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Magnus Pfahl

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Kyung-Hee Chun; Magnus Pfahl; Reuben Lotan
Induction of apoptosis by the synthetic retinoid MX3350-1 through extrinsic and intrinsic pathways in head and neck squamous carcinoma cells.
Magnus Pfahl; F Javier Piedrafita
Retinoid targets for apoptosis induction.
Yolanda Bayon; Maria A Ortiz; Francisco J Lopez-Hernandez; Feng Gao; Michael Karin; Magnus Pfahl; F Javier Piedrafita
Inhibition of IkappaB kinase by a new class of retinoid-related anticancer agents that induce apoptosis.

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All Publications

2005: Kyung-Hee Chun; Magnus Pfahl; Reuben Lotan
Induction of apoptosis by the synthetic retinoid MX3350-1 through extrinsic and intrinsic pathways in head and neck squamous carcinoma cells.
Oncogene 2005;24(22):3669-77.
2003: Magnus Pfahl; F Javier Piedrafita
Retinoid targets for apoptosis induction.
Oncogene 2003;22(56):9058-62.
2003: Yolanda Bayon; Maria A Ortiz; Francisco J Lopez-Hernandez; Feng Gao; Michael Karin; Magnus Pfahl; F Javier Piedrafita
Inhibition of IkappaB kinase by a new class of retinoid-related anticancer agents that induce apoptosis.
Molecular and cellular biology 2003;23(3):1061-74.
2001: Maria A Ortiz; Francisco J Lopez-Hernandez; Yolanda Bayon; Magnus Pfahl; F Javier Piedrafita
Retinoid-related molecules induce cytochrome c release and apoptosis through activation of c-Jun NH(2)-terminal kinase/p38 mitogen-activated protein kinases.
Cancer research 2001;61(23):8504-12.
1999: XP Lu; AN Fanjul; N Picard; B Shroot; Magnus Pfahl
A selective retinoid with high activity against an androgen-resistant prostate cancer cell type.
International journal of cancer. Journal international du cancer 1999;80(2):272-8.
1998: J Y Hsu; Magnus Pfahl
ET-1 expression and growth inhibition of prostate cancer cells: a retinoid target with novel specificity.
Cancer research 1998;58(21):4817-22.
1998: AN Fanjul; F Javier Piedrafita; H Al-Shamma; Magnus Pfahl
Apoptosis induction and potent antiestrogen receptor-negative breast cancer activity in vivo by a retinoid antagonist.
Cancer research 1998;58(20):4607-10.
1998: S V Yarovoi; XP Lu; N Picard; D Rungta; D Rideout; Magnus Pfahl
Selective activation of an apoptotic retinoid precursor in macrophage cell lines.
The Journal of biological chemistry 1998;273(33):20852-9.
1998: Magnus Pfahl
Retinoid related molecules: new promises against lung and breast cancer.
Expert opinion on investigational drugs 1998;7(4):601-6.
1997: F Javier Piedrafita; Magnus Pfahl
Retinoid-induced apoptosis and Sp1 cleavage occur independently of transcription and require caspase activation.
Molecular and cellular biology 1997;17(11):6348-58.
1997: XP Lu; AN Fanjul; N Picard; Magnus Pfahl; D Rungta; K Nared-Hood; B Carter; J Piedrafita; S Tang; E Fabbrizio; M Pfahl
Novel retinoid-related molecules as apoptosis inducers and effective inhibitors of human lung cancer cells in vivo.
Nature medicine 1997;3(6):686-90.
1996: A N Fanjul; D Delia; M A Pierotti; D Rideout; J Q Yu; Magnus Pfahl; J Qiu
4-Hydroxyphenyl retinamide is a highly selective activator of retinoid receptors.
The Journal of biological chemistry 1996;271(37):22441-6.
1996: N La Vista-Picard; Peter D Hobbs; Magnus Pfahl; Marcia I Dawson; M Pfahl
The receptor-DNA complex determines the retinoid response: a mechanism for the diversification of the ligand signal.
Molecular and cellular biology 1996;16(8):4137-46.
1996: F Javier Piedrafita; R B Molander; G Vansant; E A Orlova; Magnus Pfahl; W F Reynolds
An Alu element in the myeloperoxidase promoter contains a composite SP1-thyroid hormone-retinoic acid response element.
The Journal of biological chemistry 1996;271(24):14412-20.
1996: M O Lee; Marcia I Dawson; N Picard; Peter D Hobbs; Magnus Pfahl
A novel class of retinoid antagonists and their mechanism of action.
The Journal of biological chemistry 1996;271(20):11897-903.
