Roger Pertwee

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Chemicals & Drugs

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Appendino Giovanni; Ligresti Alessia; Minassi Alberto; Cascio Maria Grazia; Allarà Marco; Taglialatela-Scafati Orazio; Pertwee Roger G; De Petrocellis Luciano; Di Marzo Vincenzo
Conformationally constrained fatty acid ethanolamides as cannabinoid and vanilloid receptor probes.
Riedel Gernot; Fadda Paola; McKillop-Smith Susan; Pertwee Roger G; Platt Bettina; Robinson Lianne
Synthetic and plant-derived cannabinoid receptor antagonists show hypophagic properties in fasted and non-fasted mice.
Ryan Duncan; Drysdale Alison J; Lafourcade Carlos; Pertwee Roger G; Platt Bettina
Cannabidiol targets mitochondria to regulate intracellular Ca2+ levels.

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All Publications

2009: Appendino Giovanni; Ligresti Alessia; Minassi Alberto; Cascio Maria Grazia; Allarà Marco; Taglialatela-Scafati Orazio; Pertwee Roger G; De Petrocellis Luciano; Di Marzo Vincenzo
Conformationally constrained fatty acid ethanolamides as cannabinoid and vanilloid receptor probes.
Journal of medicinal chemistry 2009;52(9):3001-9.
2009: Riedel Gernot; Fadda Paola; McKillop-Smith Susan; Pertwee Roger G; Platt Bettina; Robinson Lianne
Synthetic and plant-derived cannabinoid receptor antagonists show hypophagic properties in fasted and non-fasted mice.
British journal of pharmacology 2009;156(7):1154-66.
2009: Ryan Duncan; Drysdale Alison J; Lafourcade Carlos; Pertwee Roger G; Platt Bettina
Cannabidiol targets mitochondria to regulate intracellular Ca2+ levels.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(7):2053-63.
2009: Pertwee Roger G
Emerging strategies for exploiting cannabinoid receptor agonists as medicines.
British journal of pharmacology 2009;156(3):397-411.
2008: Alvarez Francisco J; Lafuente Hector; Rey-Santano M Carmen; Mielgo Victoria E; Gastiasoro Elena; Rueda Miguel; Pertwee Roger G; Castillo Ana I; Romero Julián; Martínez-Orgado José
Neuroprotective effects of the nonpsychoactive cannabinoid cannabidiol in hypoxic-ischemic newborn piglets.
Pediatric research 2008;64(6):653-8.
2008: Robinson Lianne; McKillop-Smith Susan; Ross Nicola L; Pertwee Roger G; Hampson Robert E; Platt Bettina; Riedel Gernot
Hippocampal endocannabinoids inhibit spatial learning and limit spatial memory in rats.
Psychopharmacology 2008;198(4):551-63.
2008: Pertwee Roger G
Ligands that target cannabinoid receptors in the brain: from THC to anandamide and beyond.
Addiction biology 2008;13(2):147-59.
2008: McHugh Douglas; Tanner Carolyn; Mechoulam Raphael; Pertwee Roger G; Ross Ruth A
Inhibition of human neutrophil chemotaxis by endogenous cannabinoids and phytocannabinoids: evidence for a site distinct from CB1 and CB2.
Molecular pharmacology 2008;73(2):441-50.
2008: Croxford J Ludovic; Pryce Gareth; Jackson Samuel J; Ledent Catherine; Giovannoni Gavin; Pertwee Roger G; Yamamura Takashi; Baker David
Cannabinoid-mediated neuroprotection, not immunosuppression, may be more relevant to multiple sclerosis.
Journal of neuroimmunology 2008;193(1-2):120-9.
2008: Pertwee R G
The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin.
British journal of pharmacology 2008;153(2):199-215.
2007: Pertwee R G
GPR55: a new member of the cannabinoid receptor clan?
British journal of pharmacology 2007;152(7):984-6.
2007: Xu Heping; Cheng Ching L; Chen Mei; Manivannan Ayyakkannu; Cabay Laurence; Pertwee Roger G; Coutts Angela; Forrester John V
Anti-inflammatory property of the cannabinoid receptor-2-selective agonist JWH-133 in a rodent model of autoimmune uveoretinitis.
