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John Pezzuto

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Martin Conda-Sheridan; Daniel E Beck; Lian Chen; Bingjie Hu; Trung X Nguyen; Eun-Jung Park; John M Pezzuto; P V Narasimha Reddy; Richard B Van Breemen; Jerry J White; Mark Cushman
Design, synthesis, and biological evaluation of indenoisoquinoline rexinoids with chemopreventive potential.
Brittany E Burns; Tamara P Kondratyuk; Laura E Marler; Bushra Mirza; Eun-Jung Park; John M Pezzuto
Preliminary evaluation for cancer chemopreventive and cytotoxic potential of naturally growing ethnobotanically selected plants of Pakistan.
Tamara P Kondratyuk; Bushra Mirza; Eun-Jung Park; John M Pezzuto; Charles J Simmons; Ui-Joung Youn; Robert P Borris; Xingyun Chai; Leng Chee Chang
Biologically active withanolides from Withania coagulans.

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All Publications

2013: Martin Conda-Sheridan; Daniel E Beck; Lian Chen; Bingjie Hu; Trung X Nguyen; Eun-Jung Park; John M Pezzuto; P V Narasimha Reddy; Richard B Van Breemen; Jerry J White; Mark Cushman
Design, synthesis, and biological evaluation of indenoisoquinoline rexinoids with chemopreventive potential.
Journal of medicinal chemistry 2013;56(6):2581-605.
2013: Brittany E Burns; Tamara P Kondratyuk; Laura E Marler; Bushra Mirza; Eun-Jung Park; John M Pezzuto
Preliminary evaluation for cancer chemopreventive and cytotoxic potential of naturally growing ethnobotanically selected plants of Pakistan.
Pharmaceutical biology 2013;51(3):316-28.
2013: Tamara P Kondratyuk; Bushra Mirza; Eun-Jung Park; John M Pezzuto; Charles J Simmons; Ui-Joung Youn; Robert P Borris; Xingyun Chai; Leng Chee Chang
Biologically active withanolides from Withania coagulans.
Journal of natural products 2013;76(1):22-8.
2013: Skylar Carlson; Laura Marler; Sang-Jip Nam; John M Pezzuto; Bernard D Santarsiero; Brian T Murphy
Potential Chemopreventive Activity of a New Macrolide Antibiotic from a Marine-Derived Micromonospora sp.
Marine drugs 2013;11(4):1152-61.
2012: Abdelrahman S Mayhoub; Eun-Jung Park; John M Pezzuto; Tamara P Kondratyuk; Laura Marler; Mark Cushman
Optimization of thiazole analogues of resveratrol for induction of NAD(P)H:quinone reductase 1 (QR1).
Bioorganic & medicinal chemistry 2012;20(24):7030-9.
2012: Xufen Yu; Tamara P Kondratyuk; Eun-Jung Park; John M Pezzuto; Dianqing Sun
Synthesis of 2-arylindole derivatives and evaluation as nitric oxide synthase and NFκB inhibitors.
Organic & biomolecular chemistry 2012;10(44):8835-47.
2012: Suaib Luqman; Laura E Marler; Abha Meena; John M Pezzuto; Pragya Singh; Tamara P Kondratyuk; Arvind S Negi
Neoflavonoids and tetrahydroquinolones as possible cancer chemopreventive agents.
Chemical biology & drug design 2012;80(4):616-24.
2012: Eun-Jung Park; John M Pezzuto
Flavonoids in cancer prevention.
Anti-cancer agents in medicinal chemistry 2012;12(8):836-51.
2012: Ui-Joung Youn; Robert P Borris; Tamara P Kondratyuk; Eun-Jung Park; John M Pezzuto; Charles J Simmons; Thanapat Songsak; Patcharawan Tanamatayarat; Onoomar Toyama; Supakit Wongwiwatthananukit; Leng Chee Chang
Anti-inflammatory sesquiterpene lactones from the flower of Vernonia cinerea.
Bioorganic & medicinal chemistry letters 2012;22(17):5559-62.
2012: Dianqing Sun; Mark Cushman; Julian G Hurdle; Robin Lee; Richard Lee; John M Pezzuto
Evaluation of flavonoid and resveratrol chemical libraries reveals abyssinone II as a promising antibacterial lead.
ChemMedChem 2012;7(9):1541-5.
2012: Crystal R Archer; Jérôme Clerc; Robert Dudler; Michael Groll; Markus Kaiser; Tamara P Kondratyuk; John M Pezzuto; Barbara Schellenberg; Martin L Stein; André S Bachmann
Activity enhancement of the synthetic syrbactin proteasome inhibitor hybrid and biological evaluation in tumor cells.
Biochemistry 2012;51(34):6880-8.
2012: Lian Chen; Martin Conda-Sheridan; Tamara P Kondratyuk; Andrew Morrell; Eun-Jung Park; John M Pezzuto; P V Narasimha Reddy; Richard B Van Breemen; Mark Cushman
Identification, synthesis, and biological evaluation of the metabolites of 3-amino-6-(3'-aminopropyl)-5H-indeno[1,2-c]isoquinoline-5,11-(6H)dione (AM6-36), a promising rexinoid lead compound for the development of cancer chemotherapeutic and chemopreventive agents.
Journal of medicinal chemistry 2012;55(12):5965-81.
2012: Eun-Jung Park; John M Pezzuto; Sergio A Bucarey; Kyoung Hwa Jang; Sang-Jip Nam; William Fenical
Suppression of nitric oxide synthase by thienodolin in lipopolysaccharide-stimulated RAW 264.7 murine macrophage cells.
Natural product communications 2012;7(6):789-94.
2012: Abdelrahman S Mayhoub; Eun-Jung Park; John M Pezzuto; Tamara P Kondratyuk; Laura Marler; Mark Cushman
Optimization of the aromatase inhibitory activities of pyridylthiazole analogues of resveratrol.
Bioorganic & medicinal chemistry 2012;20(7):2427-34.
2012: Eun-Jung Park; Martin Conda-Sheridan; Mark Cushman; Evgeny Kiselev; John M Pezzuto
Induction of apoptosis by 3-amino-6-(3-aminopropyl)-5,6-dihydro-5,11-dioxo-11H-indeno[1,2-c]isoquinoline via modulation of MAPKs (p38 and c-Jun N-terminal kinase) and c-Myc in HL-60 human leukemia cells.
Journal of natural products 2012;75(3):378-84.
2012: Tamara P Kondratyuk; Brian Thatcher Murphy; Eun-Jung Park; Ratnakar N Asolkar; William Fenical; Richard B Van Breemen; Rui Yu; John M Pezzuto
Novel marine phenazines as potential cancer chemopreventive and anti-inflammatory agents.
Marine drugs 2012;10(2):451-64.
2011: Li Shen; Anthony D Wright; Daniela Guendisch; Tamara P Kondratyuk; Laura Marler; Eun-Jung Park; John M Pezzuto; Dianqing Sun
Design, synthesis, and biological evaluation of callophycin A and analogues as potential chemopreventive and anticancer agents.
Bioorganic & medicinal chemistry 2011;19(21):6182-95.
2011: Suaib Luqman; Laura E Marler; Abha Meena; Tamara P Kondratyuk; John M Pezzuto
Suppression of tumor necrosis factor-α-induced nuclear factor κB activation and aromatase activity by capsaicin and its analog capsazepine.
Journal of medicinal food 2011;14(11):1344-51.
2011: Tamara P Kondratyuk; Laura E Marler; Andrew D Mesecar; Eun-Jung Park; Soyoun Ahn; Yongsoo Choi; Mark Cushman; Clinton J Grubbs; Juma Hoshino; Katherine C Jermihov; Bin Sun; Richard B Van Breemen; Rui Yu; Yang Yuan; John M Pezzuto
Resveratrol derivatives as promising chemopreventive agents with improved potency and selectivity.
Molecular nutrition & food research 2011;55(8):1249-65.
2011: Eun-Jung Park; Tamara P Kondratyuk; Andrew Morrell; Evgeny Kiselev; Martin Conda-Sheridan; Mark Cushman; Soyoun Ahn; Yongsoo Choi; Jerry J White; Richard B Van Breemen; John M Pezzuto
Induction of retinoid X receptor activity and consequent upregulation of p21WAF1/CIP1 by indenoisoquinolines in MCF7 cells.
Cancer prevention research (Philadelphia, Pa.) 2011;4(4):592-607.
2011: Juan Zou; Lutai Pan; Qiji Li; Junhua Zhao; Jianxin Pu; Ping Yao; Ningbo Gong; Yang Lu; Tamara P Kondratyuk; John M Pezzuto; Harry H S Fong; Hongjie Zhang; Handong Sun
Rubesanolides A and B: diterpenoids from Isodon rubescens.
Organic letters 2011;13(6):1406-9.
2011: Jian-Hong Yang; Tamara P Kondratyuk; Katherine C Jermihov; Laura E Marler; Xi Qiu; Yongsoo Choi; Hongmei Cao; Rui Yu; Megan Sturdy; Rong Huang; Ying Liu; Li-Qin Wang; Andrew D Mesecar; Richard B Van Breemen; John M Pezzuto; Harry H S Fong; Ye-Gao Chen; Hong-Jie Zhang
Bioactive compounds from the fern Lepisorus contortus.
Journal of natural products 2011;74(2):129-36.
2011: Yongsoo Choi; Katherine Jermihov; Sang-Jip Nam; Megan Sturdy; Katherine Maloney; Xi Qiu; Lucas R Chadwick; Matthew Main; Shaonong Chen; Andrew D Mesecar; Norman R Farnsworth; Guido F Pauli; William Fenical; John M Pezzuto; Richard B van Breemen; Richard B Van Breemen
Screening natural products for inhibitors of quinone reductase-2 using ultrafiltration LC-MS.
Analytical chemistry 2011;83(3):1048-52.
2011: Eun-Jung Park; Leng Chee Chang; Sarot Cheenpracha; Tamara P Kondratyuk; John M Pezzuto
Inhibition of lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric oxide synthase expression by 4-[(2'-O-acetyl-α-L-rhamnosyloxy)benzyl]isothiocyanate from Moringa oleifera.
Nutrition and cancer 2011;63(6):971-82.
2011: Ole Vang; Thomas Walle; Nihal Ahmad; Clifton A Baile; Joseph A Baur; Karen Brown; Anna Csiszar; Dipak K Das; Dominique Delmas; Carmem Gottfried; Hung-Yun Lin; Qing-Yong Ma; Partha Mukhopadhyay; Namasivayam Nalini; John M Pezzuto; Tristan Richard; Yogeshwer Shukla; Young-Joon Surh; Thomas Szekeres; Tomasz Szkudelski; Joseph M Wu
What is new for an old molecule? Systematic review and recommendations on the use of resveratrol.
PloS one 2011;6(6):e19881.
2011: John M Pezzuto
The phenomenon of resveratrol: redefining the virtues of promiscuity.
Annals of the New York Academy of Sciences 2011;1215():123-30.
2010: Martin Conda-Sheridan; Laura Marler; Eun-Jung Park; Tamara P Kondratyuk; Katherine Jermihov; Andrew D Mesecar; John M Pezzuto; Ratnakar N Asolkar; William Fenical; Mark Cushman
Potential chemopreventive agents based on the structure of the lead compound 2-bromo-1-hydroxyphenazine, isolated from Streptomyces species, strain CNS284.
Journal of medicinal chemistry 2010;53(24):8688-99.
2010: Laura Marler; Martin Conda-Sheridan; Maris A Cinelli; Andrew E Morrell; Mark Cushman; Lian Chen; Ke Huang; Richard B Van Breemen; John M Pezzuto
Cancer chemopreventive potential of aromathecins and phenazines, novel natural product derivatives.
Anticancer research 2010;30(12):4873-82.
2010: Mauro C C Morais; Suaib Luqman; Tamara P Kondratyuk; Maicon S Petronio; Luis O Regasini; Dulce Helena Siqueira Silva; Vanderlan S Bolzani; Christiane P Soares; John M Pezzuto
Suppression of TNF-α induced NFκB activity by gallic acid and its semi-synthetic esters: possible role in cancer chemoprevention.
Natural product research 2010;24(18):1758-65.
2010: Sarot Cheenpracha; Eun-Jung Park; Wesley Y Yoshida; Chaz Barit; Marisa Wall; John M Pezzuto; Leng Chee Chang
Potential anti-inflammatory phenolic glycosides from the medicinal plant Moringa oleifera fruits.
Bioorganic & medicinal chemistry 2010;18(17):6598-602.
2010: Bin Sun; Juma Hoshino; Katie Jermihov; Laura Marler; John M Pezzuto; Andrew D Mesecar; Mark Cushman
Design, synthesis, and biological evaluation of resveratrol analogues as aromatase and quinone reductase 2 inhibitors for chemoprevention of cancer.
Bioorganic & medicinal chemistry 2010;18(14):5352-66.
2010: Barbara Calamini; Kiira Ratia; Michael G Malkowski; Muriel Cuendet; John M Pezzuto; Bernard D Santarsiero; Andrew D Mesecar
Pleiotropic mechanisms facilitated by resveratrol and its metabolites.
The Biochemical journal 2010;429(2):273-82.
2010: Juma Hoshino; Eun-Jung Park; Tamara P Kondratyuk; Laura Marler; John M Pezzuto; Richard B Van Breemen; Shunyan Mo; Yongchao Li; Mark Cushman
Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites.
Journal of medicinal chemistry 2010;53(13):5033-43.
2010: Suaib Luqman; John M Pezzuto
NFkappaB: a promising target for natural products in cancer chemoprevention.
Phytotherapy research : PTR 2010;24(7):949-63.
2010: Sang-Jip Nam; Susana P Gaudêncio; Christopher A Kauffman; Paul R Jensen; Tamara P Kondratyuk; Laura E Marler; John M Pezzuto; William Fenical
Fijiolides A and B, inhibitors of TNF-alpha-induced NFkappaB activation, from a marine-derived sediment bacterium of the genus Nocardiopsis.
Journal of natural products 2010;73(6):1080-6.
2010: Norleena P Gullett; A R M Ruhul Amin; Soley Bayraktar; John M Pezzuto; Dong M Shin; Fadlo R Khuri; Bharat B Aggarwal; Young-Joon Surh; Omer Kucuk
Cancer prevention with natural compounds.
Seminars in oncology 2010;37(3):258-81.
2010: Denise C Endringer; Ydia M Valadares; Priscilla R V Campana; Jussara J Campos; Keller G Guimarães; John M Pezzuto; Fernão Castro Braga
Evaluation of Brazilian plants on cancer chemoprevention targets in vitro.
Phytotherapy research : PTR 2010;24(6):928-33.
2010: Jian-Hong Yang; Tamara P Kondratyuk; Laura E Marler; Xi Qiu; Yongsoo Choi; Hongmei Cao; Rui Yu; Megan Sturdy; Scott Pegan; Ying Liu; Li-Qin Wang; Andrew D Mesecar; Richard B Van Breemen; John M Pezzuto; Harry H S Fong; Ye-Gao Chen; Hong-Jie Zhang
Isolation and evaluation of kaempferol glycosides from the fern Neocheiropteris palmatopedata.
Phytochemistry 2010;71(5-6):641-7.
