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George Pettit

Research Profile

Chemicals & Drugs

Anatomy

Tumor Cells, Cultured

Living Beings

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TOP 3
George R Pettit; Robin K Pettit; Yuping Tang; Franklin J Ward; Christine Weber; Qingwen Zhang; Christoph A Arm; Gregory T Bourne; Jean-Charles Chapuis; Dennis L Doubek; John C Knight; John E Leet; John N A Hooper
Isolation and structures of axistatins 1-3 from the Republic of Palau marine sponge Agelas axifera Hentschel .
Cheri Lubahn; Noeleen Melody; George R Pettit; Jill A Schaller; Eric Shewmacker; Carlo Wood; Denise L Bellinger; Donna Byron; Dianne Lorton
Preclinical efficacy of sodium narcistatin to reduce inflammation and joint destruction in rats with adjuvant-induced arthritis.
George R Pettit; John C Knight; Ricardo F Mendonça; Bryan R Moser; Fiona Hogan
The cephalostatins. 22. synthesis of bis-steroidal pyrazine pyrones (1).

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2013: George R Pettit; Robin K Pettit; Yuping Tang; Franklin J Ward; Christine Weber; Qingwen Zhang; Christoph A Arm; Gregory T Bourne; Jean-Charles Chapuis; Dennis L Doubek; John C Knight; John E Leet; John N A Hooper
Isolation and structures of axistatins 1-3 from the Republic of Palau marine sponge Agelas axifera Hentschel .
Journal of natural products 2013;76(3):420-4.
2012: Cheri Lubahn; Noeleen Melody; George R Pettit; Jill A Schaller; Eric Shewmacker; Carlo Wood; Denise L Bellinger; Donna Byron; Dianne Lorton
Preclinical efficacy of sodium narcistatin to reduce inflammation and joint destruction in rats with adjuvant-induced arthritis.
Rheumatology international 2012;32(12):3751-60.
2012: George R Pettit; John C Knight; Ricardo F Mendonça; Bryan R Moser; Fiona Hogan
The cephalostatins. 22. synthesis of bis-steroidal pyrazine pyrones (1).
Journal of natural products 2012;75(6):1063-9.
2012: George R Pettit; Rui Tan; Guan-Hu Bao; Jean-Charles Chapuis; Dennis L Doubek; Song Gao; Noeleen Melody; Lee Williams
Antineoplastic agents. 587. Isolation and structure of 3-epipancratistatin from Narcissus cv. Ice Follies.
Journal of natural products 2012;75(4):771-3.
2012: George R Pettit; Robin K Pettit; Heidi J Rosenberg; Brandy Sumner; Kenneth B Ain; Jean-Charles Chapuis; Rachel Dixon; Ernest Hamel; Fiona Hogan; John C Knight; Brindi Trickey-Platt
Antineoplastic agents. 548. Synthesis of iodo- and diiodocombstatin phosphate prodrugs.
Journal of natural products 2012;75(3):385-93.
2011: George R Pettit; John C Knight; Ricardo F Mendonça; Robin K Pettit
The cephalostatins. 21. Synthesis of bis-steroidal pyrazine rhamnosides (1).
Journal of natural products 2011;74(9):1922-30.
2011: Rajendra P Tanpure; Mary Lynn Trawick; Suman Sharma; Bronwyn G Siim; Tracy E Strecker; Savannah Aguirre; David J Chaplin; E Hamel; John W Lippert; Benson L Nguyen; George R Pettit; Kevin G Pinney
Regioselective synthesis of water-soluble monophosphate derivatives of combretastatin A-1.
Journal of natural products 2011;74(7):1568-74.
2011: Ruoli Bai; James C Burnett; Rick Gussio; Murray H G Munro; Tam Luong Nguyen; George R Pettit; Amos B Smith; Onur Atasoylu; Ernest Hamel
Interactions of halichondrin B and eribulin with tubulin.
Journal of chemical information and modeling 2011;51(6):1393-404.
2011: George R Pettit; Thomas H Smith; Jun-Ping Xu; Delbert L Herald; Erik J Flahive; Collin R Anderson; Paul E Belcher; John C Knight
Antineoplastic agents. 590. X-ray crystal structure of dolastatin 16 and syntheses of the dolamethylleuine and dolaphenvaline units.
Journal of natural products 2011;74(5):1003-8.
2011: George R Pettit; Fiona Hogan; Steven Toms
Antineoplastic agents. 592. Highly effective cancer cell growth inhibitory structural modifications of dolastatin 10.
Journal of natural products 2011;74(5):962-8.
2011: Daad Abi Ghanem; Xinzhong Lai; Luc R Berghman; Darijana Horvat; Jing Li; Daniel Romo; Mohammad N Uddin; Yoshiaki Kamano; Toshihiko Nogawa; Jun-Ping Xu; George R Pettit; Jules B Puschett
A chemifluorescent immunoassay for the determination of marinobufagenin in body fluids.
Journal of immunoassay & immunochemistry 2011;32(1):31-46.
2010: George R Pettit; Yanhui Meng; Robin K Pettit; Delbert L Herald; Fiona Hogan; Zbigniew A Cichacz
Antineoplastic agents 582. Part 1: Isolation and structure of a cyclobutane-type sesquiterpene cancer cell growth inhibitor from Coprinus cinereus (Coprinaceae).
Bioorganic & medicinal chemistry 2010;18(14):4879-83.
2010: George R Pettit; Mathew D Minardi; Fiona Hogan; Pat M Price
An efficient synthetic strategy for obtaining 4-methoxy carbon isotope labeled combretastatin A-4 phosphate and other Z-combretastatins.
Journal of natural products 2010;73(3):399-403.
2010: George R Pettit; Yanhui Meng; Robin K Pettit; Delbert L Herald; Zbigniew A Cichacz; Dennis L Doubek; Linda Richert
Antineoplastic agents. 556. Isolation and structure of Coprinastatin 1 from Coprinus cinereus.
Journal of natural products 2010;73(3):388-92.
2010: Ekatherine M Prokopiou; Patricia A Cooper; George R Pettit; Michael C Bibby; Steven D Shnyder
Potentiation of the activity of cisplatin in a human colon tumour xenograft model by auristatin PYE, a structural modification of dolastatin 10.
Molecular medicine reports 2010;3(2):309-13.
2010: Robin K Pettit; George R Pettit; Jung-Ping Xu; Christine A Weber; Linda A Richert
Isolation of human cancer cell growth inhibitory, antimicrobial lateritin from a mixed fungal culture.
Planta medica 2010;76(5):500-1.
2010: George R Pettit; Qinghua Ye; Delbert L Herald; Fiona Hogan; Robin K Pettit
Antineoplastic agents. 573. isolation and structure of papilistatin from the papilionid butterfly Byasa polyeuctes termessa.
Journal of natural products 2010;73(2):164-6.
2009: Robin K Pettit; George R Pettit; Ernest Hamel; Fiona Hogan; Bryan R Moser; Sonja Wolf; Sandy Pon; Jean-Charles Chapuis; Jean M Schmidt
E-Combretastatin and E-resveratrol structural modifications: antimicrobial and cancer cell growth inhibitory beta-E-nitrostyrenes.
Bioorganic & medicinal chemistry 2009;17(18):6606-12.
2009: George R Pettit; Noeleen Melody; Andrew Thornhill; John C Knight; Thomas L Groy; Cherry L Herald
Antineoplastic agents. 579. Synthesis and cancer cell growth evaluation of E-stilstatin 3: a resveratrol structural modification.
Journal of natural products 2009;72(9):1637-42.
2009: Robin K Pettit; Christine A Weber; Stacey B Lawrence; George R Pettit; Melissa J Kean; Gary D Cage
In vivo activity of anprocide alone, and in vitro activity in combination with conventional antibiotics against Staphylococcus aureus and Staphylococcus epidermidis biofilms.
Journal of medical microbiology 2009;58(Pt 9):1203-6.
2009: George R Pettit; Sylvie Ducki; Stephen A Eastham; Noeleen Melody
Antineoplastic agents. 454. Synthesis of the strong cancer cell growth inhibitors trans-dihydronarciclasine and 7-deoxy-trans-dihydronarciclasine (1a).
Journal of natural products 2009;72(7):1279-82.
2009: George R Pettit; Peter D Quistorf; Jeremy A Fry; Delbert L Herald; Ernest Hamel; Jean-Charles Chapuis
Antineoplastic agents. 565. Synthesis of combretastatin D-2 phosphate and dihydro-combretastatin D-2.
Journal of natural products 2009;72(5):876-83.
2009: George R Pettit; Andrew Thornhill; Noeleen Melody; John C Knight
Antineoplastic agents. 578. Synthesis of stilstatins 1 and 2 and their water-soluble prodrugs.
Journal of natural products 2009;72(3):380-8.
2009: George R Pettit; John C Knight; Delbert L Herald; Robin K Pettit; Fiona Hogan; Venugopal J R V Mukku; John S Hamblin; Michael J Dodson; Jean-Charles Chapuis
Antineoplastic agents. 570. Isolation and structure elucidation of bacillistatins 1 and 2 from a marine Bacillus silvestris.
Journal of natural products 2009;72(3):366-71.
2009: George R Pettit; Shougang Hu; John C Knight; Jean-Charles Chapuis
Antineoplastic agents. 571. Total synthesis of bacillistatin 2.
Journal of natural products 2009;72(3):372-9.
2009: Robin K Pettit; Christine A Weber; George R Pettit
Application of a high throughput Alamar blue biofilm susceptibility assay to Staphylococcus aureus biofilms.
Annals of clinical microbiology and antimicrobials 2009;8():28.
2009: Ruoli Bai; Michael Edler; Peter Bonate; Terry D Copeland; George R Pettit; Richard Luduena; Ernest Hamel
Intracellular activation and deactivation of tasidotin, an analog of dolastatin 15: correlation with cytotoxicity.
Molecular pharmacology 2009;75(1):218-26.
2008: A Rudy; Nancy López-Antón; N Barth; George R Pettit; Verena M Dirsch; Klaus Schulze-Osthoff; Markus Rehm; J H M Prehn; M Vogler; S Fulda; Nicole Barth
Role of Smac in cephalostatin-induced cell death.
Cell death and differentiation 2008;15(12):1930-40.
2008: C James; George R Pettit; O F Nielsen; Jayakumar V S; I Hubert Joe
Vibrational spectra and ab initio molecular orbital calculations of the novel anti-cancer drug combretastatin A-4 prodrug.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 2008;70(5):1208-16.
2008: John J Hall; Madhavi Sriram; Tracy E Strecker; Justin K Tidmore; Christopher J Jelinek; G D Kishore Kumar; Mallinath B Hadimani; George R Pettit; David J Chaplin; Mary Lynn Trawick; Kevin G Pinney
Design, synthesis, biochemical, and biological evaluation of nitrogen-containing trifluoro structural modifications of combretastatin A-4.
Bioorganic & medicinal chemistry letters 2008;18(18):5146-9.
2008: George R Pettit; Andrew J Thornhill; Bryan R Moser; Fiona Hogan
Antineoplastic agents. 552. Oxidation of combretastatin A-1: trapping the o-quinone intermediate considered the metabolic product of the corresponding phosphate prodrug.
Journal of natural products 2008;71(9):1561-3.
2008: L Schyschka; A Rudy; I Jeremias; N Barth; George R Pettit; Nicole Barth
Spongistatin 1: a new chemosensitizing marine compound that degrades XIAP.
Leukemia 2008;22(9):1737-45.
2008: George R Pettit; Fiona Hogan; Jun-Ping Xu; Rui Tan; Toshihiko Nogawa; Zbigniew A Cichacz; Robin K Pettit; Jiang Du; Qing-Hua Ye; Gordon M Cragg; Cherry L Herald; Michael S Hoard; Animesh Goswami; Justin Searcy; Larry P Tackett; Dennis L Doubek; Lee Williams; John N A Hooper; Jean M Schmidt; Jean-Charles Chapuis; Denise N Tackett; Felicia Craciunescu
Antineoplastic agents. 536. New sources of naturally occurring cancer cell growth inhibitors from marine organisms, terrestrial plants, and microorganisms(1a,).
Journal of natural products 2008;71(3):438-44.
2008: Rogelio Siles; J Freeland Ackley; Mallinath B Hadimani; John J Hall; Benon E Mugabe; Rajsekhar Guddneppanavar; Keith A Monk; Jean-Charles Chapuis; George R Pettit; David J Chaplin; Klaus Edvardsen; Mary Lynn Trawick; Charles M Garner; Kevin G Pinney
Combretastatin dinitrogen-substituted stilbene analogues as tubulin-binding and vascular-disrupting agents.
Journal of natural products 2008;71(3):313-20.
2008: Mary R Brennan; Catherine E Costello; Simin D Maleknia; George R Pettit; KL Erickson
Stylopeptide 2, a proline-rich cyclodecapeptide from the sponge Stylotella sp.
Journal of natural products 2008;71(3):453-6.
2008: Amos B Smith; Thomas M Razler; Regina M Meis; George R Pettit
Synthesis and biological evaluation of phorboxazole congeners leading to the discovery and preparative-scale synthesis of (+)-chlorophorboxazole a possessing picomolar human solid tumor cell growth inhibitory activity.
The Journal of organic chemistry 2008;73(4):1201-8.
2008: K K Repp; Fiona Hogan; George R Pettit; Robin K Pettit
In vitro interactions of approved and experimental drugs against Candida drugs against Candida spp.
Journal of chemotherapy (Florence, Italy) 2008;20(1):137-9.
2008: George R Pettit; Venugopal J R V Mukku; Gordon M Cragg; Delbert L Herald; John C Knight; Cherry L Herald; Jean-Charles Chapuis
Antineoplastic agents. 558. Ampelocissus sp. cancer cell growth inhibitory constituents.
Journal of natural products 2008;71(1):130-3.
2007: Steven D Shnyder; Patricia A Cooper; Nicola J Millington; George R Pettit; Michael C Bibby
Auristatin PYE, a novel synthetic derivative of dolastatin 10, is highly effective in human colon tumour models.
International journal of oncology 2007;31(2):353-60.
2007: George R Pettit; Thomas H Smith; Song Feng; John C Knight; Rui Tan; Robin K Pettit; Peter A Hinrichs
Antineoplastic agents. 561. Total synthesis of respirantin.
Journal of natural products 2007;70(7):1073-83.
2007: George R Pettit; Rui Tan; Robin K Pettit; Thomas H Smith; Song Feng; Dennis L Doubek; Linda Richert; John Hamblin; Christine Weber; Jean-Charles Chapuis
Antineoplastic agents. 560. Isolation and structure of kitastatin 1 from an Alaskan Kitasatospora sp.
Journal of natural products 2007;70(7):1069-72.
2007: George R Pettit; Noeleen Melody; Delbert L Herald; John C Knight; Jean-Charles Chapuis
Antineoplastic agents. 550. Synthesis of 10b(s)-epipancratistatin from (+)-narciclasine.
Journal of natural products 2007;70(3):417-22.
2006: Donnette A Dabydeen; James C Burnett; Ruoli Bai; Pascal Verdier-Pinard; Sarah J H Hickford; George R Pettit; John W Blunt; Murray H G Munro; Rick Gussio; Ernest Hamel
Comparison of the activities of the truncated halichondrin B analog NSC 707389 (E7389) with those of the parent compound and a proposed binding site on tubulin.
Molecular pharmacology 2006;70(6):1866-75.
2006: Nancy López-Antón; Anita Rudy; Nicole Barth; M Lienhard Schmitz; Lienhard M Schmitz; George R Pettit; Klaus Schulze-Osthoff; Verena M Dirsch; Nicole Barth
The marine product cephalostatin 1 activates an endoplasmic reticulum stress-specific and apoptosome-independent apoptotic signaling pathway.
