FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

René Bernards

Research Profile

Living Beings

Mouse

Chemicals & Drugs

Phenomena

RNA Interference

Physiology

Concepts & Ideas

Molecular Sequence Data

Anatomy

Disorders

Neoplasms

Co-author Network

Publications

TOP 3
Ian J Majewski; Thomas S Scerri; Marcel Winter; Melanie Bahlo; Astrid J Bosma; Annemieke Cats; Daphne de Jong; Samantha Hansford; Ingrid Hofland; Frans B L Hogervorst; David Huntsman; Jos Jonkers; Irma Kluijt; Roelof J C Kluin; René Bernards
An α-E-catenin (CTNNA1) mutation in hereditary diffuse gastric cancer.
Sidong Huang; Theo Knijnenburg; Ultan McDermott; Lorenza Mittempergher; Jacques Neefjes; Wouter Nijkamp; Anirudh Prahallad; Paul Roepman; Ramon Salazar; Andreas Schlicker; Chong Sun; Fumihiro Tanaka; Peter ten Dijke; Hidetaka Uramoto; Lodewyk F A Wessels; Mathew Garnett; Wipawadee Grernrum; Floris H Groenendijk; Michael Hölzel; Roderick L Beijersbergen; René Bernards
MED12 controls the response to multiple cancer drugs through regulation of TGF-β receptor signaling.
René Bernards
A missing link in genotype-directed cancer therapy.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of René Bernards (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Ian J Majewski; Thomas S Scerri; Marcel Winter; Melanie Bahlo; Astrid J Bosma; Annemieke Cats; Daphne de Jong; Samantha Hansford; Ingrid Hofland; Frans B L Hogervorst; David Huntsman; Jos Jonkers; Irma Kluijt; Roelof J C Kluin; René Bernards
An α-E-catenin (CTNNA1) mutation in hereditary diffuse gastric cancer.
The Journal of pathology 2013;229(4):621-9.
2012: Sidong Huang; Theo Knijnenburg; Ultan McDermott; Lorenza Mittempergher; Jacques Neefjes; Wouter Nijkamp; Anirudh Prahallad; Paul Roepman; Ramon Salazar; Andreas Schlicker; Chong Sun; Fumihiro Tanaka; Peter ten Dijke; Hidetaka Uramoto; Lodewyk F A Wessels; Mathew Garnett; Wipawadee Grernrum; Floris H Groenendijk; Michael Hölzel; Roderick L Beijersbergen; René Bernards
MED12 controls the response to multiple cancer drugs through regulation of TGF-β receptor signaling.
Cell 2012;151(5):937-50.
2012: René Bernards
A missing link in genotype-directed cancer therapy.
Cell 2012;151(3):465-8.
2012: E-J Geutjes; P K Bajpe; René Bernards
Targeting the epigenome for treatment of cancer.
Oncogene 2012;31(34):3827-44.
2012: Anirudh Prahallad; Ramon Salazar; Chong Sun; Davide Zecchin; Alberto Bardelli; Roderick L Beijersbergen; Federica Di Nicolantonio; Sidong Huang; René Bernards
Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR.
Nature 2012;483(7387):100-3.
2012: Ernst-Jan Geutjes; Paul Roepman; Sun Tian; René Bernards
Deoxycytidine kinase is overexpressed in poor outcome breast cancer and determines responsiveness to nucleoside analogs.
Breast cancer research and treatment 2012;131(3):809-18.
2011: Roderick L Beijersbergen; René Bernards
Functional subtyping of breast cancer.
Cancer discovery 2011;1(3):205-6.
2011: Ian J Majewski; René Bernards
Taming the dragon: genomic biomarkers to individualize the treatment of cancer.
Nature medicine 2011;17(3):304-12.
2011: Jeroen H Nijwening; René Bernards; Ernst-Jan Geutjes; Roderick L Beijersbergen
The histone demethylase Jarid1b (Kdm5b) is a novel component of the Rb pathway and associates with E2f-target genes in MEFs during senescence.
PloS one 2011;6(9):e25235.
2011: Mirjam T Epping; Lars A T Meijer; Oscar Krijgsman; Johannes L Bos; Pier Paolo Pandolfi; René Bernards
TSPYL5 suppresses p53 levels and function by physical interaction with USP7.