2010: Muriel Cuendet; Jian Guo; Yan Luo; Shaonong Chen; Carol P Oteham; Richard C Moon; Richard B Van Breemen; Laura E Marler; John M Pezzuto
Cancer chemopreventive activity and metabolism of isoliquiritigenin, a compound found in licorice.
Cancer prevention research (Philadelphia, Pa.) 2010;3(2):221-32.
2009: Peter Schupp; Claudia Kohlert-Schupp; Susanna Whitefield; Anna Engemann; Sven Rohde; Thomas Hemscheidt; John M Pezzuto; Tamara P Kondratyuk; Eun-Jung Park; Laura Marler; Bahman Rostama; Anthony D Wright
Cancer chemopreventive and anticancer evaluation of extracts and fractions from marine macro- and microorganisms collected from Twilight Zone waters around Guam.
Natural product communications 2009;4(12):1717-28.
2009: Denise C Endringer; John M Pezzuto; Fernão Castro Braga
NF-kappaB inhibitory activity of cyclitols isolated from Hancornia speciosa.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2009;16(11):1064-9.
2009: John M Pezzuto; Venkat Venkatasubramanian; Mazen Hamad; Kenneth R Morris
Unraveling the relationship between grapes and health.
The Journal of nutrition 2009;139(9):1783S-7S.
2009: Ye Deng; Marcy J Balunas; Jeong-Ah Kim; Daniel D Lantvit; Young-Won Chin; Heebyung Chai; Sugeng Sugiarso; Leonardus B S Kardono; Harry H S Fong; John M Pezzuto; Steven M Swanson; Esperanza J Carcache de Blanco; A Douglas Kinghorn
Bioactive 5,6-dihydro-alpha-pyrone derivatives from Hyptis brevipes.
Journal of natural products 2009;72(6):1165-9.
2009: Arup Maiti; P V Narasimha Reddy; Megan Sturdy; Laura Marler; Scott D Pegan; Andrew D Mesecar; John M Pezzuto; Mark Cushman
Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities.
Journal of medicinal chemistry 2009;52(7):1873-84.
2009: Qiuwen Mi; John M Pezzuto; Norman R Farnsworth; Mansukh C Wani; A Douglas Kinghorn; Steven M Swanson
Use of the in vivo hollow fiber assay in natural products anticancer drug discovery.
Journal of natural products 2009;72(3):573-80.
2009: Ratnakar N Asolkar; Kelle C Freel; Paul R Jensen; William Fenical; Tamara P Kondratyuk; Eun-Jung Park; John M Pezzuto
Arenamides A-C, cytotoxic NFkappaB inhibitors from the marine actinomycete Salinispora arenicola.
Journal of natural products 2009;72(3):396-402.
2009: Guangmin Yao; Tamara P Kondratyuk; Ghee T Tan; John M Pezzuto; Leng Chee Chang
Bioactive sulfated sesterterpene alkaloids and sesterterpene sulfates from the marine sponge Fasciospongia sp.
Journal of natural products 2009;72(2):319-23.
2009: Soo Sung Kang; Muriel Cuendet; Denise C Endringer; Vicki L Croy; John M Pezzuto; Mark A Lipton
Synthesis and biological evaluation of a library of resveratrol analogues as inhibitors of COX-1, COX-2 and NF-kappaB.
Bioorganic & medicinal chemistry 2009;17(3):1044-54.
2008: Muriel Cuendet; Carol P Oteham; Arup Maiti; Bruce A Craig; Mark Cushman; Richard C Moon; John M Pezzuto
Zapotin prevents mouse skin tumorigenesis during the stages of initiation and promotion.
Anticancer research 2008;28(6A):3705-9.
2008: Jian Guo; Ang Liu; Hongmei Cao; Yan Luo; John M Pezzuto; Richard B Van Breemen
Biotransformation of the chemopreventive agent 2',4',4-trihydroxychalcone (isoliquiritigenin) by UDP-glucuronosyltransferases.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(10):2104-12.
2008: Jacquelyn Francy-Guilford; John M Pezzuto
Mechanisms of cancer chemopreventive agents: a perspective.
Planta medica 2008;74(13):1644-50.
2008: Jacquelyn M Guilford; John M Pezzuto
Natural products as inhibitors of carcinogenesis.
Expert opinion on investigational drugs 2008;17(9):1341-52.
2008: John M Pezzuto
Grapes and human health: a perspective.
Journal of agricultural and food chemistry 2008;56(16):6777-84.
2008: Denise C Endringer; Keller G Guimarães; Tamara P Kondratyuk; John M Pezzuto; Fernão C Braga
Selective inhibition of aromatase by a dihydroisocoumarin from Xyris pterygoblephara.
Journal of natural products 2008;71(6):1082-4.
2008: Jian Guo; Dongting Liu; Dejan Nikolic; Dongwei Zhu; John M Pezzuto; Richard B Van Breemen
In vitro metabolism of isoliquiritigenin by human liver microsomes.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(2):461-8.
2007: Dongting Liu; Jian Guo; Yan Luo; David Broderick; Michael I Schimerlik; John M Pezzuto; Richard B Van Breemen
Screening for ligands of human retinoid X receptor-alpha using ultrafiltration mass spectrometry.
Analytical chemistry 2007;79(24):9398-402.
2007: Arup Maiti; Muriel Cuendet; Vicki L Croy; Denise C Endringer; John M Pezzuto; Mark Cushman
Synthesis and biological evaluation of (+/-)-abyssinone II and its analogues as aromatase inhibitors for chemoprevention of breast cancer.
Journal of medicinal chemistry 2007;50(12):2799-806.
2007: Arup Maiti; Muriel Cuendet; Tamara Kondratyuk; Vicki L Croy; John M Pezzuto; Mark Cushman
Synthesis and cancer chemopreventive activity of zapotin, a natural product from Casimiroa edulis.
Journal of medicinal chemistry 2007;50(2):350-5.
2007: Genoveva Murillo; Wendy H Hirschelman; Aiko Ito; Robert M Moriarty; A Douglas Kinghorn; John M Pezzuto; Rajendra Mehta
Zapotin, a phytochemical present in a Mexican fruit, prevents colon carcinogenesis.
Nutrition and cancer 2007;57(1):28-37.
2007: Philip G Williams; Ratnakar N Asolkar; Tamara Kondratyuk; John M Pezzuto; Paul R Jensen; William Fenical
Saliniketals A and B, bicyclic polyketides from the marine actinomycete Salinispora arenicola.
Journal of natural products 2007;70(1):83-8.
2006: Juliana K Choi; Genoveva Murillo; Bao-Ning Su; John M Pezzuto; A Douglas Kinghorn; Rajendra Mehta
Ixocarpalactone A isolated from the Mexican tomatillo shows potent antiproliferative and apoptotic activity in colon cancer cells.
The FEBS journal 2006;273(24):5714-23.
2006: Marcy J Balunas; William P Jones; Young-Won Chin; Qiuwen Mi; Norman R Farnsworth; D Doel Soejarto; Patrick Jonas; Steven M Swanson; John M Pezzuto; Hee-Byung Chai; A Douglas Kinghorn
Relationships between inhibitory activity against a cancer cell line panel, profiles of plants collected, and compound classes isolated in an anticancer drug discovery project.
Chemistry & biodiversity 2006;3(8):897-915.
2006: Anthony D Wright; Rocky de Nys; Cindy K Angerhofer; John M Pezzuto; Marion Gurrath
Biological activities and 3D QSAR studies of a series of Delisea pulchra (cf. fimbriata) derived natural products.
Journal of natural products 2006;69(8):1180-7.
2006: Dae Sik Jang; Bao-Ning Su; Alison D Pawlus; Young-Hwa Kang; Leonardus B S Kardono; Soedarsono Riswan; Johar J Afriastini; Harry H S Fong; John M Pezzuto; A Douglas Kinghorn
Beccaridiol, an unusual 28-nortriterpenoid from the leaves of Diplectria beccariana.
Phytochemistry 2006;67(16):1832-7.
2006: Zhen-Dan He; Cui-Ying Ma; Ghee Teng Tan; Kongmany Sydara; Pamela A Tamez; Bounhoong Southavong; Somsanith Bouamanivong; D Doel Soejarto; John M Pezzuto; Harry H S Fong; Hong-Jie Zhang
Rourinoside and rouremin, antimalarial constituents from Rourea minor.
Phytochemistry 2006;67(13):1378-84.
2006: Joell J Gills; Elizabeth H Jeffery; Nathan V Matusheski; Richard C Moon; Daniel D Lantvit; John M Pezzuto
Sulforaphane prevents mouse skin tumorigenesis during the stage of promotion.
Cancer letters 2006;236(1):72-9.
2006: Esperanza Carcache de Blanco; Muriel Cuendet; Eun Jung Park; Bao-Ning Su; J Fausto Rivero-Cruz; Norman R Farnsworth; John M Pezzuto; A Douglas Kinghorn
Potential cancer chemopreventive agents from Arbutus unedo.
Natural product research 2006;20(4):327-34.
2006: D Doel Soejarto; Hong-Jie Zhang; Harry H S Fong; Ghee Teng Tan; Cui-Ying Ma; Charlotte Gyllenhaal; Mary C Riley; Marian R Kadushin; Scott Franzblau; Truong Quang Bich; Nguyen Manh Cuong; Nguyen Tien Hiep; Phan Ke Loc; Le Thi Xuan; Nong Van Hai; Nguyen Van Hung; Nguyen Quyet Chien; Le Tran Binh; Bui Minh Vu; Ho Minh Ly; Bounhoong Southavong; Kongmany Sydara; Somsanith Bouamanivong; John M Pezzuto; William C Rose; Gregg R Dietzman; Byron E Miller; Tran Van Thuy
"Studies on biodiversity of Vietnam and Laos" 1998-2005: examining the impact.
Journal of natural products 2006;69(3):473-81.
2006: Muriel Cuendet; Carol P Oteham; Richard C Moon; John M Pezzuto
Quinone reductase induction as a biomarker for cancer chemoprevention.
Journal of natural products 2006;69(3):460-3.
2006: Sudarat Homhual; Nuntavan Bunyapraphatsara; Tamara Kondratyuk; Angkana Herunsalee; Wongsatit Chaukul; John M Pezzuto; Harry H S Fong; Hong-Jie Zhang
Bioactive dammarane triterpenes from the mangrove plant Bruguiera gymnorrhiza.
Journal of natural products 2006;69(3):421-4.
2006: Liqiong Fang; Aiko Ito; Hee-Byung Chai; Qiuwen Mi; William P Jones; Domingo R Madulid; Mildred B Oliveros; Qi Gao; Jimmy Orjala; Norman R Farnsworth; D Doel Soejarto; Patrick Jonas; Steven M Swanson; John M Pezzuto; A Douglas Kinghorn
Cytotoxic constituents from the stem bark of Dichapetalum gelonioides collected in the Philippines.
Journal of natural products 2006;69(3):332-7.
2006: Sudarat Homhual; Hong-Jie Zhang; Nuntavan Bunyapraphatsara; Tamara P Kondratyuk; Bernard D Santarsiero; Andrew D Mesecar; Angkana Herunsalee; Wongsatit Chaukul; John M Pezzuto; Harry H S Fong
Bruguiesulfurol, a new sulfur compound from Bruguiera gymnorrhiza.
Planta medica 2006;72(3):255-60.
2006: Hong-Jie Zhang; Cuiying Ma; Van Hung Nguyen; Manh Cuong Nguyen; Ghee Teng Tan; Bernard D Santarsiero; Andrew D Mesecar; D Doel Soejarto; John M Pezzuto; Harry H S Fong
Miliusanes, a class of cytotoxic agents from Miliusa sinensis.
Journal of medicinal chemistry 2006;49(2):693-708.
2006: Muriel Cuendet; Andrew D Mesecar; David L DeWitt; John M Pezzuto
An ELISA method to measure inhibition of the COX enzymes.
Nature protocols 2006;1(4):1915-21.
2006: Julie M Thole; Tristan F Burns Kraft; Lilly Ann Sueiro; Young-Hwa Kang; Joell J Gills; Muriel Cuendet; John M Pezzuto; David S Seigler; Mary Ann Lila
A comparative evaluation of the anticancer properties of European and American elderberry fruits.
Journal of medicinal food 2006;9(4):498-504.
2005: Ho-Young Lee; Seung-Hyun Oh; Jong K Woo; Woo-Young Kim; Carolyn S Van Pelt; Roger E Price; Dianna D Cody; Hai Tran; John M Pezzuto; Robert M Moriarty; Waun Ki Hong
Chemopreventive effects of deguelin, a novel Akt inhibitor, on tobacco-induced lung tumorigenesis.
Journal of the National Cancer Institute 2005;97(22):1695-9.
2005: A Koch; Pamela A Tamez; John M Pezzuto; D Doel Soejarto
Evaluation of plants used for antimalarial treatment by the Maasai of Kenya.
Journal of ethnopharmacology 2005;101(1-3):95-9.
2005: Zhen-Dan He; Cui-Ying Ma; Hong-Jie Zhang; Ghee Teng Tan; Pamela A Tamez; Kongmany Sydara; Somsanith Bouamanivong; Bounhoong Southavong; D Doel Soejarto; John M Pezzuto; Harry H S Fong
Antimalarial constituents from Nauclea orientalis (L.) L.
Chemistry & biodiversity 2005;2(10):1378-86.
2005: Guowen Liu; Aimee L Eggler; Birgit M Dietz; Andrew D Mesecar; Judy L Bolton; John M Pezzuto; Richard B Van Breemen
Screening method for the discovery of potential cancer chemoprevention agents based on mass spectrometric detection of alkylated Keap1.
Analytical chemistry 2005;77(19):6407-14.
2005: William P Jones; Tatiana Lobo-Echeverri; Qiuwen Mi; Heebyung Chai; Dongho Lee; D Doel Soejarto; Patrick Jonas; John M Pezzuto; Steven M Swanson; A Douglas Kinghorn
Antitumour activity of 3-chlorodeoxylapachol, a naphthoquinone from Avicennia germinans collected from an experimental plot in southern Florida.
The Journal of pharmacy and pharmacology 2005;57(9):1101-8.
2005: D Doel Soejarto; Harry H S Fong; Ghee Teng Tan; Hong-Jie Zhang; Cui-Ying Ma; Scott Franzblau; Charlotte Gyllenhaal; M C Riley; Marian R Kadushin; John M Pezzuto; L T Xuan; Nguyen Tien Hiep; Nguyen Van Hung; B M Vu; P K Loc; L X Dac; L T Binh; N Q Chien; N V Hai; Truong Quang Bich; Nguyen Manh Cuong; Bounhoong Southavong; Kongmany Sydara; Somsanith Bouamanivong; Ho Minh Ly; Tran Van Thuy; William C Rose; G R Dietzman
Ethnobotany/ethnopharmacology and mass bioprospecting: issues on intellectual property and benefit-sharing.
Journal of ethnopharmacology 2005;100(1-2):15-22.
2005: A W Chow; Genoveva Murillo; Chongwoo Yu; Richard B Van Breemen; AW Boddie; John M Pezzuto; Tapas K Das Gupta; Rajendra Mehta
Resveratrol inhibits rhabdomyosarcoma cell proliferation.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 2005;14(4):351-6.
