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Jan-Michael Peters

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Chemicals & Drugs

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Kristina Uzunova; Georg Petzold; Ina Poser; Brenda A Schulman; Hannelore Schutz; Holger Stark; Yusuke Toyoda; Nicholas G Brown; Billy T Dye; Anthony A Hyman; Marc A Jarvis; Rene Ladurner; Karl Mechtler; Maria Novatchkova; Jan-Michael Peters
APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complex.
Gabriela Whelan; Emanuel Kreidl; Jan-Michael Peters; Gregor Eichele
The non-redundant function of cohesin acetyltransferase Esco2: some answers and new questions.
Karin Grosstessner-Hain; Björn Hegemann; Otto Hudecz; Brian A Joughin; Norbert Kraut; Maria Novatchkova; Jan-Michael Peters; Peter Pichler; Jonathan Rameseder; Elisabeth Roitinger; Michael B Yaffe; Karl Mechtler
Quantitative phospho-proteomics to investigate the polo-like kinase 1-dependent phospho-proteome.

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All Publications

2012: Kristina Uzunova; Georg Petzold; Ina Poser; Brenda A Schulman; Hannelore Schutz; Holger Stark; Yusuke Toyoda; Nicholas G Brown; Billy T Dye; Anthony A Hyman; Marc A Jarvis; Rene Ladurner; Karl Mechtler; Maria Novatchkova; Jan-Michael Peters
APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complex.
Nature structural & molecular biology 2012;19(11):1116-23.
2012: Gabriela Whelan; Emanuel Kreidl; Jan-Michael Peters; Gregor Eichele
The non-redundant function of cohesin acetyltransferase Esco2: some answers and new questions.
Nucleus (Austin, Tex.) 2012;3(4):330-4.
2011: Karin Grosstessner-Hain; Björn Hegemann; Otto Hudecz; Brian A Joughin; Norbert Kraut; Maria Novatchkova; Jan-Michael Peters; Peter Pichler; Jonathan Rameseder; Elisabeth Roitinger; Michael B Yaffe; Karl Mechtler
Quantitative phospho-proteomics to investigate the polo-like kinase 1-dependent phospho-proteome.
Molecular & cellular proteomics : MCP 2011;10(11):M111.008540.
2011: Johann Holzmann; Johannes Fuchs; Peter Pichler; Jan-Michael Peters; Karl Mechtler
Lesson from the stoichiometry determination of the cohesin complex: a short protease mediated elution increases the recovery from cross-linked antibody-conjugated beads.
Journal of proteome research 2011;10(2):780-9.
2011: Björn Hegemann; Jean-Karim Hériché; Otto Hudecz; James Hutchins; Anthony A Hyman; Norbert Kraut; Péter Lénárt; Sihan Liu; Michael Mazanek; Karl Mechtler; Maria Novatchkova; Ina Poser; Jonathan Rameseder; Martina M Sykora; Michael B Yaffe; Jan-Michael Peters
Systematic phosphorylation analysis of human mitotic protein complexes.
Science signaling 2011;4(198):rs12.
2011: Bettina A Buschhorn; Georg Petzold; Marta Galova; Prakash Dube; Claudine Kraft; Franz Herzog; Holger Stark; Jan-Michael Peters
Substrate binding on the APC/C occurs between the coactivator Cdh1 and the processivity factor Doc1.
Nature structural & molecular biology 2011;18(1):6-13.
2010: Tomoko Nishiyama; Rene Ladurner; Julia Schmitz; Emanuel Kreidl; Alexander Schleiffer; Venugopal Bhaskara; Masashige Bando; Katsuhiko Shirahige; Anthony A Hyman; Karl Mechtler; Jan-Michael Peters
Sororin mediates sister chromatid cohesion by antagonizing Wapl.
Cell 2010;143(5):737-49.
