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Steven Petrou

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TOP 3
Christopher A Reid; A Marie Phillips; Samuel F Berkovic; Taehwan Kim; Jun Low; Bernhard Luscher; Steven Petrou
Multiple molecular mechanisms for a single GABAA mutation in epilepsy.
Tae Hwan Kim; Steven Petrou; Julian Heng; Kay Richards; Christopher A Reid
Two lines of transgenic mice expressing cre-recombinase exhibit increased seizure susceptibility.
Tae Hwan Kim; Steven Petrou; Karin Borges; Christopher A Reid
Triheptanoin reduces seizure susceptibility in a syndrome-specific mouse model of generalized epilepsy.

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All Publications

2013: Christopher A Reid; A Marie Phillips; Samuel F Berkovic; Taehwan Kim; Jun Low; Bernhard Luscher; Steven Petrou
Multiple molecular mechanisms for a single GABAA mutation in epilepsy.
Neurology 2013;80(11):1003-8.
2013: Tae Hwan Kim; Steven Petrou; Julian Heng; Kay Richards; Christopher A Reid
Two lines of transgenic mice expressing cre-recombinase exhibit increased seizure susceptibility.
Epilepsy research 2013;104(1-2):11-6.
2013: Tae Hwan Kim; Steven Petrou; Karin Borges; Christopher A Reid
Triheptanoin reduces seizure susceptibility in a syndrome-specific mouse model of generalized epilepsy.
Epilepsy research 2013;103(1):101-5.
2013: Ernesto Vargas; Steven Petrou; Christopher A Reid
Genetic and pharmacological modulation of giant depolarizing potentials in the neonatal hippocampus associates with increased seizure susceptibility.
The Journal of physiology 2013;591(Pt 1):57-65.
2012: Todor Arsov; Samuel F Berkovic; John A Damiano; Hadassa Goldberg-Stern; Sara Kivity; Kate M Lawrence; Saul A Mullen; Steven Petrou; A Marie Phillips; Sue Rogers; Zaid Afawi; Chantal Trager; Ingrid E Scheffer
Glucose transporter 1 deficiency in the idiopathic generalized epilepsies.
Annals of neurology 2012;72(5):807-15.
2012: Megan Oliva; Samuel F Berkovic; Steven Petrou
Sodium channels and the neurobiology of epilepsy.
Epilepsia 2012;53(11):1849-59.
2012: Elena V Gazina; Steven Petrou
Viral targets of acylguanidines.
Drug discovery today 2012;17(17-18):1039-43.
2012: Ben J Gu; Steven Petrou; Valentina A Valova; Ashley I Bush; James A Duce; Bruce Wong; James S Wiley
P2X7 receptor-mediated scavenger activity of mononuclear phagocytes toward non-opsonized particles and apoptotic cells is inhibited by serum glycoproteins but remains active in cerebrospinal fluid.
The Journal of biological chemistry 2012;287(21):17318-30.
2012: Mark Denham; Mirella Dottori; Bryan Leaw; Clare L Parish; Steven Petrou; Christopher A Reid; Jordan Wright; Lachlan H Thompson
Neurons derived from human embryonic stem cells extend long-distance axonal projections through growth along host white matter tracts after intra-cerebral transplantation.
Frontiers in cellular neuroscience 2012;6():11.
2012: Christopher A Reid; A Marie Phillips; Steven Petrou
HCN channelopathies: pathophysiology in genetic epilepsy and therapeutic implications.
British journal of pharmacology 2012;165(1):49-56.
2011: Elena V Gazina; David N Harrison; Jessica K Holien; Michael W Parker; Jamie J Arnold; Craig E Cameron; Brett A Cromer; Eric D Smidansky; Steven Petrou
Amiloride is a competitive inhibitor of coxsackievirus B3 RNA polymerase.
Journal of virology 2011;85(19):10364-74.
2011: Ben J Gu; Steven Petrou; Bernadette M Saunders; James S Wiley
P2X(7) is a scavenger receptor for apoptotic cells in the absence of its ligand, extracellular ATP.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(5):2365-75.
