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Pavel Petukhov

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Chemicals & Drugs

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Publications

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Aditya Sudheer Vaidya; Richard B Van Breemen; Hazem Abdelkarim; He Bai; Sylvie Y Blond; Antonett Madriaga; Emma Mendonca; Raghupathi Neelarapu; Pavel A Petukhov
Novel histone deacetylase 8 ligands without a zinc chelating group: exploring an 'upside-down' binding pose.
Aditya Sudheer Vaidya; Richard B Van Breemen; Hazem Abdelkarim; Bhargava Karumudi; Antonett Madriaga; Emma Mendonca; Pavel A Petukhov
Design, synthesis, modeling, biological evaluation and photoaffinity labeling studies of novel series of photoreactive benzamide probes for histone deacetylase 2.
Michael Brunsteiner; Pavel A Petukhov
Insights from comprehensive multiple receptor docking to HDAC8.

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All Publications

2012: Aditya Sudheer Vaidya; Richard B Van Breemen; Hazem Abdelkarim; He Bai; Sylvie Y Blond; Antonett Madriaga; Emma Mendonca; Raghupathi Neelarapu; Pavel A Petukhov
Novel histone deacetylase 8 ligands without a zinc chelating group: exploring an 'upside-down' binding pose.
Bioorganic & medicinal chemistry letters 2012;22(21):6621-7.
2012: Aditya Sudheer Vaidya; Richard B Van Breemen; Hazem Abdelkarim; Bhargava Karumudi; Antonett Madriaga; Emma Mendonca; Pavel A Petukhov
Design, synthesis, modeling, biological evaluation and photoaffinity labeling studies of novel series of photoreactive benzamide probes for histone deacetylase 2.
Bioorganic & medicinal chemistry letters 2012;22(15):5025-30.
2012: Michael Brunsteiner; Pavel A Petukhov
Insights from comprehensive multiple receptor docking to HDAC8.
Journal of molecular modeling 2012;18(8):3927-39.
2011: Andrew B Nesterovitch; Pavel A Petukhov; M Simon; M D Tharp; M D Hoffman; T T Glant
Mutations in the PSTPIP1 gene and aberrant splicing variants in patients with pyoderma gangrenosum.
Clinical and experimental dermatology 2011;36(8):889-95.
2011: Raghupathi Neelarapu; Subash Velaparthi; He Bai; Sylvie Blond; Michael Brunsteiner; Denise L Holzle; Pavel A Petukhov
Design, synthesis, docking, and biological evaluation of novel diazide-containing isoxazole- and pyrazole-based histone deacetylase probes.
Journal of medicinal chemistry 2011;54(13):4350-64.
2011: Sergei M Danilov; Kerry Gordon; Sergey Kalinin; Heinrich Lünsdorf; Emma Mendonca; Richard D Minshall; Andrew B Nesterovitch; Pavel A Petukhov; Isolda A Popova; David E Schwartz; Maricela Castellon; Zhenlong Chen; Edward D Sturrock
An angiotensin I-converting enzyme mutation (Y465D) causes a dramatic increase in blood ACE via accelerated ACE shedding.
PloS one 2011;6(10):e25952.
2009: Bai He; Subash Velaparthi; Gilles Pieffet; Chris Pennington; Aruna Mahesh; Denise L Holzle; Michael Brunsteiner; Richard B Van Breemen; Sylvie Blond; Pavel A Petukhov
Binding ensemble profiling with photoaffinity labeling (BEProFL) approach: mapping the binding poses of HDAC8 inhibitors.
Journal of medicinal chemistry 2009;52(22):7003-13.
2009: Gilles Pieffet; Pavel A Petukhov
Parameterization of aromatic azido groups: application as photoaffinity probes in molecular dynamics studies.
Journal of molecular modeling 2009;15(11):1291-7.
2009: Srinivas Reddy Chirapu; Boobalan Pachaiyappan; Hikmet F Nural; Xin Cheng; Hongbin Yuan; David C Lankin; Samer Abdul-Hay; Gregory R J Thatcher; Yong Shen; Alan P Kozikowski; Pavel A Petukhov
Molecular modeling, synthesis, and activity studies of novel biaryl and fused-ring BACE1 inhibitors.
Bioorganic & medicinal chemistry letters 2009;19(1):264-74.
2008: Haq Zaheer-ul; Reaz Uddin; Hongbin Yuan; Pavel A Petukhov; M Iqbal Choudhary; Jeffry D Madura
Receptor-based modeling and 3D-QSAR for a quantitative production of the butyrylcholinesterase inhibitors based on genetic algorithm.
Journal of chemical information and modeling 2008;48(5):1092-103.
2008: Subash Velaparthi; Michael Brunsteiner; Reaz Uddin; Baojie Wan; Scott Franzblau; Pavel A Petukhov