The Journal of biological chemistry 2006;281(44):33078-86.
2006: Heather L. LaMarca; Cindy A Morris; George R Pettit; T Nagowa; Jules B Puschett
Marinobufagenin impairs first trimester cytotrophoblast differentiation.
Placenta 2006;27(9-10):984-8.
2006: George R Pettit; Jiang Du; Robin K Pettit; Linda A Richert; Fiona Hogan; Venugopal J R V Mukku; Michael S Hoard
Antineoplastic Agents. 554. The manitoba bacterium Streptomyces sp.
Journal of natural products 2006;69(5):804-6.
2006: Keith A Monk; Rogelio Siles; Mallinath B Hadimani; Benon E Mugabe; J Freeland Ackley; Scott W Studerus; Klaus Edvardsen; Mary Lynn Trawick; Charles M Garner; Monte R Rhodes; George R Pettit; Kevin G Pinney
Design, synthesis, and biological evaluation of combretastatin nitrogen-containing derivatives as inhibitors of tubulin assembly and vascular disrupting agents.
Bioorganic & medicinal chemistry 2006;14(9):3231-44.
2006: George R Pettit; Atsushi Numata; Chika Iwamoto; Yoshihide Usami; Takeshi Yamada; Hirofumi Ohishi; Gordon M Cragg
Antineoplastic agents. 551. Isolation and structures of bauhiniastatins 1-4 from Bauhinia purpurea.
Journal of natural products 2006;69(3):323-7.
2006: Amos B Smith; Thomas M Razler; Regina M Meis; George R Pettit
Design and synthesis of a potent phorboxazole C(11-15) acetal analogue.
Organic letters 2006;8(4):797-9.
2006: Hop Vu; Monica Ianosi-Irimie; Svitlana Danchuk; Edd Rabon; Toshihiko Nogawa; Yoshiaki Kamano; George R Pettit; Thomas Wiese; Jules B Puschett
Resibufogenin corrects hypertension in a rat model of human preeclampsia.
Experimental biology and medicine (Maywood, N.J.) 2006;231(2):215-20.
2006: George R Pettit; Stephen A Eastham; Noeleen Melody; Brian Orr; Delbert L Herald; Jane McGregor; John C Knight; Dennis L Doubek; George R Pettit; Lynnette C Garner; Joy A Bell
Isolation and structural modification of 7-deoxynarciclasine and 7-deoxy-trans-dihydronarciclasine.
Journal of natural products 2006;69(1):7-13.
2005: George R Pettit; Mathew D Minardi; Heidi J Rosenberg; Ernest Hamel; Michael C Bibby; Sandie W Martin; M Katherine Jung; Robin K Pettit; Timothy J Cuthbertson; Jean-Charles Chapuis
Antineoplastic agents. 509: synthesis of fluorcombstatin phosphate and related 3-halostilbenes(1).
Journal of natural products 2005;68(10):1450-8.
2005: Amos B Smith; Thomas M Razler; George R Pettit; Jean-Charles Chapuis
(+)-Phorboxazole A synthetic studies. Identification of a series of highly cytotoxic C(45-46) analogues.
Organic letters 2005;7(20):4403-6.
2005: Robin K Pettit; Tanja Woyke; Sandy Pon; Zbigniew A Cichacz; George R Pettit; Cherry L Herald
In vitro and in vivo antifungal activities of the marine sponge constituent spongistatin.
Medical mycology : official publication of the International Society for Human and Animal Mycology 2005;43(5):453-63.
2005: George R Pettit; Yanhui Meng; Delbert L Herald; John C Knight; John F Day
Antineoplastic agents. 553. The Texas grasshopper Brachystola magna.
Journal of natural products 2005;68(8):1256-8.
2005: George R Pettit; Rui Tan; Zbigniew A Cichacz
Antineoplastic agents. 542. Isolation and structure of sesterstatin 6 from the Indian Ocean sponge Hyrtios erecta.
Journal of natural products 2005;68(8):1253-5.
2005: George R Pettit; Collin R Anderson; Eric J Gapud; M Katherine Jung; John C Knight; Ernest Hamel; Robin K Pettit
Antineoplastic agents. 515. Synthesis of human cancer cell growth inhibitors derived from 3,4-methylenedioxy-5,4'-dimethoxy-3'-amino-Z-stilbene.
Journal of natural products 2005;68(8):1191-7.
2005: George R Pettit; Yuping Tang; John C Knight
Antineoplastic agents. 545. Isolation and structure of turbostatins 1-4 from the Asian marine mollusk Turbo stenogyrus.
Journal of natural products 2005;68(7):974-8.
2005: Robin K Pettit; Christine A Weber; Melissa J Kean; Holger Hoffmann; George R Pettit; Rui Tan; Kelly S Franks; Marilyn L Horton
Microplate Alamar blue assay for Staphylococcus epidermidis biofilm susceptibility testing.
Antimicrobial agents and chemotherapy 2005;49(7):2612-7.
2005: Md Ahad Ali; Robert B Bates; Zackary D Crane; Christopher W Dicus; Michelle R Gramme; Ernest Hamel; Jacob Marcischak; David S Martinez; Kelly J McClure; Pichaya Nakkiew; George R Pettit; Chad C Stessman; Bilal A Sufi; Gayle V Yarick
Dolastatin 11 conformations, analogues and pharmacophore.
Bioorganic & medicinal chemistry 2005;13(13):4138-52.
2005: George R Pettit; Monte R Rhodes; Delbert L Herald; Ernest Hamel; Jean M Schmidt; Robin K Pettit
Antineoplastic agents. 445. Synthesis and evaluation of structural modifications of (Z)- and (E)-combretastatin A-41.
Journal of medicinal chemistry 2005;48(12):4087-99.
2005: George R Pettit; Qingwen Zhang; Veronique Pinilla; Holger Hoffmann; John C Knight; Dennis L Doubek; Jean-Charles Chapuis; Robin K Pettit; Jean M Schmidt
Antineoplastic agents. 534. isolation and structure of sansevistatins 1 and 2 from the African Sansevieria ehrenbergii.
Journal of natural products 2005;68(5):729-33.
2005: Irina M Müller; Verena M Dirsch; Anita Rudy; Nancy López-Antón; George R Pettit; Angelika M Vollmar
Cephalostatin 1 inactivates Bcl-2 by hyperphosphorylation independent of M-phase arrest and DNA damage.
Molecular pharmacology 2005;67(5):1684-9.
2005: George R Pettit; Noeleen Melody
Antineoplastic agents. 527. Synthesis of 7-deoxynarcistatin, 7-deoxy-trans-dihydronarcistatin, and trans-dihydronarcistatin 1(1).
Journal of natural products 2005;68(2):207-11.
2005: George R Pettit; Yanhui Meng; Delbert L Herald; Andrew M Stevens; Robin K Pettit; Dennis L Doubek
Antineoplastic agents 540. The Indian Gynandropsis gynandra (Capparidaceae).
Oncology research 2005;15(2):59-68.
2005: George R Pettit; Sylvie Ducki; Delbert L Herald; Dennis L Doubek; Jean M Schmidt; Jean-Charles Chapuis
Antineoplastic agents 470. Absolute configuration of the marine sponge bromopyrrole agelastatin A.
Oncology research 2005;15(1):11-20.
2005: George R Pettit; Rui Tan
Isolation and structure of phakellistatin 14 from the Western Pacific marine sponge Phakellia sp.
Journal of natural products 2005;68(1):60-3.
2004: Uwe Rinner; Tomas Hudlicky; Heather Gordon; George R Pettit
A beta-carboline-1-one mimic of the anticancer Amaryllidaceae constituent pancratistatin: synthesis and biological evaluation.
Angewandte Chemie (International ed. in English) 2004;43(40):5342-6.
2004: Marie Suggitt; David J Swaine; George R Pettit; Michael C Bibby
Characterization of the hollow fiber assay for the determination of microtubule disruption in vivo.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(19):6677-85.
2004: George R Pettit; Toshihiko Nogawa; John C Knight; Dennis L Doubek; John N A Hooper
Antineoplastic agents. 535. Isolation and structure of plakorstatins 1 and 2 from the Indo-Pacific sponge Plakortis nigra.
Journal of natural products 2004;67(9):1611-3.
2004: George R Pettit; Rui Tan; Julian S Northen; Delbert L Herald; Jean-Charles Chapuis; Robin K Pettit
Antineoplastic agents. 529. Isolation and structure of nootkastatins 1 and 2 from the Alaskan yellow cedar Chamaecyparis nootkatensis.
Journal of natural products 2004;67(9):1476-82.
2004: George R Pettit; Jun-Ping Xu; Dennis L Doubek; Jean-Charles Chapuis; Jean M Schmidt
Antineoplastic Agents. 510. Isolation and structure of dolastatin 19 from the Gulf of California sea hare Dolabella auricularia.
Journal of natural products 2004;67(8):1252-5.
2004: Ruoli Bai; David G Covell; George F Taylor; John A Kepler; Terry D Copeland; Nga Y Nguyen; George R Pettit; Ernest Hamel
Direct photoaffinity labeling by dolastatin 10 of the amino-terminal peptide of beta-tubulin containing cysteine 12.
The Journal of biological chemistry 2004;279(29):30731-40.
2004: George R Pettit; Fiona Hogan; Delbert L Herald
Synthesis and X-ray crystal structure of the dolabellaauricularia peptide dolastatin 18.
The Journal of organic chemistry 2004;69(12):4019-22.
2004: Uwe Rinner; Heather L Hillebrenner; David R Adams; Tomas Hudlicky; George R Pettit
Synthesis and biological activity of some structural modifications of pancratistatin.
Bioorganic & medicinal chemistry letters 2004;14(11):2911-5.
2004: George R Pettit; Qingwen Zhang; Véronique Pinilla; Delbert L Herald; Dennis L Doubek; James A Duke
Isolation and structure of gustastatin from the Brazilian nut tree Gustavia hexapetala.
Journal of natural products 2004;67(6):983-5.
2004: George R Pettit; Holger Hoffmann; Delbert L Herald; James McNulty; Alison Murphy; Kerianne C Higgs; Ernest Hamel; Nancy E Lewin; Larry V Pearce; Peter M Blumberg; Robin K Pettit; John C Knight
Antineoplastic agents 491. Synthetic conversion of aaptamine to isoaaptamine, 9-demethylaaptamine, and 4-methylaaptamine.
The Journal of organic chemistry 2004;69(7):2251-6.
2004: George R Pettit; Holger Hoffmann; Delbert L Herald; Peter M Blumberg; Ernest Hamel; Jean M Schmidt; Yung Chang; Robin K Pettit; Nancy E Lewin; Larry V Pearce
Antineoplastic agents. 499. Synthesis of hystatin 2 and related 1H-benzo[de][1,6]-naphthyridinium salts from aaptamine.
Journal of medicinal chemistry 2004;47(7):1775-82.
2004: George R Pettit; Holger Hoffmann; James McNulty; Kerianne C Higgs; Alison Murphy; David J Molloy; Delbert L Herald; Michael D Williams; Robin K Pettit; Dennis L Doubek; John N A Hooper; Leslie Albright; Jean M Schmidt; Jean-Charles Chapuis; Larry P Tackett
Antineoplastic agents. 380. Isolation and X-ray crystal structure determination of isoaaptamine from the Republic of Singapore Hymeniacidon sp. and conversion to the phosphate prodrug hystatin 1.
Journal of natural products 2004;67(3):506-9.
2004: George R Pettit; Noeleen Melody; Delbert L Herald
Antineoplastic agents. 511. Direct phosphorylation of phenpanstatin and pancratistatin.
Journal of natural products 2004;67(3):322-7.
2004: Long H Dang; Chetan Bettegowda; Nishant Agrawal; Ian Cheong; David L Huso; Philip Frost; Frank Loganzo; Lee M Greenberger; Jozsef Barkoczy; George R Pettit; Amos B Smith; Hallur Gurulingappa; Saeed R Khan; Giovanni Parmigiani; Kenneth W Kinzler; Shibin Zhou; Bert Vogelstein
Targeting vascular and avascular compartments of tumors with C. novyi-NT and anti-microtubule agents.
Cancer biology & therapy 2004;3(3):326-37.
2004: George R Pettit; Jun-Ping Xu; Jean-Charles Chapuis; Robin K Pettit; Larry P Tackett; Dennis L Doubek; John N A Hooper; Jean M Schmidt
Antineoplastic agents. 520. Isolation and structure of irciniastatins A and B from the Indo-Pacific marine sponge Ircinia ramosa.
Journal of medicinal chemistry 2004;47(5):1149-52.
2004: Ian G Kirwan; Paul M Loadman; David J Swaine; D Alan Anthoney; George R Pettit; John W Lippert; Steven D Shnyder; Patricia A Cooper; Michael C Bibby
Comparative preclinical pharmacokinetic and metabolic studies of the combretastatin prodrugs combretastatin A4 phosphate and A1 phosphate.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(4):1446-53.
2004: George R Pettit; Yanhui Meng; R Patrick Gearing; Delbert L Herald; Robin K Pettit; Dennis L Doubek; Jean-Charles Chapuis; Larry P Tackett
Antineoplastic agents. 522. Hernandia peltata (Malaysia) and Hernandia nymphaeifolia (Republic of Maldives).
Journal of natural products 2004;67(2):214-20.
2004: Tanja Woyke; Michael Berens; Dominique Hoelzinger; George R Pettit; Günther Winkelmann; Robin K Pettit
Differential gene expression in auristatin PHE-treated Cryptococcus neoformans.
Antimicrobial agents and chemotherapy 2004;48(2):561-7.
2004: Robin K Pettit; Bridget R Fakoury; John C Knight; Christine A Weber; George R Pettit; Gary D Cage; Sandy Pon
Antibacterial activity of the marine sponge constituent cribrostatin 6.
Journal of medical microbiology 2004;53(Pt 1):61-5.
2003: Verena M Dirsch; Irina M Müller; Sören Eichhorst; George R Pettit; Yoshiaki Kamano; Masuo Inoue; Jun-Ping Xu; Yoshitatsu Ichihara; Gerhard Wanner; Angelika M Vollmar
Cephalostatin 1 selectively triggers the release of Smac/DIABLO and subsequent apoptosis that is characterized by an increased density of the mitochondrial matrix.
Cancer research 2003;63(24):8869-76.
2003: Zobeida Cruz-Monserrate; Jeffrey T Mullaney; Patrick G Harran; George R Pettit; Ernest Hamel
Dolastatin 15 binds in the vinca domain of tubulin as demonstrated by Hummel-Dreyer chromatography.
European journal of biochemistry / FEBS 2003;270(18):3822-8.
2003: Shadan Ali; Olivia Aranha; Yiwei Li; George R Pettit; Asfar S Azmi; Philip A Philip
Sensitization of human breast cancer cells to gemcitabine by the protein kinase C modulator bryostatin 1.
Cancer chemotherapy and pharmacology 2003;52(3):235-46.
2003: George R Pettit; Yanhui Meng; Delbert L Herald; Keith A N Graham; Robin K Pettit; Dennis L Doubek
Isolation and structure of ruprechstyril from Ruprechtia tangarana.
Journal of natural products 2003;66(8):1065-9.
2003: Zobeida Cruz-Monserrate; Hélène C Vervoort; Ruoli Bai; David Newman; Stephen B Howell; Gerrit Los; Jeffrey T Mullaney; Michael D Williams; George R Pettit; William Fenical; Ernest Hamel
Diazonamide A and a synthetic structural analog: disruptive effects on mitosis and cellular microtubules and analysis of their interactions with tubulin.