2011: Elisa L Hill; Suzanne Hosie; Rachel S Mulligan; Kay L Richards; Philip J Davies; Celine M Dubé; Tallie Z Baram; Christopher A Reid; Mathew V Jones; Steven Petrou
Temperature elevation increases GABA(A) -mediated cortical inhibition in a mouse model of genetic epilepsy.
Epilepsia 2011;52(1):179-84.
2011: Christopher A Reid; Tae Hwan Kim; Samuel F Berkovic; Steven Petrou
Low blood glucose precipitates spike-and-wave activity in genetically predisposed animals.
Epilepsia 2011;52(1):115-20.
2010: Christopher A Reid; Graeme D Jackson; Samuel F Berkovic; Steven Petrou
New therapeutic opportunities in epilepsy: a genetic perspective.
Pharmacology & therapeutics 2010;128(2):274-80.
2010: Verena C Wimmer; Christopher A Reid; Suzanne Mitchell; Kay L Richards; Byron B Scaf; Bryan T Leaw; Elisa L Hill; Michel Royeck; Marie-Therese Horstmann; Brett A Cromer; Philip J Davies; Ruwei Xu; Holger Lerche; Samuel F Berkovic; Heinz Beck; Steven Petrou
Axon initial segment dysfunction in a mouse model of genetic epilepsy with febrile seizures plus.
The Journal of clinical investigation 2010;120(8):2661-71.
2010: Verena C Wimmer; Christopher A Reid; Eva Y-W So; Samuel F Berkovic; Steven Petrou
Axon initial segment dysfunction in epilepsy.
The Journal of physiology 2010;588(Pt 11):1829-40.
2010: Leanne M Dibbens; Christopher A Reid; Bree L Hodgson; Evan A Thomas; Alison M Phillips; Elena Gazina; Brett A Cromer; Alison L Clarke; Tallie Z Baram; Ingrid E Scheffer; Samuel F Berkovic; Steven Petrou
Augmented currents of an HCN2 variant in patients with febrile seizure syndromes.
Annals of neurology 2010;67(4):542-6.
2010: Elena V Gazina; K L Richards; M B C Mokhtar; Evan A Thomas; C A Reid; Steven Petrou
Differential expression of exon 5 splice variants of sodium channel alpha subunit mRNAs in the developing mouse brain.
Neuroscience 2010;166(1):195-200.
2010: Michael K Bird; Christopher A Reid; Feng Chen; Heneu O Tan; Steven Petrou; Andrew J Lawrence
Cocaine-mediated synaptic potentiation is absent in VTA neurons from mGlu5-deficient mice.
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2010;13(2):133-41.
2010: Marcel P Goldschen-Ohm; David A Wagner; Steven Petrou; Mathew V Jones
An epilepsy-related region in the GABA(A) receptor mediates long-distance effects on GABA and benzodiazepine binding sites.
Molecular pharmacology 2010;77(1):35-45.
2009: Evan A Thomas; Christopher A Reid; Samuel F Berkovic; Steven Petrou
Prediction by modeling that epilepsy may be caused by very small functional changes in ion channels.
Archives of neurology 2009;66(10):1225-32.
2009: Evan A Thomas; Roger J Hawkins; Kay L Richards; Ruwei Xu; Elena V Gazina; Steven Petrou
Heat opens axon initial segment sodium channels: a febrile seizure mechanism?
Annals of neurology 2009;66(2):219-26.
2009: Christopher A Reid; Samuel F Berkovic; Steven Petrou
Mechanisms of human inherited epilepsies.
Progress in neurobiology 2009;87(1):41-57.
2008: Cindy Chiu; Christopher A Reid; Heneu O Tan; Philip J Davies; Frank N Single; Irene Koukoulas; Samuel F Berkovic; Seong-Seng Tan; Rolf Sprengel; Mathew V Jones; Steven Petrou
Developmental impact of a familial GABAA receptor epilepsy mutation.
Annals of neurology 2008;64(3):284-93.
