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Andrew Petros

Research Profile

Concepts & Ideas

Phenomena

Chemicals & Drugs

Genes & Molecular Sequences

Amino Acid Sequences

Procedures

Nuclear Magnetic Resonance, Biomolecular

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Publications

TOP 3
Renaldo Mendoza; Sanjay C Panchal; Ana Pereda-Lopez; Andrew M Petros; Walter F Leise; Yaya Liu; Carol S Surowy; Rama Thimmapaya; Chaohong Sun
Cracking the molecular weight barrier: fragment screening of an aminotransferase using an NMR-based functional assay.
Chaohong Sun; Andrew M Petros; Philip J Hajduk
Fragment-based lead discovery: challenges and opportunities.
Milan Bruncko; Stephen K Tahir; Xiaohong Song; Jun Chen; Hong Ding; Jeffrey R Huth; Sha Jin; Russell A Judge; David J Madar; Chang H Park; Cheol-Min Park; Andrew M Petros; Christin Tse; Saul H Rosenberg; Steven W Elmore
N-aryl-benzimidazolones as novel small molecule HSP90 inhibitors.

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All Publications

2011: Renaldo Mendoza; Sanjay C Panchal; Ana Pereda-Lopez; Andrew M Petros; Walter F Leise; Yaya Liu; Carol S Surowy; Rama Thimmapaya; Chaohong Sun
Cracking the molecular weight barrier: fragment screening of an aminotransferase using an NMR-based functional assay.
Bioorganic & medicinal chemistry letters 2011;21(18):5248-50.
2011: Chaohong Sun; Andrew M Petros; Philip J Hajduk
Fragment-based lead discovery: challenges and opportunities.
Journal of computer-aided molecular design 2011;25(7):607-10.
2010: Milan Bruncko; Stephen K Tahir; Xiaohong Song; Jun Chen; Hong Ding; Jeffrey R Huth; Sha Jin; Russell A Judge; David J Madar; Chang H Park; Cheol-Min Park; Andrew M Petros; Christin Tse; Saul H Rosenberg; Steven W Elmore
N-aryl-benzimidazolones as novel small molecule HSP90 inhibitors.
Bioorganic & medicinal chemistry letters 2010;20(24):7503-6.
2010: Andrew M Petros; Jeffrey R Huth; Thorsten K Oost; Cheol-Min Park; Hong Ding; Xilu Wang; Haichao Zhang; Paul Nimmer; Renaldo Mendoza; Chaohong Sun; Jamey Mack; Karl Walter; Sarah Dorwin; Emily Gramling; Uri Ladror; Saul H Rosenberg; Steven W Elmore; Stephen W Fesik; Philip J Hajduk
Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR.
Bioorganic & medicinal chemistry letters 2010;20(22):6587-91.
2007: Jeffrey R Huth; Chang Park; Andrew M Petros; Aaron Kunzer; Michael D Wendt; Xilu Wang; Christopher L Lynch; Jamey C Mack; Kerry M Swift; Russell A Judge; Jun Chen; Paul L Richardson; Sha Jin; Stephen K Tahir; Edmund D Matayoshi; Sarah A Dorwin; Uri S Ladror; Jean M Severin; Karl A Walter; Diane M Bartley; Stephen W Fesik; Steven W Elmore; Philip J Hajduk
Discovery and design of novel HSP90 inhibitors using multiple fragment-based design strategies.
Chemical biology & drug design 2007;70(1):1-12.
2007: Milan Bruncko; Thorsten K Oost; Barbara A Belli; Hong Ding; Mary K Joseph; Aaron Kunzer; Darlene Martineau; William J McClellan; Michael J Mitten; Shi-Chung Ng; Paul M Nimmer; Tilman Oltersdorf; Cheol-Min Park; Andrew M Petros; Alexander R Shoemaker; Xiaohong Song; Xilu Wang; Michael D Wendt; Haichao Zhang; Stephen W Fesik; Saul H Rosenberg; Steven W Elmore
Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL.
Journal of medicinal chemistry 2007;50(4):641-62.
2006: Cheol-Min Park; Tetsuro Oie; Andrew M Petros; Haichao Zhang; Paul M Nimmer; Rodger F Henry; Steven W Elmore
Design, synthesis, and computational studies of inhibitors of Bcl-XL.
Journal of the American Chemical Society 2006;128(50):16206-12.
2006: George S Sheppard; Jieyi Wang; Megumi Kawai; Steve D Fidanze; Nwe Y BaMaung; Scott A Erickson; David M Barnes; Jason S Tedrow; Lawrence Kolaczkowski; Anil Vasudevan; David C Park; Gary T Wang; William J Sanders; Robert A Mantei; Fabio Palazzo; Lora Tucker-Garcia; Pingping Lou; Qian Zhang; Chang H Park; Ki H Kim; Andrew M Petros; Edward T Olejniczak; David G Nettesheim; Philip J Hajduk; Jack Henkin; Rick Lesniewski; Steven K Davidsen; Randy L Bell
