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Deborah Persaud

Research Profile

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CD4-Positive T-Lymphocytes

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Joseph P Casazza; Mary E Enama; Ingelise J Gordon; Emma Gostick; Raphael Gottardo; Barney S Graham; Mary F Kearney; Richard A Koup; Julie E Ledgerwood; Frank M Maldarelli; Martha C Nason; Deborah Persaud; David A Price; Mario Roederer; Emily C Smith; Ann Wiegand; Carrie Ziemniak; Selorm Adzaku; David R Ambrozak; Charla A Andrews; Robert T Bailer; Kathryn A Bowman
Therapeutic Vaccination Expands and Improves the Function of the HIV-Specific Memory T-Cell Repertoire.
Deborah Persaud; Ram Yogev; Carrie Ziemniak; Carmelita G Alvero; Edmund V Capparelli; Michael D Hughes; Katherine Luzuriaga; Paul E Palumbo; Ellen G Chadwick
Dynamics of the resting CD4(+) T-cell latent HIV reservoir in infants initiating HAART less than 6 months of age.
Louise Kuhn; Leigh Martens; Tammy Meyers; Lynn Morris; Deborah Persaud; Gayle Sherman; Renate Strehlau; Wei-Yann Tsai; Ashraf H Coovadia; Chih-Chi Hu; Gillian Hunt; Elaine J Abrams
Switching children previously exposed to nevirapine to nevirapine-based treatment after initial suppression with a protease-inhibitor-based regimen: long-term follow-up of a randomised, open-label trial.

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All Publications

2013: Joseph P Casazza; Mary E Enama; Ingelise J Gordon; Emma Gostick; Raphael Gottardo; Barney S Graham; Mary F Kearney; Richard A Koup; Julie E Ledgerwood; Frank M Maldarelli; Martha C Nason; Deborah Persaud; David A Price; Mario Roederer; Emily C Smith; Ann Wiegand; Carrie Ziemniak; Selorm Adzaku; David R Ambrozak; Charla A Andrews; Robert T Bailer; Kathryn A Bowman
Therapeutic Vaccination Expands and Improves the Function of the HIV-Specific Memory T-Cell Repertoire.
The Journal of infectious diseases 2013;207(12):1829-40.
2012: Deborah Persaud; Ram Yogev; Carrie Ziemniak; Carmelita G Alvero; Edmund V Capparelli; Michael D Hughes; Katherine Luzuriaga; Paul E Palumbo; Ellen G Chadwick
Dynamics of the resting CD4(+) T-cell latent HIV reservoir in infants initiating HAART less than 6 months of age.
AIDS (London, England) 2012;26(12):1483-90.
2012: Louise Kuhn; Leigh Martens; Tammy Meyers; Lynn Morris; Deborah Persaud; Gayle Sherman; Renate Strehlau; Wei-Yann Tsai; Ashraf H Coovadia; Chih-Chi Hu; Gillian Hunt; Elaine J Abrams
Switching children previously exposed to nevirapine to nevirapine-based treatment after initial suppression with a protease-inhibitor-based regimen: long-term follow-up of a randomised, open-label trial.
The Lancet infectious diseases 2012;12(7):521-30.
2012: Silvia Bertagnolio; Michael R Jordan; Lynne M Mofenson; Martina Penazzato; Deborah Persaud; Diane E Bennett
World Health Organization generic protocol to assess drug-resistant HIV among children <18 months of age and newly diagnosed with HIV in resource-limited countries.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2012;54 Suppl 4():S254-60.
2011: Carrie Ziemniak; ANDREA RUFF; Birgitte B Simen; Abubaker Bedri; Ya-Hui Chen; Susan H Eshleman; Leila Khaki; Yohannes Menigstu; Paul Palumbo; Deborah Persaud
Use of dried-blood-spot samples and in-house assays to identify antiretroviral drug resistance in HIV-infected children in resource-constrained settings.
Journal of clinical microbiology 2011;49(12):4077-82.
2011: Deborah Persaud; Carrie Ziemniak; Amanda Blackford; Terry Fenton; Kimberly Ferguson; Thomas Greenough; Katherine Luzuriaga; Petronella Muresan; Natalie Neu; Coleen K Cunningham
Effect of therapeutic HIV recombinant poxvirus vaccines on the size of the resting CD4+ T-cell latent HIV reservoir.
AIDS (London, England) 2011;25(18):2227-34.
