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Nikolaus Pfanner

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Nils Wiedemann; Sebastian B Stiller; Nikolaus Pfanner
Activation and degradation of mitofusins: two pathways regulate mitochondrial fusion by reversible ubiquitylation.
Lena Böttinger; Günther Daum; Susanne E Horvath; Carola Hunte; Thomas Kleinschroth; Nikolaus Pfanner; Thomas Becker
Phosphatidylethanolamine and cardiolipin differentially affect the stability of mitochondrial respiratory chain supercomplexes.
Maria Bohnert; Agnieszka Chacinska; Günther Daum; Susanne E Horvath; Judith M Müller; Silke Oeljeklaus; Inge Perschil; Nikolaus Pfanner; David A Stroud; Ida J van der Klei; Marten Veenhuis; Karina von der Malsburg; Bettina Warscheid; Lena-Sophie Wenz; Nils Wiedemann; Ralf M Zerbes; Thomas Becker; Martin van der Laan
Role of mitochondrial inner membrane organizing system in protein biogenesis of the mitochondrial outer membrane.

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All Publications

2013: Nils Wiedemann; Sebastian B Stiller; Nikolaus Pfanner
Activation and degradation of mitofusins: two pathways regulate mitochondrial fusion by reversible ubiquitylation.
Molecular cell 2013;49(3):423-5.
2012: Lena Böttinger; Günther Daum; Susanne E Horvath; Carola Hunte; Thomas Kleinschroth; Nikolaus Pfanner; Thomas Becker
Phosphatidylethanolamine and cardiolipin differentially affect the stability of mitochondrial respiratory chain supercomplexes.
Journal of molecular biology 2012;423(5):677-86.
2012: Maria Bohnert; Agnieszka Chacinska; Günther Daum; Susanne E Horvath; Judith M Müller; Silke Oeljeklaus; Inge Perschil; Nikolaus Pfanner; David A Stroud; Ida J van der Klei; Marten Veenhuis; Karina von der Malsburg; Bettina Warscheid; Lena-Sophie Wenz; Nils Wiedemann; Ralf M Zerbes; Thomas Becker; Martin van der Laan
Role of mitochondrial inner membrane organizing system in protein biogenesis of the mitochondrial outer membrane.
Molecular biology of the cell 2012;23(20):3948-56.
2012: Ralf M Zerbes; Marten Veenhuis; Karina von der Malsburg; Bettina Warscheid; Nils Wiedemann; Thomas Becker; Maria Bohnert; Anita Kram; Silke Oeljeklaus; Nikolaus Pfanner; David A Stroud; Ida J van der Klei; Martin van der Laan
Role of MINOS in mitochondrial membrane architecture: cristae morphology and outer membrane interactions differentially depend on mitofilin domains.
Journal of molecular biology 2012;422(2):183-91.
2012: Michael Gebert; Bernard Guiard; Ilka Haferkamp; Anna K Heißwolf; Carola Hunte; Raffaele Ieva; Thomas Kleinschroth; Carola S Mehnert; Helmut E Meyer; Silke Oeljeklaus; Nikolaus Pfanner; Sandra G Schrempp; Karina von der Malsburg; Bettina Warscheid; Sebastian Wiese; Maria Bohnert; Martin van der Laan
Mgr2 promotes coupling of the mitochondrial presequence translocase to partner complexes.
The Journal of cell biology 2012;197(5):595-604.
2012: Sanjana Rao; Oliver Schmidt; Birgit Schönfisch; bernard guiard; Angelika B Harbauer; Nikolaus Pfanner; Chris Meisinger
Biogenesis of the preprotein translocase of the outer mitochondrial membrane: protein kinase A phosphorylates the precursor of Tom40 and impairs its import.
Molecular biology of the cell 2012;23(9):1618-27.
2012: Martin van der Laan; Nils Wiedemann; Maria Bohnert; Nikolaus Pfanner
Role of MINOS in mitochondrial membrane architecture and biogenesis.
Trends in cell biology 2012;22(4):185-92.
2012: Thomas Becker; Lena Böttinger; Nikolaus Pfanner
Mitochondrial protein import: from transport pathways to an integrated network.
Trends in biochemical sciences 2012;37(3):85-91.
2011: Karina von der Malsburg; Bettina Warscheid; Sebastian Wiese; Ralf M Zerbes; Marten Veenhuis; Thomas Becker; Maria Bohnert; Agnieszka Chacinska; Dana P Hutu; Paulina Kwiatkowska; Adrianna Loniewska-Lwowska; Jean-Claude Martinou; Chris Meisinger; Helmut E Meyer; Dusanka Milenkovic; Judith M Müller; Silke Oeljeklaus; Nikolaus Pfanner; Sanjana Rao; Peter Rehling; Sabine Rospert; Agnes Schulze-Specking; Ida J van der Klei; Martin van der Laan
Dual role of mitofilin in mitochondrial membrane organization and protein biogenesis.
Developmental cell 2011;21(4):694-707.
2011: David A Stroud; Christophe Wirth; Thomas Becker; bernard guiard; Carola Hunte; Chris Meisinger; Nikolaus Pfanner; Sylvia Pfannschmidt; Jian Qiu; Diana Stojanovski; Nils Wiedemann
Biogenesis of mitochondrial β-barrel proteins: the POTRA domain is involved in precursor release from the SAM complex.
Molecular biology of the cell 2011;22(16):2823-33.
2011: Thomas Becker; Agnieszka Chacinska; Luise Goroncy; bernard guiard; Vivien Krüger; Waltraut Lehmann; Trevor Lithgow; Chris Meisinger; Judith M Müller; Richard Wagner; Lena-Sophie Wenz; Nicole Zufall; Nikolaus Pfanner
The mitochondrial import protein Mim1 promotes biogenesis of multispanning outer membrane proteins.
The Journal of cell biology 2011;194(3):387-95.
2011: F-Nora Vögtle; Josef Kellermann; Friedrich Lottspeich; Nikolaus Pfanner; Claudia Prinz; Chris Meisinger
Mitochondrial protein turnover: role of the precursor intermediate peptidase Oct1 in protein stabilization.
Molecular biology of the cell 2011;22(13):2135-43.
2011: Natalia Gebert; Michael T Ryan; Nikolaus Pfanner; Nils Wiedemann; Diana Stojanovski
Mitochondrial protein import machineries and lipids: a functional connection.
Biochimica et biophysica acta 2011;1808(3):1002-11.
2011: Oliver Schmidt; Angelika B Harbauer; Sanjana Rao; Beate Eyrich; René P Zahedi; Diana Stojanovski; Birgit Schönfisch; bernard guiard; Albert Sickmann; Nikolaus Pfanner; Chris Meisinger
Regulation of mitochondrial protein import by cytosolic kinases.
Cell 2011;144(2):227-39.
2011: Thomas Becker; Lena-Sophie Wenz; Nicolas Thornton; David Stroud; Chris Meisinger; Nils Wiedemann; Nikolaus Pfanner
Biogenesis of mitochondria: dual role of Tom7 in modulating assembly of the preprotein translocase of the outer membrane.
Journal of molecular biology 2011;405(1):113-24.
2010: Thomas Becker; bernard guiard; Nicolas Thornton; Nicole Zufall; David A Stroud; Nils Wiedemann; Nikolaus Pfanner
Assembly of the mitochondrial protein import channel: role of Tom5 in two-stage interaction of Tom40 with the SAM complex.
Molecular biology of the cell 2010;21(18):3106-13.
2010: Oliver Schmidt; Nikolaus Pfanner; Chris Meisinger
Mitochondrial protein import: from proteomics to functional mechanisms.
Nature reviews. Molecular cell biology 2010;11(9):655-67.
2010: Michael Bohnert; Peter Rehling; bernard guiard; Johannes M Herrmann; Nikolaus Pfanner; Martin van der Laan
Cooperation of stop-transfer and conservative sorting mechanisms in mitochondrial protein transport.
Current biology : CB 2010;20(13):1227-32.
2010: David A Stroud; Chris Meisinger; Nikolaus Pfanner; Nils Wiedemann
Biochemistry. Assembling the outer membrane.
Science (New York, N.Y.) 2010;328(5980):831-2.
2010: Nicolas Thornton; David A Stroud; Dusanka Milenkovic; bernard guiard; Nikolaus Pfanner; Thomas Becker
Two modular forms of the mitochondrial sorting and assembly machinery are involved in biogenesis of alpha-helical outer membrane proteins.
