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Godefridus Peters

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
144
PINEDO, HERBERT
66
van Groeningen, Cees
56
Van der Wilt, Clasina
53
Noordhuis, Paul
53
Smid, Kees
42
Jansen, Gerrit
33
Giaccone, Giuseppe
33
Veerman, Gijsbert
29
Bergman, André
24
Kaspers, G J L
23
Pieters, Rob
21
Ruiz van Haperen, Veronique
20
Voorn, Daphne
20
Van Moorsel, Catharina
19
Veerman, Anjo

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Publications

TOP 3
Mayur Yergeri C; Peters Godefridus J; Lemos Clara; Kathmann Ietje; Prasad Velivela V S Rajendra
Synthesis of 2-fluoro N(10)-substituted acridones and their cytotoxicity studies in sensitive and resistant cancer cell lines and their DNA intercalation studies.
van Riel J M; Peters G J; Mammatas L H; Honeywell R J; Laan A C; Ruyter R; van den Berg F G; Giaccone G; van Groeningen C J
A phase I and pharmacokinetic study of gemcitabine given by 24-h hepatic arterial infusion.
Mauritz Robert; Giovannetti Elisa; Beumer Ines J; Smid Kees; Van Groeningen Cees J; Pinedo Herbert M; Peters Godefridus J
Polymorphisms in the enhancer region of the thymidylate synthase gene are associated with thymidylate synthase levels in normal tissues but not in malignant tissues of patients with colorectal cancer.

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All Publications

2009: Mayur Yergeri C; Peters Godefridus J; Lemos Clara; Kathmann Ietje; Prasad Velivela V S Rajendra
Synthesis of 2-fluoro N(10)-substituted acridones and their cytotoxicity studies in sensitive and resistant cancer cell lines and their DNA intercalation studies.
Archiv der Pharmazie 2009;342(11):640-50.
2009: van Riel J M; Peters G J; Mammatas L H; Honeywell R J; Laan A C; Ruyter R; van den Berg F G; Giaccone G; van Groeningen C J
A phase I and pharmacokinetic study of gemcitabine given by 24-h hepatic arterial infusion.
European journal of cancer (Oxford, England : 1990) 2009;45(14):2519-27.
2009: Mauritz Robert; Giovannetti Elisa; Beumer Ines J; Smid Kees; Van Groeningen Cees J; Pinedo Herbert M; Peters Godefridus J
Polymorphisms in the enhancer region of the thymidylate synthase gene are associated with thymidylate synthase levels in normal tissues but not in malignant tissues of patients with colorectal cancer.
Clinical colorectal cancer 2009;8(3):146-54.
2009: Crea Francesco; Giovannetti Elisa; Cortesi Filippo; Mey Valentina; Nannizzi Sara; Gallegos Ruiz Marielle I; Ricciardi Simona; Del Tacca Mario; Peters Godefridus J; Danesi Romano
Epigenetic mechanisms of irinotecan sensitivity in colorectal cancer cell lines.
Molecular cancer therapeutics 2009;8(7):1964-73.
2009: Adema A D; van der Born K; Honeywell R J; Peters G J
Cell cycle effects and increased adduct formation by temozolomide enhance the effect of cytotoxic and targeted agents in lung cancer cell lines.
Journal of chemotherapy (Florence, Italy) 2009;21(3):338-46.
2009: Fotoohi Alan Kambiz; Assaraf Yehuda G; Moshfegh Ali; Hashemi Jamileh; Jansen Gerrit; Peters Godefridus J; Larsson Catharina; Albertioni Freidoun
Gene expression profiling of leukemia T-cells resistant to methotrexate and 7-hydroxymethotrexate reveals alterations that preserve intracellular levels of folate and nucleotide biosynthesis.
Biochemical pharmacology 2009;77(8):1410-7.
2009: Lemos C; Kathmann I; Giovannetti E; Calhau C; Jansen G; Peters G J
Impact of cellular folate status and epidermal growth factor receptor expression on BCRP/ABCG2-mediated resistance to gefitinib and erlotinib.
British journal of cancer 2009;100(7):1120-7.
2009: Lemos Clara; Kathmann Ietje; Giovannetti Elisa; Beliën Jeroen A M; Scheffer George L; Calhau Conceição; Jansen Gerrit; Peters Godefridus J
Cellular folate status modulates the expression of BCRP and MRP multidrug transporters in cancer cell lines from different origins.
Molecular cancer therapeutics 2009;8(3):655-64.
2009: de Jonge Robert; Tissing Wim J E; Hooijberg Jan Hendrik; Jansen Gerrit; Kaspers Gertjan J L; Lindemans Jan; Peters Godefridus J; Pieters Rob
Polymorphisms in folate-related genes and risk of pediatric acute lymphoblastic leukemia.
Blood 2009;113(10):2284-9.
2009: Galleges Ruiz M I; Floor K; Steinberg S M; Grünberg K; Thunnissen F B J M; Belien J A M; Meijer G A; Peters G J; Smit E F; Rodriguez J A; Giaccone G
Combined assessment of EGFR pathway-related molecular markers and prognosis of NSCLC patients.
British journal of cancer 2009;100(1):145-52.
2009: Porcelli Letizia; Lemos Clara; Peters Godefridus J; Paradiso Angelo; Azzariti Amalia
Intracellular trafficking of MDR transporters and relevance of SNPs.
Current topics in medicinal chemistry 2009;9(2):197-208.
2008: Bijnsdorp I V; Kruyt F A; Gokoel S; Fukushima M; Peters G J
Synergistic interaction between trifluorothymidine and docetaxel is sequence dependent.
Cancer science 2008;99(11):2302-8.
2008: Mauritz Robert; Peters Godefridus J; Kathmann Ietje; Teshale Habte; Noordhuis Paul; Comijn Elizabeth M; Pinedo Herbert M; Jansen Gerrit
Dynamics of antifolate transport via the reduced folate carrier and the membrane folate receptor in murine leukaemia cells in vitro and in vivo.
Cancer chemotherapy and pharmacology 2008;62(6):937-48.
2008: Lemos Clara; Kathmann Ietje; Giovannetti Elisa; Dekker Henk; Scheffer George L; Calhau Conceição; Jansen Gerrit; Peters Godefridus J
Folate deprivation induces BCRP (ABCG2) expression and mitoxantrone resistance in Caco-2 cells.
International journal of cancer. Journal international du cancer 2008;123(7):1712-20.
2008: Tekle C; Giovannetti E; Sigmond J; Graff J R; Smid K; Peters G J
Molecular pathways involved in the synergistic interaction of the PKC beta inhibitor enzastaurin with the antifolate pemetrexed in non-small cell lung cancer cells.
British journal of cancer 2008;99(5):750-9.
2008: Oerlemans Ruud; Franke Niels E; Assaraf Yehuda G; Cloos Jacqueline; van Zantwijk Ina; Berkers Celia R; Scheffer George L; Debipersad Kabir; Vojtekova Katharina; Lemos Clara; van der Heijden Joost W; Ylstra Bauke; Peters Godefridus J; Kaspers Gertjan L; Dijkmans Ben A C; Scheper Rik J; Jansen Gerrit
Molecular basis of bortezomib resistance: proteasome subunit beta5 (PSMB5) gene mutation and overexpression of PSMB5 protein.
Blood 2008;112(6):2489-99.
2008: Direcks W G E; Berndsen S C; Proost N; Peters G J; Balzarini J; Spreeuwenberg M D; Lammertsma A A; Molthoff C F M
[18F]FDG and [18F]FLT uptake in human breast cancer cells in relation to the effects of chemotherapy: an in vitro study.
British journal of cancer 2008;99(3):481-7.
2008: Staffhorst Rutger W H M; van der Born Kasper; Erkelens Caroline A M; Hamelers Irene H L; Peters Godefridus J; Boven Epie; de Kroon Anton I P M
Antitumor activity and biodistribution of cisplatin nanocapsules in nude mice bearing human ovarian carcinoma xenografts.
Anti-cancer drugs 2008;19(7):721-7.
2008: Noordhuis Paul; Laan Adri C; van de Born Kasper; Losekoot Nienke; Kathmann Ietje; Peters Godefridus J
Oxaliplatin activity in selected and unselected human ovarian and colorectal cancer cell lines.
Biochemical pharmacology 2008;76(1):53-61.
2008: Hubeek I; Giovannetti E; Broekhuizen A J F; Pastor-Anglada M; Kaspers G J L; Peters G J
Immunocytochemical detection of hENT1 and hCNT1 in normal tissues, lung cancer cell lines, and NSCLC patient samples.
Nucleosides, nucleotides & nucleic acids 2008;27(6):787-93.
2008: Giovannetti E; Backus H H J; Wouters D; Peters G J
Functional inactivity and mutations of p53 differentially affect sensitivity to 5-fluorouracil and antifolate inhibitors of thymidylate synthase (TS) by altering TS levels in colorectal cancer cells.
Nucleosides, nucleotides & nucleic acids 2008;27(6):740-5.
2008: Codacci-Pisanelli G; Noordhuis P; van der Wilt C L; Peters G J
Selective protection by uridine of growth inhibition by 5-fluorouracil (5FU) mediated by 5FU incorporation into RNA, but not the thymidylate synthase mediated growth inhibition by 5FU-leucovorin.
Nucleosides, nucleotides & nucleic acids 2008;27(6):733-9.
2008: Giovannetti E; Laan A C; Vasile E; Tibaldi C; Nannizzi S; Ricciardi S; Falcone A; Danesi R; Peters G J
Correlation between cytidine deaminase genotype and gemcitabine deamination in blood samples.
Nucleosides, nucleotides & nucleic acids 2008;27(6):720-5.
2008: Bijnsdorp I V; Kruyt F A; Fukushima M; Peters G J
Trifluorothymidine induces cell death independently of p53.
Nucleosides, nucleotides & nucleic acids 2008;27(6):699-703.
2008: Bijnsdorp I V; de Bruin M; Laan A C; Fukushima M; Peters G J
The role of platelet-derived endothelial cell growth factor/thymidine phosphorylase in tumor behavior.
Nucleosides, nucleotides & nucleic acids 2008;27(6):681-91.
2008: Hubeek I; Comijn E M; Van der Wilt C L; Merriman R L; Padron J M; Kaspers G J L; Peters G J
CI-994 (N-acetyl-dinaline) in combination with conventional anti-cancer agents is effective against acute myeloid leukemia in vitro and in vivo.
Oncology reports 2008;19(6):1517-23.
2008: Giovannetti Elisa; Lemos Clara; Tekle Christina; Smid Kees; Nannizzi Sara; Rodriguez José A; Ricciardi Simona; Danesi Romano; Giaccone Giuseppe; Peters Godefridus J
Molecular mechanisms underlying the synergistic interaction of erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor, with the multitargeted antifolate pemetrexed in non-small-cell lung cancer cells.
Molecular pharmacology 2008;73(4):1290-300.
2008: Tibaldi Carmelo; Giovannetti Elisa; Vasile Enrico; Mey Valentina; Laan Adrie C; Nannizzi Sara; Di Marsico Roberta; Antonuzzo Andrea; Orlandini Cinzia; Ricciardi Simona; Del Tacca Mario; Peters Godefridus J; Falcone Alfredo; Danesi Romano
Correlation of CDA, ERCC1, and XPD polymorphisms with response and survival in gemcitabine/cisplatin-treated advanced non-small cell lung cancer patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(6):1797-803.
2008: Lemos C; Jansen G; Peters G J
Drug transporters: recent advances concerning BCRP and tyrosine kinase inhibitors.
British journal of cancer 2008;98(5):857-62.
2008: Bijman Marcel N A; Hermelink Cristian A; van Berkel Maria P A; Laan Adrie C; Janmaat Maarten L; Peters Godefridus J; Boven Epie
Interaction between celecoxib and docetaxel or cisplatin in human cell lines of ovarian cancer and colon cancer is independent of COX-2 expression levels.
Biochemical pharmacology 2008;75(2):427-37.
2008: Giovannetti Elisa; Ugrasena Dewa G; Supriyadi Eddy; Vroling Laura; Azzarello Antonino; de Lange Desiree; Peters Godefridus J; Veerman Anjo J P; Cloos Jacqueline
Methylenetetrahydrofolate reductase (MTHFR) C677T and thymidylate synthase promoter (TSER) polymorphisms in Indonesian children with and without leukemia.
Leukemia research 2008;32(1):19-24.
2008: Bijnsdorp I V; Schwendener R A; Schott H; Schott S; Fichtner I; Honeywell R J; Losekoot N; Laan A C; Peters G J
In vitro activity and mechanism of action of a duplex and multidrug of ethynylcytidine and 5-fluorodeoxyuridine.
Nucleic acids symposium series (2004) 2008;(52):651.
2007: Fontijn Dennis; Adema Auke D; Bhakat Kishor K; Pinedo Herbert M; Peters Godefridus J; Boven Epie
O6-methylguanine-DNA-methyltransferase promoter demethylation is involved in basic fibroblast growth factor induced resistance against temozolomide in human melanoma cells.
Molecular cancer therapeutics 2007;6(10):2807-15.