2005: Aimee L Eggler; Guowen Liu; John M Pezzuto; Richard B Van Breemen; Andrew D Mesecar
Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(29):10070-5.
2005: Dae Sik Jang; Bao-Ning Su; Alison D Pawlus; William P Jones; Robert A Kleps; Nuntavan Bunyapraphatsara; Harry H S Fong; John M Pezzuto; A Douglas Kinghorn
Limnophilaspiroketone, a highly oxygenated phenolic derivative from Limnophila geoffrayi.
Journal of natural products 2005;68(7):1134-6.
2005: Joell J Gills; Jerome W Kosmeder; Richard C Moon; Daniel D Lantvit; John M Pezzuto
Effect of deguelin on UVB-induced skin carcinogenesis.
Journal of chemotherapy (Florence, Italy) 2005;17(3):297-301.
2005: Hong-Jie Zhang; Van Hung Nguyen; Manh Cuong Nguyen; D Doel Soejarto; John M Pezzuto; Harry H S Fong; Ghee Teng Tan
Sesquiterpenes and butenolides, natural anti-HIV constituents from Litsea verticillata.
Planta medica 2005;71(5):452-7.
2005: Pamela A Tamez; Daniel D Lantvit; Eula Lim; John M Pezzuto
Chemosensitizing action of cepharanthine against drug-resistant human malaria, Plasmodium falciparum.
Journal of ethnopharmacology 2005;98(1-2):137-42.
2005: Tatiana Lobo-Echeverri; J Fausto Rivero-Cruz; Bao-Ning Su; Hee-Byung Chai; Patrick Jonas; John M Pezzuto; Steven M Swanson; D Doel Soejarto; A Douglas Kinghorn
Constituents of the leaves and twigs of Calyptranthes pallens collected from an experimental plot in Southern Florida.
Journal of natural products 2005;68(4):577-80.
2005: Qiuwen Mi; Daniel D Lantvit; Eulenia Reyes-Lim; Heebyung Chai; Sharnelle S Phifer; Mansukh C Wani; Monroe E Wall; Ghee Teng Tan; Patrick Jonas; Norman R Farnsworth; A Douglas Kinghorn; John M Pezzuto
Apoptotic anticancer effect of alvaradoin E isolated from Alvaradoa haitiensis.
Anticancer research 2005;25(2A):779-87.
2005: J Fausto Rivero-Cruz; Raphael Lezutekong; Tatiana Lobo-Echeverri; Aiko Ito; Qiuwen Mi; Hee-Byung Chai; D Doel Soejarto; Patrick Jonas; John M Pezzuto; Steven M Swanson; Ivano Morelli; A Douglas Kinghorn
Cytotoxic constituents of the twigs of Simarouba glauca collected from a plot in Southern Florida.
Phytotherapy research : PTR 2005;19(2):136-40.
2004: Bao-Ning Su; William P Jones; Muriel Cuendet; Leonardus B S Kardono; Rachman Ismail; Soedarsono Riswan; Harry H S Fong; Norman R Farnsworth; John M Pezzuto; A Douglas Kinghorn
Constituents of the stems of Macrococculus pomiferus and their inhibitory activities against cyclooxygenases-1 and -2.
Phytochemistry 2004;65(21):2861-6.
2004: Stefan Gafner; Sang Kook Lee; Muriel Cuendet; Sophie Barthélémy; Laurent Vergnes; Serge Labidalle; Rajendra Mehta; Charles W Boone; John M Pezzuto
Biologic evaluation of curcumin and structural derivatives in cancer chemoprevention model systems.
Phytochemistry 2004;65(21):2849-59.
2004: Dae Sik Jang; Muriel Cuendet; Bao-Ning Su; Steven Totura; Soedarsono Riswan; Harry H S Fong; John M Pezzuto; A Douglas Kinghorn
Constituents of the seeds of Hernandia ovigera with inhibitory activity against cyclooxygenase-2.
Planta medica 2004;70(10):893-6.
2004: John M Pezzuto
Resveratrol: a whiff that induces a biologically specific tsunami.
Cancer biology & therapy 2004;3(9):889-90.
2004: A Douglas Kinghorn; Bao-Ning Su; Dae Sik Jang; Leng Chee Chang; Dongho Lee; Jian-Qiao Gu; Esperanza Carcache de Blanco; Alison D Pawlus; Sang Kook Lee; Eun Jung Park; Muriel Cuendet; Joell J Gills; Krishna Bhat; Hye-Sung Park; Eugenia Mata-Greenwood; Lynda L Song; Meishiang Jang; John M Pezzuto
Natural inhibitors of carcinogenesis.
Planta medica 2004;70(8):691-705.
2004: Jian-Qiao Gu; Tyler N Graf; Dongho Lee; Hee-Byung Chai; Qiuwen Mi; Leonardus B S Kardono; Fransisca M Setyowati; Rachman Ismail; Soedarsono Riswan; Norman R Farnsworth; Patrick Jonas; John M Pezzuto; Steven M Swanson; David Kroll; Joseph O Falkinham; Monroe E Wall; Mansukh C Wani; A Douglas Kinghorn; Nicholas H. Oberlies
Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.
Journal of natural products 2004;67(7):1156-61.
2004: Yongmei Li; Simonida Grubjesic; Dejan Nikolic; D Zhu; Jerome W Kosmeder; Robert M Moriarty; John M Pezzuto; Richard B Van Breemen
In vitro assessment of intestinal permeability and hepatic metabolism of 4'-bromoflavone, a promising cancer chemopreventive agent.
Xenobiotica; the fate of foreign compounds in biological systems 2004;34(6):535-47.
2004: Quyet Chien Nguyen; Van Hung Nguyen; Bernard D Santarsiero; Andrew D Mesecar; Manh Cuong Nguyen; D Doel Soejarto; John M Pezzuto; Harry H S Fong; Ghee Teng Tan
New 3-O-acyl betulinic acids from Strychnos vanprukii Craib.
Journal of natural products 2004;67(6):994-8.
2004: Konstantin Christov-Tzelkov; Richard C Moon; Daniel D Lantvit; Charles W Boone; Gary J Kelloff; Vernon E Steele; Ronald A Lubet; John M Pezzuto
Prostate intraepithelial neoplasia in Noble rats, a potential intermediate endpoint for chemoprevention studies.
European journal of cancer (Oxford, England : 1990) 2004;40(9):1404-11.
2004: Bang Yeon Hwang; Bao-Ning Su; Heebyung Chai; Qiuwen Mi; Leonardus B S Kardono; Johar J Afriastini; Soedarsono Riswan; Bernard D Santarsiero; Andrew D Mesecar; Robert Wild; Craig R Fairchild; Gregory D Vite; William C Rose; Norman R Farnsworth; Patrick Jonas; John M Pezzuto; Steven M Swanson; A Douglas Kinghorn
Silvestrol and episilvestrol, potential anticancer rocaglate derivatives from Aglaia silvestris.
The Journal of organic chemistry 2004;69(10):3350-8.
2004: Dae Sik Jang; Muriel Cuendet; Harry H S Fong; John M Pezzuto; A Douglas Kinghorn
Constituents of Asparagus officinalis evaluated for inhibitory activity against cyclooxygenase-2.
Journal of agricultural and food chemistry 2004;52(8):2218-22.
2004: Muriel Cuendet; Joell J Gills; John M Pezzuto
Brusatol-induced HL-60 cell differentiation involves NF-kappaB activation.
Cancer letters 2004;206(1):43-50.
2004: Fredyc Diaz; Hee-Byung Chai; Qiuwen Mi; Bao-Ning Su; Jose Schunke Vigo; James G Graham; Fernando Cabieses; Norman R Farnsworth; Patrick Jonas; John M Pezzuto; Steven M Swanson; A Douglas Kinghorn
Anthrone and oxanthrone C-glycosides from Picramnia latifolia collected in Peru.
Journal of natural products 2004;67(3):352-6.
2004: J Fausto Rivero-Cruz; Hee-Byung Chai; Leonardus B S Kardono; Fransisca M Setyowati; Johar J Afriatini; Soedarsono Riswan; Norman R Farnsworth; Patrick Jonas; John M Pezzuto; Steven M Swanson; A Douglas Kinghorn
Cytotoxic constituents of the twigs and leaves of Aglaia rubiginosa.
Journal of natural products 2004;67(3):343-7.
2004: Dae Sik Jang; Eun Jung Park; Young-Hwa Kang; Jose Schunke Vigo; James G Graham; Fernando Cabieses; Harry H S Fong; John M Pezzuto; A Douglas Kinghorn
Phenolic compounds obtained from stems of Couepia ulei with the potential to induce quinone reductase.
Archives of pharmacal research 2004;27(2):169-72.
2004: D Doel Soejarto; Charlotte Gyllenhaal; Harry H S Fong; L T Xuan; Nguyen Tien Hiep; Nguyen Van Hung; Truong Quang Bich; Bounhoong Southavong; Kongmany Sydara; John M Pezzuto
The UIC ICBG (University of Illinois at Chicago International Cooperative Biodiversity Group) Memorandum of Agreement: a model of benefit-sharing arrangement in natural products drug discovery and development.
Journal of natural products 2004;67(2):294-9.
2004: Muriel Cuendet; John M Pezzuto
Antitumor activity of bruceantin: an old drug with new promise.
Journal of natural products 2004;67(2):269-72.
2004: Aiko Ito; Hee-Byung Chai; Leonardus B S Kardono; Francisca M Setowati; Johar J Afriastini; Soedarsono Riswan; Norman R Farnsworth; Patrick Jonas; John M Pezzuto; Steven M Swanson; A Douglas Kinghorn
Saponins from the bark of Nephelium maingayi.
Journal of natural products 2004;67(2):201-5.
2004: Hong-Jie Zhang; Kongmany Sydara; Ghee Teng Tan; Cuiying Ma; Bounhoong Southavong; D Doel Soejarto; John M Pezzuto; Harry H S Fong
Bioactive constituents from Asparagus cochinchinensis.
Journal of natural products 2004;67(2):194-200.
2004: Muriel Cuendet; Konstantin Christov-Tzelkov; Daniel D Lantvit; Yunfan Deng; Samad Hedayat; Lawrence Helson; James D McChesney; John M Pezzuto
Multiple myeloma regression mediated by bruceantin.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(3):1170-9.
2004: Ho-Young Lee; Young-Ah Suh; Jerome W Kosmeder; John M Pezzuto; Waun Ki Hong; Jonathan M Kurie
Deguelin-induced inhibition of cyclooxygenase-2 expression in human bronchial epithelial cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(3):1074-9.
2004: Dae Sik Jang; Muriel Cuendet; Alison D Pawlus; Leonardus B S Kardono; Kazuko Kawanishi; Norman R Farnsworth; Harry H S Fong; John M Pezzuto; A Douglas Kinghorn
Potential cancer chemopreventive constituents of the leaves of Macaranga triloba.
Phytochemistry 2004;65(3):345-50.
2004: Young-Hwa Kang; John M Pezzuto
Induction of quinone reductase as a primary screen for natural product anticarcinogens.
Methods in enzymology 2004;382():380-414.
2004: Jianhua Liu; Joanna E Burdette; Yongkai Sun; S Deng; S M Schlecht; W Zheng; Dejan Nikolic; Gail B Mahady; Richard B Van Breemen; Harry H S Fong; John M Pezzuto; Judy L Bolton; Norman R Farnsworth
Isolation of linoleic acid as an estrogenic compound from the fruits of Vitex agnus-castus L. (chaste-berry).
Phytomedicine : international journal of phytotherapy and phytopharmacology 2004;11(1):18-23.
2003: Yongmei Li; Young Geun Shin; Chongwoo Yu; Jerome W Kosmeder; Wendy H Hirschelman; John M Pezzuto; Richard B Van Breemen
Increasing the throughput and productivity of Caco-2 cell permeability assays using liquid chromatography-mass spectrometry: application to resveratrol absorption and metabolism.
Combinatorial chemistry & high throughput screening 2003;6(8):757-67.
2003: Gulacti Topcu; Zeynep Aydogmus; Sedat Imre; Ahmet C Gören; John M Pezzuto; Jason A Clement; David G I Kingston
Brominated sesquiterpenes from the red alga Laurencia obtusa.
Journal of natural products 2003;66(11):1505-8.
2003: Joanna E Burdette; Jianhua Liu; Shaonong Chen; Daniel S Fabricant; Colleen E Piersen; Eric L Barker; John M Pezzuto; Andrew D Mesecar; Richard B Van Breemen; Norman R Farnsworth; Judy L Bolton
Black cohosh acts as a mixed competitive ligand and partial agonist of the serotonin receptor.
Journal of agricultural and food chemistry 2003;51(19):5661-70.
2003: Qiuwen Mi; Baoliang Cui; Daniel D Lantvit; Eulenia Reyes-Lim; Heebyung Chai; John M Pezzuto; A Douglas Kinghorn; Steven M Swanson
Pervilleine F, a new tropane alkaloid aromatic ester that reverses multidrug resistance.
Anticancer research 2003;23(5A):3607-15.
2003: Esperanza Carcache de Blanco; Young-Hwa Kang; Eun Jung Park; Bao-Ning Su; Leonardus B S Kardono; Soedarsono Riswan; Harry H S Fong; John M Pezzuto; A Douglas Kinghorn
Constituents of the stem bark of Pongamia pinnata with the potential to induce quinone reductase.
Journal of natural products 2003;66(9):1197-202.
2003: Dae Sik Jang; Eun Jung Park; Young-Hwa Kang; Michael E Hawthorne; Jose Schunke Vigo; James G Graham; Fernando Cabieses; Harry H S Fong; Rajendra Mehta; John M Pezzuto; A Douglas Kinghorn
Potential cncer chemopreventive flavonoids from the stems of Tephrosia toxicaria.
Journal of natural products 2003;66(9):1166-70.
2003: Bao-Ning Su; Young-Hwa Kang; Rosa Elena Pinos; Bernard D Santarsiero; Andrew D Mesecar; D Doel Soejarto; Harry H S Fong; John M Pezzuto; A Douglas Kinghorn
Isolation and absolute stereochemistry of coussaric acid, a new bioactive triterpenoid from the stems of Coussarea brevicaulis.
Phytochemistry 2003;64(1):293-302.
2003: Kyung-Hee Lee; Hee-Byung Chai; Pamela A Tamez; John M Pezzuto; Patrick Jonas; Khin Khin Win; Maung Tin-Wa
Biologically active alkylated coumarins from Kayea assamica.
Phytochemistry 2003;64(2):535-41.
2003: Dae Sik Jang; Eun Jung Park; Young-Hwa Kang; Bao-Ning Su; Michael E Hawthorne; Jose Schunke Vigo; James G Graham; Fernando Cabieses; Harry H S Fong; Rajendra Mehta; John M Pezzuto; A Douglas Kinghorn
Compounds obtained from sida acuta with the potential to induce quinone reductase and to inhibit 7,12-dimethylbenz[a]anthracene-induced preneoplastic lesions in a mouse mammary organ culture model.
Archives of pharmacal research 2003;26(8):585-90.
2003: Bao-Ning Su; Eun Jung Park; Dejan Nikolic; Jose Schunke Vigo; James G Graham; Fernando Cabieses; Richard B Van Breemen; Harry H S Fong; Norman R Farnsworth; John M Pezzuto; A Douglas Kinghorn
Isolation and characterization of miscellaneous secondary metabolites of Deprea subtriflora.