Journal of molecular biology 2010;396(3):540-9.
2010: F-Nora Vögtle; Oliver Schmidt; Agnieszka Chacinska; Nikolaus Pfanner; Chris Meisinger
Native techniques for analysis of mitochondrial protein import.
Methods in molecular biology (Clifton, N.J.) 2010;619():425-36.
2010: Agnieszka Chacinska; Martin van der Laan; Carola S Mehnert; bernard guiard; David U Mick; Dana P Hutu; Kaye N Truscott; Nils Wiedemann; Chris Meisinger; Nikolaus Pfanner; Peter Rehling
Distinct forms of mitochondrial TOM-TIM supercomplexes define signal-dependent states of preprotein sorting.
Molecular and cellular biology 2010;30(1):307-18.
2009: Natalia Gebert; Amit S Joshi; Stephan Kutik; Thomas Becker; Matthew McKenzie; Xueli Guan; Ved P Mooga; David A Stroud; Gnanada Kulkarni; Markus R Wenk; Peter Rehling; Chris Meisinger; Michael T Ryan; Nils Wiedemann; Miriam L. Greenberg; Nikolaus Pfanner
Mitochondrial cardiolipin involved in outer-membrane protein biogenesis: implications for Barth syndrome.
Current biology : CB 2009;19(24):2133-9.
2009: F-Nora Vögtle; Stefanie Wortelkamp; René P Zahedi; Dorothea Becker; Claudia Leidhold; Kris Gevaert; Josef Kellermann; Wolfgang Voos; Albert Sickmann; Nikolaus Pfanner; Chris Meisinger
Global analysis of the mitochondrial N-proteome identifies a processing peptidase critical for protein stability.
Cell 2009;139(2):428-39.
2009: Karina Wagner; Peter Rehling; Luiza K Sanjuán Szklarz; Rebecca D Taylor; Nikolaus Pfanner; Martin van der Laan
Mitochondrial F1Fo-ATP synthase: the small subunits e and g associate with monomeric complexes to trigger dimerization.
Journal of molecular biology 2009;392(4):855-61.
2009: Agnieszka Chacinska; Carla M Koehler; Dusanka Milenkovic; Trevor Lithgow; Nikolaus Pfanner
Importing mitochondrial proteins: machineries and mechanisms.
Cell 2009;138(4):628-44.
2009: Thomas Becker; Michael Gebert; Nikolaus Pfanner; Martin van der Laan
Biogenesis of mitochondrial membrane proteins.
Current opinion in cell biology 2009;21(4):484-93.
2009: Nils Wiedemann; Chris Meisinger; Nikolaus Pfanner
Cell biology. Connecting organelles.
Science (New York, N.Y.) 2009;325(5939):403-4.
2009: Stephan Kutik; David A Stroud; Nils Wiedemann; Nikolaus Pfanner
Evolution of mitochondrial protein biogenesis.
Biochimica et biophysica acta 2009;1790(6):409-15.
2008: Stephan Kutik; Michael Rissler; Xueli Guan; bernard guiard; Guanghou Shui; Natalia Gebert; Philip N Heacock; Peter Rehling; William Dowhan; Markus R Wenk; Nikolaus Pfanner; Nils Wiedemann
The translocator maintenance protein Tam41 is required for mitochondrial cardiolipin biosynthesis.
The Journal of cell biology 2008;183(7):1213-21.
2008: Agnieszka Chacinska; bernard guiard; Judith M Müller; Agnes Schulze-Specking; Kipros Gabriel; Stephan Kutik; Nikolaus Pfanner
Mitochondrial biogenesis, switching the sorting pathway of the intermembrane space receptor Mia40.
The Journal of biological chemistry 2008;283(44):29723-9.
2008: Diana Stojanovski; Dusanka Milenkovic; Judith M Müller; Kipros Gabriel; Agnes Schulze-Specking; Michael J Baker; Michael T Ryan; bernard guiard; Nikolaus Pfanner; Agnieszka Chacinska
Mitochondrial protein import: precursor oxidation in a ternary complex with disulfide carrier and sulfhydryl oxidase.
The Journal of cell biology 2008;183(2):195-202.
2008: Chris Meisinger; Albert Sickmann; Nikolaus Pfanner
The mitochondrial proteome: from inventory to function.
Cell 2008;134(1):22-4.
2008: Karina Wagner; Natalia Gebert; bernard guiard; Katrin Brandner; Kaye N Truscott; Nils Wiedemann; Nikolaus Pfanner; Peter Rehling
The assembly pathway of the mitochondrial carrier translocase involves four preprotein translocases.
Molecular and cellular biology 2008;28(13):4251-60.
2008: Natalia Gebert; Agnieszka Chacinska; Karina Wagner; bernard guiard; Carla M Koehler; Peter Rehling; Nikolaus Pfanner; Nils Wiedemann
Assembly of the three small Tim proteins precedes docking to the mitochondrial carrier translocase.
EMBO reports 2008;9(6):548-54.
2008: Dana P Hutu; bernard guiard; Agnieszka Chacinska; Dorothea Becker; Nikolaus Pfanner; Peter Rehling; Martin van der Laan
Mitochondrial protein import motor: differential role of Tim44 in the recruitment of Pam17 and J-complex to the presequence translocase.
Molecular biology of the cell 2008;19(6):2642-9.
2008: Diana Stojanovski; Judith M Müller; Dusanka Milenkovic; bernard guiard; Nikolaus Pfanner; Agnieszka Chacinska
The MIA system for protein import into the mitochondrial intermembrane space.
Biochimica et biophysica acta 2008;1783(4):610-7.
2008: Stephan Kutik; Diana Stojanovski; Lars Becker; Thomas Becker; Michael Meinecke; Vivien Krüger; Claudia Prinz; Chris Meisinger; bernard guiard; Richard Wagner; Nikolaus Pfanner; Nils Wiedemann
Dissecting membrane insertion of mitochondrial beta-barrel proteins.
Cell 2008;132(6):1011-24.
2008: Thomas Becker; Sylvia Pfannschmidt; bernard guiard; Diana Stojanovski; Dusanka Milenkovic; Stephan Kutik; Nikolaus Pfanner; Chris Meisinger; Nils Wiedemann
Biogenesis of the mitochondrial TOM complex: Mim1 promotes insertion and assembly of signal-anchored receptors.
The Journal of biological chemistry 2008;283(1):120-7.
2008: Natalia Bolender; Albert Sickmann; Richard Wagner; Chris Meisinger; Nikolaus Pfanner
Multiple pathways for sorting mitochondrial precursor proteins.
EMBO reports 2008;9(1):42-9.
2008: Judith M Müller; Dusanka Milenkovic; bernard guiard; Nikolaus Pfanner; Agnieszka Chacinska
Precursor oxidation by Mia40 and Erv1 promotes vectorial transport of proteins into the mitochondrial intermembrane space.
Molecular biology of the cell 2008;19(1):226-36.
2007: Nils Wiedemann; Martin van der Laan; Dana P Hutu; Peter Rehling; Nikolaus Pfanner
Sorting switch of mitochondrial presequence translocase involves coupling of motor module to respiratory chain.
The Journal of cell biology 2007;179(6):1115-22.
2007: Diana Stojanovski; bernard guiard; Vera Kozjak-Pavlovic; Nikolaus Pfanner; Chris Meisinger
Alternative function for the mitochondrial SAM complex in biogenesis of alpha-helical TOM proteins.
The Journal of cell biology 2007;179(5):881-93.
2007: Stephan Kutik; bernard guiard; Helmut E Meyer; Nils Wiedemann; Nikolaus Pfanner
Cooperation of translocase complexes in mitochondrial protein import.
The Journal of cell biology 2007;179(4):585-91.
2007: Joerg Reinders; Karina Wagner; René P Zahedi; Diana Stojanovski; Beate Eyrich; Martin van der Laan; Peter Rehling; Albert Sickmann; Nikolaus Pfanner; Chris Meisinger
Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase.
Molecular & cellular proteomics : MCP 2007;6(11):1896-906.
2007: Nikolaus Pfanner
Nikolaus Pfanner.
Current biology : CB 2007;17(19):R820-2.
2007: Martin van der Laan; Michael Meinecke; Jan Dudek; Dana P Hutu; Maria Lind; Inge Perschil; bernard guiard; Richard Wagner; Nikolaus Pfanner; Peter Rehling
Motor-free mitochondrial presequence translocase drives membrane integration of preproteins.