Discovery and optimization of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2: a structural basis for the reduction of albumin binding.
Journal of medicinal chemistry 2006;49(13):3832-49.
2006: Michael D Wendt; Wang Shen; Aaron Kunzer; William J McClellan; Milan Bruncko; Thorsten K Oost; Hong Ding; Mary K Joseph; Haichao Zhang; Paul M Nimmer; Shi-Chung Ng; Alexander R Shoemaker; Andrew M Petros; Anatol Oleksijew; Kennan Marsh; Joy Bauch; Tilman Oltersdorf; Barbara A Belli; Darlene Martineau; Stephen W Fesik; Saul H Rosenberg; Steven W Elmore
Discovery and structure-activity relationship of antagonists of B-cell lymphoma 2 family proteins with chemopotentiation activity in vitro and in vivo.
Journal of medicinal chemistry 2006;49(3):1165-81.
2006: Andrew M Petros; Jurgen Dinges; David J Augeri; Steven A Baumeister; David A Betebenner; Mark G Bures; Steven W Elmore; Philip J Hajduk; Mary K Joseph; Shelley K Landis; David G Nettesheim; Saul H Rosenberg; Wang Shen; Sheela Thomas; Xilu Wang; Irini Zanze; Haichao Zhang; Stephen W Fesik
Discovery of a potent inhibitor of the antiapoptotic protein Bcl-xL from NMR and parallel synthesis.
Journal of medicinal chemistry 2006;49(2):656-63.
2005: Joy Loh; Qiulong Huang; Andrew M Petros; David G Nettesheim; Linda F van Dyk; Lucia Labrada; Samuel H Speck; Beth Levine; Edward T Olejniczak; Herbert W Virgin
A surface groove essential for viral Bcl-2 function during chronic infection in vivo.
PLoS pathogens 2005;1(1):e10.
2004: Qiulong Huang; Liping Yu; Andrew M Petros; Angelo Gunasekera; Zhihong Liu; Nan Xu; Philip J Hajduk; Jamey Mack; Stephen W Fesik; Edward T Olejniczak
Structure of the N-terminal RNA-binding domain of the SARS CoV nucleocapsid protein.
Biochemistry 2004;43(20):6059-63.
2004: Jie Qian; Martin J Voorbach; Jeffrey R Huth; Michael Coen; Haichao Zhang; Shi-Chung Ng; Kenneth M Comess; Andrew M Petros; Saul H Rosenberg; Usha Warrior; David J Burns
Discovery of novel inhibitors of Bcl-xL using multiple high-throughput screening platforms.
Analytical biochemistry 2004;328(2):131-8.
2004: Andrew M Petros; Edward T Olejniczak; Stephen W Fesik
Structural biology of the Bcl-2 family of proteins.
Biochimica et biophysica acta 2004;1644(2-3):83-94.
2004: Andrew M Petros; Angelo Gunasekera; Nan Xu; Edward T Olejniczak; Stephen W Fesik
Defining the p53 DNA-binding domain/Bcl-x(L)-binding interface using NMR.
FEBS letters 2004;559(1-3):171-4.
2004: Mary K Joseph; Larry R Solomon; Andrew M Petros; Jill Cai; Robert L Simmer; Haichao Zhang; Saul Rosenberg; Shi-Chung Ng
Divergence of Genbank and human tumor Bcl-2 sequences and implications for binding affinity to key apoptotic proteins.
Oncogene 2004;23(3):835-8.
2003: Qiulong Huang; Andrew M Petros; Herbert W Virgin; Stephen W Fesik; Edward T Olejniczak
Solution structure of the BHRF1 protein from Epstein-Barr virus, a homolog of human Bcl-2.
Journal of molecular biology 2003;332(5):1123-30.
2003: Philip J Hajduk; Renaldo Mendoza; Andrew M Petros; Jeffrey R Huth; Mark G Bures; Stephen W Fesik; Yvonne C Martin
Ligand binding to domain-3 of human serum albumin: a chemometric analysis.
Journal of computer-aided molecular design 2003;17(2-4):93-102.
2002: Qiulong Huang; Andrew M Petros; Herbert W Virgin; Stephen W Fesik; Edward T Olejniczak
Solution structure of a Bcl-2 homolog from Kaposi sarcoma virus.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(6):3428-33.
2001: Andrew M Petros; A Medek; David G Nettesheim; D H Kim; H S Yoon; Kerry M Swift; Edmund D Matayoshi; Tilman Oltersdorf; Stephen W Fesik
Solution structure of the antiapoptotic protein bcl-2.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(6):3012-7.
2000: Andrew M Petros; David G Nettesheim; Y Wang; Edward T Olejniczak; Robert P Meadows; Jamey Mack; Kerry M Swift; Edmund D Matayoshi; Haichao Zhang; Craig Thompson; Stephen W Fesik
Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies.
Protein science : a publication of the Protein Society 2000;9(12):2528-34.
1999: Paul E Wiedeman; Stephen W Fesik; Andrew M Petros; David G Nettesheim; Karl W Mollison; Benjamin C Lane; Yat Sun Or; Jay R Luly