Nature cell biology 2011;13(1):102-8.
2010: René Bernards; Witold Filipowicz; David M Livingston; Enrico Mihich
Twenty-second annual Pezcoller Symposium: RNA biology and cancer.
Cancer research 2010;70(24):10034-7.
2010: Michael Hölzel; Sidong Huang; Jan Koster; Ingrid Øra; Arjan Lakeman; Huib Caron; Wouter Nijkamp; Jing Xie; Tom Callens; Shahab Asgharzadeh; Robert C Seeger; Ludwine MESSIAEN; Rogier Versteeg; René Bernards
NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome.
Cell 2010;142(2):218-29.
2010: Michiel S van der Heijden; René Bernards
Inhibition of the PI3K pathway: hope we can believe in?
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(12):3094-9.
2010: Annette M G Dirac; René Bernards
The deubiquitinating enzyme USP26 is a regulator of androgen receptor signaling.
Molecular cancer research : MCR 2010;8(6):844-54.
2010: René Bernards
It's diagnostics, stupid.
Cell 2010;141(1):13-7.
2010: Jasper Mullenders; Armida W M Fabius; Miranda M W van Dongen; Hendrik J Kuiken; Roderick L Beijersbergen; René Bernards
Interleukin-1R-associated kinase 2 is a novel modulator of the transforming growth factor beta signaling cascade.
Molecular cancer research : MCR 2010;8(4):592-603.
2010: Liesbeth C W Vredeveld; Benjamin D Rowland; Sirith Douma; René Bernards; Daniel S Peeper
Functional identification of LRF as an oncogene that bypasses RASV12-induced senescence via upregulation of CYCLIN E.
Carcinogenesis 2010;31(2):201-7.
2009: Jasper Mullenders; René Bernards
Loss-of-function genetic screens as a tool to improve the diagnosis and treatment of cancer.
Oncogene 2009;28(50):4409-20.
2009: Mirjam T Epping; Lars A T Meijer; Johannes L Bos; René Bernards
UNC45A confers resistance to histone deacetylase inhibitors and retinoic acid.
Molecular cancer research : MCR 2009;7(11):1861-70.
2009: Jasper Mullenders; Wolfgang von der Saal; Miranda M W van Dongen; Ulrike Reiff; Rogier van Willigen; Roderick L Beijersbergen; Georg Tiefenthaler; Christian Klein; René Bernards
Candidate biomarkers of response to an experimental cancer drug identified through a large-scale RNA interference genetic screen.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(18):5811-9.
2009: Sidong Huang; Jamila Laoukili; Mirjam T Epping; Jan Koster; Michael Hölzel; Bart A Westerman; Wouter Nijkamp; Akiko Hata; Shahab Asgharzadeh; Robert C Seeger; Rogier Versteeg; Roderick L Beijersbergen; René Bernards
ZNF423 is critically required for retinoic acid-induced differentiation and is a marker of neuroblastoma outcome.
Cancer cell 2009;15(4):328-40.
2009: Susan Fotheringham; Mirjam T Epping; Lindsay Stimson; Omar Khan; Victoria Wood; Francesco Pezzella; René Bernards; Nicholas B La Thangue
Genome-wide loss-of-function screen reveals an important role for the proteasome in HDAC inhibitor-induced apoptosis.
Cancer cell 2009;15(1):57-66.
2009: Jasper Mullenders; Armida W M Fabius; Mandy Madiredjo; René Bernards; Roderick L Beijersbergen
A large scale shRNA barcode screen identifies the circadian clock component ARNTL as putative regulator of the p53 tumor suppressor pathway.
PloS one 2009;4(3):e4798.
2009: Mirjam T Epping; René Bernards
Molecular basis of the anti-cancer effects of histone deacetylase inhibitors.
The international journal of biochemistry & cell biology 2009;41(1):16-20.
2009: Pieter J A Eichhorn; Menno P Creyghton; René Bernards
Protein phosphatase 2A regulatory subunits and cancer.
Biochimica et biophysica acta 2009;1795(1):1-15.
2008: René Bernards
RNAi Delivers Insights into Liver Cancer.
Cell 2008;135(5):793-5.
