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George Pettit

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
55
Pettit, Robin
43
Schmidt, Jean
40
Herald, Delbert
37
Doubek, Dennis
29
Chapuis, Jean-Charles
26
Boyd, Michael
22
Blumberg, Peter
22
Mohammad, Ramzi
20
Knight, John
20
Al-Katib, Ayad
18
Hamel, Ernest
18
Tan, Rui
16
Williams, Michael
16
Bai, Ruoli
13
Melody, Noeleen

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Publications

TOP 3
Pettit George R; Melody Noeleen; Thornhill Andrew; Knight John C; Groy Thomas L; Herald Cherry L
Antineoplastic agents. 579. Synthesis and cancer cell growth evaluation of E-stilstatin 3: a resveratrol structural modification.
Pettit Robin K; Pettit George R; Hamel Ernest; Hogan Fiona; Moser Bryan R; Wolf Sonja; Pon Sandy; Chapuis Jean-Charles; Schmidt Jean M
E-Combretastatin and E-resveratrol structural modifications: antimicrobial and cancer cell growth inhibitory beta-E-nitrostyrenes.
Pettit Robin K; Weber Christine A; Lawrence Stacey B; Pettit George R; Kean Melissa J; Cage Gary D
In vivo activity of anprocide alone, and in vitro activity in combination with conventional antibiotics against Staphylococcus aureus and Staphylococcus epidermidis biofilms.

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All Publications

2009: Pettit George R; Melody Noeleen; Thornhill Andrew; Knight John C; Groy Thomas L; Herald Cherry L
Antineoplastic agents. 579. Synthesis and cancer cell growth evaluation of E-stilstatin 3: a resveratrol structural modification.
Journal of natural products 2009;72(9):1637-42.
2009: Pettit Robin K; Pettit George R; Hamel Ernest; Hogan Fiona; Moser Bryan R; Wolf Sonja; Pon Sandy; Chapuis Jean-Charles; Schmidt Jean M
E-Combretastatin and E-resveratrol structural modifications: antimicrobial and cancer cell growth inhibitory beta-E-nitrostyrenes.
Bioorganic & medicinal chemistry 2009;17(18):6606-12.
2009: Pettit Robin K; Weber Christine A; Lawrence Stacey B; Pettit George R; Kean Melissa J; Cage Gary D
In vivo activity of anprocide alone, and in vitro activity in combination with conventional antibiotics against Staphylococcus aureus and Staphylococcus epidermidis biofilms.
Journal of medical microbiology 2009;58(Pt 9):1203-6.
2009: Pettit George R; Ducki Sylvie; Eastham Stephen A; Melody Noeleen
Antineoplastic agents. 454. Synthesis of the strong cancer cell growth inhibitors trans-dihydronarciclasine and 7-deoxy-trans-dihydronarciclasine (1a).
Journal of natural products 2009;72(7):1279-82.
2009: Pettit George R; Thornhill Andrew; Melody Noeleen; Knight John C
Antineoplastic Agents. 578. Synthesis of Stilstatins 1 and 2 and Their Water-Soluble Prodrugs (dagger).
Journal of natural products 2009;72(3):380-8.
2009: Pettit George R; Knight John C; Herald Delbert L; Pettit Robin K; Hogan Fiona; Mukku Venugopal J R V; Hamblin John S; Dodson Michael J; Chapuis Jean-Charles
Antineoplastic Agents. 570. Isolation and Structure Elucidation of Bacillistatins 1 and 2 from a Marine Bacillus silvestris (dagger) (,) (double dagger).
Journal of natural products 2009;72(3):366-71.
2009: Bai Ruoli; Edler Michael C; Bonate Peter L; Copeland Terry D; Pettit George R; Ludueña Richard F; Hamel Ernest
Intracellular activation and deactivation of tasidotin, an analog of dolastatin 15: correlation with cytotoxicity.
Molecular pharmacology 2009;75(1):218-26.
2009: Pettit Robin K; Weber Christine A; Pettit George R
Application of a high throughput Alamar blue biofilm susceptibility assay to Staphylococcus aureus biofilms.
Annals of clinical microbiology and antimicrobials 2009;8():28.
2008: Rudy A; López-Antón N; Barth N; Pettit G R; Dirsch V M; Schulze-Osthoff K; Rehm M; Prehn J H M; Vogler M; Fulda S; Vollmar A M
Role of Smac in cephalostatin-induced cell death.
Cell death and differentiation 2008;15(12):1930-40.
2008: James C; Pettit G R; Nielsen O F; Jayakumar V S; Joe I Hubert
Vibrational spectra and ab initio molecular orbital calculations of the novel anti-cancer drug combretastatin A-4 prodrug.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 2008;70(5):1208-16.
2008: Pettit George R; Thornhill Andrew J; Moser Bryan R; Hogan Fiona
Antineoplastic agents. 552. Oxidation of combretastatin A-1: trapping the o-quinone intermediate considered the metabolic product of the corresponding phosphate prodrug.
Journal of natural products 2008;71(9):1561-3.
2008: Hall John J; Sriram Madhavi; Strecker Tracy E; Tidmore Justin K; Jelinek Christopher J; Kumar G D Kishore; Hadimani Mallinath B; Pettit George R; Chaplin David J; Trawick Mary Lynn; Pinney Kevin G
Design, synthesis, biochemical, and biological evaluation of nitrogen-containing trifluoro structural modifications of combretastatin A-4.
Bioorganic & medicinal chemistry letters 2008;18(18):5146-9.
2008: Schyschka L; Rudy A; Jeremias I; Barth N; Pettit G R; Vollmar A M
Spongistatin 1: a new chemosensitizing marine compound that degrades XIAP.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2008;22(9):1737-45.
2008: Pettit George R; Hogan Fiona; Xu Jun-Ping; Tan Rui; Nogawa Toshihiko; Cichacz Zbigniew; Pettit Robin K; Du Jiang; Ye Qing-Hua; Cragg Gordon M; Herald Cherry L; Hoard Michael S; Goswami Animesh; Searcy Justin; Tackett Larry; Doubek Dennis L; Williams Lee; Hooper John N A; Schmidt Jean M; Chapuis Jean-Charles; Tackett Denise N; Craciunescu Felicia
Antineoplastic agents. 536. New sources of naturally occurring cancer cell growth inhibitors from marine organisms, terrestrial plants, and microorganisms(1a,).
Journal of natural products 2008;71(3):438-44.
2008: Siles Rogelio; Ackley J Freeland; Hadimani Mallinath B; Hall John J; Mugabe Benon E; Guddneppanavar Rajsekhar; Monk Keith A; Chapuis Jean-Charles; Pettit George R; Chaplin David J; Edvardsen Klaus; Trawick Mary Lynn; Garner Charles M; Pinney Kevin G
Combretastatin dinitrogen-substituted stilbene analogues as tubulin-binding and vascular-disrupting agents.
Journal of natural products 2008;71(3):313-20.
2008: Brennan Mary R; Costello Catherine E; Maleknia Simin D; Pettit George R; Erickson Karen L
Stylopeptide 2, a proline-rich cyclodecapeptide from the sponge Stylotella sp.
Journal of natural products 2008;71(3):453-6.
2008: Repp K K; Hogan F; Pettit G R; Pettit R K
In vitro interactions of approved and experimental drugs against Candida drugs against Candida spp.
Journal of chemotherapy (Florence, Italy) 2008;20(1):137-9.
2008: Smith Amos B; Razler Thomas M; Meis Regina M; Pettit George R
Synthesis and biological evaluation of phorboxazole congeners leading to the discovery and preparative-scale synthesis of (+)-chlorophorboxazole a possessing picomolar human solid tumor cell growth inhibitory activity.
The Journal of organic chemistry 2008;73(4):1201-8.
2008: Pettit George R; Mukku Venugopal J R V; Cragg Gordon; Herald Delbert L; Knight John C; Herald Cherry L; Chapuis Jean-Charles
Antineoplastic agents. 558. Ampelocissus sp. cancer cell growth inhibitory constituents.
Journal of natural products 2008;71(1):130-3.
2007: Shnyder Steven D; Cooper Patricia A; Millington Nicola J; Pettit G Robert; Bibby Michael C
Auristatin PYE, a novel synthetic derivative of dolastatin 10, is highly effective in human colon tumour models.
International journal of oncology 2007;31(2):353-60.
2007: Pettit George R; Smith Thomas H; Feng Song; Knight John C; Tan Rui; Pettit Robin K; Hinrichs Peter A
Antineoplastic agents. 561. Total synthesis of respirantin.
Journal of natural products 2007;70(7):1073-83.
2007: Pettit George R; Tan Rui; Pettit Robin K; Smith Thomas H; Feng Song; Doubek Dennis L; Richert Linda; Hamblin John; Weber Christine; Chapuis Jean-Charles
Antineoplastic agents. 560. Isolation and structure of kitastatin 1 from an Alaskan Kitasatospora sp.
Journal of natural products 2007;70(7):1069-72.
2007: Pettit George R; Melody Noeleen; Herald Delbert L; Knight John C; Chapuis Jean-Charles
Antineoplastic agents. 550. Synthesis of 10b(s)-epipancratistatin from (+)-narciclasine.
Journal of natural products 2007;70(3):417-22.
2006: Dabydeen Donnette A; Burnett James C; Bai Ruoli; Verdier-Pinard Pascal; Hickford Sarah J H; Pettit George R; Blunt John W; Munro Murray H G; Gussio Rick; Hamel Ernest
Comparison of the activities of the truncated halichondrin B analog NSC 707389 (E7389) with those of the parent compound and a proposed binding site on tubulin.
Molecular pharmacology 2006;70(6):1866-75.
2006: López-Antón Nancy; Rudy Anita; Barth Nicole; Schmitz M Lienhard; Pettit George R; Schulze-Osthoff Klaus; Dirsch Verena M; Vollmar Angelika M
The marine product cephalostatin 1 activates an endoplasmic reticulum stress-specific and apoptosome-independent apoptotic signaling pathway.
The Journal of biological chemistry 2006;281(44):33078-86.
2006: LaMarca H L; Morris C A; Pettit G R; Nagowa T; Puschett J B
Marinobufagenin impairs first trimester cytotrophoblast differentiation.
Placenta 2006;27(9-10):984-8.
2006: Pettit George R; Du Jiang; Pettit Robin K; Richert Linda A; Hogan Fiona; Mukku Venugopal J R V; Hoard Michael S
Antineoplastic Agents. 554. The manitoba bacterium Streptomyces sp.
Journal of natural products 2006;69(5):804-6.
2006: Monk Keith A; Siles Rogelio; Hadimani Mallinath B; Mugabe Benon E; Ackley J Freeland; Studerus Scott W; Edvardsen Klaus; Trawick Mary Lynn; Garner Charles M; Rhodes Monte R; Pettit George R; Pinney Kevin G
Design, synthesis, and biological evaluation of combretastatin nitrogen-containing derivatives as inhibitors of tubulin assembly and vascular disrupting agents.
Bioorganic & medicinal chemistry 2006;14(9):3231-44.
2006: Pettit George R; Numata Atsushi; Iwamoto Chika; Usami Yoshihide; Yamada Takeshi; Ohishi Hirofumi; Cragg Gordon M
Antineoplastic agents. 551. Isolation and structures of bauhiniastatins 1-4 from Bauhinia purpurea.
Journal of natural products 2006;69(3):323-7.
2006: Smith Amos B; Razler Thomas M; Meis Regina M; Pettit George R
Design and synthesis of a potent phorboxazole C(11-15) acetal analogue.
Organic letters 2006;8(4):797-9.
2006: Vu Hop; Ianosi-Irimie Monica; Danchuk Svitlana; Rabon Edd; Nogawa Toshihiko; Kamano Yoshiaki; Pettit G Robert; Wiese Thomas; Puschett Jules B
Resibufogenin corrects hypertension in a rat model of human preeclampsia.
Experimental biology and medicine (Maywood, N.J.) 2006;231(2):215-20.
2006: Pettit George R; Eastham Stephen A; Melody Noeleen; Orr Brian; Herald Delbert L; McGregor Jane; Knight John C; Doubek Dennis L; Pettit George R; Garner Lynnette C; Bell Joy A
Isolation and structural modification of 7-deoxynarciclasine and 7-deoxy-trans-dihydronarciclasine.
Journal of natural products 2006;69(1):7-13.
2006: Pettit George R; Eastham Stephen A; Melody Noeleen; Orr Brian; Herald Delbert L; McGregor Jane; Knight John C; Doubek Dennis L; Pettit George R; Garner Lynnette C; Bell Joy A
Isolation and structural modification of 7-deoxynarciclasine and 7-deoxy-trans-dihydronarciclasine.
Journal of natural products 2006;69(1):7-13.
2005: Pettit George R; Minardi Mathew D; Rosenberg Heidi J; Hamel Ernest; Bibby Michael C; Martin Sandie W; Jung M Katherine; Pettit Robin K; Cuthbertson Timothy J; Chapuis Jean-Charles
Antineoplastic agents. 509: synthesis of fluorcombstatin phosphate and related 3-halostilbenes(1).
Journal of natural products 2005;68(10):1450-8.
2005: Smith Amos B; Razler Thomas M; Pettit George R; Chapuis Jean-Charles
(+)-Phorboxazole A synthetic studies. Identification of a series of highly cytotoxic C(45-46) analogues.
Organic letters 2005;7(20):4403-6.
2005: Pettit Robin K; Woyke Tanja; Pon Sandy; Cichacz Zbigniew A; Pettit George R; Herald Cherry L
In vitro and in vivo antifungal activities of the marine sponge constituent spongistatin.
Medical mycology : official publication of the International Society for Human and Animal Mycology 2005;43(5):453-63.
2005: Pettit George R; Meng Yanhui; Herald Delbert L; Knight John C; Day John F
Antineoplastic agents. 553. The Texas grasshopper Brachystola magna.
Journal of natural products 2005;68(8):1256-8.
2005: Pettit George R; Tan Rui; Cichacz Zbigniew A
Antineoplastic agents. 542. Isolation and structure of sesterstatin 6 from the Indian Ocean sponge Hyrtios erecta.
Journal of natural products 2005;68(8):1253-5.
2005: Pettit George R; Anderson Collin R; Gapud Eric J; Jung M Katherine; Knight John C; Hamel Ernest; Pettit Robin K
Antineoplastic agents. 515. Synthesis of human cancer cell growth inhibitors derived from 3,4-methylenedioxy-5,4'-dimethoxy-3'-amino-Z-stilbene.
Journal of natural products 2005;68(8):1191-7.