Retention of immunosuppressant activity in an ascomycin analogue lacking a hydrogen-bonding interaction with FKBP12.
Journal of medicinal chemistry 1999;42(21):4456-61.
1999: Philip J Hajduk; Jurgen Dinges; Jeffrey M Schkeryantz; David A Janowick; M Kaminski; Michael Tufano; David J Augeri; Andrew M Petros; Vicki L Nienaber; Ping Zhong; R Hammond; Michael Coen; Bruce A Beutel; L Katz; Stephen W Fesik
Novel inhibitors of Erm methyltransferases from NMR and parallel synthesis.
Journal of medicinal chemistry 1999;42(19):3852-9.
1997: L Yu; Andrew M Petros; A Schnuchel; Ping Zhong; Jean M Severin; Karl Walter; Thomas F Holzman; Stephen W Fesik
Solution structure of an rRNA methyltransferase (ErmAM) that confers macrolide-lincosamide-streptogramin antibiotic resistance.
Nature structural biology 1997;4(6):483-9.
1996: H Liang; Andrew M Petros; Robert P Meadows; H S Yoon; David A Egan; K Walter; Thomas F Holzman; T Robins; Stephen W Fesik
Solution structure of the DNA-binding domain of a human papillomavirus E2 protein: evidence for flexible DNA-binding regions.
Biochemistry 1996;35(7):2095-103.
1995: M M Zhou; Kodi S Ravichandran; E F Olejniczak; Andrew M Petros; Robert P Meadows; M Sattler; John Harlan; Warren Wade; Steven J Burakoff; Stephen W Fesik
Structure and ligand recognition of the phosphotyrosine binding domain of Shc.
Nature 1995;378(6557):584-92.
1994: A P Hansen; Andrew M Petros; Robert P Meadows; Stephen W Fesik
Backbone dynamics of a two-domain protein: 15N relaxation studies of the amino-terminal fragment of urokinase-type plasminogen activator.
Biochemistry 1994;33(51):15418-24.
1994: H S Yoon; Philip J Hajduk; Andrew M Petros; Edward T Olejniczak; Robert P Meadows; Stephen W Fesik
Solution structure of a pleckstrin-homology domain.
Nature 1994;369(6482):672-5.
1994: A P Hansen; Andrew M Petros; Robert P Meadows; D G Nettesheim; Andrew P Mazar; Edward T Olejniczak; R X Xu; T M Pederson; Jack Henkin; Stephen W Fesik
Solution structure of the amino-terminal fragment of urokinase-type plasminogen activator.
Biochemistry 1994;33(16):4847-64.
1994: Andrew M Petros; Stephen W Fesik
Nuclear magnetic resonance methods for studying protein-ligand complexes.
Methods in enzymology 1994;239():717-39.
1993: Robert P Meadows; D G Nettesheim; R X Xu; Edward T Olejniczak; Andrew M Petros; Thomas F Holzman; Jean M Severin; E Gubbins; H Smith; Stephen W Fesik
Three-dimensional structure of the FK506 binding protein/ascomycin complex in solution by heteronuclear three- and four-dimensional NMR.
Biochemistry 1993;32(3):754-65.
1992: A P Hansen; Andrew M Petros; Andrew P Mazar; T M Pederson; A Rueter; Stephen W Fesik
A practical method for uniform isotopic labeling of recombinant proteins in mammalian cells.
Biochemistry 1992;31(51):12713-8.
1992: Andrew M Petros; Megumi Kawai; Jay R Luly; Stephen W Fesik
Conformation of two non-immunosuppressive FK506 analogs when bound to FKBP by isotope-filtered NMR.
FEBS letters 1992;308(3):309-14.
1992: Andrew M Petros; G Gemmecker; P Neri; Edward T Olejniczak; D Nettesheim; R X Xu; E G Gubbins; H Smith; Stephen W Fesik
NMR studies of an FK-506 analog, [U-13C]ascomycin, bound to FK-506-binding protein.
Journal of medicinal chemistry 1992;35(13):2467-73.
1992: R Edalji; T J Pilot-Matias; Steve D Pratt; David A Egan; Jean M Severin; E G Gubbins; Andrew M Petros; Stephen W Fesik; N S Burres; Thomas F Holzman
High-level expression of recombinant human FK-binding protein from a fusion precursor.
Journal of protein chemistry 1992;11(3):213-23.
1992: Andrew M Petros; P Neri; Stephen W Fesik
Identification of solvent-exposed regions of an FK-506 analog, ascomycin, bound to FKBP using a paramagnetic probe.
Journal of biomolecular NMR 1992;2(1):11-8.
1991: Andrew M Petros; R T Gampe; G Gemmecker; P Neri; Thomas F Holzman; R Edalji; J Hochlowski; M Jackson; J McAlpine; Jay R Luly
NMR studies of an FK-506 analogue, [U-13C]ascomycin, bound to FKBP: conformation and regions of ascomycin involved in binding.
Journal of medicinal chemistry 1991;34(9):2925-8.