2008: Pieter J A Eichhorn; Magüi Gili; Maurizio Scaltriti; Violeta Serra; Marta Guzman; Wouter Nijkamp; Roderick L Beijersbergen; Vanesa Valero; Joan Seoane; René Bernards; José Baselga
Phosphatidylinositol 3-kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/phosphatidylinositol 3-kinase inhibitor NVP-BEZ235.
Cancer research 2008;68(22):9221-30.
2008: Roderik M Kortlever; Jeroen H Nijwening; René Bernards
Transforming growth factor-beta requires its target plasminogen activator inhibitor-1 for cytostatic activity.
The Journal of biological chemistry 2008;283(36):24308-13.
2008: Roderik M Kortlever; Thijn R Brummelkamp; Laurens van Meeteren; Wouter H Moolenaar; René Bernards
Suppression of the p53-dependent replicative senescence response by lysophosphatidic acid signaling.
Molecular cancer research : MCR 2008;6(9):1452-60.
2008: Mirjam T Epping; Augustinus A M Hart; Annuska M Glas; O Krijgsman; René Bernards
PRAME expression and clinical outcome of breast cancer.
British journal of cancer 2008;99(3):398-403.
2008: Katherine Stemke-Hale; Ana Maria Gonzalez-Angulo; Ana Lluch; Richard M Neve; Wen-Lin Kuo; Michael Davies; Mark Carey; Zhi Hu; Yinghui Guan; Aysegul Sahin; W Fraser Symmans; Lajos Pusztai; Laura K Nolden; Hugo Horlings; Katrien Berns; Mien-Chie Hung; Marc J van de Vijver; Vicente Valero; Joe Gray; René Bernards; Gordon B Mills; Bryan T. J. Hennessy
An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer.
Cancer research 2008;68(15):6084-91.
2007: Pieter J A Eichhorn; Menno P Creyghton; Kevin Wilhelmsen; Hans van Dam; René Bernards
A RNA interference screen identifies the protein phosphatase 2A subunit PR55gamma as a stress-sensitive inhibitor of c-SRC.
PLoS genetics 2007;3(12):e218.
2007: Mirjam T Epping; Liming Wang; Jane A Plumb; Michele Lieb; Hinrich Gronemeyer; Robert Brown; René Bernards
A functional genetic screen identifies retinoic acid signaling as a target of histone deacetylase inhibitors.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(45):17777-82.
2007: Katrien Berns; Hugo Horlings; Bryan T. J. Hennessy; Mandy Madiredjo; E Marielle Hijmans; Karin Beelen; Sabine C Linn; Ana M Gonzalez-Angulo; Katherine Stemke-Hale; Michael Hauptmann; Roderick L Beijersbergen; Gordon B Mills; Marc J van de Vijver; René Bernards
A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer.
Cancer cell 2007;12(4):395-402.
2007: Nikita Popov; Michael Wanzel; Mandy Madiredjo; Dong Zhang; Roderick L Beijersbergen; René Bernards; Roland Moll; Stephen J Elledge; Martin Eilers
The ubiquitin-specific protease USP28 is required for MYC stability.
Nature cell biology 2007;9(7):765-74.
2006: René Bernards
Exploring the uses of RNAi--gene knockdown and the Nobel Prize.
The New England journal of medicine 2006;355(23):2391-3.
2006: Roderik M Kortlever; René Bernards
Senescence, wound healing and cancer: the PAI-1 connection.
Cell cycle (Georgetown, Tex.) 2006;5(23):2697-703.
2006: Benjamin Rowland; René Bernards
Re-evaluating cell-cycle regulation by E2Fs.
Cell 2006;127(5):871-4.
2006: Mirjam T Epping; René Bernards
A causal role for the human tumor antigen preferentially expressed antigen of melanoma in cancer.
Cancer research 2006;66(22):10639-42.
2006: René Bernards; Thijn R Brummelkamp; Roderick L Beijersbergen
shRNA libraries and their use in cancer genetics.
Nature methods 2006;3(9):701-6.
2006: Sebastian M B Nijman; E Marielle Hijmans; Selma El Messaoudi; Miranda M W van Dongen; Claude Sardet; René Bernards