Nature cell biology 2007;9(10):1152-9.
2007: Dusanka Milenkovic; Judith Müller; Diana Stojanovski; Nikolaus Pfanner; Agnieszka Chacinska
Diverse mechanisms and machineries for import of mitochondrial proteins.
Biological chemistry 2007;388(9):891-7.
2007: Dusanka Milenkovic; Kipros Gabriel; bernard guiard; Agnes Schulze-Specking; Nikolaus Pfanner; Agnieszka Chacinska
Biogenesis of the essential Tim9-Tim10 chaperone complex of mitochondria: site-specific recognition of cysteine residues by the intermembrane space receptor Mia40.
The Journal of biological chemistry 2007;282(31):22472-80.
2007: Maria Bohnert; Nikolaus Pfanner; Martin van der Laan
A dynamic machinery for import of mitochondrial precursor proteins.
FEBS letters 2007;581(15):2802-10.
2007: Chris Meisinger; Sylvia Pfannschmidt; Michael Rissler; Dusanka Milenkovic; Thomas Becker; Diana Stojanovski; Matthew J Youngman; Robert E Jensen; Agnieszka Chacinska; bernard guiard; Nikolaus Pfanner; Nils Wiedemann
The morphology proteins Mdm12/Mmm1 function in the major beta-barrel assembly pathway of mitochondria.
The EMBO journal 2007;26(9):2229-39.
2007: Luiza K Sanjuán Szklarz; Vera Kozjak-Pavlovic; Friederike-Nora Vögtle; Agnieszka Chacinska; Dusanka Milenkovic; Sandra Vogel; Mark Dürr; Benedikt Westermann; bernard guiard; Jean-Claude Martinou; Christoph Borner; Nikolaus Pfanner; Chris Meisinger
Preprotein transport machineries of yeast mitochondrial outer membrane are not required for Bax-induced release of intermembrane space proteins.
Journal of molecular biology 2007;368(1):44-54.
2007: Kipros Gabriel; Dusanka Milenkovic; Agnieszka Chacinska; Judith Müller; bernard guiard; Nikolaus Pfanner; Chris Meisinger
Novel mitochondrial intermembrane space proteins as substrates of the MIA import pathway.
Journal of molecular biology 2007;365(3):612-20.
2007: Kipros Gabriel; Nikolaus Pfanner
The mitochondrial machinery for import of precursor proteins.
Methods in molecular biology (Clifton, N.J.) 2007;390():99-117.
2007: Diana Stojanovski; Nikolaus Pfanner; Nils Wiedemann
Import of proteins into mitochondria.
Methods in cell biology 2007;80():783-806.
2006: Reinhard Albrecht; Peter Rehling; Agnieszka Chacinska; Jan Brix; Sergio A Cadamuro; Rudolf Volkmer; bernard guiard; Nikolaus Pfanner; Kornelius Zeth
The Tim21 binding domain connects the preprotein translocases of both mitochondrial membranes.
EMBO reports 2006;7(12):1233-8.
2006: Martin van der Laan; Nils Wiedemann; David U Mick; bernard guiard; Peter Rehling; Nikolaus Pfanner
A role for Tim21 in membrane-potential-dependent preprotein sorting in mitochondria.
Current biology : CB 2006;16(22):2271-6.
2006: Chris Meisinger; Nils Wiedemann; Michael Rissler; Andreas Strub; Dusanka Milenkovic; Birgit Schönfisch; Hanne Müller; Vera Kozjak; Nikolaus Pfanner
Mitochondrial protein sorting: differentiation of beta-barrel assembly by Tom7-mediated segregation of Mdm10.
The Journal of biological chemistry 2006;281(32):22819-26.
2006: Joerg Reinders; René P Zahedi; Nikolaus Pfanner; Chris Meisinger; Albert Sickmann
Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics.
Journal of proteome research 2006;5(7):1543-54.
2006: Michael Meinecke; Richard Wagner; Peter Kovermann; bernard guiard; David U Mick; Dana P Hutu; Wolfgang Voos; Kaye N Truscott; Agnieszka Chacinska; Nikolaus Pfanner; Peter Rehling
Tim50 maintains the permeability barrier of the mitochondrial inner membrane.
Science (New York, N.Y.) 2006;312(5779):1523-6.
2006: Diana Stojanovski; Michael Rissler; Nikolaus Pfanner; Chris Meisinger
Mitochondrial morphology and protein import--a tight connection?
Biochimica et biophysica acta 2006;1763(5-6):414-21.
2006: René P Zahedi; Albert Sickmann; Andreas M Boehm; Christiane Winkler; Nicole Zufall; Birgit Schönfisch; bernard guiard; Nikolaus Pfanner; Chris Meisinger
Proteomic analysis of the yeast mitochondrial outer membrane reveals accumulation of a subclass of preproteins.
Molecular biology of the cell 2006;17(3):1436-50.
2006: Nils Wiedemann; Nikolaus Pfanner; Agnieszka Chacinska
Chaperoning through the mitochondrial intermembrane space.
Molecular cell 2006;21(2):145-8.
2006: Nils Wiedemann; Eugen Urzica; bernard guiard; Hanne Müller; Christiane Lohaus; Helmut E Meyer; Michael T Ryan; Chris Meisinger; Ulrich Mühlenhoff; Roland Lill; Nikolaus Pfanner
Essential role of Isd11 in mitochondrial iron-sulfur cluster synthesis on Isu scaffold proteins.
The EMBO journal 2006;25(1):184-95.
2006: Nils Wiedemann; Nikolaus Pfanner; Peter Rehling
Import of precursor proteins into isolated yeast mitochondria.
Methods in molecular biology (Clifton, N.J.) 2006;313():373-83.
2006: Chris Meisinger; Nikolaus Pfanner; Kaye N Truscott
Isolation of yeast mitochondria.
Methods in molecular biology (Clifton, N.J.) 2006;313():33-9.
2005: Lars Becker; Michael Bannwarth; Chris Meisinger; Kerstin Hill; Kirstin Model; Thomas Krimmer; Rita Casadio; Kaye N Truscott; Georg E Schulz; Nikolaus Pfanner; Richard Wagner
Preprotein translocase of the outer mitochondrial membrane: reconstituted Tom40 forms a characteristic TOM pore.
Journal of molecular biology 2005;353(5):1011-20.
2005: Michael Rissler; Nils Wiedemann; Sylvia Pfannschmidt; Kipros Gabriel; bernard guiard; Nikolaus Pfanner; Agnieszka Chacinska
The essential mitochondrial protein Erv1 cooperates with Mia40 in biogenesis of intermembrane space proteins.
Journal of molecular biology 2005;353(3):485-92.
2005: Martin van der Laan; Agnieszka Chacinska; Maria Lind; Inge Perschil; Albert Sickmann; Helmut E Meyer; bernard guiard; Chris Meisinger; Nikolaus Pfanner; Peter Rehling
Pam17 is required for architecture and translocation activity of the mitochondrial protein import motor.
Molecular and cellular biology 2005;25(17):7449-58.
2005: Luiza K Sanjuán Szklarz; bernard guiard; Michael Rissler; Nils Wiedemann; Vera Kozjak; Martin van der Laan; Christiane Lohaus; Katrin Marcus; Helmut E Meyer; Agnieszka Chacinska; Nikolaus Pfanner; Chris Meisinger
Inactivation of the mitochondrial heat shock protein zim17 leads to aggregation of matrix hsp70s followed by pleiotropic effects on morphology and protein biogenesis.
Journal of molecular biology 2005;351(1):206-18.
2005: Agnieszka Chacinska; Maria Lind; Ann E Frazier; Jan Dudek; Chris Meisinger; Andreas Geissler; Albert Sickmann; Helmut E Meyer; Kaye N Truscott; bernard guiard; Nikolaus Pfanner; Peter Rehling
Mitochondrial presequence translocase: switching between TOM tethering and motor recruitment involves Tim21 and Tim17.
Cell 2005;120(6):817-29.
2004: Nikolaus Pfanner; Nils Wiedemann; Chris Meisinger; Trevor Lithgow
Assembling the mitochondrial outer membrane.
Nature structural & molecular biology 2004;11(11):1044-8.