2010: Michael H A Schmitz; Michael Held; Veerle Janssens; James Hutchins; Otto Hudecz; Elitsa Ivanova; Jozef Goris; Laura Trinkle-Mulcahy; Angus I Lamond; Ina Poser; Anthony A Hyman; Karl Mechtler; Jan-Michael Peters; Daniel W Gerlich
Live-cell imaging RNAi screen identifies PP2A-B55alpha and importin-beta1 as key mitotic exit regulators in human cells.
Nature cell biology 2010;12(9):886-93.
2010: James Hutchins; Yusuke Toyoda; Björn Hegemann; Ina Poser; Jean-Karim Hériché; Martina M Sykora; Martina Augsburg; Otto Hudecz; Bettina A Buschhorn; Jutta Bulkescher; Christian Conrad; David Comartin; Alexander Schleiffer; Mihail Sarov; Andrei Pozniakovsky; Mikolaj Michal Slabicki; Siegfried Schloissnig; Ines Steinmacher; Marit Leuschner; Andrea Ssykor; Steffen Lawo; Laurence Pelletier; Holger Stark; Kim Nasmyth; Jan Ellenberg; Richard Durbin; Frank Buchholz; Karl Mechtler; Anthony A Hyman; Jan-Michael Peters
Systematic analysis of human protein complexes identifies chromosome segregation proteins.
Science (New York, N.Y.) 2010;328(5978):593-9.
2010: Beate Neumann; Thomas Walter; Jean-Karim Hériché; Jutta Bulkescher; Holger Erfle; Christian Conrad; Phill Rogers; Ina Poser; Michael Held; Urban Liebel; Cihan Cetin; Frank Sieckmann; Gregoire Pau; Rolf Kabbe; Annelie Wünsche; Venkata Satagopam; Michael H A Schmitz; Catherine Chapuis; Daniel W Gerlich; Reinhard Schneider; Roland Eils; Wolfgang Huber; Jan-Michael Peters; Anthony A Hyman; Richard Durbin; Rainer Pepperkok; Jan Ellenberg
Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes.
Nature 2010;464(7289):721-7.
2010: Michael Mazanek; Elisabeth Roitinger; Otto Hudecz; James Hutchins; Björn Hegemann; Goran Mitulović; Thomas Taus; Christoph Stingl; Jan-Michael Peters; Karl Mechtler
A new acid mix enhances phosphopeptide enrichment on titanium- and zirconium dioxide for mapping of phosphorylation sites on protein complexes.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2010;878(5-6):515-24.
2009: erwan watrin; Jan-Michael Peters
The cohesin complex is required for the DNA damage-induced G2/M checkpoint in mammalian cells.
The EMBO journal 2009;28(17):2625-35.
2009: Steffen Lawo; Mikhail Bashkurov; Michael Mullin; Mariana Gomez Ferreria; Ralf Kittler; Bianca Habermann; Andrea Tagliaferro; Ina Poser; James Hutchins; Björn Hegemann; Deborah Pinchev; Frank Buchholz; Jan-Michael Peters; Anthony A Hyman; Anne-Claude Gingras; Laurence Pelletier
HAUS, the 8-subunit human Augmin complex, regulates centrosome and spindle integrity.
Current biology : CB 2009;19(10):816-26.
2009: Jan-Michael Peters; Venugopal Bhaskara
Cohesin acetylation: from antiestablishment to establishment.
Molecular cell 2009;34(1):1-2.
2009: Franz Herzog; Ivana Primorac; Prakash Dube; Peter Lenart; Björn Sander; Karl Mechtler; Holger Stark; Jan-Michael Peters
Structure of the anaphase-promoting complex/cyclosome interacting with a mitotic checkpoint complex.
Science (New York, N.Y.) 2009;323(5920):1477-81.
2009: Kerstin S Wendt; Jan-Michael Peters
How cohesin and CTCF cooperate in regulating gene expression.
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 2009;17(2):201-14.
2008: Jan-Michael Peters; Antonio Tedeschi; Julia Schmitz
The cohesin complex and its roles in chromosome biology.