A functional genetic screen identifies TFE3 as a gene that confers resistance to the anti-proliferative effects of the retinoblastoma protein and transforming growth factor-beta.
The Journal of biological chemistry 2006;281(31):21582-7.
2006: Roderik M Kortlever; Paul J Higgins; René Bernards
Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence.
Nature cell biology 2006;8(8):877-84.
2006: H M Oosterkamp; Herman Neering; Sebastian M B Nijman; Annette M G Dirac; W J Mooi; René Bernards; Thijn R Brummelkamp
An evaluation of the efficacy of topical application of salicylic acid for the treatment of familial cylindromatosis.
The British journal of dermatology 2006;155(1):182-5.
2006: A Milton; K Luoto; L Ingram; Shonagh Munro; Nicola Logan; A L Graham; Thijn R Brummelkamp; E Marielle Hijmans; René Bernards; Nicholas B La Thangue
A functionally distinct member of the DP family of E2F subunits.
Oncogene 2006;25(22):3212-8.
2006: Menno P Creyghton; Giulietta Roël; Pieter J A Eichhorn; Liesbeth C Vredeveld; Olivier Destrée; René Bernards
PR130 is a modulator of the Wnt-signaling cascade that counters repression of the antagonist Naked cuticle.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(14):5397-402.
2006: Tony T Huang; Sebastian M B Nijman; Kanchan D Mirchandani; Paul J Galardy; Martin A Cohn; Wilhelm Haas; Steven P Gygi; Hidde L Ploegh; René Bernards; Alan D D'Andrea
Regulation of monoubiquitinated PCNA by DUB autocleavage.
Nature cell biology 2006;8(4):339-47.
2006: Thijn R Brummelkamp; Armida W M Fabius; Jasper Mullenders; Mandy Madiredjo; Arno Velds; Ron Kerkhoven; René Bernards; Roderick L Beijersbergen
An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors.
Nature chemical biology 2006;2(4):202-6.
2006: Annuska M Glas; Arno N Floore; Leonie J M J Delahaye; Anke T Witteveen; Rob C F Pover; Niels Bakx; Jaana S T Lahti-Domenici; Tako J Bruinsma; Marc O Warmoes; René Bernards; Lodewyk F A Wessels; Laura J van't Veer
Converting a breast cancer microarray signature into a high-throughput diagnostic test.
BMC genomics 2006;7():278.
2005: Barbara Nicke; Julie Bastien; Sophia J Khanna; Patricia H Warne; Victoria Cowling; Simon J Cook; Gordon Peters; Oona Delpuech; Almut Schulze; Katrien Berns; Jasper Mullenders; Roderick L Beijersbergen; René Bernards; Trivadi Ganesan; Julian Downward; David C Hancock
Involvement of MINK, a Ste20 family kinase, in Ras oncogene-induced growth arrest in human ovarian surface epithelial cells.
Molecular cell 2005;20(5):673-85.
2005: Sebastian M B Nijman; Mark P A Luna-Vargas; Arno Velds; Thijn R Brummelkamp; Annette M G Dirac; Titia K Sixma; René Bernards
A genomic and functional inventory of deubiquitinating enzymes.
Cell 2005;123(5):773-86.
2005: Benjamin Rowland; René Bernards; Daniel S Peeper
The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene.
Nature cell biology 2005;7(11):1074-82.
2005: Mirjam T Epping; Liming Wang; Michael J Edel; Leone Carlée; Maria Hernandez; René Bernards
The human tumor antigen PRAME is a dominant repressor of retinoic acid receptor signaling.
Cell 2005;122(6):835-47.
2005: Ingrid G M Kolfschoten; Bart van Leeuwen; Katrien Berns; Jasper Mullenders; Roderick L Beijersbergen; René Bernards; P Mathijs Voorhoeve; Reuven Agami
A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenicity.
Cell 2005;121(6):849-58.
2005: René Bernards
A functional approach to questions about life, death, and phosphorylation.
Cancer cell 2005;7(6):503-4.
2005: Hongyue Dai; Laura J van't Veer; john lamb; Yudong D He; Mao Mao; Bernard M Fine; René Bernards; Marc J van de Vijver; Paul Deutsch; Alan Sachs; Roland B Stoughton; Stephen H Friend