2007: Lemos Clara; Peters Godefridus J; Jansen Gerrit; Martel Fátima; Calhau Conceição
Modulation of folate uptake in cultured human colon adenocarcinoma Caco-2 cells by dietary compounds.
European journal of nutrition 2007;46(6):329-36.
2007: Wu Weidong; Sigmond Jennifer; Peters Godefridus J; Borch Richard F
Synthesis and biological activity of a gemcitabine phosphoramidate prodrug.
Journal of medicinal chemistry 2007;50(15):3743-6.
2007: Bijnsdorp I V; Comijn E M; Padron J M; Gmeiner W H; Peters G J
Mechanisms of action of FdUMP[10]: metabolite activation and thymidylate synthase inhibition.
Oncology reports 2007;18(1):287-91.
2007: Voortman Jens; Smit Egbert F; Honeywell Richard; Kuenen Bart C; Peters Godefridus J; van de Velde Helgi; Giaccone Giuseppe
A parallel dose-escalation study of weekly and twice-weekly bortezomib in combination with gemcitabine and cisplatin in the first-line treatment of patients with advanced solid tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(12):3642-51.
2007: Temmink Olaf H; Emura Tomohiro; de Bruin Michiel; Fukushima Masakazu; Peters Godefridus J
Therapeutic potential of the dual-targeted TAS-102 formulation in the treatment of gastrointestinal malignancies.
Cancer science 2007;98(6):779-89.
2007: Mauritz Robert; van Groeningen Cees J; Smid Kees; Jansen Gerrit; Pinedo Herbert M; Peters Godefridus J
Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expression after administration of 5-fluorouracil to patients with colorectal cancer.
International journal of cancer. Journal international du cancer 2007;120(12):2609-12.
2007: Radi Marco; Adema Auke D; Daft Jonathan R; Cho Jong H; Hoebe Eveline K; Alexander Lou-Ella M M; Peters Godefridus J; Chu Chung K
In vitro optimization of non-small cell lung cancer activity with troxacitabine, L-1,3-dioxolane-cytidine, prodrugs.
Journal of medicinal chemistry 2007;50(9):2249-53.
2007: Sigmond J; Kamphuis J A E; Laan A C; Hoebe E K; Bergman A M; Peters G J
The synergistic interaction of gemcitabine and cytosine arabinoside with the ribonucleotide reductase inhibitor triapine is schedule dependent.
Biochemical pharmacology 2007;73(10):1548-57.
2007: Wittgen Bart P H; Kunst Peter W A; van der Born Kasper; van Wijk Atie W; Perkins Walter; Pilkiewicz Frank G; Perez-Soler Roman; Nicholson Susan; Peters Godefridus J; Postmus Pieter E
Phase I study of aerosolized SLIT cisplatin in the treatment of patients with carcinoma of the lung.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(8):2414-21.
2007: Peters G J; Clavel M; Noordhuis P; Geyssen G J; Laan A C; Guastalla J; Edzes H T; Vermorken J B
Clinical phase I and pharmacology study of gemcitabine (2', 2'-difluorodeoxycytidine) administered in a two-weekly schedule.
Journal of chemotherapy (Florence, Italy) 2007;19(2):212-21.
2007: Giovannetti E; Backus H H J; Wouters D; Ferreira C G; van Houten V M M; Brakenhoff R H; Poupon M-F; Azzarello A; Pinedo H M; Peters G J
Changes in the status of p53 affect drug sensitivity to thymidylate synthase (TS) inhibitors by altering TS levels.
British journal of cancer 2007;96(5):769-75.
2007: Honeywell R; Laan A C; van Groeningen C J; Strocchi E; Ruiter R; Giaccone G; Peters G J
The determination of gemcitabine and 2'-deoxycytidine in human plasma and tissue by APCI tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;847(2):142-52.
2007: Temmink O H; Hoebe E K; van der Born K; Ackland S P; Fukushima M; Peters G J
Mechanism of trifluorothymidine potentiation of oxaliplatin-induced cytotoxicity to colorectal cancer cells.
British journal of cancer 2007;96(2):231-40.
2007: Temmink O H; Prins H-J; van Gelderop E; Peters G J
The Hollow Fibre Assay as a model for in vivo pharmacodynamics of fluoropyrimidines in colon cancer cells.
British journal of cancer 2007;96(1):61-6.
2007: Temmink Olaf H; Hoebe Eveline K; Fukushima Masakazu; Peters Godefridus J
Irinotecan-induced cytotoxicity to colon cancer cells in vitro is stimulated by pre-incubation with trifluorothymidine.
European journal of cancer (Oxford, England : 1990) 2007;43(1):175-83.
2007: Bijnsdorp Irene V; Schwendener Reto A; Schott Herbert; Fichtner Iduna; Smid Kees; Schott Sarah; Laan Adrie C; Peters Godefridus J
In vivo and in vitro activity and mechanism of action of the multidrug cytarabine-L-glycerylyl-fluorodeoxyuridine.
Nucleosides, nucleotides & nucleic acids 2007;26(10-12):1619-24.
2007: Adema A D; Radi M; Daft J; Narayanasamy J; Hoebe E K; Alexander L E; Chu C K; Peters G J
Troxacitabine prodrugs for pancreatic cancer.
Nucleosides, nucleotides & nucleic acids 2007;26(8-9):1073-7.
2007: Temmink Olaf H; de Bruin Michiel; Turksma Annelies W; Cricca Silvia; Laan Adrie C; Peters Godefridus J
Activity and substrate specificity of pyrimidine phosphorylases and their role in fluoropyrimidine sensitivity in colon cancer cell lines.
The international journal of biochemistry & cell biology 2007;39(3):565-75.
2006: Haveman J; Sigmond J; van Bree C; Franken N A; Koedooder C; Peters G J
Time course of enhanced activity of deoxycytidine kinase and thymidine kinase 1 and 2 in cultured human squamous lung carcinoma cells, SW-1573, induced by gamma-irradiation.
Oncology reports 2006;16(4):901-5.
2006: Kroep J R; Smit E F; Giaccone G; Van der Born K; Beijnen J H; Van Groeningen C J; Van der Vijgh W J F; Postmus P E; Pinedo H M; Peters G J
Pharmacology of the paclitaxel-cisplatin, gemcitabine-cisplatin, and paclitaxel-gemcitabine combinations in patients with advanced non-small cell lung cancer.
Cancer chemotherapy and pharmacology 2006;58(4):509-16.
2006: Hooijberg J H; de Vries N A; Kaspers G J L; Pieters R; Jansen G; Peters G J
Multidrug resistance proteins and folate supplementation: therapeutic implications for antifolates and other classes of drugs in cancer treatment.
Cancer chemotherapy and pharmacology 2006;58(1):1-12.
2006: Padrón José M; Peters Godefridus J
Cytotoxicity of sphingoid marine compound analogs in mono- and multilayered solid tumor cell cultures.
Investigational new drugs 2006;24(3):195-202.
2006: Hubeek Isabelle; Peters Godefridus J; Broekhuizen Richard; Zwaan Christian M; Kaaijk Patricia; van Wering Elisabeth S; Gibson Brenda E S; Creutzig Ursula; Janka-Schaub Gritta E; den Boer Monique L; Pieters Rob; Kaspers Gertjan J L
In vitro sensitivity and cross-resistance to deoxynucleoside analogs in childhood acute leukemia.
Haematologica 2006;91(1):17-23.
2006: Peters Godefridus J; Van Moorsel Catharina J A; Lakerveld Bianca; Smid Kees; Noordhuis Paul; Comijn Elizabeth C; Weaver Dennis; Willey James C; Voorn Daphne; Van der Vijgh Wim J F; Pinedo Herbert M
Effects of gemcitabine on cis-platinum-DNA adduct formation and repair in a panel of gemcitabine and cisplatin-sensitive or -resistant human ovarian cancer cell lines.
International journal of oncology 2006;28(1):237-44.
2006: Smorenburg C H; Peters G J; van Groeningen C J; Noordhuis P; Smid K; van Riel A M G H; Dercksen W; Pinedo H M; Giaccone G
Phase II study of tailored chemotherapy for advanced colorectal cancer with either 5-fluouracil and leucovorin or oxaliplatin and irinotecan based on the expression of thymidylate synthase and dihydropyrimidine dehydrogenase.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2006;17(1):35-42.
2006: Temmink Olaf H; Hoogeland Marco F M; Fukushima Masakazu; Peters Godefridus J
Low folate conditions may enhance the interaction of trifluorothymidine with antifolates in colon cancer cells.
Cancer chemotherapy and pharmacology 2006;57(2):171-9.
2006: Honeywell R; van Groeningen C J; Laan A C; Strocchi E; Ruiter R; Giaccone G; Peters G J
Analysis of deoxycytidine accumulation in gemcitabine treated patients.
Nucleosides, nucleotides & nucleic acids 2006;25(9-11):1225-32.
2006: Sigmond J; Haveman J; Kreder N Castro; Loves W J; van Bree C; Franken N A; Peters G J
Enhanced activity of deoxycytidine kinase after pulsed low dose rate and single dose gamma irradiation.
Nucleosides, nucleotides & nucleic acids 2006;25(9-11):1177-80.
2006: Smid K; Bergman A M; Eijk P P; Veerman G; van Haperen V W T Ruiz; van den Ijssel P; Ylstra B; Peters G J
Micro-array analysis of resistance for gemcitabine results in increased expression of ribonucleotide reductase subunits.
Nucleosides, nucleotides & nucleic acids 2006;25(9-11):1001-7.
2006: Adema A D; Zuurbier L; Floor K; Hubeek I; Kaspers G J L; Albertoni F; Peters G J
Cellular resistance against troxacitabine in human cell lines and pediatric patient acute myeloid leukemia blast cells.
Nucleosides, nucleotides & nucleic acids 2006;25(9-11):981-6.
2006: Peters G J; Carrey E A; Sebesta I
Purine and pyrimidine metabolism: a firm basis for a transformed society.
Nucleosides, nucleotides & nucleic acids 2006;25(9-11):971-4.
2006: Temmink O H; de Bruin M; Laan A C; Turksma A W; Cricca S; Masterson A J; Noordhuis P; Peters G J
The role of thymidine phosphorylase and uridine phosphorylase in (fluoro)pyrimidine metabolism in peripheral blood mononuclear cells.
The international journal of biochemistry & cell biology 2006;38(10):1759-65.
2006: Pauwels Bea; Korst Annelies E C; Pattyn Greet G O; Lambrechts Hilde A J; Kamphuis Juliette A E; De Pooter Christel M J; Peters Godefridus J; Lardon Filip; Vermorken Jan B
The relation between deoxycytidine kinase activity and the radiosensitising effect of gemcitabine in eight different human tumour cell lines.
BMC cancer 2006;6():142.
2005: Hubeek I; Stam R W; Peters G J; Broekhuizen R; Meijerink J P P; van Wering E R; Gibson B E S; Creutzig U; Zwaan C M; Cloos J; Kuik D J; Pieters R; Kaspers G J L
The human equilibrative nucleoside transporter 1 mediates in vitro cytarabine sensitivity in childhood acute myeloid leukaemia.
British journal of cancer 2005;93(12):1388-94.
2005: de Lange S M; van der Born K; Kroep J R; Jensen H A; Pfeiffer P; Cleverly A; van Groeningen C J; Peters G J
No evidence of gemcitabine accumulation during weekly administration.
European journal of clinical pharmacology 2005;61(11):843-9.
2005: van de Wiel Mark A; Costa Jose L; Smid Kees; Oudejans Cees B M; Bergman Andries M; Meijer Gerrit A; Peters Godefridus J; Ylstra Bauke
Expression microarray analysis and oligo array comparative genomic hybridization of acquired gemcitabine resistance in mouse colon reveals selection for chromosomal aberrations.
Cancer research 2005;65(22):10208-13.
2005: Bergman Andries M; Eijk Paul P; Ruiz van Haperen Veronique W T; Smid Kees; Veerman Gijsbert; Hubeek Isabelle; van den Ijssel Paul; Ylstra Bauke; Peters Godefridus J
In vivo induction of resistance to gemcitabine results in increased expression of ribonucleotide reductase subunit M1 as the major determinant.
Cancer research 2005;65(20):9510-6.
2005: Hubeek I; Peters G J; Broekhuizen A J F; Sargent J; Gibson B E S; Creutzig U; Kaspers G J L
Potentiation of in vitro ara-C cytotoxicity by ribonucleotide reductase inhibitors, cyclin-dependent kinase modulators and the DNA repair inhibitor aphidicolin in paediatric acute myeloid leukaemia.
British journal of haematology 2005;131(2):219-22.
2005: Shafran Assaf; Ifergan Ilan; Bram Eran; Jansen Gerrit; Kathmann Ietje; Peters Godefridus J; Robey Robert W; Bates Susan E; Assaraf Yehuda G
ABCG2 harboring the Gly482 mutation confers high-level resistance to various hydrophilic antifolates.
Cancer research 2005;65(18):8414-22.
