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Godefridus Peters

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L H A M de Wilt; G Jansen; J Kroon; S de Jong; Godefridus J Peters; Frank A E Kruyt
Bortezomib and TRAIL: a perfect match for apoptotic elimination of tumour cells?
Hans M Westgeest; Ronald Hoekstra; Richard J Honeywell; Godefridus J Peters; Nielka P van Erp; Hendrik Verheul
Successful treatment of renal cell carcinoma with sorafenib after effective but hepatotoxic sunitinib exposure.
Mina Maftouh; Godefridus J Peters; Amir Avan; Elena Galvani; Elisa Giovannetti
Molecular Mechanisms Underlying the Role of MicroRNAs in Resistance to Epidermal Growth Factor Receptor-Targeted Agents and Novel Therapeutic Strategies for Treatment of Non-Small-Cell Lung Cancer.

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2013: L H A M de Wilt; G Jansen; J Kroon; S de Jong; Godefridus J Peters; Frank A E Kruyt
Bortezomib and TRAIL: a perfect match for apoptotic elimination of tumour cells?
Critical reviews in oncology/hematology 2013;85(3):363-72.
2013: Hans M Westgeest; Ronald Hoekstra; Richard J Honeywell; Godefridus J Peters; Nielka P van Erp; Hendrik Verheul
Successful treatment of renal cell carcinoma with sorafenib after effective but hepatotoxic sunitinib exposure.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2013;31(6):e83-6.
2013: Mina Maftouh; Godefridus J Peters; Amir Avan; Elena Galvani; Elisa Giovannetti
Molecular Mechanisms Underlying the Role of MicroRNAs in Resistance to Epidermal Growth Factor Receptor-Targeted Agents and Novel Therapeutic Strategies for Treatment of Non-Small-Cell Lung Cancer.
Critical reviews in oncogenesis 2013;18(4):317-26.
2013: Sanne Martens-de Kemp; Godefridus J Peters; Fiona M J Wijnolts; Boudewijn J M Braakhuis; Arjen Brink; Simone U Dalm; Richard J Honeywell; Ruud H Brakenhoff
DNA-Bound Platinum Is the Major Determinant of Cisplatin Sensitivity in Head and Neck Squamous Carcinoma Cells.
PloS one 2013;8(4):e61555.
2013: Elena Galvani; Elisa Giovannetti; Leticia G Leon; Marco Mor; Roberta Alfieri; Andrea Ardizzoni; Caterina Carmi; Andrea Cavazzoni; Henk Dekker; Pier Giorgio Petronini; Francesca Saccani; Godefridus J Peters
Molecular mechanisms underlying the antitumor activity of 3-aminopropanamide irreversible inhibitors of the epidermal growth factor receptor in non-small cell lung cancer.
Neoplasia (New York, N.Y.) 2013;15(1):61-72.
2013: Sue Ellen Verbrugge; Sonja Zweegman; Marjon Al; Janet L Anderl; Yehuda G Assaraf; Elena T Chan; Jacqueline Cloos; Tanja D de Gruijl; Ben Ac Dijkmans; Christopher J Kirk; Willem F Lems; Denise Niewerth; Godefridus J Peters; George L Scheffer; Rik J Scheper; Michael van der Veer; Johan van Meerloo; Gerrit Jansen
Overcoming bortezomib resistance in human B cells by anti-CD20/rituximab-mediated complement-dependent cytotoxicity and epoxyketone-based irreversible proteasome inhibitors.
Experimental hematology & oncology 2013;2(1):2.
2013: Elisa Giovannetti; Godefridus J Peters
Development of new molecular agents targeting key signalling pathways activated by growth factors in human cancer.
Current pharmaceutical design 2013;19(5):807.
2013: Amir Avan; Adam E Frampton; Nicola Funel; Mina Maftouh; Francesco Nicolini; Serena Pelliccioni; Godefridus J Peters; Karl Quint; Gerrit J Schuurhuis; Elisa Giovannetti
Enhancement of the antiproliferative activity of gemcitabine by modulation of c-Met pathway in pancreatic cancer.
Current pharmaceutical design 2013;19(5):940-50.
2013: Elisa Giovannetti; Richard Honeywell; Mariette Labots; J S W Lind; H Dekker; E Galvani; R Sciarrillo; Egbert F Smit; Hendrik Verheul; Godefridus J Peters
Molecular mechanisms and modulation of key pathways underlying the synergistic interaction of sorafenib with erlotinib in non-small-cell-lung cancer (NSCLC) cells.
Current pharmaceutical design 2013;19(5):927-39.
2013: Elena Galvani; Elisa Giovannetti; Silvia La Monica; Marco Mor; Godefridus J Peters; Pier Giorgio Petronini; Marcello Tiseo; Mara Bonelli; Andrea Cavazzoni; Claudia Fumarola; Maricla Galetti; Roberta Alfieri; Andrea Ardizzoni
Epidermal growth factor receptor tyrosine kinase inhibitors: current status and future perspectives in the development of novel irreversible inhibitors for the treatment of mutant non-small cell lung cancer.
Current pharmaceutical design 2013;19(5):818-32.
2013: Roger M Phillips; Hans R Hendriks; Godefridus J Peters
EO9 (Apaziquone): from the clinic to the laboratory and back again.
British journal of pharmacology 2013;168(1):11-8.
2012: Godefridus J Peters; Irene V Bijnsdorp
TAS-102: more than an antimetabolite.
The lancet oncology 2012;13(12):e518-9.
2012: Godefridus J Peters; Elisa Giovannetti
Highlights from the latest articles in pharmacogenomics of irinotecan/cisplatin toxicity.
Pharmacogenomics 2012;13(13):1445-7.
2012: Marcello Tiseo; Andrew Vincent; Fausto Barbieri; Jacobus A Burgers; Andrea Camerini; Francesco Di Costanzo; Elisa Giovannetti; Godefridus J Peters; Egbert F Smit; Carmelo Tibaldi; Andrea Ardizzoni
Pharmacogenetic study of patients with advanced non-small cell lung cancer (NSCLC) treated with second-line pemetrexed or pemetrexed-carboplatin.
Lung cancer (Amsterdam, Netherlands) 2012;78(1):92-9.
2012: Kaamar Azijli; Steven de Jong; Henk Dekker; Jos Joore; Maikel P Peppelenbosch; Godefridus J Peters; Wim J Quax; Evert van Dijk; Thomas Würdinger; Saravanan Yuvaraj; Frank A E Kruyt
Kinome profiling of non-canonical TRAIL signaling reveals RIP1-Src-STAT3-dependent invasion in resistant non-small cell lung cancer cells.
Journal of cell science 2012;125(Pt 19):4651-61.
2012: Auke D Adema; Richard J Honeywell; Nienke Losekoot; F Myhren; ML Sandvold; Kees Smid; Hendrik Verheul; Godefridus J Peters
Metabolism and accumulation of the lipophilic deoxynucleoside analogs elacytarabine and CP-4126.
Investigational new drugs 2012;30(5):1908-16.
2012: Elena Galvani; Godefridus J Peters; Elisa Giovannetti
EGF receptor-targeted therapy in non-small-cell lung cancer: role of germline polymorphisms in outcome and toxicity.
Future oncology (London, England) 2012;8(8):1015-29.
2012: Amir Avan; Francesco Crea; Romano Danesi; Nicola Funel; Elena Galvani; Richard J Honeywell; Victor E Marquez; Elisa Paolicchi; Godefridus J Peters; Elisa Giovannetti
Molecular mechanisms involved in the synergistic interaction of the EZH2 inhibitor 3-deazaneplanocin A with gemcitabine in pancreatic cancer cells.
Molecular cancer therapeutics 2012;11(8):1735-46.
2012: Elisa Giovannetti; Tommaso De Pas; Francesca Toffalorio; Godefridus J Peters
Pharmacogenetics of conventional chemotherapy in non-small-cell lung cancer: a changing landscape?
Pharmacogenomics 2012;13(9):1073-86.
2012: Franco Muggia; Isabela Diaz; Godefridus J Peters
Nucleoside and nucleobase analogs in cancer treatment: not only sapacitabine, but also gemcitabine.
Expert opinion on investigational drugs 2012;21(4):403-8.
2012: Sue Ellen Verbrugge; Marjon Al; Yehuda G Assaraf; Elena T Chan; Tanja D de Gruijl; Debby den Uyl; Ben A C Dijkmans; Christopher J Kirk; Ruud Oerlemans; Godefridus J Peters; George L Scheffer; Rik J Scheper; Joost van der Heijden; Gerrit Jansen
Inactivating PSMB5 mutations and P-glycoprotein (multidrug resistance-associated protein/ATP-binding cassette B1) mediate resistance to proteasome inhibitors: ex vivo efficacy of (immuno)proteasome inhibitors in mononuclear blood cells from patients with rheumatoid arthritis.
The Journal of pharmacology and experimental therapeutics 2012;341(1):174-82.
2012: Elisa Giovannetti; Giovanni Codacci-Pisanelli; Godefridus J Peters
TFAP2E-DKK4 and chemoresistance in colorectal cancer.
The New England journal of medicine 2012;366(10):966; author reply 966.
2012: Carmelo Tibaldi; Marcello Tiseo; A Ardizzoni; M Bartolotti; F Cappuzzo; A D'Incecco; Elisa Giovannetti; Richard Honeywell; L G Leon; N Loosekoot; Godefridus J Peters
Correlation of cytidine deaminase polymorphisms and activity with clinical outcome in gemcitabine-/platinum-treated advanced non-small-cell lung cancer patients.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2012;23(3):670-7.
2012: Elisa Giovannetti; Romano Danesi; Ayse Erozenci; Jorn Smit; Godefridus J Peters
Molecular mechanisms underlying the role of microRNAs (miRNAs) in anticancer drug resistance and implications for clinical practice.
Critical reviews in oncology/hematology 2012;81(2):103-22.
2012: Elisa Giovannetti; Leticia G Leon; Vittorio Perrone; Luca Pollina; Hiroko Sudo; Arjan van der Velde; Enrico Vasile; Amir Avan; Ugo Boggi; Daniela Campani; Sara Caponi; Nelide De Lio; Alfredo Falcone; Nicola Funel; Valentina Gallá; Godefridus J Peters
High-throughput microRNA (miRNAs) arrays unravel the prognostic role of MiR-211 in pancreatic cancer.
PloS one 2012;7(11):e49145.
2012: Lonneke Timmers; Peter M van de Ven; Christel Clm Boons; Epie Boven; Dirk Mangnus; Godefridus J Peters; Eleonora L Swart; Jacqueline G Hugtenburg
The use of capecitabine in daily practice: a study on adherence and patients' experiences.
Patient preference and adherence 2012;6():741-8.
2012: Lale Erdem; Elisa Giovannetti; Richard Honeywell; Leticia G Leon; Godefridus J Peters
Polymorphisms to predict outcome to the tyrosine kinase inhibitors gefitinib, erlotinib, sorafenib and sunitinib.
Current topics in medicinal chemistry 2012;12(15):1649-59.
2012: Maha Elnaggar; Elisa Giovannetti; Godefridus J Peters
Molecular targets of gemcitabine action: rationale for development of novel drugs and drug combinations.
Current pharmaceutical design 2012;18(19):2811-29.
2011: Jasmina Hodzic; Auke D Adema; Begona Diosdado Calvo; Elisa Giovannetti; Begoňa Diosdado; Godefridus J Peters
Regulation of deoxycytidine kinase expression and sensitivity to gemcitabine by micro-RNA 330 and promoter methylation in cancer cells.
Nucleosides, nucleotides & nucleic acids 2011;30(12):1214-22.
2011: Richard J Honeywell; Elisa Giovannetti; Godefridus J Peters
Determination of the phosphorylated metabolites of gemcitabine and of difluorodeoxyuridine by LCMSMS.
Nucleosides, nucleotides & nucleic acids 2011;30(12):1203-13.
2011: Irene V Bijnsdorp; Godefridus J Peters
Deoxyribose protects against rapamycin-induced cytotoxicity in colorectal cancer cells in vitro.
Nucleosides, nucleotides & nucleic acids 2011;30(12):1197-202.
2011: Godefridus J Peters; Auke D Adema; Irene V Bijnsdorp; ML Sandvold
Lipophilic prodrugs and formulations of conventional (deoxy)nucleoside and fluoropyrimidine analogs in cancer.
Nucleosides, nucleotides & nucleic acids 2011;30(12):1168-80.
2011: Margien L Seinen; Kees Smid; Dirk P van Asseldonk; Adriaan A van Bodegraven; Gerd Bouma; Nanne K H De Boer; Godefridus J Peters
Allopurinol enhances the activity of hypoxanthine-guanine phosphoribosyltransferase in inflammatory bowel disease patients during low-dose thiopurine therapy: preliminary data of an ongoing series.
Nucleosides, nucleotides & nucleic acids 2011;30(12):1085-90.
2011: Tatsuo Hosoya; Kimiyoshi Ichida; Iwao Ohno; Godefridus J Peters
Gout and hyperuricemia in Japan: perspectives for international research on purines and pyrimidines in man.
Nucleosides, nucleotides & nucleic acids 2011;30(12):1001-10.
2011: Elisa Giovannetti; Leticia G Leon; Matteo Lucchesi; Andrea Mambrini; Paola Pacetti; Godefridus J Peters; Michele Reni; Enrico Vasile; Stefano Cereda; Nicola Funel; Michele Ghidini; Maurizio Cantore
Association between DNA-repair polymorphisms and survival in pancreatic cancer patients treated with combination chemotherapy.
Pharmacogenomics 2011;12(12):1641-52.
2011: Famke L Schneiders; H Pieter van den Berg; Godefridus J Peters; Hendrik Verheul; Hans J J van der Vliet
Severe toxicity of capecitabine following uncomplicated treatment with 5-fluorouracil/leucovorin.
Medical oncology (Northwood, London, England) 2011;28(4):1136-9.
2011: Elisa Giovannetti; L G Leon; E Lorenzi; C Alecci; Y G Assaraf; Annarita Destro; F Giancola; L Gianoncelli; M Roncalli; A Santoro; Kees Smid; Paolo Andrea Zucali; Godefridus J Peters
Preclinical emergence of vandetanib as a potent antitumour agent in mesothelioma: molecular mechanisms underlying its synergistic interaction with pemetrexed and carboplatin.
British journal of cancer 2011;105(10):1542-53.
2011: Carlotta Granchi; Mario Lanza; Antonio Lucacchini; Marco Macchia; Adriano Martinelli; Laura Betti; Alessio De Simone; Gino Giannaccini; Elisa Giovannetti; Godefridus J Peters; Sarabindu Roy; Irene Salvetti; Rocco Sciarrillo; Tiziano Tuccinardi; Filippo Minutolo
N-Hydroxyindole-based inhibitors of lactate dehydrogenase against cancer cell proliferation.
European journal of medicinal chemistry 2011;46(11):5398-407.
2011: Elena Galvani; Godefridus J Peters; Elisa Giovannetti
Thymidylate synthase inhibitors for non-small cell lung cancer.
Expert opinion on investigational drugs 2011;20(10):1343-56.
2011: André Bergman; Auke D Adema; Jan Balzarini; Skjalg Bruheim; Iduna Fichtner; Paul Noordhuis; Oystein Fodstad; F Myhren; ML Sandvold; HR Hendriks; Godefridus J Peters
Antiproliferative activity, mechanism of action and oral antitumor activity of CP-4126, a fatty acid derivative of gemcitabine, in in vitro and in vivo tumor models.
Investigational new drugs 2011;29(3):456-66.
2011: Paolo Andrea Zucali; Elisa Giovannetti; Annarita Destro; Manlio Mencoboni; Giovanni Luca Ceresoli; Letizia Gianoncelli; Elena Lorenzi; Fabio De Vincenzo; Matteo Simonelli; Matteo Perrino; Andrea Bruzzone; Erik Thunnissen; Gianni Tunesi; Laura Giordano; Massimo Roncalli; Godefridus J Peters; Armando Santoro
Thymidylate synthase and excision repair cross-complementing group-1 as predictors of responsiveness in mesothelioma patients treated with pemetrexed/carboplatin.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(8):2581-90.
2011: Irene V Bijnsdorp; Reto Schwendener; Herbert Schott; Iduna Fichtner; Kees Smid; Adrie C Laan; Sarah Schott; Nienke Losekoot; Richard J Honeywell; Godefridus J Peters
Cellular pharmacology of multi- and duplex drugs consisting of ethynylcytidine and 5-fluoro-2'-deoxyuridine.
Investigational new drugs 2011;29(2):248-57.
2011: Irene V Bijnsdorp; F Capriotti; Frank A E Kruyt; N Losekoot; Masakazu Fukushima; Arjan W Griffioen; V L Thijssen; Godefridus J Peters
Thymidine phosphorylase in cancer cells stimulates human endothelial cell migration and invasion by the secretion of angiogenic factors.
British journal of cancer 2011;104(7):1185-92.
2011: Carlotta Granchi; Sarabindu Roy; Chiara Giacomelli; Marco Macchia; Tiziano Tuccinardi; Adriano Martinelli; Mario Lanza; Laura Betti; Gino Giannaccini; Antonio Lucacchini; Nicola Funel; Leticia G León; Elisa Giovannetti; Godefridus J Peters; Rahul Palchaudhuri; Emilia C Calvaresi; Paul J Hergenrother; Filippo Minutolo
Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A (LDH-A) as starvation agents against cancer cells.
Journal of medicinal chemistry 2011;54(6):1599-612.