2011: Deborah Persaud; Carrie Ziemniak; ANDREA RUFF; AIDA ABASHAWL; RAHEL ADAMU; Roxann Ashworth; Abubaker Bedri; Berhanu Gudetta; ELHAM HASSEN; Abdulhamid Isehak; Solomon Kumbi; Sileshi Lulseged; Yohannes Menigstu; Anitha Moorthy; Saad Omer
Slower clearance of nevirapine resistant virus in infants failing extended nevirapine prophylaxis for prevention of mother-to-child HIV transmission.
AIDS research and human retroviruses 2011;27(8):823-9.
2011: M Tamhane; B Gautney; C Shiu; N Segaren; L Jeannis; C Eustache; Y Simeon-Fadois; Y H Chen; D De; S Irivinti; P Tamma; CAROL THOMPSON; S Khamadi; George K Siberry; Deborah Persaud
Analysis of the optimal cut-point for HIV-p24 antigen testing to diagnose HIV infection in HIV-exposed children from resource-constrained settings.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2011;50(4):338-41.
2011: Anitha Moorthy; Louise Kuhn; Ashraf H Coovadia; Tammy Meyers; Renate Strehlau; Gayle Sherman; Wei-Yann Tsai; Ya Hui Chen; Elaine J Abrams; Deborah Persaud
Induction therapy with protease-inhibitors modifies the effect of nevirapine resistance on virologic response to nevirapine-based HAART in children.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2011;52(4):514-21.
2009: Carlum Shiu; Coleen K Cunningham; Thomas Greenough; Petronella Muresan; Victor Sanchez-Merino; Vincent Carey; J Brooks Jackson; Carrie Ziemniak; Lawrence Fox; Marvin Belzer; Stuart C Ray; Katherine Luzuriaga; Deborah Persaud
Identification of ongoing human immunodeficiency virus type 1 (HIV-1) replication in residual viremia during recombinant HIV-1 poxvirus immunizations in patients with clinically undetectable viral loads on durable suppressive highly active antiretroviral therapy.
Journal of virology 2009;83(19):9731-42.
2009: Anitha Moorthy; Amita Gupta; Ramesh Bhosale; Srikanth Tripathy; Jayagowri Sastry; Smita Kulkarni; Madhuri Thakar; Renu Bharadwaj; Anju Kagal; Arvind V Bhore; Sandesh Patil; Vandana Kulkarni; Varadharajan Venkataramani; Usha Balasubramaniam; Nishi Suryavanshi; Carrie Ziemniak; Nikhil Gupte; Robert Bollinger; Deborah Persaud
Nevirapine resistance and breast-milk HIV transmission: effects of single and extended-dose nevirapine prophylaxis in subtype C HIV-infected infants.
PloS one 2009;4(1):e4096.
2008: Thomas C Greenough; Coleen K Cunningham; Petronella Muresan; Margaret McManus; Deborah Persaud; Terry Fenton; Piers Barker; Aditya Gaur; Dennis Panicali; John L Sullivan; Katherine Luzuriaga
Safety and immunogenicity of recombinant poxvirus HIV-1 vaccines in young adults on highly active antiretroviral therapy.
Vaccine 2008;26(52):6883-93.
2008: Catherine Sutcliffe; Janneke H van Dijk; Carolyn Bolton; Deborah Persaud; William J Moss
Effectiveness of antiretroviral therapy among HIV-infected children in sub-Saharan Africa.
The Lancet infectious diseases 2008;8(8):477-89.
2008: ALLISON AGWU; Jane C Lindsey; Kimberly Ferguson; Haili Zhang; Stephen Spector; Bret J Rudy; Stuart C Ray; Steven D Douglas; Patricia M Flynn; Deborah Persaud
Analyses of HIV-1 drug-resistance profiles among infected adolescents experiencing delayed antiretroviral treatment switch after initial nonsuppressive highly active antiretroviral therapy.
AIDS patient care and STDs 2008;22(7):545-52.
2007: Deborah Persaud; Paul Palumbo; Carrie Ziemniak; Jie Chen; Stuart C Ray; Michael Hughes; Peter Havens; Murli Purswani; Aditya H Gaur; Ellen G Chadwick
Early archiving and predominance of nonnucleoside reverse transcriptase inhibitor-resistant HIV-1 among recently infected infants born in the United States.
The Journal of infectious diseases 2007;195(10):1402-10.
2007: Deborah Persaud; Stuart C Ray; Joleen Kajdas; Aima Ahonkhai; George K Siberry; Kimberly Ferguson; Carrie Ziemniak; Thomas C Quinn; Joseph P Casazza; Steven Zeichner; Stephen J Gange; Douglas C Watson
Slow human immunodeficiency virus type 1 evolution in viral reservoirs in infants treated with effective antiretroviral therapy.
AIDS research and human retroviruses 2007;23(3):381-90.