2004: Agnieszka Chacinska; Sylvia Pfannschmidt; Nils Wiedemann; Vera Kozjak; Luiza K Sanjuán Szklarz; Agnes Schulze-Specking; Kaye N Truscott; bernard guiard; Chris Meisinger; Nikolaus Pfanner
Essential role of Mia40 in import and assembly of mitochondrial intermembrane space proteins.
The EMBO journal 2004;23(19):3735-46.
2004: Nikolaus Pfanner; Nils Wiedemann; Chris Meisinger
Cell biology. Double membrane fusion.
Science (New York, N.Y.) 2004;305(5691):1723-4.
2004: Yanfeng Li; Jan Dudek; bernard guiard; Nikolaus Pfanner; Peter Rehling; Wolfgang Voos
The presequence translocase-associated protein import motor of mitochondria. Pam16 functions in an antagonistic manner to Pam18.
The Journal of biological chemistry 2004;279(36):38047-54.
2004: Rebecca D Taylor; Nikolaus Pfanner
The protein import and assembly machinery of the mitochondrial outer membrane.
Biochimica et biophysica acta 2004;1658(1-2):37-43.
2004: Chris Meisinger; Michael Rissler; Agnieszka Chacinska; Luiza K Sanjuán Szklarz; Dusanka Milenkovic; Vera Kozjak; Birgit Schönfisch; Christiane Lohaus; Helmut E Meyer; Michael P Yaffe; bernard guiard; Nils Wiedemann; Nikolaus Pfanner
The mitochondrial morphology protein Mdm10 functions in assembly of the preprotein translocase of the outer membrane.
Developmental cell 2004;7(1):61-71.
2004: Peter Rehling; Katrin Brandner; Nikolaus Pfanner
Mitochondrial import and the twin-pore translocase.
Nature reviews. Molecular cell biology 2004;5(7):519-30.
2004: Dusanka Milenkovic; Vera Kozjak; Nils Wiedemann; Christiane Lohaus; Helmut E Meyer; bernard guiard; Nikolaus Pfanner; Chris Meisinger
Sam35 of the mitochondrial protein sorting and assembly machinery is a peripheral outer membrane protein essential for cell viability.
The Journal of biological chemistry 2004;279(21):22781-5.
2004: Nils Wiedemann; Kaye N Truscott; Sylvia Pfannschmidt; bernard guiard; Chris Meisinger; Nikolaus Pfanner
Biogenesis of the protein import channel Tom40 of the mitochondrial outer membrane: intermembrane space components are involved in an early stage of the assembly pathway.
The Journal of biological chemistry 2004;279(18):18188-94.
2004: Nils Wiedemann; Ann E Frazier; Nikolaus Pfanner
The protein import machinery of mitochondria.
The Journal of biological chemistry 2004;279(15):14473-6.
2004: Ann E Frazier; Jan Dudek; bernard guiard; Wolfgang Voos; Yanfeng Li; Maria Lind; Chris Meisinger; Andreas Geissler; Albert Sickmann; Helmut E Meyer; Virginia Bilanchone; Michael G Cumsky; Kaye N Truscott; Nikolaus Pfanner; Peter Rehling
Pam16 has an essential role in the mitochondrial protein import motor.
Nature structural & molecular biology 2004;11(3):226-33.
2003: Vera Kozjak; Nils Wiedemann; Dusanka Milenkovic; Christiane Lohaus; Helmut E Meyer; bernard guiard; Chris Meisinger; Nikolaus Pfanner
An essential role of Sam50 in the protein sorting and assembly machinery of the mitochondrial outer membrane.
The Journal of biological chemistry 2003;278(49):48520-3.
2003: Kaye N Truscott; Wolfgang Voos; Ann E Frazier; Maria Lind; Yanfeng Li; Andreas Geissler; Jan Dudek; Hanne Müller; Albert Sickmann; Helmut E Meyer; Chris Meisinger; bernard guiard; Peter Rehling; Nikolaus Pfanner
A J-protein is an essential subunit of the presequence translocase-associated protein import motor of mitochondria.
The Journal of cell biology 2003;163(4):707-13.
2003: Albert Sickmann; Joerg Reinders; Yvonne Wagner; Cornelia Joppich; René P Zahedi; Helmut E Meyer; Birgit Schönfisch; Inge Perschil; Agnieszka Chacinska; bernard guiard; Peter Rehling; Nikolaus Pfanner; Chris Meisinger
The proteome of Saccharomyces cerevisiae mitochondria.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(23):13207-12.
2003: Ann E Frazier; Agnieszka Chacinska; Kaye N Truscott; bernard guiard; Nikolaus Pfanner; Peter Rehling
Mitochondria use different mechanisms for transport of multispanning membrane proteins through the intermembrane space.
Molecular and cellular biology 2003;23(21):7818-28.
2003: Agnieszka Chacinska; Peter Rehling; bernard guiard; Ann E Frazier; Agnes Schulze-Specking; Nikolaus Pfanner; Wolfgang Voos; Chris Meisinger
Mitochondrial translocation contact sites: separation of dynamic and stabilizing elements in formation of a TOM-TIM-preprotein supercomplex.
The EMBO journal 2003;22(20):5370-81.
2003: Nils Wiedemann; Vera Kozjak; Agnieszka Chacinska; Birgit Schönfisch; Sabine Rospert; Michael T Ryan; Nikolaus Pfanner; Chris Meisinger
Machinery for protein sorting and assembly in the mitochondrial outer membrane.
Nature 2003;424(6948):565-71.
2003: Kaye N Truscott; Katrin Brandner; Nikolaus Pfanner
Mechanisms of protein import into mitochondria.
Current biology : CB 2003;13(8):R326-37.
2003: Tincuta Stan; Jan Brix; Jens Schneider-Mergener; Nikolaus Pfanner; Walter Neupert; Doron Rapaport
Mitochondrial protein import: recognition of internal import signals of BCS1 by the TOM complex.
Molecular and cellular biology 2003;23(7):2239-50.
2003: Nils Wiedemann; Vera Kozjak; Thorsten Prinz; Michael T Ryan; Chris Meisinger; Nikolaus Pfanner; Kaye N Truscott
Biogenesis of yeast mitochondrial cytochrome c: a unique relationship to the TOM machinery.
Journal of molecular biology 2003;327(2):465-74.
2003: Peter Rehling; Kirstin Model; Katrin Brandner; Peter Kovermann; Albert Sickmann; Helmut E Meyer; Werner Kühlbrandt; Richard Wagner; Kaye N Truscott; Nikolaus Pfanner
Protein insertion into the mitochondrial inner membrane by a twin-pore translocase.
Science (New York, N.Y.) 2003;299(5613):1747-51.
2003: Peter Rehling; Nikolaus Pfanner; Christof Meisinger
Insertion of hydrophobic membrane proteins into the inner mitochondrial membrane--a guided tour.
Journal of molecular biology 2003;326(3):639-57.
2002: Andreas Geissler; Agnieszka Chacinska; Kaye N Truscott; Nils Wiedemann; Katrin Brandner; Albert Sickmann; Helmut E Meyer; Chris Meisinger; Nikolaus Pfanner; Peter Rehling
The mitochondrial presequence translocase: an essential role of Tim50 in directing preproteins to the import channel.
Cell 2002;111(4):507-18.
2002: Kaye N Truscott; Nils Wiedemann; Peter Rehling; Hanne Müller; Chris Meisinger; Nikolaus Pfanner; bernard guiard
Mitochondrial import of the ADP/ATP carrier: the essential TIM complex of the intermembrane space is required for precursor release from the TOM complex.
Molecular and cellular biology 2002;22(22):7780-9.
2002: Nikolaus Pfanner; Agnieszka Chacinska
The mitochondrial import machinery: preprotein-conducting channels with binding sites for presequences.
Biochimica et biophysica acta 2002;1592(1):15-24.
2002: Nikolaus Pfanner; Nils Wiedemann
Mitochondrial protein import: two membranes, three translocases.
Current opinion in cell biology 2002;14(4):400-11.
2002: Agnieszka Chacinska; Nikolaus Pfanner; Chris Meisinger
How mitochondria import hydrophilic and hydrophobic proteins.
Trends in cell biology 2002;12(7):299-303.
2002: Nikolaus Pfanner; Kaye N Truscott
Powering mitochondrial protein import.
Nature structural biology 2002;9(4):234-6.
2002: Kirstin Model; Thorsten Prinz; Teresa Ruiz; Michael Radermacher; Thomas Krimmer; Werner Kühlbrandt; Nikolaus Pfanner; Chris Meisinger
Protein translocase of the outer mitochondrial membrane: role of import receptors in the structural organization of the TOM complex.