2005: Pettit George R; Tang Yuping; Knight John C
Antineoplastic agents. 545. Isolation and structure of turbostatins 1-4 from the Asian marine mollusk Turbo stenogyrus.
Journal of natural products 2005;68(7):974-8.
2005: Pettit Robin K; Weber Christine A; Kean Melissa J; Hoffmann Holger; Pettit George R; Tan Rui; Franks Kelly S; Horton Marilyn L
Microplate Alamar blue assay for Staphylococcus epidermidis biofilm susceptibility testing.
Antimicrobial agents and chemotherapy 2005;49(7):2612-7.
2005: Ali Md Ahad; Bates Robert B; Crane Zackary D; Dicus Christopher W; Gramme Michelle R; Hamel Ernest; Marcischak Jacob; Martinez David S; McClure Kelly J; Nakkiew Pichaya; Pettit George R; Stessman Chad C; Sufi Bilal A; Yarick Gayle V
Dolastatin 11 conformations, analogues and pharmacophore.
Bioorganic & medicinal chemistry 2005;13(13):4138-52.
2005: Pettit George R; Rhodes Monte R; Herald Delbert L; Hamel Ernest; Schmidt Jean M; Pettit Robin K
Antineoplastic agents. 445. Synthesis and evaluation of structural modifications of (Z)- and (E)-combretastatin A-41.
Journal of medicinal chemistry 2005;48(12):4087-99.
2005: Pettit George R; Zhang Qingwen; Pinilla Veronique; Hoffmann Holger; Knight John C; Doubek Dennis L; Chapuis Jean-Charles; Pettit Robin K; Schmidt Jean M
Antineoplastic agents. 534. isolation and structure of sansevistatins 1 and 2 from the African Sansevieria ehrenbergii.
Journal of natural products 2005;68(5):729-33.
2005: Müller Irina M; Dirsch Verena M; Rudy Anita; López-Antón Nancy; Pettit George R; Vollmar Angelika M
Cephalostatin 1 inactivates Bcl-2 by hyperphosphorylation independent of M-phase arrest and DNA damage.
Molecular pharmacology 2005;67(5):1684-9.
2005: Pettit George R; Melody Noeleen
Antineoplastic agents. 527. Synthesis of 7-deoxynarcistatin, 7-deoxy-trans-dihydronarcistatin, and trans-dihydronarcistatin 1(1).
Journal of natural products 2005;68(2):207-11.
2005: Pettit George R; Tan Rui
Isolation and structure of phakellistatin 14 from the Western Pacific marine sponge Phakellia sp.
Journal of natural products 2005;68(1):60-3.
2005: Pettit George R; Meng Yanhui; Herald Delbert L; Stevens Andrew M; Pettit Robin K; Doubek Dennis L
Antineoplastic agents 540. The Indian Gynandropsis gynandra (Capparidaceae).
Oncology research 2005;15(2):59-68.
2005: Pettit George R; Ducki Sylvie; Herald Delbert L; Doubek Dennis L; Schmidt Jean M; Chapuis Jean-Charles
Antineoplastic agents 470. Absolute configuration of the marine sponge bromopyrrole agelastatin A.
Oncology research 2005;15(1):11-20.
2004: Suggitt Marie; Swaine David J; Pettit George R; Bibby Michael C
Characterization of the hollow fiber assay for the determination of microtubule disruption in vivo.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(19):6677-85.
2004: Rinner Uwe; Hudlicky Tomas; Gordon Heather; Pettit George R
A beta-carboline-1-one mimic of the anticancer Amaryllidaceae constituent pancratistatin: synthesis and biological evaluation.
Angewandte Chemie (International ed. in English) 2004;43(40):5342-6.
2004: Pettit George R; Nogawa Toshihiko; Knight John C; Doubek Dennis L; Hooper J N A
Antineoplastic agents. 535. Isolation and structure of plakorstatins 1 and 2 from the Indo-Pacific sponge Plakortis nigra.
Journal of natural products 2004;67(9):1611-3.
2004: Pettit George R; Tan Rui; Northen Julian S; Herald Delbert L; Chapuis Jean-Charles; Pettit Robin K
Antineoplastic agents. 529. Isolation and structure of nootkastatins 1 and 2 from the Alaskan yellow cedar Chamaecyparis nootkatensis.
Journal of natural products 2004;67(9):1476-82.
2004: Pettit George R; Xu Jun-Ping; Doubek Dennis L; Chapuis Jean-Charles; Schmidt Jean M
Antineoplastic Agents. 510. Isolation and structure of dolastatin 19 from the Gulf of California sea hare Dolabella auricularia.
Journal of natural products 2004;67(8):1252-5.
2004: Bai Ruoli; Covell David G; Taylor George F; Kepler John A; Copeland Terry D; Nguyen Nga Y; Pettit George R; Hamel Ernest
Direct photoaffinity labeling by dolastatin 10 of the amino-terminal peptide of beta-tubulin containing cysteine 12.
The Journal of biological chemistry 2004;279(29):30731-40.
2004: Pettit George R; Zhang Qingwen; Pinilla Véronique; Herald Delbert L; Doubek Dennis L; Duke James A
Isolation and structure of gustastatin from the Brazilian nut tree Gustavia hexapetala.
Journal of natural products 2004;67(6):983-5.
2004: Pettit George R; Hogan Fiona; Herald Delbert L
Synthesis and X-ray crystal structure of the dolabellaauricularia peptide dolastatin 18.
The Journal of organic chemistry 2004;69(12):4019-22.
2004: Rinner Uwe; Hillebrenner Heather L; Adams David R; Hudlicky Tomas; Pettit George R
Synthesis and biological activity of some structural modifications of pancratistatin.
Bioorganic & medicinal chemistry letters 2004;14(11):2911-5.
2004: Pettit George R; Hoffmann Holger; Herald Delbert L; McNulty James; Murphy Alison; Higgs Kerianne C; Hamel Ernest; Lewin Nancy E; Pearce Larry V; Blumberg Peter M; Pettit Robin K; Knight John C
Antineoplastic agents 491. Synthetic conversion of aaptamine to isoaaptamine, 9-demethylaaptamine, and 4-methylaaptamine.
The Journal of organic chemistry 2004;69(7):2251-6.
2004: Pettit George R; Hoffmann Holger; McNulty James; Higgs Kerianne C; Murphy Alison; Molloy David J; Herald Delbert L; Williams Michael D; Pettit Robin K; Doubek Dennis L; Hooper John N A; Albright Leslie; Schmidt Jean M; Chapuis Jean-Charles; Tackett Larry P
Antineoplastic agents. 380. Isolation and X-ray crystal structure determination of isoaaptamine from the Republic of Singapore Hymeniacidon sp. and conversion to the phosphate prodrug hystatin 1.
Journal of natural products 2004;67(3):506-9.
2004: Pettit George R; Melody Noeleen; Herald Delbert L
Antineoplastic agents. 511. Direct phosphorylation of phenpanstatin and pancratistatin.
Journal of natural products 2004;67(3):322-7.
2004: Pettit George R; Hoffmann Holger; Herald Delbert L; Blumberg Peter M; Hamel Ernest; Schmidt Jean M; Chang Yung; Pettit Robin K; Lewin Nancy E; Pearce Larry V
Antineoplastic agents. 499. Synthesis of hystatin 2 and related 1H-benzo[de][1,6]-naphthyridinium salts from aaptamine.
Journal of medicinal chemistry 2004;47(7):1775-82.
2004: Dang Long H; Bettegowda Chetan; Agrawal Nishant; Cheong Ian; Huso David; Frost Philip; Loganzo Frank; Greenberger Lee; Barkoczy Jozsef; Pettit George R; Smith Amos B; Gurulingappa Hallur; Khan Saeed; Parmigiani Giovanni; Kinzler Kenneth W; Zhou Shibin; Vogelstein Bert
Targeting vascular and avascular compartments of tumors with C. novyi-NT and anti-microtubule agents.
Cancer biology & therapy 2004;3(3):326-37.
2004: Pettit George R; Meng Yanhui; Gearing R Patrick; Herald Delbert L; Pettit Robin K; Doubek Dennis L; Chapuis Jean-Charles; Tackett Larry P
Antineoplastic agents. 522. Hernandia peltata (Malaysia) and Hernandia nymphaeifolia (Republic of Maldives).
Journal of natural products 2004;67(2):214-20.
2004: Kirwan Ian G; Loadman Paul M; Swaine David J; Anthoney D Alan; Pettit George R; Lippert John W; Shnyder Steve D; Cooper Patricia A; Bibby Mike C
Comparative preclinical pharmacokinetic and metabolic studies of the combretastatin prodrugs combretastatin A4 phosphate and A1 phosphate.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(4):1446-53.
2004: Pettit George R; Xu Jun-Ping; Chapuis Jean-Charles; Pettit Robin K; Tackett Larry P; Doubek Dennis L; Hooper John N A; Schmidt Jean M
Antineoplastic agents. 520. Isolation and structure of irciniastatins A and B from the Indo-Pacific marine sponge Ircinia ramosa.
Journal of medicinal chemistry 2004;47(5):1149-52.
2004: Woyke Tanja; Berens Michael E; Hoelzinger Dominique B; Pettit George R; Winkelmann Günther; Pettit Robin K
Differential gene expression in auristatin PHE-treated Cryptococcus neoformans.
Antimicrobial agents and chemotherapy 2004;48(2):561-7.
2004: Pettit Robin K; Fakoury Bridget R; Knight John C; Weber Christine A; Pettit George R; Cage Gary D; Pon Sandy
Antibacterial activity of the marine sponge constituent cribrostatin 6.
Journal of medical microbiology 2004;53(Pt 1):61-5.
2003: Dirsch Verena M; Müller Irina M; Eichhorst Sören T; Pettit George R; Kamano Yoshiaki; Inoue Masuo; Xu Jun-Ping; Ichihara Yoshitatsu; Wanner Gerhard; Vollmar Angelika M
Cephalostatin 1 selectively triggers the release of Smac/DIABLO and subsequent apoptosis that is characterized by an increased density of the mitochondrial matrix.
Cancer research 2003;63(24):8869-76.
2003: Cruz-Monserrate Zobeida; Mullaney Jeffrey T; Harran Patrick G; Pettit George R; Hamel Ernest
Dolastatin 15 binds in the vinca domain of tubulin as demonstrated by Hummel-Dreyer chromatography.
European journal of biochemistry / FEBS 2003;270(18):3822-8.
2003: Ali Shadan; Aranha Olivia; Li Yiwei; Pettit George R; Sarkar Fazlul H; Philip Philip Agop
Sensitization of human breast cancer cells to gemcitabine by the protein kinase C modulator bryostatin 1.
Cancer chemotherapy and pharmacology 2003;52(3):235-46.
2003: Pettit George R; Meng Yanhui; Herald Delbert L; Graham Keith A N; Pettit Robin K; Doubek Dennis L
Isolation and structure of ruprechstyril from Ruprechtia tangarana.
Journal of natural products 2003;66(8):1065-9.
2003: Cruz-Monserrate Zobeida; Vervoort Hélène C; Bai Ruoli; Newman David J; Howell Stephen B; Los Gerrit; Mullaney Jeffrey T; Williams Michael D; Pettit George R; Fenical William; Hamel Ernest
Diazonamide A and a synthetic structural analog: disruptive effects on mitosis and cellular microtubules and analysis of their interactions with tubulin.
Molecular pharmacology 2003;63(6):1273-80.
2003: Pettit George R; Collins Jeremiah C; Knight John C; Herald Delbert L; Nieman Ronald A; Williams Michael D; Pettit Robin K
Antineoplastic agents. 485. Isolation and structure of cribrostatin 6, a dark blue cancer cell growth inhibitor from the marine sponge Cribrochalina sp.
Journal of natural products 2003;66(4):544-7.
2003: Fennell B J; Carolan S; Pettit G R; Bell A
Effects of the antimitotic natural product dolastatin 10, and related peptides, on the human malarial parasite Plasmodium falciparum.
The Journal of antimicrobial chemotherapy 2003;51(4):833-41.
2003: Shnyder S D; Cooper P A; Pettit G R; Lippert J W; Bibby M C
Combretastatin A-1 phosphate potentiates the antitumour activity of cisplatin in a murine adenocarcinoma model.
Anticancer research 2003;23(2B):1619-23.
2003: Hua Jianyi; Sheng Yezhou; Pinney Kevin G; Garner Charles M; Kane Robert R; Prezioso Joseph A; Pettit George R; Chaplin David J; Edvardsen Klaus
Oxi4503, a novel vascular targeting agent: effects on blood flow and antitumor activity in comparison to combretastatin A-4 phosphate.
Anticancer research 2003;23(2B):1433-40.
2003: Pettit George R; Tan Rui
Antineoplastic agents 390. Isolation and structure of phakellistatin 12 from a Chuuk archipelago marine sponge.
Bioorganic & medicinal chemistry letters 2003;13(4):685-8.
2003: Pettit George R; Tan Rui; Herald Delbert L; Hamblin John; Pettit Robin K
Antineoplastic agents. 488. Isolation and structure of yukonin from a yukon territory fungus.
Journal of natural products 2003;66(2):276-8.
2003: Pettit George R; Meng Yanhui; Stevenson Clare A; Doubek Dennis L; Knight John C; Cichacz Zbigniew; Pettit Robin K; Chapuis Jean-Charles; Schmidt Jean M
Isolation and structure of palstatin from the Amazon tree Hymeneae palustris(1).
Journal of natural products 2003;66(2):259-62.
2003: Pettit George R; Anderson Collin R; Herald Delbert L; Jung M Katherine; Lee Debbie J; Hamel Ernest; Pettit Robin K
Antineoplastic agents. 487. Synthesis and biological evaluation of the antineoplastic agent 3,4-methylenedioxy-5,4'-dimethoxy-3'-amino-Z-stilbene and derived amino acid amides.
Journal of medicinal chemistry 2003;46(4):525-31.
2003: Pettit George R; Melody Noeleen; Simpson Michael; Thompson Michael; Herald Delbert L; Knight John C
Antineoplastic agents 500. Narcistatin.
Journal of natural products 2003;66(1):92-6.
2002: Pettit George R; Numata Atsushi; Iwamoto Chika; Morito Hideaki; Yamada Takeshi; Goswami Animesh; Clewlow Paul J; Cragg Gordon M; Schmidt Jean M
Antineoplastic agents. 489. Isolation and structures of meliastatins 1-5 and related euphane triterpenes from the tree Melia dubia.
Journal of natural products 2002;65(12):1886-91.
2002: Bai Ruoli; Bates Robert B; Hamel Ernest; Moore Richard E; Nakkiew Pichaya; Pettit George R; Sufi Bilal A
Lyngbyastatin 1 and Ibu-epilyngbyastatin 1: synthesis, stereochemistry, and NMR line broadening.
