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Gerd Pfeifer

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Physiology

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TOP 3
Alejandro Lomniczi; Gerd P Pfeifer; Oline K Ronnekleiv; Hollis Wright; Martha Bosch; Juan Manuel Castellano; Gabi Kaidar; J Gabriel Knoll; Alberto Loche; Sergio R Ojeda
Epigenetic control of female puberty.
Maria A Hahn; Yong Jiang; Seung-Gi Jin; Jonathan Jui; Arthur X Li; Gerd P Pfeifer; Runxiang Qiu; Jun Wang; Xiwei Wu; Heying Zhang; Qiang Lu
Dynamics of 5-hydroxymethylcytosine and chromatin marks in Mammalian neurogenesis.
Gerd P Pfeifer; Swati Kadam; Seung-Gi Jin
5-hydroxymethylcytosine and its potential roles in development and cancer.

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2013: Alejandro Lomniczi; Gerd P Pfeifer; Oline K Ronnekleiv; Hollis Wright; Martha Bosch; Juan Manuel Castellano; Gabi Kaidar; J Gabriel Knoll; Alberto Loche; Sergio R Ojeda
Epigenetic control of female puberty.
Nature neuroscience 2013;16(3):281-9.
2013: Maria A Hahn; Yong Jiang; Seung-Gi Jin; Jonathan Jui; Arthur X Li; Gerd P Pfeifer; Runxiang Qiu; Jun Wang; Xiwei Wu; Heying Zhang; Qiang Lu
Dynamics of 5-hydroxymethylcytosine and chromatin marks in Mammalian neurogenesis.
Cell reports 2013;3(2):291-300.
2013: Gerd P Pfeifer; Swati Kadam; Seung-Gi Jin
5-hydroxymethylcytosine and its potential roles in development and cancer.
Epigenetics & chromatin 2013;6(1):10.
2012: Piroska E Szabó; Gerd P Pfeifer
H3K9me2 attracts PGC7 in the zygote to prevent Tet3-mediated oxidation of 5-methylcytosine.
Journal of molecular cell biology 2012;4(6):427-9.
2012: Gerd P Pfeifer
Protein phosphatase PP4: role in dephosphorylation of KAP1 and DNA strand break repair.
Cell cycle (Georgetown, Tex.) 2012;11(14):2590-1.
2012: Byung-Wook Kim; Gerd P Pfeifer; R Steven Esworthy; Maria A Hahn; Fong-Fong Chu
Expression of lactoperoxidase in differentiated mouse colon epithelial cells.
Free radical biology & medicine 2012;52(9):1569-76.
2012: Tibor A Rauch; Arthur D Riggs; Zunde Wang; Xiwei Wu; Kemp H Kernstine; Gerd P Pfeifer
DNA methylation biomarkers for lung cancer.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2012;33(2):287-96.
2012: Myriam Lereau; Ghislaine Martel-Planche; André Nogueira da Costa; Sandra Ortiz-Cuaran; Gerd P Pfeifer; Stéphanie Villar; Doriane Gouas; Pierre Hainaut; Olivier Hantz; Agnès Hautefeuille; Pascale Berthillon; Ahmad Besaratinia; Isabelle Chemin
Interactions between hepatitis B virus and aflatoxin B(1): effects on p53 induction in HepaRG cells.
The Journal of general virology 2012;93(Pt 3):640-50.
2012: Christoph Lahtz; Arthur X Li; Steven E Bates; Maria A Hahn; Yong Jiang; Xiwei Wu; Gerd P Pfeifer
Gamma irradiation does not induce detectable changes in DNA methylation directly following exposure of human cells.
PloS one 2012;7(9):e44858.
2012: Ahmad Besaratinia; Gerd P Pfeifer
Measuring the formation and repair of UV damage at the DNA sequence level by ligation-mediated PCR.
Methods in molecular biology (Clifton, N.J.) 2012;920():189-202.
2012: Li Zheng; John Zhong; Mian Zhou; Charles Wang; Jun Wu; Xiwei Wu; Huifang Dai; Julio Garcia-Aguilar; Zhigang Guo; Qin Huang; Xiaojin Li; Changwei Liu; Gerd P Pfeifer; Binghui Shen
Polyploid cells rewire DNA damage response networks to overcome replication stress-induced barriers for tumour progression.
Nature communications 2012;3():815.
2011: Sang-In Kim; Gerd P Pfeifer; David H Phillips; Jae-In Yoon; Volker M Arlt; Kathleen J Cole; Ahmad Besaratinia
Whole body exposure of mice to secondhand smoke induces dose-dependent and persistent promutagenic DNA adducts in the lung.
Mutation research 2011;716(1-2):92-8.
2011: Tian-Peng Gu; Fan Guo; Xinyi He; Khursheed Iqbal; Seung-Gi Jin; Jinsong Li; Wei Liu; Gerd P Pfeifer; Linyu Shi; Yujiang Geno Shi; Piroska E Szabó; Hai-Ping Wu; Zhi-Guo Xie; Gui-Fang Xu; Zixin Deng; Hui Yang; Guo-Liang Xu
The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes.
