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Michael Petrassi

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Chemicals & Drugs

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Protein Binding

Physiology

Protein Folding

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Publications

TOP 3
Jun Li; H Michael Petrassi; Christine Tumanut; Brian T Masick; Christopher Trussell; Jennifer L Harris
Substrate optimization for monitoring cathepsin C activity in live cells.
David C Tully; Agnès Vidal; Arnab K Chatterjee; Jennifer A Williams; Michael J Roberts; H Michael Petrassi; Glen Spraggon; Badry Bursulaya; Reynand Pacoma; Aaron Shipway; Andrew M Schumacher; Henry Danahay; Jennifer L Harris
Discovery of inhibitors of the channel-activating protease prostasin (CAP1/PRSS8) utilizing structure-based design.
H Michael Petrassi; Jennifer A Williams; Jun Li; Christine Tumanut; Jared Ek; Takashi Nakai; Brian Masick; Bradley J Backes; Jennifer L Harris
A strategy to profile prime and non-prime proteolytic substrate specificity.

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All Publications

2009: Jun Li; H Michael Petrassi; Christine Tumanut; Brian T Masick; Christopher Trussell; Jennifer L Harris
Substrate optimization for monitoring cathepsin C activity in live cells.
Bioorganic & medicinal chemistry 2009;17(3):1064-70.
2008: David C Tully; Agnès Vidal; Arnab K Chatterjee; Jennifer A Williams; Michael J Roberts; H Michael Petrassi; Glen Spraggon; Badry Bursulaya; Reynand Pacoma; Aaron Shipway; Andrew M Schumacher; Henry Danahay; Jennifer L Harris
Discovery of inhibitors of the channel-activating protease prostasin (CAP1/PRSS8) utilizing structure-based design.
Bioorganic & medicinal chemistry letters 2008;18(22):5895-9.
2005: H Michael Petrassi; Jennifer A Williams; Jun Li; Christine Tumanut; Jared Ek; Takashi Nakai; Brian Masick; Bradley J Backes; Jennifer L Harris
A strategy to profile prime and non-prime proteolytic substrate specificity.
Bioorganic & medicinal chemistry letters 2005;15(12):3162-6.
2005: H Michael Petrassi; Steven M Johnson; Hans E Purkey; Kyle P. Chiang; Traci Walkup; Xin Jiang; Evan T Powers; Jeffery W Kelly
Potent and selective structure-based dibenzofuran inhibitors of transthyretin amyloidogenesis: kinetic stabilization of the native state.
Journal of the American Chemical Society 2005;127(18):6662-71.
2005: Steven M Johnson; H Michael Petrassi; Satheesh K Palaninathan; Nilofar N Mohamedmohaideen; Hans E Purkey; Christopher Nichols; Kyle P. Chiang; Traci Walkup; James C Sacchettini; K Barry Sharpless; Jeffery W Kelly
Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
Journal of medicinal chemistry 2005;48(5):1576-87.
2002: Margaret McCammon; David Scott; Catherine A Keetch; Lesley H Greene; Hans E Purkey; H Michael Petrassi; Jeffery W Kelly; Carol V Robinson
Screening transthyretin amyloid fibril inhibitors: characterization of novel multiprotein, multiligand complexes by mass spectrometry.
Structure (London, England : 1993) 2002;10(6):851-63.
2002: Vibha B Oza; Craig Smith; Prakash Raman; Edward K Koepf; Hilal A Lashuel; H Michael Petrassi; Kyle P. Chiang; Evan T Powers; James Sachettinni; Jeffery W Kelly
Synthesis, structure, and activity of diclofenac analogues as transthyretin amyloid fibril formation inhibitors.
Journal of medicinal chemistry 2002;45(2):321-32.
2001: Xin Jiang; C S Smith; H Michael Petrassi; Per Hammarström; Joleen T White; James C Sacchettini; Jeffery W Kelly
An engineered transthyretin monomer that is nonamyloidogenic, unless it is partially denatured.
Biochemistry 2001;40(38):11442-52.
2001: H Michael Petrassi; K Barry Sharpless; Jeffery W Kelly
The copper-mediated cross-coupling of phenylboronic acids and N-hydroxyphthalimide at room temperature: synthesis of aryloxyamines.
Organic letters 2001;3(1):139-42.
2000: Thomas Klabunde; H Michael Petrassi; Vibha B Oza; Prakash Raman; Jeffery W Kelly; James C Sacchettini
Rational design of potent human transthyretin amyloid disease inhibitors.
Nature structural biology 2000;7(4):312-21.
1999: Edward K Koepf; H Michael Petrassi; G Ratnaswamy; Mary E Huff; Marius Sudol; Jeffery W Kelly
Characterization of the structure and function of W --> F WW domain variants: identification of a natively unfolded protein that folds upon ligand binding.
Biochemistry 1999;38(43):14338-51.
1999: Edward K Koepf; H Michael Petrassi; Marius Sudol; Jeffery W Kelly
WW: An isolated three-stranded antiparallel beta-sheet domain that unfolds and refolds reversibly; evidence for a structured hydrophobic cluster in urea and GdnHCl and a disordered thermal unfolded state.
Protein science : a publication of the Protein Society 1999;8(4):841-53.
1999: Vibha B Oza; H Michael Petrassi; Hans E Purkey; Jeffery W Kelly
Synthesis and evaluation of anthranilic acid-based transthyretin amyloid fibril inhibitors.
Bioorganic & medicinal chemistry letters 1999;9(1):1-6.