2011: Leticia G León; Elisa Giovannetti; Claudia Alecci; Fiorella Giancola; Niccola Funel; Paolo Zucali; Godefridus J Peters; José M Padrón
Antiproliferative effects of novel aliphatic acetogenin analogs against aggressive solid tumor cell lines.
In vivo (Athens, Greece) 2011;25(2):203-7.
2011: Fleur Broekman; Elisa Giovannetti; Godefridus J Peters
Tyrosine kinase inhibitors: Multi-targeted or single-targeted?
World journal of clinical oncology 2011;2(2):80-93.
2011: Clara Lemos; Elisa Giovannetti; Paolo A Zucali; Yehuda G Assaraf; George L Scheffer; Tahar van der Straaten; Armida D'Incecco; Alfredo Falcone; Henk-Jan Guchelaar; Romano Danesi; Armando Santoro; Giuseppe Giaccone; Carmelo Tibaldi; Godefridus J Peters
Impact of ABCG2 polymorphisms on the clinical outcome and toxicity of gefitinib in non-small-cell lung cancer patients.
Pharmacogenomics 2011;12(2):159-70.
2011: Carmelo Tibaldi; Elisa Giovannetti; Enrico Vasile; Laura Boldrini; Marielle I Gallegos-Ruiz; Ilaria Bernardini; Roberto Incensati; Romano Danesi; Federico Cappuzzo; Godefridus J Peters; Gabriella Fontanini
Inherited germline T790M mutation and somatic epidermal growth factor receptor mutations in non-small cell lung cancer patients.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2011;6(2):395-6.
2011: Irene V Bijnsdorp; Elisa Giovannetti; Godefridus J Peters
Analysis of drug interactions.
Methods in molecular biology (Clifton, N.J.) 2011;731():421-34.
2011: Elisa Giovannetti; Lale Erdem; Efnan Olcay; Leticia G Leon; Godefridus J Peters
Influence of polymorphisms on EGFR targeted therapy in non-small-cell lung cancer.
Frontiers in bioscience : a journal and virtual library 2011;16():116-30.
2010: Irene V Bijnsdorp; K Azijli; Erwin E W Jansen; Mirjam M C Wamelink; Cornelis Jakobs; Eduard A Struys; Masakazu Fukushima; Frank A E Kruyt; Godefridus J Peters
Accumulation of thymidine-derived sugars in thymidine phosphorylase overexpressing cells.
Biochemical pharmacology 2010;80(6):786-92.
2010: Jennifer Sigmond; André Bergman; Leticia G Leon; Willem J P Loves; Eveline K Hoebe; Godefridus J Peters
Staurosporine increases toxicity of gemcitabine in non-small cell lung cancer cells: role of protein kinase C, deoxycytidine kinase and ribonucleotide reductase.
Anti-cancer drugs 2010;21(6):591-9.
2010: Irene V Bijnsdorp; K Vrijland; L Vroling; Masakazu Fukushima; Godefridus J Peters
Increased migration by stimulation of thymidine phosphorylase in endothelial cells of different origin.
Nucleosides, nucleotides & nucleic acids 2010;29(4-6):482-7.
2010: Elisa Giovannetti; L G Leon; S Bertini; M Macchia; F Minutolo; N Funel; C Alecci; F Giancola; Romano Danesi; Godefridus J Peters
Study of apoptosis induction and deoxycytidine kinase/cytidine deaminase modulation in the synergistic interaction of a novel ceramide analog and gemcitabine in pancreatic cancer cells.
Nucleosides, nucleotides & nucleic acids 2010;29(4-6):419-26.
2010: Godefridus J Peters; J Hodzic; B Ortega; Elisa Giovannetti; Auke D Adema; Richard Broekhuizen; G J L Kaspers; Isabelle Hubeek
Methylation specific PCR to characterize methylation of the promoter of deoxycytidine kinase.
Nucleosides, nucleotides & nucleic acids 2010;29(4-6):408-13.
2010: Auke D Adema; N Losekoot; Kees Smid; Ietje Kathmann; F Myhren; ML Sandvold; Godefridus J Peters
Induction of resistance to the lipophilic cytarabine prodrug elacytarabine (CP-4055) in CEM leukemic cells.
Nucleosides, nucleotides & nucleic acids 2010;29(4-6):394-9.
2010: D P van Asseldonk; Nanne K H De Boer; Kees Smid; Chris J J Mulder; Ad van Bodegraven; Godefridus J Peters
Limited intra-individual variability in hypoxanthine-Guanine phosphoribosyl transferase, thiopurine S-methyl transferase, and xanthine oxidase activity in inflammatory bowel disease patients during 6-thioguanine therapy.
Nucleosides, nucleotides & nucleic acids 2010;29(4-6):284-90.
2010: Staffan Eriksson; Godefridus J Peters
Purine and pyrimidine metabolism in the fist decade of the 21st century--highlights and perspectives.
Nucleosides, nucleotides & nucleic acids 2010;29(4-6):i-xi.
2010: Elisa Giovannetti; Nicola Funel; Godefridus J Peters; Marco Del Chiaro; Leyla A Erozenci; Enrico Vasile; Leticia G Leon; Luca Pollina; Annemieke Groen; Alfredo Falcone; Romano Danesi; Daniela Campani; Hendrik Verheul; Ugo Boggi
MicroRNA-21 in pancreatic cancer: correlation with clinical outcome and pharmacologic aspects underlying its role in the modulation of gemcitabine activity.
Cancer research 2010;70(11):4528-38.
2010: Joline S W Lind; Anne-Marie C Dingemans; Harry J M Groen; Frederik B Thunnissen; Otto Bekers; Daniëlle A M Heideman; Richard J Honeywell; Elisa Giovannetti; Godefridus J Peters; Pieter E Postmus; Robert Jan van Suylen; Egbert F Smit
A multicenter phase II study of erlotinib and sorafenib in chemotherapy-naive patients with advanced non-small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(11):3078-87.
2010: Irene V Bijnsdorp; Godefridus J Peters; Olaf H Temmink; Masakazu Fukushima; Frank A E Kruyt
Differential activation of cell death and autophagy results in an increased cytotoxic potential for trifluorothymidine compared to 5-fluorouracil in colon cancer cells.
International journal of cancer. Journal international du cancer 2010;126(10):2457-68.
2010: Elisa Giovannetti; Carmelo Tibaldi; Alfredo Falcone; Romano Danesi; Godefridus J Peters
Impact of cytidine deaminase polymorphisms on toxicity after gemcitabine: the question is still ongoing.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010;28(14):e221-2; author reply e223-5.
2010: Olaf H Temmink; Irene V Bijnsdorp; Henk-Jan Prins; Nienke Losekoot; Auke D Adema; Kees Smid; Richard J Honeywell; Bauke Ylstra; Paul P Eijk; Masakazu Fukushima; Godefridus J Peters
Trifluorothymidine resistance is associated with decreased thymidine kinase and equilibrative nucleoside transporter expression or increased secretory phospholipase A2.
Molecular cancer therapeutics 2010;9(4):1047-57.
2010: Elisa Giovannetti; Paolo A Zucali; Godefridus J Peters; Filippo Cortesi; Armida D'Incecco; Egbert F Smit; Alfredo Falcone; Jacobus A Burgers; Armando Santoro; Romano Danesi; Giuseppe Giaccone; Carmelo Tibaldi
Association of polymorphisms in AKT1 and EGFR with clinical outcome and toxicity in non-small cell lung cancer patients treated with gefitinib.
Molecular cancer therapeutics 2010;9(3):581-93.
2010: Irene V Bijnsdorp; Frank A E Kruyt; Masakazu Fukushima; Kees Smid; Shanti Gokoel; Godefridus J Peters
Molecular mechanism underlying the synergistic interaction between trifluorothymidine and the epidermal growth factor receptor inhibitor erlotinib in human colorectal cancer cell lines.
Cancer science 2010;101(2):440-7.
2010: Jin-Hyeok Hwang; Johannes Voortman; Elisa Giovannetti; Seth M Steinberg; Leticia G Leon; Yong-Tae Kim; Niccola Funel; Joo Kyung Park; Min A Kim; Gyeong Hoon Kang; Sun-Whe Kim; Marco Del Chiaro; Godefridus J Peters; Giuseppe Giaccone
Identification of microRNA-21 as a biomarker for chemoresistance and clinical outcome following adjuvant therapy in resectable pancreatic cancer.
PloS one 2010;5(5):e10630.
2010: Auke D Adema; Adrie C Laan; F Myhren; Iduna Fichtner; Hendrik Verheul; ML Sandvold; Godefridus J Peters
Cell cycle effects of fatty acid derivatives of cytarabine, CP-4055, and of gemcitabine, CP-4126, as basis for the interaction with oxaliplatin and docetaxel.
International journal of oncology 2010;36(1):285-94.
2010: Elisa Giovannetti; Richard Honeywell; Axel R Hanauske; Christina Tekle; Bart Kuenen; Jennifer Sigmond; Giuseppe Giaccone; Godefridus J Peters
Pharmacological aspects of the enzastaurin-pemetrexed combination in non-small cell lung cancer (NSCLC).
Current drug targets 2010;11(1):12-28.
2009: Dirk P Van Asseldonk; Nanne K H De Boer; Godefridus J Peters; Agnes I Veldkamp; Chris J Mulder; Ad van Bodegraven
On therapeutic drug monitoring of thiopurines in inflammatory bowel disease; pharmacology, pharmacogenomics, drug intolerance and clinical relevance.
Current drug metabolism 2009;10(9):981-97.
2009: Yergeri C Mayur; Godefridus J Peters; Clara Lemos; Ietje Kathmann; Velivela V S Rajendra Prasad
Synthesis of 2-fluoro N(10)-substituted acridones and their cytotoxicity studies in sensitive and resistant cancer cell lines and their DNA intercalation studies.
Archiv der Pharmazie 2009;342(11):640-50.
2009: J M van Riel; Godefridus J Peters; L H Mammatas; R J Honeywell; Adrie C Laan; R Ruyter; F G van den Berg; Giuseppe Giaccone; Cees J van Groeningen
A phase I and pharmacokinetic study of gemcitabine given by 24-h hepatic arterial infusion.
European journal of cancer (Oxford, England : 1990) 2009;45(14):2519-27.
2009: Robert Mauritz; Elisa Giovannetti; Ines J Beumer; Kees Smid; Cees J van Groeningen; HERBERT PINEDO; Godefridus J Peters
Polymorphisms in the enhancer region of the thymidylate synthase gene are associated with thymidylate synthase levels in normal tissues but not in malignant tissues of patients with colorectal cancer.
Clinical colorectal cancer 2009;8(3):146-54.
2009: Francesco Crea; Elisa Giovannetti; Filippo Cortesi; Valentina Mey; Sara Nannizzi; Marielle I Gallegos Ruiz; Simona Ricciardi; Mario Del Tacca; Godefridus J Peters; Romano Danesi
Epigenetic mechanisms of irinotecan sensitivity in colorectal cancer cell lines.
Molecular cancer therapeutics 2009;8(7):1964-73.
2009: Auke D Adema; Kasper van der Born; R J Honeywell; Godefridus J Peters
Cell cycle effects and increased adduct formation by temozolomide enhance the effect of cytotoxic and targeted agents in lung cancer cell lines.
Journal of chemotherapy (Florence, Italy) 2009;21(3):338-46.
2009: Franco M Muggia; Godefridus J Peters; Joseph R Landolph
XIII International Charles Heidelberger Symposium and 50 Years of Fluoropyrimidines in Cancer Therapy Held on september 6 to 8, 2007 at New York University Cancer Institute, Smilow Conference Center.
Molecular cancer therapeutics 2009;8(5):992-9.
2009: Cecilia Ceresa; Elisa Giovannetti; Johannes Voortman; Adrie C Laan; Richard Honeywell; Giuseppe Giaccone; Godefridus J Peters
Bortezomib induces schedule-dependent modulation of gemcitabine pharmacokinetics and pharmacodynamics in non-small cell lung cancer and blood mononuclear cells.
Molecular cancer therapeutics 2009;8(5):1026-36.
2009: Alan Kambiz Fotoohi; Yehuda G Assaraf; Ali Moshfegh; Jamileh Hashemi; Gerrit Jansen; Godefridus J Peters; Catharina Larsson; Freidoun Albertioni
Gene expression profiling of leukemia T-cells resistant to methotrexate and 7-hydroxymethotrexate reveals alterations that preserve intracellular levels of folate and nucleotide biosynthesis.
Biochemical pharmacology 2009;77(8):1410-7.
2009: Clara Lemos; Ietje Kathmann; Elisa Giovannetti; Conceição Calhau; G Jansen; Godefridus J Peters
Impact of cellular folate status and epidermal growth factor receptor expression on BCRP/ABCG2-mediated resistance to gefitinib and erlotinib.
British journal of cancer 2009;100(7):1120-7.
2009: Robert de Jonge; Wim J E Tissing; Jan Hendrik Hooijberg; Gerrit Jansen; G J L Kaspers; Jan Lindemans; Godefridus J Peters; Rob Pieters
Polymorphisms in folate-related genes and risk of pediatric acute lymphoblastic leukemia.
Blood 2009;113(10):2284-9.
2009: Clara Lemos; Ietje Kathmann; Elisa Giovannetti; Jeroen A M Beliën; George L Scheffer; Conceição Calhau; Gerrit Jansen; Godefridus J Peters
Cellular folate status modulates the expression of BCRP and MRP multidrug transporters in cancer cell lines from different origins.
Molecular cancer therapeutics 2009;8(3):655-64.
2009: M I Galleges Ruiz; Karijn Floor; S M Steinberg; Katrien Grunberg; F B J M Thunnissen; J A M Belien; Gerrit A Meijer; Godefridus J Peters; Egbert F Smit; Jose A Rodriguez; Giuseppe Giaccone
Combined assessment of EGFR pathway-related molecular markers and prognosis of NSCLC patients.
British journal of cancer 2009;100(1):145-52.
2009: Auke D Adema; Irene V Bijnsdorp; ML Sandvold; Hendrik Verheul; Godefridus J Peters
Innovations and opportunities to improve conventional (deoxy)nucleoside and fluoropyrimidine analogs in cancer.
Current medicinal chemistry 2009;16(35):4632-43.
2009: Roland Andersson; Ursula Aho; Bo I Nilsson; Godefridus J Peters; Marçal Pastor-Anglada; Wenche Rasch; Marit L Sandvold
Gemcitabine chemoresistance in pancreatic cancer: molecular mechanisms and potential solutions.
Scandinavian journal of gastroenterology 2009;44(7):782-6.
2009: Letizia Porcelli; Clara Lemos; Godefridus J Peters; angelo paradiso; Amalia Azzariti
Intracellular trafficking of MDR transporters and relevance of SNPs.
Current topics in medicinal chemistry 2009;9(2):197-208.
2008: Irene V Bijnsdorp; Frank A E Kruyt; S Gokoel; Masakazu Fukushima; Godefridus J Peters
Synergistic interaction between trifluorothymidine and docetaxel is sequence dependent.
Cancer science 2008;99(11):2302-8.
2008: Robert Mauritz; Godefridus J Peters; Ietje Kathmann; Habte Teshale; Paul Noordhuis; Elizabeth M Comijn; HERBERT PINEDO; Gerrit Jansen
Dynamics of antifolate transport via the reduced folate carrier and the membrane folate receptor in murine leukaemia cells in vitro and in vivo.
Cancer chemotherapy and pharmacology 2008;62(6):937-48.
2008: Clara Lemos; Ietje Kathmann; Elisa Giovannetti; Henk Dekker; George L Scheffer; Conceição Calhau; Gerrit Jansen; Godefridus J Peters
Folate deprivation induces BCRP (ABCG2) expression and mitoxantrone resistance in Caco-2 cells.
International journal of cancer. Journal international du cancer 2008;123(7):1712-20.
2008: Ruud Oerlemans; Niels E Franke; Yehuda G Assaraf; Jacqueline Cloos; Ina van Zantwijk; Celia R Berkers; George L Scheffer; Kabir Debipersad; Katharina Vojtekova; Clara Lemos; Joost W van der Heijden; Bauke Ylstra; Godefridus J Peters; Gertjan L Kaspers; Ben A C Dijkmans; Rik J Scheper; Gerrit Jansen
Molecular basis of bortezomib resistance: proteasome subunit beta5 (PSMB5) gene mutation and overexpression of PSMB5 protein.
Blood 2008;112(6):2489-99.
2008: C Tekle; Elisa Giovannetti; Jennifer Sigmond; J R Graff; Kees Smid; Godefridus J Peters
Molecular pathways involved in the synergistic interaction of the PKC beta inhibitor enzastaurin with the antifolate pemetrexed in non-small cell lung cancer cells.
British journal of cancer 2008;99(5):750-9.
2008: W G E Direcks; S C Berndsen; N Proost; Godefridus J Peters; J Balzarini; Marieke D Spreeuwenberg; A A Lammertsma; Carla F M Molthoff
[18F]FDG and [18F]FLT uptake in human breast cancer cells in relation to the effects of chemotherapy: an in vitro study.
British journal of cancer 2008;99(3):481-7.
2008: Rutger W H M Staffhorst; Kasper van der Born; Caroline A M Erkelens; Irene H L Hamelers; Godefridus J Peters; Epie Boven; Anton I P M de Kroon
Antitumor activity and biodistribution of cisplatin nanocapsules in nude mice bearing human ovarian carcinoma xenografts.
Anti-cancer drugs 2008;19(7):721-7.
2008: Paul Noordhuis; Adrie C Laan; Kasper van de Born; Nienke Losekoot; Ietje Kathmann; Godefridus J Peters
Oxaliplatin activity in selected and unselected human ovarian and colorectal cancer cell lines.