A cell proliferation signature is a marker of extremely poor outcome in a subpopulation of breast cancer patients.
Cancer research 2005;65(10):4059-66.
2005: Sebastian M B Nijman; Tony T Huang; Annette M G Dirac; Thijn R Brummelkamp; Ron Kerkhoven; Alan D D'Andrea; René Bernards
The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway.
Molecular cell 2005;17(3):331-9.
2005: Menno P Creyghton; Giulietta Roël; Pieter J A Eichhorn; E Marielle Hijmans; Irma Maurer; Olivier Destrée; René Bernards
PR72, a novel regulator of Wnt signaling required for Naked cuticle function.
Genes & development 2005;19(3):376-86.
2005: Annette M G Dirac; Sebastian M B Nijman; Thijn R Brummelkamp; René Bernards
Functional annotation of deubiquitinating enzymes using RNA interference.
Methods in enzymology 2005;398():554-67.
2005: Annuska M Glas; Marie José Kersten; Leonie J M J Delahaye; Anke T Witteveen; Robby E Kibbelaar; Arno Velds; Lodewyk F A Wessels; Peter Joosten; Ron Kerkhoven; René Bernards; J H J M van Krieken; Philip M Kluin; Laura J van't Veer; Daphne de Jong
Gene expression profiling in follicular lymphoma to assess clinical aggressiveness and to guide the choice of treatment.
Blood 2005;105(1):301-7.
2004: Nicola Logan; Laurent Delavaine; Anne Graham; Carmel Reilly; Jon Wilson; Thijn R Brummelkamp; E Marielle Hijmans; René Bernards; Nicholas B La Thangue
E2F-7: a distinctive E2F family member with an unusual organization of DNA-binding domains.
Oncogene 2004;23(30):5138-50.
2004: Michael J Edel; Avi Shvarts; Jan Paul Medema; René Bernards
An in vivo functional genetic screen reveals a role for the TRK-T3 oncogene in tumor progression.
Oncogene 2004;23(29):4959-65.
2004: Katrien Berns; E Marielle Hijmans; Jasper Mullenders; Thijn R Brummelkamp; Arno Velds; Mike Heimerikx; Ron Kerkhoven; Mandy Madiredjo; Wouter Nijkamp; Britta Weigelt; Reuven Agami; Wei Ge; Guy Cavet; Peter Linsley; Roderick L Beijersbergen; René Bernards
A large-scale RNAi screen in human cells identifies new components of the p53 pathway.
Nature 2004;428(6981):431-7.
2004: Blanca Scheijen; Marieke Bronk; Tiffany van der Meer; Daphne de Jong; René Bernards
High incidence of thymic epithelial tumors in E2F2 transgenic mice.
The Journal of biological chemistry 2004;279(11):10476-83.
2004: Atze T Das; Thijn R Brummelkamp; Ellen M Westerhout; Monique Vink; Mandy Madiredjo; René Bernards; Ben Berkhout
Human immunodeficiency virus type 1 escapes from RNA interference-mediated inhibition.
Journal of virology 2004;78(5):2601-5.
2004: Thijn R Brummelkamp; Katrien Berns; E Marielle Hijmans; Jasper Mullenders; A Fabius; Mike Heimerikx; Arno Velds; Ron Kerkhoven; Mandy Madiredjo; René Bernards; Roderick L Beijersbergen
Functional identification of cancer-relevant genes through large-scale RNA interference screens in mammalian cells.
Cold Spring Harbor symposia on quantitative biology 2004;69():439-45.
2003: Thijn R Brummelkamp; René Bernards
New tools for functional mammalian cancer genetics.
Nature reviews. Cancer 2003;3(10):781-9.
2003: Thijn R Brummelkamp; Sebastian M B Nijman; Annette M G Dirac; René Bernards
Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB.
Nature 2003;424(6950):797-801.
2003: Blanca Scheijen; Marieke Bronk; Tiffany van der Meer; René Bernards
Constitutive E2F1 overexpression delays endochondral bone formation by inhibiting chondrocyte differentiation.
Molecular and cellular biology 2003;23(10):3656-68.
2003: Annette M G Dirac; René Bernards
Reversal of senescence in mouse fibroblasts through lentiviral suppression of p53.
