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John Petrini

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Publications

TOP 3
Steven S Foster; Linda K Johnson; John H J Petrini; Saurav De; Travis H Stracker
Cell cycle- and DNA repair pathway-specific effects of apoptosis on tumor suppression.
Courtney A Lovejoy; Neal F Lue; Laura Macconaill; Alan K Meeker; Nickolas Papadopoulos; John H J Petrini; Roger R Reddel; Steven Reisenweber; Joseph Rosenbluh; Patricia A Sung; Supawat Thongthip; Bert Vogelstein; Barbara A Weir; Yaara Zwang; Joanne Bruno; Titia de Lange; Saurav De; William C Hahn; Megan Hanna; Charlie Hatton; Elena Ivanova; Maria Jasin; Yuchen Jiao; Kenneth W Kinzler; Wendi Li
Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway.
Marcel Hohl; Youngho Kwon; Andrés Aguilera; Sandra Muñoz Galván; Patrick Sung; Cristina Tous; Xiaoyu Xue; John H J Petrini
The Rad50 coiled-coil domain is indispensable for Mre11 complex functions.

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All Publications

2012: Steven S Foster; Linda K Johnson; John H J Petrini; Saurav De; Travis H Stracker
Cell cycle- and DNA repair pathway-specific effects of apoptosis on tumor suppression.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(25):9953-8.
2012: Courtney A Lovejoy; Neal F Lue; Laura Macconaill; Alan K Meeker; Nickolas Papadopoulos; John H J Petrini; Roger R Reddel; Steven Reisenweber; Joseph Rosenbluh; Patricia A Sung; Supawat Thongthip; Bert Vogelstein; Barbara A Weir; Yaara Zwang; Joanne Bruno; Titia de Lange; Saurav De; William C Hahn; Megan Hanna; Charlie Hatton; Elena Ivanova; Maria Jasin; Yuchen Jiao; Kenneth W Kinzler; Wendi Li
Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway.
PLoS genetics 2012;8(7):e1002772.
2011: Marcel Hohl; Youngho Kwon; Andrés Aguilera; Sandra Muñoz Galván; Patrick Sung; Cristina Tous; Xiaoyu Xue; John H J Petrini
The Rad50 coiled-coil domain is indispensable for Mre11 complex functions.
Nature structural & molecular biology 2011;18(10):1124-31.
2011: Travis H Stracker; John H J Petrini
The MRE11 complex: starting from the ends.
Nature reviews. Molecular cell biology 2011;12(2):90-103.
2010: Razqallah Hakem; M Prakash Hande; John H J Petrini; Predrag Slijepcevic
Genome Integrity - a new open access journal.
Genome integrity 2010;1(1):1.
2009: Linda Brugmans; Nicole S Verkaik; Maurice Kunen; Ellen van Drunen; Bret R Williams; John H J Petrini; Roland Kanaar; Jeroen Essers; Dik C van Gent
NBS1 cooperates with homologous recombination to counteract chromosome breakage during replication.
DNA repair 2009;8(12):1363-70.
2009: Claire Attwooll; Müge Akpinar; John H J Petrini
The mre11 complex and the response to dysfunctional telomeres.
Molecular and cellular biology 2009;29(20):5540-51.
2009: Marco Muzi-Falconi; John H J Petrini
Checkpoint response to DNA damage.
DNA repair 2009;8(9):973.
2009: Travis H Stracker; Takehiko Usui; John H J Petrini
Taking the time to make important decisions: the checkpoint effector kinases Chk1 and Chk2 and the DNA damage response.
DNA repair 2009;8(9):1047-54.
2009: Richard B Halberg; Jesse Waggoner; Kristen Rasmussen; Alanna White; Linda Clipson; Amy J Prunuske; Jeff Bacher; Ruth Sullivan; Mary Kay Washington; Henry C Pitot; John H J Petrini; Donna G Albertson; William F Dove
Long-lived Min mice develop advanced intestinal cancers through a genetically conservative pathway.
Cancer research 2009;69(14):5768-75.
2009: Carrie A Adelman; John H J Petrini
Division of labor: DNA repair and the cell cycle specific functions of the Mre11 complex.