Biochemical pharmacology 2008;76(1):53-61.
2008: Isabelle Hubeek; Elisa Giovannetti; A J F Broekhuizen; M Pastor-Anglada; G J L Kaspers; Godefridus J Peters
Immunocytochemical detection of hENT1 and hCNT1 in normal tissues, lung cancer cell lines, and NSCLC patient samples.
Nucleosides, nucleotides & nucleic acids 2008;27(6):787-93.
2008: Elisa Giovannetti; Harold H J Backus; Dorine Wouters; Godefridus J Peters
Functional inactivity and mutations of p53 differentially affect sensitivity to 5-fluorouracil and antifolate inhibitors of thymidylate synthase (TS) by altering TS levels in colorectal cancer cells.
Nucleosides, nucleotides & nucleic acids 2008;27(6):740-5.
2008: Giovanni Codacci-Pisanelli; Paul Noordhuis; Clasina L Van der Wilt; Godefridus J Peters
Selective protection by uridine of growth inhibition by 5-fluorouracil (5FU) mediated by 5FU incorporation into RNA, but not the thymidylate synthase mediated growth inhibition by 5FU-leucovorin.
Nucleosides, nucleotides & nucleic acids 2008;27(6):733-9.
2008: Elisa Giovannetti; Adrie C Laan; E Vasile; C Tibaldi; S Nannizzi; S Ricciardi; Alfredo Falcone; Romano Danesi; Godefridus J Peters
Correlation between cytidine deaminase genotype and gemcitabine deamination in blood samples.
Nucleosides, nucleotides & nucleic acids 2008;27(6):720-5.
2008: Irene V Bijnsdorp; Frank A E Kruyt; Masakazu Fukushima; Godefridus J Peters
Trifluorothymidine induces cell death independently of p53.
Nucleosides, nucleotides & nucleic acids 2008;27(6):699-703.
2008: Irene V Bijnsdorp; Michiel de Bruin; Adrie C Laan; Masakazu Fukushima; Godefridus J Peters
The role of platelet-derived endothelial cell growth factor/thymidine phosphorylase in tumor behavior.
Nucleosides, nucleotides & nucleic acids 2008;27(6):681-91.
2008: Isabelle Hubeek; Elizabeth M Comijn; Clasina L Van der Wilt; Ronald L Merriman; Jose Padron; G J L Kaspers; Godefridus J Peters
CI-994 (N-acetyl-dinaline) in combination with conventional anti-cancer agents is effective against acute myeloid leukemia in vitro and in vivo.
Oncology reports 2008;19(6):1517-23.
2008: Elisa Giovannetti; Clara Lemos; Christina Tekle; Kees Smid; Sara Nannizzi; José A Rodriguez; Simona Ricciardi; Romano Danesi; Giuseppe Giaccone; Godefridus J Peters
Molecular mechanisms underlying the synergistic interaction of erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor, with the multitargeted antifolate pemetrexed in non-small-cell lung cancer cells.
Molecular pharmacology 2008;73(4):1290-300.
2008: Carmelo Tibaldi; Elisa Giovannetti; Enrico Vasile; Valentina Mey; Adrie C Laan; Sara Nannizzi; Roberta Di Marsico; Andrea Antonuzzo; Cinzia Orlandini; Simona Ricciardi; Mario Del Tacca; Godefridus J Peters; Alfredo Falcone; Romano Danesi
Correlation of CDA, ERCC1, and XPD polymorphisms with response and survival in gemcitabine/cisplatin-treated advanced non-small cell lung cancer patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(6):1797-803.
2008: C Lemos; G Jansen; Godefridus J Peters
Drug transporters: recent advances concerning BCRP and tyrosine kinase inhibitors.
British journal of cancer 2008;98(5):857-62.
2008: Marcel N A Bijman; Cristian A Hermelink; Maria P A van Berkel; Adrie C Laan; Maarten L Janmaat; Godefridus J Peters; Epie Boven
Interaction between celecoxib and docetaxel or cisplatin in human cell lines of ovarian cancer and colon cancer is independent of COX-2 expression levels.
Biochemical pharmacology 2008;75(2):427-37.
2008: Irene V Bijnsdorp; Reto Schwendener; H Schott; S Schott; Iduna Fichtner; R J Honeywell; N Losekoot; Adrie C Laan; Godefridus J Peters
In vitro activity and mechanism of action of a duplex and multidrug of ethynylcytidine and 5-fluorodeoxyuridine.
Nucleic acids symposium series (2004) 2008;(52):651.
2008: Elisa Giovannetti; Dewa G Ugrasena; Eddy Supriyadi; Laura Vroling; Antonino Azzarello; Desiree de Lange; Godefridus J Peters; Anjo J P Veerman; Jacqueline Cloos
Methylenetetrahydrofolate reductase (MTHFR) C677T and thymidylate synthase promoter (TSER) polymorphisms in Indonesian children with and without leukemia.
Leukemia research 2008;32(1):19-24.
2007: Dennis Fontijn; Auke D Adema; Kishor K Bhakat; HERBERT PINEDO; Godefridus J Peters; Epie Boven
O6-methylguanine-DNA-methyltransferase promoter demethylation is involved in basic fibroblast growth factor induced resistance against temozolomide in human melanoma cells.
Molecular cancer therapeutics 2007;6(10):2807-15.
2007: Clara Lemos; Godefridus J Peters; Gerrit Jansen; Fátima Martel; Conceição Calhau
Modulation of folate uptake in cultured human colon adenocarcinoma Caco-2 cells by dietary compounds.
European journal of nutrition 2007;46(6):329-36.
2007: Weidong Wu; Jennifer Sigmond; Godefridus J Peters; Richard F Borch
Synthesis and biological activity of a gemcitabine phosphoramidate prodrug.
Journal of medicinal chemistry 2007;50(15):3743-6.
2007: Irene V Bijnsdorp; Elizabeth M Comijn; Jose Padron; W H Gmeiner; Godefridus J Peters
Mechanisms of action of FdUMP[10]: metabolite activation and thymidylate synthase inhibition.
Oncology reports 2007;18(1):287-91.
2007: Johannes Voortman; Egbert F Smit; Richard Honeywell; Bart C Kuenen; Godefridus J Peters; Helgi van de Velde; Giuseppe Giaccone
A parallel dose-escalation study of weekly and twice-weekly bortezomib in combination with gemcitabine and cisplatin in the first-line treatment of patients with advanced solid tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(12):3642-51.
2007: Robert Mauritz; Cees J van Groeningen; Kees Smid; Gerrit Jansen; HERBERT PINEDO; Godefridus J Peters
Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expression after administration of 5-fluorouracil to patients with colorectal cancer.
International journal of cancer. Journal international du cancer 2007;120(12):2609-12.
2007: Olaf H Temmink; Tomohiro Emura; Michiel de Bruin; Masakazu Fukushima; Godefridus J Peters
Therapeutic potential of the dual-targeted TAS-102 formulation in the treatment of gastrointestinal malignancies.
Cancer science 2007;98(6):779-89.
2007: Jennifer Sigmond; J A E Kamphuis; Adrie C Laan; Eveline K Hoebe; André Bergman; Godefridus J Peters
The synergistic interaction of gemcitabine and cytosine arabinoside with the ribonucleotide reductase inhibitor triapine is schedule dependent.
Biochemical pharmacology 2007;73(10):1548-57.
2007: Marco Radi; Auke D Adema; Jonathan R Daft; Jong H Cho; Eveline K Hoebe; Lou-Ella M M Alexander; Godefridus J Peters; Chung (David) K. Chu
In vitro optimization of non-small cell lung cancer activity with troxacitabine, L-1,3-dioxolane-cytidine, prodrugs.
Journal of medicinal chemistry 2007;50(9):2249-53.
2007: Bart P H Wittgen; Peter W A Kunst; Kasper van der Born; Atie W van Wijk; Walter Perkins; Frank G Pilkiewicz; Roman Perez-Soler; Susan Nicholson; Godefridus J Peters; Pieter E Postmus
Phase I study of aerosolized SLIT cisplatin in the treatment of patients with carcinoma of the lung.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(8):2414-21.
2007: Godefridus J Peters; MD Clavel; Paul Noordhuis; G J Geyssen; Adrie C Laan; Jean-Paul Guastalla; H T Edzes; Jan B Vermorken
Clinical phase I and pharmacology study of gemcitabine (2', 2'-difluorodeoxycytidine) administered in a two-weekly schedule.
Journal of chemotherapy (Florence, Italy) 2007;19(2):212-21.
2007: Elisa Giovannetti; Harold H J Backus; Dorine Wouters; Carlos G Ferreira; Viola M M van Houten; Ruud H Brakenhoff; M-F Poupon; A Azzarello; HERBERT PINEDO; Godefridus J Peters
Changes in the status of p53 affect drug sensitivity to thymidylate synthase (TS) inhibitors by altering TS levels.
British journal of cancer 2007;96(5):769-75.
2007: Richard Honeywell; Adrie C Laan; Cees J van Groeningen; E Strocchi; R Ruiter; Giuseppe Giaccone; Godefridus J Peters
The determination of gemcitabine and 2'-deoxycytidine in human plasma and tissue by APCI tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;847(2):142-52.
2007: Olaf H Temmink; Eveline K Hoebe; Kasper van der Born; SP Ackland; Masakazu Fukushima; Godefridus J Peters
Mechanism of trifluorothymidine potentiation of oxaliplatin-induced cytotoxicity to colorectal cancer cells.
British journal of cancer 2007;96(2):231-40.
2007: Olaf H Temmink; H-J Prins; Edwin van Gelderop; Godefridus J Peters
The Hollow Fibre Assay as a model for in vivo pharmacodynamics of fluoropyrimidines in colon cancer cells.
British journal of cancer 2007;96(1):61-6.
2007: Irene V Bijnsdorp; Reto Schwendener; Herbert Schott; Iduna Fichtner; Kees Smid; Sarah Schott; Adrie C Laan; Godefridus J Peters
In vivo and in vitro activity and mechanism of action of the multidrug cytarabine-L-glycerylyl-fluorodeoxyuridine.
Nucleosides, nucleotides & nucleic acids 2007;26(10-12):1619-24.
2007: Auke D Adema; M Radi; J Daft; J Narayanasamy; Eveline K Hoebe; L E Alexander; Chung (David) K. Chu; Godefridus J Peters
Troxacitabine prodrugs for pancreatic cancer.
Nucleosides, nucleotides & nucleic acids 2007;26(8-9):1073-7.
2007: Olaf H Temmink; Michiel de Bruin; Annelies W Turksma; Silvia Cricca; Adrie C Laan; Godefridus J Peters
Activity and substrate specificity of pyrimidine phosphorylases and their role in fluoropyrimidine sensitivity in colon cancer cell lines.
The international journal of biochemistry & cell biology 2007;39(3):565-75.
2007: Olaf H Temmink; Eveline K Hoebe; Masakazu Fukushima; Godefridus J Peters
Irinotecan-induced cytotoxicity to colon cancer cells in vitro is stimulated by pre-incubation with trifluorothymidine.
European journal of cancer (Oxford, England : 1990) 2007;43(1):175-83.
2006: Jaap Haveman; Jennifer Sigmond; Chris van Bree; N A P Franken; C Koedooder; Godefridus J Peters
Time course of enhanced activity of deoxycytidine kinase and thymidine kinase 1 and 2 in cultured human squamous lung carcinoma cells, SW-1573, induced by gamma-irradiation.
Oncology reports 2006;16(4):901-5.
2006: Judith R Kroep; Egbert F Smit; Giuseppe Giaccone; Kasper van der Born; Jos H Beijnen; Cees J van Groeningen; Wim J F van der Vijgh; Pieter E Postmus; HERBERT PINEDO; Godefridus J Peters
Pharmacology of the paclitaxel-cisplatin, gemcitabine-cisplatin, and paclitaxel-gemcitabine combinations in patients with advanced non-small cell lung cancer.
Cancer chemotherapy and pharmacology 2006;58(4):509-16.
2006: Jan Hendrik Hooijberg; N A de Vries; G J L Kaspers; Rob Pieters; Gerrit Jansen; Godefridus J Peters
Multidrug resistance proteins and folate supplementation: therapeutic implications for antifolates and other classes of drugs in cancer treatment.
Cancer chemotherapy and pharmacology 2006;58(1):1-12.
2006: Jose Padron; Godefridus J Peters
Cytotoxicity of sphingoid marine compound analogs in mono- and multilayered solid tumor cell cultures.
Investigational new drugs 2006;24(3):195-202.
2006: Richard Honeywell; Cees J van Groeningen; Adrie C Laan; E Strocchi; R Ruiter; Giuseppe Giaccone; Godefridus J Peters
Analysis of deoxycytidine accumulation in gemcitabine treated patients.
Nucleosides, nucleotides & nucleic acids 2006;25(9-11):1225-32.
2006: Jennifer Sigmond; Jaap Haveman; N Castro Kreder; Willem J P Loves; Chris van Bree; N A P Franken; Godefridus J Peters
Enhanced activity of deoxycytidine kinase after pulsed low dose rate and single dose gamma irradiation.
Nucleosides, nucleotides & nucleic acids 2006;25(9-11):1177-80.
2006: Kees Smid; André Bergman; Paul P Eijk; Gijsbert Veerman; V W T Ruiz van Haperen; Paul van den IJssel; Bauke Ylstra; Godefridus J Peters
Micro-array analysis of resistance for gemcitabine results in increased expression of ribonucleotide reductase subunits.
Nucleosides, nucleotides & nucleic acids 2006;25(9-11):1001-7.
2006: Auke D Adema; L Zuurbier; Karijn Floor; Isabelle Hubeek; G J L Kaspers; F Albertoni; Godefridus J Peters
Cellular resistance against troxacitabine in human cell lines and pediatric patient acute myeloid leukemia blast cells.
Nucleosides, nucleotides & nucleic acids 2006;25(9-11):981-6.
2006: Godefridus J Peters; E A Carrey; I Sebesta
Purine and pyrimidine metabolism: a firm basis for a transformed society.
Nucleosides, nucleotides & nucleic acids 2006;25(9-11):971-4.
2006: Olaf H Temmink; Michiel de Bruin; Adrie C Laan; A W Turksma; S Cricca; Allan J Masterson; Paul Noordhuis; Godefridus J Peters
The role of thymidine phosphorylase and uridine phosphorylase in (fluoro)pyrimidine metabolism in peripheral blood mononuclear cells.
The international journal of biochemistry & cell biology 2006;38(10):1759-65.
2006: Bea Pauwels; Annelies E C Korst; Greet G O Pattyn; Hilde A J Lambrechts; Juliette A E Kamphuis; Christel M J de Pooter; Godefridus J Peters; Filip Lardon; Jan B Vermorken
The relation between deoxycytidine kinase activity and the radiosensitising effect of gemcitabine in eight different human tumour cell lines.
BMC cancer 2006;6():142.
2006: Isabelle Hubeek; Godefridus J Peters; Richard Broekhuizen; Christian M Zwaan; Patricia Kaaijk; Elisabeth S van Wering; Brenda E S Gibson; Ursula Creutzig; Gritta E Janka-Schaub; Monique L den Boer; Rob Pieters; G J L Kaspers
In vitro sensitivity and cross-resistance to deoxynucleoside analogs in childhood acute leukemia.
Haematologica 2006;91(1):17-23.
2006: Godefridus J Peters; Catharina J A Van Moorsel; Bianca Lakerveld; Kees Smid; Paul Noordhuis; Elizabeth C Comijn; Dennis Weaver; James Willey; Daphne Voorn; Wim J F van der Vijgh; HERBERT PINEDO
Effects of gemcitabine on cis-platinum-DNA adduct formation and repair in a panel of gemcitabine and cisplatin-sensitive or -resistant human ovarian cancer cell lines.
International journal of oncology 2006;28(1):237-44.
2006: Carolien H Smorenburg; Godefridus J Peters; Cees J van Groeningen; Paul Noordhuis; Kees Smid; A M G H van Riel; W Dercksen; HERBERT PINEDO; Giuseppe Giaccone
Phase II study of tailored chemotherapy for advanced colorectal cancer with either 5-fluouracil and leucovorin or oxaliplatin and irinotecan based on the expression of thymidylate synthase and dihydropyrimidine dehydrogenase.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2006;17(1):35-42.
2006: Olaf H Temmink; Marco F M Hoogeland; Masakazu Fukushima; Godefridus J Peters
Low folate conditions may enhance the interaction of trifluorothymidine with antifolates in colon cancer cells.
Cancer chemotherapy and pharmacology 2006;57(2):171-9.
2005: Isabelle Hubeek; Ronald W Stam; Godefridus J Peters; Richard Broekhuizen; Jules P P Meijerink; Elisabeth R van Wering; Brenda E S Gibson; Ursula Creutzig; Christian M Zwaan; Jacqueline Cloos; Dirk J Kuik; Rob Pieters; G J L Kaspers
The human equilibrative nucleoside transporter 1 mediates in vitro cytarabine sensitivity in childhood acute myeloid leukaemia.
British journal of cancer 2005;93(12):1388-94.
2005: SM de Lange; Kasper van der Born; Judith R Kroep; Helle Anita Jensen; P Pfeiffer; A Cleverly; Cees J van Groeningen; Godefridus J Peters
No evidence of gemcitabine accumulation during weekly administration.
European journal of clinical pharmacology 2005;61(11):843-9.
2005: Mark A van de Wiel; Jose L Costa; Kees Smid; Cees B M Oudejans; André Bergman; Gerrit A Meijer; Godefridus J Peters; Bauke Ylstra
Expression microarray analysis and oligo array comparative genomic hybridization of acquired gemcitabine resistance in mouse colon reveals selection for chromosomal aberrations.