The Journal of biological chemistry 2003;278(14):11731-4.
2003: Laura J van 't Veer; Hongyue Dai; Marc J van de Vijver; Yudong D He; Augustinus A M Hart; René Bernards; Stephen H Friend
Expression profiling predicts outcome in breast cancer.
Breast cancer research : BCR 2003;5(1):57-8.
2002: Marc J van de Vijver; Yudong D He; Laura J van't Veer; Hongyue Dai; Augustinus A M Hart; Dorien W Voskuil; George J Schreiber; Johannes L Peterse; Chris Roberts; Matthew J Marton; Mark Parrish; Douwe Atsma; Anke T Witteveen; Annuska M Glas; Leonie J M J Delahaye; Tony van der Velde; Harry Bartelink; Sjoerd Rodenhuis; Emiel T Rutgers; Stephen H Friend; René Bernards
A gene-expression signature as a predictor of survival in breast cancer.
The New England journal of medicine 2002;347(25):1999-2009.
2002: Thijn R Brummelkamp; René Bernards; Reuven Agami
Stable suppression of tumorigenicity by virus-mediated RNA interference.
Cancer cell 2002;2(3):243-7.
2002: René Bernards; Robert A. Weinberg
A progression puzzle.
Nature 2002;418(6900):823.
2002: Benjamin Rowland; Serguei G Denissov; Sirith Douma; Hendrik G Stunnenberg; René Bernards; Daniel S Peeper
E2F transcriptional repressor complexes are critical downstream targets of p19(ARF)/p53-induced proliferative arrest.
Cancer cell 2002;2(1):55-65.
2002: Thijn R Brummelkamp; René Bernards; Reuven Agami
A system for stable expression of short interfering RNAs in mammalian cells.
Science (New York, N.Y.) 2002;296(5567):550-3.
2002: Reuven Agami; René Bernards
Convergence of mitogenic and DNA damage signaling in the G1 phase of the cell cycle.
Cancer letters 2002;177(2):111-8.
2002: Avi Shvarts; Thijn R Brummelkamp; Ferenc Scheeren; Eugene Koh; George Q Daley; Hergen Spits; René Bernards
A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19(ARF)-p53 signaling.
Genes & development 2002;16(6):681-6.
2002: Thijn R Brummelkamp; Roderik M Kortlever; Merel Lingbeek; Flavia Trettel; Marcy E MacDonald; Maarten van Lohuizen; René Bernards
TBX-3, the gene mutated in Ulnar-Mammary Syndrome, is a negative regulator of p19ARF and inhibits senescence.
The Journal of biological chemistry 2002;277(8):6567-72.
2002: Daniel S Peeper; Avi Shvarts; Thijn R Brummelkamp; Sirith Douma; Eugene Koh; George Q Daley; René Bernards
A functional screen identifies hDRIL1 as an oncogene that rescues RAS-induced senescence.
Nature cell biology 2002;4(2):148-53.
2002: Laura J van 't Veer; Hongyue Dai; Marc J van de Vijver; Yudong D He; Augustinus A M Hart; Mao Mao; Hans L Peterse; Karin van der Kooy; Matthew J Marton; Anke T Witteveen; George J Schreiber; Ron Kerkhoven; Chris Roberts; Peter Linsley; René Bernards; Stephen H Friend
Gene expression profiling predicts clinical outcome of breast cancer.
Nature 2002;415(6871):530-6.
2001: H Masselink; N Vastenhouw; René Bernards
B-myb rescues ras-induced premature senescence, which requires its transactivation domain.
Cancer letters 2001;171(1):87-101.
2001: Daniel S Peeper; Jan-Hermen Dannenberg; Sirith Douma; Hein te Riele; René Bernards
Escape from premature senescence is not sufficient for oncogenic transformation by Ras.
Nature cell biology 2001;3(2):198-203.
2000: Katrien Berns; C Martins; Jan-Hermen Dannenberg; Anton Berns; Hein te Riele; René Bernards
p27kip1-independent cell cycle regulation by MYC.
Oncogene 2000;19(42):4822-7.
2000: Reuven Agami; René Bernards
Distinct initiation and maintenance mechanisms cooperate to induce G1 cell cycle arrest in response to DNA damage.
Cell 2000;102(1):55-66.