2008: Heneu O Tan; Christopher A Reid; Cindy Chiu; Mathew V Jones; Steven Petrou
Increased thalamic inhibition in the absence seizure prone DBA/2J mouse.
Epilepsia 2008;49(5):921-5.
2008: Joanna Cobb; Cara Büsst; Steven Petrou; Stephen B Harrap; Justine Ellis
Searching for functional genetic variants in non-coding DNA.
Clinical and experimental pharmacology & physiology 2008;35(4):372-5.
2008: David N Harrison; Elena V Gazina; Damian F J Purcell; David Anderson; Steven Petrou
Amiloride derivatives inhibit coxsackievirus B3 RNA replication.
Journal of virology 2008;82(3):1465-73.
2007: Jenny M Gunnersen; Mary H Kim; Stephanie J Fuller; Melanie de Silva; Joanne M Britto; Vicki E Hammond; Philip J Davies; Steven Petrou; E S Louise Faber; Pankaj Sah; Seong-Seng Tan
Sez-6 proteins affect dendritic arborization patterns and excitability of cortical pyramidal neurons.
Neuron 2007;56(4):621-39.
2007: Heneu O Tan; Christopher A Reid; Frank N Single; Philip J Davies; Cindy Chiu; Susan Murphy; Alison L Clarke; Leanne M Dibbens; Heinz E Krestel; John C Mulley; Mathew V Jones; Peter H Seeburg; Bert Sakmann; Samuel F Berkovic; Rolf Sprengel; Steven Petrou
Reduced cortical inhibition in a mouse model of familial childhood absence epilepsy.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(44):17536-41.
2007: Yaroslav Teper; Douglas Whyte; Elizabeth Cahir; Henry A Lester; Sharon R Grady; Michael J Marks; Bruce N Cohen; Carlos Fonck; Tristan McClure-Begley; J Michael McIntosh; Cesar Labarca; Andrew Lawrence; Feng Chen; Ilse Gantois; Philip J Davies; Steven Petrou; Mark Murphy; John Waddington; Malcolm K Horne; Samuel F Berkovic; John Drago
Nicotine-induced dystonic arousal complex in a mouse line harboring a human autosomal-dominant nocturnal frontal lobe epilepsy mutation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(38):10128-42.
2007: Ruwei Xu; Evan A Thomas; Elena V Gazina; K L Richards; M Quick; Robyn H Wallace; Louise A Harkin; Sarah E Heron; Samuel F Berkovic; Ingrid E Scheffer; John C Mulley; Steven Petrou
Generalized epilepsy with febrile seizures plus-associated sodium channel beta1 subunit mutations severely reduce beta subunit-mediated modulation of sodium channel function.
Neuroscience 2007;148(1):164-74.
2007: Evan A Thomas; Ruwei Xu; Steven Petrou
Computational analysis of the R85C and R85H epilepsy mutations in Na+ channel beta1 subunits.
Neuroscience 2007;147(4):1034-46.
2007: Ruwei Xu; Evan A Thomas; Misty Jenkins; Elena V Gazina; Cindy Chiu; Sarah E Heron; John C Mulley; Ingrid E Scheffer; Samuel F Berkovic; Steven Petrou
A childhood epilepsy mutation reveals a role for developmentally regulated splicing of a sodium channel.
Molecular and cellular neurosciences 2007;35(2):292-301.
2007: Ingrid E Scheffer; Louise A Harkin; Bronwyn E Grinton; Leanne M Dibbens; Samantha J Turner; Marta A Zielinski; Ruwei Xu; Graeme Jackson; Judith Adams; Mary Connellan; Steven Petrou; R Mark Wellard; Regula S Briellmann; Robyn H Wallace; John C Mulley; Samuel F Berkovic
Temporal lobe epilepsy and GEFS+ phenotypes associated with SCN1B mutations.
Brain : a journal of neurology 2007;130(Pt 1):100-9.
2006: Lige Liu; Thomas Zheng; Margaret J Morris; Charlott Wallengren; Alison L Clarke; Christopher A Reid; Steven Petrou; Terence J O'Brien
The mechanism of carbamazepine aggravation of absence seizures.