2006: Carrie Ziemniak; Allison George-Agwu; William J Moss; Stuart C Ray; Deborah Persaud
A sensitive genotyping assay for detection of drug resistance mutations in reverse transcriptase of HIV-1 subtypes B and C in samples stored as dried blood spots or frozen RNA extracts.
Journal of virological methods 2006;136(1-2):238-47.
2006: Justin R Bailey; Ahmad R Sedaghat; Tara L Kieffer; Timothy Brennan; Patricia K Lee; Megan Wind-Rotolo; Christine M Haggerty; Ashrit R Kamireddi; Yi Liu; Jessica Lee; Deborah Persaud; Joel E Gallant; Joseph Cofrancesco; Thomas C Quinn; Claus O Wilke; Stuart C Ray; Janet D Siliciano; Richard E Nettles; Robert Siliciano
Residual human immunodeficiency virus type 1 viremia in some patients on antiretroviral therapy is dominated by a small number of invariant clones rarely found in circulating CD4+ T cells.
Journal of virology 2006;80(13):6441-57.
2006: Deborah Persaud
Latent HIV-1 reservoirs in children: considerations for therapy.
Current opinion in HIV and AIDS 2006;1(2):174-8.
2005: Sanjay K Jain; Deborah Persaud; Trish M Perl; Margaret A Pass; KATHLEEN MURPHY; John Pisciotta; Peter F Scholl; James F Casella; David Sullivan
Nosocomial malaria and saline flush.
Emerging infectious diseases 2005;11(7):1097-9.
2005: Daphne Monie; Rachel P Simmons; Richard E Nettles; Tara L Kieffer; Yan Zhou; Haili Zhang; Sharon Karmon; Roxann G Ingersoll; Karen Chadwick; Hao Zhang; Joseph B Margolick; Thomas C Quinn; Stuart C Ray; Megan Wind-Rotolo; Michael Miller; Deborah Persaud; Robert Siliciano
A novel assay allows genotyping of the latent reservoir for human immunodeficiency virus type 1 in the resting CD4+ T cells of viremic patients.
Journal of virology 2005;79(8):5185-202.
2005: Richard E Nettles; Tara L Kieffer; Patty Kwon; Daphne Monie; Yefei Han; Teresa Parsons; Joseph Cofrancesco; Joel E Gallant; Thomas C Quinn; J Brooks Jackson; Charles Flexner; Kathryn Carson; Stuart C Ray; Deborah Persaud; Robert Siliciano
Intermittent HIV-1 viremia (Blips) and drug resistance in patients receiving HAART.
JAMA : the journal of the American Medical Association 2005;293(7):817-29.
2004: Richard E Nettles; Tara L Kieffer; Rachel P Simmons; Joseph Cofrancesco; Richard D Moore; Joel E Gallant; Deborah Persaud; Robert Siliciano
Genotypic resistance in HIV-1-infected patients with persistently detectable low-level viremia while receiving highly active antiretroviral therapy.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2004;39(7):1030-7.
2004: Tara L Kieffer; Mariel M Finucane; Richard E Nettles; Thomas C Quinn; Karl W Broman; Stuart C Ray; Deborah Persaud; Robert Siliciano
Genotypic analysis of HIV-1 drug resistance at the limit of detection: virus production without evolution in treated adults with undetectable HIV loads.
The Journal of infectious diseases 2004;189(8):1452-65.
2004: Deborah Persaud; Joel E Gallant
Report from San Francisco: The 11th Conference on Retroviruses and Opportunistic Infections (CROI). The tenacity of NNRTI drug resistance.
The Hopkins HIV report : a bimonthly newsletter for healthcare providers / Johns Hopkins University AIDS Service 2004;16(2):1, 5, 15.
2004: Haili Zhang; Yan Zhou; Cecily Alcock; Tara Kiefer; Daphne Monie; Janet D Siliciano; Quan Li; Paul A Pham; Joseph Cofrancesco; Deborah Persaud; Robert Siliciano
Novel single-cell-level phenotypic assay for residual drug susceptibility and reduced replication capacity of drug-resistant human immunodeficiency virus type 1.
Journal of virology 2004;78(4):1718-29.
2004: Deborah Persaud; George K Siberry; Aima Ahonkhai; Joleen Kajdas; Daphne Monie; Nancy Hutton; Douglas C Watson; Thomas C Quinn; Stuart C Ray; Robert Siliciano
Continued production of drug-sensitive human immunodeficiency virus type 1 in children on combination antiretroviral therapy who have undetectable viral loads.
Journal of virology 2004;78(2):968-79.