Journal of natural products 2002;65(12):1824-9.
2002: Pettit George R; Knight John C; Herald Delbert L; Davenport Richard; Pettit Robin K; Tucker Bruce E; Schmidt Jean M
Isolation of labradorins 1 and 2 from Pseudomonas syringae pv. coronafaciens.
Journal of natural products 2002;65(12):1793-7.
2002: Hudlicky Tomas; Rinner Uwe; Gonzalez David; Akgun Hulya; Schilling Stefan; Siengalewicz Peter; Martinot Theodore A; Pettit George R
Total synthesis and biological evaluation of Amaryllidaceae alkaloids: narciclasine, ent-7-deoxypancratistatin, regioisomer of 7-deoxypancratistatin, 10b-epi-deoxypancratistatin, and truncated derivatives.
The Journal of organic chemistry 2002;67(25):8726-43.
2002: Kamano Yoshiaki; Yamashita Ayano; Nogawa Toshihiko; Morita Hiroshi; Takeya Koichi; Itokawa Hideji; Segawa Toshiaki; Yukita Ayako; Saito Kyoko; Katsuyama Mariko; Pettit George R
QSAR evaluation of the Ch'an Su and related bufadienolides against the colchicine-resistant primary liver carcinoma cell line PLC/PRF/5(1).
Journal of medicinal chemistry 2002;45(25):5440-7.
2002: Woyke Tanja; Roberson Robert W; Pettit George R; Winkelmann Günther; Pettit Robin K
Effect of auristatin PHE on microtubule integrity and nuclear localization in Cryptococcus neoformans.
Antimicrobial agents and chemotherapy 2002;46(12):3802-8.
2002: Holwell S E; Cooper P A; Thompson M J; Pettit G R; Lippert L W; Martin S W; Bibby M C
Anti-tumor and anti-vascular effects of the novel tubulin-binding agent combretastatin A-1 phosphate.
Anticancer research 2002;22(6C):3933-40.
2002: Pettit George R; Ducki Sylvie; Tan Rui; Gardella Roberta S; McMahon James B; Boyd Michael R; Pettit George R; Blumberg Peter M; Lewin Nancy E; Doubek Dennis L; Tackett Larry P; Williams Michael D
Isolation and structure of pedilstatin from a republic of maldives Pedilanthus sp.
Journal of natural products 2002;65(9):1262-5.
2002: Pettit George R; Ducki Sylvie; Tan Rui; Gardella Roberta S; McMahon James B; Boyd Michael R; Pettit George R; Blumberg Peter M; Lewin Nancy E; Doubek Dennis L; Tackett Larry P; Williams Michael D
Isolation and structure of pedilstatin from a republic of maldives Pedilanthus sp.
Journal of natural products 2002;65(9):1262-5.
2002: Nabha Sanaa M; Mohammad Ramzi M; Dandashi Mahmoud H; Coupaye-Gerard Brigitte; Aboukameel Amro; Pettit George R; Al-Katib Ayad M
Combretastatin-A4 prodrug induces mitotic catastrophe in chronic lymphocytic leukemia cell line independent of caspase activation and poly(ADP-ribose) polymerase cleavage.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(8):2735-41.
2002: Smith Amos B; Corbett R Michael; Pettit George R; Chapuis Jean Charles; Schmidt Jean M; Hamel Ernest; Jung M Katherine
Synthesis and biological evaluation of a spongistatin AB-spiroketal analogue.
Bioorganic & medicinal chemistry letters 2002;12(15):2039-42.
2002: Kamano Yoshiaki; Nogawa Toshihiko; Yamashita Ayano; Hayashi Masahiko; Inoue Masuo; Drasar Pavel; Pettit George R
Isolation and structure of a 20,21-epoxybufenolide series from "Ch'an Su".
Journal of natural products 2002;65(7):1001-5.
2002: Pettit George R; Grealish Matthew P; Jung M Katherine; Hamel Ernest; Pettit Robin K; Chapuis J-Charles; Schmidt Jean M
Antineoplastic agents. 465. Structural modification of resveratrol: sodium resverastatin phosphate.
Journal of medicinal chemistry 2002;45(12):2534-42.
2002: Hill Sally A; Toze Gillian M; Pettit George R; Chaplin David J
Preclinical evaluation of the antitumour activity of the novel vascular targeting agent Oxi 4503.
Anticancer research 2002;22(3):1453-8.
2002: Pettit R K; Hamel E; Verdier-Pinard P; Roberson R W; Hazen K C; Pettit G R; Crews Laura C
Antifungal and cancer cell growth inhibitory activities of 1-(3',4',5'-trimethoxyphenyl)-2-nitro-ethylene.
Mycoses 2002;45(3-4):65-74.
2002: Holwell S E; Cooper P A; Grosios K; Lippert J W; Pettit G R; Shnyder S D; Bibby M C
Combretastatin A-1 phosphate a novel tubulin-binding agent with in vivo anti vascular effects in experimental tumours.
Anticancer research 2002;22(2A):707-11.
2002: Thamm Douglas H; MacEwen E Gregory; Phillips Brenda S; Hershey A Elizabeth; Burgess Kristine M; Pettit George R; Vail David M
Preclinical study of dolastatin-10 in dogs with spontaneous neoplasia.
Cancer chemotherapy and pharmacology 2002;49(3):251-5.
2001: Smith A B; Cho Y S; Zawacki L E; Hirschmann R; Pettit G R
First generation design, synthesis, and evaluation of azepine-based cryptophycin analogues.
Organic letters 2001;3(25):4063-6.
2001: Pettit G R; Grealish M P
A cobalt-phosphine complex directed Reformatsky approach to a stereospecific synthesis of the dolastatin 10 unit dolaproine (Dap).
The Journal of organic chemistry 2001;66(25):8640-2.
2001: Woyke T; Pettit G R; Winkelmann G; Pettit R K
In vitro activities and postantifungal effects of the potent dolastatin 10 derivative auristatin PHE.
Antimicrobial agents and chemotherapy 2001;45(12):3580-4.
2001: Ouarzane-Amara M; Franetich J F; Mazier D; Pettit G R; Meijer L; Doerig C; Desportes-Livage I
In vitro activities of two antimitotic compounds, pancratistatin and 7-deoxynarciclasine, against Encephalitozoon intestinalis, a microsporidium causing infections in humans.
Antimicrobial agents and chemotherapy 2001;45(12):3409-15.
2001: Mohammad R M; Adsay N V; Philip P A; Pettit G R; Vaitkevicius V K; Sarkar F H
Bryostatin 1 induces differentiation and potentiates the antitumor effect of Auristatin PE in a human pancreatic tumor (PANC-1) xenograft model.
Anti-cancer drugs 2001;12(9):735-40.
2001: Nogawa T; Kamano Y; Yamashita A; Pettit G R
Isolation and structure of five new cancer cell growth inhibitory bufadienolides from the Chinese traditional drug Ch'an Su.
Journal of natural products 2001;64(9):1148-52.
2001: Pettit G R; Moser B R; Boyd M R; Schmidt J M; Pettit R K; Chapuis J C
Antineoplastic agents 460. Synthesis of combretastatin A-2 prodrugs.
Anti-cancer drug design 2001;16(4-5):185-93.
2001: Pettit G R; Lippert J W; Taylor S R; Tan R; Williams M D
Synthesis of phakellistatin 11: a micronesia (Chuuk) marine sponge cyclooctapeptide.
Journal of natural products 2001;64(7):883-91.
2001: Duffield J J; Pettit G R
Synthesis of (7S,15S)- and (7R,15S)-dolatrienoic acid.
Journal of natural products 2001;64(4):472-9.
2001: Pettit G R; Melody N; Herald D L
Antineoplastic agents. 450. Synthesis of (+)-pancratistatin from (+)-narciclasine as relay(1a).
The Journal of organic chemistry 2001;66(8):2583-7.
2001: Bai R; Verdier-Pinard P; Gangwar S; Stessman C C; McClure K J; Sausville E A; Pettit G R; Bates R B; Hamel E
Dolastatin 11, a marine depsipeptide, arrests cells at cytokinesis and induces hyperpolymerization of purified actin.
Molecular pharmacology 2001;59(3):462-9.
2001: Nabha S M; Mohammad R M; Wall N R; Dutcher J A; Salkini B M; Pettit G R; Al-Katib A M
Evaluation of combretastatin A-4 prodrug in a non-Hodgkin's lymphoma xenograft model: preclinical efficacy.
Anti-cancer drugs 2001;12(1):57-63.
2001: McNulty J; Mao J; Gibe R; Mo R; Wolf S; Pettit G R; Herald D L; Boyd M R
Studies directed towards the refinement of the pancratistatin cytotoxic pharmacophore.
Bioorganic & medicinal chemistry letters 2001;11(2):169-72.
2000: Pettit G R; Minardi M D; Boyd M R; Pettit R K
Antineoplastic agents 463. Synthesis of combretastatin A-3 diphosphate prodrugs.
Anti-cancer drug design 2000;15(6):397-403.
2000: Pettit G R; Orr B; Ducki S
Antineoplastic agents 453. Synthesis of pancratistatin prodrugs.
Anti-cancer drug design 2000;15(6):389-95.
2000: Chen Z; Mocharla V P; Farmer J M; Pettit G R; Hamel E; Pinney K G
Preparation of new anti-tubulin ligands through a dual-mode, addition-elimination reaction to a bromo-substituted alpha, beta-unsaturated sulfoxide.
The Journal of organic chemistry 2000;65(25):8811-5.
2000: Clarke H; Ginanni N; Laughlin K V; Smith J B; Pettit G R; Mullin J M
The transient increase of tight junction permeability induced by bryostatin 1 correlates with rapid downregulation of protein kinase C-alpha.
Experimental cell research 2000;261(1):239-49.
2000: Pettit G R; Lippert J W; Herald D L
A pinacol rearrangement/oxidation synthetic route to hydroxyphenstatin.
The Journal of organic chemistry 2000;65(22):7438-44.
2000: Pettit G R; Lippert J W; Boyd M R; Verdier-Pinard P; Hamel E
Antineoplastic agents 442. Synthesis and biological activities of dioxostatin.
Anti-cancer drug design 2000;15(5):361-71.
2000: Pinney K G; Mejia M P; Villalobos V M; Rosenquist B E; Pettit G R; Verdier-Pinard P; Hamel E
Synthesis and biological evaluation of aryl azide derivatives of combretastatin A-4 as molecular probes for tubulin.
Bioorganic & medicinal chemistry 2000;8(10):2417-25.
2000: Chen C; Lin H; Karanes C; Pettit G R; Chen B D
Human THP-1 monocytic leukemic cells induced to undergo monocytic differentiation by bryostatin 1 are refractory to proteasome inhibitor-induced apoptosis.
Cancer research 2000;60(16):4377-85.
2000: Pettit R K; Cage G D; Pettit G R; Liebman J A
Antimicrobial and cancer cell growth inhibitory activities of 3beta-acetoxy-17beta-(L-prolyl)amino-5alpha-androstane in vitro.
International journal of antimicrobial agents 2000;15(4):299-304.
2000: Pettit G R; Lippert J W; Herald D L; Hamel E; Pettit R K
Antineoplastic agents 440. Asymmetric synthesis and evaluation of the combretastatin A-1 SAR probes (1S,2S)- and (1R,2R)-1, 2-dihydroxy- 1-(2',3'-dihydroxy-4'-methoxyphenyl)-2-(3' ',4' ',5' '-trimethoxyphenyl)-ethane.
Journal of natural products 2000;63(7):969-74.
2000: Pettit G R; Grealish M P; Herald D L; Boyd M R; Hamel E; Pettit R K
Antineoplastic agents. 443. Synthesis of the cancer cell growth inhibitor hydroxyphenstatin and its sodium diphosphate prodrug.
Journal of medicinal chemistry 2000;43(14):2731-7.
2000: He Z; Evelhoch J L; Mohammad R M; Adsay N V; Pettit G R; Vaitkevicius V K; Sarkar F H
Magnetic resonance imaging to measure therapeutic response using an orthotopic model of human pancreatic cancer.
Pancreas 2000;21(1):69-76.
2000: Pettit G R; Lippert J W
Antineoplastic agents 429. Syntheses of the combretastatin A-1 and combretastatin B-1 prodrugs.
Anti-cancer drug design 2000;15(3):203-16.
2000: Nabha S M; Wall N R; Mohammad R M; Pettit G R; Al-Katib A M
Effects of combretastatin A-4 prodrug against a panel of malignant human B-lymphoid cell lines.
Anti-cancer drugs 2000;11(5):385-92.
2000: Pettit G R; Knight J C; Collins J C; Herald D L; Pettit R K; Boyd M R; Young V G
Antineoplastic agents 430. Isolation and structure of cribrostatins 3, 4, and 5 from the republic of maldives cribrochalina species.
Journal of natural products 2000;63(6):793-8.
2000: Beutler J A; McCall K L; Herbert K; Herald D L; Pettit G R; Johnson T; Shoemaker R H; Boyd M R
Novel cytotoxic diterpenes from Casearia arborea.
Journal of natural products 2000;63(5):657-61.
2000: Lorenzo P S; Beheshti M; Pettit G R; Stone J C; Blumberg P M
The guanine nucleotide exchange factor RasGRP is a high -affinity target for diacylglycerol and phorbol esters.
Molecular pharmacology 2000;57(5):840-6.
2000: Grosios K; Loadman P M; Swaine D J; Pettit G R; Bibby M C
Combination chemotherapy with combretastatin A-4 phosphate and 5-fluorouracil in an experimental murine colon adenocarcinoma.
Anticancer research 2000;20(1A):229-33.
2000: Meijer L; Thunnissen A M; White A W; Garnier M; Nikolic M; Tsai L H; Walter J; Cleverley K E; Salinas P C; Wu Y Z; Biernat J; Mandelkow E M; Kim S H; Pettit G R
Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent.
Chemistry & biology 2000;7(1):51-63.
2000: Pettit G R; Numata A; Cragg G M; Herald D L; Takada T; Iwamoto C; Riesen R; Schmidt J M; Doubek D L; Goswami A
Isolation and structures of schleicherastatins 1-7 and schleicheols 1 and 2 from the teak forest medicinal tree Schleichera oleosa.
Journal of natural products 2000;63(1):72-8.
2000: Pettit G R; Toki B E; Xu J P; Brune D C
Synthesis of the marine sponge cycloheptapeptide phakellistatin 5(1).
Journal of natural products 2000;63(1):22-8.
2000: Verdier-Pinard P; Kepler J A; Pettit G R; Hamel E
Sustained intracellular retention of dolastatin 10 causes its potent antimitotic activity.