Nature 2011;477(7366):606-10.
2011: Ahmad Besaratinia; Stephen E Bradforth; Myles Cockburn; Christi Schroeder; Jae-In Yoon; Gerd P Pfeifer
Wavelength dependence of ultraviolet radiation-induced DNA damage as determined by laser irradiation suggests that cyclobutane pyrimidine dimers are the principal DNA lesions produced by terrestrial sunlight.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011;25(9):3079-91.
2011: Eun-Rim Kang; Gerd P Pfeifer; Guillermo E Rivas; Purnima Singh; Khursheed Iqbal; Diana A Tran; Piroska E Szabó
Effects of endocrine disruptors on imprinted gene expression in the mouse embryo.
Epigenetics : official journal of the DNA Methylation Society 2011;6(7):937-50.
2011: Li Zheng; Xueyan Zhong; Mian Zhou; Lei Su; Jun Wu; Xiwei Wu; Huifang Dai; Zhigang Guo; Muralidhar L Hegde; Qin Huang; Kemp H Kernstine; Sankar Mitra; Gerd P Pfeifer; Binghui Shen
Fen1 mutations that specifically disrupt its interaction with PCNA cause aneuploidy-associated cancer.
Cell research 2011;21(7):1052-67.
2011: Seung-Gi Jin; Arthur X Li; Xiwei Wu; Gerd P Pfeifer
Genomic mapping of 5-hydroxymethylcytosine in the human brain.
Nucleic acids research 2011;39(12):5015-24.
2011: Purnima Singh; Xiwei Wu; Dong-Hoon Lee; Arthur X Li; Tibor Rauch; Gerd P Pfeifer; Jeffrey R Mann; Piroska E Szabó
Chromosome-wide analysis of parental allele-specific chromatin and DNA methylation.
Molecular and cellular biology 2011;31(8):1757-70.
2011: Khursheed Iqbal; Seung-Gi Jin; Gerd P Pfeifer; Piroska E Szabó
Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(9):3642-7.
2011: Jin Sun; James Liu; Xueliang Pan; Donald Quimby; nicola zanesi; Teresa Druck; Gerd P Pfeifer; Carlo M Croce; Louise Y Fong; Kay Huebner
Effect of zinc supplementation on N-nitrosomethylbenzylamine-induced forestomach tumor development and progression in tumor suppressor-deficient mouse strains.
Carcinogenesis 2011;32(3):351-8.
2011: Cai Guo; Xiaoying Zhang; Gerd P Pfeifer
The tumor suppressor RASSF1A prevents dephosphorylation of the mammalian STE20-like kinases MST1 and MST2.
The Journal of biological chemistry 2011;286(8):6253-61.
2011: Stella Tommasi; A Besaratinia; Sharon P Wilczynski; Gerd P Pfeifer
Loss of Rassf1a enhances p53-mediated tumor predisposition and accelerates progression to aneuploidy.
Oncogene 2011;30(6):690-700.
2011: Christoph Lahtz; Gerd P Pfeifer
Epigenetic changes of DNA repair genes in cancer.
Journal of molecular cell biology 2011;3(1):51-8.
2011: Ahmad Besaratinia; Gerd P Pfeifer
Uveal melanoma and GNA11 mutations: a new piece added to the puzzle.
Pigment cell & melanoma research 2011;24(1):18-20.
2011: Dong-Hoon Lee; Diana A Tran; Purnima Singh; Nathan Oates; Guillermo E Rivas; Garrett P Larson; Gerd P Pfeifer; Piroska E Szabó
MIRA-SNuPE, a quantitative, multiplex method for measuring allele-specific DNA methylation.
Epigenetics : official journal of the DNA Methylation Society 2011;6(2):212-23.
2011: Masanobu Abe; Seung-Gi Jin; Gerd P Pfeifer; Shirley Y Tsai; Piroska E Szabó
Sex-specific dynamics of global chromatin changes in fetal mouse germ cells.
PloS one 2011;6(8):e23848.
2011: Maria A Hahn; Xiwei Wu; Arthur X Li; Torsten Hahn; Gerd P Pfeifer
Relationship between gene body DNA methylation and intragenic H3K9me3 and H3K36me3 chromatin marks.
PloS one 2011;6(4):e18844.
2011: Gerd P Pfeifer; Pierre Hainaut
Next-generation sequencing: emerging lessons on the origins of human cancer.
Current opinion in oncology 2011;23(1):62-8.
2010: Sang-In Kim; Monica Hollstein; Gerd P Pfeifer; Ahmad Besaratinia
Unveiling the methylation status of CpG dinucleotides in the substituted segment of the human p53 knock-in (Hupki) mouse genome.
Molecular carcinogenesis 2010;49(12):999-1006.
