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Konstantin Petrukhin

Research Profile

Chemicals & Drugs

Genes & Molecular Sequences

Concepts & Ideas

Disorders

Living Beings

Swine
Mouse

Phenomena

Nucleic Acid Hybridization

Procedures

Anatomy

Kidneys

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Publications

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Qiong Qin; Peter Chase; Nicoleta Dobri; Peter Hodder; Anna Knapinska; Franck Madoux; Konstantin Petrukhin
In pursuit of synthetic modulators for the orphan retina-specific nuclear receptor NR2E3.
Pavel Iserovich; Qiong Qin; Konstantin Petrukhin
DPOFA, a Cl⁻/HCO₃⁻ exchanger antagonist, stimulates fluid absorption across basolateral surface of the retinal pigment epithelium.
Konstantin Petrukhin
New therapeutic targets in atrophic age-related macular degeneration.

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All Publications

2013: Qiong Qin; Peter Chase; Nicoleta Dobri; Peter Hodder; Anna Knapinska; Franck Madoux; Konstantin Petrukhin
In pursuit of synthetic modulators for the orphan retina-specific nuclear receptor NR2E3.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2013;29(3):298-309.
2011: Pavel Iserovich; Qiong Qin; Konstantin Petrukhin
DPOFA, a Cl⁻/HCO₃⁻ exchanger antagonist, stimulates fluid absorption across basolateral surface of the retinal pigment epithelium.
BMC ophthalmology 2011;11():33.
2007: Konstantin Petrukhin
New therapeutic targets in atrophic age-related macular degeneration.
Expert opinion on therapeutic targets 2007;11(5):625-39.
2006: Scott E Wolkenberg; Zhijian Zhao; Marianna Kapitskaya; Andrea L Webber; Konstantin Petrukhin; Yui S Tang; Dennis C Dean; George D Hartman; Craig W Lindsley
Identification of potent agonists of photoreceptor-specific nuclear receptor (NR2E3) and preparation of a radioligand.
Bioorganic & medicinal chemistry letters 2006;16(19):5001-4.
2006: Dorit Raz-Prag; Radha Ayyagari; Robert Fariss; Md Nawajes A Mandal; Vidyullatha Vasireddy; Sharon Majchrzak-Hong; Andrea L Webber; Ronald A Bush; Norman Salem; Konstantin Petrukhin; Paul Sieving
Haploinsufficiency is not the key mechanism of pathogenesis in a heterozygous Elovl4 knockout mouse model of STGD3 disease.
Investigative ophthalmology & visual science 2006;47(8):3603-11.
2006: Marianna Kapitskaya; Michael E Cunningham; Raul Lacson; Oleg Kornienko; Bohumil Bednar; Konstantin Petrukhin
Development of the high throughput screening assay for identification of agonists of an orphan nuclear receptor.
Assay and drug development technologies 2006;4(3):253-62.
2005: Michael E Cunningham; Marianna Kapitskaya; Konstantin Petrukhin; Bohumil Bednar
Preparation and characterization of calibration beads for sorting cells expressing a beta-lactamase gene reporter.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2005;65(2):133-9.
2001: Radha Ayyagari; Kang Zhang; Amy Hutchinson; Z Yu; Anand Swaroop; Laura E Kakuk; J M Seddon; Paul S Bernstein; R A Lewis; Jaana Tammur; Zhenglin Yang; Yingying Li; H Zhang; Beverly M Yashar; Jiafan Liu; Konstantin Petrukhin; Paul Sieving; Rando Allikmets
Evaluation of the ELOVL4 gene in patients with age-related macular degeneration.
Ophthalmic genetics 2001;22(4):233-9.
2001: Paul S Bernstein; Jaana Tammur; Nanda Singh; Amy Hutchinson; M Dixon; C M Pappas; Norman A Zabriskie; Kang Zhang; Konstantin Petrukhin; Mark Leppert; Rando Allikmets
Diverse macular dystrophy phenotype caused by a novel complex mutation in the ELOVL4 gene.
Investigative ophthalmology & visual science 2001;42(13):3331-6.