1996: A N Fanjul; H Bouterfa; M Dawson; Magnus Pfahl
Potential role for retinoic acid receptor-gamma in the inhibition of breast cancer cells by selective retinoids and interferons.
Cancer research 1996;56(7):1571-7.
1995: M A Ortiz; F Javier Piedrafita; Magnus Pfahl; R Maki
TOR: a new orphan receptor expressed in the thymus that can modulate retinoid and thyroid hormone signals.
Molecular endocrinology (Baltimore, Md.) 1995;9(12):1679-91.
1995: F Javier Piedrafita; M A Ortiz; Magnus Pfahl
Thyroid hormone receptor-beta mutants associated with generalized resistance to thyroid hormone show defects in their ligand-sensitive repression function.
Molecular endocrinology (Baltimore, Md.) 1995;9(11):1533-48.
1995: H L Bouterfa; F Javier Piedrafita; Detlef Doenecke; Magnus Pfahl
Regulation of H1(0) gene expression by nuclear receptors through an unusual response element: implications for regulation of cell proliferation.
DNA and cell biology 1995;14(11):909-19.
1995: Marcia I Dawson; Ling Jong; Peter D Hobbs; J F Cameron; Wan-Ru Chao; Magnus Pfahl; M O Lee; B Shroot; M Pfahl
Conformational effects on retinoid receptor selectivity. 2. Effects of retinoid bridging group on retinoid X receptor activity and selectivity.
Journal of medicinal chemistry 1995;38(17):3368-83.
1995: F Javier Piedrafita; I Bendik; M A Ortiz; Magnus Pfahl
Thyroid hormone receptor homodimers can function as ligand-sensitive repressors.
Molecular endocrinology (Baltimore, Md.) 1995;9(5):563-78.
1995: I Bendik; Magnus Pfahl
Similar ligand-induced conformational changes of thyroid hormone receptors regulate homo- and heterodimeric functions.
The Journal of biological chemistry 1995;270(7):3107-14.
1994: X P Lu; G Salbert; Magnus Pfahl
An evolutionary conserved COUP-TF binding element in a neural-specific gene and COUP-TF expression patterns support a major role for COUP-TF in neural development.
Molecular endocrinology (Baltimore, Md.) 1994;8(12):1774-88.
1994: A Fanjul; Marcia I Dawson; Peter D Hobbs; Ling Jong; J F Cameron; E Harlev; G Graupner; X P Lu; Magnus Pfahl
A new class of retinoids with selective inhibition of AP-1 inhibits proliferation.
Nature 1994;372(6501):107-11.
1994: Xiao-kun Zhang; Y Liu; M O Lee; Magnus Pfahl
A specific defect in the retinoic acid response associated with human lung cancer cell lines.
Cancer research 1994;54(21):5663-9.
1994: R Apfel; D Benbrook; E Lernhardt; M A Ortiz; G Salbert; Magnus Pfahl
A novel orphan receptor specific for a subset of thyroid hormone-responsive elements and its interaction with the retinoid/thyroid hormone receptor subfamily.
Molecular and cellular biology 1994;14(10):7025-35.
1994: M O Lee; Peter D Hobbs; Xiao-kun Zhang; Marcia I Dawson; Magnus Pfahl
A synthetic retinoid antagonist inhibits the human immunodeficiency virus type 1 promoter.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(12):5632-6.
1994: Xiao-kun Zhang; G Salbert; M O Lee; Magnus Pfahl
Mutations that alter ligand-induced switches and dimerization activities in the retinoid X receptor.
Molecular and cellular biology 1994;14(6):4311-23.
1994: A Lombardo; E Costa; Wan-Ru Chao; L Toll; Peter D Hobbs; Ling Jong; M O Lee; Magnus Pfahl; Kathryn R Ely; Marcia I Dawson
Recombinant human retinoic acid receptor beta. Binding of synthetic retinoids and transcriptional activation.
The Journal of biological chemistry 1994;269(10):7297-303.
1994: Xiao-kun Zhang; Magnus Pfahl
Molecular mechanisms of action for vitamin A-derived hormones.
Progress in clinical and biological research 1994;387():59-71.
1994: Magnus Pfahl; R Apfel; I Bendik; A Fanjul; G Graupner; M O Lee; N La-Vista; X P Lu; J Piedrafita; M A Ortiz
Nuclear retinoid receptors and their mechanism of action.
Vitamins and hormones 1994;49():327-82.
1993: Jurgen Lehmann; Xiao-kun Zhang; G Graupner; M O Lee; T Hermann; B Hoffmann; Magnus Pfahl
Formation of retinoid X receptor homodimers leads to repression of T3 response: hormonal cross talk by ligand-induced squelching.
