367(6458):80-3.
1994: J Klingensmith; Roel Nusse; Norbert Perrimon
The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal.
Genes & development 1994;8(1):118-30.
1993: M van den Heuvel; C Harryman-Samos; J Klingensmith; Norbert Perrimon; Roel Nusse
Mutations in the segment polarity genes wingless and porcupine impair secretion of the wingless protein.
The EMBO journal 1993;12(13):5293-302.
1993: T B Chou; E Noll; Norbert Perrimon
Autosomal P[ovoD1] dominant female-sterile insertions in Drosophila and their use in generating germ-line chimeras.
Development (Cambridge, England) 1993;119(4):1359-69.
1993: M B Melnick; E Noll; Norbert Perrimon
The Drosophila stubarista phenotype is associated with a dosage effect of the putative ribosome-associated protein D-p40 on spineless.
Genetics 1993;135(2):553-64.
1993: Norbert Perrimon
The torso receptor protein-tyrosine kinase signaling pathway: an endless story.
Cell 1993;74(2):219-22.
1993: D A Harrison; Norbert Perrimon
Simple and efficient generation of marked clones in Drosophila.
Current biology : CB 1993;3(7):424-33.
1993: E Noll; L A Perkins; A P Mahowald; Norbert Perrimon
Approaches to identify genes involved in Drosophila embryonic CNS development.
Journal of neurobiology 1993;24(6):701-22.
1993: A H Brand; Norbert Perrimon
Targeted gene expression as a means of altering cell fates and generating dominant phenotypes.
Development (Cambridge, England) 1993;118(2):401-15.
1993: M B Melnick; L A Perkins; M Lee; L Ambrosio; Norbert Perrimon
Developmental and molecular characterization of mutations in the Drosophila-raf serine/threonine protein kinase.
Development (Cambridge, England) 1993;118(1):127-38.
1993: Xiangyi Lu; T B Chou; N G Williams; T Roberts; Norbert Perrimon
Control of cell fate determination by p21ras/Ras1, an essential component of torso signaling in Drosophila.
Genes & development 1993;7(4):621-32.
1993: Xiangyi Lu; L A Perkins; Norbert Perrimon
The torso pathway in Drosophila: a model system to study receptor tyrosine kinase signal transduction.
Development (Cambridge, England). Supplement 1993;():47-56.
1993: M van den Heuvel; J Klingensmith; Norbert Perrimon; Roel Nusse
Cell patterning in the Drosophila segment: engrailed and wingless antigen distributions in segment polarity mutant embryos.
Development (Cambridge, England). Supplement 1993;():105-14.
1992: E Siegfried; T B Chou; Norbert Perrimon
wingless signaling acts through zeste-white 3, the Drosophila homolog of glycogen synthase kinase-3, to regulate engrailed and establish cell fate.
Cell 1992;71(7):1167-79.
1992: B J Rutledge; K Zhang; E Bier; Y N Jan; Norbert Perrimon
The Drosophila spitz gene encodes a putative EGF-like growth factor involved in dorsal-ventral axis formation and neurogenesis.
Genes & development 1992;6(8):1503-17.
1992: L A Perkins; I Larsen; Norbert Perrimon
corkscrew encodes a putative protein tyrosine phosphatase that functions to transduce the terminal signal from the receptor tyrosine kinase torso.
Cell 1992;70(2):225-36.
1992: T B Chou; Norbert Perrimon
Use of a yeast site-specific recombinase to produce female germline chimeras in Drosophila.
Genetics 1992;131(3):643-53.
1992: Duyen T Dang; Norbert Perrimon
Use of a yeast site-specific recombinase to generate embryonic mosaics in Drosophila.
Developmental genetics 1992;13(5):367-75.
1991: L A Perkins; Norbert Perrimon
The molecular genetics of tail development in Drosophila melanogaster.
In vivo (Athens, Greece) 1991;5(5):521-31.
1991: R Finkelstein; Norbert Perrimon
The molecular genetics of head development in Drosophila melanogaster.
Development (Cambridge, England) 1991;112(4):899-912.
1991: K Zhang; D Smouse; Norbert Perrimon
The crooked neck gene of Drosophila contains a motif found in a family of yeast cell cycle genes.
Genes & development 1991;5(6):1080-91.
1991: Norbert Perrimon; E Noll; Kimberly McCall; A Brand
Generating lineage-specific markers to study Drosophila development.
Developmental genetics 1991;12(3):238-52.
1990: E Siegfried; L Ambrosio; Norbert Perrimon
Serine/threonine protein kinases in Drosophila.