Molecular pharmacology 2003;63(6):1273-80.
2003: George R Pettit; Jeremiah C Collins; John C Knight; Delbert L Herald; Ronald A Nieman; Michael D Williams; Robin K Pettit
Antineoplastic agents. 485. Isolation and structure of cribrostatin 6, a dark blue cancer cell growth inhibitor from the marine sponge Cribrochalina sp.
Journal of natural products 2003;66(4):544-7.
2003: B J Fennell; S Carolan; George R Pettit; Angus Bell
Effects of the antimitotic natural product dolastatin 10, and related peptides, on the human malarial parasite Plasmodium falciparum.
The Journal of antimicrobial chemotherapy 2003;51(4):833-41.
2003: Steven D Shnyder; Patricia A Cooper; George R Pettit; John W Lippert; Michael C Bibby
Combretastatin A-1 phosphate potentiates the antitumour activity of cisplatin in a murine adenocarcinoma model.
Anticancer research 2003;23(2B):1619-23.
2003: Jianyi Hua; Yezhou Sheng; Kevin G Pinney; Charles M Garner; Robert Kane; Joseph A Prezioso; George R Pettit; David J Chaplin; Klaus Edvardsen
Oxi4503, a novel vascular targeting agent: effects on blood flow and antitumor activity in comparison to combretastatin A-4 phosphate.
Anticancer research 2003;23(2B):1433-40.
2003: George R Pettit; Rui Tan
Antineoplastic agents 390. Isolation and structure of phakellistatin 12 from a Chuuk archipelago marine sponge.
Bioorganic & medicinal chemistry letters 2003;13(4):685-8.
2003: George R Pettit; Collin R Anderson; Delbert L Herald; M Katherine Jung; Debbie J Lee; Ernest Hamel; Robin K Pettit
Antineoplastic agents. 487. Synthesis and biological evaluation of the antineoplastic agent 3,4-methylenedioxy-5,4'-dimethoxy-3'-amino-Z-stilbene and derived amino acid amides.
Journal of medicinal chemistry 2003;46(4):525-31.
2003: George R Pettit; Rui Tan; Delbert L Herald; John Hamblin; Robin K Pettit
Antineoplastic agents. 488. Isolation and structure of yukonin from a yukon territory fungus.
Journal of natural products 2003;66(2):276-8.
2003: George R Pettit; Yanhui Meng; Clare A Stevenson; Dennis L Doubek; John C Knight; Zbigniew A Cichacz; Robin K Pettit; Jean-Charles Chapuis; Jean M Schmidt
Isolation and structure of palstatin from the Amazon tree Hymeneae palustris(1).
Journal of natural products 2003;66(2):259-62.
2003: George R Pettit; Noeleen Melody; Michael Simpson; Michael Thompson; Delbert L Herald; John C Knight
Antineoplastic agents 500. Narcistatin.
Journal of natural products 2003;66(1):92-6.
2002: Tomas Hudlicky; Uwe Rinner; David Gonzalez; Hulya Akgun; Stefan Schilling; Peter Siengalewicz; Theodore A Martinot; George R Pettit
Total synthesis and biological evaluation of Amaryllidaceae alkaloids: narciclasine, ent-7-deoxypancratistatin, regioisomer of 7-deoxypancratistatin, 10b-epi-deoxypancratistatin, and truncated derivatives.
The Journal of organic chemistry 2002;67(25):8726-43.
2002: Yoshiaki Kamano; Ayano Yamashita; Toshihiko Nogawa; Hiroshi Morita; Koichi Takeya; Hideji Itokawa; Toshiaki Segawa; Ayako Yukita; Kyoko Saito; Mariko Katsuyama; George R Pettit
QSAR evaluation of the Ch'an Su and related bufadienolides against the colchicine-resistant primary liver carcinoma cell line PLC/PRF/5(1).
Journal of medicinal chemistry 2002;45(25):5440-7.
2002: George R Pettit; Atsushi Numata; Chika Iwamoto; Hideaki Morito; Takeshi Yamada; Animesh Goswami; Paul J Clewlow; Gordon M Cragg; Jean M Schmidt
Antineoplastic agents. 489. Isolation and structures of meliastatins 1-5 and related euphane triterpenes from the tree Melia dubia.
Journal of natural products 2002;65(12):1886-91.
2002: Ruoli Bai; Robert B Bates; Ernest Hamel; Richard E Moore; Pichaya Nakkiew; George R Pettit; Bilal A Sufi
Lyngbyastatin 1 and Ibu-epilyngbyastatin 1: synthesis, stereochemistry, and NMR line broadening.
Journal of natural products 2002;65(12):1824-9.
2002: George R Pettit; John C Knight; Delbert L Herald; Richard Davenport; Robin K Pettit; Bruce E Tucker; Jean M Schmidt
Isolation of labradorins 1 and 2 from Pseudomonas syringae pv. coronafaciens.
Journal of natural products 2002;65(12):1793-7.
2002: Tanja Woyke; Robert W Roberson; George R Pettit; Günther Winkelmann; Robin K Pettit
Effect of auristatin PHE on microtubule integrity and nuclear localization in Cryptococcus neoformans.
Antimicrobial agents and chemotherapy 2002;46(12):3802-8.
2002: SE Holwell; Patricia A Cooper; M J Thompson; George R Pettit; L W Lippert; Sandie W Martin; Michael C Bibby
Anti-tumor and anti-vascular effects of the novel tubulin-binding agent combretastatin A-1 phosphate.
Anticancer research 2002;22(6C):3933-40.
2002: George R Pettit; Sylvie Ducki; Rui Tan; Roberta S Gardella; James B McMahon; Michael R Boyd; George R Pettit; Peter M Blumberg; Nancy E Lewin; Dennis L Doubek; Larry P Tackett; Michael D Williams
Isolation and structure of pedilstatin from a republic of maldives Pedilanthus sp.
Journal of natural products 2002;65(9):1262-5.
2002: Amos B Smith; R Michael Corbett; George R Pettit; Jean-Charles Chapuis; Jean M Schmidt; Ernest Hamel; M Katherine Jung
Synthesis and biological evaluation of a spongistatin AB-spiroketal analogue.
Bioorganic & medicinal chemistry letters 2002;12(15):2039-42.
2002: Sanaa M Nabha; Ramzi M Mohammad; Mahmoud H Dandashi; Brigitte Coupaye-Gerard; Amro Aboukameel; George R Pettit; Ayad Al-Katib
Combretastatin-A4 prodrug induces mitotic catastrophe in chronic lymphocytic leukemia cell line independent of caspase activation and poly(ADP-ribose) polymerase cleavage.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(8):2735-41.
2002: Yoshiaki Kamano; Toshihiko Nogawa; Ayano Yamashita; Masahiko Hayashi; Masuo Inoue; Pavel Drasar; George R Pettit
Isolation and structure of a 20,21-epoxybufenolide series from "Ch'an Su".
Journal of natural products 2002;65(7):1001-5.
2002: George R Pettit; Matthew P Grealish; M Katherine Jung; Ernest Hamel; Robin K Pettit; Jean-Charles Chapuis; Jean M Schmidt
Antineoplastic agents. 465. Structural modification of resveratrol: sodium resverastatin phosphate.
Journal of medicinal chemistry 2002;45(12):2534-42.
2002: Sally A Hill; Gillian M Toze; George R Pettit; David J Chaplin
Preclinical evaluation of the antitumour activity of the novel vascular targeting agent Oxi 4503.
Anticancer research 2002;22(3):1453-8.
2002: Robin K Pettit; Ernest Hamel; P Verdier-Pinard; Robert W Roberson; K C Hazen; George R Pettit; Laura C Crews
Antifungal and cancer cell growth inhibitory activities of 1-(3',4',5'-trimethoxyphenyl)-2-nitro-ethylene.
Mycoses 2002;45(3-4):65-74.
2002: SE Holwell; Patricia A Cooper; Konstantina Grosios; John W Lippert; George R Pettit; Steven D Shnyder; Michael C Bibby
Combretastatin A-1 phosphate a novel tubulin-binding agent with in vivo anti vascular effects in experimental tumours.
Anticancer research 2002;22(2A):707-11.
2002: Douglas Thamm; E Gregory MacEwen; Brenda S Phillips; A Elizabeth Hershey; Kristine M Burgess; George R Pettit; David M Vail
Preclinical study of dolastatin-10 in dogs with spontaneous neoplasia.
Cancer chemotherapy and pharmacology 2002;49(3):251-5.
2001: George R Pettit; Matthew P Grealish
A cobalt-phosphine complex directed Reformatsky approach to a stereospecific synthesis of the dolastatin 10 unit dolaproine (Dap).
The Journal of organic chemistry 2001;66(25):8640-2.
2001: Amos B Smith; Young Shin Cho; L E Zawacki; Ralph Hirschmann; George R Pettit
First generation design, synthesis, and evaluation of azepine-based cryptophycin analogues.
Organic letters 2001;3(25):4063-6.
2001: Tanja Woyke; George R Pettit; Günther Winkelmann; Robin K Pettit
In vitro activities and postantifungal effects of the potent dolastatin 10 derivative auristatin PHE.
Antimicrobial agents and chemotherapy 2001;45(12):3580-4.
2001: M Ouarzane-Amara; Jean-François Franetich; Dominique Mazier; George R Pettit; L Meijer; Christian Doerig; Isabelle Desportes-Livage
In vitro activities of two antimitotic compounds, pancratistatin and 7-deoxynarciclasine, against Encephalitozoon intestinalis, a microsporidium causing infections in humans.
Antimicrobial agents and chemotherapy 2001;45(12):3409-15.
2001: Ramzi M Mohammad; N Volkan Adsay; Philip A Philip; George R Pettit; Vainutis K Vaitkevicius; Asfar S Azmi
Bryostatin 1 induces differentiation and potentiates the antitumor effect of Auristatin PE in a human pancreatic tumor (PANC-1) xenograft model.
Anti-cancer drugs 2001;12(9):735-40.
2001: Toshihiko Nogawa; Yoshiaki Kamano; Ayano Yamashita; George R Pettit
Isolation and structure of five new cancer cell growth inhibitory bufadienolides from the Chinese traditional drug Ch'an Su.
Journal of natural products 2001;64(9):1148-52.
2001: George R Pettit; B R Moser; Michael R Boyd; Jean M Schmidt; Robin K Pettit; Jean-Charles Chapuis
Antineoplastic agents 460. Synthesis of combretastatin A-2 prodrugs.
Anti-cancer drug design 2001;16(4-5):185-93.
2001: George R Pettit; JW Lippert; S R Taylor; Rui Tan; Michael D Williams
Synthesis of phakellistatin 11: a micronesia (Chuuk) marine sponge cyclooctapeptide.
Journal of natural products 2001;64(7):883-91.
2001: George R Pettit; Noeleen Melody; Delbert L Herald
Antineoplastic agents. 450. Synthesis of (+)-pancratistatin from (+)-narciclasine as relay(1a).
The Journal of organic chemistry 2001;66(8):2583-7.
2001: J J Duffield; George R Pettit
Synthesis of (7S,15S)- and (7R,15S)-dolatrienoic acid.
Journal of natural products 2001;64(4):472-9.
2001: Ruoli Bai; Pascal Verdier-Pinard; S Gangwar; Chad C Stessman; K J McClure; Edward A Sausville; George R Pettit; Robert B Bates; Ernest Hamel
Dolastatin 11, a marine depsipeptide, arrests cells at cytokinesis and induces hyperpolymerization of purified actin.
Molecular pharmacology 2001;59(3):462-9.
2001: James McNulty; J Mao; R Gibe; R Mo; S Wolf; George R Pettit; Delbert L Herald; Michael R Boyd
Studies directed towards the refinement of the pancratistatin cytotoxic pharmacophore.
Bioorganic & medicinal chemistry letters 2001;11(2):169-72.
2001: Sanaa M Nabha; Ramzi M Mohammad; Nathan Wall; JA Dutcher; B M Salkini; George R Pettit; Ayad Al-Katib
Evaluation of combretastatin A-4 prodrug in a non-Hodgkin's lymphoma xenograft model: preclinical efficacy.
Anti-cancer drugs 2001;12(1):57-63.
2000: Z Chen; V P Mocharla; J M Farmer; George R Pettit; E Hamel; Kevin G Pinney
Preparation of new anti-tubulin ligands through a dual-mode, addition-elimination reaction to a bromo-substituted alpha, beta-unsaturated sulfoxide.
The Journal of organic chemistry 2000;65(25):8811-5.
2000: George R Pettit; M D Minardi; Michael R Boyd; Robin K Pettit
Antineoplastic agents 463. Synthesis of combretastatin A-3 diphosphate prodrugs.
Anti-cancer drug design 2000;15(6):397-403.
2000: George R Pettit; B Orr; Sylvie Ducki
Antineoplastic agents 453. Synthesis of pancratistatin prodrugs.
Anti-cancer drug design 2000;15(6):389-95.
2000: H Clarke; N Ginanni; KV Laughlin; J B Smith; George R Pettit; James M Mullin
The transient increase of tight junction permeability induced by bryostatin 1 correlates with rapid downregulation of protein kinase C-alpha.
Experimental cell research 2000;261(1):239-49.
2000: George R Pettit; JW Lippert; Delbert L Herald
A pinacol rearrangement/oxidation synthetic route to hydroxyphenstatin.
The Journal of organic chemistry 2000;65(22):7438-44.
2000: George R Pettit; JW Lippert; Michael R Boyd; P Verdier-Pinard; Ernest Hamel
Antineoplastic agents 442. Synthesis and biological activities of dioxostatin.
Anti-cancer drug design 2000;15(5):361-71.
2000: Kevin G Pinney; M P Mejia; Victor Manuel Villalobos; B E Rosenquist; George R Pettit; P Verdier-Pinard; E Hamel
Synthesis and biological evaluation of aryl azide derivatives of combretastatin A-4 as molecular probes for tubulin.
Bioorganic & medicinal chemistry 2000;8(10):2417-25.
2000: Catheryne Chen; Hong Lin; Chatchada Karanes; George R Pettit; Ben D Chen
Human THP-1 monocytic leukemic cells induced to undergo monocytic differentiation by bryostatin 1 are refractory to proteasome inhibitor-induced apoptosis.
Cancer research 2000;60(16):4377-85.
2000: Robin K Pettit; G D Cage; George R Pettit; J A Liebman
Antimicrobial and cancer cell growth inhibitory activities of 3beta-acetoxy-17beta-(L-prolyl)amino-5alpha-androstane in vitro.
International journal of antimicrobial agents 2000;15(4):299-304.
2000: George R Pettit; Matthew P Grealish; Delbert L Herald; Michael R Boyd; Ernest Hamel; Robin K Pettit
Antineoplastic agents. 443. Synthesis of the cancer cell growth inhibitor hydroxyphenstatin and its sodium diphosphate prodrug.
Journal of medicinal chemistry 2000;43(14):2731-7.
2000: George R Pettit; JW Lippert; Delbert L Herald; Ernest Hamel; Robin K Pettit
Antineoplastic agents 440. Asymmetric synthesis and evaluation of the combretastatin A-1 SAR probes (1S,2S)- and (1R,2R)-1, 2-dihydroxy- 1-(2',3'-dihydroxy-4'-methoxyphenyl)-2-(3' ',4' ',5' '-trimethoxyphenyl)-ethane.
Journal of natural products 2000;63(7):969-74.
2000: Z He; Jeffrey L Evelhoch; Ramzi M Mohammad; N Volkan Adsay; George R Pettit; Vainutis K Vaitkevicius; Asfar S Azmi
Magnetic resonance imaging to measure therapeutic response using an orthotopic model of human pancreatic cancer.