Molecular and cellular biology 1993;13(12):7698-707.
1993: X P Lu; N L Eberhardt; Magnus Pfahl
DNA bending by retinoid X receptor-containing retinoid and thyroid hormone receptor complexes.
Molecular and cellular biology 1993;13(10):6509-19.
1993: G Salbert; A Fanjul; F Javier Piedrafita; X P Lu; S J Kim; P Tran; Magnus Pfahl
Retinoic acid receptors and retinoid X receptor-alpha down-regulate the transforming growth factor-beta 1 promoter by antagonizing AP-1 activity.
Molecular endocrinology (Baltimore, Md.) 1993;7(10):1347-56.
1993: Magnus Pfahl
Nuclear receptor/AP-1 interaction.
Endocrine reviews 1993;14(5):651-8.
1993: Ling Jong; Jurgen Lehmann; Peter D Hobbs; E Harlev; J C Huffman; Magnus Pfahl; Marcia I Dawson
Conformational effects on retinoid receptor selectivity. 1. Effect of 9-double bond geometry on retinoid X receptor activity.
Journal of medicinal chemistry 1993;36(18):2605-13.
1993: Xiao-kun Zhang; Magnus Pfahl
Hetero- and homodimeric receptors in thyroid hormone and vitamin A action.
Receptor 1993;3(3):183-91.
1993: Magnus Pfahl
Signal transduction by retinoid receptors.
Skin pharmacology : the official journal of the Skin Pharmacology Society 1993;6 Suppl 1():8-16.
1993: T Hermann; B Hoffmann; F Javier Piedrafita; X K Zhang; Magnus Pfahl
V-erbA requires auxiliary proteins for dominant negative activity.
Oncogene 1993;8(1):55-65.
1992: Jurgen Lehmann; Ling Jong; A Fanjul; J F Cameron; X P Lu; P Haefner; Marcia I Dawson; Magnus Pfahl
Retinoids selective for retinoid X receptor response pathways.
Science (New York, N.Y.) 1992;258(5090):1944-6.
1992: P Tran; Xiao-kun Zhang; G Salbert; T Hermann; Jurgen Lehmann; Magnus Pfahl
COUP orphan receptors are negative regulators of retinoic acid response pathways.
Molecular and cellular biology 1992;12(10):4666-76.
1992: M Husmann; B Hoffmann; D G Stump; F Chytil; Magnus Pfahl
A retinoic acid response element from the rat CRBPI promoter is activated by an RAR/RXR heterodimer.
Biochemical and biophysical research communications 1992;187(3):1558-64.
1992: Xiao-kun Zhang; J Lehmann; B Hoffmann; Marcia I Dawson; J Cameron; G Graupner; T Hermann; P Tran; Magnus Pfahl
Homodimer formation of retinoid X receptor induced by 9-cis retinoic acid.
Nature 1992;358(6387):587-91.
1992: T Hermann; B Hoffmann; Xiao-kun Zhang; P Tran; Magnus Pfahl
Heterodimeric receptor complexes determine 3,5,3'-triiodothyronine and retinoid signaling specificities.
Molecular endocrinology (Baltimore, Md.) 1992;6(7):1153-62.
1992: Jurgen Lehmann; Xiao-kun Zhang; Magnus Pfahl
RAR gamma 2 expression is regulated through a retinoic acid response element embedded in Sp1 sites.
Molecular and cellular biology 1992;12(7):2976-85.
1992: Xiao-kun Zhang; B Hoffmann; P B Tran; G Graupner; Magnus Pfahl
Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptors.
Nature 1992;355(6359):441-6.
1991: Xiao-kun Zhang; K N Wills; M Husmann; T Hermann; Magnus Pfahl
Novel pathway for thyroid hormone receptor action through interaction with jun and fos oncogene activities.
Molecular and cellular biology 1991;11(12):6016-25.
1991: M Tzukerman; Xiao-kun Zhang; Magnus Pfahl
Inhibition of estrogen receptor activity by the tumor promoter 12-O-tetradeconylphorbol-13-acetate: a molecular analysis.
Molecular endocrinology (Baltimore, Md.) 1991;5(12):1983-92.
1991: Xiao-kun Zhang; P B Tran; Magnus Pfahl
DNA binding and dimerization determinants for thyroid hormone receptor alpha and its interaction with a nuclear protein.
Molecular endocrinology (Baltimore, Md.) 1991;5(12):1909-20.