Genes & development 2008;22(22):3089-114.
2008: Mark Petronczki; Péter Lénárt; Jan-Michael Peters
Polo on the Rise-from Mitotic Entry to Cytokinesis with Plk1.
Developmental cell 2008;14(5):646-59.
2008: Ina Poser; Mihail Sarov; James Hutchins; Jean-Karim Hériché; Yusuke Toyoda; Andrei Pozniakovsky; Daniela Weigl; Anja Nitzsche; Björn Hegemann; Alexander W Bird; Laurence Pelletier; Ralf Kittler; Sujun Hua; Ronald Naumann; Martina Augsburg; Martina M Sykora; Helmut Hofemeister; Youming Zhang; Kim Nasmyth; Kevin P White; Steffen Dietzel; Karl Mechtler; Richard Durbin; A Francis Stewart; Jan-Michael Peters; Frank Buchholz; Anthony A Hyman
BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals.
Nature methods 2008;5(5):409-15.
2008: Birgit Koch; Stephanie Kueng; Christine Ruckenbauer; Kerstin Wendt; Jan-Michael Peters
The Suv39h-HP1 histone methylation pathway is dispensable for enrichment and protection of cohesin at centromeres in mammalian cells.
Chromosoma 2008;117(2):199-210.
2008: Jan-Michael Peters
Checkpoint control: the journey continues.
Current biology : CB 2008;18(4):R170-2.
2008: Kerstin Wendt; Keisuke Yoshida; Takehiko Itoh; Masashige Bando; Birgit Koch; Erika Schirghuber; Shuichi Tsutsumi; Genta Nagae; Ko Ishihara; Tsuyoshi Mishiro; Kazuhide Yahata; Fumio Imamoto; Hiroyuki Aburatani; Mitsuyoshi Nakao; Naoko Imamoto; Kazuhiro Maeshima; Katsuhiko Shirahige; Jan-Michael Peters
Cohesin mediates transcriptional insulation by CCCTC-binding factor.
Nature 2008;451(7180):796-801.
2007: erwan watrin; Jan-Michael Peters
Molecular biology. How and when the genome sticks together.
Science (New York, N.Y.) 2007;317(5835):209-10.
2007: Mark Petronczki; Michael Glotzer; Norbert Kraut; Jan-Michael Peters
Polo-like kinase 1 triggers the initiation of cytokinesis in human cells by promoting recruitment of the RhoGEF Ect2 to the central spindle.
Developmental cell 2007;12(5):713-25.
2007: Julia Schmitz; erwan watrin; Péter Lénárt; Karl Mechtler; Jan-Michael Peters
Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase.
Current biology : CB 2007;17(7):630-6.
2007: Jesse J Lipp; Toru Hirota; Ina Poser; Jan-Michael Peters
Aurora B controls the association of condensin I but not condensin II with mitotic chromosomes.
Journal of cell science 2007;120(Pt 7):1245-55.
2007: Péter Lénárt; Mark Petronczki; Martin Steegmaier; Barbara Di Fiore; Jesse J Lipp; Matthias Hoffmann; Wolfgang J Rettig; Norbert Kraut; Jan-Michael Peters
The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1.
Current biology : CB 2007;17(4):304-15.
2007: Martin Steegmaier; Matthias Hoffmann; Anke Baum; Péter Lénárt; Mark Petronczki; Martin Krssák; Ulrich Gürtler; Pilar Garin-Chesa; Simone Lieb; Jens Quant; Matthias Grauert; Günther R Adolf; Norbert Kraut; Jan-Michael Peters; Wolfgang J Rettig
BI 2536, a potent and selective inhibitor of polo-like kinase 1, inhibits tumor growth in vivo.
Current biology : CB 2007;17(4):316-22.