5-tert-butyl-N-pyrazol-4-yl-4,5,6,7-tetrahydrobenzo[d]isoxazole-3-carboxamide derivatives as novel potent inhibitors of Mycobacterium tuberculosis pantothenate synthetase: initiating a quest for new antitubercular drugs.
Journal of medicinal chemistry 2008;51(7):1999-2002.
2008: Minsun Chang; Cassia R Overk; Irida Kastrati; Kuan-Wei Peng; Ping Yao; Zhihui Qin; Pavel A Petukhov; Judy L Bolton; Gregory R J Thatcher
Estrogenic activity of the equine estrogen metabolite, 4-methoxyequilenin.
Advances in experimental medicine and biology 2008;617():601-7.
2007: Joell J Gills; S Sianna Castillo; Chunyu Zhang; Pavel A Petukhov; Regan M Memmott; Melinda G Hollingshead; Noel A Warfel; Jiahuai Han; Alan P Kozikowski; Phillip A Dennis
Phosphatidylinositol ether lipid analogues that inhibit AKT also independently activate the stress kinase, p38alpha, through MKK3/6-independent and -dependent mechanisms.
The Journal of biological chemistry 2007;282(37):27020-9.
2007: Alan P Kozikowski; Sheela K Chellappan; Yingxian Xiao; Krishna Mohan Bajjuri; Hongbin Yuan; Kenneth J Kellar; Pavel A Petukhov
Chemical medicine: novel 10-substituted cytisine derivatives with increased selectivity for alpha4beta2 nicotinic acetylcholine receptors.
ChemMedChem 2007;2(8):1157-61.
2007: Alan P Kozikowski; Irina N Gaisina; Hongbin Yuan; Pavel A Petukhov; Sylvie Blond; Allison Fedolak; Barbara Caldarone; Paul McGonigle
Structure-based design leads to the identification of lithium mimetics that block mania-like effects in rodents. possible new GSK-3beta therapies for bipolar disorders.
Journal of the American Chemical Society 2007;129(26):8328-32.
2007: Zhihui Qin; Irida Kastrati; Ranepuradewage Chandrasena; Hong Liu; Ping Yao; Pavel A Petukhov; Judy L Bolton; Gregory R J Thatcher
Benzothiophene selective estrogen receptor modulators with modulated oxidative activity and receptor affinity.
Journal of medicinal chemistry 2007;50(11):2682-92.
2006: Hongbin Yuan; Pavel A Petukhov
Improved 3D-QSAR CoMFA of the dopamine transporter blockers with multiple conformations using the genetic algorithm.
Bioorganic & medicinal chemistry letters 2006;16(24):6267-72.
2006: Hongbin Yuan; Pavel A Petukhov
Computational evidence for the ligand selectivity to the alpha4beta2 and alpha3beta4 nicotinic acetylcholine receptors.
Bioorganic & medicinal chemistry 2006;14(23):7936-42.
2006: Alan P Kozikowski; Irina N Gaisina; Pavel A Petukhov; Jayalakshmi Sridhar; LaShaunda T King; Sylvie Blond; Tetyana Duka; Milan Rusnak; Anita Sidhu
Highly potent and specific GSK-3beta inhibitors that block tau phosphorylation and decrease alpha-synuclein protein expression in a cellular model of Parkinson's disease.
ChemMedChem 2006;1(2):256-66.
2005: Mira Jung; Alfredo Velena; Bin Chen; Pavel A Petukhov; Alan P Kozikowski; Anatoly Dritschilo
Novel HDAC inhibitors with radiosensitizing properties.
Radiation research 2005;163(5):488-93.
2005: Zhi-Liang Wei; Yingxian Xiao; Hongbin Yuan; Maryna Baydyuk; Pavel A Petukhov; John L Musachio; Kenneth J Kellar; Alan P Kozikowski
Novel pyridyl ring C5 substituted analogues of epibatidine and 3-(1-methyl-2(S)-pyrrolidinylmethoxy)pyridine (A-84543) as highly selective agents for neuronal nicotinic acetylcholine receptors containing beta2 subunits.
Journal of medicinal chemistry 2005;48(6):1721-4.
2005: Bin Chen; Pavel A Petukhov; Mira Jung; Alfredo Velena; Elena Eliseeva; Anatoly Dritschilo; Alan P Kozikowski
Chemistry and biology of mercaptoacetamides as novel histone deacetylase inhibitors.
Bioorganic & medicinal chemistry letters 2005;15(5):1389-92.
2004: Zhi-Liang Wei; Pavel A Petukhov; Fero Bizik; Joaquim Cabral Teixeira; Mark Mercola; Eugene A. Volpe; Robert I Glazer; Timothy M Willson; Alan P Kozikowski
Isoxazolyl-serine-based agonists of peroxisome proliferator-activated receptor: design, synthesis, and effects on cardiomyocyte differentiation.
Journal of the American Chemical Society 2004;126(51):16714-5.
2004: Hongbin Yuan; Alan P Kozikowski; Pavel A Petukhov