2010: Maria A Hahn; Gerd P Pfeifer
Methods for genome-wide analysis of DNA methylation in intestinal tumors.
Mutation research 2010;693(1-2):77-83.
2010: Dong-Hoon Lee; Purnima Singh; Shirley Y Tsai; Nathan Oates; Alexander Spalla; Claudio Spalla; Lucy Brown; Guillermo Rivas; Garrett Larson; Tibor A Rauch; Gerd P Pfeifer; Piroska E Szabó
CTCF-dependent chromatin bias constitutes transient epigenetic memory of the mother at the H19-Igf2 imprinting control region in prospermatogonia.
PLoS genetics 2010;6(11):e1001224.
2010: Tibor A Rauch; Gerd P Pfeifer
DNA methylation profiling using the methylated-CpG island recovery assay (MIRA).
Methods (San Diego, Calif.) 2010;52(3):213-7.
2010: AnhThu Nguyen; Tibor A Rauch; Gerd P Pfeifer; Valerie W Hu
Global methylation profiling of lymphoblastoid cell lines reveals epigenetic contributions to autism spectrum disorders and a novel autism candidate gene, RORA, whose protein product is reduced in autistic brain.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(8):3036-51.
2010: Ahmad Besaratinia; Gerd P Pfeifer
Applications of the human p53 knock-in (Hupki) mouse model for human carcinogen testing.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(8):2612-9.
2010: Seung-Gi Jin; Swati Kadam; Gerd P Pfeifer
Examination of the specificity of DNA methylation profiling techniques towards 5-methylcytosine and 5-hydroxymethylcytosine.
Nucleic acids research 2010;38(11):e125.
2010: Gerd P Pfeifer; Reinhard Dammann; Stella Tommasi
RASSF proteins.
Current biology : CB 2010;20(8):R344-5.
2010: Se-Young Lee; Gerd P Pfeifer; Chong-Soon Lee
Mutation spectra induced by adozelesin in the supF gene of human XP-A fibroblasts.
Archives of pharmacal research 2010;33(4):633-6.
2010: Xiwei Wu; Tibor Rauch; Xueyan Zhong; Patrick Williams; Farida Latif; Dietmar Krex; Gerd P Pfeifer
CpG island hypermethylation in human astrocytomas.
Cancer research 2010;70(7):2718-27.
2010: Giel Hendriks; Fabienne Calléja; Ahmad Besaratinia; Harry Vrieling; Gerd P Pfeifer; Leon H F Mullenders; Jacob G Jansen; Niels De Wind
Transcription-dependent cytosine deamination is a novel mechanism in ultraviolet light-induced mutagenesis.
Current biology : CB 2010;20(2):170-5.
2010: Jeong-Hyeon Choi; Yajun Li; Juyuan Guo; Lirong Pei; Tibor A Rauch; Robin S Kramer; Simone L Macmil; Graham B Wiley; Lynda B Bennett; Jennifer L Schnabel; Kristen H Taylor; Sun Kim; Dong Xu; Arun Sreekumar; Gerd P Pfeifer; Bruce A Roe; Charles Caldwell; Kapil N Bhalla; Huidong Shi
Genome-wide DNA methylation maps in follicular lymphoma cells determined by methylation-enriched bisulfite sequencing.
PloS one 2010;5(9):.
2010: Satish Kalari; Gerd P Pfeifer
Identification of driver and passenger DNA methylation in cancer by epigenomic analysis.
Advances in genetics 2010;70():277-308.
2010: Gerd P Pfeifer
Environmental exposures and mutational patterns of cancer genomes.
Genome medicine 2010;2(8):54.
2010: Stella Tommasi; Sang-in Kim; Xueyan Zhong; Xiwei Wu; Gerd P Pfeifer; Ahmad Besaratinia
Investigating the epigenetic effects of a prototype smoke-derived carcinogen in human cells.
PloS one 2010;5(5):e10594.
2010: Victoria K Hill; Luke Hesson; Temuujin Dansranjavin; Ashraf Dallol; Ivan Bieche; Sophie Vacher; Stella Tommasi; Timothy Dobbins; Dean Gentle; David Euhus; Cheryl Lewis; Reinhard Dammann; Robyn L Ward; John Minna; Eammon R Maher; Gerd P Pfeifer; Farida Latif
Identification of 5 novel genes methylated in breast and other epithelial cancers.
Molecular cancer 2010;9():51.
2010: Thomas Dunwell; Luke Hesson; Tibor A Rauch; Lihui Wang; Richard E Clark; Ashraf Dallol; Dean Gentle; Daniel Catchpoole; Eamonn R Maher; Gerd P Pfeifer; Farida Latif
A genome-wide screen identifies frequently methylated genes in haematological and epithelial cancers.
Molecular cancer 2010;9():44.
2009: Antje M Richter; Gerd P Pfeifer; Reinhard H Dammann
The RASSF proteins in cancer; from epigenetic silencing to functional characterization.