Journal of natural products 2003;66(8):1089-93.
2003: YingMeei Tan; Rong Yu; John M Pezzuto
Betulinic acid-induced programmed cell death in human melanoma cells involves mitogen-activated protein kinase activation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(7):2866-75.
2003: Fredyc Díaz; Daniel Chávez; Dongho Lee; Qiuwen Mi; Hee-Byung Chai; Ghee Teng Tan; Leonardus B S Kardono; Soedarsono Riswan; Craig R Fairchild; Robert Wild; Norman R Farnsworth; Patrick Jonas; John M Pezzuto; A Douglas Kinghorn
Cytotoxic flavone analogues of vitexicarpin, a constituent of the leaves of Vitex negundo.
Journal of natural products 2003;66(6):865-7.
2003: Bao-Ning Su; Eun Jung Park; Jose Schunke Vigo; James G Graham; Fernando Cabieses; Harry H S Fong; John M Pezzuto; A Douglas Kinghorn
Activity-guided isolation of the chemical constituents of Muntingia calabura using a quinone reductase induction assay.
Phytochemistry 2003;63(3):335-41.
2003: Gulacti Topcu; Esra N Altiner; Seyda Gozcu; Belkis Halfon; Zeynep Aydogmus; John M Pezzuto; Bing-Nan Zhou; David G I Kingston
Studies on di- and triterpenoids from Salvia staminea with cytotoxic activity.
Planta medica 2003;69(5):464-7.
2003: Hong-Jie Zhang; Ghee Teng Tan; Bernard D Santarsiero; Andrew D Mesecar; Nguyen Van Hung; Nguyen Manh Cuong; D Doel Soejarto; John M Pezzuto; Harry H S Fong
New Sesquiterpenes from Litsea verticillata.
Journal of natural products 2003;66(5):609-15.
2003: Dae Sik Jang; Eun Jung Park; Michael E Hawthorne; Jose Schunke Vigo; James G Graham; Fernando Cabieses; Bernard D Santarsiero; Andrew D Mesecar; Harry H S Fong; Rajendra Mehta; John M Pezzuto; A Douglas Kinghorn
Potential cancer chemopreventive constituents of the seeds of Dipteryx odorata (tonka bean).
Journal of natural products 2003;66(5):583-7.
2003: Liqiong Fang; Hee-Byung Chai; Juan J Castillo; D Doel Soejarto; Norman R Farnsworth; Patrick Jonas; John M Pezzuto; A Douglas Kinghorn
Cytotoxic constituents of Brachistus stramoniifolius.
Phytotherapy research : PTR 2003;17(5):520-3.
2003: Jian-Qiao Gu; Wenkui Li; Young-Hwa Kang; Bao-Ning Su; Harry H S Fong; Richard B Van Breemen; John M Pezzuto; A Douglas Kinghorn
Minor withanolides from Physalis philadelphica: structures, quinone reductase induction activities, and liquid chromatography (LC)-MS-MS investigation as artifacts.
Chemical & pharmaceutical bulletin 2003;51(5):530-9.
2003: Stefan Gafner; Chantal Bergeron; Laura L Batcha; Jesse Reich; John T Arnason; Joanna E Burdette; John M Pezzuto; Cindy K Angerhofer
Inhibition of [3H]-LSD binding to 5-HT7 receptors by flavonoids from Scutellaria lateriflora.
Journal of natural products 2003;66(4):535-7.
2003: Bao-Ning Su; Eun Jung Park; Dejan Nikolic; Bernard D Santarsiero; Andrew D Mesecar; Jose Schunke Vigo; James G Graham; Fernando Cabieses; Richard B Van Breemen; Harry H S Fong; Norman R Farnsworth; John M Pezzuto; A Douglas Kinghorn
Activity-guided isolation of novel norwithanolides from depreasubtriflora with potential cancer chemopreventive activity.
The Journal of organic chemistry 2003;68(6):2350-61.
2003: Genoveva Murillo; Jerome W Kosmeder; John M Pezzuto; Rajendra Mehta
Deguelin suppresses the formation of carcinogen-induced aberrant crypt foci in the colon of CF-1 mice.
International journal of cancer. Journal international du cancer 2003;104(1):7-11.
2003: Kyung-Hee Chun; Jerome W Kosmeder; Shihua Sun; John M Pezzuto; Reuben Lotan; Waun Ki Hong; Ho-Young Lee
Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells.
Journal of the National Cancer Institute 2003;95(4):291-302.
2003: Eun-Kyoung Seo; Dongho Lee; Young Geun Shin; Hee-Byung Chai; Hernán A Navarro; Leonardus B S Kardono; Ismail Rahman; Patrick Jonas; Norman R Farnsworth; John M Pezzuto; A Douglas Kinghorn; Mansukh C Wani; Monroe E Wall
Bioactive prenylated flavonoids from the stem bark of Artocarpus kemando.
Archives of pharmacal research 2003;26(2):124-7.
2003: Hong-Jie Zhang; Ghee Teng Tan; Vu Dinh Hoang; Nguyen Van Hung; Nguyen Manh Cuong; D Doel Soejarto; John M Pezzuto; Harry H S Fong
Natural anti-HIV agents. Part IV. Anti-HIV constituents from Vatica cinerea.
Journal of natural products 2003;66(2):263-8.
2003: S Omar; J Zhang; S MacKinnon; D Leaman; Tony Durst; B J R Philogene; John T Arnason; Pablo Sanchez-Vindas; Luis Poveda; P A Tamez; John M Pezzuto
Traditionally-used antimalarials from the Meliaceae.
Current topics in medicinal chemistry 2003;3(2):133-9.
2003: Chongwoo Yu; Young Geun Shin; Jerome W Kosmeder; John M Pezzuto; Richard B Van Breemen
Liquid chromatography/tandem mass spectrometric determination of inhibition of human cytochrome P450 isozymes by resveratrol and resveratrol-3-sulfate.
Rapid communications in mass spectrometry : RCM 2003;17(4):307-13.
2003: Christine J G Duncan; Muriel Cuendet; Frank R Fronczek; John M Pezzuto; Rajendra Mehta; Mark T Hamann; Samir A Ross
Chemical and biological investigation of the fungus Pulveroboletus ravenelii.
Journal of natural products 2003;66(1):103-7.
2003: Bang Yeon Hwang; Hee-Byung Chai; Leonardus B S Kardono; Soedarsono Riswan; Norman R Farnsworth; Patrick Jonas; John M Pezzuto; A Douglas Kinghorn
Cytotoxic triterpenes from the twigs of Celtis philippinensis.
Phytochemistry 2003;62(2):197-201.
2002: Haiyan Xu; Daniel S Fabricant; Colleen E Piersen; Judy L Bolton; John M Pezzuto; Harry H S Fong; Steven Totura; Norman R Farnsworth; Andreas I Constantinou
A preliminary RAPD-PCR analysis of Cimicifuga species and other botanicals used for women's health.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2002;9(8):757-62.
2002: Chongwoo Yu; Young Geun Shin; Anita Chow; Yongmei Li; Jerome W Kosmeder; Yong Sup Lee; Wendy H Hirschelman; John M Pezzuto; Rajendra Mehta; Richard B Van Breemen
Human, rat, and mouse metabolism of resveratrol.
Pharmaceutical research 2002;19(12):1907-14.
2002: Angela I Calderón; Christian Terreaux; Kurt J Schenk; Philip Pattison; Joanna E Burdette; John M Pezzuto; Mahabir P Gupta; Kurt Hostettmann
Isolation and structure elucidation of an isoflavone and a sesterterpenoic acid from Henriettella fascicularis.
Journal of natural products 2002;65(12):1749-53.
2002: Bao-Ning Su; Muriel Cuendet; Norman R Farnsworth; Harry H S Fong; John M Pezzuto; A Douglas Kinghorn
Activity-guided fractionation of the seeds of Ziziphus jujuba using a cyclooxygenase-2 inhibitory assay.
Planta medica 2002;68(12):1125-8.
2002: Hong-Jie Zhang; Pamela A Tamez; Zeynep Aydogmus; Ghee Teng Tan; Yoko Saikawa; Kimiko Hashimoto; Masaya Nakata; Nguyen Van Hung; Le Thi Xuan; Nguyen Manh Cuong; D Doel Soejarto; John M Pezzuto; Harry H S Fong
Antimalarial agents from plants. III. Trichothecenes from Ficus fistulosa and Rhaphidophora decursiva.
Planta medica 2002;68(12):1088-91.
2002: Genoveva Murillo; George I Salti; Jerome W Kosmeder; John M Pezzuto; Rajendra Mehta
Deguelin inhibits the growth of colon cancer cells through the induction of apoptosis and cell cycle arrest.
European journal of cancer (Oxford, England : 1990) 2002;38(18):2446-54.
2002: Dae Sik Jang; Muriel Cuendet; Michael E Hawthorne; Leonardus B S Kardono; Kazuko Kawanishi; Harry H S Fong; Rajendra Mehta; John M Pezzuto; A Douglas Kinghorn
Prenylated flavonoids of the leaves of Macaranga conifera with inhibitory activity against cyclooxygenase-2.
Phytochemistry 2002;61(7):867-72.
2002: Joanna E Burdette; Shaonong Chen; Zhi-Zhen Lu; Haiyan Xu; Bethany E P White; Daniel S Fabricant; Jianhua Liu; Harry H S Fong; Norman R Farnsworth; Andreas I Constantinou; Richard B Van Breemen; John M Pezzuto; Judy L Bolton
Black cohosh (Cimicifuga racemosa L.) protects against menadione-induced DNA damage through scavenging of reactive oxygen species: bioassay-directed isolation and characterization of active principles.
Journal of agricultural and food chemistry 2002;50(24):7022-8.
2002: Luisella Verotta; marco Guerrini; Nadia A El-Sebakhy; Aya M Assad; Soad M Toaima; Mohamed M Radwan; Ying-De Luo; John M Pezzuto
Cycloartane and oleanane saponins from egyptian astragalus spp. as modulators of lymphocyte proliferation.
Planta medica 2002;68(11):986-94.
2002: Jian-Qiao Gu; Eun Jung Park; Jose Schunke Vigo; James G Graham; Harry H S Fong; John M Pezzuto; A Douglas Kinghorn
Activity-guided isolation of constituents of Renealmia nicolaioides with the potential to induce the phase II enzyme quinone reductase.
Journal of natural products 2002;65(11):1616-20.
2002: Eugenia Mata-Greenwood; Muriel Cuendet; Dorie A Sher; David M Gustin; Wendy Stock; John M Pezzuto
Brusatol-mediated induction of leukemic cell differentiation and G(1) arrest is associated with down-regulation of c-myc.
Leukemia 2002;16(11):2275-84.
2002: Rajendra Mehta; John M Pezzuto
Discovery of cancer preventive agents from natural products: from plants to prevention.
Current oncology reports 2002;4(6):478-86.
2002: Dae Sik Jang; Eun Jung Park; Michael E Hawthorne; Jose Schunke Vigo; James G Graham; Fernando Cabieses; Bernard D Santarsiero; Andrew D Mesecar; Harry H S Fong; Rajendra Mehta; John M Pezzuto; A Douglas Kinghorn
Constituents of Musa x paradisiaca cultivar with the potential to induce the phase II enzyme, quinone reductase.
Journal of agricultural and food chemistry 2002;50(22):6330-4.
2002: Qiuwen Mi; Baoliang Cui; Gloria L Silva; Daniel D Lantvit; Eula Lim; Heebyung Chai; Melinda G Hollingshead; Joseph G Mayo; A Douglas Kinghorn; John M Pezzuto
Pervilleines B and C, new tropane alkaloid aromatic esters that reverse the multidrug-resistance in the hollow fiber assay.
Cancer letters 2002;184(1):13-20.
2002: Konstantin Christov-Tzelkov; Richard C Moon; Daniel D Lantvit; Charles W Boone; Vernon E Steele; Ronald A Lubet; Gary J Kelloff; John M Pezzuto
9-cis-retinoic acid but not 4-(hydroxyphenyl)retinamide inhibits prostate intraepithelial neoplasia in Noble rats.
Cancer research 2002;62(18):5178-82.
2002: Ahmet C Gören; Gülaçti Topçu; Gökhan Bilsel; Mine Bilsel; Zeynep Aydoğmuş; John M Pezzuto
The chemical constituents and biological activity of essential oil of Lavandula stoechas ssp. stoechas.
Zeitschrift für Naturforschung. C, Journal of biosciences 2002;57(9-10):797-800.
2002: Bao-Ning Su; Eun Jung Park; Zakaria H Mbwambo; Bernard D Santarsiero; Andrew D Mesecar; Harry H S Fong; John M Pezzuto; A Douglas Kinghorn
New chemical constituents of Euphorbia quinquecostata and absolute configuration assignment by a convenient Mosher ester procedure carried out in NMR tubes.
Journal of natural products 2002;65(9):1278-82.
2002: Aiko Ito; Hee-Byung Chai; Dongho Lee; Leonardus B S Kardono; Soedarsono Riswan; Norman R Farnsworth; Patrick Jonas; John M Pezzuto; A Douglas Kinghorn
Ellagic acid derivatives and cytotoxic cucurbitacins from Elaeocarpus mastersii.
Phytochemistry 2002;61(2):171-4.
2002: Bao-Ning Su; Leng Chee Chang; Eun Jung Park; Muriel Cuendet; Bernard D Santarsiero; Andrew D Mesecar; Rajendra Mehta; Harry H S Fong; John M Pezzuto; A Douglas Kinghorn
Bioactive constituents of the seeds of Brucea javanica.
Planta medica 2002;68(8):730-3.
2002: Jian-Qiao Gu; Eun Jung Park; Steven Totura; Soedarsono Riswan; Harry H S Fong; John M Pezzuto; A Douglas Kinghorn
Constituents of the twigs of Hernandia ovigera that inhibit the transformation of JB6 murine epidermal cells.
Journal of natural products 2002;65(7):1065-8.
2002: Agnes M Rimando; Muriel Cuendet; Cristian Desmarchelier; Rajendra Mehta; John M Pezzuto; Stephen O Duke
Cancer chemopreventive and antioxidant activities of pterostilbene, a naturally occurring analogue of resveratrol.
Journal of agricultural and food chemistry 2002;50(12):3453-7.
2002: Cecília T T Blatt; Daniel Chávez; Heebyung Chai; James G Graham; Fernando Cabieses; Norman R Farnsworth; Patrick Jonas; John M Pezzuto; A Douglas Kinghorn
Cytotoxic flavonoids from the stem bark of Lonchocarpus aff. fluvialis.
Phytotherapy research : PTR 2002;16(4):320-5.
2002: Qiuwen Mi; Daniel D Lantvit; Eulenia Reyes-Lim; Heebyung Chai; Weimin Zhao; Ik-Soo Lee; Sergio R Peraza-Sánchez; Olipa Ngassapa; Leonardus B S Kardono; Soedarsono Riswan; Melinda G Hollingshead; Joseph G Mayo; Norman R Farnsworth; Patrick Jonas; A Douglas Kinghorn; John M Pezzuto
Evaluation of the potential cancer chemotherapeutic efficacy of natural product isolates employing in vivo hollow fiber tests.
