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Alan Peterkofsky

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Chang-Ro Lee; Soyoung Park; Young-Ha Park; Alan Peterkofsky; Miri Kim; Yeon-Ran Kim; Yeong-Jae Seok
Reciprocal regulation of the autophosphorylation of enzyme I(Ntr) by glutamine and α-ketoglutarate in Escherichia coli.
Hyun-Jin Kim; Miri Kim; Chang-Ro Lee; Alan Peterkofsky; Yeong-Jae Seok
Dephosphorylated NPr of the nitrogen PTS regulates lipid A biosynthesis by direct interaction with LpxD.
Grzegorz Piszczek; Jennifer C Lee; Nico Tjandra; Chang-Ro Lee; Yeong-Jae Seok; Rodney L Levine; Alan Peterkofsky
Deuteration of Escherichia coli enzyme I(Ntr) alters its stability.

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2013: Chang-Ro Lee; Soyoung Park; Young-Ha Park; Alan Peterkofsky; Miri Kim; Yeon-Ran Kim; Yeong-Jae Seok
Reciprocal regulation of the autophosphorylation of enzyme I(Ntr) by glutamine and α-ketoglutarate in Escherichia coli.
Molecular microbiology 2013;88(3):473-85.
2011: Hyun-Jin Kim; Miri Kim; Chang-Ro Lee; Alan Peterkofsky; Yeong-Jae Seok
Dephosphorylated NPr of the nitrogen PTS regulates lipid A biosynthesis by direct interaction with LpxD.
Biochemical and biophysical research communications 2011;409(3):556-61.
2011: Grzegorz Piszczek; Jennifer C Lee; Nico Tjandra; Chang-Ro Lee; Yeong-Jae Seok; Rodney L Levine; Alan Peterkofsky
Deuteration of Escherichia coli enzyme I(Ntr) alters its stability.
Archives of biochemistry and biophysics 2011;507(2):332-42.
2010: Chang-Ro Lee; Seung-Hyon Cho; Hyun-Jin Kim; Miri Kim; Alan Peterkofsky; Yeong-Jae Seok
Potassium mediates Escherichia coli enzyme IIA(Ntr) -dependent regulation of sigma factor selectivity.
Molecular microbiology 2010;78(6):1468-83.
2010: Guangshun Wang; Karen M Watson; Alan Peterkofsky; Robert W Buckheit
Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database.
Antimicrobial agents and chemotherapy 2010;54(3):1343-6.
2008: Xia Li; Alan Peterkofsky; Guangshun Wang
Solution structure of NPr, a bacterial signal-transducing protein that controls the phosphorylation state of the potassium transporter-regulating protein IIA Ntr.
Amino acids 2008;35(3):531-9.
2007: Chang-Ro Lee; Seung-Hyon Cho; Mi-Jeong Yoon; Alan Peterkofsky; Yeong-Jae Seok
Escherichia coli enzyme IIANtr regulates the K+ transporter TrkA.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(10):4124-9.
2006: Alexey Teplyakov; Kap Lim; Peng-Peng Zhu; Geeta Kapadia; Celia C H Chen; Jennifer Schwartz; Andrew Howard; Prasad T Reddy; Alan Peterkofsky; Osnat Herzberg
Structure of phosphorylated enzyme I, the phosphoenolpyruvate:sugar phosphotransferase system sugar translocation signal protein.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(44):16218-23.
2006: Alan Peterkofsky; Guangshun Wang; Yeong-Jae Seok
Parallel PTS systems.
Archives of biochemistry and biophysics 2006;453(1):101-7.
2006: Xia Li; Yifeng Li; Alan Peterkofsky; Guangshun Wang
NMR studies of aurein 1.2 analogs.
Biochimica et biophysica acta 2006;1758(9):1203-14.
2006: Young-Ha Park; Byeong R Lee; Yeong-Jae Seok; Alan Peterkofsky
In vitro reconstitution of catabolite repression in Escherichia coli.
The Journal of biological chemistry 2006;281(10):6448-54.