Biochimica et biophysica acta 2009;1796(2):114-28.
2009: Gerd P Pfeifer; Piroska E Szabo
Sperm histones are organized to carry epigenetic clues into the zygote .
Epigenomics 2009;1(1):23.
2009: Gerd P Pfeifer; Piroska E Szabo
Enhancers in the spotlight.
Epigenomics 2009;1(1):22.
2009: Gerd P Pfeifer; Piroska E Szabo
5-hydroxymethylcytosine, a modified mammalian DNA base with a potential regulatory role.
Epigenomics 2009;1(1):21-2.
2009: Ahmad Besaratinia; Sang-In Kim; Pierre Hainaut; Gerd P Pfeifer
In vitro recapitulating of TP53 mutagenesis in hepatocellular carcinoma associated with dietary aflatoxin B1 exposure.
Gastroenterology 2009;137(3):1127-37, 1137.e1-5.
2009: Delvac Oceandy; Adam Pickard; Sukhpal Prehar; Min Zi; Tamer M A Mohamed; Peter J Stanley; Florence Baudoin-Stanley; Raja Nadif; Stella Tommasi; Gerd P Pfeifer; Angel L Armesilla; Elizabeth J Cartwright; Ludwig Neyses
Tumor suppressor Ras-association domain family 1 isoform A is a novel regulator of cardiac hypertrophy.
Circulation 2009;120(7):607-16.
2009: Haibo Wang; Ailian Zhao; Lin Chen; Xueyan Zhong; Ji Liao; Min Gao; Minghua Cai; Dong-Hyun Lee; Jing Li; Dipanjan Chowdhury; Yun-gui Yang; Gerd P Pfeifer; Yun Yen; Xingzhi Xu
Human RIF1 encodes an anti-apoptotic factor required for DNA repair.
Carcinogenesis 2009;30(8):1314-9.
2009: Gerd P Pfeifer; Tibor Rauch
DNA methylation patterns in lung carcinomas.
Seminars in cancer biology 2009;19(3):181-7.
2009: Gerd P Pfeifer; Ahmad Besaratinia
Mutational spectra of human cancer.
Human genetics 2009;125(5-6):493-506.
2009: Ahmad Besaratinia; Gerd P Pfeifer
DNA-lesion mapping in mammalian cells.
Methods (San Diego, Calif.) 2009;48(1):35-9.
2009: Xiaoying Zhang; Dongyun Liu; Shuang Lv; Haibo Wang; Xueyan Zhong; Bo Liu; Bo Wang; Ji Liao; Jing Li; Gerd P Pfeifer; Xingzhi Xu
CDK5RAP2 is required for spindle checkpoint function.
Cell cycle (Georgetown, Tex.) 2009;8(8):1206-16.
2009: Tibor Rauch; Xiwei Wu; Xueyan Zhong; Arthur D Riggs; Gerd P Pfeifer
A human B cell methylome at 100-base pair resolution.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(3):671-8.
2009: Akio Kuroda; Tibor A Rauch; Ivan Todorov; Hsun Teresa Ku; Ismail H Al-Abdullah; Fouad Kandeel; Yoko Mullen; Gerd P Pfeifer; Kevin Ferreri
Insulin gene expression is regulated by DNA methylation.
PloS one 2009;4(9):e6953.
2009: Stella Tommasi; Deborah L Karm; Xiwei Wu; Yun Yen; Gerd P Pfeifer
Methylation of homeobox genes is a frequent and early epigenetic event in breast cancer.
Breast cancer research : BCR 2009;11(1):R14.
2009: Tibor Rauch; Gerd P Pfeifer
The MIRA method for DNA methylation analysis.
Methods in molecular biology (Clifton, N.J.) 2009;507():65-75.
2008: Seung-Gi Jin; Walter Tsark; Piroska E Szabó; Gerd P Pfeifer
Haploid male germ cell- and oocyte-specific Mbd3l1 and Mbd3l2 genes are dispensable for early development, fertility, and zygotic DNA demethylation in the mouse.
Developmental dynamics : an official publication of the American Association of Anatomists 2008;237(11):3435-43.
2008: Limin Liu; C Guo; Reinhard Dammann; Stella Tommasi; Gerd P Pfeifer
RASSF1A interacts with and activates the mitotic kinase Aurora-A.
Oncogene 2008;27(47):6175-86.
2008: Bo Wang; Ailian Zhao; Lingling Sun; Xueyan Zhong; Jianing Zhong; Haibo Wang; Minhua Cai; Jing Li; Yi Xu; Ji Liao; Jianli Sang; Dipanjan Chowdhury; Gerd P Pfeifer; Yun Yen; Xingzhi Xu
Protein phosphatase PP4 is overexpressed in human breast and lung tumors.
Cell research 2008;18(9):974-7.