Cancer research 2005;65(22):10208-13.
2005: André Bergman; Paul P Eijk; Veronique Ruiz van Haperen; Kees Smid; Gijsbert Veerman; Isabelle Hubeek; Paul van den IJssel; Bauke Ylstra; Godefridus J Peters
In vivo induction of resistance to gemcitabine results in increased expression of ribonucleotide reductase subunit M1 as the major determinant.
Cancer research 2005;65(20):9510-6.
2005: Isabelle Hubeek; Godefridus J Peters; A J F Broekhuizen; J Sargent; Brenda E S Gibson; Ursula Creutzig; G J L Kaspers
Potentiation of in vitro ara-C cytotoxicity by ribonucleotide reductase inhibitors, cyclin-dependent kinase modulators and the DNA repair inhibitor aphidicolin in paediatric acute myeloid leukaemia.
British journal of haematology 2005;131(2):219-22.
2005: Assaf Shafran; Ilan Ifergan; Eran Bram; Gerrit Jansen; Ietje Kathmann; Godefridus J Peters; Robert W Robey; Susan E Bates; Yehuda G Assaraf
ABCG2 harboring the Gly482 mutation confers high-level resistance to various hydrophilic antifolates.
Cancer research 2005;65(18):8414-22.
2005: Robert de Jonge; Jan Hendrik Hooijberg; Bertrand D van Zelst; Gerrit Jansen; Gerritz Jansen; Christina H van Zantwijk; Christine H van Zantwijk; G J L Kaspers; Gert Jan L Kaspers; Godefridus J Peters; Frits G J Peters; Yaddanapudi Ravindranath; Rob Pieters; Jan Lindemans
Effect of polymorphisms in folate-related genes on in vitro methotrexate sensitivity in pediatric acute lymphoblastic leukemia.
Blood 2005;106(2):717-20.
2005: Isabelle Hubeek; Godefridus J Peters; A J F Broekhuizen; Iannis Talianidis; Jennifer Sigmond; Brenda E S Gibson; Ursula Creutzig; G Giaccone; G J L Kaspers
Immunocytochemical detection of deoxycytidine kinase in haematological malignancies and solid tumours.
Journal of clinical pathology 2005;58(7):695-9.
2005: Giovanni Codacci-Pisanelli; HERBERT PINEDO; Jan Lankelma; Cees J van Groeningen; André B P van Kuilenburg; A H Van Gennip; Godefridus J Peters
Pharmacokinetics of bolus 5-fluorouracil: relationship between dose, plasma concentrations, area-under-the-curve and toxicity.
Journal of chemotherapy (Florence, Italy) 2005;17(3):315-20.
2005: Olaf H Temmink; Michiel de Bruin; Elizabeth M Comijn; Masakazu Fukushima; Godefridus J Peters
Determinants of trifluorothymidine sensitivity and metabolism in colon and lung cancer cells.
Anti-cancer drugs 2005;16(3):285-92.
2005: Jennifer Sigmond; Godefridus J Peters
Pyrimidine and purine analogues, effects on cell cycle regulation and the role of cell cycle inhibitors to enhance their cytotoxicity.
Nucleosides, nucleotides & nucleic acids 2005;24(10-12):1997-2022.
2004: Kambiz Fotoohi; Gerrit Jansen; Yehuda G Assaraf; Lilah Rothem; Michal Stark; Ietje Kathmann; Jacek Gregorczyk; Godefridus J Peters; Freidoun Albertioni
Disparate mechanisms of antifolate resistance provoked by methotrexate and its metabolite 7-hydroxymethotrexate in leukemia cells: implications for efficacy of methotrexate therapy.
Blood 2004;104(13):4194-201.
2004: Isabelle Hubeek; Elena Litvinova; Godefridus J Peters; Richard Broekhuizen; Eric G Haarman; Dieuwke R Huismans; Jacqueline Cloos; Christian M Zwaan; Gudrun Fleischhack; Ursula Creutzig; G J L Kaspers
The effect of G-CSF on the in vitro cytotoxicity of cytarabine and fludarabine in the FLAG combination in pediatric acute myeloid leukemia.
International journal of oncology 2004;25(6):1823-9.
2004: Godefridus J Peters; Carolien H Smorenburg; Cees J van Groeningen
Prospective clinical trials using a pharmacogenetic/pharmacogenomic approach.
Journal of chemotherapy (Florence, Italy) 2004;16 Suppl 4():25-30.
2004: André Bergman; CM Kuiper; F Myhren; ML Sandvold; HR Hendriks; Godefridus J Peters
Antiproliferative activity and mechanism of action of fatty acid derivatives of arabinosylcytosine (ara-C) in leukemia and solid tumor cell lines.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1523-6.
2004: Isabelle Hubeek; Godefridus J Peters; A J F Broekhuizen; G J L Kaspers
Modulation of cytarabine induced cytotoxicity using novel deoxynucleoside analogs in the HL60 cell line.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1513-6.
2004: Jennifer Sigmond; Elizabeth M Comijn; J A E Kamphuis; Godefridus J Peters
Combinations of 5-fluorouracil with UCN-01 or staurosporine.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1503-6.
2004: Olaf H Temmink; Elizabeth M Comijn; Masakazu Fukushima; Godefridus J Peters
Intracellular thymidylate synthase inhibition by trifluorothymidine in FM3A cells.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1491-4.
2004: Michiel de Bruin; Toni Van Capel; Kees Smid; Kasper van der Born; Masakazu Fukushima; Klaas Hoekman; HERBERT PINEDO; Godefridus J Peters
Role of platelet derived endothelial cell growth factor/thymidine phosphorylase in fluoropyrimidine sensitivity and potential role of deoxyribose-1-phosphate.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1485-90.
2004: Paul Noordhuis; Ulbe Holwerda; J A M Van Laar; Clasina L Van der Wilt; Godefridus J Peters
A non-radioactive sensitive assay to measure 5-fluorouracil incorporation into DNA of solid tumors.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1481-4.
2004: Robert Mauritz; Wolfgang Schwabe; P Haeusler; Paul Noordhuis; Kees Smid; howard mcleod; Detlev Behnke; Cees J van Groeningen; Godefridus J Peters
Comparison of mRNA expression levels determined with TaqMan and competitive template RT-PCR.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1471-4.
2004: Jan Hendrik Hooijberg; Godefridus J Peters; G J L Kaspers; peter wielinga; Anjo J P Veerman; Rob Pieters; Gerrit Jansen
Online fluorescent method to assess BCRP/ABCG2 activity in suspension cells.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1451-4.
2004: Robert Mauritz; I J Beumer; S Marsh; howard mcleod; Kees Smid; Cees J van Groeningen; HERBERT PINEDO; Godefridus J Peters
Polymorphism of the thymidylate synthase gene and thymidylate synthase levels in colon cancer cell lines and different tissues of colorectal cancer patients.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1381-4.
2004: Michiel de Bruin; Kees Smid; M A van der Ent; Masakazu Fukushima; HERBERT PINEDO; Godefridus J Peters
Upregulation of platelet derived endothelial cell growth factor/thymidine phosphorylase by interferon alpha.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1367-70.
2004: Isabelle Hubeek; Godefridus J Peters; A J F Broekhuizen; Iannis Talianidis; Antoinette Y N Schouten-Van Meeteren; Elisabeth R van Wering; B Gibson; Ursula Creutzig; G J L Kaspers
Immunocytochemical detection of deoxycytidine kinase in pediatric malignancies in relation to in vitro cytarabine sensitivity.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1351-6.
2004: Jennifer Sigmond; Willem J P Loves; Judith R Kroep; Godefridus J Peters
Quantitative real time PCR of deoxycytidine kinase mRNA by Light Cycler PCR; in relation to enzyme activity.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1347-50.
2004: André Bergman; CM Kuiper; Paul Noordhuis; Kees Smid; Daphne Voorn; Elizabeth M Comijn; F Myhren; ML Sandvold; HR Hendriks; O Fodstad; K Breistøl; Godefridus J Peters
Antiproliferative activity and mechanism of action of fatty acid derivatives of gemcitabine in leukemia and solid tumor cell lines and in human xenografts.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1329-33.
2004: Godefridus J Peters; André B P van Kuilenburg; R A de Abreu
Purine and pyrimidine metabolism: new challenges.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1077-9.
2004: Michiel de Bruin; Godefridus J Peters; Ruud Oerlemans; Yehuda G Assaraf; Allan J Masterson; Auke D Adema; B A C Dijkmans; HERBERT PINEDO; Gerrit Jansen
Sulfasalazine down-regulates the expression of the angiogenic factors platelet-derived endothelial cell growth factor/thymidine phosphorylase and interleukin-8 in human monocytic-macrophage THP1 and U937 cells.
Molecular pharmacology 2004;66(4):1054-60.
2004: Jennifer Sigmond; Judith R Kroep; Willem J P Loves; Giovanni Codacci-Pisanelli; Godefridus J Peters
Quantitative real time PCR of deoxycytidine kinase mRNA by Light Cycler PCR in relation to enzyme activity and gemcitabine sensitivity.
Cancer letters 2004;213(2):173-9.
2004: Ashraf S Al-Madhoun; Clasina L Van der Wilt; Willem J P Loves; Jose Padron; Staffan Eriksson; Iannis Talianidis; Godefridus J Peters
Detection of an alternatively spliced form of deoxycytidine kinase mRNA in the 2'-2'-difluorodeoxycytidine (gemcitabine)-resistant human ovarian cancer cell line AG6000.
Biochemical pharmacology 2004;68(4):601-9.
2004: Paul Noordhuis; Ulbe Holwerda; Clasina L Van der Wilt; Cees J van Groeningen; Kees Smid; Sybren Meijer; HERBERT PINEDO; Godefridus J Peters
5-Fluorouracil incorporation into RNA and DNA in relation to thymidylate synthase inhibition of human colorectal cancers.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2004;15(7):1025-32.
2004: Jaap Haveman; Natasja Castro Kreder; Hans M Rodermond; Chris van Bree; N A P Franken; Lukas J A Stalpers; M Z Zdzienicka; Godefridus J Peters
Cellular response of X-ray sensitive hamster mutant cell lines to gemcitabine, cisplatin and 5-fluorouracil.
Oncology reports 2004;12(1):187-92.
2004: Godefridus J Peters; Paul Noordhuis; Cees J van Groeningen; Giuseppe Giaccone; Ulbe Holwerda; Daphne Voorn; Ad Schrijvers; Jan H Schornagel; Jos H Beijnen; Pierre Fumoleau; Jan H M Schellens
The effect of food on the pharmacokinetics of S-1 after single oral administration to patients with solid tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(12 Pt 1):4072-6.
2004: Michiel de Bruin; Toni Van Capel; Kees Smid; Masakazu Fukushima; Klaas Hoekman; HERBERT PINEDO; Godefridus J Peters
The effect of fluoropyrimidines with or without thymidine phosphorylase inhibitor on the expression of thymidine phosphorylase.
European journal of pharmacology 2004;491(2-3):93-9.
2004: Giuseppe Giaccone; J L González-Larriba; A T van Oosterom; R Alfonso; Egbert F Smit; M Martens; Godefridus J Peters; Wim J F van der Vijgh; R Smith; Steven D Averbuch; Abderrahim Fandi
Combination therapy with gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, gemcitabine and cisplatin in patients with advanced solid tumors.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2004;15(5):831-8.
2004: Gert Ossenkoppele; Wilfried J Graveland; Pieter Sonneveld; S M G J Daenen; Douwe H Biesma; Leo F Verdonck; M Ronald Schaafsma; Petra H M Westveer; Godefridus J Peters; Paul Noordhuis; Petra Muus; Dominik Selleslag; Bronno van der Holt; Michel Delforge; Bob Löwenberg; Gregor Verhoef
The value of fludarabine in addition to ARA-C and G-CSF in the treatment of patients with high-risk myelodysplastic syndromes and AML in elderly patients.
Blood 2004;103(8):2908-13.
2004: Jan Hendrik Hooijberg; Gerrit Jansen; Yehuda G Assaraf; Ietje Kathmann; Rob Pieters; Adrie C Laan; Anjo J P Veerman; G J L Kaspers; Godefridus J Peters
Folate concentration dependent transport activity of the Multidrug Resistance Protein 1 (ABCC1).
Biochemical pharmacology 2004;67(8):1541-8.
2004: Ettore De Berardinis; G Antonini; Godefridus J Peters; Willem J P Loves; K Van der Born; Giovanni Codacci-Pisanelli; Franco Di Silverio
Intravesical administration of gemcitabine in superficial bladder cancer: a phase I study with pharmacodynamic evaluation.
BJU international 2004;93(4):491-4.
2004: SM de Lange; Cees J van Groeningen; Judith R Kroep; Aart van Bochove; J F Snijders; Godefridus J Peters; HERBERT PINEDO; Giuseppe Giaccone
Phase II trial of cisplatin and gemcitabine in patients with advanced gastric cancer.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2004;15(3):484-8.
2004: André Bergman; CM Kuiper; Daphne Voorn; Elizabeth M Comijn; F Myhren; ML Sandvold; HR Hendriks; Godefridus J Peters
Antiproliferative activity and mechanism of action of fatty acid derivatives of arabinofuranosylcytosine in leukemia and solid tumor cell lines.
Biochemical pharmacology 2004;67(3):503-11.
2004: Judith R Kroep; HERBERT PINEDO; Giuseppe Giaccone; Aart van Bochove; Godefridus J Peters; Cees J van Groeningen
Phase II study of cisplatin preceding gemcitabine in patients with advanced oesophageal cancer.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2004;15(2):230-5.
2003: Jean M Sargent; Christine J Williamson; Isabelle Hubeek; Alena W Elgie; Colin G Taylor; Monique L den Boer; Godefridus J Peters; Gertjan L Kaspers
Aphidicolin decreases ex vivo resistance to cytosine arabinoside in childhood acute leukaemia.
Oncology reports 2003;10(6):2027-31.
2003: Ling-Zhi Wang; Boon Cher Goh; How-Sung Lee; Paul Noordhuis; Godefridus J Peters
An expedient assay for determination of gemcitabine and its metabolite in human plasma using isocratic ion-pair reversed-phase high-performance liquid chromatography.
Therapeutic drug monitoring 2003;25(5):552-7.
2003: Judith R Kroep; Cees J van Groeningen; Miguel A Cuesta; Mikael E Craanen; Otto S Hoekstra; Emile F I Comans; Elisabeth Bloemena; Corneline Hoekstra; Richard P Golding; Jos W R Twisk; Godefridus J Peters; HERBERT PINEDO; Adriaan A Lammertsma
Positron emission tomography using 2-deoxy-2-[18F]-fluoro-D-glucose for response monitoring in locally advanced gastroesophageal cancer; a comparison of different analytical methods.
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 2003;5(5):337-46.
2003: Jennifer Sigmond; Harold H J Backus; Dorine Wouters; Olaf H Temmink; Gerrit Jansen; Godefridus J Peters
Induction of resistance to the multitargeted antifolate Pemetrexed (ALIMTA) in WiDr human colon cancer cells is associated with thymidylate synthase overexpression.
Biochemical pharmacology 2003;66(3):431-8.
2003: Godefridus J Peters; Paul Noordhuis; André B P van Kuilenburg; Jan H Schornagel; Helen Gall; S L Turner; M S Swart; Daphne Voorn; A H Van Gennip; J Wanders; Ulbe Holwerda; Kees Smid; Giuseppe Giaccone; Pierre Fumoleau; Cees J van Groeningen
Pharmacokinetics of S-1, an oral formulation of ftorafur, oxonic acid and 5-chloro-2,4-dihydroxypyridine (molar ratio 1:0.4:1) in patients with solid tumors.
Cancer chemotherapy and pharmacology 2003;52(1):1-12.
2003: André Bergman; HERBERT PINEDO; Iannis Talianidis; Gijsbert Veerman; Willem J P Loves; Clasina L Van der Wilt; Godefridus J Peters
Increased sensitivity to gemcitabine of P-glycoprotein and multidrug resistance-associated protein-overexpressing human cancer cell lines.
British journal of cancer 2003;88(12):1963-70.
2003: Harold H J Backus; Dorine Wouters; Carlos G Ferreira; Viola M M van Houten; Ruud H Brakenhoff; HERBERT PINEDO; Godefridus J Peters
Thymidylate synthase inhibition triggers apoptosis via caspases-8 and -9 in both wild-type and mutant p53 colon cancer cell lines.
European journal of cancer (Oxford, England : 1990) 2003;39(9):1310-7.
2003: Katja Wosikowski; Elfi Biedermann; Benno Rattel; Norbert Breiter; Peter Jank; Roland Löser; Gerrit Jansen; Godefridus J Peters
In vitro and in vivo antitumor activity of methotrexate conjugated to human serum albumin in human cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(5):1917-26.
2003: Michiel de Bruin; Toni Van Capel; Kasper van der Born; Frank A E Kruyt; Masakazu Fukushima; Klaas Hoekman; HERBERT PINEDO; Godefridus J Peters
Role of platelet-derived endothelial cell growth factor/thymidine phosphorylase in fluoropyrimidine sensitivity.
British journal of cancer 2003;88(6):957-64.
2003: Clasina L Van der Wilt; Judith R Kroep; Willem J P Loves; Marianne G Rots; Cees J van Groeningen; G J L Kaspers; Godefridus J Peters
Expression of deoxycytidine kinase in leukaemic cells compared with solid tumour cell lines, liver metastases and normal liver.