2005: Chang-Ro Lee; Byoung-Mo Koo; Seung-Hyon Cho; Yu-Jung Kim; Mi-Jeong Yoon; Alan Peterkofsky; Yeong-Jae Seok
Requirement of the dephospho-form of enzyme IIANtr for derepression of Escherichia coli K-12 ilvBN expression.
Molecular microbiology 2005;58(1):334-44.
2005: David C Williams; Mengli Cai; Jeong-Yong Suh; Alan Peterkofsky; G Marius Clore
Solution NMR structure of the 48-kDa IIAMannose-HPr complex of the Escherichia coli mannose phosphotransferase system.
The Journal of biological chemistry 2005;280(21):20775-84.
2005: Guangshun Wang; Alan Peterkofsky; Paul A Keifer; Xia Li
NMR characterization of the Escherichia coli nitrogen regulatory protein IIANtr in solution and interaction with its partner protein, NPr.
Protein science : a publication of the Protein Society 2005;14(4):1082-90.
2004: Patricia M Legler; Mengli Cai; Alan Peterkofsky; G Marius Clore
Three-dimensional solution structure of the cytoplasmic B domain of the mannitol transporter IImannitol of the Escherichia coli phosphotransferase system.
The Journal of biological chemistry 2004;279(37):39115-21.
2004: Paul A Keifer; Alan Peterkofsky; Guangshun Wang
Effects of detergent alkyl chain length and chemical structure on the properties of a micelle-bound bacterial membrane targeting peptide.
Analytical biochemistry 2004;331(1):33-9.
2004: Byoung-Mo Koo; Mi-Jeong Yoon; Chang-Ro Lee; Tae-Wook Nam; Young-Jun Choe; Howard Jaffe; Alan Peterkofsky; Yeong-Jae Seok
A novel fermentation/respiration switch protein regulated by enzyme IIAGlc in Escherichia coli.
The Journal of biological chemistry 2004;279(30):31613-21.
2003: Xia Li; Alan Peterkofsky; Guangshun Wang
1H, 15N, and 13C chemical shift assignments of the Escherichia coli nitrogen regulatory phosphocarrier IIA(Ntr).
Journal of biomolecular NMR 2003;27(4):401-2.
2003: Mariana N Dimitrova; Alan Peterkofsky; Ann Ginsburg
Opposing effects of phosphoenolpyruvate and pyruvate with Mg(2+) on the conformational stability and dimerization of phosphotransferase enzyme I from Escherichia coli.
Protein science : a publication of the Protein Society 2003;12(9):2047-56.
2003: Prasad T Reddy; C Rama Prasad; P Hemalatha Reddy; Dennis J Reeder; keith h mckenney; Howard Jaffe; Mariana N Dimitrova; Ann Ginsburg; Alan Peterkofsky; P Suryanarayana Murthy
Cloning and expression of the gene for a novel protein from Mycobacterium smegmatis with functional similarity to eukaryotic calmodulin.
Journal of bacteriology 2003;185(17):5263-8.
2003: Melissa Sondej; José Luis Vázquez-Ibar; Arta Farshidi; Alan Peterkofsky; H Ronald Kaback
Characterization of a lactose permease mutant that binds IIAGlc in the absence of ligand.
Biochemistry 2003;42(30):9153-9.
2003: Mengli Cai; David C Williams; Guangshun Wang; Byeong Ryong Lee; Alan Peterkofsky; G Marius Clore
Solution structure of the phosphoryl transfer complex between the signal-transducing protein IIAGlucose and the cytoplasmic domain of the glucose transporter IICBGlucose of the Escherichia coli glucose phosphotransferase system.
The Journal of biological chemistry 2003;278(27):25191-206.
2003: Guangshun Wang; Paul A Keifer; Alan Peterkofsky
Solution structure of the N-terminal amphitropic domain of Escherichia coli glucose-specific enzyme IIA in membrane-mimetic micelles.
Protein science : a publication of the Protein Society 2003;12(5):1087-96.