Pancreas 2000;21(1):69-76.
2000: George R Pettit; JW Lippert
Antineoplastic agents 429. Syntheses of the combretastatin A-1 and combretastatin B-1 prodrugs.
Anti-cancer drug design 2000;15(3):203-16.
2000: Sanaa M Nabha; Nathan Wall; Ramzi M Mohammad; George R Pettit; Ayad Al-Katib
Effects of combretastatin A-4 prodrug against a panel of malignant human B-lymphoid cell lines.
Anti-cancer drugs 2000;11(5):385-92.
2000: George R Pettit; John C Knight; J C Collins; Delbert L Herald; Robin K Pettit; Michael R Boyd; V G Young
Antineoplastic agents 430. Isolation and structure of cribrostatins 3, 4, and 5 from the republic of maldives cribrochalina species.
Journal of natural products 2000;63(6):793-8.
2000: S B Idso; B A Kimball; G R Pettit Iii; George R Pettit; L C Garner; R A Backhaus
Effects of atmospheric CO2 enrichment on the growth and development of Hymenocallis littoralis (Amaryllidaceae) and the concentrations of several antineoplastic and antiviral constituents of its bulbs.
American journal of botany 2000;87(6):769-73.
2000: John A Beutler; K L McCall; K Herbert; D L Herald; George R Pettit; T Johnson; Robert H Shoemaker; Michael R Boyd
Novel cytotoxic diterpenes from Casearia arborea.
Journal of natural products 2000;63(5):657-61.
2000: Patricia S Lorenzo; M Beheshti; George R Pettit; James C Stone; Peter M Blumberg
The guanine nucleotide exchange factor RasGRP is a high -affinity target for diacylglycerol and phorbol esters.
Molecular pharmacology 2000;57(5):840-6.
2000: Konstantina Grosios; Paul M Loadman; David J Swaine; George R Pettit; Michael C Bibby
Combination chemotherapy with combretastatin A-4 phosphate and 5-fluorouracil in an experimental murine colon adenocarcinoma.
Anticancer research 2000;20(1A):229-33.
2000: L Meijer; A M Thunnissen; A W White; M Garnier; M Nikolic; Li-Huei Tsai; J Walter; Karen E Cleverley; Patricia C Salinas; Y Z Wu; J Biernat; Eva-Maria Mandelkow; S H Kim; George R Pettit
Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent.
Chemistry & biology 2000;7(1):51-63.
2000: George R Pettit; Atsushi Numata; Gordon M Cragg; Delbert L Herald; T Takada; Chika Iwamoto; R Riesen; Jean M Schmidt; Dennis L Doubek; A Goswami
Isolation and structures of schleicherastatins 1-7 and schleicheols 1 and 2 from the teak forest medicinal tree Schleichera oleosa.
Journal of natural products 2000;63(1):72-8.
2000: George R Pettit; BE Toki; Jun-Ping Xu; Daniel C Brune
Synthesis of the marine sponge cycloheptapeptide phakellistatin 5(1).
Journal of natural products 2000;63(1):22-8.
2000: P Verdier-Pinard; J A Kepler; George R Pettit; E Hamel
Sustained intracellular retention of dolastatin 10 causes its potent antimitotic activity.
Molecular pharmacology 2000;57(1):180-7.
1999: Patricia S Lorenzo; K Bögi; K M Hughes; M Beheshti; Dipak Bhattacharyya; Susan H Garfield; George R Pettit; Peter M Blumberg
Differential roles of the tandem C1 domains of protein kinase C delta in the biphasic down-regulation induced by bryostatin 1.
Cancer research 1999;59(24):6137-44.
1999: Nathan Wall; Ramzi M Mohammad; Sanaa M Nabha; George R Pettit; Ayad Al-Katib
Modulation of cIAP-1 by novel antitubulin agents when combined with bryostatin 1 results in increased apoptosis in the human early pre-B acute lymphoblastic leukemia cell line Reh.
Biochemical and biophysical research communications 1999;266(1):76-80.
1999: Konstantina Grosios; SE Holwell; A T McGown; George R Pettit; Michael C Bibby
In vivo and in vitro evaluation of combretastatin A-4 and its sodium phosphate prodrug.
British journal of cancer 1999;81(8):1318-27.
1999: Ramzi M Mohammad; Yiwei Li; Anwar N Mohamed; George R Pettit; Volkan Adsay; Vainutis K Vaitkevicius; Ayad Al-Katib; Asfar S Azmi
Clonal preservation of human pancreatic cell line derived from primary pancreatic adenocarcinoma.
Pancreas 1999;19(4):353-61.
1999: L Détivaud; George R Pettit; Laurent Meijer
Characterization of a novel cdk1-related kinase.
European journal of biochemistry / FEBS 1999;264(1):55-66.
1999: Yulia Ovechkina; Robin K Pettit; Zbigniew A Cichacz; George R Pettit; Berl R Oakley
Unusual antimicrotubule activity of the antifungal agent spongistatin 1.
Antimicrobial agents and chemotherapy 1999;43(8):1993-9.
1999: Ramzi M Mohammad; C Limvarapuss; Nathan Wall; Nayera Hamdy; Frances W J Beck; George R Pettit; Ayad Al-Katib
A new tubulin polymerization inhibitor, auristatin PE, induces tumor regression in a human Waldenstrom's macroglobulinemia xenograft model.
International journal of oncology 1999;15(2):367-72.
1999: George R Pettit; Rui Tan; Noeleen Melody; J M Kielty; Robin K Pettit; Delbert L Herald; B E Tucker; L P Mallavia; Dennis L Doubek; Jean M Schmidt
Antineoplastic agents. Part 409: Isolation and structure of montanastatin from a terrestrial actinomycete.
Bioorganic & medicinal chemistry 1999;7(5):895-9.
1999: George R Pettit; BE Toki; Delbert L Herald; Michael R Boyd; Ernest Hamel; Robin K Pettit; Jean-Charles Chapuis
Antineoplastic agents. 410. Asymmetric hydroxylation of trans-combretastatin A-4.
Journal of medicinal chemistry 1999;42(8):1459-65.
1999: Kevin G Pinney; A D Bounds; K M Dingeman; V P Mocharla; George R Pettit; R Bai; E Hamel
A new anti-tubulin agent containing the benzo[b]thiophene ring system.
Bioorganic & medicinal chemistry letters 1999;9(8):1081-6.
1999: George R Pettit; Monte R Rhodes; Rui Tan
Antineoplastic agents. 400. Synthesis of the Indian Ocean marine sponge cyclic heptapeptide phakellistatin 2.
Journal of natural products 1999;62(3):409-14.
1999: S Zhao; James V Moore; ML Waller; Alan T McGown; John A Hadfield; George R Pettit; David Hastings
Positron emission tomography of murine liver metastases and the effects of treatment by combretastatin A-4.
European journal of nuclear medicine 1999;26(3):231-8.
1999: J M Bodily; D J Hoopes; Beverly L Roeder; S G Gilbert; George R Pettit; C L Herald; D N Rollins; Richard A Robison
The inhibitory effects of bryostatin 1 administration on the growth of rabbit papillomas.
Cancer letters 1999;136(1):67-74.
1999: Gregory P Kalemkerian; X Ou; MR Adil; R Rosati; M M Khoulani; Shashi K Madan; George R Pettit
Activity of dolastatin 10 against small-cell lung cancer in vitro and in vivo: induction of apoptosis and bcl-2 modification.
Cancer chemotherapy and pharmacology 1999;43(6):507-15.
1999: David J Chaplin; George R Pettit; Sally A Hill
Anti-vascular approaches to solid tumour therapy: evaluation of combretastatin A4 phosphate.
Anticancer research 1999;19(1A):189-95.
1998: George R Pettit; Monte R Rhodes; Delbert L Herald; David J Chaplin; Michael R L Stratford; Ernest Hamel; Robin K Pettit; Jean-Charles Chapuis; D Oliva
Antineoplastic agents 393. Synthesis of the trans-isomer of combretastatin A-4 prodrug.
Anti-cancer drug design 1998;13(8):981-93.
1998: Robin K Pettit; George R Pettit; K C Hazen
Specific activities of dolastatin 10 and peptide derivatives against Cryptococcus neoformans.
Antimicrobial agents and chemotherapy 1998;42(11):2961-5.
1998: George R Pettit; Rui Tan; Noeleen Melody; Zbigniew A Cichacz; Delbert L Herald; Michael S Hoard; Robin K Pettit; Jean-Charles Chapuis
Antineoplastic agents. 397: Isolation and structure of sesterstatins 4 and 5 from Hyrtios erecta (the Republic of Maldives).
Bioorganic & medicinal chemistry letters 1998;8(16):2093-8.
1998: Yoshiaki Kamano; A Kotake; H Hashima; M Inoue; H Morita; Koichi Takeya; Hideji Itokawa; N Nandachi; T Segawa; A Yukita; K Saitou; M Katsuyama; George R Pettit
Structure-cytotoxic activity relationship for the toad poison bufadienolides.
Bioorganic & medicinal chemistry 1998;6(7):1103-15.
1998: George R Pettit; Rui Tan; J Xu; Y Ichihara; Michael D Williams; Michael R Boyd
Antineoplastic agents. 398. Isolation and structure elucidation of cephalostatins 18 and 19.
Journal of natural products 1998;61(7):955-8.
1998: Paul A Wender; J DeBrabander; P G Harran; J M Jimenez; M F Koehler; Blaise Lippa; C M Park; C Siedenbiedel; George R Pettit
The design, computer modeling, solution structure, and biological evaluation of synthetic analogs of bryostatin 1.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(12):6624-9.
1998: George R Pettit; J K Srirangam; J Barkoczy; Michael D Williams; Michael R Boyd; Ernest Hamel; Robin K Pettit; Fiona Hogan; R Bai; Jean-Charles Chapuis; Shane C McAllister; Jean M Schmidt
Antineoplastic agents 365. Dolastatin 10 SAR probes.
Anti-cancer drug design 1998;13(4):243-77.
1998: P Khan; Alan T McGown; M J Dawson; Gordon C Jayson; J A Prendiville; George R Pettit; Derek Crowther
High-performance liquid chromatographic assay for the novel antitumor drug, bryostatin-1, incorporating a serum extraction technique.
Journal of chromatography. B, Biomedical sciences and applications 1998;709(1):113-7.
1998: George R Pettit; BE Toki; Delbert L Herald; P Verdier-Pinard; Michael R Boyd; Ernest Hamel; Robin K Pettit
Antineoplastic agents. 379. Synthesis of phenstatin phosphate.
Journal of medicinal chemistry 1998;41(10):1688-95.
1998: Ramzi M Mohammad; Mary Varterasian; VP Almatchy; G N Hannoudi; George R Pettit; Ayad Al-Katib
Successful treatment of human chronic lymphocytic leukemia xenografts with combination biological agents auristatin PE and bryostatin 1.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(5):1337-43.
1998: Ayad Al-Katib; Mitchell R Smith; W S Kamanda; George R Pettit; M Hamdan; Anwar N Mohamed; B Chelladurai; Ramzi M Mohammad
Bryostatin 1 down-regulates mdr1 and potentiates vincristine cytotoxicity in diffuse large cell lymphoma xenografts.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(5):1305-14.
1998: George R Pettit; Monte R Rhodes
Antineoplastic agents 389. New syntheses of the combretastatin A-4 prodrug.
Anti-cancer drug design 1998;13(3):183-91.
1998: Ramzi M Mohammad; Ayad Al-Katib; George R Pettit; Vainutis K Vaitkevicius; US Joshi; Volkan Adsay; Adhip N Majumdar; Asfar S Azmi
An orthotopic model of human pancreatic cancer in severe combined immunodeficient mice: potential application for preclinical studies.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(4):887-94.
1998: Amos B Smith; Q Lin; George R Pettit; Jean-Charles Chapuis; Jean M Schmidt
Synthesis and in vitro cancer cell growth inhibitory activity of monocyclic model compounds containing spongistatin triene side-chains.
Bioorganic & medicinal chemistry letters 1998;8(6):567-8.
1998: MA Ali; R Rosati; George R Pettit; Gregory P Kalemkerian
Dolastatin 15 induces apoptosis and BCL-2 phosphorylation in small cell lung cancer cell lines.
Anticancer research 1998;18(2A):1021-6.
1998: T Turner; WH Jackson; George R Pettit; A Wells; Andrew Kraft
Treatment of human prostate cancer cells with dolastatin 10, a peptide isolated from a marine shell-less mollusc.
The Prostate 1998;34(3):175-81.
1998: Ramzi M Mohammad; George R Pettit; VP Almatchy; Nathan Wall; Mary Varterasian; Ayad Al-Katib
Synergistic interaction of selected marine animal anticancer drugs against human diffuse large cell lymphoma.
Anti-cancer drugs 1998;9(2):149-56.
1998: George R Pettit; E J Flahive; Michael R Boyd; R Bai; Ernest Hamel; Robin K Pettit; Jean M Schmidt
Antineoplastic agents 360. Synthesis and cancer cell growth inhibitory studies of dolastatin 15 structural modifications.
Anti-cancer drug design 1998;13(1):47-66.
1998: George R Pettit; A Cichacz; Rui Tan; Michael S Hoard; Noeleen Melody; Robin K Pettit
Antineoplastic agents. 386. Isolation of sesterstatins 1-3 from the marine sponge Hyrtios erecta.
Journal of natural products 1998;61(1):13-6.
1998: Alan T McGown; Gordon C Jayson; George R Pettit; M S Haran; Tim Ward; Derek Crowther
Bryostatin 1-tamoxifen combinations show synergistic effects on the inhibition of growth of P388 cells in vitro.
British journal of cancer 1998;77(2):216-20.
1998: Mary Varterasian; Ramzi M Mohammad; David Eilender; K Hulburd; DH Rodriguez; Pamela Pemberton; J M Pluda; Maria Dan; George R Pettit; Ben D Chen; Ayad Al-Katib
Phase I study of bryostatin 1 in patients with relapsed non-Hodgkin's lymphoma and chronic lymphocytic leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1998;16(1):56-62.
1997: Patricia S Lorenzo; K Bögi; Peter Acs; George R Pettit; Peter M Blumberg
The catalytic domain of protein kinase Cdelta confers protection from down-regulation induced by bryostatin 1.
The Journal of biological chemistry 1997;272(52):33338-43.
1997: S A Matthews; George R Pettit; E Rozengurt
Bryostatin 1 induces biphasic activation of protein kinase D in intact cells.
The Journal of biological chemistry 1997;272(32):20245-50.
1997: George R Pettit; Jun-Ping Xu; Fiona Hogan; Michael D Williams; Dennis L Doubek; Jean M Schmidt; R L Cerny; Michael R Boyd
Isolation and structure of the human cancer cell growth inhibitory cyclodepsipeptide dolastatin 16.
Journal of natural products 1997;60(8):752-4.
1997: G G Dark; Sally A Hill; Vivien E Prise; Gillian M Tozer; George R Pettit; David J Chaplin
Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculature.
Cancer research 1997;57(10):1829-34.
1997: H W Lee; Lucinda Smith; George R Pettit; Jeffrey B Smith
Bryostatin 1 and phorbol ester down-modulate protein kinase C-alpha and -epsilon via the ubiquitin/proteasome pathway in human fibroblasts.
Molecular pharmacology 1997;51(3):439-47.
1997: George R Pettit; James McNulty; Delbert L Herald; Dennis L Doubek; Jean-Charles Chapuis; Jean M Schmidt; Larry P Tackett; Michael R Boyd
Antineoplastic agents. 362. Isolation and X-ray crystal structure of dibromophakellstatin from the Indian ocean sponge Phakellia mauritiana.