European journal of cancer (Oxford, England : 1990) 2003;39(5):691-7.
2003: Jan Hendrik Hooijberg; Godefridus J Peters; Yehuda G Assaraf; Ietje Kathmann; David G Priest; Marlene A Bunni; Anjo J P Veerman; George L Scheffer; G J L Kaspers; Gerrit Jansen
The role of multidrug resistance proteins MRP1, MRP2 and MRP3 in cellular folate homeostasis.
Biochemical pharmacology 2003;65(5):765-71.
2003: Yehuda G Assaraf; Lilah Rothem; Jan Hendrik Hooijberg; Michal Stark; Ilan Ifergan; Ietje Kathmann; B A C Dijkmans; Godefridus J Peters; Gerrit Jansen
Loss of multidrug resistance protein 1 expression and folate efflux activity results in a highly concentrative folate transport in human leukemia cells.
The Journal of biological chemistry 2003;278(9):6680-6.
2003: Ronald W Stam; Monique L den Boer; Jules P P Meijerink; Marli E G Ebus; Godefridus J Peters; Paul Noordhuis; Gritta E Janka-Schaub; Scott A Armstrong; Stanley J Korsmeyer; Rob Pieters
Differential mRNA expression of Ara-C-metabolizing enzymes explains Ara-C sensitivity in MLL gene-rearranged infant acute lymphoblastic leukemia.
Blood 2003;101(4):1270-6.
2003: Michiel de Bruin; Kees Smid; Adrie C Laan; Paul Noordhuis; Masakazu Fukushima; Klaas Hoekman; HERBERT PINEDO; Godefridus J Peters
Rapid disappearance of deoxyribose-1-phosphate in platelet derived endothelial cell growth factor/thymidine phosphorylase overexpressing cells.
Biochemical and biophysical research communications 2003;301(3):675-9.
2003: Stephen P Ackland; Phillip Beale; Godefridus J Peters
Thymidylate synthase inhibitors.
Cancer chemotherapy and biological response modifiers 2003;21():1-28.
2003: Catharina J A Van Moorsel; Kees Smid; Daphne Voorn; André Bergman; HERBERT PINEDO; Godefridus J Peters
Effect of gemcitabine and cis-platinum combinations on ribonucleotide and deoxyribonucleotide pools in ovarian cancer cell lines.
International journal of oncology 2003;22(1):201-7.
2002: Chris van Bree; Natasja Castro Kreder; Willem J P Loves; N A P Franken; Godefridus J Peters; Jaap Haveman
Sensitivity to ionizing radiation and chemotherapeutic agents in gemcitabine-resistant human tumor cell lines.
International journal of radiation oncology, biology, physics 2002;54(1):237-44.
2002: Clasina L Van der Wilt; Kees Smid; Godefridus J Peters
Effects of antifolates on the binding of 5-fluoro-2'-deoxyuridine monophosphate to thymidylate synthase.
Biochemical pharmacology 2002;64(4):669-75.
2002: Godefridus J Peters; Harold H J Backus; S Freemantle; B van Triest; Giovanni Codacci-Pisanelli; Clasina L Van der Wilt; Kees Smid; J Lunec; A H Calvert; S Marsh; howard mcleod; Elisabeth Bloemena; Sybren Meijer; Gerrit Jansen; Cees J van Groeningen; HERBERT PINEDO
Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism.
Biochimica et biophysica acta 2002;1587(2-3):194-205.
2002: Bettina Gröschel; Andreas Kaufmann; Gerold Höver; Jindrich Cinatl; Hans Wilhelm Doerr; Paul Noordhuis; Willem J P Loves; Godefridus J Peters; Jindrich Cinatl
3'-Azido-2',3'-dideoxythymidine induced deficiency of thymidine kinases 1, 2 and deoxycytidine kinase in H9 T-lymphoid cells.
Biochemical pharmacology 2002;64(2):239-46.
2002: SM de Lange; Cees J van Groeningen; O W M Meijer; Miguel A Cuesta; J A Langendijk; J M G H van Riel; HERBERT PINEDO; Godefridus J Peters; Sybren Meijer; Ben Slotman; Giuseppe Giaccone
Gemcitabine-radiotherapy in patients with locally advanced pancreatic cancer.
European journal of cancer (Oxford, England : 1990) 2002;38(9):1212-7.
2002: NL Ramakers-van Woerden; Rob Pieters; Marianne G Rots; Christina H van Zantwijk; Paul Noordhuis; Berna Beverloo; Godefridus J Peters; Elisabeth R van Wering; B M Camitta; Ching-Hon Pui; Mary Relling; William Evans; Anjo J P Veerman
Infants with acute lymphoblastic leukemia: no evidence for high methotrexate resistance.
Leukemia 2002;16(5):949-51.
2002: Judith R Kroep; Willem J P Loves; Clasina L Van der Wilt; Enrique Alvarez; Iannis Talianidis; Epie Boven; Boudewijn J M Braakhuis; Cees J van Groeningen; HERBERT PINEDO; Godefridus J Peters
Pretreatment deoxycytidine kinase levels predict in vivo gemcitabine sensitivity.
Molecular cancer therapeutics 2002;1(6):371-6.
2002: Bart C Kuenen; Lee Rosen; Egbert F Smit; Mandy R N Parson; Marcel Levi; Rita Ruijter; Holger Huisman; Marc A Kedde; Paul Noordhuis; Wim J F van der Vijgh; Godefridus J Peters; Gillian F Cropp; Paul Scigalla; Klaas Hoekman; HERBERT PINEDO; Giuseppe Giaccone
Dose-finding and pharmacokinetic study of cisplatin, gemcitabine, and SU5416 in patients with solid tumors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2002;20(6):1657-67.
2002: Harold H J Backus; Cees J van Groeningen; Wim Vos; Danny F Dukers; Elisabeth Bloemena; Dorine Wouters; HERBERT PINEDO; Godefridus J Peters
Differential expression of cell cycle and apoptosis related proteins in colorectal mucosa, primary colon tumours, and liver metastases.
Journal of clinical pathology 2002;55(3):206-11.
2002: André Bergman; HERBERT PINEDO; Godefridus J Peters
Determinants of resistance to 2',2'-difluorodeoxycytidine (gemcitabine).
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2002;5(1):19-33.
2002: Robert Mauritz; Godefridus J Peters; David G Priest; Yehuda G Assaraf; Stavit Drori; Ietje Kathmann; Paul Noordhuis; Marlene A Bunni; Andre Rosowsky; Jan H Schornagel; HERBERT PINEDO; Gerrit Jansen
Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemia cells and their implications for folate homeostasis.
Biochemical pharmacology 2002;63(2):105-15.
2002: Stephen P Ackland; Stephen J Clarke; Phillip Beale; Godefridus J Peters
Thymidylate synthase inhibitors.
Cancer chemotherapy and biological response modifiers 2002;20():1-36.
2002: Giovanni Codacci-Pisanelli; Clasina L Van der Wilt; Kees Smid; Paul Noordhuis; Daphne Voorn; HERBERT PINEDO; Godefridus J Peters
High-dose 5-Fluorouracil with uridine-diphosphoglucose rescue increases thymidylate synthase inhibition but not 5-Fluorouracil incorporation into RNA in murine tumors.
Oncology 2002;62(4):363-70.
2002: Christian M Zwaan; G J L Kaspers; Rob Pieters; Karel Hählen; Gritta E Janka-Schaub; Christina H van Zantwijk; Dieuwke R Huismans; Esther de Vries; Marianne G Rots; Godefridus J Peters; Gerrit Jansen; Ursula Creutzig; Anjo J P Veerman
Different drug sensitivity profiles of acute myeloid and lymphoblastic leukemia and normal peripheral blood mononuclear cells in children with and without Down syndrome.
Blood 2002;99(1):245-51.
2002: N Castro Kreder; Chris van Bree; Godefridus J Peters; Willem J P Loves; Jaap Haveman
Enhanced levels of deoxycytidine kinase and thymidine kinase 1 and 2 after pulsed low dose rate irradiation as an adaptive response to radiation.
Oncology reports 2002;9(1):141-4.
2001: André B P van Kuilenburg; Alida E M Stroomer; Godefridus J Peters; Albert H van Gennip
Simultaneous determination of F-beta-alanine and beta-alanine in plasma and urine with dual-column reversed-phase high-performance liquid chromatography.
Journal of chromatography. B, Biomedical sciences and applications 2001;759(1):51-61.
2001: Harold H J Backus; Y M Rustum; Cees J van Groeningen; Godefridus J Peters
Chemotherapeutic strategies for treatment of colorectal cancer: present and future developments.
Clinical colorectal cancer 2001;1(2):121-7.
2001: Kees Smid; Catharina J A Van Moorsel; Paul Noordhuis; Daphne Voorn; Godefridus J Peters
Interference of gemcitabine triphosphate with the measurements of deoxynucleotides using an optimized DNA polymerase elongation assay.
International journal of oncology 2001;19(1):157-62.
2001: Harold H J Backus; J M G H van Riel; Cees J van Groeningen; Wim Vos; Danny F Dukers; Elisabeth Bloemena; Dorine Wouters; HERBERT PINEDO; Godefridus J Peters
Rb, mcl-1 and p53 expression correlate with clinical outcome in patients with liver metastases from colorectal cancer.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2001;12(6):779-85.
2001: André Bergman; B Munch-Petersen; P B Jensen; M Sehested; Gijsbert Veerman; Daphne Voorn; Kees Smid; HERBERT PINEDO; Godefridus J Peters
Collateral sensitivity to gemcitabine (2',2'-difluorodeoxycytidine) and cytosine arabinoside of daunorubicin- and VM-26-resistant variants of human small cell lung cancer cell lines.
Biochemical pharmacology 2001;61(11):1401-8.
2001: Clasina L Van der Wilt; Harold H J Backus; Kees Smid; L Comijn; Gijsbert Veerman; Dorine Wouters; Daphne Voorn; David G Priest; Marlene A Bunni; Fraser Mitchell; Ann L Jackman; Gerrit Jansen; Godefridus J Peters
Modulation of both endogenous folates and thymidine enhance the therapeutic efficacy of thymidylate synthase inhibitors.
Cancer research 2001;61(9):3675-81.
2001: André Bergman; HERBERT PINEDO; Godefridus J Peters
Steroids affect collateral sensitivity to gemcitabine of multidrug-resistant human lung cancer cells.
European journal of pharmacology 2001;416(1-2):19-24.
2001: Marianne G Rots; Rob Pieters; Gerrit Jansen; G J L Kaspers; Christina H van Zantwijk; Paul Noordhuis; Daphne Voorn; Elisabeth R van Wering; Ursula Creutzig; Anjo J P Veerman; Godefridus J Peters
A possible role for methotrexate in the treatment of childhood acute myeloid leukaemia, in particular for acute monocytic leukaemia.
European journal of cancer (Oxford, England : 1990) 2001;37(4):492-8.
2001: Harold H J Backus; Danny F Dukers; Cees J van Groeningen; Wim Vos; Elisabeth Bloemena; Dorine Wouters; J M G H van Riel; Kees Smid; Giuseppe Giaccone; HERBERT PINEDO; Godefridus J Peters
5-Fluorouracil induced Fas upregulation associated with apoptosis in liver metastases of colorectal cancer patients.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2001;12(2):209-16.
2000: Carlos G Ferreira; Simone W Span; Godefridus J Peters; Frank A E Kruyt; Giuseppe Giaccone
Chemotherapy triggers apoptosis in a caspase-8-dependent and mitochondria-controlled manner in the non-small cell lung cancer cell line NCI-H460.
Cancer research 2000;60(24):7133-41.
2000: Marianne G Rots; James Willey; Gerrit Jansen; Christina H van Zantwijk; Paul Noordhuis; Jeffrey P DeMuth; E Kuiper; Anjo J P Veerman; Rob Pieters; Godefridus J Peters
mRNA expression levels of methotrexate resistance-related proteins in childhood leukemia as determined by a standardized competitive template-based RT-PCR method.
Leukemia 2000;14(12):2166-75.
2000: Catharina J A Van Moorsel; HERBERT PINEDO; Kees Smid; Elizabeth M Comijn; Daphne Voorn; Gijsbert Veerman; B Lakerveld; Wim J F van der Vijgh; Giuseppe Giaccone; Pieter E Postmus; Godefridus J Peters
Schedule-dependent pharmacodynamic effects of gemcitabine and cisplatin in mice bearing Lewis lung murine non-small cell lung tumours.
European journal of cancer (Oxford, England : 1990) 2000;36(18):2420-9.
2000: Jose Padron; Clasina L Van der Wilt; Kees Smid; E Smitskamp-Wilms; Harold H J Backus; P E Pizao; Giuseppe Giaccone; Godefridus J Peters
The multilayered postconfluent cell culture as a model for drug screening.
Critical reviews in oncology/hematology 2000;36(2-3):141-57.
2000: Stavit Drori; Gerrit Jansen; Robert Mauritz; Godefridus J Peters; Yehuda G Assaraf
Clustering of mutations in the first transmembrane domain of the human reduced folate carrier in GW1843U89-resistant leukemia cells with impaired antifolate transport and augmented folate uptake.
The Journal of biological chemistry 2000;275(40):30855-63.
2000: André Bergman; Giuseppe Giaccone; Catharina J A Van Moorsel; Robert Mauritz; Paul Noordhuis; HERBERT PINEDO; Godefridus J Peters
Cross-resistance in the 2',2'-difluorodeoxycytidine (gemcitabine)-resistant human ovarian cancer cell line AG6000 to standard and investigational drugs.
European journal of cancer (Oxford, England : 1990) 2000;36(15):1974-83.
2000: Judith R Kroep; Giuseppe Giaccone; C Tolis; Daphne Voorn; Willem J P Loves; C J Groeningen; HERBERT PINEDO; Godefridus J Peters
Sequence dependent effect of paclitaxel on gemcitabine metabolism in relation to cell cycle and cytotoxicity in non-small-cell lung cancer cell lines.
British journal of cancer 2000;83(8):1069-76.
2000: Harold H J Backus; HERBERT PINEDO; Dorine Wouters; Jose Padron; N Molders; Clasina L Van der Wilt; Cees J van Groeningen; Gerrit Jansen; Godefridus J Peters
Folate depletion increases sensitivity of solid tumor cell lines to 5-fluorouracil and antifolates.
International journal of cancer. Journal international du cancer 2000;87(6):771-8.
2000: Marianne G Rots; Rob Pieters; G J L Kaspers; Anjo J P Veerman; Godefridus J Peters; Gerrit Jansen
Classification of ex vivo methotrexate resistance in acute lymphoblastic and myeloid leukaemia.
British journal of haematology 2000;110(4):791-800.
2000: Freek Van Muiswinkel; F M Riemers; Godefridus J Peters; M V LaFleur; D Siegel; C A M Jongenelen; Benjamin Drukarch
L-Dopa stimulates expression of the antioxidant enzyme NAD(P)H:quinone oxidoreductase (NQO) in cultured astroglial cells.
Free radical biology & medicine 2000;29(5):442-53.
2000: Godefridus J Peters; Clasina L Van der Wilt; Catharina J A Van Moorsel; Judith R Kroep; André Bergman; SP Ackland
Basis for effective combination cancer chemotherapy with antimetabolites.
Pharmacology & therapeutics 2000;87(2-3):227-53.
2000: Cees J van Groeningen; Godefridus J Peters; Jan H Schornagel; Helen Gall; Paul Noordhuis; M J de Vries; S L Turner; M S Swart; HERBERT PINEDO; A R Hanauske; Giuseppe Giaccone
Phase I clinical and pharmacokinetic study of oral S-1 in patients with advanced solid tumors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2000;18(14):2772-9.
2000: Marianne G Rots; Rob Pieters; Godefridus J Peters; Paul Noordhuis; Christina H van Zantwijk; Günter Henze; Gritta E Janka-Schaub; Anjo J P Veerman; Gerrit Jansen
Methotrexate resistance in relapsed childhood acute lymphoblastic leukaemia.
British journal of haematology 2000;109(3):629-34.
2000: B van Triest; B M Loftus; HERBERT PINEDO; Harold H J Backus; PS Schoenmakers; F Telleman; Thea M Tadema; G Wynne Aherne; Cees J van Groeningen; Frans A N Zoetmulder; B G Taal; P G Johnston; Godefridus J Peters
Thymidylate synthase expression in patients with colorectal carcinoma using a polyclonal thymidylate synthase antibody in comparison to the TS 106 monoclonal antibody.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2000;48(6):755-60.
2000: Godefridus J Peters; B van Triest; Harold H J Backus; CM Kuiper; Clasina L Van der Wilt; HERBERT PINEDO
Molecular downstream events and induction of thymidylate synthase in mutant and wild-type p53 colon cancer cell lines after treatment with 5-fluorouracil and the thymidylate synthase inhibitor raltitrexed.
European journal of cancer (Oxford, England : 1990) 2000;36(7):916-24.
2000: B van Triest; HERBERT PINEDO; Giuseppe Giaccone; Godefridus J Peters
Downstream molecular determinants of response to 5-fluorouracil and antifolate thymidylate synthase inhibitors.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2000;11(4):385-91.
2000: Catharina J A Van Moorsel; André Bergman; Gijsbert Veerman; Daphne Voorn; Veronique Ruiz van Haperen; Judith R Kroep; HERBERT PINEDO; Godefridus J Peters
Differential effects of gemcitabine on ribonucleotide pools of twenty-one solid tumour and leukaemia cell lines.
Biochimica et biophysica acta 2000;1474(1):5-12.