Journal of molecular biology 2002;316(3):657-66.
2002: Peter Kovermann; Kaye N Truscott; bernard guiard; Peter Rehling; Naresh B Sepuri; Hanne Müller; Robert E Jensen; Richard Wagner; Nikolaus Pfanner
Tim22, the essential core of the mitochondrial protein insertion complex, forms a voltage-activated and signal-gated channel.
Molecular cell 2002;9(2):363-73.
2001: Kaye N Truscott; Peter Kovermann; Andreas Geissler; A Merlin; M Meijer; Arnold J M Driessen; Joachim Rassow; Nikolaus Pfanner; Richard Wagner
A presequence- and voltage-sensitive channel of the mitochondrial preprotein translocase formed by Tim23.
Nature structural biology 2001;8(12):1074-82.
2001: Andreas Geissler; Joachim Rassow; Nikolaus Pfanner; Wolfgang Voos
Mitochondrial import driving forces: enhanced trapping by matrix Hsp70 stimulates translocation and reduces the membrane potential dependence of loosely folded preproteins.
Molecular and cellular biology 2001;21(20):7097-104.
2001: Thomas Krimmer; Andreas Geissler; Nikolaus Pfanner; Joachim Rassow
Sorting of preproteins into mitochondria.
Chembiochem : a European journal of chemical biology 2001;2(7-8):505-12.
2001: Nikolaus Pfanner; A Geissler
Versatility of the mitochondrial protein import machinery.
Nature reviews. Molecular cell biology 2001;2(5):339-49.
2001: Kirstin Model; Chris Meisinger; Thorsten Prinz; Nils Wiedemann; Kaye N Truscott; Nikolaus Pfanner; Michael T Ryan
Multistep assembly of the protein import channel of the mitochondrial outer membrane.
Nature structural biology 2001;8(4):361-70.
2001: Chris Meisinger; Michael T Ryan; K Hill; Kirstin Model; Joo Hyun Lim; Albert Sickmann; Hanne Müller; Helmut E Meyer; Richard Wagner; Nikolaus Pfanner
Protein import channel of the outer mitochondrial membrane: a highly stable Tom40-Tom22 core structure differentially interacts with preproteins, small tom proteins, and import receptors.
Molecular and cellular biology 2001;21(7):2337-48.
2001: Nils Wiedemann; Nikolaus Pfanner; Michael T Ryan
The three modules of ADP/ATP carrier cooperate in receptor recruitment and translocation into mitochondria.
The EMBO journal 2001;20(5):951-60.
2001: Joo Hyun Lim; Falk Martin; bernard guiard; Nikolaus Pfanner; Wolfgang Voos
The mitochondrial Hsp70-dependent import system actively unfolds preproteins and shortens the lag phase of translocation.
The EMBO journal 2001;20(5):941-50.
2001: Thomas Krimmer; Doron Rapaport; Michael T Ryan; Chris Meisinger; C K Kassenbrock; Elizabeth Blachly-Dyson; Michael Forte; M G Douglas; W Neupert; Frank E Nargang; Nikolaus Pfanner
Biogenesis of porin of the outer mitochondrial membrane involves an import pathway via receptors and the general import pore of the TOM complex.
The Journal of cell biology 2001;152(2):289-300.
2001: Peter Rehling; Nils Wiedemann; Nikolaus Pfanner; Kaye N Truscott
The mitochondrial import machinery for preproteins.
Critical reviews in biochemistry and molecular biology 2001;36(3):291-336.
2001: Kaye N Truscott; Nikolaus Pfanner; Wolfgang Voos
Transport of proteins into mitochondria.
Reviews of physiology, biochemistry and pharmacology 2001;143():81-136.
2001: M T Ryan; Wolfgang Voos; Nikolaus Pfanner
Assaying protein import into mitochondria.
Methods in cell biology 2001;65():189-215.
2000: Chris Meisinger; T Sommer; Nikolaus Pfanner
Purification of Saccharomcyes cerevisiae mitochondria devoid of microsomal and cytosolic contaminations.
Analytical biochemistry 2000;287(2):339-42.
2000: Jan Brix; GA Ziegler; K Dietmeier; Jens Schneider-Mergener; Georg E Schulz; Nikolaus Pfanner
The mitochondrial import receptor Tom70: identification of a 25 kDa core domain with a specific binding site for preproteins.
Journal of molecular biology 2000;303(4):479-88.
2000: Andreas Geissler; Thomas Krimmer; U Bömer; bernard guiard; Joachim Rassow; Nikolaus Pfanner
Membrane potential-driven protein import into mitochondria. The sorting sequence of cytochrome b(2) modulates the deltapsi-dependence of translocation of the matrix-targeting sequence.
Molecular biology of the cell 2000;11(11):3977-91.
2000: Andreas Strub; Joo Hyun Lim; Nikolaus Pfanner; Wolfgang Voos
The mitochondrial protein import motor.
Biological chemistry 2000;381(9-10):943-9.
2000: Thomas Krimmer; Joachim Rassow; W H Kunau; Wolfgang Voos; Nikolaus Pfanner
Mitochondrial protein import motor: the ATPase domain of matrix Hsp70 is crucial for binding to Tim44, while the peptide binding domain and the carboxy-terminal segment play a stimulatory role.
Molecular and cellular biology 2000;20(16):5879-87.
2000: Nikolaus Pfanner
Protein sorting: recognizing mitochondrial presequences.
Current biology : CB 2000;10(11):R412-5.
2000: O von Ahsen; Joo Hyun Lim; P Caspers; Falk Martin; Hans-Joachim Schönfeld; Joachim Rassow; Nikolaus Pfanner
Cyclophilin-promoted folding of mouse dihydrofolate reductase does not include the slow conversion of the late-folding intermediate to the active enzyme.
Journal of molecular biology 2000;297(3):809-18.
1999: Chris Meisinger; Jan Brix; Kirstin Model; Nikolaus Pfanner; Michael T Ryan
The preprotein translocase of the outer mitochondrial membrane: receptors and a general import pore.
Cellular and molecular life sciences : CMLS 1999;56(9-10):817-24.
1999: Wolfgang Voos; H Martin; Thomas Krimmer; Nikolaus Pfanner
Mechanisms of protein translocation into mitochondria.
Biochimica et biophysica acta 1999;1422(3):235-54.
1999: Nikolaus Pfanner
Who chaperones nascent chains in bacteria?
Current biology : CB 1999;9(19):R720-4.
1999: Kaye N Truscott; Nikolaus Pfanner
Import of carrier proteins into mitochondria.
Biological chemistry 1999;380(10):1151-6.
1999: S van Wilpe; Michael T Ryan; K Hill; AC Maarse; Chris Meisinger; Jan Brix; PJ Dekker; M Moczko; Richard Wagner; M Meijer; bernard guiard; A Hönlinger; Nikolaus Pfanner
Tom22 is a multifunctional organizer of the mitochondrial preprotein translocase.
Nature 1999;401(6752):485-9.
1999: Michael T Ryan; Hanne Müller; Nikolaus Pfanner
Functional staging of ADP/ATP carrier translocation across the outer mitochondrial membrane.
The Journal of biological chemistry 1999;274(29):20619-27.
1999: M Kurz; H Martin; Joachim Rassow; Nikolaus Pfanner; Michael T Ryan
Biogenesis of Tim proteins of the mitochondrial carrier import pathway: differential targeting mechanisms and crossing over with the main import pathway.
Molecular biology of the cell 1999;10(7):2461-74.
1999: Jan Brix; Stefan Rüdiger; Bernd Bukau; Jens Schneider-Mergener; Nikolaus Pfanner
Distribution of binding sequences for the mitochondrial import receptors Tom20, Tom22, and Tom70 in a presequence-carrying preprotein and a non-cleavable preprotein.
The Journal of biological chemistry 1999;274(23):16522-30.
1999: A Merlin; Wolfgang Voos; AC Maarse; M Meijer; Nikolaus Pfanner; Joachim Rassow
The J-related segment of tim44 is essential for cell viability: a mutant Tim44 remains in the mitochondrial import site, but inefficiently recruits mtHsp70 and impairs protein translocation.
The Journal of cell biology 1999;145(5):961-72.
