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Kevin Peters

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Bhavani Kasibhatla; John Wos; Kevin G Peters
Targeting protein tyrosine phosphatase to enhance insulin action for the potential treatment of diabetes.
Artem G Evdokimov; Matthew Pokross; Richard Walter; Marlene Mekel; Brooke Cox; Chuiying Li; Randy Bechard; Frank Genbauffe; Ryan Andrews; Conrad Diven; Brian Howard; Vinit Rastogi; Jeffrey Gray; Matthew Maier; Kevin G Peters
Engineering the catalytic domain of human protein tyrosine phosphatase beta for structure-based drug discovery.
Kande K D Amarasinghe; Artem G Evdokimov; Artem G Evidokimov; Kevin Xu; Cynthia M Clark; Matthew B Maier; Anil Srivastava; Anny-Odile Colson; Gina S Gerwe; George E Stake; Brian W Howard; Matthew Pokross; Jeffrey L Gray; Kevin G Peters
Design and synthesis of potent, non-peptidic inhibitors of HPTPbeta.

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All Publications

2007: Bhavani Kasibhatla; John Wos; Kevin G Peters
Targeting protein tyrosine phosphatase to enhance insulin action for the potential treatment of diabetes.
Current opinion in investigational drugs (London, England : 2000) 2007;8(10):805-13.
2006: Artem G Evdokimov; Matthew Pokross; Richard Walter; Marlene Mekel; Brooke Cox; Chuiying Li; Randy Bechard; Frank Genbauffe; Ryan Andrews; Conrad Diven; Brian Howard; Vinit Rastogi; Jeffrey Gray; Matthew Maier; Kevin G Peters
Engineering the catalytic domain of human protein tyrosine phosphatase beta for structure-based drug discovery.
Acta crystallographica. Section D, Biological crystallography 2006;62(Pt 12):1435-45.
2006: Kande K D Amarasinghe; Artem G Evdokimov; Artem G Evidokimov; Kevin Xu; Cynthia M Clark; Matthew B Maier; Anil Srivastava; Anny-Odile Colson; Gina S Gerwe; George E Stake; Brian W Howard; Matthew Pokross; Jeffrey L Gray; Kevin G Peters
Design and synthesis of potent, non-peptidic inhibitors of HPTPbeta.
Bioorganic & medicinal chemistry letters 2006;16(16):4252-6.
2006: Sean R Klopfenstein; Artem G Evdokimov; Anny-Odile Colson; Neil Fairweather; Jeffrey J Neuman; Matthew B Maier; Jeffrey L Gray; Gina S Gerwe; George E Stake; Brian W Howard; Julie A Farmer; Matthew Pokross; Thomas R Downs; Bhavani Kasibhatla; Kevin G Peters
1,2,3,4-Tetrahydroisoquinolinyl sulfamic acids as phosphatase PTP1B inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(6):1574-8.
2006: Andrew N Carr; Brian W Howard; Hsiao T Yang; Elaine Eby-Wilkens; Paula Loos; Alex Varbanov; Angela Qu; Jeffrey P DeMuth; Michael G Davis; Alan Proia; Ronald L Terjung; Kevin G Peters
Efficacy of systemic administration of SDF-1 in a model of vascular insufficiency: support for an endothelium-dependent mechanism.
Cardiovascular research 2006;69(4):925-35.
2005: Carol L Winter; Jana S Lange; Michael G Davis; Gina S Gerwe; Thomas R Downs; Kevin G Peters; Bhavani Kasibhatla
A nonspecific phosphotyrosine phosphatase inhibitor, bis(maltolato)oxovanadium(IV), improves glucose tolerance and prevents diabetes in Zucker diabetic fatty rats.
Experimental biology and medicine (Maywood, N.J.) 2005;230(3):207-16.
2004: Richard E Waters; Ronald L Terjung; Kevin G Peters; Brian H Annex
Preclinical models of human peripheral arterial occlusive disease: implications for investigation of therapeutic agents.
Journal of applied physiology (Bethesda, Md. : 1985) 2004;97(2):773-80.