1991: H F Yang-Yen; Xiao-kun Zhang; G Graupner; M Tzukerman; B Sakamoto; Michael Karin; Magnus Pfahl
Antagonism between retinoic acid receptors and AP-1: implications for tumor promotion and inflammation.
The New biologist 1991;3(12):1206-19.
1991: R Haq; Magnus Pfahl; F Chytil
Differential effects of all-trans and 13-cis-retinoic acid on mRNA levels of nuclear retinoic acid receptors in rat lung and liver.
Biochemical and biophysical research communications 1991;180(2):1137-44.
1991: G Graupner; G Malle; J Maignan; G Lang; M Pruniéras; Magnus Pfahl
6'-substituted naphthalene-2-carboxylic acid analogs, a new class of retinoic acid receptor subtype-specific ligands.
Biochemical and biophysical research communications 1991;179(3):1554-61.
1991: R Haq; Magnus Pfahl; F Chytil
Retinoic acid affects the expression of nuclear retinoic acid receptors in tissues of retinol-deficient rats.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(18):8272-6.
1991: Jurgen Lehmann; Marcia I Dawson; Peter D Hobbs; M Husmann; Magnus Pfahl
Identification of retinoids with nuclear receptor subtype-selective activities.
Cancer research 1991;51(18):4804-9.
1991: K N Wills; Xiao-kun Zhang; Magnus Pfahl
Coordinate expression of functionally distinct thyroid hormone receptor alpha isoforms during neonatal brain development.
Molecular endocrinology (Baltimore, Md.) 1991;5(8):1109-19.
1991: M Husmann; J Lehmann; B Hoffmann; T Hermann; M Tzukerman; Magnus Pfahl
Antagonism between retinoic acid receptors.
Molecular and cellular biology 1991;11(8):4097-103.
1991: T Hermann; Xiao-kun Zhang; M Tzukerman; K N Wills; G Graupner; Magnus Pfahl
Regulatory functions of a non-ligand-binding thyroid hormone receptor isoform.
Cell regulation 1991;2(7):565-74.
1991: G Graupner; Xiao-kun Zhang; M Tzukerman; K Wills; T Hermann; Magnus Pfahl
Thyroid hormone receptors repress estrogen receptor activation of a TRE.
Molecular endocrinology (Baltimore, Md.) 1991;5(3):365-72.
1991: Jurgen Lehmann; B Hoffmann; Magnus Pfahl
Genomic organization of the retinoic acid receptor gamma gene.
Nucleic acids research 1991;19(3):573-8.
1991: Xiao-kun Zhang; K N Wills; G Graupner; M Tzukerman; T Hermann; Magnus Pfahl
Ligand-binding domain of thyroid hormone receptors modulates DNA binding and determines their bifunctional roles.
The New biologist 1991;3(2):169-81.
1990: B Hoffmann; Jurgen Lehmann; Xiao-kun Zhang; T Hermann; M Husmann; G Graupner; Magnus Pfahl
A retinoic acid receptor-specific element controls the retinoic acid receptor-beta promoter.
Molecular endocrinology (Baltimore, Md.) 1990;4(11):1727-36.
1990: M Tzukerman; Xiao-kun Zhang; T Hermann; K N Wills; G Graupner; Magnus Pfahl
The human estrogen receptor has transcriptional activator and repressor functions in the absence of ligand.
The New biologist 1990;2(7):613-20.
1990: Magnus Pfahl; M Tzukerman; Xiao-kun Zhang; Jurgen Lehmann; T Hermann; K N Wills; G Graupner
Nuclear retinoic acid receptors: cloning, analysis, and function.
Methods in enzymology 1990;189():256-70.
1989: G Graupner; K N Wills; M Tzukerman; Xiao-kun Zhang; Magnus Pfahl
Dual regulatory role for thyroid-hormone receptors allows control of retinoic-acid receptor activity.
Nature 1989;340(6235):653-6.
1988: K C Wu; Magnus Pfahl
Variable responsiveness of hormone-inducible hybrid genes in different cell lines.
Molecular endocrinology (Baltimore, Md.) 1988;2(12):1294-301.
1988: D Benbrook; E Lernhardt; Magnus Pfahl
A new retinoic acid receptor identified from a hepatocellular carcinoma.
Nature 1988;333(6174):669-72.
1987: Magnus Pfahl; D Benbrook
Nucleotide sequence of cDNA encoding a novel human thyroid hormone receptor.
Nucleic acids research 1987;15(22):9613.
1987: D Benbrook; Magnus Pfahl
A novel thyroid hormone receptor encoded by a cDNA clone from a human testis library.
Science (New York, N.Y.) 1987;238(4828):788-91.