The Journal of pharmacology and experimental therapeutics 2006;319(2):790-8.
2006: Samuel F Berkovic; Steven Petrou
Febrile seizures: traffic slows in the heat.
Trends in molecular medicine 2006;12(8):343-4.
2006: Samuel F Berkovic; John C Mulley; Ingrid E Scheffer; Steven Petrou
Human epilepsies: interaction of genetic and acquired factors.
Trends in neurosciences 2006;29(7):391-7.
2006: Anne N Shemon; Ronald Sluyter; Suran L Fernando; Alison L Clarke; Lan-Phuong Dao-Ung; Kristen K Skarratt; Bernadette M Saunders; Khai See Tan; Ben J Gu; Stephen J Fuller; Warwick J Britton; Steven Petrou; James S Wiley
A Thr357 to Ser polymorphism in homozygous and compound heterozygous subjects causes absent or reduced P2X7 function and impairs ATP-induced mycobacterial killing by macrophages.
The Journal of biological chemistry 2006;281(4):2079-86.
2005: Elena V Gazina; David N Harrison; Meryem Jefferies; Heneu Tan; David Williams; David Anderson; Steven Petrou
Ion transport blockers inhibit human rhinovirus 2 release.
Antiviral research 2005;67(2):98-106.
2005: John C Mulley; Ingrid E Scheffer; Steven Petrou; Leanne M Dibbens; Samuel F Berkovic; Louise A Harkin
SCN1A mutations and epilepsy.
Human mutation 2005;25(6):535-42.
2004: Ben J Gu; Ronald Sluyter; Kristen K Skarratt; Anne N Shemon; Lan-Phuong Dao-Ung; Stephen J Fuller; Julian A Barden; Alison L Clarke; Steven Petrou; James S Wiley
An Arg307 to Gln polymorphism within the ATP-binding site causes loss of function of the human P2X7 receptor.
The Journal of biological chemistry 2004;279(30):31287-95.
2004: Leanne M Dibbens; Hua-Jun Feng; Michaella C Richards; Louise A Harkin; Bree L Hodgson; Darren Scott; Misty Jenkins; Steven Petrou; Grant R Sutherland; Ingrid E Scheffer; Samuel F Berkovic; Robert L Macdonald; John C Mulley
GABRD encoding a protein for extra- or peri-synaptic GABAA receptors is a susceptibility locus for generalized epilepsies.
Human molecular genetics 2004;13(13):1315-9.
2003: Suzanne Rogers; Jenalle D Chandler; Alison L Clarke; Steven Petrou; James D Best
Glucose transporter GLUT12-functional characterization in Xenopus laevis oocytes.
Biochemical and biophysical research communications 2003;308(3):422-6.
2003: James S Wiley; Lan-Phuong Dao-Ung; Changping Li; Anne N Shemon; Ben J Gu; Megan L Smart; Stephen J Fuller; Julian A Barden; Steven Petrou; Ronald Sluyter
An Ile-568 to Asn polymorphism prevents normal trafficking and function of the human P2X7 receptor.
The Journal of biological chemistry 2003;278(19):17108-13.
2003: John C Mulley; Ingrid E Scheffer; Steven Petrou; Samuel F Berkovic
Channelopathies as a genetic cause of epilepsy.
Current opinion in neurology 2003;16(2):171-6.
2003: Megan L Smart; Ben Gu; Rekha G Panchal; James Wiley; Brett Cromer; David A Williams; Steven Petrou
P2X7 receptor cell surface expression and cytolytic pore formation are regulated by a distal C-terminal region.
The Journal of biological chemistry 2003;278(10):8853-60.
2003: Alison L Clarke; Steven Petrou; John V Walsh; Joshua J Singer
Site of action of fatty acids and other charged lipids on BKCa channels from arterial smooth muscle cells.
American journal of physiology. Cell physiology 2003;284(3):C607-19.