2001: Johanna M Seddon; Mehran A Afshari; Savitri Sharma; Paul S Bernstein; S Chong; A Hutchinson; Konstantin Petrukhin; Rando Allikmets
Assessment of mutations in the Best macular dystrophy (VMD2) gene in patients with adult-onset foveomacular vitelliform dystrophy, age-related maculopathy, and bull's-eye maculopathy.
Ophthalmology 2001;108(11):2060-7.
2001: Kang Zhang; MF Kniazeva; Min Han; W Li; Z Yu; Zhenglin Yang; Yingying Li; Michael Metzker; Rando Allikmets; Donald J Zack; Laura E Kakuk; Pamela S Lagali; Paul W Wong; Ian M MacDonald; Paul Sieving; David Figueroa; Christopher P Austin; Robert Gould; Radha Ayyagari; Konstantin Petrukhin
A 5-bp deletion in ELOVL4 is associated with two related forms of autosomal dominant macular dystrophy.
Nature genetics 2001;27(1):89-93.
2000: Alan D Marmorstein; Lihua Y Marmorstein; Mary E Rayborn; X Wang; Joe G Hollyfield; Konstantin Petrukhin
Bestrophin, the product of the Best vitelliform macular dystrophy gene (VMD2), localizes to the basolateral plasma membrane of the retinal pigment epithelium.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(23):12758-63.
1999: F Chen; David Figueroa; Alan D Marmorstein; Q Zhang; Konstantin Petrukhin; CT Caskey; Christopher P Austin
Retina-specific nuclear receptor: A potential regulator of cellular retinaldehyde-binding protein expressed in retinal pigment epithelium and Müller glial cells.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(26):15149-54.
1999: Rando Allikmets; J M Seddon; Paul S Bernstein; Amy Hutchinson; A Atkinson; S Sharma; B Gerrard; W Li; Michael Metzker; Claes Wadelius; CT Caskey; M Dean; Konstantin Petrukhin
Evaluation of the Best disease gene in patients with age-related macular degeneration and other maculopathies.
Human genetics 1999;104(6):449-53.
1999: Benjamin Bakall; Towa Marknell; Sofie Ingvast; M J Koisti; Ola Sandgren; W Li; A A Bergen; sten andreasson; Thomas Rosenberg; Konstantin Petrukhin; Claes Wadelius
The mutation spectrum of the bestrophin protein--functional implications.
Human genetics 1999;104(5):383-9.
1998: Meenakshi Noll; Konstantin Petrukhin; Svetlana Lutsenko
Identification of a novel transcription regulator from Proteus mirabilis, PMTR, revealed a possible role of YJAI protein in balancing zinc in Escherichia coli.
The Journal of biological chemistry 1998;273(33):21393-401.
1998: Konstantin Petrukhin; M J Koisti; Benjamin Bakall; W Li; G Xie; Towa Marknell; Ola Sandgren; Kristina Forsman; G Holmgren; sten andreasson; M Vujic; A A Bergen; V McGarty-Dugan; David Figueroa; Christopher P Austin; Michael Metzker; CT Caskey; C Wadelius
Identification of the gene responsible for Best macular dystrophy.
Nature genetics 1998;19(3):241-7.
1997: Svetlana Lutsenko; Konstantin Petrukhin; T Conrad Gilliam; Jack H Kaplan
Heterologous expression of the metal-binding domains of human copper-transporting ATPases (P1-ATPases).
Annals of the New York Academy of Sciences 1997;834():155-7.
1997: A B Shah; I Chernov; H T Zhang; Barbara M Ross; Kamna Das; Svetlana Lutsenko; Enrico Parano; L Pavone; Oleg V Evgrafov; I A Ivanova-Smolenskaya; G Annerén; K Westermark; F H Urrutia; Graciela Penchaszadeh; I Sternlieb; I H Scheinberg; T Conrad Gilliam; Konstantin Petrukhin
Identification and analysis of mutations in the Wilson disease gene (ATP7B): population frequencies, genotype-phenotype correlation, and functional analyses.
American journal of human genetics 1997;61(2):317-28.
1997: Svetlana Lutsenko; Konstantin Petrukhin; MJ Cooper; C T Gilliam; Jack H Kaplan