2002: Gabriel Cornilescu; Byeong Ryong Lee; Claudia C Cornilescu; Guangshun Wang; Alan Peterkofsky; G Marius Clore
Solution structure of the phosphoryl transfer complex between the cytoplasmic A domain of the mannitol transporter IIMannitol and HPr of the Escherichia coli phosphotransferase system.
The Journal of biological chemistry 2002;277(44):42289-98.
2002: Melissa Sondej; Adam B Weinglass; Alan Peterkofsky; H Ronald Kaback
Binding of enzyme IIAGlc, a component of the phosphoenolpyruvate:sugar phosphotransferase system, to the Escherichia coli lactose permease.
Biochemistry 2002;41(17):5556-65.
2002: Mariana N Dimitrova; Roman H Szczepanowski; Sergei B Ruvinov; Alan Peterkofsky; Ann Ginsburg
Interdomain interaction and substrate coupling effects on dimerization and conformational stability of enzyme I of the Escherichia coli phosphoenolpyruvate:sugar phosphotransferase system.
Biochemistry 2002;41(3):906-13.
2002: Ann Ginsburg; Alan Peterkofsky
Enzyme I: the gateway to the bacterial phosphoenolpyruvate:sugar phosphotransferase system.
Archives of biochemistry and biophysics 2002;397(2):273-8.
2001: Yeong-Jae Seok; Byoung-Mo Koo; Melissa Sondej; Alan Peterkofsky
Regulation of E. coli glycogen phosphorylase activity by HPr.
Journal of molecular microbiology and biotechnology 2001;3(3):385-93.
2001: Alan Peterkofsky; Guangshun Wang; Daniel S Garrett; B R Lee; Yeong-Jae Seok; G Marius Clore
Three-dimensional structures of protein-protein complexes in the E. coli PTS.
Journal of molecular microbiology and biotechnology 2001;3(3):347-54.
2001: T W Nam; S H Cho; D Shin; J H Kim; J Y Jeong; J H Lee; Jung-Hye Roe; Alan Peterkofsky; S O Kang; S Ryu; Yeong-Jae Seok
The Escherichia coli glucose transporter enzyme IICB(Glc) recruits the global repressor Mlc.
The EMBO journal 2001;20(3):491-8.
2000: Guangshun Wang; Alan Peterkofsky; G Marius Clore
A novel membrane anchor function for the N-terminal amphipathic sequence of the signal-transducing protein IIAGlucose of the Escherichia coli phosphotransferase system.
The Journal of biological chemistry 2000;275(51):39811-4.
2000: Guangshun Wang; J M Louis; Melissa Sondej; Yeong-Jae Seok; Alan Peterkofsky; G Marius Clore
Solution structure of the phosphoryl transfer complex between the signal transducing proteins HPr and IIA(glucose) of the Escherichia coli phosphoenolpyruvate:sugar phosphotransferase system.
The EMBO journal 2000;19(21):5635-49.
2000: Guangshun Wang; Melissa Sondej; Daniel S Garrett; Alan Peterkofsky; G Marius Clore
A common interface on histidine-containing phosphocarrier protein for interaction with its partner proteins.
The Journal of biological chemistry 2000;275(22):16401-3.
2000: Ann Ginsburg; Roman H Szczepanowski; Sergei B Ruvinov; Neil Nosworthy; Melissa Sondej; T C Umland; Alan Peterkofsky
Conformational stability changes of the amino terminal domain of enzyme I of the Escherichia coli phosphoenolpyruvate: sugar phosphotransferase system produced by substituting alanine or glutamate for the active-site histidine 189: implications for phosphorylation effects.
Protein science : a publication of the Protein Society 2000;9(6):1085-94.
2000: Melissa Sondej; Yeong-Jae Seok; P Badawi; Byoung-Mo Koo; Tae-Wook Nam; Alan Peterkofsky
Topography of the surface of the Escherichia coli phosphotransferase system protein enzyme IIAglc that interacts with lactose permease.
Biochemistry 2000;39(11):2931-9.