2002: David N Bowser; David A Wagner; Cynthia Czajkowski; Brett A Cromer; Michael W Parker; Robyn H Wallace; Louise A Harkin; John C Mulley; Carla Marini; Samuel F Berkovic; David A Williams; Mathew V Jones; Steven Petrou
Altered kinetics and benzodiazepine sensitivity of a GABAA receptor subunit mutation [gamma 2(R43Q)] found in human epilepsy.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(23):15170-5.
2002: Alison L Clarke; Steven Petrou; John V Walsh; Joshua J Singer
Modulation of BK(Ca) channel activity by fatty acids: structural requirements and mechanism of action.
American journal of physiology. Cell physiology 2002;283(5):C1441-53.
2002: Gavin K Doolan; Rekha G Panchal; Eva L Fonnes; Alison L Clarke; David A Williams; Steven Petrou
Fatty acid augmentation of the cardiac slowly activating delayed rectifier current (IKs) is conferred by hminK.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(12):1662-4.
2002: Megan L Smart; Rekha G Panchal; David N Bowser; David A Williams; Steven Petrou
Pore formation is not associated with macroscopic redistribution of P2X7 receptors.
American journal of physiology. Cell physiology 2002;283(1):C77-84.
2002: David N Bowser; Steven Petrou; Rekha G Panchal; Megan L Smart; David A Williams
Release of mitochondrial Ca2+ via the permeability transition activates endoplasmic reticulum Ca2+ uptake.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(9):1105-7.
2002: Rebecca Worthington; Megan L Smart; Ben J Gu; David A Williams; Steven Petrou; James S Wiley; Julian A Barden
Point mutations confer loss of ATP-induced human P2X(7) receptor function.
FEBS letters 2002;512(1-3):43-6.
2002: Louise A Harkin; David N Bowser; Leanne M Dibbens; Rita Singh; Fiona L Phillips; Robyn H Wallace; Michaella C Richards; David A Williams; John C Mulley; Samuel F Berkovic; Ingrid E Scheffer; Steven Petrou
Truncation of the GABA(A)-receptor gamma2 subunit in a family with generalized epilepsy with febrile seizures plus.
American journal of human genetics 2002;70(2):530-6.
2001: Rekha G Panchal; David A Williams; Peter D Kitchener; AM Reilly; J Khan; David N Bowser; Steven Petrou
Gene transfer: manipulating and monitoring function in cells and tissues.
Clinical and experimental pharmacology & physiology 2001;28(8):687-91.
2001: AM Reilly; Steven Petrou; Rekha G Panchal; David A Williams
Restoration of calcium handling properties of adult cardiac myocytes from hypertrophied hearts.
Cell calcium 2001;30(1):59-66.
2001: Robyn H Wallace; Carla Marini; Steven Petrou; Louise A Harkin; David N Bowser; Rekha G Panchal; David A Williams; Grant R Sutherland; John C Mulley; Ingrid E Scheffer; Samuel F Berkovic
Mutant GABA(A) receptor gamma2-subunit in childhood absence epilepsy and febrile seizures.
Nature genetics 2001;28(1):49-52.
2001: Ben J Gu; W Zhang; Rebecca Worthington; Ronald Sluyter; P Dao-Ung; Steven Petrou; Julian A Barden; James S Wiley
A Glu-496 to Ala polymorphism leads to loss of function of the human P2X7 receptor.
The Journal of biological chemistry 2001;276(14):11135-42.
2000: Steven Petrou; David N Bowser; R A Nicholls; Rekha G Panchal; Megan L Smart; AM Reilly; David A Williams
Genetically targeted calcium sensors enhance the study of organelle function in living cells.
Clinical and experimental pharmacology & physiology 2000;27(9):738-44.
1999: David A Williams; David N Bowser; Steven Petrou
Confocal Ca2+ imaging of organelles, cells, tissues, and organs.
Methods in enzymology 1999;307():441-69.
1997: Steven Petrou; M Ugur; Robert M Drummond; Joshua J Singer; John V Walsh
P2X7 purinoceptor expression in Xenopus oocytes is not sufficient to produce a pore-forming P2Z-like phenotype.
FEBS letters 1997;411(2-3):339-45.