Molecular pharmacology 2000;57(1):180-7.
1999: Lorenzo P S; Bögi K; Hughes K M; Beheshti M; Bhattacharyya D; Garfield S H; Pettit G R; Blumberg P M
Differential roles of the tandem C1 domains of protein kinase C delta in the biphasic down-regulation induced by bryostatin 1.
Cancer research 1999;59(24):6137-44.
1999: Grosios K; Holwell S E; McGown A T; Pettit G R; Bibby M C
In vivo and in vitro evaluation of combretastatin A-4 and its sodium phosphate prodrug.
British journal of cancer 1999;81(8):1318-27.
1999: Wall N R; Mohammad R M; Nabha S M; Pettit G R; Al-Katib A M
Modulation of cIAP-1 by novel antitubulin agents when combined with bryostatin 1 results in increased apoptosis in the human early pre-B acute lymphoblastic leukemia cell line Reh.
Biochemical and biophysical research communications 1999;266(1):76-80.
1999: Mohammad R M; Li Y; Mohamed A N; Pettit G R; Adsay V; Vaitkevicius V K; Al-Katib A M; Sarkar F H
Clonal preservation of human pancreatic cell line derived from primary pancreatic adenocarcinoma.
Pancreas 1999;19(4):353-61.
1999: Détivaud L; Pettit G R; Meijer L
Characterization of a novel cdk1-related kinase.
European journal of biochemistry / FEBS 1999;264(1):55-66.
1999: Ovechkina Y Y; Pettit R K; Cichacz Z A; Pettit G R; Oakley B R
Unusual antimicrotubule activity of the antifungal agent spongistatin 1.
Antimicrobial agents and chemotherapy 1999;43(8):1993-9.
1999: Mohammad R M; Limvarapuss C; Wall N R; Hamdy N; Beck F W; Pettit G R; Al-Katib A
A new tubulin polymerization inhibitor, auristatin PE, induces tumor regression in a human Waldenstrom's macroglobulinemia xenograft model.
International journal of oncology 1999;15(2):367-72.
1999: Pettit G R; Tan R; Melody N; Kielty J M; Pettit R K; Herald D L; Tucker B E; Mallavia L P; Doubek D L; Schmidt J M
Antineoplastic agents. Part 409: Isolation and structure of montanastatin from a terrestrial actinomycete.
Bioorganic & medicinal chemistry 1999;7(5):895-9.
1999: Pinney K G; Bounds A D; Dingeman K M; Mocharla V P; Pettit G R; Bai R; Hamel E
A new anti-tubulin agent containing the benzo[b]thiophene ring system.
Bioorganic & medicinal chemistry letters 1999;9(8):1081-6.
1999: Pettit G R; Toki B E; Herald D L; Boyd M R; Hamel E; Pettit R K; Chapuis J C
Antineoplastic agents. 410. Asymmetric hydroxylation of trans-combretastatin A-4.
Journal of medicinal chemistry 1999;42(8):1459-65.
1999: Pettit G R; Rhodes M R; Tan R
Antineoplastic agents. 400. Synthesis of the Indian Ocean marine sponge cyclic heptapeptide phakellistatin 2.
Journal of natural products 1999;62(3):409-14.
1999: Zhao S; Moore J V; Waller M L; McGown A T; Hadfield J A; Pettit G R; Hastings D L
Positron emission tomography of murine liver metastases and the effects of treatment by combretastatin A-4.
European journal of nuclear medicine 1999;26(3):231-8.
1999: Bodily J M; Hoopes D J; Roeder B L; Gilbert S G; Pettit G R; Herald C L; Rollins D N; Robison R A
The inhibitory effects of bryostatin 1 administration on the growth of rabbit papillomas.
Cancer letters 1999;136(1):67-74.
1999: Chaplin D J; Pettit G R; Hill S A
Anti-vascular approaches to solid tumour therapy: evaluation of combretastatin A4 phosphate.
Anticancer research 1999;19(1A):189-95.
1999: Kalemkerian G P; Ou X; Adil M R; Rosati R; Khoulani M M; Madan S K; Pettit G R
Activity of dolastatin 10 against small-cell lung cancer in vitro and in vivo: induction of apoptosis and bcl-2 modification.
Cancer chemotherapy and pharmacology 1999;43(6):507-15.
1998: Pettit G R; Rhodes M R; Herald D L; Chaplin D J; Stratford M R; Hamel E; Pettit R K; Chapuis J C; Oliva D
Antineoplastic agents 393. Synthesis of the trans-isomer of combretastatin A-4 prodrug.
Anti-cancer drug design 1998;13(8):981-93.
1998: Pettit R K; Pettit G R; Hazen K C
Specific activities of dolastatin 10 and peptide derivatives against Cryptococcus neoformans.
Antimicrobial agents and chemotherapy 1998;42(11):2961-5.
1998: Pettit G R; Tan R; Melody N; Cichacz Z A; Herald D L; Hoard M S; Pettit R K; Chapuis J C
Antineoplastic agents. 397: Isolation and structure of sesterstatins 4 and 5 from Hyrtios erecta (the Republic of Maldives).
Bioorganic & medicinal chemistry letters 1998;8(16):2093-8.
1998: Kamano Y; Kotake A; Hashima H; Inoue M; Morita H; Takeya K; Itokawa H; Nandachi N; Segawa T; Yukita A; Saitou K; Katsuyama M; Pettit G R
Structure-cytotoxic activity relationship for the toad poison bufadienolides.
Bioorganic & medicinal chemistry 1998;6(7):1103-15.
1998: Pettit G R; Tan R; Xu J; Ichihara Y; Williams M D; Boyd M R
Antineoplastic agents. 398. Isolation and structure elucidation of cephalostatins 18 and 19.
Journal of natural products 1998;61(7):955-8.
1998: Pettit G R; Srirangam J K; Barkoczy J; Williams M D; Boyd M R; Hamel E; Pettit R K; Hogan F; Bai R; Chapuis J C; McAllister S C; Schmidt J M
Antineoplastic agents 365. Dolastatin 10 SAR probes.
Anti-cancer drug design 1998;13(4):243-77.
1998: Wender P A; DeBrabander J; Harran P G; Jimenez J M; Koehler M F; Lippa B; Park C M; Siedenbiedel C; Pettit G R
The design, computer modeling, solution structure, and biological evaluation of synthetic analogs of bryostatin 1.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(12):6624-9.
1998: Khan P; McGown A T; Dawson M J; Jayson G; Prendiville J A; Pettit G R; Crowther D
High-performance liquid chromatographic assay for the novel antitumor drug, bryostatin-1, incorporating a serum extraction technique.
Journal of chromatography. B, Biomedical sciences and applications 1998;709(1):113-7.
1998: Mohammad R M; Varterasian M L; Almatchy V P; Hannoudi G N; Pettit G R; Al-Katib A
Successful treatment of human chronic lymphocytic leukemia xenografts with combination biological agents auristatin PE and bryostatin 1.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(5):1337-43.
1998: Al-Katib A M; Smith M R; Kamanda W S; Pettit G R; Hamdan M; Mohamed A N; Chelladurai B; Mohammad R M
Bryostatin 1 down-regulates mdr1 and potentiates vincristine cytotoxicity in diffuse large cell lymphoma xenografts.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(5):1305-14.
1998: Pettit G R; Toki B; Herald D L; Verdier-Pinard P; Boyd M R; Hamel E; Pettit R K
Antineoplastic agents. 379. Synthesis of phenstatin phosphate.
Journal of medicinal chemistry 1998;41(10):1688-95.
1998: Pettit G R; Rhodes M R
Antineoplastic agents 389. New syntheses of the combretastatin A-4 prodrug.
Anti-cancer drug design 1998;13(3):183-91.
1998: Mohammad R M; Al-Katib A; Pettit G R; Vaitkevicius V K; Joshi U; Adsay V; Majumdar A P; Sarkar F H
An orthotopic model of human pancreatic cancer in severe combined immunodeficient mice: potential application for preclinical studies.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(4):887-94.
1998: Smith A B; Lin Q; Pettit G R; Chapuis J C; Schmidt J M
Synthesis and in vitro cancer cell growth inhibitory activity of monocyclic model compounds containing spongistatin triene side-chains.
Bioorganic & medicinal chemistry letters 1998;8(6):567-8.
1998: Ali M A; Rosati R; Pettit G R; Kalemkerian G P
Dolastatin 15 induces apoptosis and BCL-2 phosphorylation in small cell lung cancer cell lines.
Anticancer research 1998;18(2A):1021-6.
1998: Mohammad R M; Pettit G R; Almatchy V P; Wall N; Varterasian M; Al-Katib A
Synergistic interaction of selected marine animal anticancer drugs against human diffuse large cell lymphoma.
Anti-cancer drugs 1998;9(2):149-56.
1998: Turner T; Jackson W H; Pettit G R; Wells A; Kraft A S
Treatment of human prostate cancer cells with dolastatin 10, a peptide isolated from a marine shell-less mollusc.
The Prostate 1998;34(3):175-81.
1998: Pettit G R; Flahive E J; Boyd M R; Bai R; Hamel E; Pettit R K; Schmidt J M
Antineoplastic agents 360. Synthesis and cancer cell growth inhibitory studies of dolastatin 15 structural modifications.
Anti-cancer drug design 1998;13(1):47-66.
1998: Pettit G R; Cichacz A; Tan R; Hoard M S; Melody N; Pettit R
Antineoplastic agents. 386. Isolation of sesterstatins 1-3 from the marine sponge Hyrtios erecta.
Journal of natural products 1998;61(1):13-6.
1998: Varterasian M L; Mohammad R M; Eilender D S; Hulburd K; Rodriguez D H; Pemberton P A; Pluda J M; Dan M D; Pettit G R; Chen B D; Al-Katib A M
Phase I study of bryostatin 1 in patients with relapsed non-Hodgkin's lymphoma and chronic lymphocytic leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1998;16(1):56-62.
1998: McGown A T; Jayson G; Pettit G R; Haran M S; Ward T H; Crowther D
Bryostatin 1-tamoxifen combinations show synergistic effects on the inhibition of growth of P388 cells in vitro.
British journal of cancer 1998;77(2):216-20.
1997: Lorenzo P S; Bögi K; Acs P; Pettit G R; Blumberg P M
The catalytic domain of protein kinase Cdelta confers protection from down-regulation induced by bryostatin 1.
The Journal of biological chemistry 1997;272(52):33338-43.
1997: Pettit G R; Xu J P; Hogan F; Williams M D; Doubek D L; Schmidt J M; Cerny R L; Boyd M R
Isolation and structure of the human cancer cell growth inhibitory cyclodepsipeptide dolastatin 16.
Journal of natural products 1997;60(8):752-4.
1997: Matthews S A; Pettit G R; Rozengurt E
Bryostatin 1 induces biphasic activation of protein kinase D in intact cells.
The Journal of biological chemistry 1997;272(32):20245-50.
1997: Dark G G; Hill S A; Prise V E; Tozer G M; Pettit G R; Chaplin D J
Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculature.
Cancer research 1997;57(10):1829-34.
1997: Lee H W; Smith L; Pettit G R; Smith J B
Bryostatin 1 and phorbol ester down-modulate protein kinase C-alpha and -epsilon via the ubiquitin/proteasome pathway in human fibroblasts.
Molecular pharmacology 1997;51(3):439-47.
1997: Pettit G R; McNulty J; Herald D L; Doubek D L; Chapuis J C; Schmidt J M; Tackett L P; Boyd M R
Antineoplastic agents. 362. Isolation and X-ray crystal structure of dibromophakellstatin from the Indian ocean sponge Phakellia mauritiana.
Journal of natural products 1997;60(2):180-3.
1997: Pettit R K; McAllister S C; Pettit G R; Herald C L; Johnson J M; Cichacz Z A
A broad-spectrum antifungal from the marine sponge Hyrtios erecta.
International journal of antimicrobial agents 1997;9(3):147-52.
1997: Pettit G R
The dolastatins.
Fortschritte der Chemie organischer Naturstoffe. Progress in the chemistry of organic natural products. Progrès dans la chimie des substances organiques naturelles 1997;70():1-79.
1996: Pettit G R; Butler M S; Williams M D; Filiatrault M J; Pettit R K
Isolation and structure of hemibastadinols 1-3 from the Papua New Guinea marine sponge Ianthella basta.
Journal of natural products 1996;59(10):927-34.
1996: Bai R; Schwartz R E; Kepler J A; Pettit G R; Hamel E
Characterization of the interaction of cryptophycin 1 with tubulin: binding in the Vinca domain, competitive inhibition of dolastatin 10 binding, and an unusual aggregation reaction.
Cancer research 1996;56(19):4398-406.
1996: McBain J A; Eastman A; Simmons D L; Pettit G R; Mueller G C
Phorbol ester augments butyrate-induced apoptosis of colon cancer cells.
International journal of cancer. Journal international du cancer 1996;67(5):715-23.
1996: Pettit G R; Hoard M S; Doubek D L; Schmidt J M; Pettit R K; Tackett L P; Chapuis J C
Antineoplastic agents 338. The cancer cell growth inhibitory. Constituents of Terminalia arjuna (Combretaceae).
Journal of ethnopharmacology 1996;53(2):57-63.
1996: Pettit G R
Progress in the discovery of biosynthetic anticancer drugs.
Journal of natural products 1996;59(8):812-21.
1996: Lee H W; Smith L; Pettit G R; Vinitsky A; Smith J B
Ubiquitination of protein kinase C-alpha and degradation by the proteasome.
The Journal of biological chemistry 1996;271(35):20973-6.
1996: Chaplin D J; Pettit G R; Parkins C S; Hill S A
Antivascular approaches to solid tumour therapy: evaluation of tubulin binding agents.
The British journal of cancer. Supplement 1996;27():S86-8.
1996: Lee H W; Smith L; Pettit G R; Bingham Smith J
Dephosphorylation of activated protein kinase C contributes to downregulation by bryostatin.
The American journal of physiology 1996;271(1 Pt 1):C304-11.
1996: Maki A; Mohammad R; Raza S; Saleh M; Govindaraju K D; Pettit G R; al-Katib A
Effect of dolastatin 10 on human non-Hodgkin's lymphoma cell lines.
Anti-cancer drugs 1996;7(3):344-50.
1996: Carey J O; Posekany K J; deVente J E; Pettit G R; Ways D K
Phorbol ester-stimulated phosphorylation of PU.1: association with leukemic cell growth inhibition.
Blood 1996;87(10):4316-24.