Journal of natural products 1997;60(2):180-3.
1997: Robin K Pettit; Shane C McAllister; George R Pettit; C L Herald; J M Johnson; Zbigniew A Cichacz
A broad-spectrum antifungal from the marine sponge Hyrtios erecta.
International journal of antimicrobial agents 1997;9(3):147-52.
1997: George R Pettit
The dolastatins.
Fortschritte der Chemie organischer Naturstoffe = Progress in the chemistry of organic natural products. Progrès dans la chimie des substances organiques naturelles 1997;70():1-79.
1996: George R Pettit; M S Butler; Michael D Williams; M J Filiatrault; Robin K Pettit
Isolation and structure of hemibastadinols 1-3 from the Papua New Guinea marine sponge Ianthella basta.
Journal of natural products 1996;59(10):927-34.
1996: Ruoli Bai; R E Schwartz; J A Kepler; George R Pettit; E Hamel
Characterization of the interaction of cryptophycin 1 with tubulin: binding in the Vinca domain, competitive inhibition of dolastatin 10 binding, and an unusual aggregation reaction.
Cancer research 1996;56(19):4398-406.
1996: J A McBain; Alan Eastman; D L Simmons; George R Pettit; G C Mueller
Phorbol ester augments butyrate-induced apoptosis of colon cancer cells.
International journal of cancer. Journal international du cancer 1996;67(5):715-23.
1996: H W Lee; L Smith; George R Pettit; A Vinitsky; J B Smith
Ubiquitination of protein kinase C-alpha and degradation by the proteasome.
The Journal of biological chemistry 1996;271(35):20973-6.
1996: George R Pettit; M S Hoard; Dennis L Doubek; Jean M Schmidt; Robin K Pettit; L P Tackett; Jean-Charles Chapuis
Antineoplastic agents 338. The cancer cell growth inhibitory. Constituents of Terminalia arjuna (Combretaceae).
Journal of ethnopharmacology 1996;53(2):57-63.
1996: George R Pettit
Progress in the discovery of biosynthetic anticancer drugs.
Journal of natural products 1996;59(8):812-21.
1996: David J Chaplin; George R Pettit; Charles S Parkins; Sally A Hill
Antivascular approaches to solid tumour therapy: evaluation of tubulin binding agents.
The British journal of cancer. Supplement 1996;27():S86-8.
1996: H W Lee; L Smith; George R Pettit; J Bingham Smith
Dephosphorylation of activated protein kinase C contributes to downregulation by bryostatin.
The American journal of physiology 1996;271(1 Pt 1):C304-11.
1996: J O Carey; K J Posekany; J E deVente; George R Pettit; D K Ways
Phorbol ester-stimulated phosphorylation of PU.1: association with leukemic cell growth inhibition.
Blood 1996;87(10):4316-24.
1996: A Maki; Ramzi M Mohammad; S Raza; M Saleh; K D Govindaraju; George R Pettit; Ayad Al-Katib
Effect of dolastatin 10 on human non-Hodgkin's lymphoma cell lines.
Anti-cancer drugs 1996;7(3):344-50.
1996: Z Szallasi; L Du; R Levine; Nancy E Lewin; P N Nguyen; M D Williams; George R Pettit; Peter M Blumberg
The bryostatins inhibit growth of B16/F10 melanoma cells in vitro through a protein kinase C-independent mechanism: dissociation of activities using 26-epi-bryostatin 1.
Cancer research 1996;56(9):2105-11.
1996: Oystein Fodstad; K Breistøl; George R Pettit; R H Shoemaker; M R Boyd
Comparative antitumor activities of halichondrins and vinblastine against human tumor xenografts.
Journal of experimental therapeutics & oncology 1996;1(2):119-25.
1996: George R Pettit; F Gao; P M Blumberg; C L Herald; J C Coll; Y Kamano; N E Lewin; Jean M Schmidt; Jean-Charles Chapuis
Antineoplastic agents. 340. Isolation and structural elucidation of bryostatins 16-18.
Journal of natural products 1996;59(3):286-9.
1996: X Zhang; Ruiwen Zhang; H Zhao; H Cai; K A Gush; Russell G Kerr; George R Pettit; Andrew Kraft
Preclinical pharmacology of the natural product anticancer agent bryostatin 1, an activator of protein kinase C.
Cancer research 1996;56(4):802-8.
1996: Ramzi M Mohammad; A Maki; George R Pettit; Ayad Al-Katib
Bryostatin 1 induces ubiquitin COOH-terminal hydrolase in acute lymphoblastic leukemia cells.
Enzyme & protein 1996;49(5-6):262-72.
1996: Robert T Dorr; Katerina Dvorakova; K Snead; D S Alberts; Sydney E Salmon; George R Pettit
Antitumor activity of combretastatin-A4 phosphate, a natural product tubulin inhibitor.
Investigational new drugs 1996;14(2):131-7.
1996: G Wynne Aherne; Anthea Hardcastle; M Valenti; A Bryant; P Rogers; George R Pettit; J K Srirangam; Lloyd R Kelland
Antitumour evaluation of dolastatins 10 and 15 and their measurement in plasma by radioimmunoassay.
Cancer chemotherapy and pharmacology 1996;38(3):225-32.
1996: Andrew Kraft; S Woodley; George R Pettit; F Gao; J C Coll; F Wagner
Comparison of the antitumor activity of bryostatins 1, 5, and 8.
Cancer chemotherapy and pharmacology 1996;37(3):271-8.
1995: Y Kamano; H P Zhang; A Hino; M Yoshida; George R Pettit; C L Herald; Hideji Itokawa
An improved source of bryostatin 10, Bugula neritina from the Gulf of Aomori, Japan.
Journal of natural products 1995;58(12):1868-75.
1995: George R Pettit; J K Srirangam; J Barkoczy; Michael D Williams; K P Durkin; Michael R Boyd; Ruoli Bai; E Hamel; Jean M Schmidt; Jean-Charles Chapuis
Antineoplastic agents 337. Synthesis of dolastatin 10 structural modifications.
Anti-cancer drug design 1995;10(7):529-44.
1995: Ramzi M Mohammad; H Diwakaran; A Maki; M A Emara; George R Pettit; Bruce G Redman; Ayad Al-Katib
Bryostatin 1 induces apoptosis and augments inhibitory effects of vincristine in human diffuse large cell lymphoma.
Leukemia research 1995;19(9):667-73.
1995: Ruoli Bai; G F Taylor; Zbigniew A Cichacz; C L Herald; J A Kepler; George R Pettit; E Hamel
The spongistatins, potently cytotoxic inhibitors of tubulin polymerization, bind in a distinct region of the vinca domain.
Biochemistry 1995;34(30):9714-21.
1995: George R Pettit; C Temple; V L Narayanan; R Varma; M J Simpson; Michael R Boyd; G A Rener; N Bansal
Antineoplastic agents 322. synthesis of combretastatin A-4 prodrugs.
Anti-cancer drug design 1995;10(4):299-309.
1995: George R Pettit; Rui Tan; Y Ichihara; Michael D Williams; Dennis L Doubek; L P Tackett; Jean M Schmidt; R L Cerny; Michael R Boyd; J N Hooper
Antineoplastic agents, 325. Isolation and structure of the human cancer cell growth inhibitory cyclic octapeptides phakellistatin 10 and 11 from Phakellia sp.
Journal of natural products 1995;58(6):961-5.
1995: A Maki; H Diwakaran; Bruce G Redman; S al-Asfar; George R Pettit; Ramzi M Mohammad; Ayad Al-Katib
The bcl-2 and p53 oncoproteins can be modulated by bryostatin 1 and dolastatins in human diffuse large cell lymphoma.
Anti-cancer drugs 1995;6(3):392-7.
1995: George R Pettit; S B Singh; Michael R Boyd; E Hamel; Robin K Pettit; Jean M Schmidt; Fiona Hogan
Antineoplastic agents. 291. Isolation and synthesis of combretastatins A-4, A-5, and A-6(1a)
Journal of medicinal chemistry 1995;38(10):1666-72.
1995: Ruoli Bai; G F Taylor; Jean M Schmidt; M D Williams; J A Kepler; George R Pettit; E Hamel
Interaction of dolastatin 10 with tubulin: induction of aggregation and binding and dissociation reactions.
Molecular pharmacology 1995;47(5):965-76.
1995: George R Pettit; G R Pettit; G Groszek; Ralph Backhaus; Dennis L Doubek; R J Barr; A W Meerow
Antineoplastic agents, 301. An investigation of the Amaryllidaceae genus Hymenocallis.
Journal of natural products 1995;58(5):756-9.
1995: George R Pettit; M S Butler; C G Bass; Dennis L Doubek; Michael D Williams; Jean M Schmidt; Robin K Pettit; J N Hooper; L P Tackett; M J Filiatrault
Antineoplastic agents, 326. The stereochemistry of bastadins 8, 10, and 12 from the Bismarck archipelago marine sponge Ianthella basta.
Journal of natural products 1995;58(5):680-8.
1995: George R Pettit; S Freeman; M J Simpson; M A Thompson; Michael R Boyd; Michael D Williams; G R Pettit; Dennis L Doubek
Antineoplastic agents 320: synthesis of a practical pancratistatin prodrug.
Anti-cancer drug design 1995;10(3):243-50.
1995: J A Woods; John A Hadfield; George R Pettit; B W Fox; Alan T McGown
The interaction with tubulin of a series of stilbenes based on combretastatin A-4.
British journal of cancer 1995;71(4):705-11.
1995: V Patella; Vincenzo Casolaro; Antonio Ciccarelli; George R Pettit; M Columbo; Gianni Marone
The antineoplastic bryostatins affect human basophils and mast cells differently.
Blood 1995;85(5):1272-81.
1995: George R Pettit; G R Pettit; Ralph Backhaus; F E Boettner
Antineoplastic agents, 294. Variations in the formation of pancratistatin and related isocarbostyrils in Hymenocallis littoralis.
Journal of natural products 1995;58(1):37-43.
1994: Z Szallasi; Mitchell F Denning; C B Smith; Andrzej Dlugosz; Stuart H Yuspa; George R Pettit; Peter M Blumberg
Bryostatin 1 protects protein kinase C-delta from down-regulation in mouse keratinocytes in parallel with its inhibition of phorbol ester-induced differentiation.
Molecular pharmacology 1994;46(5):840-50.
1994: C Scheid; J Prendiville; Gordon C Jayson; Derek Crowther; B Fox; George R Pettit; Peter L Stern
Immunomodulation in patients receiving intravenous Bryostatin 1 in a phase I clinical study: comparison with effects of Bryostatin 1 on lymphocyte function in vitro.
Cancer immunology, immunotherapy : CII 1994;39(4):223-30.
1994: J Prendiville; Alan T McGown; Andreas J Gescher; A J Dickson; Carol Courage; George R Pettit; Derek Crowther; B W Fox
Establishment of a murine leukaemia cell line resistant to the growth-inhibitory effect of bryostatin 1.
British journal of cancer 1994;70(4):573-8.
1994: Marcelo G Kazanietz; Nancy E Lewin; F Gao; George R Pettit; Peter M Blumberg
Binding of [26-3H]bryostatin 1 and analogs to calcium-dependent and calcium-independent protein kinase C isozymes.
Molecular pharmacology 1994;46(2):374-9.
1994: George R Pettit; F Gao; R L Cerny; Dennis L Doubek; L P Tackett; Jean M Schmidt; Jean-Charles Chapuis
Antineoplastic agents. 278. Isolation and structure of axinastatins 2 and 3 from a western Caroline Island marine sponge.
Journal of medicinal chemistry 1994;37(8):1165-8.
1994: Marcelo G Kazanietz; X R Bustelo; M Barbacid; Walter Kolch; Mischak Harald; G Wong; George R Pettit; J D Bruns; Peter M Blumberg
Zinc finger domains and phorbol ester pharmacophore. Analysis of binding to mutated form of protein kinase C zeta and the vav and c-raf proto-oncogene products.
The Journal of biological chemistry 1994;269(15):11590-4.
1994: W David Jarvis; Lawrence F Povirk; A J Turner; R S Traylor; David Gewirtz; George R Pettit; Steven Grant
Effects of bryostatin 1 and other pharmacological activators of protein kinase C on 1-[beta-D-arabinofuranosyl]cytosine-induced apoptosis in HL-60 human promyelocytic leukemia cells.
Biochemical pharmacology 1994;47(5):839-52.
1994: C Stanwell; A Gescher; T D Bradshaw; George R Pettit
The role of protein kinase C isoenzymes in the growth inhibition caused by bryostatin 1 in human A549 lung and MCF-7 breast carcinoma cells.
International journal of cancer. Journal international du cancer 1994;56(4):585-92.
1994: Steven Grant; R Traylor; George R Pettit; P S Lin
The macrocyclic lactone protein kinase C activator, bryostatin 1, either alone, or in conjunction with recombinant murine granulocyte-macrophage colony-stimulating factor, protects Balb/c and C3H/HeN mice from the lethal in vivo effects of ionizing radiation.
Blood 1994;83(3):663-7.
1994: Z Szallasi; C B Smith; George R Pettit; Peter M Blumberg
Differential regulation of protein kinase C isozymes by bryostatin 1 and phorbol 12-myristate 13-acetate in NIH 3T3 fibroblasts.
The Journal of biological chemistry 1994;269(3):2118-24.
1994: Ramzi M Mohammad; Ayad Al-Katib; George R Pettit; L L Sensenbrenner
Successful treatment of human Waldenström's macroglobulinemia with combination biological and chemotherapy agents.
Cancer research 1994;54(1):165-8.
1994: George R Pettit; J P Xu; Michael D Williams; N D Christie; Dennis L Doubek; Jean M Schmidt; Michael R Boyd
Isolation and structure of cephalostatins 10 and 11.
Journal of natural products 1994;57(1):52-63.
1993: Philip A Philip; D Rea; P Thavasu; J Carmichael; N S Stuart; H Rockett; Denis C Talbot; Trivadi Ganesan; George R Pettit; F Balkwill
Phase I study of bryostatin 1: assessment of interleukin 6 and tumor necrosis factor alpha induction in vivo. The Cancer Research Campaign Phase I Committee.
Journal of the National Cancer Institute 1993;85(22):1812-8.
1993: George R Pettit; D Kantoci; Dennis L Doubek; B E Tucker; W E Pettit; R M Schroll
Isolation of the nickel-chlorin chelate tunichlorin from the South Pacific ocean sea hare Dolabella auricularia.
Journal of natural products 1993;56(11):1981-4.
1993: George R Pettit; G R Pettit; Ralph Backhaus; Michael R Boyd; A W Meerow
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
Journal of natural products 1993;56(10):1682-7.
1993: Ruoli Bai; Zbigniew A Cichacz; C L Herald; George R Pettit; E Hamel
Spongistatin 1, a highly cytotoxic, sponge-derived, marine natural product that inhibits mitosis, microtubule assembly, and the binding of vinblastine to tubulin.
Molecular pharmacology 1993;44(4):757-66.
1993: Steven Grant; R Traylor; George R Pettit; P S Lin
Modulation by bryostatin 1 of the in vitro radioprotective effects of the GM-CSF/IL-3 fusion protein, PIXY 321, on normal human myeloid progenitors.
Cytokine 1993;5(5):490-7.
1993: Ayad Al-Katib; Ramzi M Mohammad; K Khan; M E Dan; George R Pettit; L L Sensenbrenner
Bryostatin 1-induced modulation of the acute lymphoblastic leukemia cell line Reh.
Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy 1993;14(1):33-42.
