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Marcus Peter
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Research Profile (preview)
Chemicals & Drugs
Physiology
Anatomy
Living Beings
Genes & Molecular Sequences
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Network (preview)
34
Krammer, Peter
19
Scaffidi, C
15
Barnhart, Bryan
10
Park, Sun-Mi
8
Algeciras-Schimnich, Alicia
8
Kischkel, FC
7
Feig, Christine
6
Lee, Justine
6
Medema, JP
6
Schickel, Robert
6
Stegh, Alexander
6
Legembre, Patrick
5
Schickling, Olaf
5
Murmann, Andrea
5
Debatin, Klaus-Michael
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Publications
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All Publications
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2009: Peter Marcus E
Let-7 and miR-200 microRNAs: guardians against pluripotency and cancer progression.
Cell cycle (Georgetown, Tex.) 2009;8(6):843-52.
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2008: Schickel R; Boyerinas B; Park S-M; Peter M E
MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death.
Oncogene 2008;27(45):5959-74.
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2008: Peter Marcus E
ROS eliminate danger.
Immunity 2008;29(1):1-2.
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2008: Park Sun-Mi; Peter Marcus E
microRNAs and death receptors.
Cytokine & growth factor reviews 2008;19(3-4):303-11.
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2008: Boyerinas Benjamin; Park Sun-Mi; Shomron Noam; Hedegaard Mads M; Vinther Jeppe; Andersen Jens S; Feig Christine; Xu Jinbo; Burge Christopher B; Peter Marcus E
Identification of let-7-regulated oncofetal genes.
Cancer research 2008;68(8):2587-91.
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2008: Park Sun-Mi; Gaur Arti B; Lengyel Ernst; Peter Marcus E
The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2.
Genes & development 2008;22(7):894-907.
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2008: Sawada Kenjiro; Mitra Anirban K; Radjabi A Reza; Bhaskar Vinay; Kistner Emily O; Tretiakova Maria; Jagadeeswaran Sujatha; Montag Anthony; Becker Amy; Kenny Hilary A; Peter Marcus E; Ramakrishnan Vanitha; Yamada S Diane; Lengyel Ernst
Loss of E-cadherin promotes ovarian cancer metastasis via alpha 5-integrin, which is a therapeutic target.
Cancer research 2008;68(7):2329-39.
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2008: Park Sun-Mi; Rajapaksha Tharinda W; Zhang Manling; Sattar Husain A; Fichera Alessandro; Ashton-Rickardt Philip G; Peter Marcus E
CD95 signaling deficient mice with a wild-type hematopoietic system are prone to hepatic neoplasia.
Apoptosis : an international journal on programmed cell death 2008;13(1):41-51.
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2007: Feig Christine; Peter Marcus E
How apoptosis got the immune system in shape.
European journal of immunology 2007;37 Suppl 1():S61-70.
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2007: Park Sun-Mi; Shell Scott; Radjabi Amir Reza; Schickel Robert; Feig Christine; Boyerinas Ben; Dinulescu Daniela M; Lengyel Ernst; Peter Marcus E
Let-7 prevents early cancer progression by suppressing expression of the embryonic gene HMGA2.
Cell cycle (Georgetown, Tex.) 2007;6(21):2585-90.
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2007: Zhang Manling; Liu Ni; Park Sun-Mi; Wang Yue; Byrne Susan; Murmann Andrea E; Bahr Scott; Peter Marcus E; Olson Steven T; Belaaouaj Abderrazzaq; Ashton-Rickardt Philip G
Serine protease inhibitor 6-deficient mice have increased neutrophil immunity to Pseudomonas aeruginosa.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(7):4390-6.
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2007: Shell Scott; Park Sun-Mi; Radjabi Amir Reza; Schickel Robert; Kistner Emily O; Jewell David A; Feig Christine; Lengyel Ernst; Peter Marcus E
Let-7 expression defines two differentiation stages of cancer.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(27):11400-5.