Journal of leukocyte biology 2007;82(3):532-41.
2007: Pertwee Roger G
Cannabinoids and multiple sclerosis.
Molecular neurobiology 2007;36(1):45-59.
2007: Robinson L; Goonawardena A V; Pertwee R G; Hampson R E; Riedel G
The synthetic cannabinoid HU210 induces spatial memory deficits and suppresses hippocampal firing rate in rats.
British journal of pharmacology 2007;151(5):688-700.
2007: Ryan Duncan; Drysdale Alison J; Pertwee Roger G; Platt Bettina
Interactions of cannabidiol with endocannabinoid signalling in hippocampal tissue.
The European journal of neuroscience 2007;25(7):2093-102.
2007: Maresz Katarzyna; Pryce Gareth; Ponomarev Eugene D; Marsicano Giovanni; Croxford J Ludovic; Shriver Leah P; Ledent Catherine; Cheng Xiaodong; Carrier Erica J; Mann Monica K; Giovannoni Gavin; Pertwee Roger G; Yamamura Takashi; Buckley Nancy E; Hillard Cecilia J; Lutz Beat; Baker David; Dittel Bonnie N
Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cells.
Nature medicine 2007;13(4):492-7.
2007: Pertwee R G; Thomas A; Stevenson L A; Ross R A; Varvel S A; Lichtman A H; Martin B R; Razdan R K
The psychoactive plant cannabinoid, Delta9-tetrahydrocannabinol, is antagonized by Delta8- and Delta9-tetrahydrocannabivarin in mice in vivo.
British journal of pharmacology 2007;150(5):586-94.
2007: Thomas A; Baillie G L; Phillips A M; Razdan R K; Ross R A; Pertwee R G
Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro.
British journal of pharmacology 2007;150(5):613-23.
2006: Ryan Duncan; Drysdale Alison J; Pertwee Roger G; Platt Bettina
Differential effects of cannabis extracts and pure plant cannabinoids on hippocampal neurones and glia.
Neuroscience letters 2006;408(3):236-41.
2006: Tomida Ileana; Azuara-Blanco Augusto; House Heather; Flint Maggie; Pertwee Roger G; Robson Philip J
Effect of sublingual application of cannabinoids on intraocular pressure: a pilot study.
Journal of glaucoma 2006;15(5):349-53.
2006: Pertwee R G
The pharmacology of cannabinoid receptors and their ligands: an overview.
International journal of obesity (2005) 2006;30 Suppl 1():S13-8.
2006: Fadda Paola; Robinson Lianne; Fratta Walter; Pertwee Roger G; Riedel Gernot
Scopolamine and MK801-induced working memory deficits in rats are not reversed by CBD-rich cannabis extracts.
Behavioural brain research 2006;168(2):307-11.
2006: Drysdale Alison J; Ryan Duncan; Pertwee Roger G; Platt Bettina
Cannabidiol-induced intracellular Ca2+ elevations in hippocampal cells.
Neuropharmacology 2006;50(5):621-31.
2006: McHugh Douglas; McMaster R Shannon; Pertwee Roger G; Roy Sucharita; Mahadevan Anu; Razdan Raj K; Ross Ruth A
Novel compounds that interact with both leukotriene B4 receptors and vanilloid TRPV1 receptors.
The Journal of pharmacology and experimental therapeutics 2006;316(2):955-65.
2006: Pertwee Roger G
Cannabinoid pharmacology: the first 66 years.
British journal of pharmacology 2006;147 Suppl 1():S163-71.
2006: Thomas Adèle; Pertwee Roger G
The bioassay of cannabinoids using the mouse isolated vas deferens.
Methods in molecular medicine 2006;123():191-207.
2005: Thomas Adèle; Stevenson Lesley A; Wease Kerrie N; Price Martin R; Baillie Gemma; Ross Ruth A; Pertwee Roger G
Evidence that the plant cannabinoid Delta9-tetrahydrocannabivarin is a cannabinoid CB1 and CB2 receptor antagonist.
British journal of pharmacology 2005;146(7):917-26.