Journal of natural products 2002;65(6):842-50.
2002: Qiuwen Mi; Baoliang Cui; Daniel Chávez; Heebyung Chai; Haiyuan Zhu; Patrick Jonas; Samad Hedayat; A Douglas Kinghorn; John M Pezzuto
Characterization of tropane alkaloid aromatic esters that reverse the multidrug-resistance phenotype.
Anticancer research 2002;22(3):1385-97.
2002: Krishna P L Bhat; John M Pezzuto
Cancer chemopreventive activity of resveratrol.
Annals of the New York Academy of Sciences 2002;957():210-29.
2002: Rosana Misico; Lynda L Song; Adriana S Veleiro; Adriana M Cirigliano; María C Tettamanzi; Gerardo Burton; Gloria M Bonetto; Viviana E Nicotra; Gloria L Silva; Roberto R Gil; Juan C Oberti; A Douglas Kinghorn; John M Pezzuto
Induction of quinone reductase by withanolides.
Journal of natural products 2002;65(5):677-80.
2002: Daniel Chávez; Baoliang Cui; Hee-Byung Chai; Ricardo García; Miliciades Mejía; Norman R Farnsworth; Patrick Jonas; John M Pezzuto; A Douglas Kinghorn
Reversal of multidrug resistance by tropane alkaloids from the stems of Erythroxylum rotundifolium.
Journal of natural products 2002;65(4):606-10.
2002: Jian-Qiao Gu; Joell J Gills; Eun Jung Park; Eugenia Mata-Greenwood; Michael E Hawthorne; Franklin Axelrod; Pedro I Chavez; Harry H S Fong; Rajendra Mehta; John M Pezzuto; A Douglas Kinghorn
Sesquiterpenoids from Tithonia diversifolia with potential cancer chemopreventive activity.
Journal of natural products 2002;65(4):532-6.
2002: Sandro Minguzzi; Lauro E S Barata; Young Geun Shin; Patrick F Jonas; Hee-Byung Chai; Eun Jung Park; John M Pezzuto; Patrick Jonas
Cytotoxic withanolides from Acnistus arborescens.
Phytochemistry 2002;59(6):635-41.
2002: Fayez E Kandil; Mary Ann L Smith; Randy B Rogers; Marie-France Pépin; Lynda L Song; John M Pezzuto; David S Seigler
Composition of a chemopreventive proanthocyanidin-rich fraction from cranberry fruits responsible for the inhibition of 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity.
Journal of agricultural and food chemistry 2002;50(5):1063-9.
2002: Sergio R Peraza-Sánchez; Hee-Byung Chai; Young Geun Shin; Thawatchai Santisuk; Vichai Reutrakul; Norman R Farnsworth; Patrick Jonas; John M Pezzuto; A Douglas Kinghorn
Constituents of the leaves and twigs of Ficus hispida.
Planta medica 2002;68(2):186-8.
2002: Hong-Jie Zhang; Zhuting Fan; Ghee Teng Tan; Hee-Byung Chai; John M Pezzuto; Handong Sun; Harry H S Fong
Pseudoirroratin A, a new cytotoxic ent-kaurene diterpene from Isodon pseudo-irrorata.
Journal of natural products 2002;65(2):215-7.
2002: Bao-Ning Su; Muriel Cuendet; Michael E Hawthorne; Leonardus B S Kardono; Soedarsono Riswan; Harry H S Fong; Rajendra Mehta; John M Pezzuto; A Douglas Kinghorn
Constituents of the bark and twigs of Artocarpus dadah with cyclooxygenase inhibitory activity.
Journal of natural products 2002;65(2):163-9.
2002: Vu Dinh Hoang; Ghee Teng Tan; Hong-Jie Zhang; Pamela A Tamez; Nguyen Van Hung; Nguyen Manh Cuong; D Doel Soejarto; Harry H S Fong; John M Pezzuto
Natural anti-HIV agents-part I: (+)-demethoxyepiexcelsin and verticillatol from Litsea verticillata.
Phytochemistry 2002;59(3):325-9.
2002: Eun Jung Park; John M Pezzuto
Botanicals in cancer chemoprevention.
Cancer metastasis reviews 2002;21(3-4):231-55.
2002: Jerome W Kosmeder; John M Pezzuto
Novel plant-derived anticarcinogens.
IARC scientific publications 2002;156():343-7.
2002: Sang Kook Lee; Yoen-Hoi Heo; Vernon E Steele; John M Pezzuto
Induction of apoptosis by 1,4-phenylenebis(methylene)selenocyanate in cultured human colon cancer cells.
Anticancer research 2002;22(1A):97-102.
2002: Joanna E Burdette; Jianhua Liu; Daniel D Lantvit; Eula Lim; Nancy Booth; Krishna P L Bhat; Samad Hedayat; Richard B Van Breemen; Andreas I Constantinou; John M Pezzuto; Norman R Farnsworth; Judy L Bolton
Trifolium pratense (red clover) exhibits estrogenic effects in vivo in ovariectomized Sprague-Dawley rats.
The Journal of nutrition 2002;132(1):27-30.
2001: Jerome W Kosmeder; John M Pezzuto
Biological effects of resveratrol.
Antioxidants & redox signaling 2001;3(6):1041-64.
2001: Krishna P L Bhat; John M Pezzuto
Natural modulators of estrogen biosynthesis and function as chemopreventive agents.
Archives of pharmacal research 2001;24(6):473-84.
2001: Gloria L Silva; Baoliang Cui; Daniel Chávez; M You; Hee-Byung Chai; P Rasoanaivo; S M Lynn; M J O'Neill; J A Lewis; J M Besterman; A Monks; Norman R Farnsworth; Patrick Jonas; John M Pezzuto; A Douglas Kinghorn
Modulation of the multidrug-resistance phenotype by new tropane alkaloid aromatic esters from Erythroxylum pervillei.
Journal of natural products 2001;64(12):1514-20.
2001: Eugenia Mata-Greenwood; J F Daeuble; P A Grieco; J Dou; J D McChesney; Rajendra Mehta; A Douglas Kinghorn; John M Pezzuto
Novel esters of glaucarubolone as inducers of terminal differentiation of promyelocytic HL-60 cells and inhibitors of 7,12-dimethylbenz[a]anthracene-induced preneoplastic lesion formation in mouse mammary organ culture.
Journal of natural products 2001;64(12):1509-13.
2001: Luisella Verotta; marco Guerrini; Nadia A El-Sebakhy; Aya M Asaad; Soad M Toaima; M E Abou-Sheer; Y D Luo; John M Pezzuto
Cycloartane saponins from Astragalus peregrinus as modulators of lymphocyte proliferation.
Fitoterapia 2001;72(8):894-905.
2001: Gülaçti Topçu; M N Ayral; A Aydin; Ahmet C Gören; H B Chai; John M Pezzuto
Triterpenoids of the roots of Lavandula stoechas ssp. stoechas.
Die Pharmazie 2001;56(11):892-5.
2001: Eun-Kyoung Seo; Nam-Cheol Kim; Qiuwen Mi; Heebyung Chai; Monroe E Wall; Mansukh C Wani; Hernán A Navarro; Jason P Burgess; James G Graham; Fernando Cabieses; Ghee Teng Tan; Norman R Farnsworth; John M Pezzuto; A Douglas Kinghorn
Macharistol, a new cytotoxic cinnamylphenol from the stems of Machaerium aristulatum.
Journal of natural products 2001;64(11):1483-5.
2001: Krishna P L Bhat; Daniel D Lantvit; Konstantin Christov-Tzelkov; Rajendra Mehta; Richard C Moon; John M Pezzuto
Estrogenic and antiestrogenic properties of resveratrol in mammary tumor models.
Cancer research 2001;61(20):7456-63.
2001: Dongho Lee; Krishna P L Bhat; Harry H S Fong; Norman R Farnsworth; John M Pezzuto; A Douglas Kinghorn
Aromatase inhibitors from Broussonetia papyrifera.
Journal of natural products 2001;64(10):1286-93.
2001: Jian-Qiao Gu; Eun Jung Park; L Luyengi; Michael E Hawthorne; Rajendra Mehta; Norman R Farnsworth; John M Pezzuto; A Douglas Kinghorn
Constituents of Eugenia sandwicensis with potential cancer chemopreventive activity.
Phytochemistry 2001;58(1):121-7.
2001: Krishna P L Bhat; John M Pezzuto
Resveratrol exhibits cytostatic and antiestrogenic properties with human endometrial adenocarcinoma (Ishikawa) cells.
Cancer research 2001;61(16):6137-44.
2001: Patoomratana Tuchinda; Manat Pohmakotr; Vichai Reutrakul; W Thanyachareon; Samaisukh Sophasan; Chalobon Yoosook; Thawatchai Santisuk; John M Pezzuto
2-substituted furans from Polyalthia suberosa.
Planta medica 2001;67(6):572-5.
2001: Rajendra Mehta; Krishna P L Bhat; Michael E Hawthorne; L Kopelovich; Rajeshwari R Mehta; Konstantin Christov-Tzelkov; Gary J Kelloff; Vernon E Steele; John M Pezzuto
Induction of atypical ductal hyperplasia in mouse mammary gland organ culture.
Journal of the National Cancer Institute 2001;93(14):1103-6.
2001: Dongho Lee; Muriel Cuendet; Jose Schunke Vigo; James G Graham; Fernando Cabieses; Harry H S Fong; John M Pezzuto; A Douglas Kinghorn
A novel cyclooxygenase-inhibitory stilbenolignan from the seeds of Aiphanes aculeata.
Organic letters 2001;3(14):2169-71.
2001: R Yu; Vidya Hebbar; D W Kim; Sandhya Mandlekar; John M Pezzuto; Ah-Ng Tony Kong
Resveratrol inhibits phorbol ester and UV-induced activator protein 1 activation by interfering with mitogen-activated protein kinase pathways.
Molecular pharmacology 2001;60(1):217-24.
2001: Dongho Lee; E J Park; Muriel Cuendet; F Axelrod; P I Chavez; Harry H S Fong; John M Pezzuto; A Douglas Kinghorn
Cyclooxygenase-inhibitory and antioxidant constituents of the aerial parts of Antirhea acutata.
Bioorganic & medicinal chemistry letters 2001;11(12):1565-8.
2001: Hong-Jie Zhang; Pamela A Tamez; D H Vu; T T Ghee; Van Hung Nguyen; T X Le; M H Le; Manh Cuong Nguyen; T T Do; D Doel Soejarto; Harry H S Fong; John M Pezzuto
Antimalarial compounds from Rhaphidophora decursiva.
Journal of natural products 2001;64(6):772-7.
2001: Qiuwen Mi; Baoliang Cui; Gloria L Silva; Daniel D Lantvit; Eula Lim; Heebyung Chai; M You; Melinda G Hollingshead; Joseph G Mayo; A Douglas Kinghorn; John M Pezzuto
Pervilleine A, a novel tropane alkaloid that reverses the multidrug-resistance phenotype.
Cancer research 2001;61(10):4030-7.
2001: Eugenia Mata-Greenwood; A Ito; HE Westenburg; Baoliang Cui; Rajendra Mehta; A Douglas Kinghorn; John M Pezzuto
Discovery of novel inducers of cellular differentiation using HL-60 promyelocytic cells.
Anticancer research 2001;21(3B):1763-70.
2001: Jianhua Liu; Joanna E Burdette; Haiyan Xu; C Gu; Richard B Van Breemen; Krishna P L Bhat; Nancy Booth; Andreas I Constantinou; John M Pezzuto; Harry H S Fong; Norman R Farnsworth; Judy L Bolton
Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms.
Journal of agricultural and food chemistry 2001;49(5):2472-9.
2001: E J Park; D Lee; Young Geun Shin; Daniel D Lantvit; Richard B Van Breemen; A Douglas Kinghorn; John M Pezzuto
Analysis of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors using liquid chromatography-electrospray mass spectrometry.
Journal of chromatography. B, Biomedical sciences and applications 2001;754(2):327-32.
2001: George I Salti; Julia V Kichina; Tapas K Das Gupta; Shahab Uddin; Laura Bratescu; John M Pezzuto; Rajendra Mehta; Andreas I Constantinou
Betulinic acid reduces ultraviolet-C-induced DNA breakage in congenital melanocytic naeval cells: evidence for a potential role as a chemopreventive agent.
Melanoma research 2001;11(2):99-104.
2001: S D Correia; Jorge M David; Juceni P David; Hee-Byung Chai; John M Pezzuto; Patrick Jonas
Alkyl phenols and derivatives from Tapirira obtusa.
Phytochemistry 2001;56(7):781-4.
2001: Samuel X Qiu; Van Hung Nguyen; T X Le; Jian-Qiao Gu; E Lobkovsky; C K Tran; D Doel Soejarto; J Clardy; John M Pezzuto; Y Dong; V T Mai; M H Le; Harry H S Fong
A pregnane steroid from Aglaia lawii and structure confirmation of cabraleadiol monoacetate by X-ray crystallography.
Phytochemistry 2001;56(7):775-80.
2001: GO Udeani; GM Zhao; Young Geun Shin; Jerome W Kosmeder; Christopher W Beecher; A Douglas Kinghorn; Robert M Moriarty; Richard C Moon; John M Pezzuto
Pharmacokinetics of deguelin, a cancer chemopreventive agent in rats.
Cancer chemotherapy and pharmacology 2001;47(3):263-8.
2001: Aiko Ito; Baoliang Cui; Daniel Chávez; Hee-Byung Chai; Young Geun Shin; Kazuko Kawanishi; Leonardus B S Kardono; Soedarsono Riswan; Norman R Farnsworth; Patrick Jonas; John M Pezzuto; A Douglas Kinghorn
Cytotoxic polyacetylenes from the twigs of Ochanostachys amentacea.
Journal of natural products 2001;64(2):246-8.
2001: Andreas I Constantinou; Daniel D Lantvit; Michael E Hawthorne; Xiping Xu; Richard B Van Breemen; John M Pezzuto
Chemopreventive effects of soy protein and purified soy isoflavones on DMBA-induced mammary tumors in female Sprague-Dawley rats.
Nutrition and cancer 2001;41(1-2):75-81.
2001: Pierre Waffo-Téguo; Michael E Hawthorne; Muriel Cuendet; Jean-Michel Mérillon; A Douglas Kinghorn; John M Pezzuto; Rajendra Mehta
Potential cancer-chemopreventive activities of wine stilbenoids and flavans extracted from grape (Vitis vinifera) cell cultures.
Nutrition and cancer 2001;40(2):173-9.
2001: FD Horgen; RuAngelie Edrada-Ebel; G de los Reyes; F Agcaoili; D A Madulid; V Wongpanich; Cindy K Angerhofer; John M Pezzuto; D Doel Soejarto; Norman R Farnsworth
Biological screening of rain forest plot trees from Palawan Island (Philippines).
Phytomedicine : international journal of phytotherapy and phytopharmacology 2001;8(1):71-81.
2001: P Waffo-Teguo; Dongho Lee; Muriel Cuendet; Jean-Michel Mérillon; John M Pezzuto; A Douglas Kinghorn
Two new stilbene dimer glucosides from grape (Vitis vinifera) cell cultures.
Journal of natural products 2001;64(1):136-8.