2007: Michael Mazanek; Goran Mituloviae; Franz Herzog; Christoph Stingl; James Hutchins; Jan-Michael Peters; Karl Mechtler
Titanium dioxide as a chemo-affinity solid phase in offline phosphopeptide chromatography prior to HPLC-MS/MS analysis.
Nature protocols 2007;2(5):1059-69.
2007: José L Jiménez; Björn Hegemann; James Hutchins; Jan-Michael Peters; Richard Durbin
A systematic comparative and structural analysis of protein phosphorylation sites based on the mtcPTM database.
Genome biology 2007;8(5):R90.
2006: Stephanie Kueng; Björn Hegemann; Beate H Peters; Jesse J Lipp; Alexander Schleiffer; Karl Mechtler; Jan-Michael Peters
Wapl controls the dynamic association of cohesin with chromatin.
Cell 2006;127(5):955-67.
2006: Nedim Mujezinovic; Günther Raidl; James Hutchins; Jan-Michael Peters; Karl Mechtler; Frank Eisenhaber
Cleaning of raw peptide MS/MS spectra: improved protein identification following deconvolution of multiply charged peaks, isotope clusters, and removal of background noise.
Proteomics 2006;6(19):5117-31.
2006: Jan-Michael Peters
The anaphase promoting complex/cyclosome: a machine designed to destroy.
Nature reviews. Molecular cell biology 2006;7(9):644-56.
2006: erwan watrin; Jan-Michael Peters
Cohesin and DNA damage repair.
Experimental cell research 2006;312(14):2687-93.
2006: Daniel Gerlich; Birgit Koch; Florine Dupeux; Jan-Michael Peters; Jan Ellenberg
Live-cell imaging reveals a stable cohesin-chromatin interaction after but not before DNA replication.
Current biology : CB 2006;16(15):1571-8.
2006: Péter Lénárt; Jan-Michael Peters
Checkpoint activation: don't get mad too much.
Current biology : CB 2006;16(11):R412-4.
2006: Karin G Wirth; Gordana Wutz; Nobuaki R Kudo; Chantal Desdouets; Anders Zetterberg; Shahryar Taghybeeglu; Janina Jansong; Germain M Ducos; Romeo Ricci; Nicole Firnberg; Jan-Michael Peters; Kim Nasmyth
Separase: a universal trigger for sister chromatid disjunction but not chromosome cycle progression.
The Journal of cell biology 2006;172(6):847-60.
2006: Daniel Gerlich; Toru Hirota; Birgit Koch; Jan-Michael Peters; Jan Ellenberg
Condensin I stabilizes chromosomes mechanically through a dynamic interaction in live cells.
Current biology : CB 2006;16(4):333-44.
2006: Claudine Kraft; Michael Gmachl; Jan-Michael Peters
Methods to measure ubiquitin-dependent proteolysis mediated by the anaphase-promoting complex.
Methods (San Diego, Calif.) 2006;38(1):39-51.
2005: Prakash Dube; Franz Herzog; Christian Gieffers; Bjoern Sander; Dietmar Riedel; Shirley A Müller; Andreas Engel; Jan-Michael Peters; Holger Stark
Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C.
Molecular cell 2005;20(6):867-79.
2005: Toru Hirota; Jesse J Lipp; Ban-Hock Toh; Jan-Michael Peters
Histone H3 serine 10 phosphorylation by Aurora B causes HP1 dissociation from heterochromatin.
Nature 2005;438(7071):1176-80.
2005: Jan-Michael Peters
Cyclin degradation: don't mes(s) with meiosis.
Current biology : CB 2005;15(12):R461-3.
2005: Claudine Kraft; Hartmut C Vodermaier; Sebastian Maurer-Stroh; Frank Eisenhaber; Jan-Michael Peters
The WD40 propeller domain of Cdh1 functions as a destruction box receptor for APC/C substrates.
Molecular cell 2005;18(5):543-53.