1999: C Voisine; Elizabeth A Craig; Nicole Zufall; O von Ahsen; Nikolaus Pfanner; Wolfgang Voos
The protein import motor of mitochondria: unfolding and trapping of preproteins are distinct and separable functions of matrix Hsp70.
Cell 1999;97(5):565-74.
1998: H Martin; C Eckerskorn; F Gärtner; Joachim Rassow; F Lottspeich; Nikolaus Pfanner
The yeast mitochondrial intermembrane space: purification and analysis of two distinct fractions.
Analytical biochemistry 1998;265(1):123-8.
1998: PJ Dekker; Michael T Ryan; Jan Brix; Hanne Müller; A Hönlinger; Nikolaus Pfanner
Preprotein translocase of the outer mitochondrial membrane: molecular dissection and assembly of the general import pore complex.
Molecular and cellular biology 1998;18(11):6515-24.
1998: K Hill; Kirstin Model; Michael T Ryan; K Dietmeier; F Martin; Richard Wagner; Nikolaus Pfanner
Tom40 forms the hydrophilic channel of the mitochondrial import pore for preproteins [see comment].
Nature 1998;395(6701):516-21.
1998: U Bömer; AC Maarse; Falk Martin; Andreas Geissler; A Merlin; Birgit Schönfisch; M Meijer; Nikolaus Pfanner; Joachim Rassow
Separation of structural and dynamic functions of the mitochondrial translocase: Tim44 is crucial for the inner membrane import sites in translocation of tightly folded domains, but not of loosely folded preproteins.
The EMBO journal 1998;17(15):4226-37.
1998: A Palmisano; Vincenzo Zara; A Hönlinger; Angelo Vozza; PJ Dekker; Nikolaus Pfanner; Ferdinando Palmieri
Targeting and assembly of the oxoglutarate carrier: general principles for biogenesis of carrier proteins of the mitochondrial inner membrane.
The Biochemical journal 1998;333 ( Pt 1)():151-8.
1998: M Kübrich; Joachim Rassow; Wolfgang Voos; Nikolaus Pfanner; A Hönlinger
The import route of ADP/ATP carrier into mitochondria separates from the general import pathway of cleavable preproteins at the trans side of the outer membrane.
The Journal of biological chemistry 1998;273(26):16374-81.
1998: Nikolaus Pfanner
Mitochondrial import: crossing the aqueous intermembrane space.
Current biology : CB 1998;8(8):R262-5.
1998: Michael T Ryan; Nikolaus Pfanner
The preprotein translocase of the mitochondrial outer membrane.
Biological chemistry 1998;379(3):289-94.
1997: U Bömer; M Meijer; bernard guiard; K Dietmeier; Nikolaus Pfanner; Joachim Rassow
The sorting route of cytochrome b2 branches from the general mitochondrial import pathway at the preprotein translocase of the inner membrane.
The Journal of biological chemistry 1997;272(48):30439-46.
1997: M Moczko; U Bömer; M Kübrich; Nicole Zufall; A Hönlinger; Nikolaus Pfanner
The intermembrane space domain of mitochondrial Tom22 functions as a trans binding site for preproteins with N-terminal targeting sequences.
Molecular and cellular biology 1997;17(11):6574-84.
1997: A Merlin; O von Ahsen; Elizabeth A Craig; K Dietmeier; Nikolaus Pfanner
A mutant form of mitochondrial GrpE suppresses the sorting defect caused by an alteration in the presequence of cytochrome b2.
Journal of molecular biology 1997;273(1):1-6.
1997: PJ Dekker; Falk Martin; AC Maarse; U Bömer; Hanne Müller; bernard guiard; M Meijer; Joachim Rassow; Nikolaus Pfanner
The Tim core complex defines the number of mitochondrial translocation contact sites and can hold arrested preproteins in the absence of matrix Hsp70-Tim44.
The EMBO journal 1997;16(17):5408-19.
1997: Jan Brix; K Dietmeier; Nikolaus Pfanner
Differential recognition of preproteins by the purified cytosolic domains of the mitochondrial import receptors Tom20, Tom22, and Tom70.
The Journal of biological chemistry 1997;272(33):20730-5.
1997: O von Ahsen; Maximilian Tropschug; Nikolaus Pfanner; Joachim Rassow
The chaperonin cycle cannot substitute for prolyl isomerase activity, but GroEL alone promotes productive folding of a cyclophilin-sensitive substrate to a cyclophilin-resistant form.
The EMBO journal 1997;16(15):4568-78.
1997: PJ Dekker; Nikolaus Pfanner
Role of mitochondrial GrpE and phosphate in the ATPase cycle of matrix Hsp70.
Journal of molecular biology 1997;270(3):321-7.
1997: K Dietmeier; A Hönlinger; U Bömer; PJ Dekker; C Eckerskorn; F Lottspeich; M Kübrich; Nikolaus Pfanner
Tom5 functionally links mitochondrial preprotein receptors to the general import pore.
Nature 1997;388(6638):195-200.
1997: U Bömer; M Meijer; AC Maarse; A Hönlinger; PJ Dekker; Nikolaus Pfanner; Joachim Rassow
Multiple interactions of components mediating preprotein translocation across the inner mitochondrial membrane.
The EMBO journal 1997;16(9):2205-16.
1997: Nikolaus Pfanner; M Meijer
The Tom and Tim machine.
Current biology : CB 1997;7(2):R100-3.
1997: Nikolaus Pfanner; E A Craig; A Hönlinger
Mitochondrial preprotein translocase.
Annual review of cell and developmental biology 1997;13():25-51.
1996: Vincenzo Zara; K Dietmeier; A Palmisano; Angelo Vozza; Joachim Rassow; Ferdinando Palmieri; Nikolaus Pfanner
Yeast mitochondria lacking the phosphate carrier/p32 are blocked in phosphate transport but can import preproteins after regeneration of a membrane potential.
Molecular and cellular biology 1996;16(11):6524-31.
1996: U Bömer; Joachim Rassow; N Zufall; Nikolaus Pfanner; M Meijer; AC Maarse
The preprotein translocase of the inner mitochondrial membrane: evolutionary conservation of targeting and assembly of Tim17.
Journal of molecular biology 1996;262(4):389-95.
1996: P J Dekker; H Müller; Joachim Rassow; Nikolaus Pfanner
Characterization of the preprotein translocase of the outer mitochondrial membrane by blue native electrophoresis.
Biological chemistry 1996;377(7-8):535-8.
1996: Wolfgang Voos; O von Ahsen; Hanne Müller; bernard guiard; Joachim Rassow; Nikolaus Pfanner
Differential requirement for the mitochondrial Hsp70-Tim44 complex in unfolding and translocation of preproteins.
The EMBO journal 1996;15(11):2668-77.
1996: A Hönlinger; U Bömer; A Alconada; C Eckerskorn; F Lottspeich; K Dietmeier; Nikolaus Pfanner
Tom7 modulates the dynamics of the mitochondrial outer membrane translocase and plays a pathway-related role in protein import.
The EMBO journal 1996;15(9):2125-37.
1996: U Bömer; Nikolaus Pfanner; K Dietmeier
Identification of a third yeast mitochondrial Tom protein with tetratrico peptide repeats.
FEBS letters 1996;382(1-2):153-8.
1996: Nikolaus Pfanner; M G Douglas; T Endo; N J Hoogenraad; Robert E Jensen; M Meijer; W Neupert; G Schatz; U K Schmitz; G C Shore
Uniform nomenclature for the protein transport machinery of the mitochondrial membranes.
Trends in biochemical sciences 1996;21(2):51-2.
1996: Joachim Rassow; Nikolaus Pfanner
Protein biogenesis: chaperones for nascent polypeptides.
Current biology : CB 1996;6(2):115-8.
1995: O von Ahsen; Wolfgang Voos; H Henninger; Nikolaus Pfanner
The mitochondrial protein import machinery. Role of ATP in dissociation of the Hsp70.Mim44 complex.
The Journal of biological chemistry 1995;270(50):29848-53.
1995: M Moczko; B Schönfisch; Wolfgang Voos; Nikolaus Pfanner; Joachim Rassow
The mitochondrial ClpB homolog Hsp78 cooperates with matrix Hsp70 in maintenance of mitochondrial function.
Journal of molecular biology 1995;254(4):538-43.
1995: F Gärtner; U Bömer; bernard guiard; Nikolaus Pfanner
The sorting signal of cytochrome b2 promotes early divergence from the general mitochondrial import pathway and restricts the unfoldase activity of matrix Hsp70.