2005: Vandevoorde Séverine; Saha Bijali; Mahadevan Anu; Razdan Raj K; Pertwee Roger G; Martin Billy R; Fowler Christopher J
Influence of the degree of unsaturation of the acyl side chain upon the interaction of analogues of 1-arachidonoylglycerol with monoacylglycerol lipase and fatty acid amide hydrolase.
Biochemical and biophysical research communications 2005;337(1):104-9.
2005: Price Martin R; Baillie Gemma L; Thomas Adèle; Stevenson Lesley A; Easson Morag; Goodwin Richard; McLean Adèle; McIntosh Lorraine; Goodwin Gillian; Walker Glenn; Westwood Paul; Marrs Julia; Thomson Fiona; Cowley Phillip; Christopoulos Arthur; Pertwee Roger G; Ross Ruth A
Allosteric modulation of the cannabinoid CB1 receptor.
Molecular pharmacology 2005;68(5):1484-95.
2005: Thomas Brian F; Francisco Maria Elena Y; Seltzman Herbert H; Thomas James B; Fix Scott E; Schulz Anne-Kathrin; Gilliam Anne F; Pertwee Roger G; Stevenson Leslie A
Synthesis of long-chain amide analogs of the cannabinoid CB1 receptor antagonist N-(piperidinyl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716) with unique binding selectivities and pharmacological activities.
Bioorganic & medicinal chemistry 2005;13(18):5463-74.
2005: Pertwee Roger G; Thomas Adèle; Stevenson Lesley A; Maor Yehoshua; Mechoulam Raphael
Evidence that (-)-7-hydroxy-4'-dimethylheptyl-cannabidiol activates a non-CB(1), non-CB(2), non-TRPV1 target in the mouse vas deferens.
Neuropharmacology 2005;48(8):1139-46.
2005: Pertwee Roger G
Inverse agonism and neutral antagonism at cannabinoid CB1 receptors.
Life sciences 2005;76(12):1307-24.
2005: Pertwee R G
Pharmacological actions of cannabinoids.
Handbook of experimental pharmacology 2005;(168):1-51.
2005: Pertwee Roger G
The therapeutic potential of drugs that target cannabinoid receptors or modulate the tissue levels or actions of endocannabinoids.
The AAPS journal 2005;7(3):E625-54.
2004: Fadda Paola; Robinson Lianne; Fratta Walter; Pertwee Roger G; Riedel Gernot
Differential effects of THC- or CBD-rich cannabis extracts on working memory in rats.
Neuropharmacology 2004;47(8):1170-9.
2004: Ghafouri Nazdar; Tiger Gunnar; Razdan Raj K; Mahadevan Anu; Pertwee Roger G; Martin Billy R; Fowler Christopher J
Inhibition of monoacylglycerol lipase and fatty acid amide hydrolase by analogues of 2-arachidonoylglycerol.
British journal of pharmacology 2004;143(6):774-84.
2004: Tomida I; Pertwee R G; Azuara-Blanco A
Cannabinoids and glaucoma.
The British journal of ophthalmology 2004;88(5):708-13.
2004: Thomas Adèle; Ross Ruth A; Saha Bijali; Mahadevan Anu; Razdan Raj K; Pertwee Roger G
6"-Azidohex-2"-yne-cannabidiol: a potential neutral, competitive cannabinoid CB1 receptor antagonist.
European journal of pharmacology 2004;487(1-3):213-21.
2003: Papahatjis Demetris P; Nikas Spyros P; Kourouli Therapia; Chari Ravi; Xu Wei; Pertwee Roger G; Makriyannis Alexandros
Pharmacophoric requirements for the cannabinoid side chain. Probing the cannabinoid receptor subsite at C1'.
Journal of medicinal chemistry 2003;46(15):3221-9.
2003: Robinson Lianne; Hinder Lucy; Pertwee Roger G; Riedel Gernot
Effects of delta9-THC and WIN-55,212-2 on place preference in the water maze in rats.
Psychopharmacology 2003;166(1):40-50.
2002: Pertwee Roger G; Ross Ruth A; Craib Susan J; Thomas Adèle
(-)-Cannabidiol antagonizes cannabinoid receptor agonists and noradrenaline in the mouse vas deferens.
European journal of pharmacology 2002;456(1-3):99-106.