2000: HE Westenburg; K J Lee; Sang Kook Lee; Harry H S Fong; Richard B Van Breemen; John M Pezzuto; A Douglas Kinghorn
Activity-guided isolation of antioxidative constituents of Cotinus coggygria.
Journal of natural products 2000;63(12):1696-8.
2000: Leng Chee Chang; Joell J Gills; Krishna P L Bhat; L Luyengi; Norman R Farnsworth; John M Pezzuto; A Douglas Kinghorn
Activity-guided isolation of constituents of Cerbera manghas with antiproliferative and antiestrogenic activities.
Bioorganic & medicinal chemistry letters 2000;10(21):2431-4.
2000: K H Cho; John M Pezzuto; Judy L Bolton; Vernon E Steele; Gary J Kelloff; Sang Kook Lee; Andreas I Constantinou
Selection of cancer chemopreventive agents based on inhibition of topoisomerase II activity.
European journal of cancer (Oxford, England : 1990) 2000;36(16):2146-56.
2000: Leng Chee Chang; Lynda L Song; Eun Jung Park; L Luyengi; K J Lee; Norman R Farnsworth; John M Pezzuto; A Douglas Kinghorn
Bioactive constituents of Thuja occidentalis.
Journal of natural products 2000;63(9):1235-8.
2000: Dejan Nikolic; S Habibi-Goudarzi; D G Corley; S Gafner; John M Pezzuto; Richard B Van Breemen
Evaluation of cyclooxygenase-2 inhibitors using pulsed ultrafiltration mass spectrometry.
Analytical chemistry 2000;72(16):3853-9.
2000: Samuel X Qiu; X C Li; Y Xiong; Y Dong; H Chai; N R Fransworth; John M Pezzuto; Harry H S Fong
Isolation and characterization of cytotoxic saponin chloromaloside A from Chlorophytum malayense.
Planta medica 2000;66(6):587-90.
2000: Hyun-Young Jeong; L C Chang; H K Kim; I H Kim; A Douglas Kinghorn; John M Pezzuto
Aromatase inhibitors from Isodon excisus var. coreanus.
Archives of pharmacal research 2000;23(3):243-5.
2000: Sergio R Peraza-Sánchez; Daniel Chávez; Hee-Byung Chai; Young Geun Shin; R García; M Mejía; Craig R Fairchild; K E Lane; Ana T Menendez; Norman R Farnsworth; Patrick Jonas; John M Pezzuto; A Douglas Kinghorn
Cytotoxic constituents of the roots of Ekmanianthe longiflora.
Journal of natural products 2000;63(4):492-5.
2000: Eun-Kyoung Seo; Hee-Byung Chai; T E Chagwedera; Norman R Farnsworth; Patrick Jonas; John M Pezzuto; A Douglas Kinghorn
5-(4-Hydroxyphenethenyl)-4,7-dimethoxycoumarin, a new constituent of Monotes engleri.
Planta medica 2000;66(2):182-4.
2000: Bolanle A Adeniyi; Harry H S Fong; John M Pezzuto; L Luyengi; HA Odelola
Antibacterial activity of diospyrin, isodiospyrin and bisisodiospyrin from the root of Diospyros piscatoria (Gurke) (Ebenaceae).
Phytotherapy research : PTR 2000;14(2):112-7.
2000: Leng Chee Chang; Daniel Chávez; Lynda L Song; Norman R Farnsworth; John M Pezzuto; A Douglas Kinghorn
Absolute configuration of novel bioactive flavonoids from Tephrosia purpurea.
Organic letters 2000;2(4):515-8.
2000: Muriel Cuendet; John M Pezzuto
The role of cyclooxygenase and lipoxygenase in cancer chemoprevention.
Drug metabolism and drug interactions 2000;17(1-4):109-57.
1999: Sang Kook Lee; John M Pezzuto
Evaluation of the potential of cancer chemopreventive activity mediated by inhibition of 12-O-tetradecanoyl phorbol 13-acetate-induced ornithine decarboxylase activity.
Archives of pharmacal research 1999;22(6):559-64.
1999: GO Udeani; GM Zhao; Y Geun Shin; B P Cooke; James G Graham; Christopher W Beecher; A Douglas Kinghorn; John M Pezzuto
Pharmacokinetics and tissue distribution of betulinic acid in CD-1 mice.
Biopharmaceutics & drug disposition 1999;20(8):379-83.
1999: Baoliang Cui; Y H Lee; Heebyung Chai; J C Tucker; Craig R Fairchild; Carmen Raventos-Suarez; B Long; K E Lane; Ana T Menendez; Christopher W Beecher; Patrick Jonas; John M Pezzuto; A Douglas Kinghorn
Cytotoxic sesquiterpenoids from Ratibida columnifera.
Journal of natural products 1999;62(11):1545-50.
1999: Young Geun Shin; K H Cho; S M Chung; James G Graham; Tapas K Das Gupta; John M Pezzuto
Determination of betulinic acid in mouse blood, tumor and tissue homogenates by liquid chromatography-electrospray mass spectrometry.
Journal of chromatography. B, Biomedical sciences and applications 1999;732(2):331-6.
1999: Aiko Ito; Y H Lee; Hee-Byung Chai; M P Gupta; Norman R Farnsworth; Patrick Jonas; John M Pezzuto; A Douglas Kinghorn
1',2',3',4'-tetradehydrotubulosine, a cytotoxic alkaloid from Pogonopus speciosus.
Journal of natural products 1999;62(9):1346-8.
1999: Baoliang Cui; Heebyung Chai; Y Dong; FD Horgen; B Hansen; D A Madulid; D Doel Soejarto; Norman R Farnsworth; Patrick Jonas; John M Pezzuto; A Douglas Kinghorn
Quinoline alkaloids from Acronychia laurifolia.
Phytochemistry 1999;52(1):95-8.
1999: Hyun-Young Jeong; Young Geun Shin; I H Kim; John M Pezzuto
Inhibition of aromatase activity by flavonoids.
Archives of pharmacal research 1999;22(3):309-12.
1999: Gülaçti Topçu; R Erenler; O Cakmak; C B Johansson; C Celik; H B Chai; John M Pezzuto
Diterpenes from the berries of Juniperus excelsa.
Phytochemistry 1999;50(7):1195-9.
1999: LZ Lin; S F Hu; M Chu; T M Chan; Heebyung Chai; Cindy K Angerhofer; John M Pezzuto; Patrick Jonas
Phenolic aporphine-benzylisoquinoline alkaloids from Thalictrum faberi.
Phytochemistry 1999;50(5):829-34.
1999: Sang Kook Lee; L Luyengi; C Gerhäuser; W Mar; K Lee; Rajendra Mehta; A Douglas Kinghorn; John M Pezzuto
Inhibitory effect of munetone, an isoflavonoid, on 12-O-tetradecanoylphorbol 13-acetate-induced ornithine decarboxylase activity.
Cancer letters 1999;136(1):59-65.
1999: Lynda L Song; Jerome W Kosmeder; Sang Kook Lee; C Gerhäuser; Daniel D Lantvit; Richard C Moon; Robert M Moriarty; John M Pezzuto
Cancer chemopreventive activity mediated by 4'-bromoflavone, a potent inducer of phase II detoxification enzymes.
Cancer research 1999;59(3):578-85.
1999: H S Chung; L C Chang; S K Lee; L A Shamon; Richard B Van Breemen; Rajendra Mehta; Norman R Farnsworth; John M Pezzuto; A Douglas Kinghorn
Flavonoid constituents of Chorizanthe diffusa with potential cancer chemopreventive activity.
Journal of agricultural and food chemistry 1999;47(1):36-41.
1999: M Jang; John M Pezzuto
Cancer chemopreventive activity of resveratrol.
Drugs under experimental and clinical research 1999;25(2-3):65-77.
1999: Sang Kook Lee; L Song; Eugenia Mata-Greenwood; Gary J Kelloff; Vernon E Steele; John M Pezzuto
Modulation of in vitro biomarkers of the carcinogenic process by chemopreventive agents.
Anticancer research 1999;19(1A):35-44.
1999: Cindy K Angerhofer; Hélène Guinaudeau; V Wongpanich; John M Pezzuto; Patrick Jonas
Antiplasmodial and cytotoxic activity of natural bisbenzylisoquinoline alkaloids.
Journal of natural products 1999;62(1):59-66.
1998: M Jang; John M Pezzuto
Effects of resveratrol on 12-O-tetradecanoylphorbol-13-acetate-induced oxidative events and gene expression in mouse skin.
Cancer letters 1998;134(1):81-9.
1998: Chalobon Yoosook; Vichai Reutrakul; Thawatchai Santisuk; S Chaichana; John M Pezzuto; Y Dong; D J Clanton; R Kiser; P Staley
A sensitive assay for anti-HIV-1 drug discovery in a biological safety level-2 laboratory.
The Southeast Asian journal of tropical medicine and public health 1998;29(4):758-62.
1998: Samuel X Qiu; H D Sun; E Lobkovsky; H Chai; J Clardy; Norman R Farnsworth; John M Pezzuto; Harry H S Fong
Megathyrin B: a cytotoxic diterpene from Isodon megathyrsus.
Planta medica 1998;64(8):728-31.
1998: Baoliang Cui; Heebyung Chai; Thawatchai Santisuk; Vichai Reutrakul; Norman R Farnsworth; Patrick Jonas; John M Pezzuto; A Douglas Kinghorn
Novel cytotoxic acylated oligorhamnosides from Mezzettia leptopoda.
Journal of natural products 1998;61(12):1535-8.
1998: S K Lee; B Cui; Rajeshwari R Mehta; A Douglas Kinghorn; John M Pezzuto
Cytostatic mechanism and antitumor potential of novel 1H-cyclopenta[b]benzofuran lignans isolated from Aglaia elliptica.
Chemico-biological interactions 1998;115(3):215-28.
1998: Leng Chee Chang; Krishna P L Bhat; Emily Pisha; Edward J Kennelly; Harry H S Fong; John M Pezzuto; A Douglas Kinghorn
Activity-guided isolation of steroidal alkaloid antiestrogen-binding site inhibitors from Pachysandra procumbens.
Journal of natural products 1998;61(10):1257-62.
1998: Sang Kook Lee; W G Qing; W Mar; L Luyengi; Rajendra Mehta; K Kawanishi; Harry H S Fong; Christopher W Beecher; A Douglas Kinghorn; John M Pezzuto
Angoline and chelerythrine, benzophenanthridine alkaloids that do not inhibit protein kinase C.
The Journal of biological chemistry 1998;273(31):19829-33.
1998: Darrick S H L Kim; John M Pezzuto; Emily Pisha
Synthesis of betulinic acid derivatives with activity against human melanoma.
Bioorganic & medicinal chemistry letters 1998;8(13):1707-12.
1998: Esperanza Carcache de Blanco; L Luyengi; Sang Kook Lee; L F Zhu; B N Zhou; Harry H S Fong; John M Pezzuto; A Douglas Kinghorn
Antioxidant flavonoid glycosides from Daphniphyllum calycinum.
Journal of natural products 1998;61(5):706-8.
1998: Sang Kook Lee; Zakaria H Mbwambo; H Chung; L Luyengi; Esperanza Carcache de Blanco; Rajendra Mehta; A Douglas Kinghorn; John M Pezzuto
Evaluation of the antioxidant potential of natural products.
Combinatorial chemistry & high throughput screening 1998;1(1):35-46.
1998: O Poobrasert; H L Constant; Christopher W Beecher; Norman R Farnsworth; A Douglas Kinghorn; John M Pezzuto; Patrick Jonas; Thawatchai Santisuk; Vichai Reutrakul
Xanthones from the twigs of Mammea siamensis.
Phytochemistry 1998;47(8):1661-3.
1998: Baoliang Cui; Heebyung Chai; H L Constant; Thawatchai Santisuk; Vichai Reutrakul; Christopher W Beecher; Norman R Farnsworth; Patrick Jonas; John M Pezzuto; A Douglas Kinghorn
Limonoids from Azadirachta excelsa.
Phytochemistry 1998;47(7):1283-7.
1998: Jorge M David; J P Chávez; Hee-Byung Chai; John M Pezzuto; Patrick Jonas
Two new cytotoxic compounds from Tapirira guianensis.
Journal of natural products 1998;61(2):287-9.
1997: FD Horgen; D A Madulid; John M Pezzuto; D Doel Soejarto; Cindy K Angerhofer; Norman R Farnsworth
Isolation of gallic acid esters as antiplasmodial constituents of Swintonia foxworthyi (Anacardiaceae).
Phytomedicine : international journal of phytotherapy and phytopharmacology 1997;4(4):353-6.
1997: Nazli Arda; N Gören; Alev Kuru; T Pengsuparp; John M Pezzuto; Samuel X Qiu; Patrick Jonas
Saniculoside N from Sanicula europaea L.
Journal of natural products 1997;60(11):1170-3.
1997: Mary Lou Schmidt; K L Kuzmanoff; L Ling-Indeck; John M Pezzuto
Betulinic acid induces apoptosis in human neuroblastoma cell lines.
European journal of cancer (Oxford, England : 1990) 1997;33(12):2007-10.
1997: Judy L Bolton; Emily Pisha; L Shen; ES Krol; S L Iverson; Z Huang; Richard B Van Breemen; John M Pezzuto
The reactivity of o-quinones which do not isomerize to quinone methides correlates with alkylcatechol-induced toxicity in human melanoma cells.
Chemico-biological interactions 1997;106(2):133-48.
1997: Leng Chee Chang; C Gerhäuser; L Song; Norman R Farnsworth; John M Pezzuto; A Douglas Kinghorn
Activity-guided isolation of constituents of Tephrosia purpurea with the potential to induce the phase II enzyme, quinone reductase.
Journal of natural products 1997;60(9):869-73.
1997: C Gerhauser; Sang Kook Lee; Jerome W Kosmeder; Robert M Moriarty; E Hamel; Rajendra Mehta; Richard C Moon; John M Pezzuto
Regulation of ornithine decarboxylase induction by deguelin, a natural product cancer chemopreventive agent.
Cancer research 1997;57(16):3429-35.
1997: GO Udeani; C Gerhauser; C F Thomas; Richard C Moon; Jerome W Kosmeder; A Douglas Kinghorn; Robert M Moriarty; John M Pezzuto
Cancer chemopreventive activity mediated by deguelin, a naturally occurring rotenoid.
Cancer research 1997;57(16):3424-8.
1997: Eun-Kyoung Seo; Gloria L Silva; Hee-Byung Chai; T E Chagwedera; Norman R Farnsworth; Patrick Jonas; John M Pezzuto; A Douglas Kinghorn
Cytotoxic prenylated flavanones from Monotes engleri.
Phytochemistry 1997;45(3):509-15.
1997: FD Horgen; Hélène Guinaudeau; John M Pezzuto; D Doel Soejarto; Norman R Farnsworth; F Agcaoili; G de los Reyes; RuAngelie Edrada-Ebel
Isolation and structure elucidation of ardisenone: a new, cytotoxic alkenylphenol from Ardisia iwahigensis.
Journal of natural products 1997;60(5):533-5.
1997: L Shen; Emily Pisha; Z Huang; John M Pezzuto; ES Krol; Z Alam; Richard B Van Breemen; Judy L Bolton
Bioreductive activation of catechol estrogen-ortho-quinones: aromatization of the B ring in 4-hydroxyequilenin markedly alters quinoid formation and reactivity.