1996: Szallasi Z; Du L; Levine R; Lewin N E; Nguyen P N; Williams M D; Pettit G R; Blumberg P M
The bryostatins inhibit growth of B16/F10 melanoma cells in vitro through a protein kinase C-independent mechanism: dissociation of activities using 26-epi-bryostatin 1.
Cancer research 1996;56(9):2105-11.
1996: Fodstad O; Breistøl K; Pettit G R; Shoemaker R H; Boyd M R
Comparative antitumor activities of halichondrins and vinblastine against human tumor xenografts.
Journal of experimental therapeutics & oncology 1996;1(2):119-25.
1996: Pettit G R; Gao F; Blumberg P M; Herald C L; Coll J C; Kamano Y; Lewin N E; Schmidt J M; Chapuis J C
Antineoplastic agents. 340. Isolation and structural elucidation of bryostatins 16-18.
Journal of natural products 1996;59(3):286-9.
1996: Zhang X; Zhang R; Zhao H; Cai H; Gush K A; Kerr R G; Pettit G R; Kraft A S
Preclinical pharmacology of the natural product anticancer agent bryostatin 1, an activator of protein kinase C.
Cancer research 1996;56(4):802-8.
1996: Mohammad R M; Maki A; Pettit G R; al-Katib A M
Bryostatin 1 induces ubiquitin COOH-terminal hydrolase in acute lymphoblastic leukemia cells.
Enzyme & protein 1996;49(5-6):262-72.
1996: Dorr R T; Dvorakova K; Snead K; Alberts D S; Salmon S E; Pettit G R
Antitumor activity of combretastatin-A4 phosphate, a natural product tubulin inhibitor.
Investigational new drugs 1996;14(2):131-7.
1996: Aherne G W; Hardcastle A; Valenti M; Bryant A; Rogers P; Pettit G R; Srirangam J K; Kelland L R
Antitumour evaluation of dolastatins 10 and 15 and their measurement in plasma by radioimmunoassay.
Cancer chemotherapy and pharmacology 1996;38(3):225-32.
1996: Kraft A S; Woodley S; Pettit G R; Gao F; Coll J C; Wagner F
Comparison of the antitumor activity of bryostatins 1, 5, and 8.
Cancer chemotherapy and pharmacology 1996;37(3):271-8.
1995: Kamano Y; Zhang H P; Hino A; Yoshida M; Pettit G R; Herald C L; Itokawa H
An improved source of bryostatin 10, Bugula neritina from the Gulf of Aomori, Japan.
Journal of natural products 1995;58(12):1868-75.
1995: Pettit G R; Srirangam J K; Barkoczy J; Williams M D; Durkin K P; Boyd M R; Bai R; Hamel E; Schmidt J M; Chapuis J C
Antineoplastic agents 337. Synthesis of dolastatin 10 structural modifications.
Anti-cancer drug design 1995;10(7):529-44.
1995: Mohammad R M; Diwakaran H; Maki A; Emara M A; Pettit G R; Redman B; al-Katib A
Bryostatin 1 induces apoptosis and augments inhibitory effects of vincristine in human diffuse large cell lymphoma.
Leukemia research 1995;19(9):667-73.
1995: Bai R; Taylor G F; Cichacz Z A; Herald C L; Kepler J A; Pettit G R; Hamel E
The spongistatins, potently cytotoxic inhibitors of tubulin polymerization, bind in a distinct region of the vinca domain.
Biochemistry 1995;34(30):9714-21.
1995: Pettit G R; Temple C; Narayanan V L; Varma R; Simpson M J; Boyd M R; Rener G A; Bansal N
Antineoplastic agents 322. synthesis of combretastatin A-4 prodrugs.
Anti-cancer drug design 1995;10(4):299-309.
1995: Pettit G R; Tan R; Ichihara Y; Williams M D; Doubek D L; Tackett L P; Schmidt J M; Cerny R L; Boyd M R; Hooper J N
Antineoplastic agents, 325. Isolation and structure of the human cancer cell growth inhibitory cyclic octapeptides phakellistatin 10 and 11 from Phakellia sp.
Journal of natural products 1995;58(6):961-5.
1995: Maki A; Diwakaran H; Redman B; al-Asfar S; Pettit G R; Mohammad R M; al-Katib A
The bcl-2 and p53 oncoproteins can be modulated by bryostatin 1 and dolastatins in human diffuse large cell lymphoma.
Anti-cancer drugs 1995;6(3):392-7.
1995: Pettit G R; Singh S B; Boyd M R; Hamel E; Pettit R K; Schmidt J M; Hogan F
Antineoplastic agents. 291. Isolation and synthesis of combretastatins A-4, A-5, and A-6(1a)
Journal of medicinal chemistry 1995;38(10):1666-72.
1995: Bai R; Taylor G F; Schmidt J M; Williams M D; Kepler J A; Pettit G R; Hamel E
Interaction of dolastatin 10 with tubulin: induction of aggregation and binding and dissociation reactions.
Molecular pharmacology 1995;47(5):965-76.
1995: Pettit G R; Pettit G R; Groszek G; Backhaus R A; Doubek D L; Barr R J; Meerow A W
Antineoplastic agents, 301. An investigation of the Amaryllidaceae genus Hymenocallis.
Journal of natural products 1995;58(5):756-9.
1995: Pettit G R; Pettit G R; Groszek G; Backhaus R A; Doubek D L; Barr R J; Meerow A W
Antineoplastic agents, 301. An investigation of the Amaryllidaceae genus Hymenocallis.
Journal of natural products 1995;58(5):756-9.
1995: Pettit G R; Butler M S; Bass C G; Doubek D L; Williams M D; Schmidt J M; Pettit R K; Hooper J N; Tackett L P; Filiatrault M J
Antineoplastic agents, 326. The stereochemistry of bastadins 8, 10, and 12 from the Bismarck archipelago marine sponge Ianthella basta.
Journal of natural products 1995;58(5):680-8.
1995: Pettit G R; Freeman S; Simpson M J; Thompson M A; Boyd M R; Williams M D; Pettit G R; Doubek D L
Antineoplastic agents 320: synthesis of a practical pancratistatin prodrug.
Anti-cancer drug design 1995;10(3):243-50.
1995: Pettit G R; Freeman S; Simpson M J; Thompson M A; Boyd M R; Williams M D; Pettit G R; Doubek D L
Antineoplastic agents 320: synthesis of a practical pancratistatin prodrug.
Anti-cancer drug design 1995;10(3):243-50.
1995: Woods J A; Hadfield J A; Pettit G R; Fox B W; McGown A T
The interaction with tubulin of a series of stilbenes based on combretastatin A-4.
British journal of cancer 1995;71(4):705-11.
1995: Patella V; Casolaro V; Ciccarelli A; Pettit G R; Columbo M; Marone G
The antineoplastic bryostatins affect human basophils and mast cells differently.
Blood 1995;85(5):1272-81.
1995: Pettit G R; Pettit G R; Backhaus R A; Boettner F E
Antineoplastic agents, 294. Variations in the formation of pancratistatin and related isocarbostyrils in Hymenocallis littoralis.
Journal of natural products 1995;58(1):37-43.
1995: Pettit G R; Pettit G R; Backhaus R A; Boettner F E
Antineoplastic agents, 294. Variations in the formation of pancratistatin and related isocarbostyrils in Hymenocallis littoralis.
Journal of natural products 1995;58(1):37-43.
1994: Szallasi Z; Denning M F; Smith C B; Dlugosz A A; Yuspa S H; Pettit G R; Blumberg P M
Bryostatin 1 protects protein kinase C-delta from down-regulation in mouse keratinocytes in parallel with its inhibition of phorbol ester-induced differentiation.
Molecular pharmacology 1994;46(5):840-50.
1994: Scheid C; Prendiville J; Jayson G; Crowther D; Fox B; Pettit G R; Stern P L
Immunomodulation in patients receiving intravenous Bryostatin 1 in a phase I clinical study: comparison with effects of Bryostatin 1 on lymphocyte function in vitro.
Cancer immunology, immunotherapy : CII 1994;39(4):223-30.
1994: Prendiville J; McGown A T; Gescher A; Dickson A J; Courage C; Pettit G R; Crowther D; Fox B W
Establishment of a murine leukaemia cell line resistant to the growth-inhibitory effect of bryostatin 1.
British journal of cancer 1994;70(4):573-8.
1994: Kazanietz M G; Lewin N E; Gao F; Pettit G R; Blumberg P M
Binding of [26-3H]bryostatin 1 and analogs to calcium-dependent and calcium-independent protein kinase C isozymes.
Molecular pharmacology 1994;46(2):374-9.
1994: Pettit G R; Gao F; Cerny R L; Doubek D L; Tackett L P; Schmidt J M; Chapuis J C
Antineoplastic agents. 278. Isolation and structure of axinastatins 2 and 3 from a western Caroline Island marine sponge.
Journal of medicinal chemistry 1994;37(8):1165-8.
1994: Kazanietz M G; Bustelo X R; Barbacid M; Kolch W; Mischak H; Wong G; Pettit G R; Bruns J D; Blumberg P M
Zinc finger domains and phorbol ester pharmacophore. Analysis of binding to mutated form of protein kinase C zeta and the vav and c-raf proto-oncogene products.
The Journal of biological chemistry 1994;269(15):11590-4.
1994: Jarvis W D; Povirk L F; Turner A J; Traylor R S; Gewirtz D A; Pettit G R; Grant S
Effects of bryostatin 1 and other pharmacological activators of protein kinase C on 1-[beta-D-arabinofuranosyl]cytosine-induced apoptosis in HL-60 human promyelocytic leukemia cells.
Biochemical pharmacology 1994;47(5):839-52.
1994: Grant S; Traylor R; Pettit G R; Lin P S
The macrocyclic lactone protein kinase C activator, bryostatin 1, either alone, or in conjunction with recombinant murine granulocyte-macrophage colony-stimulating factor, protects Balb/c and C3H/HeN mice from the lethal in vivo effects of ionizing radiation.
Blood 1994;83(3):663-7.
1994: Stanwell C; Gescher A; Bradshaw T D; Pettit G R
The role of protein kinase C isoenzymes in the growth inhibition caused by bryostatin 1 in human A549 lung and MCF-7 breast carcinoma cells.
International journal of cancer. Journal international du cancer 1994;56(4):585-92.
1994: Szallasi Z; Smith C B; Pettit G R; Blumberg P M
Differential regulation of protein kinase C isozymes by bryostatin 1 and phorbol 12-myristate 13-acetate in NIH 3T3 fibroblasts.
The Journal of biological chemistry 1994;269(3):2118-24.
1994: Mohammad R M; al-Katib A; Pettit G R; Sensenbrenner L L
Successful treatment of human Waldenström's macroglobulinemia with combination biological and chemotherapy agents.
Cancer research 1994;54(1):165-8.
1994: Pettit G R; Xu J P; Williams M D; Christie N D; Doubek D L; Schmidt J M; Boyd M R
Isolation and structure of cephalostatins 10 and 11.
Journal of natural products 1994;57(1):52-63.
1993: Pettit G R; Kantoci D; Doubek D L; Tucker B E; Pettit W E; Schroll R M
Isolation of the nickel-chlorin chelate tunichlorin from the South Pacific ocean sea hare Dolabella auricularia.
Journal of natural products 1993;56(11):1981-4.
1993: Philip P A; Rea D; Thavasu P; Carmichael J; Stuart N S; Rockett H; Talbot D C; Ganesan T; Pettit G R; Balkwill F
Phase I study of bryostatin 1: assessment of interleukin 6 and tumor necrosis factor alpha induction in vivo. The Cancer Research Campaign Phase I Committee.
Journal of the National Cancer Institute 1993;85(22):1812-8.
1993: Pettit G R; Pettit G R; Backhaus R A; Boyd M R; Meerow A W
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
Journal of natural products 1993;56(10):1682-7.
1993: Pettit G R; Pettit G R; Backhaus R A; Boyd M R; Meerow A W
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
Journal of natural products 1993;56(10):1682-7.
1993: Bai R; Cichacz Z A; Herald C L; Pettit G R; Hamel E
Spongistatin 1, a highly cytotoxic, sponge-derived, marine natural product that inhibits mitosis, microtubule assembly, and the binding of vinblastine to tubulin.
Molecular pharmacology 1993;44(4):757-66.
1993: Grant S; Traylor R; Pettit G R; Lin P S
Modulation by bryostatin 1 of the in vitro radioprotective effects of the GM-CSF/IL-3 fusion protein, PIXY 321, on normal human myeloid progenitors.
Cytokine 1993;5(5):490-7.
1993: al-Katib A; Mohammad R M; Khan K; Dan M E; Pettit G R; Sensenbrenner L L
Bryostatin 1-induced modulation of the acute lymphoblastic leukemia cell line Reh.
Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy 1993;14(1):33-42.
1993: McCrady C W; Li F; Pettit G R; Grant S
Modulation of the activity of a human granulocyte-macrophage colony-stimulating factor/interleukin-3 fusion protein (pIXY 321) by the macrocyclic lactone protein kinase C activator bryostatin 1.
Experimental hematology 1993;21(7):893-900.
1993: Berkow R L; Schlabach L; Dodson R; Benjamin W H; Pettit G R; Rustagi P; Kraft A S
In vivo administration of the anticancer agent bryostatin 1 activates platelets and neutrophils and modulates protein kinase C activity.
Cancer research 1993;53(12):2810-5.
1993: Hu Z B; Gignac S M; Quentmeier H; Pettit G R; Drexler H G
Effects of dolastatins on human B-lymphocytic leukemia cell lines.
Leukemia research 1993;17(4):333-9.
1993: Bai R; Roach M C; Jayaram S K; Barkoczy J; Pettit G R; Ludueña R F; Hamel E
Differential effects of active isomers, segments, and analogs of dolastatin 10 on ligand interactions with tubulin. Correlation with cytotoxicity.
Biochemical pharmacology 1993;45(7):1503-15.
1993: Pettit G R; Cichacz Z; Barkoczy J; Dorsaz A C; Herald D L; Williams M D; Doubek D L; Schmidt J M; Tackett L P; Brune D C
Isolation and structure of the marine sponge cell growth inhibitory cyclic peptide phakellistatin 1.
Journal of natural products 1993;56(2):260-7.
1993: el-Zayat A A; Degen D; Drabek S; Clark G M; Pettit G R; Von Hoff D D
In vitro evaluation of the antineoplastic activity of combretastatin A-4, a natural product from Combretum caffrum (arid shrub).
Anti-cancer drugs 1993;4(1):19-25.
1993: Isakov N; Galron D; Mustelin T; Pettit G R; Altman A
Inhibition of phorbol ester-induced T cell proliferation by bryostatin is associated with rapid degradation of protein kinase C.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(4):1195-204.
