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Frank Abbott

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Jayakumar Surendradoss; Thomas K H Chang; Frank S Abbott
Assessment of the role of in situ generated (E)-2,4-diene-valproic acid in the toxicity of valproic acid and (E)-2-ene-valproic acid in sandwich-cultured rat hepatocytes.
Tony K L Kiang; Xiao Wei Teng; Jayakumar Surendradoss; Stoyan Karagiozov; Frank S Abbott; Thomas K H Chang
Glutathione depletion by valproic acid in sandwich-cultured rat hepatocytes: Role of biotransformation and temporal relationship with onset of toxicity.
Tony K L Kiang; Xiao Wei Teng; Stoyan Karagiozov; Jayakumar Surendradoss; Thomas K H Chang; Frank S Abbott
Role of oxidative metabolism in the effect of valproic acid on markers of cell viability, necrosis, and oxidative stress in sandwich-cultured rat hepatocytes.

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All Publications

2012: Jayakumar Surendradoss; Thomas K H Chang; Frank S Abbott
Assessment of the role of in situ generated (E)-2,4-diene-valproic acid in the toxicity of valproic acid and (E)-2-ene-valproic acid in sandwich-cultured rat hepatocytes.
Toxicology and applied pharmacology 2012;264(3):413-22.
2011: Tony K L Kiang; Xiao Wei Teng; Jayakumar Surendradoss; Stoyan Karagiozov; Frank S Abbott; Thomas K H Chang
Glutathione depletion by valproic acid in sandwich-cultured rat hepatocytes: Role of biotransformation and temporal relationship with onset of toxicity.
Toxicology and applied pharmacology 2011;252(3):318-24.
2010: Tony K L Kiang; Xiao Wei Teng; Stoyan Karagiozov; Jayakumar Surendradoss; Thomas K H Chang; Frank S Abbott
Role of oxidative metabolism in the effect of valproic acid on markers of cell viability, necrosis, and oxidative stress in sandwich-cultured rat hepatocytes.
Toxicological sciences : an official journal of the Society of Toxicology 2010;118(2):501-9.
2007: Andrew M Numa; Frank S Abbott; Thomas K H Chang
Effect of Ginkgo biloba extract on oxidative metabolism of valproic acid in hepatic microsomes from donors with the CYP2C9*1/*1 genotype.
Canadian journal of physiology and pharmacology 2007;85(9):848-55.
2007: Harvey Wong; Vincent Tong; K Wayne Riggs; Dan W Rurak; Frank S Abbott; Sanjeev Kumar
Kinetics of valproic acid glucuronidation: evidence for in vivo autoactivation.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(8):1380-6.
2006: Tony K L Kiang; Ping C Ho; M Reza Anari; Vincent Tong; Frank S Abbott; Thomas K H Chang
Contribution of CYP2C9, CYP2A6, and CYP2B6 to valproic acid metabolism in hepatic microsomes from individuals with the CYP2C9*1/*1 genotype.
Toxicological sciences : an official journal of the Society of Toxicology 2006;94(2):261-71.
2006: Aspasia Michoulas; Vincent Tong; Xiao Wei Teng; Thomas K H Chang; Frank S Abbott; Kevin Farrell
Oxidative stress in children receiving valproic acid.
The Journal of pediatrics 2006;149(5):692-6.
2006: Thomas K H Chang; Frank S Abbott
Oxidative stress as a mechanism of valproic acid-associated hepatotoxicity.
Drug metabolism reviews 2006;38(4):627-39.
2005: Vincent Tong; Xiao Wei Teng; Thomas K H Chang; Frank S Abbott
Valproic acid I: time course of lipid peroxidation biomarkers, liver toxicity, and valproic acid metabolite levels in rats.
Toxicological sciences : an official journal of the Society of Toxicology 2005;86(2):427-35.
2005: Vincent Tong; Xiao Wei Teng; Thomas K H Chang; Frank S Abbott
Valproic acid II: effects on oxidative stress, mitochondrial membrane potential, and cytotoxicity in glutathione-depleted rat hepatocytes.
Toxicological sciences : an official journal of the Society of Toxicology 2005;86(2):436-43.
2005: Vincent Tong; Xiao Wei Teng; Stoyan Karagiozov; Thomas K H Chang; Frank S Abbott
Valproic acid glucuronidation is associated with increases in 15-F2t-isoprostane in rats.