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2007: Peter Marcus E; Budd Ralph C; Desbarats Julie; Hedrick Stephen M; Hueber Anne-Odile; Newell M Karen; Owen Laurie B; Pope Richard M; Tschopp Juerg; Wajant Harald; Wallach David; Wiltrout Robert H; Zörnig Martin; Lynch David H
The CD95 receptor: apoptosis revisited.
Cell 2007;129(3):447-50.
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2007: Feig Christine; Tchikov Vladimir; Schütze Stefan; Peter Marcus E
Palmitoylation of CD95 facilitates formation of SDS-stable receptor aggregates that initiate apoptosis signaling.
The EMBO journal 2007;26(1):221-31.
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2006: Su Jing; Rajapaksha Tharinda W; Peter Marcus E; Mrksich Milan
Assays of endogenous caspase activities: a comparison of mass spectrometry and fluorescence formats.
Analytical chemistry 2006;78(14):4945-51.
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2006: Zhang Manling; Park Sun-Mi; Wang Yue; Shah Ramila; Liu Ni; Murmann Andrea E; Wang Chyung-Ru; Peter Marcus E; Ashton-Rickardt Philip G
Serine protease inhibitor 6 protects cytotoxic T cells from self-inflicted injury by ensuring the integrity of cytotoxic granules.
Immunity 2006;24(4):451-61.
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2006: Lee Kyeong-Hee; Feig Christine; Tchikov Vladimir; Schickel Robert; Hallas Cora; Schütze Stefan; Peter Marcus E; Chan Andrew C
The role of receptor internalization in CD95 signaling.
The EMBO journal 2006;25(5):1009-23.
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2005: Lee J C; Wang G X; Schickling O; Peter M E
Fusing DEDD with ubiquitin changes its intracellular localization and apoptotic potential.
Apoptosis : an international journal on programmed cell death 2005;10(6):1483-95.
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2005: Park Sun-Mi; Schickel Robert; Peter Marcus E
Nonapoptotic functions of FADD-binding death receptors and their signaling molecules.
Current opinion in cell biology 2005;17(6):610-6.
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2005: Murmann Andrea E; Gao Juntao; Encinosa Marissa; Gautier Mathieu; Peter Marcus E; Eils Roland; Lichter Peter; Rowley Janet D
Local gene density predicts the spatial position of genetic loci in the interphase nucleus.
Experimental cell research 2005;311(1):14-26.
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2005: Vijayan S; Zhou P; Rajapaksha T W; Alegre M -L; Peter M E
Transplanted islets from lpr mice are resistant to autoimmune destruction in a model of streptozotocin-induced type I diabetes.
Apoptosis : an international journal on programmed cell death 2005;10(4):725-30.
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2005: Alappat Elizabeth C; Feig Christine; Boyerinas Benjamin; Volkland Jörg; Samuels Martin; Murmann Andrea E; Thorburn Andrew; Kidd Vincent J; Slaughter Clive A; Osborn Stephanie L; Winoto Astar; Tang Wei-Jen; Peter Marcus E
Phosphorylation of FADD at serine 194 by CKIalpha regulates its nonapoptotic activities.
Molecular cell 2005;19(3):321-32.
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2005: Peter Marcus E; Legembre Patrick; Barnhart Bryan C
Does CD95 have tumor promoting activities?
Biochimica et biophysica acta 2005;1755(1):25-36.
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2005: Barnhart B C; Pietras E M; Algeciras-Schimnich A; Salmena L; Sayama K; Hakem R; Peter M E
CD95 apoptosis resistance in certain cells can be overcome by noncanonical activation of caspase-8.
Cell death and differentiation 2005;12(1):25-37.
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2004: Legembre Patrick; Barnhart Bryan C; Zheng Lixin; Vijayan Shrijay; Straus Stephen E; Puck Jennifer; Dale Janet K; Lenardo Michael; Peter Marcus E
Induction of apoptosis and activation of NF-kappaB by CD95 require different signalling thresholds.