1993: C W McCrady; F Li; George R Pettit; Steven Grant
Modulation of the activity of a human granulocyte-macrophage colony-stimulating factor/interleukin-3 fusion protein (pIXY 321) by the macrocyclic lactone protein kinase C activator bryostatin 1.
Experimental hematology 1993;21(7):893-900.
1993: R L Berkow; L Schlabach; R Dodson; W H Benjamin; George R Pettit; P Rustagi; Andrew Kraft
In vivo administration of the anticancer agent bryostatin 1 activates platelets and neutrophils and modulates protein kinase C activity.
Cancer research 1993;53(12):2810-5.
1993: Ruoli Bai; M C Roach; S K Jayaram; J Barkoczy; George R Pettit; Richard Luduena; E Hamel
Differential effects of active isomers, segments, and analogs of dolastatin 10 on ligand interactions with tubulin. Correlation with cytotoxicity.
Biochemical pharmacology 1993;45(7):1503-15.
1993: Z B Hu; S M Gignac; Hilmar Quentmeier; George R Pettit; Hans G Drexler
Effects of dolastatins on human B-lymphocytic leukemia cell lines.
Leukemia research 1993;17(4):333-9.
1993: Noah Isakov; D Galron; T Mustelin; George R Pettit; Amnon Altman
Inhibition of phorbol ester-induced T cell proliferation by bryostatin is associated with rapid degradation of protein kinase C.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(4):1195-204.
1993: George R Pettit; Zbigniew A Cichacz; J Barkoczy; A C Dorsaz; Delbert L Herald; Michael D Williams; Dennis L Doubek; Jean M Schmidt; L P Tackett; D C Brune
Isolation and structure of the marine sponge cell growth inhibitory cyclic peptide phakellistatin 1.
Journal of natural products 1993;56(2):260-7.
1993: A A el-Zayat; D Degen; S Drabek; G M Clark; George R Pettit; Daniel Von Hoff
In vitro evaluation of the antineoplastic activity of combretastatin A-4, a natural product from Combretum caffrum (arid shrub).
Anti-cancer drugs 1993;4(1):19-25.
1993: Richard Luduena; M C Roach; V Prasad; George R Pettit
Interaction of halichondrin B and homohalichondrin B with bovine brain tubulin.
Biochemical pharmacology 1993;45(2):421-7.
1993: Ramzi M Mohammad; Ayad Al-Katib; George R Pettit; L L Sensenbrenner
Differential effects of bryostatin 1 on human non-Hodgkin's B-lymphoma cell lines.
Leukemia research 1993;17(1):1-8.
1993: James P Stewart; Alan T McGown; J Prendiville; George R Pettit; B W Fox; John R Arrand
Bryostatin 1 induces productive Epstein-Barr virus replication in latently infected cells: implications for use in immunocompromised patients.
Cancer chemotherapy and pharmacology 1993;33(1):89-91.
1993: Ayad Al-Katib; Ramzi M Mohammad; M Dan; M E Hussein; A Akhtar; George R Pettit; L L Sensenbrenner
Bryostatin 1-induced hairy cell features on chronic lymphocytic leukemia cells in vitro.
Experimental hematology 1993;21(1):61-5.
1992: Steven Grant; W David Jarvis; Paul Steven Swerdlow; A J Turner; R S Traylor; H J Wallace; P S Lin; George R Pettit; David Gewirtz
Potentiation of the activity of 1-beta-D-arabinofuranosylcytosine by the protein kinase C activator bryostatin 1 in HL-60 cells: association with enhanced fragmentation of mature DNA.
Cancer research 1992;52(22):6270-8.
1992: F Li; Steven Grant; George R Pettit; C W McCrady
Bryostatin 1 modulates the proliferation and lineage commitment of human myeloid progenitor cells exposed to recombinant interleukin-3 and recombinant granulocyte-macrophage colony-stimulating factor.
Blood 1992;80(10):2495-502.
1992: Steven Grant; W David Jarvis; A J Turner; H J Wallace; George R Pettit
Effects of bryostatin 1 and rGM-CSF on the metabolism of 1-beta-D-arabinofuranosylcytosine in human leukaemic myeloblasts.
British journal of haematology 1992;82(3):522-8.
1992: B Gabrielsen; T P Monath; J W Huggins; D F Kefauver; George R Pettit; G Groszek; Melinda G Hollingshead; J J Kirsi; W M Shannon; E M Schubert
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
Journal of natural products 1992;55(11):1569-81.
1992: Klaus G Steube; D Grunicke; T Pietsch; S M Gignac; George R Pettit; Hans G Drexler
Dolastatin 10 and dolastatin 15: effects of two natural peptides on growth and differentiation of leukemia cells.
Leukemia 1992;6(10):1048-53.
1992: C J Kane; R Long; W E Petitt; G L Breneman; George R Pettit
Structure of bis(2-chloroethyl)ammonium hexachlorostannate.
Acta crystallographica. Section C, Crystal structure communications 1992;48 ( Pt 8)():1490-1.
1992: Dianne Watters; J Michael; J E Hemphill; S E Hamilton; Martin F Lavin; George R Pettit
Bistratene A: a novel compound causing changes in protein phosphorylation patterns in human leukemia cells.
Journal of cellular biochemistry 1992;49(4):417-24.
1992: Ruoli Bai; S J Friedman; George R Pettit; E Hamel
Dolastatin 15, a potent antimitotic depsipeptide derived from Dolabella auricularia. Interaction with tubulin and effects of cellular microtubules.
Biochemical pharmacology 1992;43(12):2637-45.
1992: T M Tuttle; K P Bethke; Thomas Inge; C W McCrady; George R Pettit; Harry D Bear
Bryostatin 1-activated T cells can traffic and mediate tumor regression.
The Journal of surgical research 1992;52(6):543-8.
1992: Nancy E Lewin; M L Dell'Aquila; George R Pettit; Peter M Blumberg; B S Warren
Binding of [3H]bryostatin 4 to protein kinase C.
Biochemical pharmacology 1992;43(9):2007-14.
1992: Steven Grant; R Traylor; Kapil N Bhalla; C McCrady; George R Pettit
Effect of a combined exposure to cytosine arabinoside, bryostatin 1, and recombinant granulocyte-macrophage colony-stimulating factor on the clonogenic growth in vitro of normal and leukemic human hematopoietic progenitor cells.
Leukemia 1992;6(5):432-9.
1992: T D Bradshaw; A Gescher; George R Pettit
Modulation by staurosporine of phorbol-ester-induced effects on growth and protein kinase C localization in A549 human lung-carcinoma cells.
International journal of cancer. Journal international du cancer 1992;51(1):144-8.
1992: Andrew Kraft; V Adler; P Hall; George R Pettit; W H Benjamin; D E Briles
In vivo administration of bryostatin 1, a protein kinase C activator, decreases murine resistance to Salmonella typhimurium.
Cancer research 1992;52(8):2143-7.
1992: George R Pettit; D Sengupta; P M Blumberg; N E Lewin; Jean M Schmidt; Andrew Kraft
Structural modifications of bryostatin 2.
Anti-cancer drug design 1992;7(2):101-14.
1992: Richard Luduena; M C Roach; V Prasad; George R Pettit
Interaction of dolastatin 10 with bovine brain tubulin.
Biochemical pharmacology 1992;43(3):539-43.
1992: T M Tuttle; Thomas Inge; K P Bethke; C W McCrady; George R Pettit; Harry D Bear
Activation and growth of murine tumor-specific T-cells which have in vivo activity with bryostatin 1.
Cancer research 1992;52(3):548-53.
1992: S Grant; George R Pettit; C McCrady
Effect of bryostatin 1 on the in vitro radioprotective capacity of recombinant granulocyte-macrophage colony-stimulating factor (rGM-CSF) toward committed human myeloid progenitor cells (CFU-GM).
Experimental hematology 1992;20(1):34-42.
1991: George R Pettit; C L Herald; Michael R Boyd; J E Leet; C Dufresne; Dennis L Doubek; Jean M Schmidt; R L Cerny; J N Hooper; K C Rützler
Isolation and structure of the cell growth inhibitory constituents from the western Pacific marine sponge Axinella sp.
Journal of medicinal chemistry 1991;34(11):3339-40.
1991: George R Pettit; Dennis L Doubek; Delbert L Herald; Atsushi Numata; C Takahasi; R Fujiki; T Miyamoto
Isolation and structure of cytostatic steroidal saponins from the African medicinal plant Balanites aegyptica.
Journal of natural products 1991;54(6):1491-502.
1991: Ruoli Bai; KD Paull; C L Herald; L Malspeis; George R Pettit; E Hamel
Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data.
The Journal of biological chemistry 1991;266(24):15882-9.
1991: Steven Grant; L Boise; E Westin; C Howe; George R Pettit; A Turner; C McCrady
In vitro effects of bryostatin 1 on the metabolism and cytotoxicity of 1-beta-D-arabinofuranosylcytosine in human leukemia cells.
Biochemical pharmacology 1991;42(4):853-67.
1991: E A Mackanos; George R Pettit; John S Ramsdell
Bryostatins selectively regulate protein kinase C-mediated effects on GH4 cell proliferation.
The Journal of biological chemistry 1991;266(17):11205-12.
1991: Z Kiss; U R Rapp; George R Pettit; Wayne B Anderson
Phorbol ester and bryostatin differentially regulate the hydrolysis of phosphatidylethanolamine in Ha-ras- and raf-oncogene-transformed NIH 3T3 cells.
The Biochemical journal 1991;276 ( Pt 2)():505-9.
1991: Steven Grant; George R Pettit; C Howe; C McCrady
Effect of the protein kinase C activating agent bryostatin 1 on the clonogenic response of leukemic blast progenitors to recombinant granulocyte-macrophage colony-stimulating factor.
Leukemia 1991;5(5):392-8.
1991: Michael Lilly; C Brown; George R Pettit; Andrew Kraft
Bryostatin 1: a potential anti-leukemic agent for chronic myelomonocytic leukemia.
Leukemia 1991;5(4):283-7.
1991: T D Bradshaw; A Gescher; George R Pettit
The effect of fetal calf serum on growth arrest caused by activators of protein kinase C.
International journal of cancer. Journal international du cancer 1991;47(6):929-32.
1991: N E Lewin; George R Pettit; Y Kamano; Peter M Blumberg
Binding of [26-3H]-epi-bryostatin 4 to protein kinase C.
Cancer communications 1991;3(3):67-70.
1991: Leonard A Zwelling; D Chan; E Altschuler; J Mayes; J Hinds; George R Pettit
Effect of bryostatin 1 on drug-induced, topoisomerase II-mediated DNA cleavage and topoisomerase II gene expression in human leukemia cells.
Biochemical pharmacology 1991;41(5):829-32.
1991: L M Schuchter; A H Esa; S May; M K Laulis; George R Pettit; Allan Hess
Successful treatment of murine melanoma with bryostatin 1.
Cancer research 1991;51(2):682-7.
1991: C W McCrady; Joan G Staniswalis; George R Pettit; C Howe; Steven Grant
Effect of pharmacologic manipulation of protein kinase C by phorbol dibutyrate and bryostatin 1 on the clonogenic response of human granulocyte-macrophage progenitors to recombinant GM-CSF.
British journal of haematology 1991;77(1):5-15.
1991: Z Kiss; J Chattopadhyay; George R Pettit
Stimulation of phosphatidylcholine synthesis by activators of protein kinase C is dissociable from increased phospholipid hydrolysis.
The Biochemical journal 1991;273(Pt 1)():189-94.
1991: George R Pettit
The bryostatins.
Fortschritte der Chemie organischer Naturstoffe = Progress in the chemistry of organic natural products. Progrès dans la chimie des substances organiques naturelles 1991;57():153-195.
1990: George R Pettit; S B Singh; Fiona Hogan; D D Burkett
Chiral modifications of dolastatin 10: the potent cytostatic peptide (19aR)-isodolastatin 10.
Journal of medicinal chemistry 1990;33(12):3132-3.
1990: George R Pettit; Daniel Edwin Schaufelberger; R A Nieman; C Dufresne; J A Saenz-Renauld
Antineoplastic agents, 177. Isolation and structure of phyllanthostatin 6.
Journal of natural products 1990;53(6):1406-13.
1990: Ruoli Bai; George R Pettit; E Hamel
Structure-activity studies with chiral isomers and with segments of the antimitotic marine peptide dolastatin 10.
Biochemical pharmacology 1990;40(8):1859-64.
1990: Ruoli Bai; George R Pettit; E Hamel
Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites.
The Journal of biological chemistry 1990;265(28):17141-9.
1990: A A Tuinman; George R Pettit
Analysis of the amino acid sequence of peptides by mass spectrometry. An ion notation proposal.
International journal of peptide and protein research 1990;36(4):331-4.
1990: Michael Lilly; C Tompkins; C Brown; George R Pettit; Andrew Kraft
Differentiation and growth modulation of chronic myelogenous leukemia cells by bryostatin.
Cancer research 1990;50(17):5520-5.
1990: S B Singh; George R Pettit
Antineoplastic agents, 195. Isolation and structure of aceratioside from Aceratium megalospermum.
Journal of natural products 1990;53(5):1187-92.
1990: Henry Hennings; V A Robinson; D M Michael; George R Pettit; R Jung; Stuart H Yuspa
Development of an in vitro analogue of initiated mouse epidermis to study tumor promoters and antipromoters.
Cancer research 1990;50(15):4794-800.
1990: Ruoli Bai; George R Pettit; E Hamel
Dolastatin 10, a powerful cytostatic peptide derived from a marine animal. Inhibition of tubulin polymerization mediated through the vinca alkaloid binding domain.
Biochemical pharmacology 1990;39(12):1941-9.
1990: A M Jalava; J Heikkilä; G Akerlind; George R Pettit; Karl E O Akerman
Effects of bryostatins 1 and 2 on morphological and functional differentiation of SH-SY5Y human neuroblastoma cells.
Cancer research 1990;50(11):3422-8.
1990: J A McBain; George R Pettit; G C Mueller
Phorbol esters activate proteoglycan metabolism in human colon cancer cells en route to terminal differentiation.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1990;1(6):281-91.
1990: S M Gignac; M Buschie; George R Pettit; A Victor Hoffbrand; H G Drexler
Expression of proto-oncogene c-jun during differentiation of B-chronic lymphocytic leukemia.
Leukemia 1990;4(6):441-4.
1990: R Cirillo; Massimo Triggiani; L Siri; Antonio Ciccarelli; George R Pettit; M Condorelli; Gianni Marone
Cyclosporin A rapidly inhibits mediator release from human basophils presumably by interacting with cyclophilin.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(10):3891-7.
1990: George R Pettit; Atsushi Numata; T Takemura; R H Ode; A S Narula; Jean M Schmidt; G M Cragg; C P Pase
Antineoplastic agents, 107. Isolation of acteoside and isoacteoside from Castilleja linariaefolia.
Journal of natural products 1990;53(2):456-8.
1990: George R Pettit; Delbert L Herald; G M Cragg; J A Rideout; P Brown
Antineoplastic agents, 178. Isolation and structure of lychnostatins 1 and 2 from the South American Lychnophora antillana.
Journal of natural products 1990;53(2):382-90.
1990: Ayad Al-Katib; Ramzi M Mohammad; Anwar N Mohamed; George R Pettit; L L Sensenbrenner
Conversion of high grade lymphoma tumor cell line to intermediate grade with TPA and bryostatin 1 as determined by polypeptide analysis on 2D gel electrophoresis.
Hematological oncology 1990;8(2):81-9.