2005: Hubeek I; Peters G J; Broekhuizen A J F; Talianidis I; Sigmond J; Gibson B E S; Creutzig U; Giaccone G; Kaspers G J L
Immunocytochemical detection of deoxycytidine kinase in haematological malignancies and solid tumours.
Journal of clinical pathology 2005;58(7):695-9.
2005: de Jonge Robert; Hooijberg Jan Hendrik; van Zelst Bertrand D; Jansen Gerrit; van Zantwijk Christina H; Kaspers Gertjan J L; Peters Godefridus J; Ravindranath Yaddanapudi; Pieters Rob; Lindemans Jan
Effect of polymorphisms in folate-related genes on in vitro methotrexate sensitivity in pediatric acute lymphoblastic leukemia.
Blood 2005;106(2):717-20.
2005: Codacci-Pisanelli G; Pinedo H M; Lankelma J; Van Groeningen C J; Van Kuilenburg A B P; Van Gennip A H; Peters G J
Pharmacokinetics of bolus 5-fluorouracil: relationship between dose, plasma concentrations, area-under-the-curve and toxicity.
Journal of chemotherapy (Florence, Italy) 2005;17(3):315-20.
2005: Temmink Olaf H; de Bruin Michiel; Comijn Elizabeth M; Fukushima Masakazu; Peters Godefridus J
Determinants of trifluorothymidine sensitivity and metabolism in colon and lung cancer cells.
Anti-cancer drugs 2005;16(3):285-92.
2005: Sigmond Jennifer; Peters Godfridus J
Pyrimidine and purine analogues, effects on cell cycle regulation and the role of cell cycle inhibitors to enhance their cytotoxicity.
Nucleosides, nucleotides & nucleic acids 2005;24(10-12):1997-2022.
2004: Hubeek Isabelle; Litvinova Elena; Peters Godefridus J; Broekhuizen Richard; Haarman Eric G; Huismans Dieuwke R; Cloos Jacqueline; Zwaan Christian M; Fleischhack Gudrun; Creutzig Ursula; Kaspers Gertjan J L
The effect of G-CSF on the in vitro cytotoxicity of cytarabine and fludarabine in the FLAG combination in pediatric acute myeloid leukemia.
International journal of oncology 2004;25(6):1823-9.
2004: Fotoohi Kambiz; Jansen Gerrit; Assaraf Yehuda G; Rothem Lilah; Stark Michal; Kathmann Ietje; Gregorczyk Jacek; Peters Godefridus J; Albertioni Freidoun
Disparate mechanisms of antifolate resistance provoked by methotrexate and its metabolite 7-hydroxymethotrexate in leukemia cells: implications for efficacy of methotrexate therapy.
Blood 2004;104(13):4194-201.
2004: Peters G J; Smorenburg C H; Van Groeningen C J
Prospective clinical trials using a pharmacogenetic/pharmacogenomic approach.
Journal of chemotherapy (Florence, Italy) 2004;16 Suppl 4():25-30.
2004: Bergman A M; Kuiper C M; Myhren F; Sandvold M L; Hendriks H R; Peters G J
Antiproliferative activity and mechanism of action of fatty acid derivatives of arabinosylcytosine (ara-C) in leukemia and solid tumor cell lines.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1523-6.
2004: Hubeek I; Peters G J; Broekhuizen A J F; Kaspers G J L
Modulation of cytarabine induced cytotoxicity using novel deoxynucleoside analogs in the HL60 cell line.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1513-6.
2004: Sigmond J; Comijn E M; Kamphuis J A E; Peters G J
Combinations of 5-fluorouracil with UCN-01 or staurosporine.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1503-6.
2004: Temmink O H; Comijn E M; Fukushima M; Peters G J
Intracellular thymidylate synthase inhibition by trifluorothymidine in FM3A cells.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1491-4.
2004: de Bruin M; van Capel T; Smid K; van der Born K; Fukushima M; Hoekman K; Pinedo H M; Peters G J
Role of platelet derived endothelial cell growth factor/thymidine phosphorylase in fluoropyrimidine sensitivity and potential role of deoxyribose-1-phosphate.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1485-90.
2004: Noordhuis P; Holwerda U; Van Laar J A M; Van der Wilt C L; Peters G J
A non-radioactive sensitive assay to measure 5-fluorouracil incorporation into DNA of solid tumors.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1481-4.
2004: Mauritz R; Schwabe W; Haeusler P; Noordhuis P; Smid K; McLeod H L; Behnke D; van Groeningen C J; Peters G J
Comparison of mRNA expression levels determined with TaqMan and competitive template RT-PCR.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1471-4.
2004: Hooijberg J H; Peters G J; Kaspers G J L; Wielinga P R; Veerman A J P; Pieters R; Jansen G
Online fluorescent method to assess BCRP/ABCG2 activity in suspension cells.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1451-4.
2004: Mauritz R; Beumer I J; Marsh S; McLeod H L; Smid K; van Groeningen C J; Pinedo H M; Peters G J
Polymorphism of the thymidylate synthase gene and thymidylate synthase levels in colon cancer cell lines and different tissues of colorectal cancer patients.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1381-4.
2004: de Bruin M; Smid K; van der Ent M A; Fukushima M; Pinedo H M; Peters G J
Upregulation of platelet derived endothelial cell growth factor/thymidine phosphorylase by interferon alpha.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1367-70.
2004: Hubeek I; Peters G J; Broekhuizen A J F; Talianidis I; Schouten van Meeteren A Y N; van Wering E R; Gibson B; Creutzig U; Kaspers G J L
Immunocytochemical detection of deoxycytidine kinase in pediatric malignancies in relation to in vitro cytarabine sensitivity.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1351-6.
2004: Sigmond J; Loves W J; Kroep J R; Peters G J
Quantitative real time PCR of deoxycytidine kinase mRNA by Light Cycler PCR; in relation to enzyme activity.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1347-50.
2004: Bergman A M; Kuiper C M; Noordhuis P; Smid K; Voorn D A; Comijn E M; Myhren F; Sandvold M L; Hendriks H R; Fodstad O; Breistøl K; Peters G J
Antiproliferative activity and mechanism of action of fatty acid derivatives of gemcitabine in leukemia and solid tumor cell lines and in human xenografts.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1329-33.
2004: Peters G J; van Kuilenburg A B P; de Abreu R A
Purine and pyrimidine metabolism: new challenges.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1077-9.
2004: de Bruin Michiel; Peters Godefridus J; Oerlemans Ruud; Assaraf Yehuda G; Masterson Allan J; Adema Auke D; Dijkmans Ben A C; Pinedo Herbert M; Jansen Gerrit
Sulfasalazine down-regulates the expression of the angiogenic factors platelet-derived endothelial cell growth factor/thymidine phosphorylase and interleukin-8 in human monocytic-macrophage THP1 and U937 cells.
Molecular pharmacology 2004;66(4):1054-60.
2004: Sigmond Jennifer; Kroep Judith R; Loves Willem; Codacci-Pisanelli Giovanni; Peters Godefridus J
Quantitative real time PCR of deoxycytidine kinase mRNA by Light Cycler PCR in relation to enzyme activity and gemcitabine sensitivity.
Cancer letters 2004;213(2):173-9.
2004: Al-Madhoun Ashraf Said; van der Wilt Clasina L; Loves Willem J P; Padron Jose M; Eriksson Staffan; Talianidis Iannis; Peters Godefridus J
Detection of an alternatively spliced form of deoxycytidine kinase mRNA in the 2'-2'-difluorodeoxycytidine (gemcitabine)-resistant human ovarian cancer cell line AG6000.
Biochemical pharmacology 2004;68(4):601-9.
2004: Noordhuis P; Holwerda U; Van der Wilt C L; Van Groeningen C J; Smid K; Meijer S; Pinedo H M; Peters G J
5-Fluorouracil incorporation into RNA and DNA in relation to thymidylate synthase inhibition of human colorectal cancers.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2004;15(7):1025-32.
2004: Haveman J; Castro Kreder N; Rodermond H M; van Bree C; Franken N A P; Stalpers L J A; Zdzienicka M Z; Peters G J
Cellular response of X-ray sensitive hamster mutant cell lines to gemcitabine, cisplatin and 5-fluorouracil.
Oncology reports 2004;12(1):187-92.
2004: Peters Godefridus J; Noordhuis Paul; Van Groeningen Cornelis J; Giaccone Giuseppe; Holwerda Ulbe; Voorn Daphne; Schrijvers Ad; Schornagel Jan H; Beijnen Jos H; Fumoleau Pierre; Schellens Jan H M
The effect of food on the pharmacokinetics of S-1 after single oral administration to patients with solid tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(12 Pt 1):4072-6.
2004: De Bruin Michiel; Van Capel Toni; Smid Kees; Fukushima Masakazu; Hoekman Klaas; Pinedo Herbert M; Peters Godefridus J
The effect of fluoropyrimidines with or without thymidine phosphorylase inhibitor on the expression of thymidine phosphorylase.
European journal of pharmacology 2004;491(2-3):93-9.
2004: Giaccone G; González-Larriba J L; van Oosterom A T; Alfonso R; Smit E F; Martens M; Peters G J; van der Vijgh W J F; Smith R; Averbuch S; Fandi A
Combination therapy with gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, gemcitabine and cisplatin in patients with advanced solid tumors.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2004;15(5):831-8.
2004: Ossenkoppele Gert J; Graveland Wilfried J; Sonneveld Pieter; Daenen Simon M G J; Biesma Douwe H; Verdonck Leo F; Schaafsma M Ron; Westveer Petra H M; Peters Godefridus J; Noordhuis Paul; Muus Petra; Selleslag Dominik; van der Holt Bronnie; Delforge Michel; Löwenberg Bob; Verhoef Gregor E G;
The value of fludarabine in addition to ARA-C and G-CSF in the treatment of patients with high-risk myelodysplastic syndromes and AML in elderly patients.
Blood 2004;103(8):2908-13.
2004: Hooijberg Jan Hendrik; Jansen Gerrit; Assaraf Yehuda G; Kathmann Ietje; Pieters Rob; Laan Adrie C; Veerman Anjo J P; Kaspers Gertjan J L; Peters Godefridus J
Folate concentration dependent transport activity of the Multidrug Resistance Protein 1 (ABCC1).
Biochemical pharmacology 2004;67(8):1541-8.
2004: De Berardinis E; Antonini G; Peters G J; Loves W J; Van der Born K; Codacci-Pisanelli G; Di Silverio F
Intravesical administration of gemcitabine in superficial bladder cancer: a phase I study with pharmacodynamic evaluation.
BJU international 2004;93(4):491-4.
2004: De Lange S M; van Groeningen C J; Kroep J R; Van Bochove A; Snijders J F; Peters G J; Pinedo H M; Giaccone G
Phase II trial of cisplatin and gemcitabine in patients with advanced gastric cancer.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2004;15(3):484-8.
2004: Bergman A M; Kuiper C M; Voorn D A; Comijn E M; Myhren F; Sandvold M L; Hendriks H R; Peters G J
Antiproliferative activity and mechanism of action of fatty acid derivatives of arabinofuranosylcytosine in leukemia and solid tumor cell lines.
Biochemical pharmacology 2004;67(3):503-11.
2004: Kroep J R; Pinedo H M; Giaccone G; Van Bochove A; Peters G J; Van Groeningen C J
Phase II study of cisplatin preceding gemcitabine in patients with advanced oesophageal cancer.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2004;15(2):230-5.
2003: Sargent Jean M; Williamson Christine J; Hubeek Isabelle; Elgie Alena W; Taylor Colin G; Den Boer Monique L; Peters Godefridus J; Kaspers Gertjan L
Aphidicolin decreases ex vivo resistance to cytosine arabinoside in childhood acute leukaemia.
Oncology reports 2003;10(6):2027-31.
2003: Wang Ling-Zhi; Goh Boon-Cher; Lee How-Sung; Noordhuis Paul; Peters Godefridus J
An expedient assay for determination of gemcitabine and its metabolite in human plasma using isocratic ion-pair reversed-phase high-performance liquid chromatography.
Therapeutic drug monitoring 2003;25(5):552-7.
2003: Kroep Judith R; Van Groeningen Cornelis J; Cuesta Miguel A; Craanen Mike E; Hoekstra Otto S; Comans Emile F I; Bloemena Elisabeth; Hoekstra Corneline J; Golding Richard P; Twisk Jos W R; Peters Godefridus J; Pinedo Herbert M; Lammertsma Adriaan A
Positron emission tomography using 2-deoxy-2-[18F]-fluoro-D-glucose for response monitoring in locally advanced gastroesophageal cancer; a comparison of different analytical methods.
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 2003;5(5):337-46.
2003: Sigmond Jennifer; Backus Harold H J; Wouters Dorine; Temmink Olaf H; Jansen Gerrit; Peters Godefridus J
Induction of resistance to the multitargeted antifolate Pemetrexed (ALIMTA) in WiDr human colon cancer cells is associated with thymidylate synthase overexpression.
Biochemical pharmacology 2003;66(3):431-8.