2002: Pertwee Roger G
Cannabinoids and multiple sclerosis.
Pharmacology & therapeutics 2002;95(2):165-74.
2002: Coutts Angela A; Irving Andrew J; Mackie Ken; Pertwee Roger G; Anavi-Goffer Sharon
Localisation of cannabinoid CB(1) receptor immunoreactivity in the guinea pig and rat myenteric plexus.
The Journal of comparative neurology 2002;448(4):410-22.
2002: Davies S N; Pertwee R G; Riedel G
Functions of cannabinoid receptors in the hippocampus.
Neuropharmacology 2002;42(8):993-1007.
2002: Francisco Maria Elena Y; Seltzman Herbert H; Gilliam Anne F; Mitchell René A; Rider Sharyl L; Pertwee Roger G; Stevenson Lesley A; Thomas Brian F
Synthesis and structure-activity relationships of amide and hydrazide analogues of the cannabinoid CB(1) receptor antagonist N-(piperidinyl)- 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716).
Journal of medicinal chemistry 2002;45(13):2708-19.
2002: Ross Ruth A; Craib Susan J; Stevenson Lesley A; Pertwee Roger G; Henderson Andrea; Toole John; Ellington Heather C
Pharmacological characterization of the anandamide cyclooxygenase metabolite: prostaglandin E2 ethanolamide.
The Journal of pharmacology and experimental therapeutics 2002;301(3):900-7.
2002: Pertwee R G; Ross R A
Cannabinoid receptors and their ligands.
Prostaglandins, leukotrienes, and essential fatty acids 2002;66(2-3):101-21.
2001: Al-Hayani A; Wease K N; Ross R A; Pertwee R G; Davies S N
The endogenous cannabinoid anandamide activates vanilloid receptors in the rat hippocampal slice.
Neuropharmacology 2001;41(8):1000-5.
2001: Craib S J; Ellington H C; Pertwee R G; Ross R A
A possible role of lipoxygenase in the activation of vanilloid receptors by anandamide in the guinea-pig bronchus.
British journal of pharmacology 2001;134(1):30-7.
2001: Pertwee R G
Cannabinoids and the gastrointestinal tract.
Gut 2001;48(6):859-67.
2001: Coutts A A; Anavi-Goffer S; Ross R A; MacEwan D J; Mackie K; Pertwee R G; Irving A J
Agonist-induced internalization and trafficking of cannabinoid CB1 receptors in hippocampal neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(7):2425-33.
2001: Pertwee R G
Cannabinoid receptors and pain.
Progress in neurobiology 2001;63(5):569-611.
2001: Ross R A; Gibson T M; Brockie H C; Leslie M; Pashmi G; Craib S J; Di Marzo V; Pertwee R G
Structure-activity relationship for the endogenous cannabinoid, anandamide, and certain of its analogues at vanilloid receptors in transfected cells and vas deferens.
British journal of pharmacology 2001;132(3):631-40.
2001: Baker D; Pryce G; Croxford J L; Brown P; Pertwee R G; Makriyannis A; Khanolkar A; Layward L; Fezza F; Bisogno T; Di Marzo V
Endocannabinoids control spasticity in a multiple sclerosis model.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(2):300-2.
2001: Ross R A; Coutts A A; McFarlane S M; Anavi-Goffer S; Irving A J; Pertwee R G; MacEwan D J; Scott R H
Actions of cannabinoid receptor ligands on rat cultured sensory neurones: implications for antinociception.
Neuropharmacology 2001;40(2):221-32.
2000: Ross R A; Brockie H C; Pertwee R G
Inhibition of nitric oxide production in RAW264.7 macrophages by cannabinoids and palmitoylethanolamide.
European journal of pharmacology 2000;401(2):121-30.
2000: Pertwee R G
Cannabinoid receptor ligands: clinical and neuropharmacological considerations, relevant to future drug discovery and development.
Expert opinion on investigational drugs 2000;9(7):1553-71.
2000: Pertwee R G; Gibson T M; Stevenson L A; Ross R A; Banner W K; Saha B; Razdan R K; Martin B R
O-1057, a potent water-soluble cannabinoid receptor agonist with antinociceptive properties.