2008: Byung-Wook Kim; Byung-Chun Kim; Jin Soon Cha; Gerd P Pfeifer; Chong-Soon Lee
Mutation spectra induced by 1-nitropyrene 4,5-oxide and 1-nitropyrene 9,10-oxide in the supF gene of human XP-A fibroblasts.
BMB reports 2008;41(8):604-8.
2008: Ahmad Besaratinia; Gerd P Pfeifer
Sunlight ultraviolet irradiation and BRAF V600 mutagenesis in human melanoma.
Human mutation 2008;29(8):983-91.
2008: Dipanjan Chowdhury; Xingzhi Xu; Xueyan Zhong; Fariyal Ahmed; Jianing Zhong; Ji Liao; Derek M. Dykxhoorn; David M Weinstock; Gerd P Pfeifer; Judy Lieberman
A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication.
Molecular cell 2008;31(1):33-46.
2008: Ahmad Besaratinia; Gerd P Pfeifer
Second-hand smoke and human lung cancer.
The lancet oncology 2008;9(7):657-66.
2008: Ahmad Besaratinia; Sang-In Kim; Gerd P Pfeifer
Rapid repair of UVA-induced oxidized purines and persistence of UVB-induced dipyrimidine lesions determine the mutagenicity of sunlight in mouse cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(7):2379-92.
2008: Dong-Hyun Lee; Gerd P Pfeifer
Translesion synthesis of 7,8-dihydro-8-oxo-2'-deoxyguanosine by DNA polymerase eta in vivo.
Mutation research 2008;641(1-2):19-26.
2008: Seung-Gi Jin; Cai Guo; Gerd P Pfeifer
GADD45A does not promote DNA demethylation.
PLoS genetics 2008;4(3):e1000013.
2008: Tibor Rauch; Xueyan Zhong; Xiwei Wu; Melody Wang; Kemp H Kernstine; Zunde Wang; Arthur D Riggs; Gerd P Pfeifer
High-resolution mapping of DNA hypermethylation and hypomethylation in lung cancer.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(1):252-7.
2007: Sang-in Kim; Gerd P Pfeifer; Ahmad Besaratinia
Lack of mutagenicity of acrolein-induced DNA adducts in mouse and human cells.
Cancer research 2007;67(24):11640-7.
2007: Claudia Seidel; Undraga Schagdarsurengin; Karen Blümke; Peter Würl; Gerd P Pfeifer; Steffen Hauptmann; Helge Taubert; Reinhard Dammann
Frequent hypermethylation of MST1 and MST2 in soft tissue sarcoma.
Molecular carcinogenesis 2007;46(10):865-71.
2007: Gerd P Pfeifer; Arthur D Riggs; Zunde Wang; Tibor A Rauch
Methylated-CpG island recovery assay-assisted microarrays for cancer diagnosis.
Expert opinion on medical diagnostics 2007;1(1):99-108.
2007: Limin Liu; Katrin Baier; Reinhard Dammann; Gerd P Pfeifer
The tumor suppressor RASSF1A does not interact with Cdc20, an activator of the anaphase-promoting complex.
Cell cycle (Georgetown, Tex.) 2007;6(13):1663-5.
2007: Undraga Schagdarsurengin; Gerd P Pfeifer; Reinhard Dammann
Frequent epigenetic inactivation of cystatin M in breast carcinoma.
Oncogene 2007;26(21):3089-94.
2007: Cai Guo; Stella Tommasi; Limin Liu; Jiing-Kuan Yee; Reinhard Dammann; Gerd P Pfeifer
RASSF1A is part of a complex similar to the Drosophila Hippo/Salvador/Lats tumor-suppressor network.
Current biology : CB 2007;17(8):700-5.
2007: Ahmad Besaratinia; Sang-In Kim; Steven E Bates; Gerd P Pfeifer
Riboflavin activated by ultraviolet A1 irradiation induces oxidative DNA damage-mediated mutations inhibited by vitamin C.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(14):5953-8.
2007: Sang-in Kim; Gerd P Pfeifer; Ahmad Besaratinia
Mutagenicity of ultraviolet A radiation in the lacI transgene in Big Blue mouse embryonic fibroblasts.
Mutation research 2007;617(1-2):71-8.
2007: Tibor Rauch; Zunde Wang; Xinmin Zhang; Xueyan Zhong; Xiwei Wu; Sean K Lau; Kemp H Kernstine; Arthur D Riggs; Gerd P Pfeifer
Homeobox gene methylation in lung cancer studied by genome-wide analysis with a microarray-based methylated CpG island recovery assay.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(13):5527-32.
2007: Ahmad Besaratinia; Gerd P Pfeifer
A review of mechanisms of acrylamide carcinogenicity.
Carcinogenesis 2007;28(3):519-28.
2007: Dong-Hyun Lee; Gerd P Pfeifer
Mutagenesis induced by the nitric oxide donor sodium nitroprusside in mouse cells.
Mutagenesis 2007;22(1):63-7.