2005: Barry E McGuinness; Toru Hirota; Nobuaki R Kudo; Jan-Michael Peters; Kim Nasmyth
Shugoshin prevents dissociation of cohesin from centromeres during mitosis in vertebrate cells.
PLoS biology 2005;3(3):e86.
2005: Silke Hauf; Elisabeth Roitinger; Birgit Koch; Christina M Dittrich; Karl Mechtler; Jan-Michael Peters
Dissociation of cohesin from chromosome arms and loss of arm cohesion during early mitosis depends on phosphorylation of SA2.
PLoS biology 2005;3(3):e69.
2005: Franz Herzog; Karl Mechtler; Jan-Michael Peters
Identification of cell cycle-dependent phosphorylation sites on the anaphase-promoting complex/cyclosome by mass spectrometry.
Methods in enzymology 2005;398():231-45.
2005: Franz Herzog; Jan-Michael Peters
Large-scale purification of the vertebrate anaphase-promoting complex/cyclosome.
Methods in enzymology 2005;398():175-95.
2004: Toru Hirota; Daniel Gerlich; Birgit Koch; Jan Ellenberg; Jan-Michael Peters
Distinct functions of condensin I and II in mitotic chromosome assembly.
Journal of cell science 2004;117(Pt 26):6435-45.
2004: Endre Máthé; Claudine Kraft; Régis Giet; Péter Deák; Jan-Michael Peters; David M Glover
The E2-C vihar is required for the correct spatiotemporal proteolysis of cyclin B and itself undergoes cyclical degradation.
Current biology : CB 2004;14(19):1723-33.
2004: Izabela Sumara; Juan F Giménez-Abián; Daniel Gerlich; Toru Hirota; Claudine Kraft; Consuelo de la Torre; Jan Ellenberg; Jan-Michael Peters
Roles of polo-like kinase 1 in the assembly of functional mitotic spindles.
Current biology : CB 2004;14(19):1712-22.
2004: Juan F Giménez-Abián; Izabela Sumara; Toru Hirota; Silke Hauf; Daniel Gerlich; Consuelo de la Torre; Jan Ellenberg; Jan-Michael Peters
Regulation of sister chromatid cohesion between chromosome arms.
Current biology : CB 2004;14(13):1187-93.
2004: Hartmut C Vodermaier; Jan-Michael Peters
APC activators caught by their tails?
Cell cycle (Georgetown, Tex.) 2004;3(3):265-6.
2003: Claudine Kraft; Franz Herzog; Christian Gieffers; Karl Mechtler; Anja Hagting; Jonathon Pines; Jan-Michael Peters
Mitotic regulation of the human anaphase-promoting complex by phosphorylation.
The EMBO journal 2003;22(24):6598-609.
2003: Hartmut C Vodermaier; Christian Gieffers; Sebastian Maurer-Stroh; Frank Eisenhaber; Jan-Michael Peters
TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1.
Current biology : CB 2003;13(17):1459-68.
2003: Jan-Michael Peters
Emi1 proteolysis: how SCF(beta-Trcp1) helps to activate the anaphase-promoting complex.
Molecular cell 2003;11(6):1420-1.
2003: Silke Hauf; Richard W Cole; Sabrina LaTerra; Christine Zimmer; Gisela Schnapp; Rainer Walter; Armin Heckel; Jacques van Meel; Conly L Rieder; Jan-Michael Peters
The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint.
The Journal of cell biology 2003;161(2):281-94.
2002: Irene Waizenegger; Juan F Giménez-Abián; Dominik Wernic; Jan-Michael Peters
Regulation of human separase by securin binding and autocleavage.
Current biology : CB 2002;12(16):1368-78.
2002: Anja Hagting; Nicole R den Elzen; Hartmut C Vodermaier; Irene C Waizenegger; Jan-Michael Peters; Jonathon Pines
Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1.
The Journal of cell biology 2002;157(7):1125-37.
2002: Jan-Michael Peters
The anaphase-promoting complex: proteolysis in mitosis and beyond.