Free radical biology & medicine 2005;38(11):1471-83.
2003: Vincent Tong; Thomas K H Chang; Jie Chen; Frank S Abbott
The effect of valproic acid on hepatic and plasma levels of 15-F2t-isoprostane in rats.
Free radical biology & medicine 2003;34(11):1435-46.
2003: Sashi Gopaul; Kevin Farrell; Frank S Abbott
Effects of age and polytherapy, risk factors of valproic acid (VPA) hepatotoxicity, on the excretion of thiol conjugates of (E)-2,4-diene VPA in people with epilepsy taking VPA.
Epilepsia 2003;44(3):322-8.
2003: P C Ho; Frank S Abbott; Uli Zanger; Thomas K H Chang
Influence of CYP2C9 genotypes on the formation of a hepatotoxic metabolite of valproic acid in human liver microsomes.
The pharmacogenomics journal 2003;3(6):335-42.
2003: V S Gopaul; W Tang; Kevin Farrell; Frank S Abbott
Amino acid conjugates: metabolites of 2-propylpentanoic acid (valproic acid) in epileptic patients.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(1):114-21.
2001: Vincent Tong; T Sheng; M J Walker; Frank S Abbott
Determination of an arylether antiarrhythmic and its N-dealkyl metabolite in rat plasma and hepatic microsomal incubates using liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Biomedical sciences and applications 2001;759(2):259-66.
2001: Harvey Wong; Dan W Rurak; S Kumar; Eddie Kwan; Frank S Abbott; K Wayne Riggs
Dose-dependent pharmacokinetics and metabolism of valproic acid in newborn lambs and adult sheep.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(5):664-75.
2001: Vincent Tong; Frank S Abbott; S Mbofana; M J Walker
In vitro investigation of the hepatic extraction of RSD1070, a novel antiarrhythmic compound.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Société canadienne des sciences pharmaceutiques 2001;4(1):15-23.
2000: Harvey Wong; S Kumar; Dan W Rurak; Eddie Kwan; Frank S Abbott; K Wayne Riggs
Ontogeny of valproic acid disposition and metabolism: a developmental study in postnatal lambs and adult sheep.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(8):912-9.
2000: S Kumar; Harvey Wong; S A Yeung; K Wayne Riggs; Frank S Abbott; Dan W Rurak
Disposition of valproic acid in maternal, fetal, and newborn sheep. II: metabolism and renal elimination.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(7):857-64.
2000: S Kumar; Harvey Wong; S A Yeung; K Wayne Riggs; Frank S Abbott; Dan W Rurak
Disposition of valproic acid in maternal, fetal, and newborn sheep. I: placental transfer, plasma protein binding, and clearance.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(7):845-56.
2000: Sashi Gopaul; Kevin Farrell; Frank S Abbott
Identification and characterization of N-acetylcysteine conjugates of valproic acid in humans and animals.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(7):823-32.
2000: M R Anari; R W Burton; Sashi Gopaul; Frank S Abbott
Metabolic profiling of valproic acid by cDNA-expressed human cytochrome P450 enzymes using negative-ion chemical ionization gas chromatography-mass spectrometry.
Journal of chromatography. B, Biomedical sciences and applications 2000;742(2):217-27.
2000: Sashi Gopaul; Kevin Farrell; Frank S Abbott
Gas chromatography/negative ion chemical ionization mass spectrometry and liquid chromatography/electrospray ionization tandem mass spectrometry quantitative profiling of N-acetylcysteine conjugates of valproic acid in urine: application in drug metabolism studies in humans.
Journal of mass spectrometry : JMS 2000;35(6):698-704.
1999: AR Tabatabaei; Frank S Abbott
LC/MS analysis of hydroxylation products of salicylate as an indicator of in vivo oxidative stress.
Free radical biology & medicine 1999;26(7-8):1054-8.
1999: AR Tabatabaei; RL Thies; Frank S Abbott
Assessing the mechanism of metabolism-dependent valproic acid-induced in vitro cytotoxicity.
Chemical research in toxicology 1999;12(4):323-30.
1997: W Tang; Jan Palaty; Frank S Abbott
Time course of alpha-fluorinated valproic acid in mouse brain and serum and its effect on synaptosomal gamma-aminobutyric acid levels in comparison to valproic acid.