2006: Samridhi C Goswami; Jung-Hoon Yoon; Bozena M Abramczyk; Gerd P Pfeifer; Edith H Postel
Molecular and functional interactions between Escherichia coli nucleoside-diphosphate kinase and the uracil-DNA glycosylase Ung.
The Journal of biological chemistry 2006;281(43):32131-9.
2006: Dong-Hyun Lee; R Steven Esworthy; Christy Chu; Gerd P Pfeifer; Fong-Fong Chu
Mutation accumulation in the intestine and colon of mice deficient in two intracellular glutathione peroxidases.
Cancer research 2006;66(20):9845-51.
2006: Tibor Rauch; Hongwei Li; Xiwei Wu; Gerd P Pfeifer
MIRA-assisted microarray analysis, a new technology for the determination of DNA methylation patterns, identifies frequent methylation of homeodomain-containing genes in lung cancer cells.
Cancer research 2006;66(16):7939-47.
2006: Ahmad Besaratinia; Gerd P Pfeifer
Investigating human cancer etiology by DNA lesion footprinting and mutagenicity analysis.
Carcinogenesis 2006;27(8):1526-37.
2006: Jun-Hyuk Choi; Ahmad Besaratinia; Dong-Hyun Lee; Chong-Soon Lee; Gerd P Pfeifer
The role of DNA polymerase iota in UV mutational spectra.
Mutation research 2006;599(1-2):58-65.
2006: Hongwei Li; Tibor Rauch; Zhao-Xia Chen; Piroska E Szabó; Arthur D Riggs; Gerd P Pfeifer
The histone methyltransferase SETDB1 and the DNA methyltransferase DNMT3A interact directly and localize to promoters silenced in cancer cells.
The Journal of biological chemistry 2006;281(28):19489-500.
2006: Jung-Hoon Yoon; Junzhuan Qiu; Sheng Cai; Yuan Chen; Michael Cheetham; Binghui Shen; Gerd P Pfeifer
The retinitis pigmentosa-mutated RP2 protein exhibits exonuclease activity and translocates to the nucleus in response to DNA damage.
Experimental cell research 2006;312(8):1323-34.
2006: Xueyan Zhong; Gerd P Pfeifer; Xingzhi Xu
Microcephalin encodes a centrosomal protein.
Cell cycle (Georgetown, Tex.) 2006;5(4):457-8.
2006: Alon Goren; Giora Simchen; Eitan Fibach; Piroska E Szabo; Keiji Tanimoto; Lyubomira Chakalova; Gerd P Pfeifer; Peter J Fraser; James Douglas Engel; Howard Cedar
Fine tuning of globin gene expression by DNA methylation.
PloS one 2006;1():e46.
2006: Graciela Spivak; Gerd P Pfeifer; Philip C Hanawalt
In vivo assays for transcription-coupled repair.
Methods in enzymology 2006;408():223-46.
2006: Gerd P Pfeifer
Measuring the formation and repair of DNA damage by ligation-mediated PCR.
Methods in molecular biology (Clifton, N.J.) 2006;314():201-14.
2006: Gerd P Pfeifer
Mutagenesis at methylated CpG sequences.
Current topics in microbiology and immunology 2006;301():259-81.
2006: Sheng Cai; Brian H Lee; Cindy Cheng; weidong hu; Jung-Hoon Yoon; Gerd P Pfeifer; Yuan Chen
1H, 13C and 15N resonance assignments of the C-terminal domain of RP2.
Journal of biomolecular NMR 2006;36 Suppl 1():9.
2005: Jung-Hoon Yoon; Purnima Singh; Dong-Hyun Lee; Junzhuan Qiu; Sheng Cai; Timothy R O'Connor; Yuan Chen; Binghui Shen; Gerd P Pfeifer
Characterization of the 3' --> 5' exonuclease activity found in human nucleoside diphosphate kinase 1 (NDK1) and several of its homologues.
Biochemistry 2005;44(48):15774-86.
2005: Dong-Hyun Lee; Seung-Gi Jin; Sheng Cai; Yuan Chen; Gerd P Pfeifer; Timothy R O'Connor
Repair of methylation damage in DNA and RNA by mammalian AlkB homologues.
The Journal of biological chemistry 2005;280(47):39448-59.
2005: Ashraf Dallol; Angelo Agathanggelou; Stella Tommasi; Gerd P Pfeifer; Eamonn R Maher; Farida Latif
Involvement of the RASSF1A tumor suppressor gene in controlling cell migration.
Cancer research 2005;65(17):7653-9.
2005: Xueyan Zhong; Limin Liu; Ailian Zhao; Gerd P Pfeifer; Xingzhi Xu
The abnormal spindle-like, microcephaly-associated (ASPM) gene encodes a centrosomal protein.
Cell cycle (Georgetown, Tex.) 2005;4(9):1227-9.