Carcinogenesis 1997;18(5):1093-101.
1997: S MacKinnon; Tony Durst; John T Arnason; Cindy K Angerhofer; John M Pezzuto; Pablo Sanchez-Vindas; Luis Poveda; Messanvi Gbeassor
Antimalarial activity of tropical Meliaceae extracts and gedunin derivatives.
Journal of natural products 1997;60(4):336-41.
1997: H Mehdi; Jaber S Mossa; M E Peeples; John M Pezzuto; Mohammed A Al-Yahya; Farouk S El-Feraly; Norman R Farnsworth; Harry H S Fong; Michael R Kernan; Ghee Teng Tan; EJ Rozhon
Cell culture assay system for the evaluation of natural product-mediated anti-Hepatitis B virus activity.
Phytomedicine : international journal of phytotherapy and phytopharmacology 1997;3(4):369-77.
1997: L A Shamon; John M Pezzuto; Jewell M Graves; Rajeshwari R Mehta; S Wangcharoentrakul; R Sangsuwan; S Chaichana; Patoomratana Tuchinda; P Cleason; Vichai Reutrakul
Evaluation of the mutagenic, cytotoxic, and antitumor potential of triptolide, a highly oxygenated diterpene isolated from Tripterygium wilfordii.
Cancer letters 1997;112(1):113-7.
1997: C Gerhäuser; M You; Jianhua Liu; Robert M Moriarty; Michael E Hawthorne; Rajendra Mehta; Richard C Moon; John M Pezzuto
Cancer chemopreventive potential of sulforamate, a novel analogue of sulforaphane that induces phase 2 drug-metabolizing enzymes.
Cancer research 1997;57(2):272-8.
1997: M Jang; L Cai; GO Udeani; K V Slowing; C F Thomas; Christopher W Beecher; Harry H S Fong; Norman R Farnsworth; A Douglas Kinghorn; Rajendra Mehta; Richard C Moon; John M Pezzuto
Cancer chemopreventive activity of resveratrol, a natural product derived from grapes.
Science (New York, N.Y.) 1997;275(5297):218-20.
1996: M E Wall; M C Wani; J B Olwald; John M Pezzuto; N M Thornton; Christopher W Beecher; D M Brown; G A Cordell; Norman R Farnsworth; F Fullas; F F Josephson; A D Kinghorn
Effect of tannins on screening of plant extracts for enzyme inhibitory activity and techniques for their removal.
Phytomedicine : international journal of phytotherapy and phytopharmacology 1996;3(3):281-5.
1996: Z H Mbwambo; Sang Kook Lee; E N Mshiu; John M Pezzuto; A Douglas Kinghorn
Constituents from the stem wood of Euphorbia quinquecostata with phorbol dibutyrate receptor-binding inhibitory activity.
Journal of natural products 1996;59(11):1051-5.
1996: T Pengsuparp; M Serit; S H Hughes; D Doel Soejarto; John M Pezzuto
Specific inhibition of human immunodeficiency virus type 1 reverse transcriptase mediated by soulattrolide, a coumarin isolated from the latex of calophyllum teysmannii.
Journal of natural products 1996;59(9):839-42.
1996: L Luyengi; N Suh; Harry H S Fong; John M Pezzuto; A Douglas Kinghorn
A lignan and four terpenoids from Brucea javanica that induce differentiation with cultured HL-60 promyelocytic leukemia cells.
Phytochemistry 1996;43(2):409-12.
1996: T Pengsuparp; D G Kingston; K A Neidigh; Patrick Jonas; John M Pezzuto
Evaluation of the cytotoxic mechanism mediated by baccatin III, the synthetic precursor of taxol.
Chemico-biological interactions 1996;101(2):103-14.
1996: S Sturm; R R Gil; H B Chai; O D Ngassapa; Thawatchai Santisuk; Vichai Reutrakul; A Howe; M Moss; J M Besterman; S L Yang; J E Farthing; R M Tait; J A Lewis; M J O'Neill; Norman R Farnsworth; Patrick Jonas; John M Pezzuto; A Douglas Kinghorn
Lupane derivatives from Lophopetalum wallichii with farnesyl protein transferase inhibitory activity.
Journal of natural products 1996;59(7):658-63.
1996: Han-Dong Sun; S X Qiu; LZ Lin; Z Y Wang; Zhong-Wen Lin; T Pengsuparp; John M Pezzuto; Harry H S Fong; Patrick Jonas; Norman R Farnsworth
Nigranoic acid, a triterpenoid from Schisandra sphaerandra that inhibits HIV-1 reverse transcriptase.
Journal of natural products 1996;59(5):525-7.
1996: S Oksüz; F Gürek; LZ Lin; R R Gil; John M Pezzuto; Patrick Jonas
Aleppicatines A and B from Euphorbia aleppica.
Phytochemistry 1996;42(2):473-8.
1996: G T Tan; S Lee; I S Lee; J Chen; P Leitner; J M Besterman; A Douglas Kinghorn; John M Pezzuto
Natural-product inhibitors of human DNA ligase I.
The Biochemical journal 1996;314 ( Pt 3)():993-1000.
1996: L Huang; F Fullas; R J McGivney; D M Brown; Mansukh C Wani; Monroe E Wall; J C Tucker; Christopher W Beecher; John M Pezzuto; A Douglas Kinghorn
A new prenylated flavonol from the root of Petalostemon purpureus.
Journal of natural products 1996;59(3):290-2.
1996: I S Lee; L A Shamon; H B Chai; T E Chagwedera; J M Besterman; Norman R Farnsworth; Patrick Jonas; John M Pezzuto; A Douglas Kinghorn
Cell-cycle specific cytotoxicity mediated by rearranged ent-kaurene diterpenoids isolated from Parinari curatellifolia.
Chemico-biological interactions 1996;99(1-3):193-204.
1995: D J Leaman; John T Arnason; R Yusuf; H Sangat-Roemantyo; H Soedjito; Cindy K Angerhofer; John M Pezzuto
Malaria remedies of the Kenyah of the Apo Kayan, East Kalimantan, Indonesian Borneo: a quantitative assessment of local consensus as an indicator of biological efficacy.
Journal of ethnopharmacology 1995;49(1):1-16.
1995: LZ Lin; S F Hu; H B Chai; T Pengsuparp; John M Pezzuto; Patrick Jonas; Nijsiri Ruangrungsi
Lycorine alkaloids from Hymenocallis littoralis.
Phytochemistry 1995;40(4):1295-8.
1995: F Fullas; D M Brown; Mansukh C Wani; Monroe E Wall; T E Chagwedera; Norman R Farnsworth; John M Pezzuto; A Douglas Kinghorn
Gummiferol, a cytotoxic polyacetylene from the leaves of Adenia gummifera.
Journal of natural products 1995;58(10):1625-8.
1995: G L Silva; H Chai; M P Gupta; Norman R Farnsworth; Patrick Jonas; John M Pezzuto; Christopher W Beecher; A Douglas Kinghorn
Cytotoxic biflavonoids from Selaginella willdenowii.
Phytochemistry 1995;40(1):129-34.
1995: B S Falch; Gabriele M König; Anthony D Wright; Otto Sticher; Cindy K Angerhofer; John M Pezzuto; H Bachmann
Biological activities of cyanobacteria: evaluation of extracts and pure compounds.
Planta medica 1995;61(4):321-8.
1995: T Pengsuparp; L Cai; H Constant; Harry H S Fong; LZ Lin; A Douglas Kinghorn; John M Pezzuto; Patrick Jonas; K Ingolfsdóttir; H Wagner
Mechanistic evaluation of new plant-derived compounds that inhibit HIV-1 reverse transcriptase.
Journal of natural products 1995;58(7):1024-31.
1995: R R Gil; LZ Lin; H B Chai; John M Pezzuto; Patrick Jonas
Cardenolides from Nierembergia aristata.
Journal of natural products 1995;58(6):848-56.
1995: M You; D B Wickramaratne; G L Silva; H Chai; T E Chagwedera; Norman R Farnsworth; Patrick Jonas; A Douglas Kinghorn; John M Pezzuto
(-)-Roemerine, an aporphine alkaloid from Annona senegalensis that reverses the multidrug-resistance phenotype with cultured cells.
Journal of natural products 1995;58(4):598-604.
1995: S Oksüz; F Gürek; R R Gil; T Pengsuparp; John M Pezzuto; Patrick Jonas
Four diterpene esters from Euphorbia myrsinites.
Phytochemistry 1995;38(6):1457-62.
1995: N Suh; L Luyengi; Harry H S Fong; A Douglas Kinghorn; John M Pezzuto
Discovery of natural product chemopreventive agents utilizing HL-60 cell differentiation as a model.
Anticancer research 1995;15(2):233-9.
1995: Rajendra Mehta; Jianhua Liu; Andreas I Constantinou; C F Thomas; M Hawthorne; Ming You; C Gerhüser; John M Pezzuto; Richard C Moon; Robert M Moriarty
Cancer chemopreventive activity of brassinin, a phytoalexin from cabbage.
Carcinogenesis 1995;16(2):399-404.
1995: D B Wickramaratne; W Mar; H Chai; J J Castillo; Norman R Farnsworth; D Doel Soejarto; Patrick Jonas; John M Pezzuto; A Douglas Kinghorn
Cytotoxic constituents of Bursera permollis.
Planta medica 1995;61(1):80-1.
1995: Han-Dong Sun; Zhong-Wen Lin; F D Niu; LZ Lin; H B Chai; John M Pezzuto; Patrick Jonas
Cytotoxic ent-kaurene diterpenoids from three Isodon species.
Phytochemistry 1995;38(2):437-42.
1994: S Oksüz; R R Gil; H Chai; John M Pezzuto; Patrick Jonas; Ayhan Ulubelen
Biologically active compounds from the Euphorbiaceae; 2. Two triterpenoids of Euphorbia cyparissias.
Planta medica 1994;60(6):594-6.
1994: Gabriele M König; Anthony D Wright; Otto Sticher; Cindy K Angerhofer; John M Pezzuto
Biological activities of selected marine natural products.
Planta medica 1994;60(6):532-7.
1994: X Ma; I S Lee; H B Chai; K Zaw; Norman R Farnsworth; D Doel Soejarto; Patrick Jonas; John M Pezzuto; A Douglas Kinghorn
Cytotoxic clerodane diterpenes from Polyalthia barnesii.
Phytochemistry 1994;37(6):1659-62.
1994: M You; X Ma; R Mukherjee; Norman R Farnsworth; Patrick Jonas; A Douglas Kinghorn; John M Pezzuto
Indole alkaloids from Peschiera laeta that enhance vinblastine-mediated cytotoxicity with multidrug-resistant cells.
Journal of natural products 1994;57(11):1517-22.
1994: LZ Lin; S F Hu; K Zaw; Cindy K Angerhofer; H Chai; John M Pezzuto; Patrick Jonas; J Lin; D M Zheng
Thalifaberidine, a cytotoxic aporphine-benzylisoquinoline alkaloid from Thalictrum faberi.
Journal of natural products 1994;57(10):1430-6.
1994: Han-Dong Sun; Zhong-Wen Lin; F D Niu; LZ Lin; H Chai; John M Pezzuto; Patrick Jonas
Cytotoxic diterpenoids from Isodon megathyrsus.
Journal of natural products 1994;57(10):1424-9.
1994: L A Shamon; C Chen; Rajendra Mehta; V Steele; Richard C Moon; John M Pezzuto
A correlative approach for the identification of antimutagens that demonstrate chemopreventive activity.
Anticancer research 1994;14(5A):1775-8.
1994: A M Rimando; John M Pezzuto; Norman R Farnsworth; Thawatchai Santisuk; Vichai Reutrakul; K Kawanishi
New lignans from Anogeissus acuminata with HIV-1 reverse transcriptase inhibitory activity.
Journal of natural products 1994;57(7):896-904.
1994: F Fullas; R A Hussain; H B Chai; John M Pezzuto; D Doel Soejarto; A Douglas Kinghorn
Cytotoxic constituents of Baccharis gaudichaudiana.
Journal of natural products 1994;57(6):801-7.
1994: Monroe E Wall; Mansukh C Wani; F Fullas; J B Oswald; D M Brown; Thawatchai Santisuk; Vichai Reutrakul; Andrew T McPhail; Norman R Farnsworth; John M Pezzuto
Plant antitumor agents. 31. The calycopterones, a new class of biflavonoids with novel cytotoxicity in a diverse panel of human tumor cell lines.
Journal of medicinal chemistry 1994;37(10):1465-70.
1994: Rajendra Mehta; Jianhua Liu; Andreas I Constantinou; M Hawthorne; John M Pezzuto; Richard C Moon; Robert M Moriarty
Structure-activity relationships of brassinin in preventing the development of carcinogen-induced mammary lesions in organ culture.
Anticancer research 1994;14(3A):1209-13.
1994: T Pengsuparp; L Cai; Harry H S Fong; A Douglas Kinghorn; John M Pezzuto; M C Wani; M E Wall
Pentacyclic triterpenes derived from Maprounea africana are potent inhibitors of HIV-1 reverse transcriptase.
Journal of natural products 1994;57(3):415-8.
1994: O Ngassapa; D Doel Soejarto; John M Pezzuto; Norman R Farnsworth
Quinone-methide triterpenes and salaspermic acid from Kokoona ochracea.
Journal of natural products 1994;57(1):1-8.
1993: D B Wickramaratne; T Pengsuparp; W Mar; H B Chai; T E Chagwedera; Christopher W Beecher; Norman R Farnsworth; A Douglas Kinghorn; John M Pezzuto; Patrick Jonas
Novel antimitotic dibenzocyclo-octadiene lignan constituents of the stem bark of Steganotaenia araliacea.
Journal of natural products 1993;56(12):2083-90.
1993: L Luyengi; John M Pezzuto; Donald Paul Waller; Christopher W Beecher; Harry H S Fong; Chun-Tao Che; P E Bowen
Linusitamarin, a new phenylpropanoid glucoside from Linum usitatissimum.
Journal of natural products 1993;56(11):2012-5.
1993: O Ngassapa; Christopher W Beecher; John M Pezzuto; Norman R Farnsworth; Thomas O Henderson; G L Boye
Isolation of echinocystic acid-3-O-sulfate, a new triterpene, from Tetrapleura tetraptera, and evaluation of the mutagenic potential of molluscicidal extracts and isolates.
Journal of natural products 1993;56(11):1872-7.
1993: M Novelo; J G Cruz; L Hernández; Rogelio Pereda-Miranda; H Chai; W Mar; John M Pezzuto
Cytotoxic constituents from Hyptis verticillata.
Journal of natural products 1993;56(10):1728-36.
1993: O Ngassapa; D Doel Soejarto; John M Pezzuto; Norman R Farnsworth; Chun-Tao Che
Further lupane lactones from Kokoona ochracea.
Journal of natural products 1993;56(10):1676-81.
1993: N I Baek; M S Chung; L Shamon; L B Kardono; S Tsauri; K Padmawinata; John M Pezzuto; D Doel Soejarto; A Douglas Kinghorn
Selligueain A, a novel highly sweet proanthocyanidin from the rhizomes of Selliguea feei.