2000: B van Triest; HERBERT PINEDO; J L G Blaauwgeers; Paulus van Diest; PS Schoenmakers; Daphne Voorn; Kees Smid; Klaas Hoekman; H F Hoitsma; Godefridus J Peters
Prognostic role of thymidylate synthase, thymidine phosphorylase/platelet-derived endothelial cell growth factor, and proliferation markers in colorectal cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(3):1063-72.
2000: Harold H J Backus; Dorine Wouters; Clasina L Van der Wilt; CM Kuiper; Cees J van Groeningen; HERBERT PINEDO; Godefridus J Peters
Thymidylate synthase inhibition induces p53 dependent and independent cell death.
Advances in experimental medicine and biology 2000;486():303-6.
2000: Godefridus J Peters; Michiel de Bruin; Masakazu Fukushima; B van Triest; Klaas Hoekman; HERBERT PINEDO; SP Ackland
Thymidine phosphorylase in angiogenesis and drug resistance. Homology with platelet-derived endothelial cell growth factor.
Advances in experimental medicine and biology 2000;486():291-4.
2000: Clasina L Van der Wilt; Judith R Kroep; André Bergman; Willem J P Loves; E Alvarez; Iannis Talianidis; S Eriksson; Cees J van Groeningen; HERBERT PINEDO; Godefridus J Peters
The role of deoxycytidine kinase in gemcitabine cytotoxicity.
Advances in experimental medicine and biology 2000;486():287-90.
2000: Harold H J Backus; HERBERT PINEDO; Dorine Wouters; CM Kuiper; Gerrit Jansen; Cees J van Groeningen; Godefridus J Peters
Differences in the induction of DNA damage, cell cycle arrest, and cell death by 5-fluorouracil and antifolates.
Oncology research 2000;12(5):231-9.
2000: Carlos G Ferreira; C Tolis; Simone W Span; Godefridus J Peters; T van Lopik; A J Kummer; HERBERT PINEDO; Giuseppe Giaccone
Drug-induced apoptosis in lung cnacer cells is not mediated by the Fas/FasL (CD95/APO1) signaling pathway.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(1):203-12.
1999: Judith R Kroep; Godefridus J Peters; Catharina J A Van Moorsel; A Catik; Jan B Vermorken; HERBERT PINEDO; Cees J van Groeningen
Gemcitabine-cisplatin: a schedule finding study.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1999;10(12):1503-10.
1999: Gerrit Jansen; Godefridus J Peters; HERBERT PINEDO; David G Priest; Yehuda G Assaraf
Re: Folylpolyglutamyl synthetase gene transfer and glioma antifolate sensitivity in culture and in vivo.
Journal of the National Cancer Institute 1999;91(23):2047-50.
1999: Marianne G Rots; Rob Pieters; Godefridus J Peters; Christina H van Zantwijk; Robert Mauritz; Paul Noordhuis; James Willey; Karel Hählen; Ursula Creutzig; Gritta E Janka-Schaub; G J L Kaspers; Anjo J P Veerman; Gerrit Jansen
Circumvention of methotrexate resistance in childhood leukemia subtypes by rationally designed antifolates.
Blood 1999;94(9):3121-8.
1999: Godefridus J Peters; E Smitskamp-Wilms; Kees Smid; HERBERT PINEDO; Gerrit Jansen
Determinants of activity of the antifolate thymidylate synthase inhibitors Tomudex (ZD1694) and GW1843U89 against mono- and multilayered colon cancer cell lines under folate-restricted conditions.
Cancer research 1999;59(21):5529-35.
1999: B van Triest; Godefridus J Peters
Thymidylate synthase: a target for combination therapy and determinant of chemotherapeutic response in colorectal cancer.
Oncology 1999;57(3):179-94.
1999: Judith R Kroep; Giuseppe Giaccone; Daphne Voorn; Egbert F Smit; Jos H Beijnen; H Rosing; Catharina J A Van Moorsel; Cees J van Groeningen; Pieter E Postmus; HERBERT PINEDO; Godefridus J Peters
Gemcitabine and paclitaxel: pharmacokinetic and pharmacodynamic interactions in patients with non-small-cell lung cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1999;17(7):2190-7.
1999: Marcel Kool; M van der Linden; Marcel de Haas; George L Scheffer; J Marleen L de Vree; AJ Smith; Gerrit Jansen; Godefridus J Peters; N Ponne; Rik J Scheper; Ronald P J Oude Elferink; F Baas; Piet Borst
MRP3, an organic anion transporter able to transport anti-cancer drugs.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(12):6914-9.
1999: Jose Padron; Catharina J A Van Moorsel; André Bergman; E Smitskamp-Wilms; Clasina L Van der Wilt; Godefridus J Peters
Selective cell kill of the combination of gemcitabine and cisplatin in multilayered postconfluent tumor cell cultures.
Anti-cancer drugs 1999;10(5):445-52.
1999: Jan Hendrik Hooijberg; Henk J Broxterman; Marcel Kool; Yehuda G Assaraf; Godefridus J Peters; Paul Noordhuis; Rik J Scheper; Piet Borst; HERBERT PINEDO; Gerrit Jansen
Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2.
Cancer research 1999;59(11):2532-5.
1999: Catharina J A Van Moorsel; HERBERT PINEDO; Gijsbert Veerman; André Bergman; CM Kuiper; Jan B Vermorken; Wim J F van der Vijgh; Godefridus J Peters
Mechanisms of synergism between cisplatin and gemcitabine in ovarian and non-small-cell lung cancer cell lines.
British journal of cancer 1999;80(7):981-90.
1999: Catharina J A Van Moorsel; HERBERT PINEDO; Gijsbert Veerman; Jan B Vermorken; Pieter E Postmus; Godefridus J Peters
Scheduling of gemcitabine and cisplatin in Lewis lung tumour bearing mice.
European journal of cancer (Oxford, England : 1990) 1999;35(5):808-14.
1999: C Tolis; Godefridus J Peters; Carlos G Ferreira; HERBERT PINEDO; Giuseppe Giaccone
Cell cycle disturbances and apoptosis induced by topotecan and gemcitabine on human lung cancer cell lines.
European journal of cancer (Oxford, England : 1990) 1999;35(5):796-807.
1999: André Bergman; Gloria Cristalli; Sauro Vittori; J Wang; S Eriksson; Godefridus J Peters
Biological activity of 1-deazapurine nucleosides: role of deoxycytidine kinase?
Nucleosides & nucleotides 1999;18(4-5):897-8.
1999: Godefridus J Peters; Daphne Voorn; CM Kuiper; Clasina L Van der Wilt; Paul Noordhuis; Kees Smid; F Myhren; ML Sandvold; HR Hendriks
Cell specific cytotoxicity and structure-activity relationship of lipophilic 1-B-D-arabinofuranosylcytosine (ara-C) derivatives.
Nucleosides & nucleotides 1999;18(4-5):877-8.
1999: Catharina J A Van Moorsel; Judith R Kroep; HERBERT PINEDO; Gijsbert Veerman; Daphne Voorn; Pieter E Postmus; Jan B Vermorken; Cees J van Groeningen; Wim J F van der Vijgh; Godefridus J Peters
Pharmacokinetic schedule finding study of the combination of gemcitabine and cisplatin in patients with solid tumors.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1999;10(4):441-8.
1999: Gerrit Jansen; H Barr; Ietje Kathmann; Marlene A Bunni; David G Priest; Paul Noordhuis; Godefridus J Peters; Yehuda G Assaraf
Multiple mechanisms of resistance to polyglutamatable and lipophilic antifolates in mammalian cells: role of increased folylpolyglutamylation, expanded folate pools, and intralysosomal drug sequestration.
Molecular pharmacology 1999;55(4):761-9.
1999: B van Triest; HERBERT PINEDO; Yvette van Hensbergen; Kees Smid; F Telleman; PS Schoenmakers; Clasina L Van der Wilt; J A M Van Laar; Paul Noordhuis; Gerrit Jansen; Godefridus J Peters
Thymidylate synthase level as the main predictive parameter for sensitivity to 5-fluorouracil, but not for folate-based thymidylate synthase inhibitors, in 13 nonselected colon cancer cell lines.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(3):643-54.
1999: Marianne G Rots; Rob Pieters; Godefridus J Peters; Paul Noordhuis; Christina H van Zantwijk; G J L Kaspers; Karel Hählen; Ursula Creutzig; Anjo J P Veerman; Gerrit Jansen
Role of folylpolyglutamate synthetase and folylpolyglutamate hydrolase in methotrexate accumulation and polyglutamylation in childhood leukemia.
Blood 1999;93(5):1677-83.
1999: Catharina J A Van Moorsel; HERBERT PINEDO; Gijsbert Veerman; A Guechev; Kees Smid; Willem J P Loves; Jan B Vermorken; Pieter E Postmus; Godefridus J Peters
Combination chemotherapy studies with gemcitabine and etoposide in non-small cell lung and ovarian cancer cell lines.
Biochemical pharmacology 1999;57(4):407-15.
1999: André Bergman; HERBERT PINEDO; A P M Jongsma; M Brouwer; Veronique Ruiz van Haperen; Gijsbert Veerman; A Leyva; S Eriksson; Godefridus J Peters
Decreased resistance to gemcitabine (2',2'-difluorodeoxycitidine) of cytosine arabinoside-resistant myeloblastic murine and rat leukemia cell lines: role of altered activity and substrate specificity of deoxycytidine kinase.
Biochemical pharmacology 1999;57(4):397-406.
1999: Marianne G Rots; Rob Pieters; G J L Kaspers; Christina H van Zantwijk; Paul Noordhuis; Robert Mauritz; Anjo J P Veerman; Gerrit Jansen; Godefridus J Peters
Differential methotrexate resistance in childhood T- versus common/preB-acute lymphoblastic leukemia can be measured by an in situ thymidylate synthase inhibition assay, but not by the MTT assay.
Blood 1999;93(3):1067-74.
1999: Clasina L Van der Wilt; CM Kuiper; Godefridus J Peters
Combination studies of antifolates with 5-fluorouracil in colon cancer cell lines.
Oncology research 1999;11(8):383-91.
1999: Judith R Kroep; HERBERT PINEDO; Cees J van Groeningen; Godefridus J Peters
Experimental drugs and drug combinations in pancreatic cancer.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1999;10 Suppl 4():234-8.
1998: Gerrit Jansen; Robert Mauritz; Stavit Drori; Hannah Sprecher; Ietje Kathmann; Marlene A Bunni; David G Priest; Paul Noordhuis; Jan H Schornagel; HERBERT PINEDO; Godefridus J Peters; Yehuda G Assaraf
A structurally altered human reduced folate carrier with increased folic acid transport mediates a novel mechanism of antifolate resistance.
The Journal of biological chemistry 1998;273(46):30189-98.
1998: Robert Mauritz; M W Bekkenk; Marianne G Rots; Rob Pieters; E Mini; Christina H van Zantwijk; Anjo J P Veerman; Godefridus J Peters; Gerrit Jansen
Ex vivo activity of methotrexate versus novel antifolate inhibitors of dihydrofolate reductase and thymidylate synthase against childhood leukemia cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(10):2399-410.
1998: E Smitskamp-Wilms; HERBERT PINEDO; Gijsbert Veerman; Veronique Ruiz van Haperen; Godefridus J Peters
Postconfluent multilayered cell line cultures for selective screening of gemcitabine.
European journal of cancer (Oxford, England : 1990) 1998;34(6):921-6.
1998: A Freund; Joachim Boos; S Harkin; MH Schultze-Mosgau; G Veerman; Godefridus J Peters; Andreas J Gescher
Augmentation of 1-beta-D-arabinofuranosylcytosine (Ara-C) cytotoxicity in leukaemia cells by co-administration with antisignalling drugs.
European journal of cancer (Oxford, England : 1990) 1998;34(6):895-901.
1998: Alena W Elgie; Jean M Sargent; P Alton; Godefridus J Peters; P Noordhuis; Christine J Williamson; Colin G Taylor
Modulation of resistance to ara-C by bryostatin in fresh blast cells from patients with AML.
Leukemia research 1998;22(4):373-8.
1998: J A M Van Laar; Y M Rustum; SP Ackland; Cees J van Groeningen; Godefridus J Peters
Comparison of 5-fluoro-2'-deoxyuridine with 5-fluorouracil and their role in the treatment of colorectal cancer.
European journal of cancer (Oxford, England : 1990) 1998;34(3):296-306.
1998: André B P van Kuilenburg; Robert Poorter; Godefridus J Peters; Albert H van Gennip; Henk Van Lenthe; Alida E M Stroomer; Kees Smid; Paul Noordhuis; P J M Bakker; Cindy Veenhof
No circadian variation of dihydropyrimidine dehydrogenase, uridine phosphorylase, beta-alanine, and 5-fluorouracil during continuous infusion of 5-fluorouracil.
Advances in experimental medicine and biology 1998;431():811-6.
1998: Godefridus J Peters; CM Kuiper; B van Triest; Harold H J Backus; Clasina L Van der Wilt; J A M Van Laar; Gerrit Jansen; Cees J van Groeningen; HERBERT PINEDO
Determinants of the therapeutic efficacy of thymidylate synthase inhibitors.
Advances in experimental medicine and biology 1998;431():699-704.
1998: Catharina J A Van Moorsel; Gijsbert Veerman; Veronique Ruiz van Haperen; André Bergman; P B Jensen; M Sehested; Godefridus J Peters
Differential effects of gemcitabine on nucleotide pools of 19 solid tumor cell lines.
Advances in experimental medicine and biology 1998;431():661-5.
1998: Judith R Kroep; Catharina J A Van Moorsel; Gijsbert Veerman; Daphne Voorn; R M Schultz; J F Worzalla; LEE TANZER; Ronald L Merriman; HERBERT PINEDO; Godefridus J Peters
Role of deoxycytidine kinase (dCK), thymidine kinase 2 (TK2), and deoxycytidine deaminase (dCDA) in the antitumor activity of gemcitabine (dFdC).
Advances in experimental medicine and biology 1998;431():657-60.
1998: Clasina L Van der Wilt; Kees Smid; Gijsbert Veerman; Godefridus J Peters
The role of thymidine kinase activity in murine colon tumours treated with 5-fluorouracil.
Advances in experimental medicine and biology 1998;431():653-6.
1998: Veronique Ruiz van Haperen; Gijsbert Veerman; Catharina J A Van Moorsel; Godefridus J Peters
Induction of in vivo resistance against gemcitabine (dFdC, 2',2'-difluoro-deoxycytidine).
Advances in experimental medicine and biology 1998;431():637-40.
1998: Godefridus J Peters; Cees J van Groeningen; HERBERT PINEDO
Dihydropyrimidine dehydrogenase in livers from mouse and rat, and in human liver, colon tumors, and mucosa in relation to anabolism of 5-fluorouracil.
Advances in experimental medicine and biology 1998;431():633-6.
1998: André Bergman; HERBERT PINEDO; Gijsbert Veerman; CM Kuiper; Godefridus J Peters
Increased sensitivity to gemcitabine of P-gP and MRP overexpressing human non-small cell lung cancer cell lines.
Advances in experimental medicine and biology 1998;431():591-4.
1998: André Bergman; HERBERT PINEDO; Veronique Ruiz van Haperen; Gijsbert Veerman; CM Kuiper; Godefridus J Peters
Cross-resistance of the gemcitabine resistant human ovarian cancer cell line AG6000 to standard and investigational drugs.
Advances in experimental medicine and biology 1998;431():587-90.
1998: Catharina J A Van Moorsel; Gijsbert Veerman; Jan B Vermorken; Daphne Voorn; Judith R Kroep; André Bergman; HERBERT PINEDO; Godefridus J Peters
Mechanisms of synergism between gemcitabine and cisplatin.
Advances in experimental medicine and biology 1998;431():581-5.
1997: B van Triest; HERBERT PINEDO; F Telleman; Clasina L Van der Wilt; Gerrit Jansen; Godefridus J Peters
Cross-resistance to antifolates in multidrug resistant cell lines with P-glycoprotein or multidrug resistance protein expression.
Biochemical pharmacology 1997;53(12):1855-66.
1997: Catharina J A Van Moorsel; Gijsbert Veerman; André Bergman; A Guechev; Jan B Vermorken; Pieter E Postmus; Godefridus J Peters
Combination chemotherapy studies with gemcitabine.
Seminars in oncology 1997;24(2 Suppl 7):S7-17-S7-23.
1997: Giovanni Codacci-Pisanelli; J Kralovanszky; Clasina L Van der Wilt; Paul Noordhuis; JR Colofiore; D S Martin; Fabrizio Franchi; Godefridus J Peters
Modulation of 5-fluorouracil in mice using uridine diphosphoglucose.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(2):309-15.
1997: CH Langeveld; C A M Jongenelen; J W Theeuwes; J P Baak; Jan J Heimans; JC Stoof; Godefridus J Peters
The antiproliferative effect of 8-chloro-adenosine, an active metabolite of 8-chloro-cyclic adenosine monophosphate, and disturbances in nucleic acid synthesis and cell cycle kinetics.
Biochemical pharmacology 1997;53(2):141-8.
1997: Clasina L Van der Wilt; Cees J van Groeningen; HERBERT PINEDO; Kees Smid; Klaas Hoekman; Sybren Meijer; Godefridus J Peters
5-fluorouracil/leucovorin-induced inhibition of thymidylate synthase in normal tissues of mouse and man.
Journal of cancer research and clinical oncology 1997;123(11-12):595-601.
1997: Gerrit Jansen; Robert Mauritz; Yehuda G Assaraf; Hannah Sprecher; Stavit Drori; Ietje Kathmann; G R Westerhof; David G Priest; Marlene A Bunni; HERBERT PINEDO; Jan H Schornagel; Godefridus J Peters
Regulation of carrier-mediated transport of folates and antifolates in methotrexate-sensitive and-resistant leukemia cells.