2003: Deborah Persaud; Yan Zhou; Janet D Siliciano; Robert Siliciano
Latency in human immunodeficiency virus type 1 infection: no easy answers.
Journal of virology 2003;77(3):1659-65.
2002: Christian T Ruff; Stuart C Ray; Patty Kwon; Rebekah Zinn; Amanda R Pendleton; Nancy Hutton; Roxann Ashworth; Stephen J Gange; Thomas C Quinn; Robert Siliciano; Deborah Persaud
Persistence of wild-type virus and lack of temporal structure in the latent reservoir for human immunodeficiency virus type 1 in pediatric patients with extensive antiretroviral exposure.
Journal of virology 2002;76(18):9481-92.
2002: Joel N Blankson; Deborah Persaud; Robert Siliciano
The challenge of viral reservoirs in HIV-1 infection.
Annual review of medicine 2002;53():557-93.
2001: Monika Hermankova; Stuart C Ray; Christian T Ruff; M Powell-Davis; Roxann G Ingersoll; R T D'Aquila; Thomas C Quinn; Janet D Siliciano; Robert Siliciano; Deborah Persaud
HIV-1 drug resistance profiles in children and adults with viral load of <50 copies/ml receiving combination therapy.
JAMA : the journal of the American Medical Association 2001;286(2):196-207.
2000: RAVIT BOGER; Marcela Echavarria; M Forman; PATRICIA CHARACHE; Deborah Persaud
Clearance of adenoviral hepatitis with ribavirin therapy in a pediatric liver transplant recipient.
The Pediatric infectious disease journal 2000;19(11):1097-100.
2000: Deborah Persaud; Theodore C Pierson; Christian T Ruff; Diana Finzi; Karen Chadwick; Joseph B Margolick; ANDREA RUFF; Nancy Hutton; Stuart C Ray; Robert Siliciano
A stable latent reservoir for HIV-1 in resting CD4(+) T lymphocytes in infected children.
The Journal of clinical investigation 2000;105(7):995-1003.
1999: Joel N Blankson; Deborah Persaud; Robert Siliciano
Latent reservoirs for HIV-1.
Current opinion in infectious diseases 1999;12(1):5-11.
1998: S L Tarsis; MT Yu; E S Parks; Deborah Persaud; J L Muñoz; Wade P Parks
Human T-lymphocyte transformation with human T-cell lymphotropic virus type 2.
Journal of virology 1998;72(1):841-6.
1995: Deborah Persaud; J L Muñoz; S L Tarsis; E S Parks; Wade P Parks
Time course and cytokine dependence of human T-cell lymphotropic virus type 1 T-lymphocyte transformation as revealed by a microtiter infectivity assay.
Journal of virology 1995;69(10):6297-303.
1995: E Leibovitz; Henry Pollack; M Rigaud; A Kaul; Deborah Persaud; L Gallo; J Papellas; Keith Krasinski; William Borkowsky
Polymerase chain reaction is more sensitive than standard cytologic stains in detecting Pneumocystis carinii in bronchoalveolar lavages from human immunodeficiency virus type 1-infected infants and children with pneumonia.
The Pediatric infectious disease journal 1995;14(8):714-6.
1994: M Rigaud; Henry Pollack; E Leibovitz; Mimi Y Kim; Deborah Persaud; A Kaul; R Lawrence; D D John; William Borkowsky; Keith Krasinski
Efficacy of primary chemoprophylaxis against Pneumocystis carinii pneumonia during the first year of life in infants infected with human immunodeficiency virus type 1.
The Journal of pediatrics 1994;125(3):476-80.
1993: Deborah Persaud; William J Moss; J L Muñoz
Serious eye infections in children.
Pediatric annals 1993;22(6):379-83; quiz 384-5.
1993: Deborah Persaud; B Bangaru; M Alba Greco; S Nachman; Khush Mittal; S Chandwani; Keith Krasinski; William Borkowsky; A Kaul
Cholestatic hepatitis in children infected with the human immunodeficiency virus.
The Pediatric infectious disease journal 1993;12(6):492-8.
1992: J E Aronson; George McSherry; L Hoyt; M Boland; James M Oleske; Edward M Connor; Deborah Persaud; W Borkowsky; K Krasinski; SS Bakshi
Varicella does not appear to be a cofactor for human immunodeficiency virus infection in children.
The Pediatric infectious disease journal 1992;11(12):1004-8.
1992: Deborah Persaud; S Chandwani; M Rigaud; E Leibovitz; A Kaul; R Lawrence; Henry Pollack; D DiJohn; Keith Krasinski; William Borkowsky
Delayed recognition of human immunodeficiency virus infection in preadolescent children.
Pediatrics 1992;90(5):688-91.