N-terminal domains of human copper-transporting adenosine triphosphatases (the Wilson's and Menkes disease proteins) bind copper selectively in vivo and in vitro with stoichiometry of one copper per metal-binding repeat.
The Journal of biological chemistry 1997;272(30):18939-44.
1994: Konstantin Petrukhin; T Conrad Gilliam
Genetic disorders of copper metabolism.
Current opinion in pediatrics 1994;6(6):698-701.
1994: Konstantin Petrukhin; Svetlana Lutsenko; I Chernov; Barbara M Ross; Jack H Kaplan; T Conrad Gilliam
Characterization of the Wilson disease gene encoding a P-type copper transporting ATPase: genomic organization, alternative splicing, and structure/function predictions.
Human molecular genetics 1994;3(9):1647-56.
1993: Rudolph E Tanzi; Konstantin Petrukhin; I Chernov; Jean-Luc Pellequer; Wilma Wasco; B Ross; Donna M Romano; Enrico Parano; L Pavone; Linda M Brzustowicz
The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene.
Nature genetics 1993;5(4):344-50.
1993: Konstantin Petrukhin; SG Fischer; M Pirastu; Rudolph E Tanzi; I Chernov; M Devoto; Linda M Brzustowicz; Eftihia Cayanis; E Vitale; James J Russo
Mapping, cloning and genetic characterization of the region containing the Wilson disease gene.
Nature genetics 1993;5(4):338-43.
1993: Konstantin Petrukhin; M C Speer; Eftihia Cayanis; MF Bonaldo; U Tantravahi; MB Soares; SG Fischer; Dorothy Warburton; T Conrad Gilliam; Jurg Ott
A microsatellite genetic linkage map of human chromosome 13.
Genomics 1993;15(1):76-85.
1992: Konstantin Petrukhin; T Conrad Gilliam
Dinucleotide repeat polymorphism at the D19S206 locus.
Human molecular genetics 1992;1(6):454.
1992: Konstantin Petrukhin; T Conrad Gilliam
Dinucleotide repeat polymorphism at the D1S182 locus.
Human molecular genetics 1992;1(6):454.
1992: Konstantin Petrukhin; N N Modyanov; T Conrad Gilliam
Dinucleotide repeat polymorphism at the D4S251 locus.
Human molecular genetics 1992;1(5):349.
1991: nikolai modyanov; Konstantin Petrukhin; VE Sverdlov; A V Grishin; M Y Orlova; Maria B Kostina; O I Makarevich; N E Broude; G S Monastyrskaya; Eugene D Sverdlov
The family of human Na,K-ATPase genes. ATP1AL1 gene is transcriptionally competent and probably encodes the related ion transport ATPase.
FEBS letters 1991;278(1):91-4.
1991: I V Malyshev; D A Bessarab; Konstantin Petrukhin; Stanislav V Volik; N E Broude; G S Monastyrskaya; nikolai modyanov; Eugene D Sverdlov
A comparative analysis of the putative regulatory regions in human genes for the alpha-subunit family of Na(+)-K+ ATPase.
Biomedical science 1991;2(1):54-62.
1990: Iu A Ushkarev; G S Monastyrskaia; N E Broude; N N Nikiforova; D A Bessarab; M Iu Orlova; Konstantin Petrukhin; N N Modianov; Eugene D Sverdlov
[Human Na+,K+-ATPase genes. Gene family and pseudogene for beta-subunit].
Doklady Akademii nauk SSSR 1990;312(2):495-9.
1989: G S Monastyrskaya; N E Broude; N N Nikiforova; D A Bessarab; Konstantin Petrukhin; nikolai modyanov; Eugene D Sverdlov
Human Na+,K+-ATPase genes. Beta-subunit gene family contains at least one gene and one pseudogene.
FEBS letters 1989;257(2):439-42.
1989: Eugene D Sverdlov; D A Bessarab; I V Malyshev; Konstantin Petrukhin; G S Monastyrskaya; N E Broude; nikolai modyanov
Family of human Na+,K+-ATPase genes. Structure of the putative regulatory region of the alpha+-gene.
FEBS letters 1989;244(2):481-3.
1989: A Huth; Konstantin Petrukhin; N N Modyanov; Tom A Rapoport
SRP-dependent membrane integration of the beta-subunit of Na+,K+-ATPase.
Biomedica biochimica acta 1989;48(1):77-84.
1988: Eugene D Sverdlov; N S Akopyanz; Konstantin Petrukhin; N E Broude; G S Monastyrskaya; nikolai modyanov