Molecular cell 2002;9(5):931-43.
2002: Izabela Sumara; Elisabeth Vorlaufer; P Todd Stukenberg; Olaf Kelm; Norbert Redemann; Erich A Nigg; Jan-Michael Peters
The dissociation of cohesin from chromosomes in prophase is regulated by Polo-like kinase.
Molecular cell 2002;9(3):515-25.
2001: Kerstin Wendt; Hartmut C Vodermaier; Uwe Jacob; Christian Gieffers; Michael Gmachl; Jan-Michael Peters; Robert Huber; Peter Sondermann
Crystal structure of the APC10/DOC1 subunit of the human anaphase-promoting complex.
Nature structural biology 2001;8(9):784-8.
2001: Silke Hauf; I C Waizenegger; Jan-Michael Peters
Cohesin cleavage by separase required for anaphase and cytokinesis in human cells.
Science (New York, N.Y.) 2001;293(5533):1320-3.
2001: Christian Gieffers; Prakash Dube; J R Harris; Holger Stark; Jan-Michael Peters
Three-dimensional structure of the anaphase-promoting complex.
Molecular cell 2001;7(4):907-13.
2001: Kim Nasmyth; Jan-Michael Peters; F Uhlmann
Splitting the chromosome: cutting the ties that bind sister chromatids.
Novartis Foundation symposium 2001;237():113-33; discussion 133-8, 158-63.
2000: Izabela Sumara; Elisabeth Vorlaufer; Christian Gieffers; Beate H Peters; Jan-Michael Peters
Characterization of vertebrate cohesin complexes and their regulation in prophase.
The Journal of cell biology 2000;151(4):749-62.
2000: I C Waizenegger; Silke Hauf; A Meinke; Jan-Michael Peters
Two distinct pathways remove mammalian cohesin from chromosome arms in prophase and from centromeres in anaphase.
Cell 2000;103(3):399-410.
2000: BO Petersen; C Wagener; Federica Marinoni; ER Kramer; Marina Melixetian; eros lazzerini denchi; Christian Gieffers; C Matteucci; Jan-Michael Peters; Kristian Helin
Cell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1.
Genes & development 2000;14(18):2330-43.
2000: Michael Gmachl; Christian Gieffers; Alexandre Podtelejnikov; M Mann; Jan-Michael Peters
The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(16):8973-8.
2000: Kim Nasmyth; Jan-Michael Peters; F Uhlmann
Splitting the chromosome: cutting the ties that bind sister chromatids.
Science (New York, N.Y.) 2000;288(5470):1379-85.
2000: E R Kramer; N Scheuringer; Alexandre Podtelejnikov; M Mann; Jan-Michael Peters
Mitotic regulation of the APC activator proteins CDC20 and CDH1.
Molecular biology of the cell 2000;11(5):1555-69.
1999: Christian Gieffers; Beate H Peters; ER Kramer; C G Dotti; Jan-Michael Peters
Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(20):11317-22.
1999: R Grossberger; Christian Gieffers; Wolfgang Zachariae; Alexandre Podtelejnikov; Alexander Schleiffer; Kim Nasmyth; M Mann; Jan-Michael Peters
Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex.
The Journal of biological chemistry 1999;274(20):14500-7.
1999: Jan-Michael Peters
Subunits and substrates of the anaphase-promoting complex.
Experimental cell research 1999;248(2):339-49.
1998: Jan-Michael Peters
SCF and APC: the Yin and Yang of cell cycle regulated proteolysis.
Current opinion in cell biology 1998;10(6):759-68.
1998: ER Kramer; Christian Gieffers; G Hölzl; Markus Hengstschläger; Jan-Michael Peters
Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family.
Current biology : CB 1998;8(22):1207-10.
1998: E Vorlaufer; Jan-Michael Peters
Regulation of the cyclin B degradation system by an inhibitor of mitotic proteolysis.
Molecular biology of the cell 1998;9(7):1817-31.