1990: M Columbo; D Galeone; G Guidi; A Kagey-Sobotka; L M Lichtenstein; George R Pettit; Gianni Marone
Modulation of mediator release from human basophils and pulmonary mast cells and macrophages by auranofin.
Biochemical pharmacology 1990;39(2):285-91.
1990: George R Pettit; G M Cragg; S B Singh; J A Duke; Dennis L Doubek
Antineoplastic agents, 162. Zephyranthes candida.
Journal of natural products 1990;53(1):176-8.
1990: George R Pettit; J A Rideout; J A Hasler
Isolation of geodiatoxins 2-4 from the marine sponge Geodia mesotriaena.
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology 1990;96(2):305-6.
1990: H G Drexler; S M Gignac; George R Pettit; A Victor Hoffbrand
Synergistic action of calcium ionophore A23187 and protein kinase C activator bryostatin 1 on human B cell activation and proliferation.
European journal of immunology 1990;20(1):119-27.
1989: H G Drexler; S M Gignac; R A Jones; C S Scott; George R Pettit; A Victor Hoffbrand
Bryostatin 1 induces differentiation of B-chronic lymphocytic leukemia cells.
Blood 1989;74(5):1747-57.
1989: C M Lin; H H Ho; George R Pettit; E Hamel
Antimitotic natural products combretastatin A-4 and combretastatin A-2: studies on the mechanism of their inhibition of the binding of colchicine to tubulin.
Biochemistry 1989;28(17):6984-91.
1989: Anton M Jetten; M A George; George R Pettit; J I Rearick
Effects of bryostatins and retinoic acid on phorbol ester- and diacylglycerol-induced squamous differentiation in human tracheobronchial epithelial cells.
Cancer research 1989;49(14):3990-5.
1989: Anton M Jetten; M A George; George R Pettit; C L Herald; J I Rearick
Action of phorbol esters, bryostatins, and retinoic acid on cholesterol sulfate synthesis: relation to the multistep process of differentiation in human epidermal keratinocytes.
The Journal of investigative dermatology 1989;93(1):108-15.
1989: I L Dale; T D Bradshaw; A Gescher; George R Pettit
Comparison of effects of bryostatins 1 and 2 and 12-O-tetradecanoylphorbol-13-acetate on protein kinase C activity in A549 human lung carcinoma cells.
Cancer research 1989;49(12):3242-5.
1989: J C Baer; J A Slack; George R Pettit
Stability-indicating high-performance liquid chromatography assay for the anticancer drug bryostatin 1.
Journal of chromatography 1989;467(1):332-5.
1989: Andrew Kraft; F William; George R Pettit; Michael Lilly
Varied differentiation responses of human leukemias to bryostatin 1.
Cancer research 1989;49(5):1287-93.
1989: George R Pettit; S B Singh; E Hamel; C M Lin; D S Alberts; D Garcia-Kendall
Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4.
Experientia 1989;45(2):209-11.
1989: Peter M Blumberg; George R Pettit; B S Warren; Arpad Szallasi; L D Schuman; N A Sharkey; H Nakakuma; M L Dell'Aquila; D J de Vries
The protein kinase C pathway in tumor promotion.
Progress in clinical and biological research 1989;298():201-12.
1988: Allan Hess; M K Silanskis; A H Esa; George R Pettit; W S May
Activation of human T lymphocytes by bryostatin.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(10):3263-9.
1988: J P Leonard; W S May; J N Ihle; George R Pettit; Saul J Sharkis
Regulation of hematopoiesis-IV: The role of interleukin-3 and bryostatin 1 in the growth of erythropoietic progenitors from normal and anemic W/Wv mice.
Blood 1988;72(5):1492-6.
1988: George R Pettit; Daniel Edwin Schaufelberger
Isolation and structure of the cytostatic lignan glycoside phyllanthostatin A.
Journal of natural products 1988;51(6):1104-12.
1988: D J de Vries; C L Herald; George R Pettit; Peter M Blumberg
Demonstration of sub-nanomolar affinity of bryostatin 1 for the phorbol ester receptor in rat brain.
Biochemical pharmacology 1988;37(21):4069-73.
1988: B S Warren; Y Kamano; George R Pettit; Peter M Blumberg
Mimicry of bryostatin 1 induced phosphorylation patterns in HL-60 cells by high-phorbol ester concentrations.
Cancer research 1988;48(21):5984-8.
1988: Paul A Wender; C M Cribbs; Koehler F Konrad; N A Sharkey; C L Herald; Y Kamano; George R Pettit; Peter M Blumberg
Modeling of the bryostatins to the phorbol ester pharmacophore on protein kinase C.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(19):7197-201.
1988: C M Lin; S B Singh; P S Chu; R O Dempcy; Jean M Schmidt; George R Pettit; E Hamel
Interactions of tubulin with potent natural and synthetic analogs of the antimitotic agent combretastatin: a structure-activity study.
Molecular pharmacology 1988;34(2):200-8.
1988: J Parker; M Waite; George R Pettit; L W Daniel
Stimulation of arachidonic acid release and prostaglandin synthesis by bryostatin 1.
Carcinogenesis 1988;9(8):1471-4.
1988: M L Dell'Aquila; C L Herald; Y Kamano; George R Pettit; Peter M Blumberg
Differential effects of bryostatins and phorbol esters on arachidonic acid metabolite release and epidermal growth factor binding in C3H 10T1/2 cells.
Cancer research 1988;48(13):3702-8.
1988: Richard M Stone; E Sariban; George R Pettit; Donald Kufe
Bryostatin 1 activates protein kinase C and induces monocytic differentiation of HL-60 cells.
Blood 1988;72(1):208-13.
1988: A P Fields; George R Pettit; W S May
Phosphorylation of lamin B at the nuclear membrane by activated protein kinase C.
The Journal of biological chemistry 1988;263(17):8253-60.
1988: George R Pettit; S B Singh; Jean M Schmidt; M L Niven; E Hamel; C M Lin
Isolation, structure, synthesis, and antimitotic properties of combretastatins B-3 and B-4 from Combretum caffrum.
Journal of natural products 1988;51(3):517-27.
1988: Michael Gschwendt; Gerhard Fürstenberger; S Rose-John; M Rogers; W Kittstein; George R Pettit; C L Herald; Friedrich Marks
Bryostatin 1, an activator of protein kinase C, mimics as well as inhibits biological effects of the phorbol ester TPA in vivo and in vitro.
Carcinogenesis 1988;9(4):555-62.
1988: G Pasti; E Rivedal; Stuart H Yuspa; C L Herald; George R Pettit; Peter M Blumberg
Contrasting duration of inhibition of cell-cell communication in primary mouse epidermal cells by phorbol 12,13-dibutyrate and by bryostatin 1.
Cancer research 1988;48(2):447-51.
1988: G Trenn; George R Pettit; H Takayama; Jane Hu-Li; Michail V Sitkovsky
Immunomodulating properties of a novel series of protein kinase C activators. The bryostatins.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(2):433-9.
1988: J A McBain; George R Pettit; G C Mueller
Bryostatin 1 antagonizes the terminal differentiating action of 12-O-tetradecanoylphorbol-13-acetate in a human colon cancer cell.
Carcinogenesis 1988;9(1):123-9.
1988: J T Warren; A H Esa; George R Pettit; W S May
Bryostatin stimulation of human neutrophil luminol and DBA (lucigenin) chemiluminescence.
Basic life sciences 1988;49():223-7.
1988: Y Kamano; N Satoh; H Nakayoshi; George R Pettit; C R Smith
Rhinovirus inhibition by bufadienolides.
Chemical & pharmaceutical bulletin 1988;36(1):326-32.
1987: W S May; Saul J Sharkis; A H Esa; V Gebbia; Andrew Kraft; George R Pettit; L L Sensenbrenner
Antineoplastic bryostatins are multipotential stimulators of human hematopoietic progenitor cells.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(23):8483-7.
1987: M L Dell'Aquila; H T Nguyen; C L Herald; George R Pettit; Peter M Blumberg
Inhibition by bryostatin 1 of the phorbol ester-induced blockage of differentiation in hexamethylene bisacetamide-treated Friend erythroleukemia cells.
Cancer research 1987;47(22):6006-9.
1987: Harald Mohr; George R Pettit; A Plessing-Menze
Co-induction of lymphokine synthesis by the antineoplastic bryostatins.
Immunobiology 1987;175(5):420-30.
1987: J C Garrison; George R Pettit; E M Uyeki
Effect of phorbol and bryostatin I on chondrogenic expression of chick limb bud, in vitro.
Life sciences 1987;41(17):2055-61.
1987: T Sako; Stuart H Yuspa; C L Herald; George R Pettit; Peter M Blumberg
Partial parallelism and partial blockade by bryostatin 1 of effects of phorbol ester tumor promoters on primary mouse epidermal cells.
Cancer research 1987;47(20):5445-50.
1987: Henry Hennings; P M Blumberg; George R Pettit; C L Herald; R Shores; Stuart H Yuspa
Bryostatin 1, an activator of protein kinase C, inhibits tumor promotion by phorbol esters in SENCAR mouse skin.
Carcinogenesis 1987;8(9):1343-6.
1987: Z Kiss; E Deli; P R Girard; George R Pettit; J F Kuo
Comparative effects of polymyxin B, phorbol ester and bryostatin on protein phosphorylation, protein kinase C translocation, phospholipid metabolism and differentiation of HL60 cells.
Biochemical and biophysical research communications 1987;146(1):208-15.
1987: George R Pettit; G M Cragg; S B Singh
Antineoplastic agents, 122. Constituents of Combretum caffrum.
Journal of natural products 1987;50(3):386-91.
1987: George R Pettit; G M Cragg; C W Holzapfel; A A Tuinman; D P Gieschen
Solution-phase secondary-ion mass spectrometry of protonated amino acids.
Analytical biochemistry 1987;162(1):236-41.
1987: Z Kiss; E Deli; M Shoji; H P Koeffler; George R Pettit; W R Vogler; J F Kuo
Differential effects of various protein kinase C activators on protein phosphorylation in human acute myeloblastic leukemia cell line KG-1 and its phorbol ester-resistant subline KG-1a.
Cancer research 1987;47(5):1302-7.
1987: George R Pettit; S B Singh; M L Niven; E Hamel; Jean M Schmidt
Isolation, structure, and synthesis of combretastatins A-1 and B-1, potent new inhibitors of microtubule assembly, derived from Combretum caffrum.
Journal of natural products 1987;50(1):119-31.
1986: J S Ramsdell; George R Pettit; A H Tashjian
Three activators of protein kinase C, bryostatins, dioleins, and phorbol esters, show differing specificities of action on GH4 pituitary cells.
The Journal of biological chemistry 1986;261(36):17073-80.
1986: George R Pettit; V Gaddamidi; Delbert L Herald; S B Singh; G M Cragg; Jean M Schmidt; F E Boettner; M Williams; Y Sagawa
Antineoplastic agents, 120. Pancratium littorale.
Journal of natural products 1986;49(6):995-1002.
1986: George R Pettit; Y Kamano; C L Herald
Antineoplastic agents, 118. Isolation and structure of bryostatin 9.
Journal of natural products 1986;49(4):661-4.
1986: George R Pettit; D L Herald; C L Herald; W C Kokke; Carl Djerassi
The crystal structure of 3 beta-hydroxy-4 alpha, 23R, 24R-trimethyl-5 alpha-cholestane (23R, 24R-5 alpha-dinostanol) from dinoflagellates.
Steroids 1986;47(4-5):321-6.
1986: George R Pettit; J E Leet; C L Herald; Y Kamano; Dennis L Doubek
Antineoplastic agents, 116. An evaluation of the marine ascidian Aplidium californicum.
Journal of natural products 1986;49(2):231-5.
1985: J B Smith; L Smith; George R Pettit
Bryostatins: potent, new mitogens that mimic phorbol ester tumor promoters.
Biochemical and biophysical research communications 1985;132(3):939-45.
1985: D M Piatak; J Patel; C E Totten; R P Swenson; P Brown; George R Pettit
Cell growth inhibitory glycosides from Asclepias amplexicaulis.
Journal of natural products 1985;48(3):470-1.
1984: George R Pettit; V Gaddamidi; G M Cragg
Antineoplastic agents, 105. Zephyranthes grandiflora.
Journal of natural products 1984;47(6):1018-20.
1984: George R Pettit; A Goswami; G M Cragg; Jean M Schmidt; J C Zou
Antineoplastic agents, 103. The isolation and structure of hypoestestatins 1 and 2 from the East African Hypoëstes verticillaris.
Journal of natural products 1984;47(6):913-9.
1984: George R Pettit; V Gaddamidi; A Goswami; G M Cragg
Antineoplastic agents, 99. Amaryllis belladonna.
Journal of natural products 1984;47(5):796-801.
1983: George R Pettit; J C Zou; A Goswami; G M Cragg; Jean M Schmidt
Antineoplastic agents, 88. Pimelea prostrata.
Journal of natural products 1983;46(4):563-8.
1983: George R Pettit; Derek Barton; C L Herald; J Polonsky; Jean M Schmidt; J D Connolly
Evaluation of limonoids against the murine P388 lymphocytic leukemia cell line.
Journal of natural products 1983;46(3):379-90.
1982: George R Pettit; Y Fujii; J A Hasler; Jean M Schmidt
Isolation and characterization of palystatins A-D.
Journal of natural products 1982;45(3):272-6.
1981: George R Pettit; J A Hasler; K D Paull; C L Herald
Antineoplastic agents. 76. The sea urchin Strongylocentrotus droebachiensis.
Journal of natural products 1981;44(6):701-4.
1981: George R Pettit; J A Rideout; J A Hasler
Isolation of geodiastatins 1 and 2 from the marine sponge Geodia mesotriaena.
Journal of natural products 1981;44(5):588-92.
1981: George R Pettit; Y Kamano; Y Fujii; C L Herald; M Inoue; P Brown; D Gust; K Kitahara; Jean M Schmidt; Dennis L Doubek; C Michel
Marine animal biosynthetic constituents for cancer chemotherapy.
Journal of natural products 1981;44(4):482-5.
1980: George R Pettit; C L Herald; R H Ode; P Brown; D J Gust; C Michel
The isolation of loliolide from an Indian Ocean opisthobranch mollusc.
Journal of natural products 1980;43(6):752-5.
1980: J Polonsky; Z Varon; C Moretti; George R Pettit; C L Herald; J A Rideout; S B Saha; H N Khastgir
The antineoplastic quassinoids of Simaba cuspidata spruce and Ailanthus grandis Prain.
Journal of natural products 1980;43(4):503-9.
1979: George R Pettit; D P Gieschen; W E Pettit
Antineoplastic agents LXIV: 1,4-Bis(2'-chloroethyl)-1,4-diazabicyclo[2.2.1]heptane dihydrogen dimaleate.
Journal of pharmaceutical sciences 1979;68(12):1539-42.
1979: J Polonsky; Z Varon; C Marazano; B Arnoux; George R Pettit; J M Schmid; M Ochi; H Kotsuki
The structure of amoorastatone and the cytotoxic limonoid 12-hydroxyamoorastatin.
Experientia 1979;35(8):987-9.
1979: George R Pettit; T H Smith
Structural biochemistry XIII: Synthesis of luteinizing hormone-releasing hormone modification [Trp8]-LH-RH.
Journal of pharmaceutical sciences 1979;68(8):1013-5.
1979: George R Pettit; T S Krupa; R M Reynolds
Structural biochemistry. 17. Synthesis of tryptophan dipeptides.
International journal of peptide and protein research 1979;14(3):193-8.
1978: J Polonsky; Z Varon; H Jacquemin; George R Pettit
The isolation and structure of 13,18-dehydroglaucarubinone, a new antineoplastic quassinoid from Simarouba amara.