2003: Peters G J; Noordhuis P; Van Kuilenburg A B P; Schornagel J H; Gall H; Turner S L; Swart M S; Voorn D; Van Gennip A H; Wanders J; Holwerda U; Smid K; Giaccone G; Fumoleau P; Van Groeningen C J
Pharmacokinetics of S-1, an oral formulation of ftorafur, oxonic acid and 5-chloro-2,4-dihydroxypyridine (molar ratio 1:0.4:1) in patients with solid tumors.
Cancer chemotherapy and pharmacology 2003;52(1):1-12.
2003: Bergman A M; Pinedo H M; Talianidis I; Veerman G; Loves W J P; van der Wilt C L; Peters G J
Increased sensitivity to gemcitabine of P-glycoprotein and multidrug resistance-associated protein-overexpressing human cancer cell lines.
British journal of cancer 2003;88(12):1963-70.
2003: Backus H H J; Wouters D; Ferreira C G; van Houten V M M; Brakenhoff R H; Pinedo H M; Peters G J
Thymidylate synthase inhibition triggers apoptosis via caspases-8 and -9 in both wild-type and mutant p53 colon cancer cell lines.
European journal of cancer (Oxford, England : 1990) 2003;39(9):1310-7.
2003: Wosikowski Katja; Biedermann Elfi; Rattel Benno; Breiter Norbert; Jank Peter; Löser Roland; Jansen Gerrit; Peters Godefridus J
In vitro and in vivo antitumor activity of methotrexate conjugated to human serum albumin in human cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(5):1917-26.
2003: de Bruin M; van Capel T; Van der Born K; Kruyt F A; Fukushima M; Hoekman K; Pinedo H M; Peters G J
Role of platelet-derived endothelial cell growth factor/thymidine phosphorylase in fluoropyrimidine sensitivity.
British journal of cancer 2003;88(6):957-64.
2003: van der Wilt C L; Kroep J R; Loves W J P; Rots M G; Van Groeningen C J; Kaspers G J; Peters G J
Expression of deoxycytidine kinase in leukaemic cells compared with solid tumour cell lines, liver metastases and normal liver.
European journal of cancer (Oxford, England : 1990) 2003;39(5):691-7.
2003: Hooijberg Jan Hendrik; Peters Godefridus J; Assaraf Yehuda G; Kathmann Ietje; Priest David G; Bunni Marlene A; Veerman Anjo J P; Scheffer George L; Kaspers Gertjan J L; Jansen Gerrit
The role of multidrug resistance proteins MRP1, MRP2 and MRP3 in cellular folate homeostasis.
Biochemical pharmacology 2003;65(5):765-71.
2003: de Bruin M; Smid K; Laan A C; Noordhuis P; Fukushima M; Hoekman K; Pinedo H M; Peters G J
Rapid disappearance of deoxyribose-1-phosphate in platelet derived endothelial cell growth factor/thymidine phosphorylase overexpressing cells.
Biochemical and biophysical research communications 2003;301(3):675-9.
2003: Assaraf Yehuda G; Rothem Lilah; Hooijberg Jan Hendrik; Stark Michal; Ifergan Ilan; Kathmann Ietje; Dijkmans Ben A C; Peters Godefridus J; Jansen Gerrit
Loss of multidrug resistance protein 1 expression and folate efflux activity results in a highly concentrative folate transport in human leukemia cells.
The Journal of biological chemistry 2003;278(9):6680-6.
2003: Stam Ronald W; den Boer Monique L; Meijerink Jules P P; Ebus Marli E G; Peters Godefridus J; Noordhuis Paul; Janka-Schaub Gritta E; Armstrong Scott A; Korsmeyer Stanley J; Pieters Rob
Differential mRNA expression of Ara-C-metabolizing enzymes explains Ara-C sensitivity in MLL gene-rearranged infant acute lymphoblastic leukemia.
Blood 2003;101(4):1270-6.
2003: Van Moorsel C J A; Smid K; Voorn D A; Bergman A M; Pinedo H M; Peters G J
Effect of gemcitabine and cis-platinum combinations on ribonucleotide and deoxyribonucleotide pools in ovarian cancer cell lines.
International journal of oncology 2003;22(1):201-7.
2003: Ackland Stephen P; Beale Phillip; Peters Godefridus J
Thymidylate synthase inhibitors.
Cancer chemotherapy and biological response modifiers 2003;21():1-28.
2002: van Bree Chris; Castro Kreder Natasja; Loves Willem J P; Franken Nicolaas A P; Peters Godefridus J; Haveman Jaap
Sensitivity to ionizing radiation and chemotherapeutic agents in gemcitabine-resistant human tumor cell lines.
International journal of radiation oncology, biology, physics 2002;54(1):237-44.
2002: van der Wilt Clasina L; Smid Kees; Peters Godefridus J
Effects of antifolates on the binding of 5-fluoro-2'-deoxyuridine monophosphate to thymidylate synthase.
Biochemical pharmacology 2002;64(4):669-75.
2002: Gröschel Bettina; Kaufmann Andreas; Höver Gerold; Cinatl Jaroslav; Doerr Hans Wilhelm; Noordhuis Paul; Loves Willem J P; Peters Godefridus J; Cinatl Jindrich
3'-Azido-2',3'-dideoxythymidine induced deficiency of thymidine kinases 1, 2 and deoxycytidine kinase in H9 T-lymphoid cells.
Biochemical pharmacology 2002;64(2):239-46.
2002: Peters G J; Backus H H J; Freemantle S; van Triest B; Codacci-Pisanelli G; van der Wilt C L; Smid K; Lunec J; Calvert A H; Marsh S; McLeod H L; Bloemena E; Meijer S; Jansen G; van Groeningen C J; Pinedo H M
Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism.
Biochimica et biophysica acta 2002;1587(2-3):194-205.
2002: de Lange S M; van Groeningen C J; Meijer O W M; Cuesta M A; Langendijk J A; van Riel J M G H; Pinedo H M; Peters G J; Meijer S; Slotman B J; Giaccone G
Gemcitabine-radiotherapy in patients with locally advanced pancreatic cancer.
European journal of cancer (Oxford, England : 1990) 2002;38(9):1212-7.
2002: Ramakers-van Woerden N L; Pieters R; Rots M G; van Zantwijk C H; Noordhuis P; Beverloo H B; Peters G J; van Wering E R; Camitta B M; Pui C-H; Relling M V; Evans W E; Veerman A J P
Infants with acute lymphoblastic leukemia: no evidence for high methotrexate resistance.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2002;16(5):949-51.
2002: Kroep Judith R; Loves Willem J P; van der Wilt Clasina L; Alvarez Enrique; Talianidis Iannis; Boven Epie; Braakhuis Boudewijn J M; van Groeningen Cornelis J; Pinedo Herbert M; Peters Godefridus J
Pretreatment deoxycytidine kinase levels predict in vivo gemcitabine sensitivity.
Molecular cancer therapeutics 2002;1(6):371-6.
2002: Kuenen Bart C; Rosen Lee; Smit Egbert F; Parson Mandy R N; Levi Marcel; Ruijter Rita; Huisman Holger; Kedde Marc A; Noordhuis Paul; van der Vijgh Wim J F; Peters Godefridus J; Cropp Gillian F; Scigalla Paul; Hoekman Klaus; Pinedo Herbert M; Giaccone Giuseppe
Dose-finding and pharmacokinetic study of cisplatin, gemcitabine, and SU5416 in patients with solid tumors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2002;20(6):1657-67.
2002: Backus H H J; Van Groeningen C J; Vos W; Dukers D F; Bloemena E; Wouters D; Pinedo H M; Peters G J
Differential expression of cell cycle and apoptosis related proteins in colorectal mucosa, primary colon tumours, and liver metastases.
Journal of clinical pathology 2002;55(3):206-11.
2002: Bergman Andries M; Pinedo Herbert M; Peters Godefridus J
Determinants of resistance to 2',2'-difluorodeoxycytidine (gemcitabine).
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2002;5(1):19-33.
2002: Mauritz Robert; Peters Godefridus J; Priest David G; Assaraf Yehuda G; Drori Stavit; Kathmann Ietje; Noordhuis Paul; Bunni Marlene A; Rosowsky Andre; Schornagel Jan H; Pinedo Herbert M; Jansen Gerrit
Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemia cells and their implications for folate homeostasis.
Biochemical pharmacology 2002;63(2):105-15.
2002: Zwaan Christian M; Kaspers Gertjan J L; Pieters Rob; Hählen Karel; Janka-Schaub Gritta E; van Zantwijk Christina H; Huismans Dieuwke R; de Vries Esther; Rots Marianne G; Peters Godefridus J; Jansen Gerrit; Creutzig Ursula; Veerman Anjo J P
Different drug sensitivity profiles of acute myeloid and lymphoblastic leukemia and normal peripheral blood mononuclear cells in children with and without Down syndrome.
Blood 2002;99(1):245-51.
2002: Kreder Natasja Castro; van Bree Chris; Peters Godefridus J; Loves Willem J P; Haveman Jaap
Enhanced levels of deoxycytidine kinase and thymidine kinase 1 and 2 after pulsed low dose rate irradiation as an adaptive response to radiation.
Oncology reports 2002;9(1):141-4.
2002: Ackland Stephen P; Clarke Stephen J; Beale Phillip; Peters Godefridus J
Thymidylate synthase inhibitors.
Cancer chemotherapy and biological response modifiers 2002;20():1-36.
2002: Codacci-Pisanelli Giovanni; Van der Wilt Clasina L; Smid Kees; Noordhuis Paul; Voorn Daphne; Pinedo Herbert M; Peters Godefridus J
High-dose 5-Fluorouracil with uridine-diphosphoglucose rescue increases thymidylate synthase inhibition but not 5-Fluorouracil incorporation into RNA in murine tumors.
Oncology 2002;62(4):363-70.
2001: Backus H H; Rustum Y M; van Groeningen C J; Peters G J
Chemotherapeutic strategies for treatment of colorectal cancer: present and future developments.
Clinical colorectal cancer 2001;1(2):121-7.
2001: Van Kuilenburg A B; Stroomer A E; Peters G J; Van Gennip A H
Simultaneous determination of F-beta-alanine and beta-alanine in plasma and urine with dual-column reversed-phase high-performance liquid chromatography.
Journal of chromatography. B, Biomedical sciences and applications 2001;759(1):51-61.
2001: Smid K; Van Moorsel C J; Noordhuis P; Voorn D A; Peters G J
Interference of gemcitabine triphosphate with the measurements of deoxynucleotides using an optimized DNA polymerase elongation assay.
International journal of oncology 2001;19(1):157-62.
2001: Backus H H; van Riel J M; van Groeningen C J; Vos W; Dukers D F; Bloemena E; Wouters D; Pinedo H M; Peters G J
Rb, mcl-1 and p53 expression correlate with clinical outcome in patients with liver metastases from colorectal cancer.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2001;12(6):779-85.
2001: Bergman A M; Munch-Petersen B; Jensen P B; Sehested M; Veerman G; Voorn D A; Smid K; Pinedo H M; Peters G J
Collateral sensitivity to gemcitabine (2',2'-difluorodeoxycytidine) and cytosine arabinoside of daunorubicin- and VM-26-resistant variants of human small cell lung cancer cell lines.
Biochemical pharmacology 2001;61(11):1401-8.
2001: van der Wilt C L; Backus H H; Smid K; Comijn L; Veerman G; Wouters D; Voorn D A; Priest D G; Bunni M A; Mitchell F; Jackman A L; Jansen G; Peters G J
Modulation of both endogenous folates and thymidine enhance the therapeutic efficacy of thymidylate synthase inhibitors.
Cancer research 2001;61(9):3675-81.
2001: Bergman A M; Pinedo H M; Peters G J
Steroids affect collateral sensitivity to gemcitabine of multidrug-resistant human lung cancer cells.
European journal of pharmacology 2001;416(1-2):19-24.
2001: Rots M G; Pieters R; Jansen G; Kaspers G J; Van Zantwijk C H; Noordhuis P; Voorn D A; Van Wering E R; Creutzig U; Veerman A J; Peters G J
A possible role for methotrexate in the treatment of childhood acute myeloid leukaemia, in particular for acute monocytic leukaemia.
European journal of cancer (Oxford, England : 1990) 2001;37(4):492-8.
2001: Backus H H; Dukers D F; van Groeningen C J; Vos W; Bloemena E; Wouters D; van Riel J M; Smid K; Giaccone G; Pinedo H M; Peters G J
5-Fluorouracil induced Fas upregulation associated with apoptosis in liver metastases of colorectal cancer patients.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2001;12(2):209-16.
2000: Rots M G; Willey J C; Jansen G; Van Zantwijk C H; Noordhuis P; DeMuth J P; Kuiper E; Veerman A J; Pieters R; Peters G J
mRNA expression levels of methotrexate resistance-related proteins in childhood leukemia as determined by a standardized competitive template-based RT-PCR method.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2000;14(12):2166-75.
2000: Ferreira C G; Span S W; Peters G J; Kruyt F A; Giaccone G
Chemotherapy triggers apoptosis in a caspase-8-dependent and mitochondria-controlled manner in the non-small cell lung cancer cell line NCI-H460.
Cancer research 2000;60(24):7133-41.