1993: Ludueña R F; Roach M C; Prasad V; Pettit G R
Interaction of halichondrin B and homohalichondrin B with bovine brain tubulin.
Biochemical pharmacology 1993;45(2):421-7.
1993: Mohammad R M; al-Katib A; Pettit G R; Sensenbrenner L L
Differential effects of bryostatin 1 on human non-Hodgkin's B-lymphoma cell lines.
Leukemia research 1993;17(1):1-8.
1993: al-Katib A; Mohammad R M; Dan M; Hussein M E; Akhtar A; Pettit G R; Sensenbrenner L L
Bryostatin 1-induced hairy cell features on chronic lymphocytic leukemia cells in vitro.
Experimental hematology 1993;21(1):61-5.
1993: Stewart J P; McGown A T; Prendiville J; Pettit G R; Fox B W; Arrand J R
Bryostatin 1 induces productive Epstein-Barr virus replication in latently infected cells: implications for use in immunocompromised patients.
Cancer chemotherapy and pharmacology 1993;33(1):89-91.
1992: Grant S; Jarvis W D; Turner A J; Wallace H J; Pettit G R
Effects of bryostatin 1 and rGM-CSF on the metabolism of 1-beta-D-arabinofuranosylcytosine in human leukaemic myeloblasts.
British journal of haematology 1992;82(3):522-8.
1992: Grant S; Jarvis W D; Swerdlow P S; Turner A J; Traylor R S; Wallace H J; Lin P S; Pettit G R; Gewirtz D A
Potentiation of the activity of 1-beta-D-arabinofuranosylcytosine by the protein kinase C activator bryostatin 1 in HL-60 cells: association with enhanced fragmentation of mature DNA.
Cancer research 1992;52(22):6270-8.
1992: Li F; Grant S; Pettit G R; McCrady C W
Bryostatin 1 modulates the proliferation and lineage commitment of human myeloid progenitor cells exposed to recombinant interleukin-3 and recombinant granulocyte-macrophage colony-stimulating factor.
Blood 1992;80(10):2495-502.
1992: Gabrielsen B; Monath T P; Huggins J W; Kefauver D F; Pettit G R; Groszek G; Hollingshead M; Kirsi J J; Shannon W M; Schubert E M
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
Journal of natural products 1992;55(11):1569-81.
1992: Steube K G; Grunicke D; Pietsch T; Gignac S M; Pettit G R; Drexler H G
Dolastatin 10 and dolastatin 15: effects of two natural peptides on growth and differentiation of leukemia cells.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1992;6(10):1048-53.
1992: Watters D J; Michael J; Hemphill J E; Hamilton S E; Lavin M F; Pettit G R
Bistratene A: a novel compound causing changes in protein phosphorylation patterns in human leukemia cells.
Journal of cellular biochemistry 1992;49(4):417-24.
1992: Kane C J; Long R; Petitt W E; Breneman G L; Pettit G R
Structure of bis(2-chloroethyl)ammonium hexachlorostannate.
Acta crystallographica. Section C, Crystal structure communications 1992;48 ( Pt 8)():1490-1.
1992: Bai R; Friedman S J; Pettit G R; Hamel E
Dolastatin 15, a potent antimitotic depsipeptide derived from Dolabella auricularia. Interaction with tubulin and effects of cellular microtubules.
Biochemical pharmacology 1992;43(12):2637-45.
1992: Tuttle T M; Bethke K P; Inge T H; McCrady C W; Pettit G R; Bear H D
Bryostatin 1-activated T cells can traffic and mediate tumor regression.
The Journal of surgical research 1992;52(6):543-8.
1992: Lewin N E; Dell'Aquila M L; Pettit G R; Blumberg P M; Warren B S
Binding of [3H]bryostatin 4 to protein kinase C.
Biochemical pharmacology 1992;43(9):2007-14.
1992: Grant S; Traylor R; Bhalla K; McCrady C; Pettit G R
Effect of a combined exposure to cytosine arabinoside, bryostatin 1, and recombinant granulocyte-macrophage colony-stimulating factor on the clonogenic growth in vitro of normal and leukemic human hematopoietic progenitor cells.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1992;6(5):432-9.
1992: Pettit G R; Sengupta D; Blumberg P M; Lewin N E; Schmidt J M; Kraft A S
Structural modifications of bryostatin 2.
Anti-cancer drug design 1992;7(2):101-14.
1992: Bradshaw T D; Gescher A; Pettit G R
Modulation by staurosporine of phorbol-ester-induced effects on growth and protein kinase C localization in A549 human lung-carcinoma cells.
International journal of cancer. Journal international du cancer 1992;51(1):144-8.
1992: Kraft A S; Adler V; Hall P; Pettit G R; Benjamin W H; Briles D E
In vivo administration of bryostatin 1, a protein kinase C activator, decreases murine resistance to Salmonella typhimurium.
Cancer research 1992;52(8):2143-7.
1992: Tuttle T M; Inge T H; Bethke K P; McCrady C W; Pettit G R; Bear H D
Activation and growth of murine tumor-specific T-cells which have in vivo activity with bryostatin 1.
Cancer research 1992;52(3):548-53.
1992: Ludueña R F; Roach M C; Prasad V; Pettit G R
Interaction of dolastatin 10 with bovine brain tubulin.
Biochemical pharmacology 1992;43(3):539-43.
1992: Grant S; Pettit G R; McCrady C
Effect of bryostatin 1 on the in vitro radioprotective capacity of recombinant granulocyte-macrophage colony-stimulating factor (rGM-CSF) toward committed human myeloid progenitor cells (CFU-GM).
Experimental hematology 1992;20(1):34-42.
1991: Pettit G R; Herald C L; Boyd M R; Leet J E; Dufresne C; Doubek D L; Schmidt J M; Cerny R L; Hooper J N; Rützler K C
Isolation and structure of the cell growth inhibitory constituents from the western Pacific marine sponge Axinella sp.
Journal of medicinal chemistry 1991;34(11):3339-40.
1991: Pettit G R; Doubek D L; Herald D L; Numata A; Takahasi C; Fujiki R; Miyamoto T
Isolation and structure of cytostatic steroidal saponins from the African medicinal plant Balanites aegyptica.
Journal of natural products 1991;54(6):1491-502.
1991: Bai R L; Paull K D; Herald C L; Malspeis L; Pettit G R; Hamel E
Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data.
The Journal of biological chemistry 1991;266(24):15882-9.
1991: Grant S; Boise L; Westin E; Howe C; Pettit G R; Turner A; McCrady C
In vitro effects of bryostatin 1 on the metabolism and cytotoxicity of 1-beta-D-arabinofuranosylcytosine in human leukemia cells.
Biochemical pharmacology 1991;42(4):853-67.
1991: Kiss Z; Rapp U R; Pettit G R; Anderson W B
Phorbol ester and bryostatin differentially regulate the hydrolysis of phosphatidylethanolamine in Ha-ras- and raf-oncogene-transformed NIH 3T3 cells.
The Biochemical journal 1991;276 ( Pt 2)():505-9.
1991: Mackanos E A; Pettit G R; Ramsdell J S
Bryostatins selectively regulate protein kinase C-mediated effects on GH4 cell proliferation.
The Journal of biological chemistry 1991;266(17):11205-12.
1991: Grant S; Pettit G R; Howe C; McCrady C
Effect of the protein kinase C activating agent bryostatin 1 on the clonogenic response of leukemic blast progenitors to recombinant granulocyte-macrophage colony-stimulating factor.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1991;5(5):392-8.
1991: Lilly M; Brown C; Pettit G; Kraft A
Bryostatin 1: a potential anti-leukemic agent for chronic myelomonocytic leukemia.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1991;5(4):283-7.
1991: Bradshaw T D; Gescher A; Pettit G R
The effect of fetal calf serum on growth arrest caused by activators of protein kinase C.
International journal of cancer. Journal international du cancer 1991;47(6):929-32.
1991: Lewin N E; Pettit G R; Kamano Y; Blumberg P M
Binding of [26-3H]-epi-bryostatin 4 to protein kinase C.
Cancer communications 1991;3(3):67-70.
1991: Zwelling L A; Chan D; Altschuler E; Mayes J; Hinds J; Pettit G R
Effect of bryostatin 1 on drug-induced, topoisomerase II-mediated DNA cleavage and topoisomerase II gene expression in human leukemia cells.
Biochemical pharmacology 1991;41(5):829-32.
1991: McCrady C W; Staniswalis J; Pettit G R; Howe C; Grant S
Effect of pharmacologic manipulation of protein kinase C by phorbol dibutyrate and bryostatin 1 on the clonogenic response of human granulocyte-macrophage progenitors to recombinant GM-CSF.
British journal of haematology 1991;77(1):5-15.
1991: Kiss Z; Chattopadhyay J; Pettit G R
Stimulation of phosphatidylcholine synthesis by activators of protein kinase C is dissociable from increased phospholipid hydrolysis.
The Biochemical journal 1991;273(Pt 1)():189-94.
1991: Schuchter L M; Esa A H; May S; Laulis M K; Pettit G R; Hess A D
Successful treatment of murine melanoma with bryostatin 1.
Cancer research 1991;51(2):682-7.
1991: Pettit G R
The bryostatins.
Fortschritte der Chemie organischer Naturstoffe. Progress in the chemistry of organic natural products. Progrès dans la chimie des substances organiques naturelles 1991;57():153-195.
1990: Pettit G R; Singh S B; Hogan F; Burkett D D
Chiral modifications of dolastatin 10: the potent cytostatic peptide (19aR)-isodolastatin 10.
Journal of medicinal chemistry 1990;33(12):3132-3.
1990: Pettit G R; Schaufelberger D E; Nieman R A; Dufresne C; Saenz-Renauld J A
Antineoplastic agents, 177. Isolation and structure of phyllanthostatin 6.
Journal of natural products 1990;53(6):1406-13.
1990: Bai R L; Pettit G R; Hamel E
Structure-activity studies with chiral isomers and with segments of the antimitotic marine peptide dolastatin 10.
Biochemical pharmacology 1990;40(8):1859-64.
1990: Bai R L; Pettit G R; Hamel E
Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites.
The Journal of biological chemistry 1990;265(28):17141-9.
1990: Tuinman A A; Pettit G R
Analysis of the amino acid sequence of peptides by mass spectrometry. An ion notation proposal.
International journal of peptide and protein research 1990;36(4):331-4.
1990: Lilly M; Tompkins C; Brown C; Pettit G; Kraft A
Differentiation and growth modulation of chronic myelogenous leukemia cells by bryostatin.
Cancer research 1990;50(17):5520-5.
1990: Singh S B; Pettit G R
Antineoplastic agents, 195. Isolation and structure of aceratioside from Aceratium megalospermum.
Journal of natural products 1990;53(5):1187-92.
1990: Hennings H; Robinson V A; Michael D M; Pettit G R; Jung R; Yuspa S H
Development of an in vitro analogue of initiated mouse epidermis to study tumor promoters and antipromoters.
Cancer research 1990;50(15):4794-800.
1990: Bai R; Pettit G R; Hamel E
Dolastatin 10, a powerful cytostatic peptide derived from a marine animal. Inhibition of tubulin polymerization mediated through the vinca alkaloid binding domain.
Biochemical pharmacology 1990;39(12):1941-9.
1990: Jalava A M; Heikkilä J; Akerlind G; Pettit G R; Akerman K E
Effects of bryostatins 1 and 2 on morphological and functional differentiation of SH-SY5Y human neuroblastoma cells.
Cancer research 1990;50(11):3422-8.
1990: McBain J A; Pettit G R; Mueller G C
Phorbol esters activate proteoglycan metabolism in human colon cancer cells en route to terminal differentiation.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1990;1(6):281-91.
1990: Gignac S M; Buschie M; Pettit G R; Hoffbrand A V; Drexler H G
Expression of proto-oncogene c-jun during differentiation of B-chronic lymphocytic leukemia.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1990;4(6):441-4.
1990: Cirillo R; Triggiani M; Siri L; Ciccarelli A; Pettit G R; Condorelli M; Marone G
Cyclosporin A rapidly inhibits mediator release from human basophils presumably by interacting with cyclophilin.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(10):3891-7.
1990: Pettit G R; Numata A; Takemura T; Ode R H; Narula A S; Schmidt J M; Cragg G M; Pase C P
Antineoplastic agents, 107. Isolation of acteoside and isoacteoside from Castilleja linariaefolia.
Journal of natural products 1990;53(2):456-8.
1990: Pettit G R; Herald D L; Cragg G M; Rideout J A; Brown P
Antineoplastic agents, 178. Isolation and structure of lychnostatins 1 and 2 from the South American Lychnophora antillana.
Journal of natural products 1990;53(2):382-90.
1990: al-Katib A; Mohammad R M; Mohamed A N; Pettit G R; Sensenbrenner L L
Conversion of high grade lymphoma tumor cell line to intermediate grade with TPA and bryostatin 1 as determined by polypeptide analysis on 2D gel electrophoresis.
Hematological oncology 1990;8(2):81-9.
1990: Pettit G R; Cragg G M; Singh S B; Duke J A; Doubek D L
Antineoplastic agents, 162. Zephyranthes candida.
Journal of natural products 1990;53(1):176-8.
1990: Columbo M; Galeone D; Guidi G; Kagey-Sobotka A; Lichtenstein L M; Pettit G R; Marone G
Modulation of mediator release from human basophils and pulmonary mast cells and macrophages by auranofin.
Biochemical pharmacology 1990;39(2):285-91.
1990: Drexler H G; Gignac S M; Pettit G R; Hoffbrand A V
Synergistic action of calcium ionophore A23187 and protein kinase C activator bryostatin 1 on human B cell activation and proliferation.
European journal of immunology 1990;20(1):119-27.
1990: Pettit G R; Rideout J A; Hasler J A
Isolation of geodiatoxins 2-4 from the marine sponge Geodia mesotriaena.
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology 1990;96(2):305-6.
1989: Drexler H G; Gignac S M; Jones R A; Scott C S; Pettit G R; Hoffbrand A V
Bryostatin 1 induces differentiation of B-chronic lymphocytic leukemia cells.
Blood 1989;74(5):1747-57.
1989: Lin C M; Ho H H; Pettit G R; Hamel E
Antimitotic natural products combretastatin A-4 and combretastatin A-2: studies on the mechanism of their inhibition of the binding of colchicine to tubulin.
Biochemistry 1989;28(17):6984-91.
1989: Jetten A M; George M A; Pettit G R; Rearick J I
Effects of bryostatins and retinoic acid on phorbol ester- and diacylglycerol-induced squamous differentiation in human tracheobronchial epithelial cells.