EMBO reports 2004;5(11):1084-9.
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2004: Legembre Patrick; Schickel Robert; Barnhart Bryan C; Peter Marcus E
Identification of SNF1/AMP kinase-related kinase as an NF-kappaB-regulated anti-apoptotic kinase involved in CD95-induced motility and invasiveness.
The Journal of biological chemistry 2004;279(45):46742-7.
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2004: Legembre Patrick; Barnhart Bryan C; Peter Marcus E
The relevance of NF-kappaB for CD95 signaling in tumor cells.
Cell cycle (Georgetown, Tex.) 2004;3(10):1235-9.
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2004: Peter Marcus E
The flip side of FLIP.
The Biochemical journal 2004;382(Pt 2):e1-3.
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2004: Barnhart Bryan C; Legembre Patrick; Pietras Eric; Bubici Concetta; Franzoso Guido; Peter Marcus E
CD95 ligand induces motility and invasiveness of apoptosis-resistant tumor cells.
The EMBO journal 2004;23(15):3175-85.
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2004: Dinsdale David; Lee Justine C; Dewson Grant; Cohen Gerald M; Peter Marcus E
Intermediate filaments control the intracellular distribution of caspases during apoptosis.
The American journal of pathology 2004;164(2):395-407.
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2003: Barnhart Bryan C; Lee Justine C; Alappat Elizabeth C; Peter Marcus E
The death effector domain protein family.
Oncogene 2003;22(53):8634-44.
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2003: Zazzeroni Francesca; Papa Salvatore; Algeciras-Schimnich Alicia; Alvarez Kellean; Melis Tiziana; Bubici Concetta; Majewski Nathan; Hay Nissim; De Smaele Enrico; Peter Marcus E; Franzoso Guido
Gadd45 beta mediates the protective effects of CD40 costimulation against Fas-induced apoptosis.
Blood 2003;102(9):3270-9.
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2003: Liu Ni; Raja Srikumar M; Zazzeroni Francesca; Metkar Sunil S; Shah Ramila; Zhang Manling; Wang Yue; Brömme Dieter; Russin William A; Lee Justine C; Peter Marcus E; Froelich Christopher J; Franzoso Guido; Ashton-Rickardt Philip G
NF-kappaB protects from the lysosomal pathway of cell death.
The EMBO journal 2003;22(19):5313-22.
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2003: Alappat Elizabeth C; Volkland Jörg; Peter Marcus E
Cell cycle effects by C-FADD depend on its C-terminal phosphorylation site.
The Journal of biological chemistry 2003;278(43):41585-8.
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2003: Algeciras-Schimnich Alicia; Pietras Eric M; Barnhart Bryan C; Legembre Patrick; Vijayan Shrijay; Holbeck Susan L; Peter Marcus E
Two CD95 tumor classes with different sensitivities to antitumor drugs.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(20):11445-50.
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2003: Chang David W; Xing Zheng; Capacio Vanessa L; Peter Marcus E; Yang Xiaolu
Interdimer processing mechanism of procaspase-8 activation.
The EMBO journal 2003;22(16):4132-42.
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2003: Barnhart Bryan C; Peter Marcus E
The TNF receptor 1: a split personality complex.
Cell 2003;114(2):148-50.
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2003: Algeciras-Schimnich Alicia; Peter Marcus E
Actin dependent CD95 internalization is specific for Type I cells.
FEBS letters 2003;546(2-3):185-8.
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2003: Barnhart Bryan C; Alappat Elizabeth C; Peter Marcus E
The CD95 type I/type II model.
Seminars in immunology 2003;15(3):185-93.
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2003: Lee Justine C; Peter Marcus E
Regulation of apoptosis by ubiquitination.
Immunological reviews 2003;193():39-47.