1999: Peng-Peng Zhu; Roman H Szczepanowski; Neil Nosworthy; Ann Ginsburg; Alan Peterkofsky
Reconstitution studies using the helical and carboxy-terminal domains of enzyme I of the phosphoenolpyruvate:sugar phosphotransferase system.
Biochemistry 1999;38(47):15470-9.
1999: Melissa Sondej; Jason Sun; Yeong-Jae Seok; H Ronald Kaback; Alan Peterkofsky
Deduction of consensus binding sequences on proteins that bind IIAGlc of the phosphoenolpyruvate:sugar phosphotransferase system by cysteine scanning mutagenesis of Escherichia coli lactose permease.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(7):3525-30.
1999: Daniel S Garrett; Yeong-Jae Seok; Alan Peterkofsky; Angela M Gronenborn; G Marius Clore
Solution structure of the 40,000 Mr phosphoryl transfer complex between the N-terminal domain of enzyme I and HPr.
Nature structural biology 1999;6(2):166-73.
1998: Yeong-Jae Seok; Peng-Peng Zhu; Byoung-Mo Koo; Alan Peterkofsky
Autophosphorylation of enzyme I of the Escherichia coli phosphoenolpyruvate:sugar phosphotransferase system requires dimerization.
Biochemical and biophysical research communications 1998;250(2):381-4.
1998: Peng-Peng Zhu; Osnat Herzberg; Alan Peterkofsky
Topography of the interaction of HPr(Ser) kinase with HPr.
Biochemistry 1998;37(34):11762-70.
1998: K Huang; Geeta Kapadia; Peng-Peng Zhu; Alan Peterkofsky; Osnat Herzberg
A promiscuous binding surface: crystal structure of the IIA domain of the glucose-specific permease from Mycoplasma capricolum.
Structure (London, England : 1993) 1998;6(6):697-710.
1998: Neil Nosworthy; Alan Peterkofsky; Simone Koenig; Yeong-Jae Seok; Roman H Szczepanowski; Ann Ginsburg
Phosphorylation destabilizes the amino-terminal domain of enzyme I of the Escherichia coli phosphoenolpyruvate:sugar phosphotransferase system.
Biochemistry 1998;37(19):6718-26.
1998: Daniel S Garrett; Yeong-Jae Seok; Alan Peterkofsky; G Marius Clore; Angela M Gronenborn
Tautomeric state and pKa of the phosphorylated active site histidine in the N-terminal domain of enzyme I of the Escherichia coli phosphoenolpyruvate:sugar phosphotransferase system.
Protein science : a publication of the Protein Society 1998;7(3):789-93.
1997: Yeong-Jae Seok; Jason Sun; H Ronald Kaback; Alan Peterkofsky
Topology of allosteric regulation of lactose permease.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(25):13515-9.
1997: Yeong-Jae Seok; Melissa Sondej; P Badawi; M S Lewis; M C Briggs; Howard Jaffe; Alan Peterkofsky
High affinity binding and allosteric regulation of Escherichia coli glycogen phosphorylase by the histidine phosphocarrier protein, HPr.
The Journal of biological chemistry 1997;272(42):26511-21.
1997: Peng-Peng Zhu; Neil Nosworthy; Ann Ginsburg; M Miyata; Yeong-Jae Seok; Alan Peterkofsky
Expression, purification, and characterization of enzyme IIA(glc) of the phosphoenolpyruvate:sugar phosphotransferase system of Mycoplasma capricolum.
Biochemistry 1997;36(23):6947-53.
1997: Daniel S Garrett; Yeong-Jae Seok; Alan Peterkofsky; G Marius Clore; Angela M Gronenborn
Identification by NMR of the binding surface for the histidine-containing phosphocarrier protein HPr on the N-terminal domain of enzyme I of the Escherichia coli phosphotransferase system.
Biochemistry 1997;36(15):4393-8.
1997: Daniel S Garrett; Yeong-Jae Seok; D I Liao; Alan Peterkofsky; Angela M Gronenborn; G Marius Clore
Solution structure of the 30 kDa N-terminal domain of enzyme I of the Escherichia coli phosphoenolpyruvate:sugar phosphotransferase system by multidimensional NMR.