Journal of natural products 1993;56(9):1532-8.
1993: Kittisak Likhitwitayawuid; Cindy K Angerhofer; H Chai; John M Pezzuto; Patrick Jonas; Nijsiri Ruangrungsi
Cytotoxic and antimalarial alkaloids from the tubers of Stephania pierrei.
Journal of natural products 1993;56(9):1468-78.
1993: Kittisak Likhitwitayawuid; Cindy K Angerhofer; H Chai; John M Pezzuto; Patrick Jonas; Nijsiri Ruangrungsi
Cytotoxic and antimalarial alkaloids from the bulbs of Crinum amabile.
Journal of natural products 1993;56(8):1331-8.
1993: G T Tan; A Wickramasinghe; S Verma; S H Hughes; John M Pezzuto; M Baba; P Mohan
Sulfonic acid polymers are potent inhibitors of HIV-1 induced cytopathogenicity and the reverse transcriptases of both HIV-1 and HIV-2.
Biochimica et biophysica acta 1993;1181(2):183-8.
1993: Rogelio Pereda-Miranda; L Hernández; M J Villavicencio; M Novelo; P Ibarra; H Chai; John M Pezzuto
Structure and stereochemistry of pectinolides A-C, novel antimicrobial and cytotoxic 5,6-dihydro-alpha-pyrones from Hyptis pectinata.
Journal of natural products 1993;56(4):583-93.
1993: Rogelio Pereda-Miranda; Rachel Mata; A L Anaya; D B Wickramaratne; John M Pezzuto; A D Kinghorn
Tricolorin A, major phytogrowth inhibitor from Ipomoea tricolor.
Journal of natural products 1993;56(4):571-82.
1993: Ekarin Saifah; J Puripattanavong; Kittisak Likhitwitayawuid; Patrick Jonas; H Chai; John M Pezzuto
Bisamides from Aglaia species: structure analysis and potential to reverse drug resistance with cultured cells.
Journal of natural products 1993;56(4):473-7.
1993: A Somanabandhu; S Nitayangkura; C Mahidol; S Ruchirawat; Kittisak Likhitwitayawuid; H L Shieh; H Chai; John M Pezzuto; Patrick Jonas
1H- and 13C-nmr assignments of phyllanthin and hypophyllanthin: lignans that enhance cytotoxic responses with cultured multidrug-resistant cells.
Journal of natural products 1993;56(2):233-9.
1993: Kittisak Likhitwitayawuid; Cindy K Angerhofer; Patrick Jonas; John M Pezzuto; Nijsiri Ruangrungsi
Cytotoxic and antimalarial bisbenzylisoquinoline alkaloids from Stephania erecta.
Journal of natural products 1993;56(1):30-8.
1993: LZ Lin; H L Shieh; Cindy K Angerhofer; John M Pezzuto; Patrick Jonas; L Xue; Michael E Johnson; Nijsiri Ruangrungsi
Cytotoxic and antimalarial bisbenzylisoquinoline alkaloids from Cyclea barbata.
Journal of natural products 1993;56(1):22-9.
1992: G T Tan; A Wickramasinghe; S Verma; R Singh; S H Hughes; John M Pezzuto; M Baba; P Mohan
Potential anti-AIDS naphthalenesulfonic acid derivatives. Synthesis and inhibition of HIV-1 induced cytopathogenesis and HIV-1 and HIV-2 reverse transcriptase activities.
Journal of medicinal chemistry 1992;35(26):4846-53.
1992: Cindy K Angerhofer; John M Pezzuto; Gabriele M König; Anthony D Wright; Otto Sticher
Antimalarial activity of sesquiterpenes from the marine sponge Acanthella klethra.
Journal of natural products 1992;55(12):1787-9.
1992: N Kaneda; H Chai; John M Pezzuto; A Douglas Kinghorn; Norman R Farnsworth; P Tuchinda; J Udchachon; Thawatchai Santisuk; Vichai Reutrakul
Cytotoxic activity of cardenolides from Beaumontia brevituba stems.
Planta medica 1992;58(5):429-31.
1992: G T Tan; J F Miller; A Douglas Kinghorn; S H Hughes; John M Pezzuto
HIV-1 and HIV-2 reverse transcriptases: a comparative study of sensitivity to inhibition by selected natural products.
Biochemical and biophysical research communications 1992;185(1):370-8.
1992: N Kaneda; John M Pezzuto; A Douglas Kinghorn; Norman R Farnsworth; Thawatchai Santisuk; P Tuchinda; J Udchachon; Vichai Reutrakul
Plant anticancer agents, L. cytotoxic triterpenes from Sandoricum koetjape stems.
Journal of natural products 1992;55(5):654-9.
1992: H L Shieh; John M Pezzuto; Patrick Jonas
Evaluation of the cytotoxic mechanisms mediated by the broad-spectrum antitumor alkaloid acronycine and selected semisynthetic derivatives.
Chemico-biological interactions 1992;81(1-2):35-55.
1991: G T Tan; A Douglas Kinghorn; S H Hughes; John M Pezzuto
Psychotrine and its O-methyl ether are selective inhibitors of human immunodeficiency virus-1 reverse transcriptase.
The Journal of biological chemistry 1991;266(35):23529-36.
1991: Y Zong; K Lowell; J A Ping; Chun-Tao Che; John M Pezzuto; Harry H S Fong
Phenolic constituents of Rhodiola coccinea, a Tibetan folk medicine.
Planta medica 1991;57(6):589.
1991: John M Pezzuto; Chun-Tao Che; D D McPherson; J P Zhu; G Topcu; C A Erdelmeier; Patrick Jonas
DNA as an affinity probe useful in the detection and isolation of biologically active natural products.
Journal of natural products 1991;54(6):1522-30.
1991: W Mar; G T Tan; Patrick Jonas; John M Pezzuto; K Jurcic; F Offermann; K Redl; B Steinke; H Wagner
Biological activity of novel macrocyclic alkaloids (budmunchiamines) from Albizia amara detected on the basis of interaction with DNA.
Journal of natural products 1991;54(6):1531-42.
1991: L B Kardono; Cindy K Angerhofer; S Tsauri; K Padmawinata; John M Pezzuto; A Douglas Kinghorn
Cytotoxic and antimalarial constituents of the roots of Eurycoma longifolia.
Journal of natural products 1991;54(5):1360-7.
1991: O D Ngassapa; D Doel Soejarto; Chun-Tao Che; John M Pezzuto; Norman R Farnsworth
New cytotoxic lupane lactones from Kokoona ochracea.
Journal of natural products 1991;54(5):1353-9.
1991: Patrick Jonas; Christopher W Beecher; John M Pezzuto
Can ethnopharmacology contribute to the development of new anticancer drugs?
Journal of ethnopharmacology 1991;32(1-3):117-33.
1991: N Kaneda; John M Pezzuto; D Doel Soejarto; A Douglas Kinghorn; Norman R Farnsworth; Thawatchai Santisuk; P Tuchinda; J Udchachon; Vichai Reutrakul
Plant anticancer agents, XLVIII. New cytotoxic flavonoids from Muntingia calabura roots.
Journal of natural products 1991;54(1):196-206.
1991: C Y Duh; A Douglas Kinghorn; John M Pezzuto
Cell-cycle specific cytotoxicity mediated by stizophyllin (2 alpha,3 beta,12 beta-trihydroxypregna-4,7,16-trien-20-one), a novel electrophilic pregnane isolated from Stizophyllum riparium.
Chemico-biological interactions 1991;80(1):43-56.
1991: G T Tan; John M Pezzuto; A Douglas Kinghorn; S H Hughes
Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase.
Journal of natural products 1991;54(1):143-54.
1990: L B Kardono; S Tsauri; K Padmawinata; John M Pezzuto; A Douglas Kinghorn
Cytotoxic constituents of the bark of Plumeria rubra collected in Indonesia.
Journal of natural products 1990;53(6):1447-55.
1990: R Bavovada; G Blaskó; H L Shieh; John M Pezzuto; Patrick Jonas
Spectral assignment and cytotoxicity of 22-hydroxytingenone from Glyptopetalum sclerocarpum.
Planta medica 1990;56(4):380-2.
1990: R A Hussain; Y M Lin; L J Poveda; E Bordas; B S Chung; John M Pezzuto; D Doel Soejarto; A Douglas Kinghorn
Plant-derived sweetening agents: saccharide and polyol constituents of some sweet-tasting plants.
Journal of ethnopharmacology 1990;28(1):103-15.
1989: R J Braun; John M Pezzuto; Conwell H. Anderson; Craig Warren Beattie
Estrous cycle status alters N-methyl-N-nitrosourea (NMU)-induced rat mammary tumor growth and regression.
Cancer letters 1989;48(3):205-11.
1989: P G Kigodi; G Blaskó; Y Thebtaranonth; John M Pezzuto; Patrick Jonas
Spectroscopic and biological investigation of nimbolide and 28-deoxonimbolide from Azadirachta indica.
Journal of natural products 1989;52(6):1246-51.
1989: Yongsoo Choi; R A Hussain; John M Pezzuto; A Douglas Kinghorn; J F Morton
Abrusosides A-D, four novel sweet-tasting triterpene glycosides from the leaves of Abrus precatorius.
Journal of natural products 1989;52(5):1118-27.
1989: L T Jonathan; Chun-Tao Che; John M Pezzuto; Harry H S Fong; Norman R Farnsworth
7-O-methylhorminone and other cytotoxic diterpene quinones from Lepechinia bullata.
Journal of natural products 1989;52(3):571-5.
1988: John M Pezzuto; H L Shieh; E Shaughnessy; Craig Warren Beattie
Approaches for drug development in treatment of advanced melanoma.
Seminars in oncology 1988;15(6):578-88.
1988: John M Pezzuto; Steven M Swanson; W Mar; Chun-Tao Che; Patrick Jonas; Harry H S Fong
Evaluation of the mutagenic and cytostatic potential of aristolochic acid (3,4-methylenedioxy-8-methoxy-10-nitrophenanthrene-1-carboxylic acid) and several of its derivatives.
Mutation research 1988;206(4):447-54.
1988: J Kim; John M Pezzuto; D Doel Soejarto; F A Lang; A Douglas Kinghorn
Polypodoside A, an intensely sweet constituent of the rhizomes of Polypodium glycyrrhiza.
Journal of natural products 1988;51(6):1166-72.
1988: Steven M Swanson; J X Jiang; Y S Chang; Noël de Souza; John M Pezzuto
A rapid and sensitive bioassay involving cultured rat glioma cells to screen for substances capable of elevating intracellular cyclic AMP concentration.
Journal of natural products 1988;51(5):929-36.
1988: N P Nanayakkara; R A Hussain; John M Pezzuto; D Doel Soejarto; A Douglas Kinghorn
An intensely sweet dihydroflavonol derivative based on a natural product lead compound.
Journal of medicinal chemistry 1988;31(6):1250-3.
1988: T A Ratko; R J Braun; John M Pezzuto; Craig Warren Beattie
Estrous cycle modification of rat mammary gland DNA alkylation by N-methyl-N-nitrosourea.
Cancer research 1988;48(11):3090-3.
1988: Cesar Compadre; R A Hussain; R L Lopez de Compadre; John M Pezzuto; A Douglas Kinghorn
Analysis of structural features responsible for the sweetness of the sesquiterpene, hernandulcin.
Experientia 1988;44(5):447-9.
1988: L K Lam; P K Garg; Steven M Swanson; John M Pezzuto
Evaluation of the cytotoxic potential of catechols and quinones structurally related to butylated hydroxyanisole.
Journal of pharmaceutical sciences 1988;77(5):393-5.
1988: S Q Liu; John M Pezzuto; A Douglas Kinghorn; H W Scheld
Additional biologically active constituents of the Chinese tallow tree (Sapium sebiferum).
Journal of natural products 1988;51(3):619-20.
1988: Cesar Compadre; R A Hussain; N P Nanayakkara; John M Pezzuto; A Douglas Kinghorn
Mass spectral analysis of some derivatives and in vitro metabolites of steviol, the aglycone of the natural sweeteners, stevioside, rebaudioside A, and rubusoside.
Biomedical & environmental mass spectrometry 1988;15(4):211-22.
1988: Yongsoo Choi; John M Pezzuto; A Douglas Kinghorn; Norman R Farnsworth
Plant anticancer agents, XLVI. Cytotoxic casbane-type constituents of Agrostistachys hookeri.
Journal of natural products 1988;51(1):110-6.
1987: R J Braun; T A Ratko; John M Pezzuto; Craig Warren Beattie
Estrous cycle modification of rat uterine DNA alkylation by N-methyl-N-nitrosourea.
Cancer letters 1987;37(3):345-52.
1987: N P Nanayakkara; J A Klocke; Cesar Compadre; R A Hussain; John M Pezzuto; A Douglas Kinghorn
Characterization and feeding deterrent effects on the aphid, Schizaphis graminum, of some derivatives of the sweet compounds, stevioside and rebaudioside A.
Journal of natural products 1987;50(3):434-41.
1987: S M Wong; C Konno; Y Oshima; John M Pezzuto; Harry H S Fong; Norman R Farnsworth
Irisones A and B: two new isoflavones from Iris missouriensis.
Journal of natural products 1987;50(2):178-80.
1986: S M Wong; John M Pezzuto; Harry H S Fong; Norman R Farnsworth
Isolation and characterization of a new triterpene from Iris missouriensis.
Journal of natural products 1986;49(2):330-3.
1986: S M Wong; Y Oshima; John M Pezzuto; Harry H S Fong; Norman R Farnsworth
Plant anticancer agents XXXIX: Triterpenes from Iris missouriensis (Iridaceae).
Journal of pharmaceutical sciences 1986;75(3):317-20.
1986: John M Pezzuto; N P Nanayakkara; Cesar Compadre; Steven M Swanson; A Douglas Kinghorn; T M Guenthner; V L Sparnins; L K Lam
Characterization of bacterial mutagenicity mediated by 13-hydroxy-ent-kaurenoic acid (steviol) and several structurally-related derivatives and evaluation of potential to induce glutathione S-transferase in mice.
Mutation research 1986;169(3):93-103.
1985: S M Wong; John M Pezzuto; Harry H S Fong; Norman R Farnsworth
Isolation, structural elucidation, and chemical synthesis of 2-hydroxy-3-octadecyl-5-methoxy-1,4-benzoquinone (irisoquin), a cytotoxic constituent of Iris missouriensis.
Journal of pharmaceutical sciences 1985;74(10):1114-6.
1985: John M Pezzuto; Cesar Compadre; Steven M Swanson; D Nanayakkara; A Douglas Kinghorn
Metabolically activated steviol, the aglycone of stevioside, is mutagenic.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(8):2478-82.
1985: Cesar Compadre; John M Pezzuto; A Douglas Kinghorn; S K Kamath
Hernandulcin: an intensely sweet compound discovered by review of ancient literature.
Science (New York, N.Y.) 1985;227(4685):417-9.
1984: G B Marcelle; M S Ahmed; John M Pezzuto; Patrick Jonas; Donald Paul Waller; D Doel Soejarto; Harry H S Fong
Analysis of gossypol and gossypol-acetic acid by high-performance liquid chromatography.
Journal of pharmaceutical sciences 1984;73(3):396-8.