The Journal of pharmacology and experimental therapeutics 1997;282(3):1163-72.
1997: AR Tabatabaei; RL Thies; Kevin Farrell; Frank S Abbott
A rapid in vitro assay for evaluation of metabolism-dependent cytotoxicity of antiepileptic drugs on isolated human lymphocytes.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1997;37(2):181-9.
1997: W Tang; Frank S Abbott
A comparative investigation of 2-propyl-4-pentenoic acid (4-ene VPA) and its alpha-fluorinated analogue: phase II metabolism and pharmacokinetics.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(2):219-27.
1996: W Tang; Frank S Abbott
Characterization of thiol-conjugated metabolites of 2-propylpent-4-enoic acid (4-ene VPA), a toxic metabolite of valproic acid, by electrospray tandem mass spectrometry.
Journal of mass spectrometry : JMS 1996;31(8):926-36.
1996: S K Panesar; Stelvio M Bandiera; Frank S Abbott
Comparative effects of carbamazepine and carbamazepine-10,11-epoxide on hepatic cytochromes P450 in the rat.
Drug metabolism and disposition: the biological fate of chemicals 1996;24(6):619-27.
1996: W Tang; A G Borel; Frank S Abbott
Conjugation of glutathione with a toxic metabolite of valproic acid, (E)-2-propyl-2,4-pentadienoic acid, catalyzed by rat hepatic glutathione-S-transferases.
Drug metabolism and disposition: the biological fate of chemicals 1996;24(4):436-46.
1996: W Tang; Frank S Abbott
Bioactivation of a toxic metabolite of valproic acid, (E)-2-propyl-2,4-pentadienoic acid, via glucuronidation. LC/MS/MS characterization of the GSH-glucuronide diconjugates.
Chemical research in toxicology 1996;9(2):517-26.
1995: J D Gordon; K Wayne Riggs; Dan W Rurak; E Kwan; C Hall; Frank S Abbott
The pharmacokinetics of valproic acid in pregnant sheep after maternal and fetal intravenous bolus administration.
Drug metabolism and disposition: the biological fate of chemicals 1995;23(12):1383-9.
1995: A G Borel; Frank S Abbott
Characterization of novel isocyanate-derived metabolites of the formamide N-formylamphetamine with the combined use of electrospray mass spectrometry and stable isotope methodology.
Chemical research in toxicology 1995;8(6):891-9.
1995: J Palaty; Frank S Abbott
Structure-activity relationships of unsaturated analogues of valproic acid.
Journal of medicinal chemistry 1995;38(17):3398-406.
1995: W Tang; A G Borel; T Fujimiya; Frank S Abbott
Fluorinated analogues as mechanistic probes in valproic acid hepatotoxicity: hepatic microvesicular steatosis and glutathione status.
Chemical research in toxicology 1995;8(5):671-82.
1995: D Yu; J D Gordon; J Zheng; S K Panesar; K Wayne Riggs; Dan W Rurak; Frank S Abbott
Determination of valproic acid and its metabolites using gas chromatography with mass-selective detection: application to serum and urine samples from sheep.
Journal of chromatography. B, Biomedical applications 1995;666(2):269-81.
1995: GR Tonn; Frank S Abbott; Dan W Rurak; J E Axelson
Simultaneous analysis of diphenylmethoxyacetic acid, a metabolite of diphenhydramine, and its deuterium-labeled stable isotope analog in ovine plasma and urine.
Journal of chromatography. B, Biomedical applications 1995;663(1):67-81.
1995: GR Tonn; A Doroudian; J G Gordon; Dan W Rurak; K Wayne Riggs; Frank S Abbott; J E Axelson
New approaches for drug and kinetic analysis in the maternal-fetal unit.
NIDA research monograph 1995;154():175-202.
1994: J Palaty; R Burton; Frank S Abbott
Rapid assay for gamma-aminobutyric acid in mouse brain synaptosomes using gas chromatography-mass spectrometry.
Journal of chromatography. B, Biomedical applications 1994;662(1):85-90.
1994: K Wayne Riggs; A Szeitz; Dan W Rurak; A E Mutlib; Frank S Abbott; J E Axelson
Determination of metoclopramide and two of its metabolites using a sensitive and selective gas chromatographic-mass spectrometric assay.