2000: van Moorsel C J; Pinedo H M; Smid K; Comijn E M; Voorn D A; Veerman G; Lakerveld B; Van der Vijgh W J; Giaccone G; Postmus P E; Peters G J
Schedule-dependent pharmacodynamic effects of gemcitabine and cisplatin in mice bearing Lewis lung murine non-small cell lung tumours.
European journal of cancer (Oxford, England : 1990) 2000;36(18):2420-9.
2000: Padrón J M; van der Wilt C L; Smid K; Smitskamp-Wilms E; Backus H H; Pizao P E; Giaccone G; Peters G J
The multilayered postconfluent cell culture as a model for drug screening.
Critical reviews in oncology/hematology 2000;36(2-3):141-57.
2000: Bergman A M; Giaccone G; van Moorsel C J; Mauritz R; Noordhuis P; Pinedo H M; Peters G J
Cross-resistance in the 2',2'-difluorodeoxycytidine (gemcitabine)-resistant human ovarian cancer cell line AG6000 to standard and investigational drugs.
European journal of cancer (Oxford, England : 1990) 2000;36(15):1974-83.
2000: Kroep J R; Giaccone G; Tolis C; Voorn D A; Loves W J; Groeningen C J; Pinedo H M; Peters G J
Sequence dependent effect of paclitaxel on gemcitabine metabolism in relation to cell cycle and cytotoxicity in non-small-cell lung cancer cell lines.
British journal of cancer 2000;83(8):1069-76.
2000: Drori S; Jansen G; Mauritz R; Peters G J; Assaraf Y G
Clustering of mutations in the first transmembrane domain of the human reduced folate carrier in GW1843U89-resistant leukemia cells with impaired antifolate transport and augmented folate uptake.
The Journal of biological chemistry 2000;275(40):30855-63.
2000: Rots M G; Pieters R; Kaspers G J; Veerman A J; Peters G J; Jansen G
Classification of ex vivo methotrexate resistance in acute lymphoblastic and myeloid leukaemia.
British journal of haematology 2000;110(4):791-800.
2000: van Muiswinkel F L; Riemers F M; Peters G J; LaFleur M V; Siegel D; Jongenelen C A; Drukarch B
L-Dopa stimulates expression of the antioxidant enzyme NAD(P)H:quinone oxidoreductase (NQO) in cultured astroglial cells.
Free radical biology & medicine 2000;29(5):442-53.
2000: Backus H H; Pinedo H M; Wouters D; Padrón J M; Molders N; van Der Wilt C L; van Groeningen C J; Jansen G; Peters G J
Folate depletion increases sensitivity of solid tumor cell lines to 5-fluorouracil and antifolates.
International journal of cancer. Journal international du cancer 2000;87(6):771-8.
2000: Peters G J; van der Wilt C L; van Moorsel C J; Kroep J R; Bergman A M; Ackland S P
Basis for effective combination cancer chemotherapy with antimetabolites.
Pharmacology & therapeutics 2000;87(2-3):227-53.
2000: van Groeningen C J; Peters G J; Schornagel J H; Gall H; Noordhuis P; de Vries M J; Turner S L; Swart M S; Pinedo H M; Hanauske A R; Giaccone G
Phase I clinical and pharmacokinetic study of oral S-1 in patients with advanced solid tumors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2000;18(14):2772-9.
2000: Rots M G; Pieters R; Peters G J; Noordhuis P; Van Zantwijk C H; Henze G; Janka-Schaub G E; Veerman A J; Jansen G
Methotrexate resistance in relapsed childhood acute lymphoblastic leukaemia.
British journal of haematology 2000;109(3):629-34.
2000: Van Triest B; Loftus B M; Pinedo H M; Backus H H; Schoenmakers P; Telleman F; Tadema T; Aherne G W; Van Groeningen C J; Zoetmulder F A; Taal B G; Johnston P G; Peters G J
Thymidylate synthase expression in patients with colorectal carcinoma using a polyclonal thymidylate synthase antibody in comparison to the TS 106 monoclonal antibody.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2000;48(6):755-60.
2000: Peters G J; van Triest B; Backus H H; Kuiper C M; van der Wilt C L; Pinedo H M
Molecular downstream events and induction of thymidylate synthase in mutant and wild-type p53 colon cancer cell lines after treatment with 5-fluorouracil and the thymidylate synthase inhibitor raltitrexed.
European journal of cancer (Oxford, England : 1990) 2000;36(7):916-24.
2000: Van Triest B; Pinedo H M; Giaccone G; Peters G J
Downstream molecular determinants of response to 5-fluorouracil and antifolate thymidylate synthase inhibitors.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2000;11(4):385-91.
2000: van Triest B; Pinedo H M; Blaauwgeers J L; van Diest P J; Schoenmakers P S; Voorn D A; Smid K; Hoekman K; Hoitsma H F; Peters G J
Prognostic role of thymidylate synthase, thymidine phosphorylase/platelet-derived endothelial cell growth factor, and proliferation markers in colorectal cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(3):1063-72.
2000: van Moorsel C J; Bergman A M; Veerman G; Voorn D A; Ruiz van Haperen V W; Kroep J R; Pinedo H M; Peters G J
Differential effects of gemcitabine on ribonucleotide pools of twenty-one solid tumour and leukaemia cell lines.
Biochimica et biophysica acta 2000;1474(1):5-12.
2000: Ferreira C G; Tolis C; Span S W; Peters G J; van Lopik T; Kummer A J; Pinedo H M; Giaccone G
Drug-induced apoptosis in lung cnacer cells is not mediated by the Fas/FasL (CD95/APO1) signaling pathway.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(1):203-12.
2000: Backus H H; Wouters D; van der Wilt C L; Kuiper C M; van Groeningen C J; Pinedo H M; Peters G J
Thymidylate synthase inhibition induces p53 dependent and independent cell death.
Advances in experimental medicine and biology 2000;486():303-6.
2000: Peters G J; De Bruin M; Fukushima M; Van Triest B; Hoekman K; Pinedo H M; Ackland S P
Thymidine phosphorylase in angiogenesis and drug resistance. Homology with platelet-derived endothelial cell growth factor.
Advances in experimental medicine and biology 2000;486():291-4.
2000: van der Wilt C L; Kroep J R; Bergman A M; Loves W J; Alvarez E; Talianidis I; Eriksson S; van Groeningen C J; Pinedo H M; Peters G J
The role of deoxycytidine kinase in gemcitabine cytotoxicity.
Advances in experimental medicine and biology 2000;486():287-90.
2000: Backus H H; Pinedo H M; Wouters D; Kuiper C M; Jansen G; van Groeningen C J; Peters G J
Differences in the induction of DNA damage, cell cycle arrest, and cell death by 5-fluorouracil and antifolates.
Oncology research 2000;12(5):231-9.
1999: Kroep J R; Peters G J; van Moorsel C J; Catik A; Vermorken J B; Pinedo H M; van Groeningen C J
Gemcitabine-cisplatin: a schedule finding study.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1999;10(12):1503-10.
1999: Jansen G; Peters G J; Pinedo H M; Priest D G; Assaraf Y G
Re: Folylpolyglutamyl synthetase gene transfer and glioma antifolate sensitivity in culture and in vivo.
Journal of the National Cancer Institute 1999;91(23):2047-50.
1999: Rots M G; Pieters R; Peters G J; van Zantwijk C H; Mauritz R; Noordhuis P; Willey J C; Hählen K; Creutzig U; Janka-Schaub G; Kaspers G J; Veerman A J; Jansen G
Circumvention of methotrexate resistance in childhood leukemia subtypes by rationally designed antifolates.
Blood 1999;94(9):3121-8.
1999: Peters G J; Smitskamp-Wilms E; Smid K; Pinedo H M; Jansen G
Determinants of activity of the antifolate thymidylate synthase inhibitors Tomudex (ZD1694) and GW1843U89 against mono- and multilayered colon cancer cell lines under folate-restricted conditions.
Cancer research 1999;59(21):5529-35.
1999: Van Triest B; Peters G J
Thymidylate synthase: a target for combination therapy and determinant of chemotherapeutic response in colorectal cancer.
Oncology 1999;57(3):179-94.
1999: Kroep J R; Giaccone G; Voorn D A; Smit E F; Beijnen J H; Rosing H; van Moorsel C J; van Groeningen C J; Postmus P E; Pinedo H M; Peters G J
Gemcitabine and paclitaxel: pharmacokinetic and pharmacodynamic interactions in patients with non-small-cell lung cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1999;17(7):2190-7.
1999: Padrón J M; van Moorsel C J; Bergman A M; Smitskamp-Wilms E; van der Wilt C L; Peters G J
Selective cell kill of the combination of gemcitabine and cisplatin in multilayered postconfluent tumor cell cultures.
Anti-cancer drugs 1999;10(5):445-52.
1999: Hooijberg J H; Broxterman H J; Kool M; Assaraf Y G; Peters G J; Noordhuis P; Scheper R J; Borst P; Pinedo H M; Jansen G
Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2.
Cancer research 1999;59(11):2532-5.
1999: van Moorsel C J; Pinedo H M; Veerman G; Bergman A M; Kuiper C M; Vermorken J B; van der Vijgh W J; Peters G J
Mechanisms of synergism between cisplatin and gemcitabine in ovarian and non-small-cell lung cancer cell lines.
British journal of cancer 1999;80(7):981-90.
1999: Kool M; van der Linden M; de Haas M; Scheffer G L; de Vree J M; Smith A J; Jansen G; Peters G J; Ponne N; Scheper R J; Elferink R P; Baas F; Borst P
MRP3, an organic anion transporter able to transport anti-cancer drugs.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(12):6914-9.
1999: van Moorsel C J; Pinedo H M; Veerman G; Vermorken J B; Postmus P E; Peters G J
Scheduling of gemcitabine and cisplatin in Lewis lung tumour bearing mice.
European journal of cancer (Oxford, England : 1990) 1999;35(5):808-14.
1999: Tolis C; Peters G J; Ferreira C G; Pinedo H M; Giaccone G
Cell cycle disturbances and apoptosis induced by topotecan and gemcitabine on human lung cancer cell lines.
European journal of cancer (Oxford, England : 1990) 1999;35(5):796-807.
1999: Bergman A M; Cristalli G; Vittori S; Wang J; Eriksson S; Peters G J
Biological activity of 1-deazapurine nucleosides: role of deoxycytidine kinase?
Nucleosides & nucleotides 1999;18(4-5):897-8.
1999: Peters G J; Voorn D A; Kuiper C M; van der Wilt C L; Noordhuis P; Smid K; Myhren F; Sandvold M; Hendriks H R
Cell specific cytotoxicity and structure-activity relationship of lipophilic 1-B-D-arabinofuranosylcytosine (ara-C) derivatives.
Nucleosides & nucleotides 1999;18(4-5):877-8.
1999: van Moorsel C J; Kroep J R; Pinedo H M; Veerman G; Voorn D A; Postmus P E; Vermorken J B; van Groeningen C J; van der Vijgh W J; Peters G J
Pharmacokinetic schedule finding study of the combination of gemcitabine and cisplatin in patients with solid tumors.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1999;10(4):441-8.
1999: Jansen G; Barr H; Kathmann I; Bunni M A; Priest D G; Noordhuis P; Peters G J; Assaraf Y G
Multiple mechanisms of resistance to polyglutamatable and lipophilic antifolates in mammalian cells: role of increased folylpolyglutamylation, expanded folate pools, and intralysosomal drug sequestration.
Molecular pharmacology 1999;55(4):761-9.
1999: van Triest B; Pinedo H M; van Hensbergen Y; Smid K; Telleman F; Schoenmakers P S; van der Wilt C L; van Laar J A; Noordhuis P; Jansen G; Peters G J
Thymidylate synthase level as the main predictive parameter for sensitivity to 5-fluorouracil, but not for folate-based thymidylate synthase inhibitors, in 13 nonselected colon cancer cell lines.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(3):643-54.
1999: Rots M G; Pieters R; Peters G J; Noordhuis P; van Zantwijk C H; Kaspers G J; Hählen K; Creutzig U; Veerman A J; Jansen G
Role of folylpolyglutamate synthetase and folylpolyglutamate hydrolase in methotrexate accumulation and polyglutamylation in childhood leukemia.
Blood 1999;93(5):1677-83.
1999: van Moorsel C J; Pinedo H M; Veerman G; Guechev A; Smid K; Loves W J; Vermorken J B; Postmus P E; Peters G J
Combination chemotherapy studies with gemcitabine and etoposide in non-small cell lung and ovarian cancer cell lines.
Biochemical pharmacology 1999;57(4):407-15.
1999: Bergman A M; Pinedo H M; Jongsma A P; Brouwer M; Ruiz van Haperen V W; Veerman G; Leyva A; Eriksson S; Peters G J
Decreased resistance to gemcitabine (2',2'-difluorodeoxycitidine) of cytosine arabinoside-resistant myeloblastic murine and rat leukemia cell lines: role of altered activity and substrate specificity of deoxycytidine kinase.
Biochemical pharmacology 1999;57(4):397-406.