2000: Katrien Berns; E Marielle Hijmans; Eugene Koh; George Q Daley; René Bernards
A genetic screen to identify genes that rescue the slow growth phenotype of c-myc null fibroblasts.
Oncogene 2000;19(29):3330-4.
2000: H Masselink; René Bernards
The adenovirus E1A binding protein BS69 is a corepressor of transcription through recruitment of N-CoR.
Oncogene 2000;19(12):1538-46.
1999: René Bernards
CDK-independent activities of D type cyclins.
Biochimica et biophysica acta 1999;1424(2-3):M17-22.
1999: Barbara Di Fiore; Giulia Guarguaglini; Antonella Palena; Ron Kerkhoven; René Bernards; Patrizia Lavia
Two E2F sites control growth-regulated and cell cycle-regulated transcription of the Htf9-a/RanBP1 gene through functionally distinct mechanisms.
The Journal of biological chemistry 1999;274(15):10339-48.
1999: P Mathijs Voorhoeve; R J Watson; P G Farlie; René Bernards; Eric W-F Lam
Rapid dephosphorylation of p107 following UV irradiation.
Oncogene 1999;18(3):679-88.
1999: P Mathijs Voorhoeve; E Marielle Hijmans; René Bernards
Functional interaction between a novel protein phosphatase 2A regulatory subunit, PR59, and the retinoblastoma-related p107 protein.
Oncogene 1999;18(2):515-24.
1998: R M Zwijsen; R S Buckle; E Marielle Hijmans; C J Loomans; René Bernards
Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1.
Genes & development 1998;12(22):3488-98.
1997: René Bernards
E2F: a nodal point in cell cycle regulation.
Biochimica et biophysica acta 1997;1333(3):M33-40.
1997: KE Allen; S de la Luna; Ron Kerkhoven; René Bernards; Nicholas B La Thangue
Distinct mechanisms of nuclear accumulation regulate the functional consequence of E2F transcription factors.
Journal of cell science 1997;110 ( Pt 22)():2819-31.
1997: Katrien Berns; E Marielle Hijmans; René Bernards
Repression of c-Myc responsive genes in cycling cells causes G1 arrest through reduction of cyclin E/CDK2 kinase activity.
Oncogene 1997;15(11):1347-56.
1997: H Tong; G Hateboer; Anastassis Perraks; René Bernards; Titia K Sixma
Crystal structure of murine/human Ubc9 provides insight into the variability of the ubiquitin-conjugating system.
The Journal of biological chemistry 1997;272(34):21381-7.
1997: Daniel S Peeper; René Bernards
Communication between the extracellular environment, cytoplasmic signalling cascades and the nuclear cell-cycle machinery.
FEBS letters 1997;410(1):11-6.
1997: Daniel S Peeper; TM Upton; MH Ladha; E Neuman; J Zalvide; René Bernards; James A DeCaprio; Mark E Ewen
Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein.
Nature 1997;386(6621):177-81.
1997: R M Zwijsen; Ellen Wientjens; Rob Klompmaker; J van der Sman; René Bernards; Rob Michalides
CDK-independent activation of estrogen receptor by cyclin D1.
Cell 1997;88(3):405-15.
1996: G Hateboer; Ron Kerkhoven; A Shvarts; René Bernards; R L Beijersbergen
Degradation of E2F by the ubiquitin-proteasome pathway: regulation by retinoblastoma family proteins and adenovirus transforming proteins.
Genes & development 1996;10(23):2960-70.
1996: G Hateboer; E Marielle Hijmans; J B Nooij; S Schlenker; Stefan Jentsch; René Bernards
mUBC9, a novel adenovirus E1A-interacting protein that complements a yeast cell cycle defect.
The Journal of biological chemistry 1996;271(42):25906-11.
1996: R L Beijersbergen; René Bernards
Cell cycle regulation by the retinoblastoma family of growth inhibitory proteins.
Biochimica et biophysica acta 1996;1287(2-3):103-20.
1996: B Smith-Sørensen; E Marielle Hijmans; R L Beijersbergen; René Bernards
Functional analysis of Burkitt's lymphoma mutant c-Myc proteins.