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2003: Peter M E; Krammer P H
The CD95(APO-1/Fas) DISC and beyond.
Cell death and differentiation 2003;10(1):26-35.
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2002: Algeciras-Schimnich Alicia; Barnhart Bryan C; Peter Marcus E
Apoptosis-independent functions of killer caspases.
Current opinion in cell biology 2002;14(6):721-6.
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2002: Barnhart Bryan C; Peter Marcus E
Two faces of caspase-8.
Nature immunology 2002;3(10):896-8.
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2002: Lee Justine C; Schickling Olaf; Stegh Alexander H; Oshima Robert G; Dinsdale David; Cohen Gerald M; Peter Marcus E
DEDD regulates degradation of intermediate filaments during apoptosis.
The Journal of cell biology 2002;158(6):1051-66.
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2002: Chang David W; Xing Zheng; Pan Yi; Algeciras-Schimnich Alicia; Barnhart Bryan C; Yaish-Ohad Shoshanit; Peter Marcus E; Yang Xiaolu
c-FLIP(L) is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis.
The EMBO journal 2002;21(14):3704-14.
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2002: Stegh Alexander H; Barnhart Bryan C; Volkland Jorg; Algeciras-Schimnich Alicia; Ke Ning; Reed John C; Peter Marcus E
Inactivation of caspase-8 on mitochondria of Bcl-xL-expressing MCF7-Fas cells: role for the bifunctional apoptosis regulator protein.
The Journal of biological chemistry 2002;277(6):4351-60.
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2002: Algeciras-Schimnich Alicia; Shen Le; Barnhart Bryan C; Murmann Andrea E; Burkhardt Janis K; Peter Marcus E
Molecular ordering of the initial signaling events of CD95.
Molecular and cellular biology 2002;22(1):207-20.
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2001: Schickling O; Stegh A H; Byrd J; Peter M E
Nuclear localization of DEDD leads to caspase-6 activation through its death effector domain and inhibition of RNA polymerase I dependent transcription.
Cell death and differentiation 2001;8(12):1157-68.
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2001: Chatterjee D; Schmitz I; Krueger A; Yeung K; Kirchhoff S; Krammer P H; Peter M E; Wyche J H; Pantazis P
Induction of apoptosis in 9-nitrocamptothecin-treated DU145 human prostate carcinoma cells correlates with de novo synthesis of CD95 and CD95 ligand and down-regulation of c-FLIP(short).
Cancer research 2001;61(19):7148-54.
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2001: Zheng L; Schickling O; Peter M E; Lenardo M J
The death effector domain-associated factor plays distinct regulatory roles in the nucleus and cytoplasm.
The Journal of biological chemistry 2001;276(34):31945-52.
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2001: Stegh A H; Peter M E
Apoptosis and caspases.
Cardiology clinics 2001;19(1):13-29.
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2000: Stegh A H; Herrmann H; Lampel S; Weisenberger D; Andrä K; Seper M; Wiche G; Krammer P H; Peter M E
Identification of the cytolinker plectin as a major early in vivo substrate for caspase 8 during CD95- and tumor necrosis factor receptor-mediated apoptosis.
Molecular and cellular biology 2000;20(15):5665-79.
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2000: Willems F; Amraoui Z; Vanderheyde N; Verhasselt V; Aksoy E; Scaffidi C; Peter M E; Krammer P H; Goldman M
Expression of c-FLIP(L) and resistance to CD95-mediated apoptosis of monocyte-derived dendritic cells: inhibition by bisindolylmaleimide.
Blood 2000;95(11):3478-82.
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2000: Scaffidi C; Volkland J; Blomberg I; Hoffmann I; Krammer P H; Peter M E
Phosphorylation of FADD/ MORT1 at serine 194 and association with a 70-kDa cell cycle-regulated protein kinase.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(3):1236-42.
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1999: Schmitz I; Walczak H; Krammer P H; Peter M E
Differences between CD95 type I and II cells detected with the CD95 ligand.