CoMFA study of piperidine analogues of cocaine at the dopamine transporter: exploring the binding mode of the 3 alpha-substituent of the piperidine ring using pharmacophore-based flexible alignment.
Journal of medicinal chemistry 2004;47(25):6137-43.
2004: Larry V Pearce; Pavel A Petukhov; Tamas Szabo; Noemi Kedei; Fero Bizik; Alan P Kozikowski; Peter M Blumberg
Evodiamine functions as an agonist for the vanilloid receptor TRPV1.
Organic & biomolecular chemistry 2004;2(16):2281-6.
2004: Pavel A Petukhov; Jianrong Zhang; Cheng Z Wang; Yan Ping Ye; Kenneth M Johnson; Alan P Kozikowski
Synthesis, molecular modeling, and biological studies of novel piperidine-based analogues of cocaine: evidence of unfavorable interactions proximal to the 3alpha-position of the piperidine ring.
Journal of medicinal chemistry 2004;47(12):3009-18.
2004: S Sianna Castillo; John Brognard; Pavel A Petukhov; Chunyu Zhang; Junji Tsurutani; Courtney A Granville; Min Li; Michael Jung; Kip A West; Joell G Gills; Alan P Kozikowski; Phillip A Dennis
Preferential inhibition of Akt and killing of Akt-dependent cancer cells by rationally designed phosphatidylinositol ether lipid analogues.
Cancer research 2004;64(8):2782-92.
2004: Alan P Kozikowski; Jiazhong Zhang; Fa-Jun Nan; Pavel A Petukhov; Ewa Grajkowska; Jarda T Wroblewski; Tatsuo Yamamoto; Tomasz Bzdega; Barbara Wroblewska; Joseph H Neale
Synthesis of urea-based inhibitors as active site probes of glutamate carboxypeptidase II: efficacy as analgesic agents.
Journal of medicinal chemistry 2004;47(7):1729-38.
2004: Quan Li; Changshu Jin; Pavel A Petukhov; Aleksey V Rukavishnikov; Tatiana O Zaikova; Avinash Phadke; Donald H LaMunyon; Melissa D Lee; John F W Keana
Synthesis of well-defined tower-shaped 1,3,5-trisubstituted adamantanes incorporating a macrocyclic trilactam ring system.
The Journal of organic chemistry 2004;69(4):1010-9.
2003: Quan Li; Aleksey V Rukavishnikov; Pavel A Petukhov; Tatiana O Zaikova; Changshu Jin; John F W Keana
Nanoscale tripodal 1,3,5,7-tetrasubstituted adamantanes for AFM applications.
The Journal of organic chemistry 2003;68(12):4862-9.
2003: Zhi-Liang Wei; Pavel A Petukhov; Yingxian Xiao; Werner Tückmantel; Clifford George; Kenneth J Kellar; Alan P Kozikowski
Synthesis, nicotinic acetylcholine receptor binding affinities, and molecular modeling of constrained epibatidine analogues.
Journal of medicinal chemistry 2003;46(6):921-4.
2003: Alan P Kozikowski; Ireneusz Nowak; Pavel A Petukhov; René Etcheberrigaray; Ali Mohamed; Mathew Tan; Nancy E Lewin; Henry Hennings; Larry L Pearce; Peter M Blumberg
New amide-bearing benzolactam-based protein kinase C modulators induce enhanced secretion of the amyloid precursor protein metabolite sAPPalpha.
Journal of medicinal chemistry 2003;46(3):364-73.
2002: Quan Li; Aleksey V Rukavishnikov; Pavel A Petukhov; Tatiana O Zaikova; John F W Keana
Nanoscale 1,3,5,7-tetrasubstituted adamantanes and p-substituted tetraphenyl-methanes for AFM applications.
Organic letters 2002;4(21):3631-4.
2002: William L Woolverton; Robert Ranaldi; Zhixia Wang; Gregory A Ordway; Ian A Paul; Pavel A Petukhov; Alan P Kozikowski
Reinforcing strength of a novel dopamine transporter ligand: pharmacodynamic and pharmacokinetic mechanisms.
The Journal of pharmacology and experimental therapeutics 2002;303(1):211-7.
2002: Pavel A Petukhov; Jianrong Zhang; Alan P Kozikowski; Cheng Z Wang; Yan Ping Ye; Kenneth M Johnson; Srihari R Tella
SAR studies of piperidine-based analogues of cocaine. 4. Effect of N-modification and ester replacement.
Journal of medicinal chemistry 2002;45(15):3161-70.
2002: Zhi-Liang Wei; Sukumar Sakamuri; Pavel A Petukhov; Clifford George; Nancy E Lewin; Peter M Blumberg; Alan P Kozikowski
Synthesis and modeling study of (2S,5R,6R)- and (2S,5R,6S)-6-hydroxy- 8-(1-decynyl)-benzolactam-V8 as protein kinase C modulators.
Organic letters 2002;4(13):2169-72.
2001: Pavel A Petukhov; Mei Zhang; K J Johnson; Srihari R Tella; Alan P Kozikowski
Sar studies of piperidine-based analogues of cocaine. Part 3: oxadiazoles.
Bioorganic & medicinal chemistry letters 2001;11(16):2079-83.