Experientia 1978;34(9):1122-3.
1978: Jean M Schmidt; George R Pettit
Presence of oncornavirus-like particles in the P388 murine leukemic cell line.
Experientia 1978;34(5):659-60.
1978: George R Pettit; J J Einck; P Brown
Structural biochemistry 15--mass spectrometry of permethylated nucleotides.
Biomedical mass spectrometry 1978;5(2):153-60.
1978: George R Pettit; C L Herald; G F Judd; G Bolliger; L D Vanell; E Lehto; C P Pase
Antineoplastic agents. 52. Baileya multiradiata.
Lloydia 1978;41(1):29-36.
1977: George R Pettit; R M Blazer; D A Reierson
Antineoplastic agents. 51. The yellow jacket Vespula pensylvanica.
Lloydia 1977;40(3):247-52.
1977: George R Pettit; R H Ode
Antineoplastic agents L: isolation and characterization of sphyrnastatins 1 and 2 from the hammerhead shark Sphyrna lewini.
Journal of pharmaceutical sciences 1977;66(5):757-8.
1977: Y Kamano; George R Pettit; M Tozawa; S Yoshida
Steroids and related natural products. 94 Synthesis of toad venom cardenolides.
The Journal of organic chemistry 1977;42(5):906-8.
1977: George R Pettit; C L Herald; M S Allen; R B von Dreele; L D Vanell; J P Kao; W Blake
The isolation and structure of aplysistatin.
Journal of the American Chemical Society 1977;99(1):262-3.
1976: George R Pettit; R B Von Dreele; D L Herald; M T Edgar; H B Wood
Structure of an antineoplastic agent from Streptomyces griseoluteus.
Journal of the American Chemical Society 1976;98(21):6742-3.
1976: George R Pettit; C L Herald; D L Herald
Antineoplastic agents XLV: sea cucumber cytotoxic saponins.
Journal of pharmaceutical sciences 1976;65(10):1558-9.
1976: George R Pettit; R H Ode; R M Coomes; S L Ode
Antineoplastic agents. 42. The butterfly, Prioneris thestylis.
Lloydia 1976;39(5):363-7.
1976: George R Pettit; R H Ode
Antineoplastic agents. 41. The beetle Allomyrina dichotomus.
Lloydia 1976;39(2-3):129-33.
1975: George R Pettit; J J Einck; C L Herald; R H Ode; R B Von Dreele; P Brown; M G Brazhnikova; G F Gause
Letter: The structure of carminomycin I.
Journal of the American Chemical Society 1975;97(25):7387-8.
1975: George R Pettit; C L Herald; G F Judd; G Bolliger; P S Thayer
Antineoplastic and cytotoxic components of desert Baileya.
Journal of pharmaceutical sciences 1975;64(12):2023-4.
1975: R B Von Dreele; George R Pettit; R H Ode; R E Perdue; J D White; P S Manchand
The crystal and molecular structure of the unusual spiro dihydrofuran diterpene nepetaefolin.
Journal of the American Chemical Society 1975;97(21):6236-40.
1975: Y Kamano; George R Pettit; M Tozawa; Y Komeichi; M Inoue
Bufadienolides. 30. Synthesis of the Ch'an Su component 15beta-hydroxybufalin.
The Journal of organic chemistry 1975;40(14):2136-8.
1975: Y Kamano; M Tozawa; George R Pettit
Steroids and related natural products. 90. 15beta-Hydroxydigitoxigenin.
The Journal of organic chemistry 1975;40(6):793-6.
1975: Y Kamano; George R Pettit; M Tozawa
Steroids and related natural products. Part XCII. Conversion of canarigenone (14-hydroxy-3-oxo-14beta-carda-4,20(22)-dienolide) into periplogenin (3beta,5,14-trihydroxy-5beta,14beta-card-20(22)-enolide).
Journal of the Chemical Society. Perkin transactions 1 1975;(19):1976-8.
1975: Y Kamano; George R Pettit; M Tozawa
Steroids and related natural products. Part XCI. Synthesis of the cardenolides canarigenin and uzarigenin.
Journal of the Chemical Society. Perkin transactions 1 1975;(19):1972-6.
1974: Y Kamano; George R Pettit; M Inoue
Bufadienolides. 29. Synthetic routes to bufotalin.
The Journal of organic chemistry 1974;39(20):3007-13.
1974: George R Pettit; Y Kamano
Bufadienolides. 28. Marinobufotoxin.
The Journal of organic chemistry 1974;39(20):3003-6.
1974: George R Pettit; E I Saldana; E Lehto
Antineoplastic agents 35. Rhus trilobata.
Lloydia 1974;37(3):539-40.
1974: George R Pettit; J C Budzinski; G M Cragg; P Brown; L D Johnston
Antineoplastic agents. 34. Helenium autumnale L.
Journal of medicinal chemistry 1974;17(9):1013-6.
1974: George R Pettit; Y Kamano
Bufadienolides. 27. Synthesis of telocinobufagin.
The Journal of organic chemistry 1974;39(17):2632-4.
1974: Y Kamano; George R Pettit
Bufadienolides. 26. Synthesis of scillarenin.
The Journal of organic chemistry 1974;39(17):2629-31.
1974: George R Pettit; E I Saldana
Antineoplastic agents. 36. Acetylenic carrier groups.
Journal of medicinal chemistry 1974;17(8):896-8.
1974: Y Kamano; George R Pettit; M Tozawa
Steroids and related natural products. 88. Synthesis of periplogenin.
The Journal of organic chemistry 1974;39(15):2319-20.
1973: George R Pettit; R H Ode; T B Harvey
Isolation of taurine from the molluscs Macrocallista nimbosa and Turbo stenogyrus.
Lloydia 1973;36(2):204-6.
1973: George R Pettit; P M Traxler; C P Pase
Antineoplastic agents 31. Oenothera caespitosa.
Lloydia 1973;36(2):202-3.
1973: George R Pettit; R B von Dreele; G Bollinger; P M Traxler; P Brown
Isolation and structural elucidation of 3,6-dioxo-hexahydro-pyrrolo (1,2-a)-pyrazine from the echinoderm Luidia clathrata.
Experientia 1973;29(5):521-2.
1973: George R Pettit; Y Kamano
Bufadienolides. 23. 14,15 -Epoxy-3 ,11 -dihydroxy-5 -bufa-20,22-dienolide (11 -hydroxyresibufogenin).
Journal of the Chemical Society. Perkin transactions 1 1973;7():725-7.
1973: George R Pettit; S K Gupta; R H Ode
Structural biochemisry. XII. Synthesis of tobacco mosaic virus protein unit 150-158.
Journal of the Chemical Society. Perkin transactions 1 1973;9():950-4.
1973: George R Pettit; G M Cragg
Antineoplastic agents. 32. The pseudoguaianolide helenalin.
Experientia 1973;29(7):781.
1972: George R Pettit; Y Kamano
Bufadienolides. 21. Synthesis of cinobufagin from bufotalin.
The Journal of organic chemistry 1972;37(25):4040-4.
1972: Y Kamano; George R Pettit
Transformation of digitoxigenin to scillarenin.
Journal of the American Chemical Society 1972;94(24):8592-3.
1972: George R Pettit; R J Quinn; T H Smith; P Brown
The camptothecin -lectone.
The Journal of organic chemistry 1972;37(17):2789-91.
1972: Y Kamano; George R Pettit
Synthesis of marinobufagin and marinobufotoxin from telecinobufagin.
Experientia 1972;28(7):768.
1972: F W Villaescusa; George R Pettit
Steroids and related natural products. 70. Conversion of cardenolides to isocardanolides.
Journal of medicinal chemistry 1972;15(7):781-3.
1972: George R Pettit; L E Houghton; N H Rogers; R M Coomes; D F Berger; P R Reucroft; J F Day; J L Hartwell; H B Wood
Butterfly wing antineoplastic agents.
Experientia 1972;28(4):381-2.
1972: George R Pettit; J R Dias
Steroids and related natural products. 66. Structural modification of the triterpene A ring.
The Journal of organic chemistry 1972;37(7):973-6.
1972: P Brown; F Brüschweiler; George R Pettit
[Mass spectrum studies of natural products; cardenolides].
Helvetica chimica acta 1972;55(2):531-43.
1972: F W Villaescusa; George R Pettit
Steroids and related natural products. 69. Synthesis of 20(22)-dihydro-23-deoxodigitoxigenin.
The Journal of organic chemistry 1972;37(4):569-72.
1971: George R Pettit; Y Kamano; F Bruschweiler; P Brown
Bufadienolides. 14. Synthesis of bufotalien, 15 -hydroxybufalin, and resibufogenin.
The Journal of organic chemistry 1971;36(24):3736-9.
1971: W C Fleming; George R Pettit
Synthesis of 2-dialkylamino-6- and -7-hydroxy-5,8-dioxoquinolines.
The Journal of organic chemistry 1971;36(23):3490-3.
1971: D J Abraham; R D Rosenstein; George R Pettit
Single crystal x-ray structures of chemotherapeutic agents. 3. Structure of 1,4-diazabicyclo[2.2.1]heptanes, a new heterocyclic ring system.
Journal of medicinal chemistry 1971;14(11):1141-2.
1971: George R Pettit; J R Dias
Bufadienolides. 13. Conversion of 3 beta-hydroxy-17-oxoandrost-5-ene to 3 beta-acetoxy-5 beta, 14 alpha-bufa-20,22-dienolide.
The Journal of organic chemistry 1971;36(21):3207-11.
1971: George R Pettit; W R Jones
Synthesis of tobacco mosaic virus protein sequence 81-85.
The Journal of organic chemistry 1971;36(7):870-3.
1970: George R Pettit; T R Kasturi
Steroids and related natural products. 63. 17-beta-acetoxy-4-oxa-2-androstene.
Journal of medicinal chemistry 1970;13(6):1244-5.
1970: George R Pettit; L E Houghton; J C Knight; F Bruschweiler
Bufadienolides. 11. Bufalin and resibufogenin.
The Journal of organic chemistry 1970;35(9):2895-8.
1970: George R Pettit; J F Day; J L Hartwell; H B Wood
Antineoplastic components of marine animals.
Nature 1970;227(5261):962-3.
1970: George R Pettit; T R Kasturi; J C Knight; J Occolowitz
Bufadienolides. 8. 12(13--14)abeo skeletal rearrangements.
The Journal of organic chemistry 1970;35(5):1404-10.
1970: George R Pettit; B Green; G L Dunn; P Sunder-Plassmann
Bufadienolides. 4. Reaction of 20-oxo steroids with methoxymethylenetriphenylphosphorane.
The Journal of organic chemistry 1970;35(5):1385-9.
1970: J C Knight; George R Pettit; P Brown
Bufadienolides. 10. 3-beta-acetoxy-14-beta,21-epoxy-5-beta-bufanolide and related lactones.
The Journal of organic chemistry 1970;35(5):1415-9.
1970: George R Pettit; T R Kasturi; J C Knight; K A Jaeggi
Bufadienolides. 9. Isobufalin.
The Journal of organic chemistry 1970;35(5):1410-4.
1970: George R Pettit; J C Knight; C L Herald
Bufadienolides. 6. Synthesis of 17-beta-(6'-alpha-pyronyl)androstanes.
The Journal of organic chemistry 1970;35(5):1393-8.
1970: George R Pettit; C L Herald; J P Yardley
Bufadienolides. 5. Synthesis of cardenolides.
The Journal of organic chemistry 1970;35(5):1389-92.
1970: George R Pettit; B Green; A K Das Gupta; P A Whitehouse; J P Yardley
Bufadienolides. 3. A synthetic route to isocardenolides.
The Journal of organic chemistry 1970;35(5):1381-4.
1970: George R Pettit; B Green; G L Dunn
Bufadienolides. 2. 20-hydroxy-21-nor-5-alpha-cholanic acid gamma-lactones (24--20).
The Journal of organic chemistry 1970;35(5):1377-80.
1970: George R Pettit; B Green; G L Dunn
Bufadienolides. 1. Introduction and base-catalyzed condensation of methyl ketones with glyoxylic acid.
The Journal of organic chemistry 1970;35(5):1367-76.
1970: George R Pettit; D C Fessler; K D Paull; P Hofer; J C Knight
Bufadienolides. 7. Synthesis of 3-beta-acetoxy-5-alpha,14-alpha-bufa-20,22-dienolide.
The Journal of organic chemistry 1970;35(5):1398-404.
1969: D C Fessler; George R Pettit; J A Settepani
Antineoplastic agents. XXV. 1,4-Diazabicyclo [2.2.1] heptanes.
Journal of medicinal chemistry 1969;12(3):542-3.
1968: George R Pettit; J L Hartwell; H B Wood
Arthropod antineoplastic agent.
Cancer research 1968;28(10):2168-9.
1968: George R Pettit; L E Houghton
Synthesis of 6-hydroxy-5,8-dioxo-7-(9-hydroxy-9'-n-pentyltetradecyl)carbostyril.
Journal of medicinal chemistry 1968;11(5):1080-2.
1968: J C Knight; George R Pettit
Oxidation of 3-beta-acetoxy-14-alpha-methyl-5-alpha-cholest-7-ene.
The Journal of organic chemistry 1968;33(4):1684-6.
1968: George R Pettit; W C Fleming; K D Paull
Synthesis of the 6- and 7-hydroxy-5,8-dioxocarbostyrils.
The Journal of organic chemistry 1968;33(3):1089-92.
1968: George R Pettit; S K Gupta
Structural biochemistry. 8. 9-Amino-(9-deoxy)-cinchona alkaloids.
Journal of the Chemical Society. Perkin transactions 1 1968;10():1208-13.
1967: George R Pettit; S K Gupta; P A Whitehouse
Antineoplastic agents. 18. N-(2-haloethyl)benzylamines.
Journal of medicinal chemistry 1967;10(4):692-6.
1967: George R Pettit; R L Smith; H Klinger
Synthesis of 3-beta-acetoxy-17-beta-(L-arginyl-L-arginyl-L-prolyl) amino-5-alpha-androstane.
Journal of medicinal chemistry 1967;10(2):145-8.
1967: George R Pettit; T H Brown
Steroids and related natural products. XLI. 14 alpha-Methyl Oestranes.
Journal of the Chemical Society. Perkin transactions 1 1967;20():2024-6.
1967: J C Knight; J L Belletire; George R Pettit
Steroids and related natural products. XLII. 14-alpha-methyl cholestanes.
Journal of the Chemical Society. Perkin transactions 1 1967;22():2427-32.
1966: George R Pettit; J P Yardley
Cardenolides.
Chemistry & industry 1966;13():553.
1964: George R Pettit; A K Das Gupta; H Klinger; J Occolowitz
Steroidal peptides.
Experientia 1964;20(10):545-6.
1964: George R Pettit; B Green; A K Das Gupta; G L Dunn
Isocardenolides.
Experientia 1964;20(5):248-9.
1963: George R Pettit
Steroid stereochemistry.
Experientia 1963;19():124-5.
1962: G P MUELLER; George R Pettit
Nomenclature of steroidal sapogenins.
Experientia 1962;18():404-5.
1962: George R Pettit; M F BAUMANN; K N RANGAMMAL
ANTINEOPLASTIC AGENTS. V. THE AROMATIC SYSTEM OF PODOPHYLLOTOXIN (PART B).
Journal of medicinal and pharmaceutical chemistry 1962;91():800-8.
1962: George R Pettit; J A SETTEPANI
ANTINEOPLASTIC AGENTS. IV. MANNICH BASE NITROGEN MUSTARDS (PART A).
Journal of medicinal and pharmaceutical chemistry 1962;5():296-302.