Cell death and differentiation 1999;6(9):821-2.
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1999: Scaffidi C; Schmitz I; Zha J; Korsmeyer S J; Krammer P H; Peter M E
Differential modulation of apoptosis sensitivity in CD95 type I and type II cells.
The Journal of biological chemistry 1999;274(32):22532-8.
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1999: Scaffidi C; Kirchhoff S; Krammer P H; Peter M E
Apoptosis signaling in lymphocytes.
Current opinion in immunology 1999;11(3):277-85.
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1999: Scaffidi C; Krammer P H; Peter M E
Isolation and analysis of components of CD95 (APO-1/Fas) death-inducing signaling complex.
Methods (San Diego, Calif.) 1999;17(4):287-91.
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1999: Scaffidi C; Schmitz I; Krammer P H; Peter M E
The role of c-FLIP in modulation of CD95-induced apoptosis.
The Journal of biological chemistry 1999;274(3):1541-8.
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1999: Peter M E; Scaffidi C; Medema J P; Kischkel F; Krammer P H
The death receptors.
Results and problems in cell differentiation 1999;23():25-63.
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1998: Fulda S; Scaffidi C; Susin S A; Krammer P H; Kroemer G; Peter M E; Debatin K M
Activation of mitochondria and release of mitochondrial apoptogenic factors by betulinic acid.
The Journal of biological chemistry 1998;273(51):33942-8.
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1998: Fulda S; Scaffidi C; Pietsch T; Krammer P H; Peter M E; Debatin K M
Activation of the CD95 (APO-1/Fas) pathway in drug- and gamma-irradiation-induced apoptosis of brain tumor cells.
Cell death and differentiation 1998;5(10):884-93.
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1998: Peter M E; Krammer P H
Mechanisms of CD95 (APO-1/Fas)-mediated apoptosis.
Current opinion in immunology 1998;10(5):545-51.
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1998: Stegh A H; Schickling O; Ehret A; Scaffidi C; Peterhänsel C; Hofmann T G; Grummt I; Krammer P H; Peter M E
DEDD, a novel death effector domain-containing protein, targeted to the nucleolus.
The EMBO journal 1998;17(20):5974-86.
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1998: Chlichlia K; Peter M E; Rocha M; Scaffidi C; Bucur M; Krammer P H; Schirrmacher V; Umansky V
Caspase activation is required for nitric oxide-mediated, CD95(APO-1/Fas)-dependent and independent apoptosis in human neoplastic lymphoid cells.
Blood 1998;91(11):4311-20.
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1998: Scaffidi C; Fulda S; Srinivasan A; Friesen C; Li F; Tomaselli K J; Debatin K M; Krammer P H; Peter M E
Two CD95 (APO-1/Fas) signaling pathways.
The EMBO journal 1998;17(6):1675-87.
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1998: Medema J P; Scaffidi C; Krammer P H; Peter M E
Bcl-xL acts downstream of caspase-8 activation by the CD95 death-inducing signaling complex.
The Journal of biological chemistry 1998;273(6):3388-93.
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1997: Medema J P; Toes R E; Scaffidi C; Zheng T S; Flavell R A; Melief C J; Peter M E; Offringa R; Krammer P H
Cleavage of FLICE (caspase-8) by granzyme B during cytotoxic T lymphocyte-induced apoptosis.
European journal of immunology 1997;27(12):3492-8.
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1997: Peter M E; Heufelder A E; Hengartner M O
Advances in apoptosis research.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(24):12736-7.
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1997: Fulda S; Friesen C; Los M; Scaffidi C; Mier W; Benedict M; Nuñez G; Krammer P H; Peter M E; Debatin K M
Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors.
Cancer research 1997;57(21):4956-64.
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1997: Peter M E; Medema J P; Krammer P H
Does the Caenorhabditis elegans protein CED-4 contain a region of homology to the mammalian death effector domain?