Biochemistry 1997;36(9):2517-30.
1996: Peng-Peng Zhu; Alan Peterkofsky
Sequence and organization of genes encoding enzymes involved in pyruvate metabolism in Mycoplasma capricolum.
Protein science : a publication of the Protein Society 1996;5(8):1719-36.
1996: D I Liao; E Silverton; Yeong-Jae Seok; B R Lee; Alan Peterkofsky; David Davies
The first step in sugar transport: crystal structure of the amino terminal domain of enzyme I of the E. coli PEP: sugar phosphotransferase system and a model of the phosphotransfer complex with HPr.
Structure (London, England : 1993) 1996;4(7):861-72.
1996: Yeong-Jae Seok; B R Lee; C Gazdar; I Svenson; N Yadla; Alan Peterkofsky
Importance of the region around glycine-338 for the activity of enzyme I of the Escherichia coli phosphoenolpyruvate:sugar phosphotransferase system.
Biochemistry 1996;35(1):236-42.
1996: Yeong-Jae Seok; B R Lee; Peng-Peng Zhu; Alan Peterkofsky
Importance of the carboxyl-terminal domain of enzyme I of the Escherichia coli phosphoenolpyruvate: sugar phosphotransferase system for phosphoryl donor specificity.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(1):347-51.
1995: U Pieper; Geeta Kapadia; Peng-Peng Zhu; Alan Peterkofsky; Osnat Herzberg
Structural evidence for the evolutionary divergence of mycoplasma from gram-positive bacteria: the histidine-containing phosphocarrier protein.
Structure (London, England : 1993) 1995;3(8):781-90.
1995: Alan Peterkofsky; Yeong-Jae Seok; Niranjana Amin; Roopa Thapar; S Y Lee; Rachel E Klevit; E Bruce Waygood; J W Anderson; James M Gruschus; H Huq
The Escherichia coli adenylyl cyclase complex: requirement of PTS proteins for stimulation by nucleotides.
Biochemistry 1995;34(28):8950-9.
1995: Niranjana Amin; Alan Peterkofsky
A dual mechanism for regulating cAMP levels in Escherichia coli.
The Journal of biological chemistry 1995;270(20):11803-5.
1995: Peng-Peng Zhu; P Lecchi; Lewis K Pannell; H Jaffe; Alan Peterkofsky
Overproduction and purification of the Mycoplasma capricolum phosphocarrier protein, HPr, of the phosphoenolpyruvate: sugar phosphotransferase system.
Protein expression and purification 1995;6(2):189-95.
1994: Niranjana Amin; Alan Peterkofsky
Importance of the region around lysine 196 for catalytic activity of adenylyl cyclase from Escherichia coli.
The Journal of biological chemistry 1994;269(49):31074-9.
1994: Peng-Peng Zhu; J Reizer; Alan Peterkofsky
Unique dicistronic operon (ptsI-crr) in Mycoplasma capricolum encoding enzyme I and the glucose-specific enzyme IIA of the phosphoenolpyruvate:sugar phosphotransferase system: cloning, sequencing, promoter analysis, and protein characterization.
Protein science : a publication of the Protein Society 1994;3(11):2115-28.
1994: B R Lee; P Lecchi; Lewis K Pannell; H Jaffe; Alan Peterkofsky
Identification of the N-terminal domain of enzyme I of the Escherichia coli phosphoenolpyruvate:sugar phosphotransferase system produced by proteolytic digestion.
Archives of biochemistry and biophysics 1994;312(1):121-4.
1993: Peng-Peng Zhu; J Reizer; A Reizer; Alan Peterkofsky
Unique monocistronic operon (ptsH) in Mycoplasma capricolum encoding the phosphocarrier protein, HPr, of the phosphoenolpyruvate:sugar phosphotransferase system. Cloning, sequencing, and characterization of ptsH.
The Journal of biological chemistry 1993;268(35):26531-40.