Journal of chromatography. B, Biomedical applications 1994;660(2):315-25.
1993: GR Tonn; A Mutlib; Frank S Abbott; Dan W Rurak; J E Axelson
Simultaneous analysis of diphenhydramine and a stable isotope analog (2H10)diphenhydramine using capillary gas chromatography with mass selective detection in biological fluids from chronically instrumented pregnant ewes.
Biological mass spectrometry 1993;22(11):633-42.
1993: K Yeleswaram; Dan W Rurak; E Kwan; C Hall; A Doroudian; M R Wright; Frank S Abbott; J E Axelson
Transplacental and nonplacental clearances, metabolism and pharmacodynamics of labetalol in the fetal lamb after direct intravenous administration.
The Journal of pharmacology and experimental therapeutics 1993;267(1):425-31.
1993: A Doroudian; K Yeleswaram; Dan W Rurak; Frank S Abbott; J E Axelson
Sensitive high-performance liquid chromatographic method for direct separation of labetalol stereoisomers in biological fluids using an alpha 1-acid glycoprotein stationary phase.
Journal of chromatography 1993;619(1):79-86.
1993: A G Borel; Frank S Abbott
Identification of carbamoylated thiol conjugates as metabolites of the antineoplastic 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea, in rats and humans.
Drug metabolism and disposition: the biological fate of chemicals 1993;21(5):889-901.
1993: A G Borel; Frank S Abbott
Metabolic profiling of clobazam, a 1,5-benzodiazepine, in rats.
Drug metabolism and disposition: the biological fate of chemicals 1993;21(3):415-27.
1993: K Yeleswaram; Dan W Rurak; E Kwan; C Hall; A Doroudian; Frank S Abbott; J E Axelson
Disposition, metabolism, and pharmacodynamics of labetalol in adult sheep.
Drug metabolism and disposition: the biological fate of chemicals 1993;21(2):284-92.
1992: K Yeleswaram; Dan W Rurak; E Kwan; C Hall; Frank S Abbott; J E Axelson
Identification and quantitation of an oxidative metabolite of labetalol in sheep: pharmacokinetic and metabolic implications.
Biological mass spectrometry 1992;21(11):534-40.
1992: A E Mutlib; Y C Chui; L M Young; Frank S Abbott
Characterization of metabolites of xylazine produced in vivo and in vitro by LC/MS/MS and by GC/MS.
Drug metabolism and disposition: the biological fate of chemicals 1992;20(6):840-8.
1992: A E Mutlib; Frank S Abbott
Isolation and characterization of carbinolamide and phenolic glucuronide conjugates of (+-)-N-methyl-N-(1-methyl-3,3-diphenylpropyl) formamide and N-formylmethamphetamine by FAB/MS, LC/MS/MS, and NMR.
Drug metabolism and disposition: the biological fate of chemicals 1992;20(3):451-60.
1991: M R Wright; J E Axelson; Frank S Abbott; K Wayne Riggs; M P Van der Weyde; S M Taylor; G H McMorland; Dan W Rurak
Determination of ritodrine in biological fluids of the pregnant sheep by fused-silica capillary gas chromatography using electron-capture detection.
Journal of chromatography 1991;565(1-2):225-36.
1990: A E Mutlib; rasmy e talaat; J Greg Slatter; Frank S Abbott
Formation and reversibility of S-linked conjugates of N-(1-methyl-3,3-diphenylpropyl)isocyanate, an in vivo metabolite of N-(1-methyl-3,3-diphenylpropyl)formamaide, in rats.
Drug metabolism and disposition: the biological fate of chemicals 1990;18(6):1038-45.
1990: K Singh; J M Orr; Frank S Abbott
Pharmacokinetics and enterohepatic circulation of (E)-2-ene valproic acid in the rat.
Journal of pharmacobio-dynamics 1990;13(10):622-7.
1990: J Greg Slatter; Frank S Abbott; R Burton
Identification of the biliary metabolites of (+/-)-3-dimethylamino-1,1-diphenylbutane HCl (recipavrin) in rats.
Xenobiotica; the fate of foreign compounds in biological systems 1990;20(10):999-1024.
1989: GL Chan; J E Axelson; Frank S Abbott; K M McErlane; Charles R Kerr
Determination of 5-hydroxypropafenone in biological fluids by fused-silica capillary gas chromatography using electron-capture detection.