British journal of pharmacology 2000;129(8):1577-84.
2000: Baker D; Pryce G; Croxford J L; Brown P; Pertwee R G; Huffman J W; Layward L
Cannabinoids control spasticity and tremor in a multiple sclerosis model.
Nature 2000;404(6773):84-7.
2000: Coutts A A; Brewster N; Ingram T; Razdan R K; Pertwee R G
Comparison of novel cannabinoid partial agonists and SR141716A in the guinea-pig small intestine.
British journal of pharmacology 2000;129(4):645-52.
2000: Irving A J; Coutts A A; Harvey J; Rae M G; Mackie K; Bewick G S; Pertwee R G
Functional expression of cell surface cannabinoid CB(1) receptors on presynaptic inhibitory terminals in cultured rat hippocampal neurons.
Neuroscience 2000;98(2):253-62.
1999: Ross R A; Gibson T M; Stevenson L A; Saha B; Crocker P; Razdan R K; Pertwee R G
Structural determinants of the partial agonist-inverse agonist properties of 6'-azidohex-2'-yne-delta8-tetrahydrocannabinol at cannabinoid receptors.
British journal of pharmacology 1999;128(3):735-43.
1999: Pertwee R G
Pharmacology of cannabinoid receptor ligands.
Current medicinal chemistry 1999;6(8):635-64.
1999: Hillard C J; Manna S; Greenberg M J; DiCamelli R; Ross R A; Stevenson L A; Murphy V; Pertwee R G; Campbell W B
Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1).
The Journal of pharmacology and experimental therapeutics 1999;289(3):1427-33.
1999: Ross R A; Brockie H C; Stevenson L A; Murphy V L; Templeton F; Makriyannis A; Pertwee R G
Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656, and AM630.
British journal of pharmacology 1999;126(3):665-72.
1999: Pertwee R G
Evidence for the presence of CB1 cannabinoid receptors on peripheral neurones and for the existence of neuronal non-CB1 cannabinoid receptors.
Life sciences 1999;65(6-7):597-605.
1998: Reggio P H; Basu-Dutt S; Barnett-Norris J; Castro M T; Hurst D P; Seltzman H H; Roche M J; Gilliam A F; Thomas B F; Stevenson L A; Pertwee R G; Abood M E
The bioactive conformation of aminoalkylindoles at the cannabinoid CB1 and CB2 receptors: insights gained from (E)- and (Z)-naphthylidene indenes.
Journal of medicinal chemistry 1998;41(26):5177-87.
1998: Ross R A; Brockie H C; Fernando S R; Saha B; Razdan R K; Pertwee R G
Comparison of cannabinoid binding sites in guinea-pig forebrain and small intestine.
British journal of pharmacology 1998;125(6):1345-51.
1998: Paton G S; Pertwee R G; Davies S N
Correlation between cannabinoid mediated effects on paired pulse depression and induction of long term potentiation in the rat hippocampal slice.
Neuropharmacology 1998;37(9):1123-30.
1998: Pertwee R G
Pharmacological, physiological and clinical implications of the discovery of cannabinoid receptors.
Biochemical Society transactions 1998;26(2):267-72.
1998: Coutts A A; Pertwee R G
Evidence that cannabinoid-induced inhibition of electrically evoked contractions of the myenteric plexus--longitudinal muscle preparation of guinea-pig small intestine can be modulated by Ca2+ and cAMP.
Canadian journal of physiology and pharmacology 1998;76(3):340-6.
1997: Griffin G; Fernando S R; Ross R A; McKay N G; Ashford M L; Shire D; Huffman J W; Yu S; Lainton J A; Pertwee R G
Evidence for the presence of CB2-like cannabinoid receptors on peripheral nerve terminals.
European journal of pharmacology 1997;339(1):53-61.
1997: Coull M A; Johnston A T; Pertwee R G; Davies S N
Action of delta-9-tetrahydrocannabinol on GABA(A) receptor-mediated responses in a grease-gap recording preparation of the rat hippocampal slice.
Neuropharmacology 1997;36(10):1387-92.
1997: Seltzman H H; Fleming D N; Thomas B F; Gilliam A F; McCallion D S; Pertwee R G; Compton D R; Martin B R
Synthesis and pharmacological comparison of dimethylheptyl and pentyl analogs of anandamide.