Cancer research 1989;49(14):3990-5.
1989: Jetten A M; George M A; Pettit G R; Herald C L; Rearick J I
Action of phorbol esters, bryostatins, and retinoic acid on cholesterol sulfate synthesis: relation to the multistep process of differentiation in human epidermal keratinocytes.
The Journal of investigative dermatology 1989;93(1):108-15.
1989: Dale I L; Bradshaw T D; Gescher A; Pettit G R
Comparison of effects of bryostatins 1 and 2 and 12-O-tetradecanoylphorbol-13-acetate on protein kinase C activity in A549 human lung carcinoma cells.
Cancer research 1989;49(12):3242-5.
1989: Baer J C; Slack J A; Pettit G R
Stability-indicating high-performance liquid chromatography assay for the anticancer drug bryostatin 1.
Journal of chromatography 1989;467(1):332-5.
1989: Kraft A S; William F; Pettit G R; Lilly M B
Varied differentiation responses of human leukemias to bryostatin 1.
Cancer research 1989;49(5):1287-93.
1989: Pettit G R; Singh S B; Hamel E; Lin C M; Alberts D S; Garcia-Kendall D
Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4.
Experientia 1989;45(2):209-11.
1989: Blumberg P M; Pettit G R; Warren B S; Szallasi A; Schuman L D; Sharkey N A; Nakakuma H; Dell'Aquila M L; de Vries D J
The protein kinase C pathway in tumor promotion.
Progress in clinical and biological research 1989;298():201-12.
1988: Hess A D; Silanskis M K; Esa A H; Pettit G R; May W S
Activation of human T lymphocytes by bryostatin.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(10):3263-9.
1988: Leonard J P; May W S; Ihle J N; Pettit G R; Sharkis S J
Regulation of hematopoiesis-IV: The role of interleukin-3 and bryostatin 1 in the growth of erythropoietic progenitors from normal and anemic W/Wv mice.
Blood 1988;72(5):1492-6.
1988: Pettit G R; Schaufelberger D E
Isolation and structure of the cytostatic lignan glycoside phyllanthostatin A.
Journal of natural products 1988;51(6):1104-12.
1988: de Vries D J; Herald C L; Pettit G R; Blumberg P M
Demonstration of sub-nanomolar affinity of bryostatin 1 for the phorbol ester receptor in rat brain.
Biochemical pharmacology 1988;37(21):4069-73.
1988: Warren B S; Kamano Y; Pettit G R; Blumberg P M
Mimicry of bryostatin 1 induced phosphorylation patterns in HL-60 cells by high-phorbol ester concentrations.
Cancer research 1988;48(21):5984-8.
1988: Wender P A; Cribbs C M; Koehler K F; Sharkey N A; Herald C L; Kamano Y; Pettit G R; Blumberg P M
Modeling of the bryostatins to the phorbol ester pharmacophore on protein kinase C.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(19):7197-201.
1988: Lin C M; Singh S B; Chu P S; Dempcy R O; Schmidt J M; Pettit G R; Hamel E
Interactions of tubulin with potent natural and synthetic analogs of the antimitotic agent combretastatin: a structure-activity study.
Molecular pharmacology 1988;34(2):200-8.
1988: Parker J; Waite M; Pettit G R; Daniel L W
Stimulation of arachidonic acid release and prostaglandin synthesis by bryostatin 1.
Carcinogenesis 1988;9(8):1471-4.
1988: Dell'Aquila M L; Herald C L; Kamano Y; Pettit G R; Blumberg P M
Differential effects of bryostatins and phorbol esters on arachidonic acid metabolite release and epidermal growth factor binding in C3H 10T1/2 cells.
Cancer research 1988;48(13):3702-8.
1988: Stone R M; Sariban E; Pettit G R; Kufe D W
Bryostatin 1 activates protein kinase C and induces monocytic differentiation of HL-60 cells.
Blood 1988;72(1):208-13.
1988: Fields A P; Pettit G R; May W S
Phosphorylation of lamin B at the nuclear membrane by activated protein kinase C.
The Journal of biological chemistry 1988;263(17):8253-60.
1988: Pettit G R; Singh S B; Schmidt J M; Niven M L; Hamel E; Lin C M
Isolation, structure, synthesis, and antimitotic properties of combretastatins B-3 and B-4 from Combretum caffrum.
Journal of natural products 1988;51(3):517-27.
1988: Gschwendt M; Fürstenberger G; Rose-John S; Rogers M; Kittstein W; Pettit G R; Herald C L; Marks F
Bryostatin 1, an activator of protein kinase C, mimics as well as inhibits biological effects of the phorbol ester TPA in vivo and in vitro.
Carcinogenesis 1988;9(4):555-62.
1988: Pasti G; Rivedal E; Yuspa S H; Herald C L; Pettit G R; Blumberg P M
Contrasting duration of inhibition of cell-cell communication in primary mouse epidermal cells by phorbol 12,13-dibutyrate and by bryostatin 1.
Cancer research 1988;48(2):447-51.
1988: McBain J A; Pettit G R; Mueller G C
Bryostatin 1 antagonizes the terminal differentiating action of 12-O-tetradecanoylphorbol-13-acetate in a human colon cancer cell.
Carcinogenesis 1988;9(1):123-9.
1988: Trenn G; Pettit G R; Takayama H; Hu-Li J; Sitkovsky M V
Immunomodulating properties of a novel series of protein kinase C activators. The bryostatins.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(2):433-9.
1988: Kamano Y; Satoh N; Nakayoshi H; Pettit G R; Smith C R
Rhinovirus inhibition by bufadienolides.
Chemical & pharmaceutical bulletin 1988;36(1):326-32.
1988: Warren J T; Esa A H; Pettit G R; May W S
Bryostatin stimulation of human neutrophil luminol and DBA (lucigenin) chemiluminescence.
Basic life sciences 1988;49():223-7.
1987: May W S; Sharkis S J; Esa A H; Gebbia V; Kraft A S; Pettit G R; Sensenbrenner L L
Antineoplastic bryostatins are multipotential stimulators of human hematopoietic progenitor cells.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(23):8483-7.
1987: Dell'Aquila M L; Nguyen H T; Herald C L; Pettit G R; Blumberg P M
Inhibition by bryostatin 1 of the phorbol ester-induced blockage of differentiation in hexamethylene bisacetamide-treated Friend erythroleukemia cells.
Cancer research 1987;47(22):6006-9.
1987: Mohr H; Pettit G R; Plessing-Menze A
Co-induction of lymphokine synthesis by the antineoplastic bryostatins.
Immunobiology 1987;175(5):420-30.
1987: Garrison J C; Pettit G R; Uyeki E M
Effect of phorbol and bryostatin I on chondrogenic expression of chick limb bud, in vitro.
Life sciences 1987;41(17):2055-61.
1987: Sako T; Yuspa S H; Herald C L; Pettit G R; Blumberg P M
Partial parallelism and partial blockade by bryostatin 1 of effects of phorbol ester tumor promoters on primary mouse epidermal cells.
Cancer research 1987;47(20):5445-50.
1987: Hennings H; Blumberg P M; Pettit G R; Herald C L; Shores R; Yuspa S H
Bryostatin 1, an activator of protein kinase C, inhibits tumor promotion by phorbol esters in SENCAR mouse skin.
Carcinogenesis 1987;8(9):1343-6.
1987: Kiss Z; Deli E; Girard P R; Pettit G R; Kuo J F
Comparative effects of polymyxin B, phorbol ester and bryostatin on protein phosphorylation, protein kinase C translocation, phospholipid metabolism and differentiation of HL60 cells.
Biochemical and biophysical research communications 1987;146(1):208-15.
1987: Pettit G R; Cragg G M; Singh S B
Antineoplastic agents, 122. Constituents of Combretum caffrum.
Journal of natural products 1987;50(3):386-91.
1987: Pettit G R; Cragg G M; Holzapfel C W; Tuinman A A; Gieschen D P
Solution-phase secondary-ion mass spectrometry of protonated amino acids.
Analytical biochemistry 1987;162(1):236-41.
1987: Kiss Z; Deli E; Shoji M; Koeffler H P; Pettit G R; Vogler W R; Kuo J F
Differential effects of various protein kinase C activators on protein phosphorylation in human acute myeloblastic leukemia cell line KG-1 and its phorbol ester-resistant subline KG-1a.
Cancer research 1987;47(5):1302-7.
1987: Pettit G R; Singh S B; Niven M L; Hamel E; Schmidt J M
Isolation, structure, and synthesis of combretastatins A-1 and B-1, potent new inhibitors of microtubule assembly, derived from Combretum caffrum.
Journal of natural products 1987;50(1):119-31.
1986: Ramsdell J S; Pettit G R; Tashjian A H
Three activators of protein kinase C, bryostatins, dioleins, and phorbol esters, show differing specificities of action on GH4 pituitary cells.
The Journal of biological chemistry 1986;261(36):17073-80.
1986: Pettit G R; Gaddamidi V; Herald D L; Singh S B; Cragg G M; Schmidt J M; Boettner F E; Williams M; Sagawa Y
Antineoplastic agents, 120. Pancratium littorale.
Journal of natural products 1986;49(6):995-1002.
1986: Pettit G R; Kamano Y; Herald C L
Antineoplastic agents, 118. Isolation and structure of bryostatin 9.
Journal of natural products 1986;49(4):661-4.
1986: Pettit G R; Herald D L; Herald C L; Kokke W C; Djerassi C
The crystal structure of 3 beta-hydroxy-4 alpha, 23R, 24R-trimethyl-5 alpha-cholestane (23R, 24R-5 alpha-dinostanol) from dinoflagellates.
Steroids 1986;47(4-5):321-6.
1986: Pettit G R; Leet J E; Herald C L; Kamano Y; Doubek D L
Antineoplastic agents, 116. An evaluation of the marine ascidian Aplidium californicum.
Journal of natural products 1986;49(2):231-5.
1985: Smith J B; Smith L; Pettit G R
Bryostatins: potent, new mitogens that mimic phorbol ester tumor promoters.
Biochemical and biophysical research communications 1985;132(3):939-45.
1985: Piatak D M; Patel J; Totten C E; Swenson R P; Brown P; Pettit G R
Cell growth inhibitory glycosides from Asclepias amplexicaulis.
Journal of natural products 1985;48(3):470-1.
1984: Pettit G R; Gaddamidi V; Cragg G M
Antineoplastic agents, 105. Zephyranthes grandiflora.
Journal of natural products 1984;47(6):1018-20.
1984: Pettit G R; Goswami A; Cragg G M; Schmidt J M; Zou J C
Antineoplastic agents, 103. The isolation and structure of hypoestestatins 1 and 2 from the East African Hypoëstes verticillaris.
Journal of natural products 1984;47(6):913-9.
1984: Pettit G R; Gaddamidi V; Goswami A; Cragg G M
Antineoplastic agents, 99. Amaryllis belladonna.
Journal of natural products 1984;47(5):796-801.
1983: Pettit G R; Zou J C; Goswami A; Cragg G M; Schmidt J M
Antineoplastic agents, 88. Pimelea prostrata.
Journal of natural products 1983;46(4):563-8.
1983: Pettit G R; Barton D H; Herald C L; Polonsky J; Schmidt J M; Connolly J D
Evaluation of limonoids against the murine P388 lymphocytic leukemia cell line.
Journal of natural products 1983;46(3):379-90.
1982: Pettit G R; Fujii Y; Hasler J A; Schmidt J M
Isolation and characterization of palystatins A-D.
Journal of natural products 1982;45(3):272-6.
1981: Pettit G R; Hasler J A; Paull K D; Herald C L
Antineoplastic agents. 76. The sea urchin Strongylocentrotus droebachiensis.
Journal of natural products 1981;44(6):701-4.
1981: Pettit G R; Rideout J A; Hasler J A
Isolation of geodiastatins 1 and 2 from the marine sponge Geodia mesotriaena.
Journal of natural products 1981;44(5):588-92.
1981: Pettit G R; Kamano Y; Fujii Y; Herald C L; Inoue M; Brown P; Gust D; Kitahara K; Schmidt J M; Doubek D L; Michel C
Marine animal biosynthetic constituents for cancer chemotherapy.
Journal of natural products 1981;44(4):482-5.
1980: Polonsky J; Varon Z; Moretti C; Pettit G R; Herald C L; Rideout J A; Saha S B; Khastgir H N
The antineoplastic quassinoids of Simaba cuspidata spruce and Ailanthus grandis Prain.
Journal of natural products 1980;43(4):503-9.
1979: Pettit G R; Gieschen D P; Pettit W E
Antineoplastic agents LXIV: 1,4-Bis(2'-chloroethyl)-1,4-diazabicyclo[2.2.1]heptane dihydrogen dimaleate.
Journal of pharmaceutical sciences 1979;68(12):1539-42.
1979: Polonsky J; Varon Z; Marazano C; Arnoux B; Pettit G R; Schmid J M; Ochi M; Kotsuki H
The structure of amoorastatone and the cytotoxic limonoid 12-hydroxyamoorastatin.
Experientia 1979;35(8):987-9.
1979: Pettit G R; Smith T H
Structural biochemistry XIII: Synthesis of luteinizing hormone-releasing hormone modification [Trp8]-LH-RH.
Journal of pharmaceutical sciences 1979;68(8):1013-5.
1979: Pettit G R; Krupa T S; Reynolds R M
Structural biochemistry. 17. Synthesis of tryptophan dipeptides.
International journal of peptide and protein research 1979;14(3):193-8.
1978: Polonsky J; Varon Z; Jacquemin H; Pettit G R
The isolation and structure of 13,18-dehydroglaucarubinone, a new antineoplastic quassinoid from Simarouba amara.
Experientia 1978;34(9):1122-3.
1978: Schmidt J M; Pettit G R
Presence of oncornavirus-like particles in the P388 murine leukemic cell line.
Experientia 1978;34(5):659-60.
1978: Pettit G R; Einck J J; Brown P
Structural biochemistry 15--mass spectrometry of permethylated nucleotides.
Biomedical mass spectrometry 1978;5(2):153-60.
1978: Pettit G R; Herald C L; Judd G F; Bolliger G; Vanell L D; Lehto E; Pase C P
Antineoplastic agents. 52. Baileya multiradiata.
Lloydia 1978;41(1):29-36.
1977: Pettit G R; Blazer R M; Reierson D A
Antineoplastic agents. 51. The yellow jacket Vespula pensylvanica.
Lloydia 1977;40(3):247-52.
1977: Pettit G R; Ode R H
Antineoplastic agents L: isolation and characterization of sphyrnastatins 1 and 2 from the hammerhead shark Sphyrna lewini.