Trends in genetics : TIG 1990;6(11):357-62.
1990: R Finkelstein; D Smouse; T M Capaci; ALLAN SPRADLING; Norbert Perrimon
The orthodenticle gene encodes a novel homeo domain protein involved in the development of the Drosophila nervous system and ocellar visual structures.
Genes & development 1990;4(9):1516-27.
1990: R Finkelstein; Norbert Perrimon
The orthodenticle gene is regulated by bicoid and torso and specifies Drosophila head development.
Nature 1990;346(6283):485-8.
1990: K Zhang; J R Chaillet; L A Perkins; Thanos D Halazonetis; Norbert Perrimon
Drosophila homolog of the mammalian jun oncogene is expressed during embryonic development and activates transcription in mammalian cells.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(16):6281-5.
1990: E Siegfried; L A Perkins; T M Capaci; Norbert Perrimon
Putative protein kinase product of the Drosophila segment-polarity gene zeste-white3.
Nature 1990;345(6278):825-9.
1990: L A Perkins; J S Doctor; K Zhang; L Stinson; Norbert Perrimon; E A Craig
Molecular and developmental characterization of the heat shock cognate 4 gene of Drosophila melanogaster.
Molecular and cellular biology 1990;10(6):3232-8.
1990: D Smouse; Norbert Perrimon
Genetic dissection of a complex neurological mutant, polyhomeotic, in Drosophila.
Developmental biology 1990;139(1):169-85.
1989: L Ambrosio; A P Mahowald; Norbert Perrimon
Requirement of the Drosophila raf homologue for torso function.
Nature 1989;342(6247):288-91.
1989: J Klingensmith; E Noll; Norbert Perrimon
The segment polarity phenotype of Drosophila involves differential tendencies toward transformation and cell death.
Developmental biology 1989;134(1):130-45.
1989: L Ambrosio; A P Mahowald; Norbert Perrimon
l(1)pole hole is required maternally for pattern formation in the terminal regions of the embryo.
Development (Cambridge, England) 1989;106(1):145-58.
1989: Norbert Perrimon; L Engstrom; A P Mahowald
Zygotic lethals with specific maternal effect phenotypes in Drosophila melanogaster. I. Loci on the X chromosome.
Genetics 1989;121(2):333-52.
1989: Norbert Perrimon; D Smouse; G L Miklos
Developmental genetics of loci at the base of the X chromosome of Drosophila melanogaster.
Genetics 1989;121(2):313-31.
1988: Brian Oliver; Norbert Perrimon; A P Mahowald
Genetic evidence that the sans fille locus is involved in Drosophila sex determination.
Genetics 1988;120(1):159-71.
1988: D Smouse; C Goodman; A Mahowald; Norbert Perrimon
polyhomeotic: a gene required for the embryonic development of axon pathways in the central nervous system of Drosophila.
Genes & development 1988;2(7):830-42.
1988: Norbert Perrimon
The maternal effect of lethal(1)discs-large-1: a recessive oncogene of Drosophila melanogaster.
Developmental biology 1988;127(2):392-407.
1987: Brian Oliver; Norbert Perrimon; A P Mahowald
The ovo locus is required for sex-specific germ line maintenance in Drosophila.
Genes & development 1987;1(9):913-23.
1986: Norbert Perrimon; D Mohler; L Engstrom; A P Mahowald
X-linked female-sterile loci in Drosophila melanogaster.
Genetics 1986;113(3):695-712.
1985: Norbert Perrimon; L Engstrom; A P Mahowald
Developmental genetics of the 2C-D region of the Drosophila X chromosome.
Genetics 1985;111(1):23-41.
1985: Norbert Perrimon; L Engstrom; A P Mahowald
A pupal lethal mutation with a paternally influenced maternal effect on embryonic development in Drosophila melanogaster.
Developmental biology 1985;110(2):480-91.
1985: K D Konrad; L Engstrom; Norbert Perrimon; A P Mahowald
Genetic analysis of oogenesis and the role of maternal gene expression in early development.
Developmental biology (New York, N.Y. : 1985) 1985;1():577-617.
1984: Norbert Perrimon; L Engstrom; A P Mahowald
Developmental genetics of the 2E-F region of the Drosophila X chromosome: a region rich in "developmentally important" genes.
Genetics 1984;108(3):559-72.
1984: Norbert Perrimon; L Engstrom; A P Mahowald
The effects of zygotic lethal mutations on female germ-line functions in Drosophila.
Developmental biology 1984;105(2):404-14.