Journal of medicinal chemistry 1997;40(22):3626-34.
1997: Reggio P H; Wang T; Brown A E; Fleming D N; Seltzman H H; Griffin G; Pertwee R G; Compton D R; Abood M E; Martin B R
Importance of the C-1 substituent in classical cannabinoids to CB2 receptor selectivity: synthesis and characterization of a series of O,2-propano-delta 8-tetrahydrocannabinol analogs.
Journal of medicinal chemistry 1997;40(20):3312-8.
1997: López-Redondo F; Lees G M; Pertwee R G
Effects of cannabinoid receptor ligands on electrophysiological properties of myenteric neurones of the guinea-pig ileum.
British journal of pharmacology 1997;122(2):330-4.
1997: Fernando S R; Pertwee R G
Evidence that methyl arachidonyl fluorophosphonate is an irreversible cannabinoid receptor antagonist.
British journal of pharmacology 1997;121(8):1716-20.
1997: Coutts A A; Pertwee R G
Inhibition by cannabinoid receptor agonists of acetylcholine release from the guinea-pig myenteric plexus.
British journal of pharmacology 1997;121(8):1557-66.
1997: Pertwee R G
Pharmacology of cannabinoid CB1 and CB2 receptors.
Pharmacology & therapeutics 1997;74(2):129-80.
1996: Pertwee R G; Fernando S R; Griffin G; Ryan W; Razdan R K; Compton D R; Martin B R
Agonist-antagonist characterization of 6'-cyanohex-2'-yne-delta 8-tetrahydrocannabinol in two isolated tissue preparations.
European journal of pharmacology 1996;315(2):195-201.
1996: Pertwee R G; Fernando S R; Nash J E; Coutts A A
Further evidence for the presence of cannabinoid CB1 receptors in guinea-pig small intestine.
British journal of pharmacology 1996;118(8):2199-205.
1996: Pertwee R G; Fernando S R
Evidence for the presence of cannabinoid CB1 receptors in mouse urinary bladder.
British journal of pharmacology 1996;118(8):2053-8.
1996: Pertwee R G; Joe-Adigwe G; Hawksworth G M
Further evidence for the presence of cannabinoid CB1 receptors in mouse vas deferens.
European journal of pharmacology 1996;296(2):169-72.
1995: Pertwee R G; Griffin G; Lainton J A; Huffman J W
Pharmacological characterization of three novel cannabinoid receptor agonists in the mouse isolated vas deferens.
European journal of pharmacology 1995;284(3):241-7.
1995: Wickens A P; Pertwee R G
Effect of delta 9-tetrahydrocannabinol on circling in rats induced by intranigral muscimol administration.
European journal of pharmacology 1995;282(1-3):251-4.
1995: Collins D R; Pertwee R G; Davies S N
Prevention by the cannabinoid antagonist, SR141716A, of cannabinoid-mediated blockade of long-term potentiation in the rat hippocampal slice.
British journal of pharmacology 1995;115(6):869-70.
1995: Pertwee R G; Fernando S R; Griffin G; Abadji V; Makriyannis A
Effect of phenylmethylsulphonyl fluoride on the potency of anandamide as an inhibitor of electrically evoked contractions in two isolated tissue preparations.
European journal of pharmacology 1995;272(1):73-8.
1995: Pertwee R G; Griffin G
A preliminary investigation of the mechanisms underlying cannabinoid tolerance in the mouse vas deferens.
European journal of pharmacology 1995;272(1):67-72.
1995: Reggio P H; Bramblett R D; Yuknavich H; Seltzman H H; Fleming D N; Fernando S R; Stevenson L A; Pertwee R G
The design, synthesis and testing of desoxy-CBD: further evidence for a region of steric interference at the cannabinoid receptor.
Life sciences 1995;56(23-24):2025-32.
1995: Pertwee R; Griffin G; Fernando S; Li X; Hill A; Makriyannis A
AM630, a competitive cannabinoid receptor antagonist.
Life sciences 1995;56(23-24):1949-55.
1994: Collins D R; Pertwee R G; Davies S N
The action of synthetic cannabinoids on the induction of long-term potentiation in the rat hippocampal slice.