2004: Andrew N Carr; Michael G Davis; Elaine Eby-Wilkens; Brian W Howard; Bryan A Towne; Thomas E Dufresne; Kevin G Peters
Tyrosine phosphatase inhibition augments collateral blood flow in a rat model of peripheral vascular disease.
American journal of physiology. Heart and circulatory physiology 2004;287(1):H268-76.
2004: Kevin G Peters; Christopher D Kontos; P Charles Lin; Adrianne L Wong; Prema Rao; Liwen Huang; Mark Dewhirst; Sabita Sankar
Functional significance of Tie2 signaling in the adult vasculature.
Recent progress in hormone research 2004;59():51-71.
2003: Larry J Thompson; Feng Wang; Alan D Proia; Kevin G Peters; Brad Jarrold; Kenneth D Greis
Proteome analysis of the rat cornea during angiogenesis.
Proteomics 2003;3(11):2258-66.
2003: Kevin G Peters; Michael G Davis; Brian W Howard; Matthew Pokross; Vinit Rastogi; Conrad Diven; Kenneth D Greis; Elaine Eby-Wilkens; Matthew Maier; Artem G Evdokimov; Shari Soper; Frank Genbauffe
Mechanism of insulin sensitization by BMOV (bis maltolato oxo vanadium); unliganded vanadium (VO4) as the active component.
Journal of inorganic biochemistry 2003;96(2-3):321-30.
2003: Dustin E Starkey; Yasser Abdelaziez; Chong H Ahn; Jian Tu; LaShonda Anderson; Kenneth R Wehmeyer; Nicholas Izzo; Andrew N Carr; Kevin G Peters; James J Bao; H Brian Halsall; William R Heineman
Determination of endogenous extracellular signal-regulated protein kinase by microchip capillary electrophoresis.
Analytical biochemistry 2003;316(2):181-91.
2003: Dmitri V Baklanov; Kevin G Peters; Amy L Seidel; Doris Taylor; Brian H Annex
Neovascularization in intimal hyperplasia is associated with vein graft failure after coronary artery bypass surgery.
Vascular medicine (London, England) 2003;8(3):163-7.
2002: Xi-Lin Niu; Kevin G Peters; Christopher D Kontos
Deletion of the carboxyl terminus of Tie2 enhances kinase activity, signaling, and function. Evidence for an autoinhibitory mechanism.
The Journal of biological chemistry 2002;277(35):31768-73.
2002: Christopher D Kontos; Eugene H Cha; John D York; Kevin G Peters
The endothelial receptor tyrosine kinase Tie1 activates phosphatidylinositol 3-kinase and Akt to inhibit apoptosis.
Molecular and cellular biology 2002;22(6):1704-13.
2000: X Feng; K P Becker; S D Stribling; Kevin G Peters; Yusuf A Hannun
Regulation of receptor-mediated protein kinase C membrane trafficking by autophosphorylation.
The Journal of biological chemistry 2000;275(22):17024-34.
1999: Liwen Huang; Sabita Sankar; C Lin; Christopher D Kontos; Alfred D Schroff; Eugene H Cha; S M Feng; S F Li; Z Yu; Robert L Van Etten; Michael A Blanar; Kevin G Peters
HCPTPA, a protein tyrosine phosphatase that regulates vascular endothelial growth factor receptor-mediated signal transduction and biological activity.
The Journal of biological chemistry 1999;274(53):38183-8.
1999: G Chad Hughes; Brian H Annex; Bangliang Yin; Anne M Pippen; P Lin; Alan P Kypson; Kevin G Peters; James E Lowe; Kevin Paul Landolfo
Transmyocardial laser revascularization limits in vivo adenoviral-mediated gene transfer in porcine myocardium.
Cardiovascular research 1999;44(1):81-90.
1999: J T Calvert; TJ Riney; Christopher D Kontos; Eugene H Cha; V G Prieto; C R Shea; Jonathan N Berg; N C Nevin; S A Simpson; K A Pasyk; Marcy C Speer; Kevin G Peters; Douglas A Marchuk
Allelic and locus heterogeneity in inherited venous malformations.
Human molecular genetics 1999;8(7):1279-89.