Journal of chromatography 1989;495():349-53.
1989: K Kassahun; R Burton; Frank S Abbott
Negative ion chemical ionization gas chromatography/mass spectrometry of valproic acid metabolites.
Biomedical & environmental mass spectrometry 1989;18(10):918-26.
1989: J Greg Slatter; A E Mutlib; Frank S Abbott
Biotransformation of aliphatic formamides: metabolites of (+-)-N-methyl-N-(1-methyl-3,3-diphenylpropyl) formamide in rats.
Biomedical & environmental mass spectrometry 1989;18(9):690-701.
1989: R D Lee; K Kassahun; Frank S Abbott
Stereoselective synthesis of the diunsaturated metabolites of valproic acid.
Journal of pharmaceutical sciences 1989;78(8):667-71.
1989: S K Panesar; J M Orr; Kevin Farrell; R W Burton; K Kassahun; Frank S Abbott
The effect of carbamazepine on valproic acid disposition in adult volunteers.
British journal of clinical pharmacology 1989;27(3):323-8.
1988: K Singh; J M Orr; Frank S Abbott
Pharmacokinetics and enterohepatic circulation of 2-n-propyl-4-pentenoic acid in the rat.
Drug metabolism and disposition: the biological fate of chemicals 1988;16(6):848-52.
1988: Frank S Abbott; A A Acheampong
Quantitative structure-anticonvulsant activity relationships of valproic acid, related carboxylic acids and tetrazoles.
Neuropharmacology 1988;27(3):287-94.
1987: GL Chan; J E Axelson; Frank S Abbott; Charles R Kerr; K M McErlane
Determination of propafenone in biological fluids by fused-silica capillary gas chromatography using electron-capture detection.
Journal of chromatography 1987;417(2):295-308.
1987: K Singh; Frank S Abbott; J M Orr
Capillary GCMS assay of 2-n-propyl-4-pentenoic acid (4-ene VPA) in rat plasma and urine.
Research communications in chemical pathology and pharmacology 1987;56(2):211-23.
1986: Frank S Abbott; J Kassam; A Acheampong; S Ferguson; S Panesar; R Burton; Kevin Farrell; J Orr
Capillary gas chromatography-mass spectrometry of valproic acid metabolites in serum and urine using tert.-butyldimethylsilyl derivatives.
Journal of chromatography 1986;375(2):285-98.
1985: Frank S Abbott; J Greg Slatter; R Burton; G I Kang
Methadone metabolism in the rat in vivo: identification of a novel formamide metabolite.
Xenobiotica; the fate of foreign compounds in biological systems 1985;15(2):129-40.
1984: R P Kapil; Frank S Abbott; Charles R Kerr; David J Edwards; D Lalka; J E Axelson
Simultaneous quantitation of disopyramide and its mono-dealkylated metabolite in human plasma by fused-silica capillary gas chromatography using nitrogen-phosphorus specific detection.
Journal of chromatography 1984;307(2):305-21.
1984: A A Acheampong; Frank S Abbott; J M Orr; S M Ferguson; R W Burton
Use of hexadeuterated valproic acid and gas chromatography-mass spectrometry to determine the pharmacokinetics of valproic acid.
Journal of pharmaceutical sciences 1984;73(4):489-94.
1982: G I Kang; Frank S Abbott
Analysis of methadone and metabolites in biological fluids with gas chromatography--mass spectrometry.
Journal of chromatography 1982;231(2):311-9.
1982: R Venkataramanan; Frank S Abbott; J E Axelson
Metabolism of tocainide in the rat.
Journal of pharmaceutical sciences 1982;71(5):491-4.
1982: Frank S Abbott; R Burton; J Orr; D Wladichuk; S Ferguson; T H Sun
Valproic acid analysis in saliva and serum using selected ion monitoring (electron ionization) of the tert.-butyldimethylsilyl derivatives.
Journal of chromatography 1982;227(2):433-44.
1981: D S Au; J O Runikis; Frank S Abbott; R W Burton
GLC analysis of hydrocortisone, triamcinolone acetonide, and desonide in culture media of mouse and human dermal fibroblasts using flame-ionization detection.
Journal of pharmaceutical sciences 1981;70(8):917-23.