The Journal of biological chemistry 1996;271(10):5513-8.
1995: René Bernards
Transcriptional regulation. Flipping the Myc switch.
Current biology : CB 1995;5(8):859-61.
1995: Vicky Buck; K E Allen; T Sørensen; A Bybee; E Marielle Hijmans; P Mathijs Voorhoeve; René Bernards; Nicholas B La Thangue
Molecular and functional characterisation of E2F-5, a new member of the E2F family.
Oncogene 1995;11(1):31-8.
1995: G Hateboer; A Gennissen; Y F Ramos; Ron Kerkhoven; V Sonntag-Buck; Hendrik G Stunnenberg; René Bernards
BS69, a novel adenovirus E1A-associated protein that inhibits E1A transactivation.
The EMBO journal 1995;14(13):3159-69.
1995: R L Beijersbergen; L Carlée; Ron Kerkhoven; René Bernards
Regulation of the retinoblastoma protein-related p107 by G1 cyclin complexes.
Genes & development 1995;9(11):1340-53.
1995: E Marielle Hijmans; P Mathijs Voorhoeve; R L Beijersbergen; Laura J van 't Veer; René Bernards
E2F-5, a new E2F family member that interacts with p130 in vivo.
Molecular and cellular biology 1995;15(6):3082-9.
1995: Liang Zhu; G Enders; Jacqueline A Lees; R L Beijersbergen; René Bernards; Ed Harlow
The pRB-related protein p107 contains two growth suppression domains: independent interactions with E2F and cyclin/cdk complexes.
The EMBO journal 1995;14(9):1904-13.
1994: R L Beijersbergen; Ron Kerkhoven; Liang Zhu; L Carlée; P Mathijs Voorhoeve; René Bernards
E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo.
Genes & development 1994;8(22):2680-90.
1994: R L Beijersbergen; E Marielle Hijmans; Liang Zhu; René Bernards
Interaction of c-Myc with the pRb-related protein p107 results in inhibition of c-Myc-mediated transactivation.
The EMBO journal 1994;13(17):4080-6.
1993: G Hateboer; H Th Marc Timmers; A K Rustgi; M Billaud; Laura J van 't Veer; René Bernards
TATA-binding protein and the retinoblastoma gene product bind to overlapping epitopes on c-Myc and adenovirus E1A protein.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(18):8489-93.
1993: M Billaud; Kurt J Isselbacher; René Bernards
A dominant-negative mutant of Max that inhibits sequence-specific DNA binding by Myc proteins.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(7):2739-43.
1993: Laura J van 't Veer; R L Beijersbergen; René Bernards
N-myc suppresses major histocompatibility complex class I gene expression through down-regulation of the p50 subunit of NF-kappa B.
The EMBO journal 1993;12(1):195-200.
1992: Laura J van 't Veer; P M Lutz; Kurt J Isselbacher; René Bernards
Structure and expression of major histocompatibility complex-binding protein 2, a 275-kDa zinc finger protein that binds to an enhancer of major histocompatibility complex class I genes.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(19):8971-5.
1992: E Howard; D Marcus; J O'Brien; D Albert; René Bernards
Five DNA tumor viruses undetectable in human retinoblastomas.
Investigative ophthalmology & visual science 1992;33(5):1564-7.
1991: A K Rustgi; Nicholas J Dyson; René Bernards
Amino-terminal domains of c-myc and N-myc proteins mediate binding to the retinoblastoma gene product.
Nature 1991;352(6335):541-4.
1991: A K Rustgi; Nicholas J Dyson; D Hill; René Bernards
The c-myc oncoprotein forms a specific complex with the product of the retinoblastoma gene.
Cold Spring Harbor symposia on quantitative biology 1991;56():163-7.
1990: A K Rustgi; Laura J van 't Veer; René Bernards
Two genes encode factors with NF-kappa B- and H2TF1-like DNA-binding properties.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(22):8707-10.