1998: G Chad Hughes; James E Lowe; Alan P Kypson; James D St Louis; Anne M Pippen; Kevin G Peters; R Edward Coleman; Timothy R DeGrado; CL Donovan; Brian H Annex; Kevin Paul Landolfo
Neovascularization after transmyocardial laser revascularization in a model of chronic ischemia.
The Annals of thoracic surgery 1998;66(6):2029-36.
1998: P Lin; J A Buxton; A Acheson; Czeslaw Radziejewski; Peter C Maisonpierre; George D Yancopoulos; KM Channon; Laura P Hale; Mark Dewhirst; Samuel E George; Kevin G Peters
Antiangiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie2.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(15):8829-34.
1998: Christopher D Kontos; TP Stauffer; WP Yang; John D York; Liwen Huang; Michael A Blanar; Tobias meyer; Kevin G Peters
Tyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of phosphatidylinositol 3-kinase and Akt.
Molecular and cellular biology 1998;18(7):4131-40.
1998: M S Lyons; B Bell; D Stainier; Kevin G Peters
Isolation of the zebrafish homologues for the tie-1 and tie-2 endothelium-specific receptor tyrosine kinases.
Developmental dynamics : an official publication of the American Association of Anatomists 1998;212(1):133-40.
1998: Brian H Annex; CE Torgan; P Lin; Doris Taylor; M A Thompson; Kevin G Peters; William E Kraus
Induction and maintenance of increased VEGF protein by chronic motor nerve stimulation in skeletal muscle.
The American journal of physiology 1998;274(3 Pt 2):H860-7.
1998: Kevin G Peters; AC Coogan; D Berry; J Marks; J Dirk Iglehart; Christopher D Kontos; P Rao; Sabita Sankar; E Trogan
Expression of Tie2/Tek in breast tumour vasculature provides a new marker for evaluation of tumour angiogenesis.
British journal of cancer 1998;77(1):51-6.
1998: Alan N Tenaglia; Kevin G Peters; M H Sketch; Brian H Annex
Neovascularization in atherectomy specimens from patients with unstable angina: implications for pathogenesis of unstable angina.
American heart journal 1998;135(1):10-4.
1998: P Lin; Sabita Sankar; Siqing Shan; Mark Dewhirst; Peter J Polverini; T Q Quinn; Kevin G Peters
Inhibition of tumor growth by targeting tumor endothelium using a soluble vascular endothelial growth factor receptor.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1998;9(1):49-58.
1997: A L Wong; Zishan A Haroon; S Werner; Mark Dewhirst; Charles S Greenberg; Kevin G Peters
Tie2 expression and phosphorylation in angiogenic and quiescent adult tissues.
Circulation research 1997;81(4):567-74.
1997: KM Channon; GJ Fulton; John L Gray; Brian H Annex; GA Shetty; Michael A Blazing; Kevin G Peters; Per-Otto Hagen; Samuel E George
Efficient adenoviral gene transfer to early venous bypass grafts: comparison with native vessels.
Cardiovascular research 1997;35(3):505-13.
1997: KM Channon; GJ Fulton; MG Davies; Kevin G Peters; MD Ezekowitz; Per-Otto Hagen; Brian H Annex
Modulation of tissue factor protein expression in experimental venous bypass grafts.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(7):1313-9.
1996: S M Denning; KM Channon; Kevin G Peters; H N Oldham; Brian H Annex
Collagen subtypes III and IV expression in human vein graft atherosclerosis.
The American journal of cardiology 1996;78(6):691-4.
1995: L Huang; C W Turck; P Rao; Kevin G Peters
GRB2 and SH-PTP2: potentially important endothelial signaling molecules downstream of the TEK/TIE2 receptor tyrosine kinase.
Oncogene 1995;11(10):2097-103.
1995: Kevin G Peters; P S Rao; B S Bell; L A Kindman
Green fluorescent fusion proteins: powerful tools for monitoring protein expression in live zebrafish embryos.
Developmental biology 1995;171(1):252-7.
1995: Michael A Blanar; P H Crossley; Kevin G Peters; E Steingrímsson; Neal G Copeland; Nancy A Jenkins; Gail R Martin; W J Rutter
Meso1, a basic-helix-loop-helix protein involved in mammalian presomitic mesoderm development.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(13):5870-4.