Cell cycle (Georgetown, Tex.) 2009;8(10):1510-4.
2009: John H J Petrini
DNA replication reaches the breaking point.
Cell 2009;137(2):211-2.
2009: Ludovic Deriano; Travis H Stracker; Annalee Baker; John H J Petrini; David B Roth
Roles for NBS1 in alternative nonhomologous end-joining of V(D)J recombination intermediates.
Molecular cell 2009;34(1):13-25.
2009: Takehiko Usui; Steven S Foster; John H J Petrini
Maintenance of the DNA-damage checkpoint requires DNA-damage-induced mediator protein oligomerization.
Molecular cell 2009;33(2):147-59.
2009: Erin R P Shull; youngsoo Lee; Hironobu Nakane; Travis H Stracker; Jingfeng Zhao; Helen R Russell; John H J Petrini; Peter J McKinnon
Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBS.
Genes & development 2009;23(2):171-80.
2009: Travis H Stracker; Bret R Williams; Ludovic Deriano; Jan-Willem F Theunissen; Carrie A Adelman; David B Roth; John H J Petrini
Artemis and nonhomologous end joining-independent influence of DNA-dependent protein kinase catalytic subunit on chromosome stability.
Molecular and cellular biology 2009;29(2):503-14.
2009: Carrie A Adelman; Saurav De; John H J Petrini
Rad50 is dispensable for the maintenance and viability of postmitotic tissues.
Molecular and cellular biology 2009;29(2):483-92.
2008: Travis H Stracker; John H J Petrini
Working together and apart: the twisted relationship of the Mre11 complex and Chk2 in apoptosis and tumor suppression.
Cell cycle (Georgetown, Tex.) 2008;7(23):3618-21.
2008: Travis H Stracker; Suzana S Couto; Carlos Cordon-Cardo; Tulio Matos; John H J Petrini
Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage.
Molecular cell 2008;31(1):21-32.
2008: Monica Morales; Yan Liu; Evagelia C Laiakis; William F Morgan; Stephen D Nimer; John H J Petrini
DNA damage signaling in hematopoietic cells: a role for Mre11 complex repair of topoisomerase lesions.
Cancer research 2008;68(7):2186-93.
2008: Carrie A Adelman; John H J Petrini
ZIP4H (TEX11) deficiency in the mouse impairs meiotic double strand break repair and the regulation of crossing over.
PLoS genetics 2008;4(3):e1000042.
2008: Hee-Sook Kim; Sangeetha Vijayakumar; Mike Reger; Jacob C Harrison; James E Haber; Clifford Weil; John H J Petrini
Functional interactions between Sae2 and the Mre11 complex.
Genetics 2008;178(2):711-23.
2007: Sanchita Krishna; Brant M Wagener; Hui Ping Liu; Yi-Chen Lo; Rosa Sterk; John H J Petrini; Jac A Nickoloff
Mre11 and Ku regulation of double-strand break repair by gene conversion and break-induced replication.
DNA repair 2007;6(6):797-808.
2007: John H J Petrini
Cell signaling. A touching response to damage.
Science (New York, N.Y.) 2007;316(5828):1138-9.
2007: Travis H Stracker; Monica Morales; Suzana S Couto; Hussein Hussein; John H J Petrini
The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex.
Nature 2007;447(7141):218-21.
2007: Takehiko Usui; John H J Petrini
The Saccharomyces cerevisiae 14-3-3 proteins Bmh1 and Bmh2 directly influence the DNA damage-dependent functions of Rad53.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(8):2797-802.
2007: Sheila Cherry; Carrie A Adelman; Jan-Willem F Theunissen; Terry J Hassold; Patricia A Hunt; John H J Petrini
The Mre11 complex influences DNA repair, synapsis, and crossing over in murine meiosis.
Current biology : CB 2007;17(4):373-8.
2006: Takehiko Usui; John H J Petrini; Monica Morales
Rad50S alleles of the Mre11 complex: questions answered and questions raised.
Experimental cell research 2006;312(14):2694-9.