Advances in enzyme regulation 1997;37():59-76.
1996: Godefridus J Peters; Veronique Ruiz van Haperen; André Bergman; Gijsbert Veerman; E Smitskamp-Wilms; Catharina J A Van Moorsel; CM Kuiper; Boudewijn J M Braakhuis
Preclinical combination therapy with gemcitabine and mechanisms of resistance.
Seminars in oncology 1996;23(5 Suppl 10):16-24.
1996: J A M Van Laar; Clasina L Van der Wilt; Y M Rustum; Paul Noordhuis; Kees Smid; HERBERT PINEDO; Godefridus J Peters
Therapeutic efficacy of fluoropyrimidines depends on the duration of thymidylate synthase inhibition in the murine colon 26-B carcinoma tumor model.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(8):1327-33.
1996: Gerard W M Visser; Clasina L Van der Wilt; R Wedzinga; Godefridus J Peters; J D M Herscheid
18F-radiopharmacokinetics of [18F]-5-fluorouracil in a mouse bearing two colon tumors with a different 5-fluorouracil sensitivity: a study for a correlation with oncological results.
Nuclear medicine and biology 1996;23(3):333-42.
1996: E Smitskamp-Wilms; H R Hendriks; Godefridus J Peters
Development, pharmacology, role of DT-diaphorase and prospects of the indoloquinone EO9.
General pharmacology 1996;27(3):421-9.
1996: André Bergman; Veronique Ruiz van Haperen; Gijsbert Veerman; CM Kuiper; Godefridus J Peters
Synergistic interaction between cisplatin and gemcitabine in vitro.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(3):521-30.
1996: Paul Noordhuis; K M Kazemier; G J Kasperrs; Godefridus J Peters
Modulation of metabolism and cytotoxicity of cytosine arabinoside with N-(phosphon)-acetyl-L-aspartate in human leukemic blast cells and cell lines.
Leukemia research 1996;20(2):127-34.
1996: J A M Van Laar; Y M Rustum; Clasina L Van der Wilt; Kees Smid; CM Kuiper; HERBERT PINEDO; Godefridus J Peters
Tumor size and origin determine the antitumor activity of cisplatin or 5-fluorouracil and its modulation by leucovorin in murine colon carcinomas.
Cancer chemotherapy and pharmacology 1996;39(1-2):79-89.
1996: Gijsbert Veerman; Veronique Ruiz van Haperen; Jan B Vermorken; Paul Noordhuis; Boudewijn J M Braakhuis; HERBERT PINEDO; Godefridus J Peters
Antitumor activity of prolonged as compared with bolus administration of 2',2'-difluorodeoxycytidine in vivo against murine colon tumors.
Cancer chemotherapy and pharmacology 1996;38(4):335-42.
1995: Boudewijn J M Braakhuis; Veronique Ruiz van Haperen; MJ Welters; Godefridus J Peters
Schedule-dependent therapeutic efficacy of the combination of gemcitabine and cisplatin in head and neck cancer xenografts.
European journal of cancer (Oxford, England : 1990) 1995;31A(13-14):2335-40.
1995: Godefridus J Peters; Clasina L Van der Wilt
Thymidylate synthase as a target in cancer chemotherapy.
Biochemical Society transactions 1995;23(4):884-8.
1995: Godefridus J Peters; Paul Noordhuis; A Komissarov; U Holwerda; M Kok; J A M Van Laar; Clasina L Van der Wilt; V Van Groeningen; HERBERT PINEDO
Quantification of 5-fluorouracil incorporation into RNA of human and murine tumors as measured with a sensitive gas chromatography-mass spectrometry assay.
Analytical biochemistry 1995;231(1):157-63.
1995: E Smitskamp-Wilms; Giuseppe Giaccone; HERBERT PINEDO; B F van der Laan; Godefridus J Peters
DT-diaphorase activity in normal and neoplastic human tissues; an indicator for sensitivity to bioreductive agents?
British journal of cancer 1995;72(4):917-21.
1995: G R Westerhof; S Rijnboutt; Jan H Schornagel; HERBERT PINEDO; Godefridus J Peters; Gerrit Jansen
Functional activity of the reduced folate carrier in KB, MA104, and IGROV-I cells expressing folate-binding protein.
Cancer research 1995;55(17):3795-802.
1995: G R Westerhof; Jan H Schornagel; Ietje Kathmann; A L Jackman; Andre Rosowsky; R A Forsch; J B Hynes; F T Boyle; Godefridus J Peters; HERBERT PINEDO
Carrier- and receptor-mediated transport of folate antagonists targeting folate-dependent enzymes: correlates of molecular-structure and biological activity.
Molecular pharmacology 1995;48(3):459-71.
1995: Godefridus J Peters; André Bergman; Veronique Ruiz van Haperen; Gijsbert Veerman; CM Kuiper; Boudewijn J M Braakhuis
Interaction between cisplatin and gemcitabine in vitro and in vivo.
Seminars in oncology 1995;22(4 Suppl 11):72-9.
1995: Boudewijn J M Braakhuis; Veronique Ruiz van Haperen; Epie Boven; Gijsbert Veerman; Godefridus J Peters
Schedule-dependent antitumor effect of gemcitabine in in vivo model system.
Seminars in oncology 1995;22(4 Suppl 11):42-6.
1995: Veronique Ruiz van Haperen; Gijsbert Veerman; S Eriksson; A P Stegmann; Godefridus J Peters
Induction of resistance to 2',2'-difluorodeoxycytidine in the human ovarian cancer cell line A2780.
Seminars in oncology 1995;22(4 Suppl 11):35-41.
1995: Godefridus J Peters; Clasina L Van der Wilt; B van Triest; Giovanni Codacci-Pisanelli; P G Johnston; Cees J van Groeningen; HERBERT PINEDO
Thymidylate synthase and drug resistance.
European journal of cancer (Oxford, England : 1990) 1995;31A(7-8):1299-305.
1995: Clasina L Van der Wilt; Boudewijn J M Braakhuis; HERBERT PINEDO; M De Jong; Kees Smid; Godefridus J Peters
Addition of leucovorin in modulation of 5-fluorouracil with methotrexate: potentiating or reversing effect?
International journal of cancer. Journal international du cancer 1995;61(5):672-8.
1995: Clasina L Van der Wilt; J Cloos; M de Jong; HERBERT PINEDO; Godefridus J Peters
Screening of colon tumor cells and tissues for folylpolyglutamate synthetase activity.
Oncology research 1995;7(6):317-21.
1995: Clasina L Van der Wilt; A Marinelli; HERBERT PINEDO; J Cloos; Kees Smid; C J van de Velde; Godefridus J Peters
The effect of different routes of administration of 5-fluorouracil on thymidylate synthase inhibition in the rat.
European journal of cancer (Oxford, England : 1990) 1995;31A(5):754-60.
1995: Godefridus J Peters; Wim J F van der Vijgh
Protection of normal tissues from the cytotoxic effects of chemotherapy and radiation by amifostine (WR-2721): preclinical aspects.
European journal of cancer (Oxford, England : 1990) 1995;31A Suppl 1():S1-7.
1995: Giovanni Codacci-Pisanelli; Clasina L Van der Wilt; HERBERT PINEDO; Fabrizio Franchi; Paul Noordhuis; Boudewijn J M Braakhuis; J A M Van Laar; Godefridus J Peters
Antitumour activity, toxicity and inhibition of thymidylate synthase of prolonged administration of 5-fluorouracil in mice.
European journal of cancer (Oxford, England : 1990) 1995;31A(9):1517-25.
1995: R L Poorter; Godefridus J Peters; P J M Bakker; Carlo W Taat; D M Biermans-van Leeuwe; Giovanni Codacci-Pisanelli; Paul Noordhuis; J Oosting; Cindy Veenhof
Intermittent continuous infusion of 5-fluorouracil and low dose oral leucovorin in patients with gastrointestinal cancer: relationship between plasma concentrations and clinical parameters.
European journal of cancer (Oxford, England : 1990) 1995;31A(9):1465-70.
1994: Veronique Ruiz van Haperen; Gijsbert Veerman; Epie Boven; Paul Noordhuis; Jan B Vermorken; Godefridus J Peters
Schedule dependence of sensitivity to 2',2'-difluorodeoxycytidine (Gemcitabine) in relation to accumulation and retention of its triphosphate in solid tumour cell lines and solid tumours.
Biochemical pharmacology 1994;48(7):1327-39.
1994: Wim J F van der Vijgh; Godefridus J Peters
Protection of normal tissues from the cytotoxic effects of chemotherapy and radiation by amifostine (Ethyol): preclinical aspects.
Seminars in oncology 1994;21(5 Suppl 11):2-7.
1994: P E Pizao; E Smitskamp-Wilms; J van Ark-Otte; Jos H Beijnen; Godefridus J Peters; HERBERT PINEDO; Giuseppe Giaccone
Antiproliferative activity of the topoisomerase I inhibitors topotecan and camptothecin, on sub- and postconfluent tumor cell cultures.
Biochemical pharmacology 1994;48(6):1145-54.
1994: Veronique Ruiz van Haperen; Gijsbert Veerman; S Eriksson; Epie Boven; A P Stegmann; M Hermsen; Jan B Vermorken; HERBERT PINEDO; Godefridus J Peters
Development and molecular characterization of a 2',2'-difluorodeoxycytidine-resistant variant of the human ovarian carcinoma cell line A2780.
Cancer research 1994;54(15):4138-43.
1994: R Lopez-Lopez; C H Langeveld; P E Pizao; R E van Rijswijk; John Wagstaff; HERBERT PINEDO; Godefridus J Peters
Effect of suramin on adenylate cyclase and protein kinase C.
Anti-cancer drug design 1994;9(4):279-90.
1994: E Smitskamp-Wilms; Godefridus J Peters; HERBERT PINEDO; J van Ark-Otte; Giuseppe Giaccone
Chemosensitivity to the indoloquinone EO9 is correlated with DT-diaphorase activity and its gene expression.
Biochemical pharmacology 1994;47(8):1325-32.
1994: Veronique Ruiz van Haperen; Godefridus J Peters
New targets for pyrimidine antimetabolites for the treatment of solid tumours. 2: Deoxycytidine kinase.
Pharmacy world & science : PWS 1994;16(2):104-12.
1994: Clasina L Van der Wilt; Godefridus J Peters
New targets for pyrimidine antimetabolites in the treatment of solid tumours. 1: Thymidylate synthase.
Pharmacy world & science : PWS 1994;16(2):84-103.
1994: T W De Graaf; Godefridus J Peters; Willem Van Dijk
Antimetabolite-induced increases in the invasive capacity of murine leukaemia L1210 cells.
Clinical & experimental metastasis 1994;12(2):134-42.
1994: M Treskes; Epie Boven; A A van de Loosdrecht; J F Wijffels; J Cloos; Godefridus J Peters; HERBERT PINEDO; Wim J F van der Vijgh
Effects of the modulating agent WR2721 on myelotoxicity and antitumour activity in carboplatin-treated mice.
European journal of cancer (Oxford, England : 1990) 1994;30A(2):183-7.
1994: R Lopez; Godefridus J Peters; E Smitskamp-Wilms; J A Virizuela; J van Ark-Otte; HERBERT PINEDO; Giuseppe Giaccone
In vitro sequence-dependent synergistic effect of suramin and camptothecin.
European journal of cancer (Oxford, England : 1990) 1994;30A(11):1670-4.
1994: R Lopez Lopez; R E van Rijswijk; John Wagstaff; HERBERT PINEDO; Godefridus J Peters
The synergistic and antagonistic effects of cytotoxic and biological agents on the in vitro antitumour effects of suramin.
European journal of cancer (Oxford, England : 1990) 1994;30A(10):1545-9.
1994: Godefridus J Peters; C L van der Wilt; C J van Groeningen
Predictive value of thymidylate synthase and dihydropyrimidine dehydrogenase.
European journal of cancer (Oxford, England : 1990) 1994;30A(10):1408-11.
1994: Godefridus J Peters
Therapy related disturbances in nucleotides in cancer cells.
Advances in experimental medicine and biology 1994;370():95-107.
1994: D C van Oostveen; Rob Pieters; Godefridus J Peters; Anjo J P Veerman
Purine nucleotide interconversion enzymes in childhood leukemia: relation with cell cycle and clinical outcome.
Advances in experimental medicine and biology 1994;370():209-12.
1994: B van Triest; F Telleman; HERBERT PINEDO; Clasina L Van der Wilt; Godefridus J Peters
Cross-resistance to thymidylate synthase inhibitors in P-glycoprotein and non-P-glycoprotein cell lines.
Advances in experimental medicine and biology 1994;370():189-93.
1994: André Bergman; Veronique Ruiz van Haperen; Gijsbert Veerman; CM Kuiper; Godefridus J Peters
Synergistic interaction between cisplatin and gemcitabine in ovarian and colon cancer cell lines.
Advances in experimental medicine and biology 1994;370():139-43.
1994: Clasina L Van der Wilt; J A M Van Laar; Kees Smid; Y M Rustum; Godefridus J Peters
Comparison of 5-fluoro-2'-deoxyuridine and 5-fluorouracil in the treatment of murine colon cancer; effects on thymidylate synthase.
Advances in experimental medicine and biology 1994;370():109-14.
1993: Boudewijn J M Braakhuis; G Jansen; Paul Noordhuis; A Kegel; Godefridus J Peters
Importance of pharmacodynamics in the in vitro antiproliferative activity of the antifolates methotrexate and 10-ethyl-10-deazaaminopterin against human head and neck squamous cell carcinoma.
Biochemical pharmacology 1993;46(12):2155-61.
1993: Clasina L Van der Wilt; Gerard W M Visser; Boudewijn J M Braakhuis; R Wedzinga; Paul Noordhuis; Kees Smid; Godefridus J Peters
In vitro antitumour activity of cis- and trans-5-fluoro-5,6-dihydro-6-alkoxy-uracils; effects on thymidylate synthesis.
British journal of cancer 1993;68(4):702-7.
1993: H T Edzes; Godefridus J Peters; Paul Noordhuis; J B Vermorken
Determination of the antimetabolite Gemcitabine (2',2'-difluoro-2'-deoxycytidine) and of 2',2'-difluoro-2'-deoxyuridine by 19F nuclear magnetic resonance spectroscopy.
Analytical biochemistry 1993;214(1):25-30.
1993: Veronique Ruiz van Haperen; Gijsbert Veerman; Jan B Vermorken; Godefridus J Peters
2',2'-Difluoro-deoxycytidine (gemcitabine) incorporation into RNA and DNA of tumour cell lines.
Biochemical pharmacology 1993;46(4):762-6.
1993: Godefridus J Peters; E Laurensse; H W Steinbusch; J De Vente; Kees Smid; Clasina L Van der Wilt; HERBERT PINEDO
Development, characterization and application of an antibody against 5-fluoro-2'deoxyuridine-5'monophosphate, the active metabolite of 5-fluorouracil.
Anticancer research 1993;13(4):835-9.
1993: Godefridus J Peters; M Wets; Y P Keepers; R Oskam; J van Ark-Otte; Paul Noordhuis; Kees Smid; HERBERT PINEDO
Transformation of mouse fibroblasts with the oncogenes H-ras OR trk is associated with pronounced changes in drug sensitivity and metabolism.
International journal of cancer. Journal international du cancer 1993;54(3):450-5.
1993: Cees J van Groeningen; Godefridus J Peters; HERBERT PINEDO
Reversal of 5-fluorouracil-induced toxicity by oral administration of uridine.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1993;4(4):317-20.
1993: Godefridus J Peters; Y M Rustum
Novel approaches to selective treatments of human solid tumors: laboratory and clinical correlation.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1993;4(4):277-81.
1993: Clasina L Van der Wilt; HERBERT PINEDO; M de Jong; Godefridus J Peters
Effect of folate diastereoisomers on the binding of 5-fluoro-2'-deoxyuridine-5'-monophosphate to thymidylate synthase.
Biochemical pharmacology 1993;45(5):1177-9.
1993: Godefridus J Peters; Jan Lankelma; R M Kok; Paul Noordhuis; Cees J van Groeningen; Clasina L Van der Wilt; S Meyer; HERBERT PINEDO
Prolonged retention of high concentrations of 5-fluorouracil in human and murine tumors as compared with plasma.
Cancer chemotherapy and pharmacology 1993;31(4):269-76.
1993: T W De Graaf; S S Slot; Godefridus J Peters; Willem Van Dijk
Changes in glycosylation of L1210 cells after exposure to various antimetabolites.
European journal of cancer (Oxford, England : 1990) 1993;29A(12):1760-5.
1993: Godefridus J Peters; Clasina L Van der Wilt; J Cloos; HERBERT PINEDO
Development of a simple folylpolyglutamate synthetase assay in tissues and cell lines.
Advances in experimental medicine and biology 1993;338():651-4.
1993: Godefridus J Peters; K Hoekman; Cees J van Groeningen; Clasina L Van der Wilt; Kees Smid; S Meijer; HERBERT PINEDO
Potentiation of 5-fluorouracil induced inhibition of thymidylate synthase in human colon tumors by leucovorin is dose dependent.
Advances in experimental medicine and biology 1993;338():613-6.
1993: C L van der Wilt; M de Jong; B J Braakhuis; HERBERT PINEDO; Godefridus J Peters
The interval between methotrexate and leucovorin determines the efficacy of 5-fluorouracil modulation in vitro and in vivo.