1995: S Kim; V Lakhani; D J Costa; Ala I Sharara; J Gregory Fitz; L W Huang; Kevin G Peters; L A Kindman
Sphingolipid-gated Ca2+ release from intracellular stores of endothelial cells is mediated by a novel Ca(2+)-permeable channel.
The Journal of biological chemistry 1995;270(10):5266-9.
1995: Brian H Annex; S M Denning; KM Channon; Michael H Sketch; Richard S Stack; James Morrissey; Kevin G Peters
Differential expression of tissue factor protein in directional atherectomy specimens from patients with stable and unstable coronary syndromes.
Circulation 1995;91(3):619-22.
1994: A J Muslin; Kevin G Peters; LT Williams
Direct activation of phospholipase C-gamma by fibroblast growth factor receptor is not required for mesoderm induction in Xenopus animal caps.
Molecular and cellular biology 1994;14(5):3006-12.
1994: E Shinbrot; Kevin G Peters; LT Williams
Expression of the platelet-derived growth factor beta receptor during organogenesis and tissue differentiation in the mouse embryo.
Developmental dynamics : an official publication of the American Association of Anatomists 1994;199(3):169-75.
1994: S D Demo; A Kikuchi; Kevin G Peters; Angus M MacNicol; A J Muslin; LT Williams
Signaling molecules that mediate the actions of FGF.
Princess Takamatsu symposia 1994;24():243-9.
1994: Scott J Soifer; Kevin G Peters; J O'Keefe; Shaun R Coughlin
Disparate temporal expression of the prothrombin and thrombin receptor genes during mouse development.
The American journal of pathology 1994;144(1):60-9.
1994: R I Clyman; Kevin G Peters; Yao Qi Chen; J Escobedo; LT Williams; Harlan E Ives; E Wilson
Phospholipase C gamma activation, phosphotidylinositol hydrolysis, and calcium mobilization are not required for FGF receptor-mediated chemotaxis.
Cell adhesion and communication 1994;1(4):333-42.
1993: Kevin G Peters; C De Vries; LT Williams
Vascular endothelial growth factor receptor expression during embryogenesis and tissue repair suggests a role in endothelial differentiation and blood vessel growth.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(19):8915-9.
1993: T P Quinn; Kevin G Peters; C De Vries; N Ferrara; LT Williams
Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(16):7533-7.
1993: S Werner; W Weinberg; X Liao; Kevin G Peters; M Blessing; S H Yuspa; R L Weiner; LT Williams
Targeted expression of a dominant-negative FGF receptor mutant in the epidermis of transgenic mice reveals a role of FGF in keratinocyte organization and differentiation.
The EMBO journal 1993;12(7):2635-43.
1992: Kevin G Peters; J Marie; E Wilson; Harlan E Ives; J Escobedo; M Del Rosario; D Mirda; LT Williams
Point mutation of an FGF receptor abolishes phosphatidylinositol turnover and Ca2+ flux but not mitogenesis.
Nature 1992;358(6388):678-81.
1992: S Werner; Kevin G Peters; Michael T Longaker; F Fuller-Pace; MJ Banda; LT Williams
Large induction of keratinocyte growth factor expression in the dermis during wound healing.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(15):6896-900.
1992: Kevin G Peters; J A Escobedo; W J Fantl; LT Williams
Interactions of PDGF and FGF receptors with cytoplasmic signaling molecules.
Cold Spring Harbor symposia on quantitative biology 1992;57():63-6.
1992: Kevin G Peters; S Werner; G Chen; LT Williams
Two FGF receptor genes are differentially expressed in epithelial and mesenchymal tissues during limb formation and organogenesis in the mouse.
Development (Cambridge, England) 1992;114(1):233-43.
1992: S Werner; D S Duan; C de Vries; Kevin G Peters; D E Johnson; LT Williams
Differential splicing in the extracellular region of fibroblast growth factor receptor 1 generates receptor variants with different ligand-binding specificities.
Molecular and cellular biology 1992;12(1):82-8.