1999: Rots M G; Pieters R; Kaspers G J; van Zantwijk C H; Noordhuis P; Mauritz R; Veerman A J; Jansen G; Peters G J
Differential methotrexate resistance in childhood T- versus common/preB-acute lymphoblastic leukemia can be measured by an in situ thymidylate synthase inhibition assay, but not by the MTT assay.
Blood 1999;93(3):1067-74.
1999: van der Wilt C L; Kuiper C M; Peters G J
Combination studies of antifolates with 5-fluorouracil in colon cancer cell lines.
Oncology research 1999;11(8):383-91.
1999: Kroep J R; Pinedo H M; van Groeningen C J; Peters G J
Experimental drugs and drug combinations in pancreatic cancer.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1999;10 Suppl 4():234-8.
1998: Jansen G; Mauritz R; Drori S; Sprecher H; Kathmann I; Bunni M; Priest D G; Noordhuis P; Schornagel J H; Pinedo H M; Peters G J; Assaraf Y G
A structurally altered human reduced folate carrier with increased folic acid transport mediates a novel mechanism of antifolate resistance.
The Journal of biological chemistry 1998;273(46):30189-98.
1998: Mauritz R; Bekkenk M W; Rots M G; Pieters R; Mini E; van Zantwijk C H; Veerman A J; Peters G J; Jansen G
Ex vivo activity of methotrexate versus novel antifolate inhibitors of dihydrofolate reductase and thymidylate synthase against childhood leukemia cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(10):2399-410.
1998: Smitskamp-Wilms E; Pinedo H M; Veerman G; Ruiz van Haperen V W; Peters G J
Postconfluent multilayered cell line cultures for selective screening of gemcitabine.
European journal of cancer (Oxford, England : 1990) 1998;34(6):921-6.
1998: Freund A; Boos J; Harkin S; Schultze-Mosgau M; Veerman G; Peters G J; Gescher A
Augmentation of 1-beta-D-arabinofuranosylcytosine (Ara-C) cytotoxicity in leukaemia cells by co-administration with antisignalling drugs.
European journal of cancer (Oxford, England : 1990) 1998;34(6):895-901.
1998: Elgie A W; Sargent J M; Alton P; Peters G J; Noordhuis P; Williamson C J; Taylor C G
Modulation of resistance to ara-C by bryostatin in fresh blast cells from patients with AML.
Leukemia research 1998;22(4):373-8.
1998: van Laar J A; Rustum Y M; Ackland S P; van Groeningen C J; Peters G J
Comparison of 5-fluoro-2'-deoxyuridine with 5-fluorouracil and their role in the treatment of colorectal cancer.
European journal of cancer (Oxford, England : 1990) 1998;34(3):296-306.
1998: Van Kuilenburg A B; Poorter R L; Peters G J; Van Gennip A H; Van Lenthe H; Stroomer A E; Smid K; Noordhuis P; Bakker P J; Veenhof C H
No circadian variation of dihydropyrimidine dehydrogenase, uridine phosphorylase, beta-alanine, and 5-fluorouracil during continuous infusion of 5-fluorouracil.
Advances in experimental medicine and biology 1998;431():811-6.
1998: Peters G J; Kuiper C M; van Triest B; Backus H; van der Wilt C L; van Laar J A; Jansen G; van Groeningen C J; Pinedo H M
Determinants of the therapeutic efficacy of thymidylate synthase inhibitors.
Advances in experimental medicine and biology 1998;431():699-704.
1998: van Moorsel C J; Veerman G; Ruiz van Haperen V W; Bergman A M; Jensen P B; Sehested M; Peters G J
Differential effects of gemcitabine on nucleotide pools of 19 solid tumor cell lines.
Advances in experimental medicine and biology 1998;431():661-5.
1998: Kroep J R; van Moorsel C J; Veerman G; Voorn D A; Schultz R M; Worzalla J F; Tanzer L R; Merriman R L; Pinedo H M; Peters G J
Role of deoxycytidine kinase (dCK), thymidine kinase 2 (TK2), and deoxycytidine deaminase (dCDA) in the antitumor activity of gemcitabine (dFdC).
Advances in experimental medicine and biology 1998;431():657-60.
1998: van der Wilt C L; Smid K; Veerman G; Peters G J
The role of thymidine kinase activity in murine colon tumours treated with 5-fluorouracil.
Advances in experimental medicine and biology 1998;431():653-6.
1998: Ruiz van Haperen V W; Veerman G; van Moorsel C J; Peters G J
Induction of in vivo resistance against gemcitabine (dFdC, 2',2'-difluoro-deoxycytidine).
Advances in experimental medicine and biology 1998;431():637-40.
1998: Peters G J; van Groeningen C J; Pinedo H M
Dihydropyrimidine dehydrogenase in livers from mouse and rat, and in human liver, colon tumors, and mucosa in relation to anabolism of 5-fluorouracil.
Advances in experimental medicine and biology 1998;431():633-6.
1998: Bergman A M; Pinedo H M; Veerman G; Kuiper C M; Peters G J
Increased sensitivity to gemcitabine of P-gP and MRP overexpressing human non-small cell lung cancer cell lines.
Advances in experimental medicine and biology 1998;431():591-4.
1998: Bergman A M; Pinedo H M; Ruiz van Haperen V W; Veerman G; Kuiper C M; Peters G J
Cross-resistance of the gemcitabine resistant human ovarian cancer cell line AG6000 to standard and investigational drugs.
Advances in experimental medicine and biology 1998;431():587-90.
1998: van Moorsel C J; Veerman G; Vermorken J B; Voorn D A; Kroep J R; Bergman A M; Pinedo H M; Peters G J
Mechanisms of synergism between gemcitabine and cisplatin.
Advances in experimental medicine and biology 1998;431():581-5.
1997: van Triest B; Pinedo H M; Telleman F; van der Wilt C L; Jansen G; Peters G J
Cross-resistance to antifolates in multidrug resistant cell lines with P-glycoprotein or multidrug resistance protein expression.
Biochemical pharmacology 1997;53(12):1855-66.
1997: van Moorsel C J; Veerman G; Bergman A M; Guechev A; Vermorken J B; Postmus P E; Peters G J
Combination chemotherapy studies with gemcitabine.
Seminars in oncology 1997;24(2 Suppl 7):S7-17-S7-23.
1997: Codacci-Pisanelli G; Kralovanszky J; van der Wilt C L; Noordhuis P; Colofiore J R; Martin D S; Franchi F; Peters G J
Modulation of 5-fluorouracil in mice using uridine diphosphoglucose.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(2):309-15.
1997: Langeveld C H; Jongenelen C A; Theeuwes J W; Baak J P; Heimans J J; Stoof J C; Peters G J
The antiproliferative effect of 8-chloro-adenosine, an active metabolite of 8-chloro-cyclic adenosine monophosphate, and disturbances in nucleic acid synthesis and cell cycle kinetics.
Biochemical pharmacology 1997;53(2):141-8.
1997: van der Wilt C L; van Groeningen C J; Pinedo H M; Smid K; Hoekman K; Meijer S; Peters G J
5-fluorouracil/leucovorin-induced inhibition of thymidylate synthase in normal tissues of mouse and man.
Journal of cancer research and clinical oncology 1997;123(11-12):595-601.
1997: Jansen G; Mauritz R M; Assaraf Y G; Sprecher H; Drori S; Kathmann I; Westerhof G R; Priest D G; Bunni M; Pinedo H M; Schornagel J H; Peters G J
Regulation of carrier-mediated transport of folates and antifolates in methotrexate-sensitive and-resistant leukemia cells.
Advances in enzyme regulation 1997;37():59-76.
1996: Peters G J; Ruiz van Haperen V W; Bergman A M; Veerman G; Smitskamp-Wilms E; van Moorsel C J; Kuiper C M; Braakhuis B J
Preclinical combination therapy with gemcitabine and mechanisms of resistance.
Seminars in oncology 1996;23(5 Suppl 10):16-24.
1996: van Laar J A; van der Wilt C L; Rustum Y M; Noordhuis P; Smid K; Pinedo H M; Peters G J
Therapeutic efficacy of fluoropyrimidines depends on the duration of thymidylate synthase inhibition in the murine colon 26-B carcinoma tumor model.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(8):1327-33.
1996: Visser G W; van der Wilt C L; Wedzinga R; Peters G J; Herscheid J D
18F-radiopharmacokinetics of [18F]-5-fluorouracil in a mouse bearing two colon tumors with a different 5-fluorouracil sensitivity: a study for a correlation with oncological results.
Nuclear medicine and biology 1996;23(3):333-42.
1996: Smitskamp-Wilms E; Hendriks H R; Peters G J
Development, pharmacology, role of DT-diaphorase and prospects of the indoloquinone EO9.
General pharmacology 1996;27(3):421-9.
1996: Bergman A M; Ruiz van Haperen V W; Veerman G; Kuiper C M; Peters G J
Synergistic interaction between cisplatin and gemcitabine in vitro.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(3):521-30.
1996: Noordhuis P; Kazemier K M; Kasperrs G J; Peters G J
Modulation of metabolism and cytotoxicity of cytosine arabinoside with N-(phosphon)-acetyl-L-aspartate in human leukemic blast cells and cell lines.
Leukemia research 1996;20(2):127-34.
1996: Van Laar J A; Rustum Y M; Van der Wilt C L; Smid K; Kuiper C M; Pinedo H M; Peters G J
Tumor size and origin determine the antitumor activity of cisplatin or 5-fluorouracil and its modulation by leucovorin in murine colon carcinomas.
Cancer chemotherapy and pharmacology 1996;39(1-2):79-89.
1996: Veerman G; Ruiz van Haperen V W; Vermorken J B; Noordhuis P; Braakhuis B J; Pinedo H M; Peters G J
Antitumor activity of prolonged as compared with bolus administration of 2',2'-difluorodeoxycytidine in vivo against murine colon tumors.
Cancer chemotherapy and pharmacology 1996;38(4):335-42.
1995: Braakhuis B J; Ruiz van Haperen V W; Welters M J; Peters G J
Schedule-dependent therapeutic efficacy of the combination of gemcitabine and cisplatin in head and neck cancer xenografts.
European journal of cancer (Oxford, England : 1990) 1995;31A(13-14):2335-40.
1995: Peters G J; van der Wilt C L
Thymidylate synthase as a target in cancer chemotherapy.
Biochemical Society transactions 1995;23(4):884-8.
1995: Peters G J; Noordhuis P; Komissarov A; Holwerda U; Kok M; Van Laar J A; Van der Wilt C L; Van Groeningen V; Pinedo H M
Quantification of 5-fluorouracil incorporation into RNA of human and murine tumors as measured with a sensitive gas chromatography-mass spectrometry assay.
Analytical biochemistry 1995;231(1):157-63.
1995: Smitskamp-Wilms E; Giaccone G; Pinedo H M; van der Laan B F; Peters G J
DT-diaphorase activity in normal and neoplastic human tissues; an indicator for sensitivity to bioreductive agents?
British journal of cancer 1995;72(4):917-21.
1995: Westerhof G R; Rijnboutt S; Schornagel J H; Pinedo H M; Peters G J; Jansen G
Functional activity of the reduced folate carrier in KB, MA104, and IGROV-I cells expressing folate-binding protein.
Cancer research 1995;55(17):3795-802.
1995: Westerhof G R; Schornagel J H; Kathmann I; Jackman A L; Rosowsky A; Forsch R A; Hynes J B; Boyle F T; Peters G J; Pinedo H M
Carrier- and receptor-mediated transport of folate antagonists targeting folate-dependent enzymes: correlates of molecular-structure and biological activity.
Molecular pharmacology 1995;48(3):459-71.
1995: Peters G J; Bergman A M; Ruiz van Haperen V W; Veerman G; Kuiper C M; Braakhuis B J
Interaction between cisplatin and gemcitabine in vitro and in vivo.
Seminars in oncology 1995;22(4 Suppl 11):72-9.
1995: Braakhuis B J; Ruiz van Haperen V W; Boven E; Veerman G; Peters G J
Schedule-dependent antitumor effect of gemcitabine in in vivo model system.
Seminars in oncology 1995;22(4 Suppl 11):42-6.
1995: Ruiz van Haperen V W; Veerman G; Eriksson S; Stegmann A P; Peters G J
Induction of resistance to 2',2'-difluorodeoxycytidine in the human ovarian cancer cell line A2780.
Seminars in oncology 1995;22(4 Suppl 11):35-41.
1995: Peters G J; van der Wilt C L; van Triest B; Codacci-Pisanelli G; Johnston P G; van Groeningen C J; Pinedo H M
Thymidylate synthase and drug resistance.
European journal of cancer (Oxford, England : 1990) 1995;31A(7-8):1299-305.
1995: Van der Wilt C L; Braakhuis B J; Pinedo H M; De Jong M; Smid K; Peters G J
Addition of leucovorin in modulation of 5-fluorouracil with methotrexate: potentiating or reversing effect?
International journal of cancer. Journal international du cancer 1995;61(5):672-8.
1995: van der Wilt C L; Cloos J; de Jong M; Pinedo H M; Peters G J
Screening of colon tumor cells and tissues for folylpolyglutamate synthetase activity.
Oncology research 1995;7(6):317-21.