The EMBO journal 1995;14(23):6043-57.
1995: Shikha Laloraya; PJ Dekker; Wolfgang Voos; Elizabeth A Craig; Nikolaus Pfanner
Mitochondrial GrpE modulates the function of matrix Hsp70 in translocation and maturation of preproteins.
Molecular and cellular biology 1995;15(12):7098-105.
1995: N Seki; M Moczko; T Nagase; N Zufall; B Ehmann; K Dietmeier; Eberhard Schäfer; N Nomura; Nikolaus Pfanner
A human homolog of the mitochondrial protein import receptor Mom19 can assemble with the yeast mitochondrial receptor complex.
FEBS letters 1995;375(3):307-10.
1995: A Alconada; M Kübrich; M Moczko; A Hönlinger; Nikolaus Pfanner
The mitochondrial receptor complex: the small subunit Mom8b/Isp6 supports association of receptors with the general insertion pore and transfer of preproteins.
Molecular and cellular biology 1995;15(11):6196-205.
1995: A Hönlinger; P Keil; R J Nelson; Elizabeth A Craig; Nikolaus Pfanner
Posttranslational mitochondrial protein import in a homologous yeast in vitro system.
Biological chemistry Hoppe-Seyler 1995;376(8):515-9.
1995: Joachim Rassow; Wolfgang Voos; Nikolaus Pfanner
Partner proteins determine multiple functions of Hsp70.
Trends in cell biology 1995;5(5):207-12.
1995: Joachim Rassow; K Mohrs; S Koidl; I B Barthelmess; Nikolaus Pfanner; Maximilian Tropschug
Cyclophilin 20 is involved in mitochondrial protein folding in cooperation with molecular chaperones Hsp70 and Hsp60.
Molecular and cellular biology 1995;15(5):2654-62.
1995: M Kübrich; K Dietmeier; Nikolaus Pfanner
Genetic and biochemical dissection of the mitochondrial protein-import machinery.
Current genetics 1995;27(5):393-403.
1995: F Gärtner; Wolfgang Voos; A Querol; B R Miller; Elizabeth A Craig; M G Cumsky; Nikolaus Pfanner
Mitochondrial import of subunit Va of cytochrome c oxidase characterized with yeast mutants.
The Journal of biological chemistry 1995;270(8):3788-95.
1995: Nikolaus Pfanner; M Meijer
Protein sorting. Pulling in the proteins.
Current biology : CB 1995;5(2):132-5.
1995: A Alconada; F Gärtner; A Hönlinger; M Kübrich; Nikolaus Pfanner
Mitochondrial receptor complex from Neurospora crassa and Saccharomyces cerevisiae.
Methods in enzymology 1995;260():263-86.
1994: Joachim Rassow; AC Maarse; E Krainer; M Kübrich; Hanne Müller; M Meijer; Elizabeth A Craig; Nikolaus Pfanner
Mitochondrial protein import: biochemical and genetic evidence for interaction of matrix hsp70 and the inner membrane protein MIM44.
The Journal of cell biology 1994;127(6 Pt 1):1547-56.
1994: Wolfgang Voos; B D Gambill; Shikha Laloraya; D Ang; Elizabeth A Craig; Nikolaus Pfanner
Mitochondrial GrpE is present in a complex with hsp70 and preproteins in transit across membranes.
Molecular and cellular biology 1994;14(10):6627-34.
1994: Nikolaus Pfanner; Elizabeth A Craig; M Meijer
The protein import machinery of the mitochondrial inner membrane.
Trends in biochemical sciences 1994;19(9):368-72.
1994: M Kübrich; P Keil; Joachim Rassow; PJ Dekker; J Blom; M Meijer; Nikolaus Pfanner
The polytopic mitochondrial inner membrane proteins MIM17 and MIM23 operate at the same preprotein import site.
FEBS letters 1994;349(2):222-8.
1994: AC Maarse; J Blom; P Keil; Nikolaus Pfanner; M Meijer
Identification of the essential yeast protein MIM17, an integral mitochondrial inner membrane protein involved in protein import.
FEBS letters 1994;349(2):215-21.
1994: J Schlossmann; K Dietmeier; Nikolaus Pfanner; Walter Neupert
Specific recognition of mitochondrial preproteins by the cytosolic domain of the import receptor MOM72.
The Journal of biological chemistry 1994;269(16):11893-901.
1994: M Moczko; B Ehmann; F Gärtner; A Hönlinger; Eberhard Schäfer; Nikolaus Pfanner
Deletion of the receptor MOM19 strongly impairs import of cleavable preproteins into Saccharomyces cerevisiae mitochondria.
The Journal of biological chemistry 1994;269(12):9045-51.
1993: K Dietmeier; Vincenzo Zara; A Palmisano; Ferdinando Palmieri; Wolfgang Voos; J Schlossmann; M Moczko; Gyula Kispal; Nikolaus Pfanner
Targeting and translocation of the phosphate carrier/p32 to the inner membrane of yeast mitochondria.
The Journal of biological chemistry 1993;268(34):25958-64.
1993: J Blom; M Kübrich; Joachim Rassow; Wolfgang Voos; PJ Dekker; AC Maarse; M Meijer; Nikolaus Pfanner
The essential yeast protein MIM44 (encoded by MPI1) is involved in an early step of preprotein translocation across the mitochondrial inner membrane.
Molecular and cellular biology 1993;13(12):7364-71.
1993: Wolfgang Voos; B D Gambill; bernard guiard; Nikolaus Pfanner; Elizabeth A Craig
Presequence and mature part of preproteins strongly influence the dependence of mitochondrial protein import on heat shock protein 70 in the matrix.
The Journal of cell biology 1993;123(1):119-26.
1993: B D Gambill; Wolfgang Voos; P J Kang; B Miao; T Langer; Elizabeth A Craig; Nikolaus Pfanner
A dual role for mitochondrial heat shock protein 70 in membrane translocation of preproteins.
The Journal of cell biology 1993;123(1):109-17.
1993: P Keil; A Weinzierl; M Kiebler; K Dietmeier; T Söllner; Nikolaus Pfanner
Biogenesis of the mitochondrial receptor complex. Two receptors are required for binding of MOM38 to the outer membrane surface.
The Journal of biological chemistry 1993;268(26):19177-80.
1993: PJ Dekker; P Keil; Joachim Rassow; AC Maarse; Nikolaus Pfanner; M Meijer
Identification of MIM23, a putative component of the protein import machinery of the mitochondrial inner membrane.
FEBS letters 1993;330(1):66-70.
1993: M Kiebler; K Becker; Nikolaus Pfanner; Walter Neupert
Mitochondrial protein import: specific recognition and membrane translocation of preproteins.
The Journal of membrane biology 1993;135(3):191-207.
1993: M Kiebler; P Keil; H Schneider; Ida Van der klei; Nikolaus Pfanner; Walter Neupert
The mitochondrial receptor complex: a central role of MOM22 in mediating preprotein transfer from receptors to the general insertion pore.
Cell 1993;74(3):483-92.
1993: M Moczko; F Gärtner; Nikolaus Pfanner
The protein import receptor MOM19 of yeast mitochondria.
FEBS letters 1993;326(1-3):251-4.
1993: P Keil; Nikolaus Pfanner
Insertion of MOM22 into the mitochondrial outer membrane strictly depends on surface receptors.
FEBS letters 1993;321(2-3):197-200.
1993: Walter Neupert; Nikolaus Pfanner
Roles of molecular chaperones in protein targeting to mitochondria.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1993;339(1289):355-61; discussion 361-2.
1992: M Moczko; K Dietmeier; T Söllner; B Segui; H F Steger; Walter Neupert; Nikolaus Pfanner
Identification of the mitochondrial receptor complex in Saccharomyces cerevisiae.
FEBS letters 1992;310(3):265-8.
1992: Vincenzo Zara; Ferdinando Palmieri; K Mahlke; Nikolaus Pfanner
The cleavable presequence is not essential for import and assembly of the phosphate carrier of mammalian mitochondria but enhances the specificity and efficiency of import.
The Journal of biological chemistry 1992;267(17):12077-81.
1992: Nikolaus Pfanner; Joachim Rassow; Ida Van der klei; Walter Neupert
A dynamic model of the mitochondrial protein import machinery.
Cell 1992;68(6):999-1002.