2006: Katri Heikkinen; Katrin Rapakko; Sanna-Maria Karppinen; Hannele Erkko; Sakari Knuutila; Tuija Lundán; Arto Mannermaa; Anne-Lise Børresen-Dale; Ake Borg; Rosa B Barkardottir; John H J Petrini; Robert Winqvist
RAD50 and NBS1 are breast cancer susceptibility genes associated with genomic instability.
Carcinogenesis 2006;27(8):1593-9.
2006: Carrie A Adelman; John H J Petrini; Claire Attwooll
Modeling disease in the mouse: lessons from DNA damage response and cell cycle control genes.
Journal of cellular biochemistry 2006;97(3):459-73.
2006: Jan-Willem F Theunissen; John H J Petrini
Methods for studying the cellular response to DNA damage: influence of the Mre11 complex on chromosome metabolism.
Methods in enzymology 2006;409():251-84.
2005: Monica Morales; Jan-Willem F Theunissen; Carla F. Kim; Risa Kitagawa; Michael B Kastan; John H J Petrini
The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor.
Genes & development 2005;19(24):3043-54.
2005: John H J Petrini
At the end, remodeling leads to eviction.
Nature structural & molecular biology 2005;12(12):1028-9.
2005: Orna Levran; Claire Attwooll; Rashida T Henry; Kelly Milton; Kornelia Neveling; Paula Rio; Sat Dev Batish; Reinhard Kalb; Eunike Velleuer; Sandra Barral; Jurg Ott; John H J Petrini; Detlev Schindler; Helmut Hanenberg; Arleen D Auerbach
The BRCA1-interacting helicase BRIP1 is deficient in Fanconi anemia.
Nature genetics 2005;37(9):931-3.
2005: Irene Chiolo; Walter Carotenuto; Giulio Maffioletti; John H J Petrini; Marco Foiani; Giordano Liberi
Srs2 and Sgs1 DNA helicases associate with Mre11 in different subcomplexes following checkpoint activation and CDK1-mediated Srs2 phosphorylation.
Molecular and cellular biology 2005;25(13):5738-51.
2005: Jed J W Wiltzius; Marcel Hohl; James C Fleming; John H J Petrini
The Rad50 hook domain is a critical determinant of Mre11 complex functions.
Nature structural & molecular biology 2005;12(5):403-7.
2004: Robert Shroff; Ayelet Arbel-Eden; Duane R Pilch; Grzegorz Ira; William M Bonner; John H J Petrini; James E Haber; Michael Lichten
Distribution and dynamics of chromatin modification induced by a defined DNA double-strand break.
Current biology : CB 2004;14(19):1703-11.
2004: Jan Karlseder; Kristina Hoke; Olga K Mirzoeva; Christopher J Bakkenist; Michael B Kastan; John H J Petrini; Titia de Lange
The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response.
PLoS biology 2004;2(8):E240.
2004: Travis H Stracker; Jan-Willem F Theunissen; Monica Morales; John H J Petrini
The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things together.
DNA repair 2004;3(8-9):845-54.
2004: John H J Petrini; Jan-Willem F Theunissen
Double strand break metabolism and cancer susceptibility: lessons from the mre11 complex.
Cell cycle (Georgetown, Tex.) 2004;3(5):541-2.
2004: Valérie Borde; Waka Lin; Eugene Novikov; John H J Petrini; Michael Lichten; Alain Nicolas
Association of Mre11p with double-strand break sites during yeast meiosis.
Molecular cell 2004;13(3):389-401.
2003: Jan-Willem F Theunissen; Mark I Kaplan; Patricia A Hunt; Bret R Williams; David O Ferguson; Frederick W Alt; John H J Petrini
Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice.
Molecular cell 2003;12(6):1511-23.
2003: John H J Petrini; Travis H Stracker
The cellular response to DNA double-strand breaks: defining the sensors and mediators.
Trends in cell biology 2003;13(9):458-62.
2003: Olga K Mirzoeva; John H J Petrini
DNA replication-dependent nuclear dynamics of the Mre11 complex.
Molecular cancer research : MCR 2003;1(3):207-18.
2002: Carla F. Kim; Michael L Sikes; Ruth Sullivan; Leslie Erskine Huye; Michelle M Le Beau; David B Roth; Olga K Mirzoeva; Eugene M Oltz; John H J Petrini
Cancer predisposition and hematopoietic failure in Rad50(S/S) mice.