European journal of pharmacology 1994;259(3):R7-8.
1994: Pertwee R; Griffin G; Hanus L; Mechoulam R
Effects of two endogenous fatty acid ethanolamides on mouse vasa deferentia.
European journal of pharmacology 1994;259(2):115-20.
1994: Abadji V; Lin S; Taha G; Griffin G; Stevenson L A; Pertwee R G; Makriyannis A
(R)-methanandamide: a chiral novel anandamide possessing higher potency and metabolic stability.
Journal of medicinal chemistry 1994;37(12):1889-93.
1993: Pertwee R G; Stevenson L A; Griffin G
Cross-tolerance between delta-9-tetrahydrocannabinol and the cannabimimetic agents, CP 55,940, WIN 55,212-2 and anandamide.
British journal of pharmacology 1993;110(4):1483-90.
1993: Wickens A P; Pertwee R G
delta 9-Tetrahydrocannabinol and anandamide enhance the ability of muscimol to induce catalepsy in the globus pallidus of rats.
European journal of pharmacology 1993;250(1):205-8.
1993: Pertwee R
The evidence for the existence of cannabinoid receptors.
General pharmacology 1993;24(4):811-24.
1992: Devane W A; Hanus L; Breuer A; Pertwee R G; Stevenson L A; Griffin G; Gibson D; Mandelbaum A; Etinger A; Mechoulam R
Isolation and structure of a brain constituent that binds to the cannabinoid receptor.
Science (New York, N.Y.) 1992;258(5090):1946-9.
1992: Pertwee R G; Stevenson L A; Elrick D B; Mechoulam R; Corbett A D
Inhibitory effects of certain enantiomeric cannabinoids in the mouse vas deferens and the myenteric plexus preparation of guinea-pig small intestine.
British journal of pharmacology 1992;105(4):980-4.
1991: Pertwee R G; Browne S E; Ross T M; Stretton C D
An investigation of the involvement of GABA in certain pharmacological effects of delta-9-tetrahydrocannabinol.
Pharmacology, biochemistry, and behavior 1991;40(3):581-5.
1991: Pertwee R G; Nash K; Trayhurn P
Evidence that the hypothermic response of mice to delta-9-tetrahydrocannabinol is not mediated by changes in thermogenesis in brown adipose tissue.
Canadian journal of physiology and pharmacology 1991;69(6):767-70.
1991: Pertwee R G; Wickens A P
Enhancement by chlordiazepoxide of catalepsy induced in rats by intravenous or intrapallidal injections of enantiomeric cannabinoids.
Neuropharmacology 1991;30(3):237-44.
1991: Pertwee R G; Ross T M
Drugs which stimulate or facilitate central cholinergic transmission interact synergistically with delta-9-tetrahydrocannabinol to produce marked catalepsy in mice.
Neuropharmacology 1991;30(1):67-71.
1988: Pertwee R G; Greentree S G; Swift P A
Drugs which stimulate or facilitate central GABAergic transmission interact synergistically with delta-9-tetrahydrocannabinol to produce marked catalepsy in mice.
Neuropharmacology 1988;27(12):1265-70.
1988: Pertwee R G; Greentree S G
Delta-9-tetrahydrocannabinol-induced catalepsy in mice is enhanced by pretreatment with flurazepam or chlordiazepoxide.
Neuropharmacology 1988;27(5):485-91.
1988: Pertwee R G; Hedley D; McQueen A S; Gentleman S M
The hypothermic response of mice to delta-9-tetrahydrocannabinol is enhanced by chlorpromazine, thioxanthenes, alpha-adrenoceptor antagonists and pentolinium but not by SCH 23390 or sulpiride.
Neuropharmacology 1988;27(2):149-55.
1988: Pertwee R G
The central neuropharmacology of psychotropic cannabinoids.
Pharmacology & therapeutics 1988;36(2-3):189-261.
1987: Gray G A; Hedley D; Pertwee R G
Enhancement of the hypothermic response of mice to delta-9-tetrahydrocannabinol by subhypothermic doses of chlorpromazine and phentolamine.
Neuropharmacology 1987;26(2-3):229-35.

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