Na+,K+-ATPase: tissue-specific expression of genes coding for alpha-subunit in diverse human tissues.
FEBS letters 1988;239(1):65-8.
1988: Konstantin Petrukhin; N E Broude; C L Smith
A simple and efficient method for isolating high molecular weight DNA from frozen mammalian tissues.
Nucleic acids research 1988;16(12):5698.
1988: Eugene D Sverdlov; N E Broude; G S Monastyrskaya; VE Sverdlov; A V Grishin; N S Akopyantz; Konstantin Petrukhin; nikolai modyanov
Intraindividual tissue-specific variations in organization of genes coding for the Na,K-ATPase subunits.
Progress in clinical and biological research 1988;268B():135-42.
1988: Eugene D Sverdlov; Konstantin Petrukhin; N S Akop'iants; N E Broude; G S Monastyrskaia
[Differential expression of 2 genes of the Na+,K+-AtPase subunit in normal and tumor tissues in humans].
Doklady Akademii nauk SSSR 1988;298(1):236-9.
1987: Eugene D Sverdlov; N E Broude; VE Sverdlov; G S Monastyrskaya; A V Grishin; Konstantin Petrukhin; N S Akopyanz; nikolai modyanov
Family of Na+,K+-ATPase genes. Intra-individual tissue-specific restriction fragment length polymorphism.
FEBS letters 1987;221(1):129-33.
1987: Eugene D Sverdlov; G S Monastyrskaya; N E Broude; R L Allikmets; A M Melkov; I V Malyshev; I E Dulobova; Konstantin Petrukhin
The family of human Na+,K+-ATPase genes. No less than five genes and/or pseudogenes related to the alpha-subunit.
FEBS letters 1987;217(2):275-8.
1987: G S Monastyrskaya; N E Broude; R L Allikmets; A M Melkov; I V Malyshev; I E Dulubova; Konstantin Petrukhin
The family of human Na+,K+-ATPase genes. A partial nucleotide sequence related to the alpha-subunit.
FEBS letters 1987;213(1):73-80.
1987: N E Broude; G S Monastyrskaia; Konstantin Petrukhin; A V Grishin; N I Kiiatkin
[Primary structure of the beta-subunit of Na+,K+-ATPase from the swine kidney. II. Reverse transcription, cloning of mRNA, complete nucleotide sequence corresponding to the structural region of the gene].
Bioorganicheskaia khimiia 1987;13(1):14-9.
1986: nikolai modyanov; N E Broude; Konstantin Petrukhin; A V Grishin; N M Arzamazova; N A Aldanova; G S Monastyrskaya; Eugene D Sverdlov
Pig kidney Na+,K+-ATPase. Primary structure and spatial organization.
FEBS letters 1986;201(2):237-45.
1986: Iu A Ovchinnikov; N E Broude; Konstantin Petrukhin; A V Grishin; N I Kiiatkin
[Nucleotide sequence of cDNA and primary structure of the NA+,K+-ATPase beta-subunit from the swine kidney].
Doklady Akademii nauk SSSR 1986;287(6):1491-6.
1985: Konstantin Petrukhin; A V Grishin; S G Arsenian; N E Broude; V A Grinkevich
[Problems associated with the use of highly degenerated oligonucleotide probes. Identification of mRNA and cDNA clones corresponding to the gene for the alpha subunit of Na+,K+-ATPase].
Bioorganicheskaia khimiia 1985;11(12):1636-41.
1985: Konstantin Petrukhin; N E Broude; S G Arsenian; A V Grishin; K N Dzhandzhurgazian
[Primary structure of the alpha subunit of Na+,K+-ATPase. II. Isolation, reverse transcription and cloning of messenger RNA].
Bioorganicheskaia khimiia 1985;11(12):1607-13.
1985: Iu A Ovchinnikov; S G Arsenian; N E Broude; Konstantin Petrukhin; A V Grishin
[Nucleotide sequence of cDNA and primary structure of alpha-subunit of Na+,K+-ATPase from the swine kidney].
Doklady Akademii nauk SSSR 1985;285(6):1490-5.
1985: Iu A Ovchinnikov; G S Monastyrskaia; S G Arsenian; N E Broude; Konstantin Petrukhin
[Amino acid sequence of the 17 kDa fragment from the cytoplasmic region of the alpha-subunit of Na+, K+-ATPase].
Doklady Akademii nauk SSSR 1985;283(5):1278-80.