Genes & development 2002;16(17):2237-51.
2002: Karl-Peter Hopfner; Lisa Craig; Gabriel Moncalian; Robert A Zinkel; Takehiko Usui; Barbara A L Owen; Annette Karcher; Brendan Henderson; Jean-Luc Bodmer; Cynthia T McMurray; James P Carney; John H J Petrini; John A Tainer
The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair.
Nature 2002;418(6897):562-6.
2002: Bret R Williams; Olga K Mirzoeva; William F Morgan; Junyu Lin; Wesley A Dunnick; John H J Petrini
A murine model of Nijmegen breakage syndrome.
Current biology : CB 2002;12(8):648-53.
2002: Jacob Falck; John H J Petrini; Bret R Williams; Jiri Lukas; Jiri Bartek
The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways.
Nature genetics 2002;30(3):290-4.
2002: Sang Lee; Debra A Bressan; John H J Petrini; James E Haber
Complementation between N-terminal Saccharomyces cerevisiae mre11 alleles in DNA repair and telomere length maintenance.
DNA repair 2002;1(1):27-40.
2001: richard s maser; Olga K Mirzoeva; Julie Wells; HA Olivares; B R Williams; Robert A Zinkel; Peggy J Farnham; John H J Petrini
Mre11 complex and DNA replication: linkage to E2F and sites of DNA synthesis.
Molecular and cellular biology 2001;21(17):6006-16.
2001: T Usui; Hironori Ogawa; John H J Petrini
A DNA damage response pathway controlled by Tel1 and the Mre11 complex.
Molecular cell 2001;7(6):1255-66.
2001: richard s maser; Robert A Zinkel; John H J Petrini
An alternative mode of translation permits production of a variant NBS1 protein from the common Nijmegen breakage syndrome allele.
Nature genetics 2001;27(4):417-21.
2001: Olga K Mirzoeva; John H J Petrini
DNA damage-dependent nuclear dynamics of the Mre11 complex.
Molecular and cellular biology 2001;21(1):281-8.
2000: John H J Petrini
When more is better.
Nature genetics 2000;26(3):257-8.
2000: Pierre-Marie Girard; Nicolas Foray; Markus Stumm; Alastair Waugh; Enriqueta Riballo; richard s maser; W P Phillips; John H J Petrini; Colin F Arlett; Penny A Jeggo
Radiosensitivity in Nijmegen Breakage Syndrome cells is attributable to a repair defect and not cell cycle checkpoint defects.
Cancer research 2000;60(17):4881-8.
2000: X Wu; John H J Petrini; WF Heine; David Weaver; David M Livingston; J Chen
Independence of R/M/N focus formation and the presence of intact BRCA1.
Science (New York, N.Y.) 2000;289(5476):11.
2000: X D Zhu; B Küster; M Mann; John H J Petrini; Titia de Lange
Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres.
Nature genetics 2000;25(3):347-52.
2000: John H J Petrini
The Mre11 complex and ATM: collaborating to navigate S phase.
Current opinion in cell biology 2000;12(3):293-6.
2000: Dae-Sik Lim; Seong-Tae Kim; Bo Xu; richard s maser; J Lin; John H J Petrini; Michael B Kastan
ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway.
Nature 2000;404(6778):613-7.
2000: John H J Petrini
S-phase functions of the Mre11 complex.
Cold Spring Harbor symposia on quantitative biology 2000;65():405-11.
2000: Titia de Lange; John H J Petrini
A new connection at human telomeres: association of the Mre11 complex with TRF2.
Cold Spring Harbor symposia on quantitative biology 2000;65():265-73.
1999: Grant S Stewart; richard s maser; Tatjana Stankovic; Debra A Bressan; M I Kaplan; Nicolaas G J Jaspers; Anja Raams; Philip J Byrd; John H J Petrini; A Malcolm R Taylor
The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder.
Cell 1999;99(6):577-87.
1999: Debra A Bressan; B K Baxter; John H J Petrini
The Mre11-Rad50-Xrs2 protein complex facilitates homologous recombination-based double-strand break repair in Saccharomyces cerevisiae.