Cell death and differentiation 1997;4(7):523-5.
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1997: Scaffidi C; Medema J P; Krammer P H; Peter M E
FLICE is predominantly expressed as two functionally active isoforms, caspase-8/a and caspase-8/b.
The Journal of biological chemistry 1997;272(43):26953-8.
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1997: Medema J P; Scaffidi C; Kischkel F C; Shevchenko A; Mann M; Krammer P H; Peter M E
FLICE is activated by association with the CD95 death-inducing signaling complex (DISC).
The EMBO journal 1997;16(10):2794-804.
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1997: Chlichlia K; Busslinger M; Peter M E; Walczak H; Krammer P H; Schirrmacher V; Khazaie K
ICE-proteases mediate HTLV-I Tax-induced apoptotic T-cell death.
Oncogene 1997;14(19):2265-72.
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1997: Peter M E; Kischkel F C; Scheuerpflug C G; Medema J P; Debatin K M; Krammer P H
Resistance of cultured peripheral T cells towards activation-induced cell death involves a lack of recruitment of FLICE (MACH/caspase 8) to the CD95 death-inducing signaling complex.
European journal of immunology 1997;27(5):1207-12.
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1997: Thome M; Schneider P; Hofmann K; Fickenscher H; Meinl E; Neipel F; Mattmann C; Burns K; Bodmer J L; Schröter M; Scaffidi C; Krammer P H; Peter M E; Tschopp J
Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors.
Nature 1997;386(6624):517-21.
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1997: Peter M E; Ehret A; Berndt C; Krammer P H
AIDS and the death receptors.
British medical bulletin 1997;53(3):604-16.
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1996: Cahill M A; Peter M E; Kischkel F C; Chinnaiyan A M; Dixit V M; Krammer P H; Nordheim A
CD95 (APO-1/Fas) induces activation of SAP kinases downstream of ICE-like proteases.
Oncogene 1996;13(10):2087-96.
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1996: Ratter F; Germer M; Fischbach T; Schulze-Osthoff K; Peter M E; Dröge W; Krammer P H; Lehmann V
S-adenosylhomocysteine as a physiological modulator of Apo-1-mediated apoptosis.
International immunology 1996;8(7):1139-47.
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1996: Muzio M; Chinnaiyan A M; Kischkel F C; O'Rourke K; Shevchenko A; Ni J; Scaffidi C; Bretz J D; Zhang M; Gentz R; Mann M; Krammer P H; Peter M E; Dixit V M
FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex.
Cell 1996;85(6):817-27.
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1996: Walczak H; Dhein J; Peter M E; Krammer P H
Educational Corner: Activation-induced T cell death.
Cell death and differentiation 1996;3(2):245.
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1996: Peter M E; Kischkel F C; Hellbardt S; Chinnaiyan A M; Krammer P H; Dixit V M
CD95 (APO-1/Fas)-associating signalling proteins.
Cell death and differentiation 1996;3(2):161-70.
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1996: Chinnaiyan A M; Tepper C G; Seldin M F; O'Rourke K; Kischkel F C; Hellbardt S; Krammer P H; Peter M E; Dixit V M
FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis.
The Journal of biological chemistry 1996;271(9):4961-5.
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1995: Peter M E; Dhein J; Ehret A; Hellbardt S; Walczak H; Moldenhauer G; Krammer P H
APO-1 (CD95)-dependent and -independent antigen receptor-induced apoptosis in human T and B cell lines.
International immunology 1995;7(11):1873-7.
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1995: Kischkel F C; Hellbardt S; Behrmann I; Germer M; Pawlita M; Krammer P H; Peter M E
Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor.
The EMBO journal 1995;14(22):5579-88.
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1995: Schraven B; Peter M E
APO-1(CD95)-mediated apoptosis in Jurkat cells does not involve src kinases or CD45.
FEBS letters 1995;368(3):491-4.
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