1995: van der Wilt C L; Marinelli A; Pinedo H M; Cloos J; Smid K; van de Velde C J; Peters G J
The effect of different routes of administration of 5-fluorouracil on thymidylate synthase inhibition in the rat.
European journal of cancer (Oxford, England : 1990) 1995;31A(5):754-60.
1995: Peters G J; van der Vijgh W J
Protection of normal tissues from the cytotoxic effects of chemotherapy and radiation by amifostine (WR-2721): preclinical aspects.
European journal of cancer (Oxford, England : 1990) 1995;31A Suppl 1():S1-7.
1995: Codacci-Pisanelli G; van der Wilt C L; Pinedo H M; Franchi F; Noordhuis P; Braakhuis B J; van Laar J A; Peters G J
Antitumour activity, toxicity and inhibition of thymidylate synthase of prolonged administration of 5-fluorouracil in mice.
European journal of cancer (Oxford, England : 1990) 1995;31A(9):1517-25.
1995: Poorter R L; Peters G J; Bakker P J; Taat C W; Biermans-van Leeuwe D M; Codacci-Pisanelli G; Noordhuis P; Oosting J; Veenhof C H
Intermittent continuous infusion of 5-fluorouracil and low dose oral leucovorin in patients with gastrointestinal cancer: relationship between plasma concentrations and clinical parameters.
European journal of cancer (Oxford, England : 1990) 1995;31A(9):1465-70.
1994: van der Vijgh W J; Peters G J
Protection of normal tissues from the cytotoxic effects of chemotherapy and radiation by amifostine (Ethyol): preclinical aspects.
Seminars in oncology 1994;21(5 Suppl 11):2-7.
1994: Ruiz van Haperen V W; Veerman G; Boven E; Noordhuis P; Vermorken J B; Peters G J
Schedule dependence of sensitivity to 2',2'-difluorodeoxycytidine (Gemcitabine) in relation to accumulation and retention of its triphosphate in solid tumour cell lines and solid tumours.
Biochemical pharmacology 1994;48(7):1327-39.
1994: Pizao P E; Smitskamp-Wilms E; Van Ark-Otte J; Beijnen J H; Peters G J; Pinedo H M; Giaccone G
Antiproliferative activity of the topoisomerase I inhibitors topotecan and camptothecin, on sub- and postconfluent tumor cell cultures.
Biochemical pharmacology 1994;48(6):1145-54.
1994: Ruiz van Haperen V W; Veerman G; Eriksson S; Boven E; Stegmann A P; Hermsen M; Vermorken J B; Pinedo H M; Peters G J
Development and molecular characterization of a 2',2'-difluorodeoxycytidine-resistant variant of the human ovarian carcinoma cell line A2780.
Cancer research 1994;54(15):4138-43.
1994: Lopez-Lopez R; Langeveld C H; Pizao P E; van Rijswijk R E; Wagstaff J; Pinedo H M; Peters G J
Effect of suramin on adenylate cyclase and protein kinase C.
Anti-cancer drug design 1994;9(4):279-90.
1994: Ruiz van Haperen V W; Peters G J
New targets for pyrimidine antimetabolites for the treatment of solid tumours. 2: Deoxycytidine kinase.
Pharmacy world & science : PWS 1994;16(2):104-12.
1994: van der Wilt C L; Peters G J
New targets for pyrimidine antimetabolites in the treatment of solid tumours. 1: Thymidylate synthase.
Pharmacy world & science : PWS 1994;16(2):84-103.
1994: Smitskamp-Wilms E; Peters G J; Pinedo H M; van Ark-Otte J; Giaccone G
Chemosensitivity to the indoloquinone EO9 is correlated with DT-diaphorase activity and its gene expression.
Biochemical pharmacology 1994;47(8):1325-32.
1994: De Graaf T W; Peters G J; van Dijk W
Antimetabolite-induced increases in the invasive capacity of murine leukaemia L1210 cells.
Clinical & experimental metastasis 1994;12(2):134-42.
1994: Treskes M; Boven E; van de Loosdrecht A A; Wijffels J F; Cloos J; Peters G J; Pinedo H M; van der Vijgh W J
Effects of the modulating agent WR2721 on myelotoxicity and antitumour activity in carboplatin-treated mice.
European journal of cancer (Oxford, England : 1990) 1994;30A(2):183-7.
1994: Lopez R; Peters G J; Smitskamp-Wilms E; Virizuela J A; van Ark-Otte J; Pinedo H M; Giaccone G
In vitro sequence-dependent synergistic effect of suramin and camptothecin.
European journal of cancer (Oxford, England : 1990) 1994;30A(11):1670-4.
1994: Lopez Lopez R; van Rijswijk R E; Wagstaff J; Pinedo H M; Peters G J
The synergistic and antagonistic effects of cytotoxic and biological agents on the in vitro antitumour effects of suramin.
European journal of cancer (Oxford, England : 1990) 1994;30A(10):1545-9.
1994: Peters G J; van der Wilt C L; van Groeningen C J
Predictive value of thymidylate synthase and dihydropyrimidine dehydrogenase.
European journal of cancer (Oxford, England : 1990) 1994;30A(10):1408-11.
1994: Peters G J
Therapy related disturbances in nucleotides in cancer cells.
Advances in experimental medicine and biology 1994;370():95-107.
1994: van Oostveen D C; Pieters R; Peters G J; Veerman A J
Purine nucleotide interconversion enzymes in childhood leukemia: relation with cell cycle and clinical outcome.
Advances in experimental medicine and biology 1994;370():209-12.
1994: van Triest B; Telleman F; Pinedo H M; van der Wilt C L; Peters G J
Cross-resistance to thymidylate synthase inhibitors in P-glycoprotein and non-P-glycoprotein cell lines.
Advances in experimental medicine and biology 1994;370():189-93.
1994: Bergman A M; Ruiz van Haperen V W; Veerman G; Kuiper C M; Peters G J
Synergistic interaction between cisplatin and gemcitabine in ovarian and colon cancer cell lines.
Advances in experimental medicine and biology 1994;370():139-43.
1994: van der Wilt C L; van Laar J A; Smid K; Rustum Y M; Peters G J
Comparison of 5-fluoro-2'-deoxyuridine and 5-fluorouracil in the treatment of murine colon cancer; effects on thymidylate synthase.
Advances in experimental medicine and biology 1994;370():109-14.
1993: Braakhuis B J; Jansen G; Noordhuis P; Kegel A; Peters G J
Importance of pharmacodynamics in the in vitro antiproliferative activity of the antifolates methotrexate and 10-ethyl-10-deazaaminopterin against human head and neck squamous cell carcinoma.
Biochemical pharmacology 1993;46(12):2155-61.
1993: van der Wilt C L; Visser G W; Braakhuis B J; Wedzinga R; Noordhuis P; Smid K; Peters G J
In vitro antitumour activity of cis- and trans-5-fluoro-5,6-dihydro-6-alkoxy-uracils; effects on thymidylate synthesis.
British journal of cancer 1993;68(4):702-7.
1993: Edzes H T; Peters G J; Noordhuis P; Vermorken J B
Determination of the antimetabolite Gemcitabine (2',2'-difluoro-2'-deoxycytidine) and of 2',2'-difluoro-2'-deoxyuridine by 19F nuclear magnetic resonance spectroscopy.
Analytical biochemistry 1993;214(1):25-30.
1993: Ruiz van Haperen V W; Veerman G; Vermorken J B; Peters G J
2',2'-Difluoro-deoxycytidine (gemcitabine) incorporation into RNA and DNA of tumour cell lines.
Biochemical pharmacology 1993;46(4):762-6.
1993: Peters G J; Laurensse E; Steinbusch H W; De Vente J; Smid K; Van der Wilt C L; Pinedo H M
Development, characterization and application of an antibody against 5-fluoro-2'deoxyuridine-5'monophosphate, the active metabolite of 5-fluorouracil.
Anticancer research 1993;13(4):835-9.
1993: Peters G J; Wets M; Keepers Y P; Oskam R; van Ark-Otte J; Noordhuis P; Smid K; Pinedo H M
Transformation of mouse fibroblasts with the oncogenes H-ras OR trk is associated with pronounced changes in drug sensitivity and metabolism.
International journal of cancer. Journal international du cancer 1993;54(3):450-5.
1993: van Groeningen C J; Peters G J; Pinedo H M
Reversal of 5-fluorouracil-induced toxicity by oral administration of uridine.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1993;4(4):317-20.
1993: Peters G J; Rustum Y M
Novel approaches to selective treatments of human solid tumors: laboratory and clinical correlation.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1993;4(4):277-81.
1993: van der Wilt C L; Pinedo H M; de Jong M; Peters G J
Effect of folate diastereoisomers on the binding of 5-fluoro-2'-deoxyuridine-5'-monophosphate to thymidylate synthase.
Biochemical pharmacology 1993;45(5):1177-9.
1993: Peters G J; Lankelma J; Kok R M; Noordhuis P; van Groeningen C J; van der Wilt C L; Meyer S; Pinedo H M
Prolonged retention of high concentrations of 5-fluorouracil in human and murine tumors as compared with plasma.
Cancer chemotherapy and pharmacology 1993;31(4):269-76.
1993: De Graaf T W; Slot S S; Peters G J; Van Dijk W
Changes in glycosylation of L1210 cells after exposure to various antimetabolites.
European journal of cancer (Oxford, England : 1990) 1993;29A(12):1760-5.
1993: Peters G J; van der Wilt C L; Cloos J; Pinedo H M
Development of a simple folylpolyglutamate synthetase assay in tissues and cell lines.
Advances in experimental medicine and biology 1993;338():651-4.
1993: Peters G J; Hoekman K; van Groeningen C J; van der Wilt C L; Smid K; Meijer S; Pinedo H M
Potentiation of 5-fluorouracil induced inhibition of thymidylate synthase in human colon tumors by leucovorin is dose dependent.
Advances in experimental medicine and biology 1993;338():613-6.
1993: van der Wilt C L; de Jong M; Braakhuis B J; Pinedo H M; Peters G J
The interval between methotrexate and leucovorin determines the efficacy of 5-fluorouracil modulation in vitro and in vivo.
Advances in experimental medicine and biology 1993;338():609-12.
1993: Ruiz van Haperen V W; Veerman G; Braakhuis B J; Vermorken J B; Boven E; Leyva A; Peters G J
Deoxycytidine kinase and deoxycytidine deaminase activities in human tumour xenografts.
European journal of cancer (Oxford, England : 1990) 1993;29A(15):2132-7.
1993: Pizao P E; Peters G J; Van Ark-Otte J; Smets L A; Smitskamp-Wilms E; Winograd B; Pinedo H M; Giaccone G
Cytotoxic effects of anticancer agents on subconfluent and multilayered postconfluent cultures.
European journal of cancer (Oxford, England : 1990) 1993;29A(11):1566-73.
1993: Peters G J; Codacci-Pisanelli G; van der Wilt C L; van Laar J A; Smid K; Noordhuis P; Pinedo H M
Comparison of continuous infusions and bolus injections of 5-fluorouracil with or without leucovorin: implications for inhibition of thymidylate synthase.
Advances in experimental medicine and biology 1993;339():9-20; discussion 21.
1993: Peters G J; Schornagel J H; Milano G A
Clinical pharmacokinetics of anti-metabolites.
Cancer surveys 1993;17():123-56.
1993: Van der Wilt C L; Smid K; Aherne G W; Pinedo H M; Peters G J
Evaluation of immunohistochemical staining and activity of thymidylate synthase in cell lines.
Advances in experimental medicine and biology 1993;338():605-8.
1992: Pizao P E; Lyaruu D M; Peters G J; van Ark-Otte J; Winograd B; Giaccone G; Pinedo H M
Growth, morphology and chemosensitivity studies on postconfluent cells cultured in 'V'-bottomed microtiter plates.
British journal of cancer 1992;66(4):660-5.
1992: Van der Wilt C L; Pinedo H M; Smid K; Peters G J
Elevation of thymidylate synthase following 5-fluorouracil treatment is prevented by the addition of leucovorin in murine colon tumors.
Cancer research 1992;52(18):4922-8.
1992: Pieters R; Huismans D R; Loonen A H; Peters G J; Hählen K; van der Does-van den Berg A; van Wering E R; Veerman A J
Relation of 5'-nucleotidase and phosphatase activities with immunophenotype, drug resistance and clinical prognosis in childhood leukemia.
Leukemia research 1992;16(9):873-80.
1992: Lopez Lopez R; Peters G J; van Loenen A C; Pizao P E; van Rijswijk R E; Wagstaff J; Pinedo H M
The effect of schedule, protein binding and growth factors on the activity of suramin.
International journal of cancer. Journal international du cancer 1992;51(6):921-6.
1992: Pizao P E; Winograd B; Peters G J; Leyva A; Giaccone G; Pinedo H M
In vitro chemosensitivity testing of multilayered microcultures.
Anticancer research 1992;12(4):1319-22.