2005: Tibor Rauch; Gerd P Pfeifer
Methylated-CpG island recovery assay: a new technique for the rapid detection of methylated-CpG islands in cancer.
Laboratory investigation; a journal of technical methods and pathology 2005;85(9):1172-80.
2005: Tibor Rauch; Xueyan Zhong; Gerd P Pfeifer; Xingzhi Xu
53BP1 is a positive regulator of the BRCA1 promoter.
Cell cycle (Georgetown, Tex.) 2005;4(8):1078-83.
2005: Ahmad Besaratinia; Timothy W Synold; Hsiu-Hua Chen; Cheng Chang; Bixin Xi; Arthur D Riggs; Gerd P Pfeifer
DNA lesions induced by UV A1 and B radiation in human cells: comparative analyses in the overall genome and in the p53 tumor suppressor gene.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(29):10058-63.
2005: Daniela Castanotto; Stella Tommasi; Mingjie Li; Haitang Li; Stephanie Yanow; Gerd P Pfeifer; John J Rossi
Short hairpin RNA-directed cytosine (CpG) methylation of the RASSF1A gene promoter in HeLa cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(1):179-83.
2005: Ahmad Besaratinia; Gerd P Pfeifer
Investigating DNA adduct-targeted mutagenicity of tamoxifen: preferential formation of tamoxifen-DNA adducts in the human p53 gene in SV40 immortalized hepatocytes but not endometrial carcinoma cells.
Biochemistry 2005;44(23):8418-27.
2005: Shairaz Baksh; Stella Tommasi; Sarah Fenton; Victor C Yu; L Miguel Martins; Gerd P Pfeifer; Farida Latif; Julian Downward; Benjamin G Neel
The tumor suppressor RASSF1A and MAP-1 link death receptor signaling to Bax conformational change and cell death.
Molecular cell 2005;18(6):637-50.
2005: Gerd P Pfeifer; Reinhard Dammann
Methylation of the tumor suppressor gene RASSF1A in human tumors.
Biochemistry. Biokhimii͡a 2005;70(5):576-83.
2005: Gerd P Pfeifer; Young-Hyun You; Ahmad Besaratinia
Mutations induced by ultraviolet light.
Mutation research 2005;571(1-2):19-31.
2005: Reinhard Dammann; Undraga Schagdarsurengin; Claudia Seidel; Maria Strunnikova; Matthias Rastetter; K Baier; Gerd P Pfeifer
The tumor suppressor RASSF1A in human carcinogenesis: an update.
Histology and histopathology 2005;20(2):645-63.
2005: Seung-Gi Jin; Chun-Ling Jiang; Tibor Rauch; Hongwei Li; Gerd P Pfeifer
MBD3L2 interacts with MBD3 and components of the NuRD complex and can oppose MBD2-MeCP1-mediated methylation silencing.
The Journal of biological chemistry 2005;280(13):12700-9.
2005: Hyun-Jo Kim; Tae-Ho Kim; Sun-Young Lee; Dong-Hoon Lee; Sang-In Kim; Gerd P Pfeifer; Seog K Kim; Chong-Soon Lee
DNA sequence analysis of 1-nitropyrene-4,5-oxide and 1-nitropyrene-9,10-oxide induced mutations in the hprt gene of Chinese hamster ovary cells.
Molecules and cells 2005;19(1):114-23.
2005: Ahmad Besaratinia; Gerd P Pfeifer
DNA adduction and mutagenic properties of acrylamide.
Mutation research 2005;580(1-2):31-40.
2005: Jun-Hyuk Choi; Gerd P Pfeifer
The role of DNA polymerase eta in UV mutational spectra.
DNA repair 2005;4(2):211-20.
2005: Stella Tommasi; Reinhard Dammann; Zhongqiu Zhang; Yian Wang; Limin Liu; Walter M Tsark; Sharon P Wilczynski; Jie Li; Ming You; Gerd P Pfeifer
Tumor susceptibility of Rassf1a knockout mice.
Cancer research 2005;65(1):92-8.
2005: Reinhard Dammann; Undraga Schagdarsurengin; Claudia Seidel; C Trümpler; Cuong Hoang-Vu; Oliver Gimm; Henning Dralle; Gerd P Pfeifer; Michael Brauckhoff
Frequent promoter methylation of tumor-related genes in sporadic and men2-associated pheochromocytomas.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2005;113(1):1-7.
2005: Limin Liu; Jingmei Zhang; Steven Bates; Jian Jian Li; Dana M Peehl; Johng S Rhim; Gerd P Pfeifer
A methylation profile of in vitro immortalized human cell lines.
International journal of oncology 2005;26(1):275-85.
2004: Jun-Hyuk Choi; Gerd P Pfeifer
DNA damage and mutations produced by chloroacetaldehyde in a CpG-methylated target gene.
Mutation research 2004;568(2):245-56.