1992: K Becker; bernard guiard; Joachim Rassow; T Söllner; Nikolaus Pfanner
Targeting of a chemically pure preprotein to mitochondria does not require the addition of a cytosolic signal recognition factor.
The Journal of biological chemistry 1992;267(8):5637-43.
1992: P Keil; J Schlossmann; Nikolaus Pfanner
Targeting and translocation of mitochondrial precursor proteins.
Antonie van Leeuwenhoek 1992;61(2):135-42.
1992: T Söllner; Joachim Rassow; M Wiedmann; J Schlossmann; P Keil; Walter Neupert; Nikolaus Pfanner
Mapping of the protein import machinery in the mitochondrial outer membrane by crosslinking of translocation intermediates.
Nature 1992;355(6355):84-7.
1991: H Schneider; T Söllner; K Dietmeier; C Eckerskorn; F Lottspeich; B Trülzsch; Walter Neupert; Nikolaus Pfanner
Targeting of the master receptor MOM19 to mitochondria.
Science (New York, N.Y.) 1991;254(5038):1659-62.
1991: U Wienhues; K Becker; M Schleyer; bernard guiard; Maximilian Tropschug; A L Horwich; Nikolaus Pfanner; Walter Neupert
Protein folding causes an arrest of preprotein translocation into mitochondria in vivo.
The Journal of cell biology 1991;115(6):1601-9.
1991: Joachim Rassow; Nikolaus Pfanner
Mitochondrial preproteins en route from the outer membrane to the inner membrane are exposed to the intermembrane space.
FEBS letters 1991;293(1-2):85-8.
1991: J Martin; K Mahlke; Nikolaus Pfanner
Role of an energized inner membrane in mitochondrial protein import. Delta psi drives the movement of presequences.
The Journal of biological chemistry 1991;266(27):18051-7.
1991: Vincenzo Zara; Joachim Rassow; E Wachter; Maximilian Tropschug; Ferdinando Palmieri; Walter Neupert; Nikolaus Pfanner
Biogenesis of the mitochondrial phosphate carrier.
European journal of biochemistry / FEBS 1991;198(2):405-10.
1991: Nikolaus Pfanner; T Söllner; Walter Neupert
Mitochondrial import receptors for precursor proteins.
Trends in biochemical sciences 1991;16(2):63-7.
1991: T Söllner; Joachim Rassow; Nikolaus Pfanner
Analysis of mitochondrial protein import using translocation intermediates and specific antibodies.
Methods in cell biology 1991;34():345-58.
1990: J Ostermann; Wolfgang Voos; P J Kang; Elizabeth A Craig; Walter Neupert; Nikolaus Pfanner
Precursor proteins in transit through mitochondrial contact sites interact with hsp70 in the matrix.
FEBS letters 1990;277(1-2):281-4.
1990: M Kiebler; R Pfaller; T Söllner; G Griffiths; H Horstmann; Nikolaus Pfanner; Walter Neupert
Identification of a mitochondrial receptor complex required for recognition and membrane insertion of precursor proteins.
Nature 1990;348(6302):610-6.
1990: H F Steger; T Söllner; M Kiebler; K Dietmeier; R Pfaller; K S Trülzsch; Maximilian Tropschug; Walter Neupert; Nikolaus Pfanner
Import of ADP/ATP carrier into mitochondria: two receptors act in parallel.
The Journal of cell biology 1990;111(6 Pt 1):2353-63.
1990: Joachim Rassow; F U Hartl; bernard guiard; Nikolaus Pfanner; Walter Neupert
Polypeptides traverse the mitochondrial envelope in an extended state.
FEBS letters 1990;275(1-2):190-4.
1990: P J Kang; J Ostermann; J Shilling; Walter Neupert; Elizabeth A Craig; Nikolaus Pfanner
Requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins.
Nature 1990;348(6297):137-43.
1990: Walter Neupert; F U Hartl; Elizabeth A Craig; Nikolaus Pfanner
How do polypeptides cross the mitochondrial membranes?
Cell 1990;63(3):447-50.
1990: Nikolaus Pfanner; J Ostermann; Joachim Rassow; F U Hartl; Walter Neupert
Stress proteins and mitochondrial protein import.
Antonie van Leeuwenhoek 1990;58(3):191-3.
1990: Nikolaus Pfanner; Joachim Rassow; bernard guiard; T Söllner; F U Hartl; Walter Neupert
Energy requirements for unfolding and membrane translocation of precursor proteins during import into mitochondria.
The Journal of biological chemistry 1990;265(27):16324-9.
1990: K Mahlke; Nikolaus Pfanner; J Martin; A L Horwich; F U Hartl; Walter Neupert
Sorting pathways of mitochondrial inner membrane proteins.
European journal of biochemistry / FEBS 1990;192(2):551-5.
1990: Nikolaus Pfanner; Walter Neupert
A mitochondrial machinery for membrane translocation of precursor proteins.
Biochemical Society transactions 1990;18(4):513-5.
1990: Nikolaus Pfanner; Joachim Rassow; U Wienhues; C Hergersberg; T Söllner; K Becker; Walter Neupert
Contact sites between inner and outer membranes: structure and role in protein translocation into the mitochondria.
Biochimica et biophysica acta 1990;1018(2-3):239-42.
1990: T Söllner; R Pfaller; G Griffiths; Nikolaus Pfanner; Walter Neupert
A mitochondrial import receptor for the ADP/ATP carrier.
Cell 1990;62(1):107-15.
1989: T Söllner; G Griffiths; R Pfaller; Nikolaus Pfanner; Walter Neupert
MOM19, an import receptor for mitochondrial precursor proteins.
Cell 1989;59(6):1061-70.
1989: F U Hartl; Nikolaus Pfanner; D W Nicholson; Walter Neupert
Mitochondrial protein import.
Biochimica et biophysica acta 1989;988(1):1-45.
1989: R Pfaller; Nikolaus Pfanner; Walter Neupert
Mitochondrial protein import. Bypass of proteinaceous surface receptors can occur with low specificity and efficiency.
The Journal of biological chemistry 1989;264(1):34-9.
1988: R Pfaller; H F Steger; Joachim Rassow; Nikolaus Pfanner; Walter Neupert
Import pathways of precursor proteins into mitochondria: multiple receptor sites are followed by a common membrane insertion site.
The Journal of cell biology 1988;107(6 Pt 2):2483-90.
1988: Maximilian Tropschug; D W Nicholson; F U Hartl; H Köhler; Nikolaus Pfanner; E Wachter; Walter Neupert
Cyclosporin A-binding protein (cyclophilin) of Neurospora crassa. One gene codes for both the cytosolic and mitochondrial forms.
The Journal of biological chemistry 1988;263(28):14433-40.
1988: Nikolaus Pfanner; F U Hartl; Walter Neupert
Import of proteins into mitochondria: a multi-step process.
European journal of biochemistry / FEBS 1988;175(2):205-12.
1988: Nikolaus Pfanner; R Pfaller; R Kleene; M Ito; Maximilian Tropschug; Walter Neupert
Role of ATP in mitochondrial protein import. Conformational alteration of a precursor protein can substitute for ATP requirement.
The Journal of biological chemistry 1988;263(9):4049-51.
1988: T Söllner; Nikolaus Pfanner; Walter Neupert
Mitochondrial protein import: differential recognition of various transport intermediates by antibodies.
FEBS letters 1988;229(1):25-9.
1987: Nikolaus Pfanner; F U Hartl; bernard guiard; Walter Neupert
Mitochondrial precursor proteins are imported through a hydrophilic membrane environment.
European journal of biochemistry / FEBS 1987;169(2):289-93.
1987: Nikolaus Pfanner; P Hoeben; Maximilian Tropschug; Walter Neupert
The carboxyl-terminal two-thirds of the ADP/ATP carrier polypeptide contains sufficient information to direct translocation into mitochondria.
The Journal of biological chemistry 1987;262(31):14851-4.
1987: Nikolaus Pfanner; H K Müller; M A Harmey; Walter Neupert
Mitochondrial protein import: involvement of the mature part of a cleavable precursor protein in the binding to receptor sites.
The EMBO journal 1987;6(11):3449-54.
1987: R Kleene; Nikolaus Pfanner; R Pfaller; T A Link; W Sebald; Walter Neupert; Maximilian Tropschug
Mitochondrial porin of Neurospora crassa: cDNA cloning, in vitro expression and import into mitochondria.
The EMBO journal 1987;6(9):2627-33.