Advances in experimental medicine and biology 1993;338():609-12.
1993: Veronique Ruiz van Haperen; Gijsbert Veerman; Boudewijn J M Braakhuis; Jan B Vermorken; Epie Boven; A Leyva; Godefridus J Peters
Deoxycytidine kinase and deoxycytidine deaminase activities in human tumour xenografts.
European journal of cancer (Oxford, England : 1990) 1993;29A(15):2132-7.
1993: P E Pizao; Godefridus J Peters; J van Ark-Otte; L A Smets; E Smitskamp-Wilms; B Winograd; HERBERT PINEDO; Giuseppe Giaccone
Cytotoxic effects of anticancer agents on subconfluent and multilayered postconfluent cultures.
European journal of cancer (Oxford, England : 1990) 1993;29A(11):1566-73.
1993: Godefridus J Peters; Giovanni Codacci-Pisanelli; Clasina L Van der Wilt; J A M Van Laar; Kees Smid; Paul Noordhuis; HERBERT PINEDO
Comparison of continuous infusions and bolus injections of 5-fluorouracil with or without leucovorin: implications for inhibition of thymidylate synthase.
Advances in experimental medicine and biology 1993;339():9-20; discussion 21.
1993: Godefridus J Peters; Jan Schornagel; G A Milano
Clinical pharmacokinetics of anti-metabolites.
Cancer surveys 1993;17():123-56.
1993: Clasina L Van der Wilt; Kees Smid; G W Aherne; HERBERT PINEDO; Godefridus J Peters
Evaluation of immunohistochemical staining and activity of thymidylate synthase in cell lines.
Advances in experimental medicine and biology 1993;338():605-8.
1992: P E Pizao; D M Lyaruu; Godefridus J Peters; J van Ark-Otte; B Winograd; Giuseppe Giaccone; HERBERT PINEDO
Growth, morphology and chemosensitivity studies on postconfluent cells cultured in 'V'-bottomed microtiter plates.
British journal of cancer 1992;66(4):660-5.
1992: Clasina L Van der Wilt; HERBERT PINEDO; Kees Smid; Godefridus J Peters
Elevation of thymidylate synthase following 5-fluorouracil treatment is prevented by the addition of leucovorin in murine colon tumors.
Cancer research 1992;52(18):4922-8.
1992: Rob Pieters; D R Huismans; A H Loonen; Godefridus J Peters; Karel Hählen; Anna van der Does-van den Berg; Elisabeth R van Wering; Anjo J P Veerman
Relation of 5'-nucleotidase and phosphatase activities with immunophenotype, drug resistance and clinical prognosis in childhood leukemia.
Leukemia research 1992;16(9):873-80.
1992: R Lopez Lopez; Godefridus J Peters; A C van Loenen; P E Pizao; R E van Rijswijk; John Wagstaff; HERBERT PINEDO
The effect of schedule, protein binding and growth factors on the activity of suramin.
International journal of cancer. Journal international du cancer 1992;51(6):921-6.
1992: P E Pizao; B Winograd; Godefridus J Peters; A Leyva; Giuseppe Giaccone; HERBERT PINEDO
In vitro chemosensitivity testing of multilayered microcultures.
Anticancer research 1992;12(4):1319-22.
1992: Rob Pieters; D R Huismans; A H Loonen; Godefridus J Peters; Karel Hählen; Anna van der Does-van den Berg; Elisabeth R van Wering; Anjo J P Veerman
Hypoxanthine-guanine phosphoribosyl-transferase in childhood leukemia: relation with immunophenotype, in vitro drug resistance and clinical prognosis.
International journal of cancer. Journal international du cancer 1992;51(2):213-7.
1992: Rob Pieters; D R Huismans; A H Loonen; Godefridus J Peters; Karel Hählen; Anna van der Does-van den Berg; Elisabeth R van Wering; Anjo J P Veerman
Adenosine deaminase and purine nucleoside phosphorylase in childhood lymphoblastic leukemia: relation with differentiation stage, in vitro drug resistance and clinical prognosis.
Leukemia 1992;6(5):375-80.
1992: Godefridus J Peters; Cees J van Groeningen; Clasina L Van der Wilt; S Meijer; Kees Smid; E Laurensse; HERBERT PINEDO
Time course of inhibition of thymidylate synthase in patients treated with fluorouracil and leucovorin.
Seminars in oncology 1992;19(2 Suppl 3):26-35.
1992: Cees J van Groeningen; Godefridus J Peters; HERBERT PINEDO
Modulation of fluorouracil toxicity with uridine.
Seminars in oncology 1992;19(2 Suppl 3):148-54.
1992: Clasina L Van der Wilt; HERBERT PINEDO; Kees Smid; J Cloos; Paul Noordhuis; Godefridus J Peters
Effect of folinic acid on fluorouracil activity and expression of thymidylate synthase.
Seminars in oncology 1992;19(2 Suppl 3):16-25.
1992: Godefridus J Peters; I Kraal; HERBERT PINEDO
In vitro and in vivo studies on the combination of Brequinar sodium (DUP-785; NSC 368390) with 5-fluorouracil; effects of uridine.
British journal of cancer 1992;65(2):229-33.
1992: J A M Van Laar; Clasina L Van der Wilt; M Treskes; Wim J F van der Vijgh; Godefridus J Peters
Effect of WR-2721 on the toxicity and antitumor activity of the combination of carboplatin and 5-fluorouracil.
Cancer chemotherapy and pharmacology 1992;31(2):97-102.
1992: Clasina L Van der Wilt; J A M Van Laar; F Gyergyay; Kees Smid; Godefridus J Peters
Biochemical modification of the toxicity and the anti-tumour effect of 5-fluorouracil and cis-platinum by WR-2721 in mice.
European journal of cancer (Oxford, England : 1990) 1992;28A(12):2017-24.
1992: Godefridus J Peters; Clasina L Van der Wilt; F Gyergyay; J A M Van Laar; M Treskes; Wim J F van der Vijgh; HERBERT PINEDO
Protection by WR-2721 of the toxicity induced by the combination of cisplatin and 5-fluorouracil.
International journal of radiation oncology, biology, physics 1992;22(4):785-9.
1991: Godefridus J Peters; Cees J van Groeningen; E J Laurensse; HERBERT PINEDO
A comparison of 5-fluorouracil metabolism in human colorectal cancer and colon mucosa.
Cancer 1991;68(9):1903-9.
1991: Rob Pieters; L F Thompson; G J Broekema; D R Huismans; Godefridus J Peters; Steven T Pals; E Horst; Karel Hählen; Anjo J P Veerman
Expression of 5'-nucleotidase (CD73) related to other differentiation antigens in leukemias of B-cell lineage.
Blood 1991;78(2):488-92.
1991: Godefridus J Peters; Cees J van Groeningen
Clinical relevance of biochemical modulation of 5-fluorouracil.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1991;2(7):469-80.
1991: Cees J van Groeningen; Godefridus J Peters; J C Nadal; E Laurensse; HERBERT PINEDO
Clinical and pharmacologic study of orally administered uridine.
Journal of the National Cancer Institute 1991;83(6):437-41.
1991: E C Spoelstra; HERBERT PINEDO; H Dekker; Godefridus J Peters; Jan Lankelma
Measurement of in vitro cellular pharmacokinetics of 5-fluorouracil in human and rat cancer cell lines and rat hepatocytes using a flow-through system.
Cancer chemotherapy and pharmacology 1991;27(4):320-5.
1991: Y P Keepers; P E Pizao; Godefridus J Peters; J van Ark-Otte; B Winograd; HERBERT PINEDO
Comparison of the sulforhodamine B protein and tetrazolium (MTT) assays for in vitro chemosensitivity testing.
European journal of cancer (Oxford, England : 1990) 1991;27(7):897-900.
1991: Godefridus J Peters; Cees J van Groeningen; E J Laurensse; HERBERT PINEDO
Thymidylate synthase from untreated human colorectal cancer and colonic mucosa: enzyme activity and inhibition by 5-fluoro-2'-deoxy-uridine-5'-monophosphate.
European journal of cancer (Oxford, England : 1990) 1991;27(3):263-7.
1991: Boudewijn J M Braakhuis; Gerard W M Visser; I Stringer; Godefridus J Peters
In vitro antiproliferative and metabolic activity of eight novel 5-fluorinated uracil nucleosides.
European journal of cancer (Oxford, England : 1990) 1991;27(3):250-3.
1991: Veronique Ruiz van Haperen; Gijsbert Veerman; Paul Noordhuis; Jan B Vermorken; Godefridus J Peters
Concentration and time dependent growth inhibition and metabolism in vitro by 2',2'-difluoro-deoxycytidine (gemcitabine).
Advances in experimental medicine and biology 1991;309A():57-60.
1991: Godefridus J Peters; Cees J van Groeningen; Clasina L Van der Wilt; Kees Smid; S Meijer; HERBERT PINEDO
Effect of leucovorin on 5-fluorouracil induced inhibition of thymidylate synthase in patients with colon cancer.
Advances in experimental medicine and biology 1991;309A():131-4.
1991: Clasina L Van der Wilt; A Marinelli; J Cloos; Kees Smid; HERBERT PINEDO; Godefridus J Peters
Isolated liver perfusion versus hepatic artery infusion with 5-fluorouracil in a rat model; effects on thymidylate synthase.
Advances in experimental medicine and biology 1991;309A():105-8.
1990: Godefridus J Peters; Gilberto Schwartsmann; J C Nadal; E J Laurensse; Cees J van Groeningen; Wim J F van der Vijgh; HERBERT PINEDO
In vivo inhibition of the pyrimidine de novo enzyme dihydroorotic acid dehydrogenase by brequinar sodium (DUP-785; NSC 368390) in mice and patients.
Cancer research 1990;50(15):4644-9.
1990: Godefridus J Peters; HERBERT PINEDO; W Ferwerda; T W de Graaf; Willem Van Dijk
Do antimetabolites interfere with the glycosylation of cellular glycoconjugates?
European journal of cancer (Oxford, England : 1990) 1990;26(4):516-23.
1990: Boudewijn J M Braakhuis; Guus A M S van Dongen; Godefridus J Peters; M van Walsum; Gordon B Snow
Antitumor activity of brequinar sodium (Dup-785) against human head and neck squamous cell carcinoma xenografts.
Cancer letters 1990;49(2):133-7.
1990: Gerard W M Visser; G C Gorree; Godefridus J Peters; J D M Herscheid
Tissue distribution of [18F]-5-fluorouracil in mice: effects of route of administration, strain, tumour and dose.
Cancer chemotherapy and pharmacology 1990;26(3):205-9.
1990: Godefridus J Peters; J C Nadal; E J Laurensse; E de Kant; HERBERT PINEDO
Retention of in vivo antipyrimidine effects of Brequinar sodium (DUP-785; NSC 368390) in murine liver, bone marrow and colon cancer.
Biochemical pharmacology 1990;39(1):135-44.
1989: E de Kant; HERBERT PINEDO; E Laurensse; Godefridus J Peters
The relation between inhibition of cell growth and of dihydroorotic acid dehydrogenase by brequinar sodium.
Cancer letters 1989;46(2):123-7.
1989: J C Nadal; Cees J van Groeningen; HERBERT PINEDO; Godefridus J Peters
Schedule-dependency of in vivo modulation of 5-fluorouracil by leucovorin and uridine in murine colon carcinoma.
Investigational new drugs 1989;7(2-3):163-72.
1989: Godefridus J Peters; Boudewijn J M Braakhuis; E A de Bruijn; E J Laurensse; M van Walsum; HERBERT PINEDO
Enhanced therapeutic efficacy of 5'deoxy-5-fluorouridine in 5-fluorouracil resistant head and neck tumours in relation to 5-fluorouracil metabolising enzymes.
British journal of cancer 1989;59(3):327-34.
1989: Cees J van Groeningen; Godefridus J Peters; A Leyva; E Laurensse; HERBERT PINEDO
Reversal of 5-fluorouracil-induced myelosuppression by prolonged administration of high-dose uridine.
Journal of the National Cancer Institute 1989;81(2):157-62.
1989: Cees J van Groeningen; Godefridus J Peters; HERBERT PINEDO
Lack of effectiveness of combined 5-fluorouracil and leucovorin in patients with 5-fluorouracil-resistant advanced colorectal cancer.
European journal of cancer & clinical oncology 1989;25(1):45-9.
1989: Godefridus J Peters; E J Laurensse; Cees J van Groeningen; S Meijer; HERBERT PINEDO
In vitro and in vivo inhibition of thymidylate synthase of human colon cancer by 5-fluorouracil.
Advances in experimental medicine and biology 1989;253A():439-45.
1989: W R Pels Rijcken; F Telleman; Godefridus J Peters; W Ferwerda
Incorporation of 5-fluorouracil into nucleotide sugars and the effect on glycoconjugates in rat hepatoma cells and hepatocytes.
Advances in experimental medicine and biology 1989;253B():313-20.
1989: Godefridus J Peters; E Laurensse; E de Kant; J C Nadal; HERBERT PINEDO
The relationship between dihydroorotic acid dehydrogenase and in vitro and in vivo cytostatic effects of brequinar sodium (DUP-785; NSC 368390).
Advances in experimental medicine and biology 1989;253B():375-82.
1989: E J Laurensse; Boudewijn J M Braakhuis; HERBERT PINEDO; Godefridus J Peters
Fluoropyrimidine metabolism in human head and neck cancer xenografts and murine colon tumors.
Advances in experimental medicine and biology 1989;253B():327-34.
1988: Cees J van Groeningen; HERBERT PINEDO; J Heddes; R M Kok; A P de Jong; E Wattel; Godefridus J Peters; Jan Lankelma
Pharmacokinetics of 5-fluorouracil assessed with a sensitive mass spectrometric method in patients on a dose escalation schedule.
Cancer research 1988;48(23):6956-61.
1988: E J Laurensse; HERBERT PINEDO; Godefridus J Peters
A sensitive non-radioactive assay for pyrimidine nucleoside phosphorylase using reversed-phase high performance liquid chromatography.
Clinica chimica acta; international journal of clinical chemistry 1988;178(1):71-8.
1988: Gilberto Schwartsmann; Godefridus J Peters; E Laurensse; F C de Waal; A H Loonen; A Leyva; HERBERT PINEDO
DUP 785 (NSC 368390): schedule-dependency of growth-inhibitory and antipyrimidine effects.
Biochemical pharmacology 1988;37(17):3257-66.
1988: Godefridus J Peters; J van Dijk; E Laurensse; Cees J van Groeningen; Jan Lankelma; A Leyva; J C Nadal; HERBERT PINEDO
In vitro biochemical and in vivo biological studies of the uridine 'rescue' of 5-fluorouracil.
British journal of cancer 1988;57(3):259-65.
1988: J C Nadal; Cees J van Groeningen; HERBERT PINEDO; Godefridus J Peters
In vivo potentiation of 5-fluorouracil by leucovorin in murine colon carcinoma.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 1988;42(6):387-93.
1987: Godefridus J Peters; E Laurensse; A Leyva; HERBERT PINEDO
Purine nucleosides as cell-specific modulators of 5-fluorouracil metabolism and cytotoxicity.
European journal of cancer & clinical oncology 1987;23(12):1869-81.
1987: Godefridus J Peters; Cees J van Groeningen; E Laurensse; I Kraal; A Leyva; Jan Lankelma; HERBERT PINEDO
Effect of pyrimidine nucleosides on body temperatures of man and rabbit in relation to pharmacokinetic data.
Pharmaceutical research 1987;4(2):113-9.
1987: Godefridus J Peters; J Van Dijk; J C Nadal; Cees J van Groeningen; Jan Lankelma; HERBERT PINEDO
Diurnal variation in the therapeutic efficacy of 5-fluorouracil against murine colon cancer.
In vivo (Athens, Greece) 1987;1(2):113-7.
1987: Godefridus J Peters; Cees J van Groeningen; E J Laurensse; Jan Lankelma; A Leyva; HERBERT PINEDO
Uridine-induced hypothermia in mice and rats in relation to plasma and tissue levels of uridine and its metabolites.
Cancer chemotherapy and pharmacology 1987;20(2):101-8.
1986: Cees J van Groeningen; A Leyva; I Kraal; Godefridus J Peters; HERBERT PINEDO
Clinical and pharmacokinetic studies of prolonged administration of high-dose uridine intended for rescue from 5-FU toxicity.
Cancer treatment reports 1986;70(6):745-50.
1986: Godefridus J Peters; J van Dijk; Cees J van Groeningen; E J Laurensse; A Leyva; Jan Lankelma; HERBERT PINEDO
Toxicity and antitumor effect of 5-fluorouracil and its rescue by uridine.
Advances in experimental medicine and biology 1986;195 Pt B():121-8.
1985: R M Kok; A P de Jong; Cees J van Groeningen; Godefridus J Peters; Jan Lankelma
Highly sensitive determination of 5-fluorouracil in human plasma by capillary gas chromatography and negative ion chemical ionization mass spectrometry.
Journal of chromatography 1985;343(1):59-66.
1984: A Leyva; Cees J van Groeningen; I Kraal; H Gall; Godefridus J Peters; Jan Lankelma; HERBERT PINEDO
Phase I and pharmacokinetic studies of high-dose uridine intended for rescue from 5-fluorouracil toxicity.
Cancer research 1984;44(12 Pt 1):5928-33.
1984: Godefridus J Peters; I Kraal; E Laurensse; A Leyva; HERBERT PINEDO
Separation of 5-fluorouracil and uracil by ion-pair reversed-phase high-performance liquid chromatography on a column with porous polymeric packing.
Journal of chromatography 1984;307(2):464-8.