Molecular and cellular biology 1999;19(11):7681-7.
1999: G Luo; M S Yao; Carla F. Kim; M Mills; A R Bladl; Allan Bradley; John H J Petrini
Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(13):7376-81.
1999: John H J Petrini
The mammalian Mre11-Rad50-nbs1 protein complex: integration of functions in the cellular DNA-damage response.
American journal of human genetics 1999;64(5):1264-9.
1998: Debra A Bressan; HA Olivares; Benjamin E Nelms; John H J Petrini
Alteration of N-terminal phosphoesterase signature motifs inactivates Saccharomyces cerevisiae Mre11.
Genetics 1998;150(2):591-600.
1998: James P Carney; richard s maser; HA Olivares; Elizabeth M Davis; Michelle M Le Beau; John R Yates; L Hays; William F Morgan; John H J Petrini
The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response.
Cell 1998;93(3):477-86.
1998: Benjamin E Nelms; richard s maser; JF MacKay; M G Lagally; John H J Petrini
In situ visualization of DNA double-strand break repair in human fibroblasts.
Science (New York, N.Y.) 1998;280(5363):590-2.
1997: richard s maser; K J Monsen; Benjamin E Nelms; John H J Petrini
hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks.
Molecular and cellular biology 1997;17(10):6087-96.
1997: John H J Petrini; Debra A Bressan; M S Yao
The RAD52 epistasis group in mammalian double strand break repair.
Seminars in immunology 1997;9(3):181-8.
1996: G M Dolganov; richard s maser; A Novikov; L Tosto; S Chong; Debra A Bressan; John H J Petrini
Human Rad50 is physically associated with human Mre11: identification of a conserved multiprotein complex implicated in recombinational DNA repair.
Molecular and cellular biology 1996;16(9):4832-41.
1995: John H J Petrini; M E Walsh; C DiMare; X N Chen; julie R korenberg; David Weaver
Isolation and characterization of the human MRE11 homologue.
Genomics 1995;29(1):80-6.
1995: John H J Petrini; Y Xiao; David Weaver
DNA ligase I mediates essential functions in mammalian cells.
Molecular and cellular biology 1995;15(8):4303-8.
1994: John H J Petrini; J W Donovan; C Dimare; David Weaver
Normal V(D)J coding junction formation in DNA ligase I deficiency syndromes.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(1):176-83.
1992: Eric Vivier; N Rochet; M Ackerly; John H J Petrini; H Levine; J Daley; Paul Anderson
Signaling function of reconstituted CD16: zeta: gamma receptor complex isoforms.
International immunology 1992;4(11):1313-23.
1991: John H J Petrini; K G Huwiler; David Weaver
A wild-type DNA ligase I gene is expressed in Bloom's syndrome cells.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(17):7615-9.
1990: John H J Petrini; A M Carroll; Melvin J Bosma
T-cell receptor gene rearrangements in functional T-cell clones from severe combined immune deficient (scid) mice: reversion of the scid phenotype in individual lymphocyte progenitors.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(9):3450-3.
1990: C Schultz; John H J Petrini; J Collins; J L Claflin; K A Denis; P Gearhart; C Gritzmacher; T Manser; M Shulman; Wesley A Dunnick
Patterns and extent of isotype-specificity in the murine H chain switch DNA rearrangement.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(1):363-70.
1989: John H J Petrini; Wesley A Dunnick
Products and implied mechanism of H chain switch recombination.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(8):2932-5.
1989: A M Carroll; Richard R Hardy; John H J Petrini; Melvin J Bosma
T cell leakiness in scid mice.
Current topics in microbiology and immunology 1989;152():117-23.
1987: John H J Petrini; B Shell; M Hummel; Wesley A Dunnick
The immunoglobulin heavy chain switch: structural features of gamma 1 recombinant switch regions.
Journal of immunology (Baltimore, Md. : 1950) 1987;138(6):1940-6.
1985: P Szurek; John H J Petrini; Wesley A Dunnick
Complete nucleotide sequence of the murine gamma 3 switch region and analysis of switch recombination sites in two gamma 3-expressing hybridomas.
Journal of immunology (Baltimore, Md. : 1950) 1985;135(1):620-6.