Journal of pharmaceutical sciences 1977;66(5):757-8.
1977: Kamano Y; Pettit G R; Tozawa M; Yoshida S
Steroids and related natural products. 94 Synthesis of toad venom cardenolides.
The Journal of organic chemistry 1977;42(5):906-8.
1977: Pettit G R; Herald C L; Allen M S; von Dreele R B; Vanell L D; Kao J P; Blake W
The isolation and structure of aplysistatin.
Journal of the American Chemical Society 1977;99(1):262-3.
1976: Pettit G R; Herald C L; Herald D L
Antineoplastic agents XLV: sea cucumber cytotoxic saponins.
Journal of pharmaceutical sciences 1976;65(10):1558-9.
1976: Pettit G R; Von Dreele R B; Herald D L; Edgar M T; Wood H B
Structure of an antineoplastic agent from Streptomyces griseoluteus.
Journal of the American Chemical Society 1976;98(21):6742-3.
1976: Pettit G R; Ode R H; Coomes R M; Ode S L
Antineoplastic agents. 42. The butterfly, Prioneris thestylis.
Lloydia 1976;39(5):363-7.
1976: Pettit G R; Ode R H
Antineoplastic agents. 41. The beetle Allomyrina dichotomus.
Lloydia 1976;39(2-3):129-33.
1975: Pettit G R; Herald C L; Judd G F; Bolliger G; Thayer P S
Antineoplastic and cytotoxic components of desert Baileya.
Journal of pharmaceutical sciences 1975;64(12):2023-4.
1975: Pettit G R; Einck J J; Herald C L; Ode R H; Von Dreele R B; Brown P; Brazhnikova M G; Gause G F
Letter: The structure of carminomycin I.
Journal of the American Chemical Society 1975;97(25):7387-8.
1975: Von Dreele R B; Pettit G R; Ode R H; Perdue R E; White J D; Manchand P S
The crystal and molecular structure of the unusual spiro dihydrofuran diterpene nepetaefolin.
Journal of the American Chemical Society 1975;97(21):6236-40.
1975: Kamano Y; Pettit G R; Tozawa M; Komeichi Y; Inoue M
Bufadienolides. 30. Synthesis of the Ch'an Su component 15beta-hydroxybufalin.
The Journal of organic chemistry 1975;40(14):2136-8.
1975: Kamano Y; Tozawa M; Pettit G R
Steroids and related natural products. 90. 15beta-Hydroxydigitoxigenin.
The Journal of organic chemistry 1975;40(6):793-6.
1975: Kamano Y; Pettit G R; Tozawa M
Steroids and related natural products. Part XCII. Conversion of canarigenone (14-hydroxy-3-oxo-14beta-carda-4,20(22)-dienolide) into periplogenin (3beta,5,14-trihydroxy-5beta,14beta-card-20(22)-enolide).
Journal of the Chemical Society. Perkin transactions 1 1975;(19):1976-8.
1975: Kamano Y; Pettit G R; Tozawa M
Steroids and related natural products. Part XCI. Synthesis of the cardenolides canarigenin and uzarigenin.
Journal of the Chemical Society. Perkin transactions 1 1975;(19):1972-6.
1974: Kamano Y; Pettit G R; Inoue M
Bufadienolides. 29. Synthetic routes to bufotalin.
The Journal of organic chemistry 1974;39(20):3007-13.
1974: Pettit G R; Kamano Y
Bufadienolides. 28. Marinobufotoxin.
The Journal of organic chemistry 1974;39(20):3003-6.
1974: Pettit G R; Saldana E I; Lehto E
Antineoplastic agents 35. Rhus trilobata.
Lloydia 1974;37(3):539-40.
1974: Pettit G R; Budzinski J C; Cragg G M; Brown P; Johnston L D
Antineoplastic agents. 34. Helenium autumnale L.
Journal of medicinal chemistry 1974;17(9):1013-6.
1974: Pettit G R; Saldana E I
Antineoplastic agents. 36. Acetylenic carrier groups.
Journal of medicinal chemistry 1974;17(8):896-8.
1974: Pettit G R; Kamano Y
Bufadienolides. 27. Synthesis of telocinobufagin.
The Journal of organic chemistry 1974;39(17):2632-4.
1974: Kamano Y; Pettit G R
Bufadienolides. 26. Synthesis of scillarenin.
The Journal of organic chemistry 1974;39(17):2629-31.
1974: Kamano Y; Pettit G R; Tozawa M
Steroids and related natural products. 88. Synthesis of periplogenin.
The Journal of organic chemistry 1974;39(15):2319-20.
1973: Pettit G R; Ode R H; Harvey T B
Isolation of taurine from the molluscs Macrocallista nimbosa and Turbo stenogyrus.
Lloydia 1973;36(2):204-6.
1973: Pettit G R; Traxler P M; Pase C P
Antineoplastic agents 31. Oenothera caespitosa.
Lloydia 1973;36(2):202-3.
1973: Pettit G R; von Dreele R B; Bollinger G; Traxler P M; Brown P
Isolation and structural elucidation of 3,6-dioxo-hexahydro-pyrrolo (1,2-a)-pyrazine from the echinoderm Luidia clathrata.
Experientia 1973;29(5):521-2.
1973: Pettit G R; Kamano Y
Bufadienolides. 23. 14,15 -Epoxy-3 ,11 -dihydroxy-5 -bufa-20,22-dienolide (11 -hydroxyresibufogenin).
Journal of the Chemical Society. Perkin transactions 1 1973;7():725-7.
1973: Pettit G R; Gupta S K; Ode R H
Structural biochemisry. XII. Synthesis of tobacco mosaic virus protein unit 150-158.
Journal of the Chemical Society. Perkin transactions 1 1973;9():950-4.
1973: Pettit G R; Cragg G M
Antineoplastic agents. 32. The pseudoguaianolide helenalin.
Experientia 1973;29(7):781.
1972: Pettit G R; Kamano Y
Bufadienolides. 21. Synthesis of cinobufagin from bufotalin.
The Journal of organic chemistry 1972;37(25):4040-4.
1972: Kamano Y; Pettit G R
Transformation of digitoxigenin to scillarenin.
Journal of the American Chemical Society 1972;94(24):8592-3.
1972: Pettit G R; Quinn R J; Smith T H; Brown P
The camptothecin -lectone.
The Journal of organic chemistry 1972;37(17):2789-91.
1972: Kamano Y; Pettit G R
Synthesis of marinobufagin and marinobufotoxin from telecinobufagin.
Experientia 1972;28(7):768.
1972: Villaescusa F W; Pettit G R
Steroids and related natural products. 70. Conversion of cardenolides to isocardanolides.
Journal of medicinal chemistry 1972;15(7):781-3.
1972: Pettit G R; Houghton L E; Rogers N H; Coomes R M; Berger D F; Reucroft P R; Day J F; Hartwell J L; Wood H B
Butterfly wing antineoplastic agents.
Experientia 1972;28(4):381-2.
1972: Pettit G R; Dias J R
Steroids and related natural products. 66. Structural modification of the triterpene A ring.
The Journal of organic chemistry 1972;37(7):973-6.
1972: Brown P; Brüschweiler F; Pettit G R
[Mass spectrum studies of natural products; cardenolides]
Helvetica chimica acta 1972;55(2):531-43.
1972: Villaescusa F W; Pettit G R
Steroids and related natural products. 69. Synthesis of 20(22)-dihydro-23-deoxodigitoxigenin.
The Journal of organic chemistry 1972;37(4):569-72.
1971: Pettit G R; Kamano Y; Bruschweiler F; Brown P
Bufadienolides. 14. Synthesis of bufotalien, 15 -hydroxybufalin, and resibufogenin.
The Journal of organic chemistry 1971;36(24):3736-9.
1971: Fleming W C; Pettit G R
Synthesis of 2-dialkylamino-6- and -7-hydroxy-5,8-dioxoquinolines.
The Journal of organic chemistry 1971;36(23):3490-3.
1971: Abraham D J; Rosenstein R D; Pettit G R
Single crystal x-ray structures of chemotherapeutic agents. 3. Structure of 1,4-diazabicyclo[2.2.1]heptanes, a new heterocyclic ring system.
Journal of medicinal chemistry 1971;14(11):1141-2.
1971: Pettit G R; Dias J R
Bufadienolides. 13. Conversion of 3 beta-hydroxy-17-oxoandrost-5-ene to 3 beta-acetoxy-5 beta, 14 alpha-bufa-20,22-dienolide.
The Journal of organic chemistry 1971;36(21):3207-11.
1971: Pettit G R; Jones W R
Synthesis of tobacco mosaic virus protein sequence 81-85.
The Journal of organic chemistry 1971;36(7):870-3.
1970: Pettit G R; Kasturi T R
Steroids and related natural products. 63. 17-beta-acetoxy-4-oxa-2-androstene.
Journal of medicinal chemistry 1970;13(6):1244-5.
1970: Pettit G R; Houghton L E; Knight J C; Bruschweiler F
Bufadienolides. 11. Bufalin and resibufogenin.
The Journal of organic chemistry 1970;35(9):2895-8.
1970: Pettit G R; Day J F; Hartwell J L; Wood H B
Antineoplastic components of marine animals.
Nature 1970;227(5261):962-3.
1970: Pettit G R; Kasturi T R; Knight J C; Occolowitz J
Bufadienolides. 8. 12(13--14)abeo skeletal rearrangements.
The Journal of organic chemistry 1970;35(5):1404-10.
1970: Pettit G R; Green B; Dunn G L; Sunder-Plassmann P
Bufadienolides. 4. Reaction of 20-oxo steroids with methoxymethylenetriphenylphosphorane.
The Journal of organic chemistry 1970;35(5):1385-9.
1970: Knight J C; Pettit G R; Brown P
Bufadienolides. 10. 3-beta-acetoxy-14-beta,21-epoxy-5-beta-bufanolide and related lactones.
The Journal of organic chemistry 1970;35(5):1415-9.
1970: Pettit G R; Kasturi T R; Knight J C; Jaeggi K A
Bufadienolides. 9. Isobufalin.
The Journal of organic chemistry 1970;35(5):1410-4.
1970: Pettit G R; Knight J C; Herald C L
Bufadienolides. 6. Synthesis of 17-beta-(6'-alpha-pyronyl)androstanes.
The Journal of organic chemistry 1970;35(5):1393-8.
1970: Pettit G R; Herald C L; Yardley J P
Bufadienolides. 5. Synthesis of cardenolides.
The Journal of organic chemistry 1970;35(5):1389-92.
1970: Pettit G R; Green B; Das Gupta A K; Whitehouse P A; Yardley J P
Bufadienolides. 3. A synthetic route to isocardenolides.
The Journal of organic chemistry 1970;35(5):1381-4.
1970: Pettit G R; Green B; Dunn G L
Bufadienolides. 2. 20-hydroxy-21-nor-5-alpha-cholanic acid gamma-lactones (24--20).
The Journal of organic chemistry 1970;35(5):1377-80.
1970: Pettit G R; Green B; Dunn G L
Bufadienolides. 1. Introduction and base-catalyzed condensation of methyl ketones with glyoxylic acid.
The Journal of organic chemistry 1970;35(5):1367-76.
1970: Pettit G R; Fessler D C; Paull K D; Hofer P; Knight J C
Bufadienolides. 7. Synthesis of 3-beta-acetoxy-5-alpha,14-alpha-bufa-20,22-dienolide.
The Journal of organic chemistry 1970;35(5):1398-404.
1969: Fessler D C; Pettit G R; Settepani J A
Antineoplastic agents. XXV. 1,4-Diazabicyclo [2.2.1] heptanes.
Journal of medicinal chemistry 1969;12(3):542-3.
1968: Pettit G R; Hartwell J L; Wood H B
Arthropod antineoplastic agent.
Cancer research 1968;28(10):2168-9.
1968: Pettit G R; Houghton L E
Synthesis of 6-hydroxy-5,8-dioxo-7-(9-hydroxy-9'-n-pentyltetradecyl)carbostyril.
Journal of medicinal chemistry 1968;11(5):1080-2.
1968: Knight J C; Pettit G R
Oxidation of 3-beta-acetoxy-14-alpha-methyl-5-alpha-cholest-7-ene.
The Journal of organic chemistry 1968;33(4):1684-6.
1968: Pettit G R; Fleming W C; Paull K D
Synthesis of the 6- and 7-hydroxy-5,8-dioxocarbostyrils.
The Journal of organic chemistry 1968;33(3):1089-92.
1968: Pettit G R; Gupta S K
Structural biochemistry. 8. 9-Amino-(9-deoxy)-cinchona alkaloids.
Journal of the Chemical Society. Perkin transactions 1 1968;10():1208-13.
1967: Pettit G R; Gupta S K; Whitehouse P A
Antineoplastic agents. 18. N-(2-haloethyl)benzylamines.
Journal of medicinal chemistry 1967;10(4):692-6.
1967: Pettit G R; Smith R L; Klinger H
Synthesis of 3-beta-acetoxy-17-beta-(L-arginyl-L-arginyl-L-prolyl) amino-5-alpha-androstane.
Journal of medicinal chemistry 1967;10(2):145-8.
1967: Pettit G R; Brown T H
Steroids and related natural products. XLI. 14 alpha-Methyl Oestranes.
Journal of the Chemical Society. Perkin transactions 1 1967;20():2024-6.
1967: Knight J C; Belletire J L; Pettit G R
Steroids and related natural products. XLII. 14-alpha-methyl cholestanes.
Journal of the Chemical Society. Perkin transactions 1 1967;22():2427-32.
1966: Pettit G R; Yardley J P
Cardenolides.
Chemistry & industry 1966;13():553.
1964: Pettit G R; Das Gupta A K; Klinger H; Occolowitz J
Steroidal peptides.
Experientia 1964;20(10):545-6.
1964: Pettit G R; Green B; Das Gupta A K; Dunn G L
Isocardenolides.
Experientia 1964;20(5):248-9.
1963: PETTIT G R
Steroid stereochemistry.
Experientia 1963;19():124-5.
1962: MUELLER G P; PETTIT G R
Nomenclature of steroidal sapogenins.
Experientia 1962;18():404-5.
1962: PETTIT G R; BAUMANN M F; RANGAMMAL K N
ANTINEOPLASTIC AGENTS. V. THE AROMATIC SYSTEM OF PODOPHYLLOTOXIN (PART B).
Journal of medicinal and pharmaceutical chemistry 1962;91():800-8.
1962: PETTIT G R; SETTEPANI J A
ANTINEOPLASTIC AGENTS. IV. MANNICH BASE NITROGEN MUSTARDS (PART A).
Journal of medicinal and pharmaceutical chemistry 1962;51():296-302.

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