1993: Alan Peterkofsky; N Gollop
The Escherichia coli adenylyl cyclase complex: stimulation by GTP and other nucleotides.
Protein science : a publication of the Protein Society 1993;2(4):498-505.
1993: Alan Peterkofsky; A Reizer; J Reizer; N Gollop; Peng-Peng Zhu; Niranjana Amin
Bacterial adenylyl cyclases.
Progress in nucleic acid research and molecular biology 1993;44():31-65.
1992: N Amin; Alan Peterkofsky
Requirement for GLY-60 of Escherichia coli adenylyl cyclase for ATP binding and catalytic activity.
Biochemical and biophysical research communications 1992;182(3):1218-25.
1991: P Reddy; N Fredd-Kuldell; E Liberman; Alan Peterkofsky
Overproduction and rapid purification of the phosphoenolpyruvate:sugar phosphotransferase system proteins enzyme I, HPr, and Protein IIIGlc of Escherichia coli.
Protein expression and purification 1991;2(2-3):179-87.
1989: P Reddy; Alan Peterkofsky; keith h mckenney
Hyperexpression and purification of Escherichia coli adenylate cyclase using a vector designed for expression of lethal gene products.
Nucleic acids research 1989;17(24):10473-88.
1989: Alan Peterkofsky; I Svenson; Niranjana Amin
Regulation of Escherichia coli adenylate cyclase activity by the phosphoenolpyruvate:sugar phosphotransferase system.
FEMS microbiology reviews 1989;5(1-2):103-8.
1989: M C Vaney; Gary L Gilliland; J G Harman; Alan Peterkofsky; Irene T Weber
Crystal structure of a cAMP-independent form of catabolite gene activator protein with adenosine substituted in one of two cAMP-binding sites.
Biochemistry 1989;28(11):4568-74.
1988: Alan Peterkofsky
Redistribution of phosphate pools and the regulation of Escherichia coli adenylate cyclase activity.
Archives of biochemistry and biophysics 1988;265(2):227-33.
1988: J G Harman; Alan Peterkofsky; keith h mckenney
Arginine substituted for leucine at position 195 produces a cyclic AMP-independent form of the Escherichia coli cyclic AMP receptor protein.
The Journal of biological chemistry 1988;263(17):8072-7.
1988: J Reizer; Alan Peterkofsky; A H Romano
Evidence for the presence of heat-stable protein (HPr) and ATP-dependent HPr kinase in heterofermentative lactobacilli lacking phosphoenolpyruvate:glycose phosphotransferase activity.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(7):2041-5.
1987: Irene T Weber; Gary L Gilliland; J G Harman; Alan Peterkofsky
Crystal structure of a cyclic AMP-independent mutant of catabolite gene activator protein.
The Journal of biological chemistry 1987;262(12):5630-6.
1986: E Liberman; D Saffen; Saul Roseman; Alan Peterkofsky
Inhibition of E. coli adenylate cyclase activity by inorganic orthophosphate is dependent on IIIglc of the phosphoenolpyruvate:glycose phosphotransferase system.
Biochemical and biophysical research communications 1986;141(3):1138-44.
1986: J G Harman; keith h mckenney; Alan Peterkofsky
Structure-function analysis of three cAMP-independent forms of the cAMP receptor protein.
The Journal of biological chemistry 1986;261(35):16332-9.
1985: P Reddy; Alan Peterkofsky; keith h mckenney
Translational efficiency of the Escherichia coli adenylate cyclase gene: mutating the UUG initiation codon to GUG or AUG results in increased gene expression.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(17):5656-60.
1985: E Liberman; P Reddy; C Gazdar; Alan Peterkofsky
The Escherichia coli adenylate cyclase complex. Stimulation by potassium and phosphate.
The Journal of biological chemistry 1985;260(7):4075-81.
1983: R Puskas; N Fredd; C Gazdar; Alan Peterkofsky
Methylglyoxal-mediated growth inhibition in an Escherichia coli cAMP receptor protein mutant.
Archives of biochemistry and biophysics 1983;223(2):503-13.