1992: Pieters R; Huismans D R; Loonen A H; Peters G J; Hählen K; van der Does-van den Berg A; van Wering E R; Veerman A J
Adenosine deaminase and purine nucleoside phosphorylase in childhood lymphoblastic leukemia: relation with differentiation stage, in vitro drug resistance and clinical prognosis.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1992;6(5):375-80.
1992: Pieters R; Huismans D R; Loonen A H; Peters G J; Hählen K; van der Does-van den Berg A; van Wering E R; Veerman A J
Hypoxanthine-guanine phosphoribosyl-transferase in childhood leukemia: relation with immunophenotype, in vitro drug resistance and clinical prognosis.
International journal of cancer. Journal international du cancer 1992;51(2):213-7.
1992: Peters G J; van Groeningen C J; van der Wilt C L; Meijer S; Smid K; Laurensse E; Pinedo H M
Time course of inhibition of thymidylate synthase in patients treated with fluorouracil and leucovorin.
Seminars in oncology 1992;19(2 Suppl 3):26-35.
1992: van Groeningen C J; Peters G J; Pinedo H M
Modulation of fluorouracil toxicity with uridine.
Seminars in oncology 1992;19(2 Suppl 3):148-54.
1992: van der Wilt C L; Pinedo H M; Smid K; Cloos J; Noordhuis P; Peters G J
Effect of folinic acid on fluorouracil activity and expression of thymidylate synthase.
Seminars in oncology 1992;19(2 Suppl 3):16-25.
1992: Peters G J; Kraal I; Pinedo H M
In vitro and in vivo studies on the combination of Brequinar sodium (DUP-785; NSC 368390) with 5-fluorouracil; effects of uridine.
British journal of cancer 1992;65(2):229-33.
1992: van Laar J A; van der Wilt C L; Treskes M; van der Vijgh W J; Peters G J
Effect of WR-2721 on the toxicity and antitumor activity of the combination of carboplatin and 5-fluorouracil.
Cancer chemotherapy and pharmacology 1992;31(2):97-102.
1992: van der Wilt C L; van Laar J A; Gyergyay F; Smid K; Peters G J
Biochemical modification of the toxicity and the anti-tumour effect of 5-fluorouracil and cis-platinum by WR-2721 in mice.
European journal of cancer (Oxford, England : 1990) 1992;28A(12):2017-24.
1992: Peters G J; van der Wilt C L; Gyergyay F; van Laar J A; Treskes M; van der Vijgh W J; Pinedo H M
Protection by WR-2721 of the toxicity induced by the combination of cisplatin and 5-fluorouracil.
International journal of radiation oncology, biology, physics 1992;22(4):785-9.
1991: Peters G J; van Groeningen C J; Laurensse E J; Pinedo H M
A comparison of 5-fluorouracil metabolism in human colorectal cancer and colon mucosa.
Cancer 1991;68(9):1903-9.
1991: Pieters R; Thompson L F; Broekema G J; Huismans D R; Peters G J; Pals S T; Horst E; Hählen K; Veerman A J
Expression of 5'-nucleotidase (CD73) related to other differentiation antigens in leukemias of B-cell lineage.
Blood 1991;78(2):488-92.
1991: Peters G J; van Groeningen C J
Clinical relevance of biochemical modulation of 5-fluorouracil.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1991;2(7):469-80.
1991: van Groeningen C J; Peters G J; Nadal J C; Laurensse E; Pinedo H M
Clinical and pharmacologic study of orally administered uridine.
Journal of the National Cancer Institute 1991;83(6):437-41.
1991: Spoelstra E C; Pinedo H M; Dekker H; Peters G J; Lankelma J
Measurement of in vitro cellular pharmacokinetics of 5-fluorouracil in human and rat cancer cell lines and rat hepatocytes using a flow-through system.
Cancer chemotherapy and pharmacology 1991;27(4):320-5.
1991: Keepers Y P; Pizao P E; Peters G J; van Ark-Otte J; Winograd B; Pinedo H M
Comparison of the sulforhodamine B protein and tetrazolium (MTT) assays for in vitro chemosensitivity testing.
European journal of cancer (Oxford, England : 1990) 1991;27(7):897-900.
1991: Peters G J; van Groeningen C J; Laurensse E J; Pinedo H M
Thymidylate synthase from untreated human colorectal cancer and colonic mucosa: enzyme activity and inhibition by 5-fluoro-2'-deoxy-uridine-5'-monophosphate.
European journal of cancer (Oxford, England : 1990) 1991;27(3):263-7.
1991: Braakhuis B J; Visser G W; Stringer I; Peters G J
In vitro antiproliferative and metabolic activity of eight novel 5-fluorinated uracil nucleosides.
European journal of cancer (Oxford, England : 1990) 1991;27(3):250-3.
1991: Ruiz van Haperen V W; Veerman G; Noordhuis P; Vermorken J B; Peters G J
Concentration and time dependent growth inhibition and metabolism in vitro by 2',2'-difluoro-deoxycytidine (gemcitabine).
Advances in experimental medicine and biology 1991;309A():57-60.
1991: Peters G J; van Groeningen C J; van der Wilt C L; Smid K; Meijer S; Pinedo H M
Effect of leucovorin on 5-fluorouracil induced inhibition of thymidylate synthase in patients with colon cancer.
Advances in experimental medicine and biology 1991;309A():131-4.
1991: Van der Wilt C L; Marinelli A; Cloos J; Smid K; Pinedo H M; Peters G J
Isolated liver perfusion versus hepatic artery infusion with 5-fluorouracil in a rat model; effects on thymidylate synthase.
Advances in experimental medicine and biology 1991;309A():105-8.
1990: Peters G J; Schwartsmann G; Nadal J C; Laurensse E J; van Groeningen C J; van der Vijgh W J; Pinedo H M
In vivo inhibition of the pyrimidine de novo enzyme dihydroorotic acid dehydrogenase by brequinar sodium (DUP-785; NSC 368390) in mice and patients.
Cancer research 1990;50(15):4644-9.
1990: Peters G J; Pinedo H M; Ferwerda W; de Graaf T W; van Dijk W
Do antimetabolites interfere with the glycosylation of cellular glycoconjugates?
European journal of cancer (Oxford, England : 1990) 1990;26(4):516-23.
1990: Braakhuis B J; van Dongen G A; Peters G J; van Walsum M; Snow G B
Antitumor activity of brequinar sodium (Dup-785) against human head and neck squamous cell carcinoma xenografts.
Cancer letters 1990;49(2):133-7.
1990: Peters G J; Nadal J C; Laurensse E J; de Kant E; Pinedo H M
Retention of in vivo antipyrimidine effects of Brequinar sodium (DUP-785; NSC 368390) in murine liver, bone marrow and colon cancer.
Biochemical pharmacology 1990;39(1):135-44.
1990: Visser G W; Gorree G C; Peters G J; Herscheid J D
Tissue distribution of [18F]-5-fluorouracil in mice: effects of route of administration, strain, tumour and dose.
Cancer chemotherapy and pharmacology 1990;26(3):205-9.
1989: Nadal J C; van Groeningen C J; Pinedo H M; Peters G J
Schedule-dependency of in vivo modulation of 5-fluorouracil by leucovorin and uridine in murine colon carcinoma.
Investigational new drugs 1989;7(2-3):163-72.
1989: de Kant E; Pinedo H M; Laurensse E; Peters G J
The relation between inhibition of cell growth and of dihydroorotic acid dehydrogenase by brequinar sodium.
Cancer letters 1989;46(2):123-7.
1989: Peters G J; Braakhuis B J; de Bruijn E A; Laurensse E J; van Walsum M; Pinedo H M
Enhanced therapeutic efficacy of 5'deoxy-5-fluorouridine in 5-fluorouracil resistant head and neck tumours in relation to 5-fluorouracil metabolising enzymes.
British journal of cancer 1989;59(3):327-34.
1989: van Groeningen C J; Peters G J; Leyva A; Laurensse E; Pinedo H M
Reversal of 5-fluorouracil-induced myelosuppression by prolonged administration of high-dose uridine.
Journal of the National Cancer Institute 1989;81(2):157-62.
1989: van Groeningen C J; Peters G J; Pinedo H M
Lack of effectiveness of combined 5-fluorouracil and leucovorin in patients with 5-fluorouracil-resistant advanced colorectal cancer.
European journal of cancer & clinical oncology 1989;25(1):45-9.
1989: Peters G J; Laurensse E J; van Groeningen C J; Meijer S; Pinedo H M
In vitro and in vivo inhibition of thymidylate synthase of human colon cancer by 5-fluorouracil.
Advances in experimental medicine and biology 1989;253A():439-45.
1989: Pels Rijcken W R; Telleman F; Peters G J; Ferwerda W
Incorporation of 5-fluorouracil into nucleotide sugars and the effect on glycoconjugates in rat hepatoma cells and hepatocytes.
Advances in experimental medicine and biology 1989;253B():313-20.
1989: Peters G J; Laurensse E; de Kant E; Nadal J C; Pinedo H M
The relationship between dihydroorotic acid dehydrogenase and in vitro and in vivo cytostatic effects of brequinar sodium (DUP-785; NSC 368390).
Advances in experimental medicine and biology 1989;253B():375-82.
1989: Laurensse E J; Braakhuis B J; Pinedo H M; Peters G J
Fluoropyrimidine metabolism in human head and neck cancer xenografts and murine colon tumors.
Advances in experimental medicine and biology 1989;253B():327-34.
1988: van Groeningen C J; Pinedo H M; Heddes J; Kok R M; de Jong A P; Wattel E; Peters G J; Lankelma J
Pharmacokinetics of 5-fluorouracil assessed with a sensitive mass spectrometric method in patients on a dose escalation schedule.
Cancer research 1988;48(23):6956-61.
1988: Laurensse E J; Pinedo H M; Peters G J
A sensitive non-radioactive assay for pyrimidine nucleoside phosphorylase using reversed-phase high performance liquid chromatography.
Clinica chimica acta; international journal of clinical chemistry 1988;178(1):71-8.
1988: Schwartsmann G; Peters G J; Laurensse E; de Waal F C; Loonen A H; Leyva A; Pinedo H M
DUP 785 (NSC 368390): schedule-dependency of growth-inhibitory and antipyrimidine effects.
Biochemical pharmacology 1988;37(17):3257-66.
1988: Peters G J; van Dijk J; Laurensse E; van Groeningen C J; Lankelma J; Leyva A; Nadal J C; Pinedo H M
In vitro biochemical and in vivo biological studies of the uridine 'rescue' of 5-fluorouracil.
British journal of cancer 1988;57(3):259-65.
1988: Nadal J C; Van Groeningen C J; Pinedo H M; Peters G J
In vivo potentiation of 5-fluorouracil by leucovorin in murine colon carcinoma.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 1988;42(6):387-93.
1987: Peters G J; Laurensse E; Leyva A; Pinedo H M
Purine nucleosides as cell-specific modulators of 5-fluorouracil metabolism and cytotoxicity.
European journal of cancer & clinical oncology 1987;23(12):1869-81.
1987: Peters G J; van Groeningen C J; Laurensse E; Kraal I; Leyva A; Lankelma J; Pinedo H M
Effect of pyrimidine nucleosides on body temperatures of man and rabbit in relation to pharmacokinetic data.
Pharmaceutical research 1987;4(2):113-9.
1987: Peters G J; Van Dijk J; Nadal J C; Van Groeningen C J; Lankelma J; Pinedo H M
Diurnal variation in the therapeutic efficacy of 5-fluorouracil against murine colon cancer.
In vivo (Athens, Greece) 1987;1(2):113-7.
1987: Peters G J; van Groeningen C J; Laurensse E J; Lankelma J; Leyva A; Pinedo H M
Uridine-induced hypothermia in mice and rats in relation to plasma and tissue levels of uridine and its metabolites.
Cancer chemotherapy and pharmacology 1987;20(2):101-8.
1986: van Groeningen C J; Leyva A; Kraal I; Peters G J; Pinedo H M
Clinical and pharmacokinetic studies of prolonged administration of high-dose uridine intended for rescue from 5-FU toxicity.
Cancer treatment reports 1986;70(6):745-50.
1986: Peters G J; van Dijk J; van Groeningen C; Laurensse E J; Leyva A; Lankelma J; Pinedo H M
Toxicity and antitumor effect of 5-fluorouracil and its rescue by uridine.
Advances in experimental medicine and biology 1986;195 Pt B():121-8.
1985: Kok R M; de Jong A P; van Groeningen C J; Peters G J; Lankelma J
Highly sensitive determination of 5-fluorouracil in human plasma by capillary gas chromatography and negative ion chemical ionization mass spectrometry.
Journal of chromatography 1985;343(1):59-66.
1984: Leyva A; van Groeningen C J; Kraal I; Gall H; Peters G J; Lankelma J; Pinedo H M
Phase I and pharmacokinetic studies of high-dose uridine intended for rescue from 5-fluorouracil toxicity.
Cancer research 1984;44(12 Pt 1):5928-33.
1984: Peters G J; Kraal I; Laurensse E; Leyva A; Pinedo H M
Separation of 5-fluorouracil and uracil by ion-pair reversed-phase high-performance liquid chromatography on a column with porous polymeric packing.
Journal of chromatography 1984;307(2):464-8.

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