2004: Ahmad Besaratinia; Steven E Bates; Timothy W Synold; Gerd P Pfeifer
Similar mutagenicity of photoactivated porphyrins and ultraviolet A radiation in mouse embryonic fibroblasts: involvement of oxidative DNA lesions in mutagenesis.
Biochemistry 2004;43(49):15557-66.
2004: Punnajit Lim; Gerald E Wuenschell; Vanessa Holland; Dong-Hyun Lee; Gerd P Pfeifer; Henry Rodriguez; John Termini
Peroxyl radical mediated oxidative DNA base damage: implications for lipid peroxidation induced mutagenesis.
Biochemistry 2004;43(49):15339-48.
2004: Chun-Ling Jiang; Seung-Gi Jin; Gerd P Pfeifer
MBD3L1 is a transcriptional repressor that interacts with methyl-CpG-binding protein 2 (MBD2) and components of the NuRD complex.
The Journal of biological chemistry 2004;279(50):52456-64.
2004: Ahmad Besaratinia; Gerd P Pfeifer
Biological consequences of 8-methoxypsoralen-photoinduced lesions: sequence-specificity of mutations and preponderance of T to C and T to a mutations.
The Journal of investigative dermatology 2004;123(6):1140-6.
2004: Jung-Hoon Yoon; Ahmad Besaratinia; Zhaohui Feng; Moon-shong Tang; Shantu Amin; Andreas Luch; Gerd P Pfeifer
DNA damage, repair, and mutation induction by (+)-Syn and (-)-anti-dibenzo[a,l]pyrene-11,12-diol-13,14-epoxides in mouse cells.
Cancer research 2004;64(20):7321-8.
2004: Shahrooz Rabizadeh; Ramnik Xavier; Kazuhiro Ishiguro; Juliocesar Bernabeortiz; Marco Lopez-Ilasaca; Andrei Khokhlatchev; Pamela Mollahan; Gerd P Pfeifer; Joseph Avruch; Brian Seed
The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death.
The Journal of biological chemistry 2004;279(28):29247-54.
2004: Ahmad Besaratinia; Gerd P Pfeifer
Genotoxicity of acrylamide and glycidamide.
Journal of the National Cancer Institute 2004;96(13):1023-9.
2004: Ahmad Besaratinia; Timothy W Synold; Bixin Xi; Gerd P Pfeifer
G-to-T transversions and small tandem base deletions are the hallmark of mutations induced by ultraviolet a radiation in mammalian cells.
Biochemistry 2004;43(25):8169-77.
2004: Piroska E Szabó; Gerd P Pfeifer; Jeffrey R Mann
Parent-of-origin-specific binding of nuclear hormone receptor complexes in the H19-Igf2 imprinting control region.
Molecular and cellular biology 2004;24(11):4858-68.
2004: Jingmei Zhang; Limin Liu; Gerd P Pfeifer
Methylation of the retinoid response gene TIG1 in prostate cancer correlates with methylation of the retinoic acid receptor beta gene.
Oncogene 2004;23(12):2241-9.
2003: Ahmad Besaratinia; Gerd P Pfeifer
Enhancement of the mutagenicity of benzo(a)pyrene diol epoxide by a nonmutagenic dose of ultraviolet A radiation.
Cancer research 2003;63(24):8708-16.
2003: Limin Liu; Stella Tommasi; Dong-Hyun Lee; Reinhard Dammann; Gerd P Pfeifer
Control of microtubule stability by the RASSF1A tumor suppressor.
Oncogene 2003;22(50):8125-36.
2003: Jung-Hoon Yoon; Shigenori Iwai; Timothy R O'Connor; Gerd P Pfeifer
Human thymine DNA glycosylase (TDG) and methyl-CpG-binding protein 4 (MBD4) excise thymine glycol (Tg) from a Tg:G mispair.
Nucleic acids research 2003;31(18):5399-404.
2003: Ahmad Besaratinia; Gerd P Pfeifer
Weak yet distinct mutagenicity of acrylamide in mammalian cells.
Journal of the National Cancer Institute 2003;95(12):889-96.
2003: Reinhard Dammann; Undraga Schagdarsurengin; Limin Liu; Noreen Otto; Oliver Gimm; Henning Dralle; Bernhard O Boehm; Gerd P Pfeifer; Cuong Hoang-Vu
Frequent RASSF1A promoter hypermethylation and K-ras mutations in pancreatic carcinoma.
Oncogene 2003;22(24):3806-12.
2003: Gerd P Pfeifer; Pierre Hainaut
On the origin of G --> T transversions in lung cancer.
Mutation research 2003;526(1-2):39-43.
2003: Igor Kuzmin; Limin Liu; Reinhard Dammann; Laura Geil; Eric J Stanbridge; Sharon P Wilczynski; Michael I Lerman; Gerd P Pfeifer
Inactivation of RAS association domain family 1A gene in cervical carcinomas and the role of human papillomavirus infection.
Cancer research 2003;63(8):1888-93.
2003: Mia Spugnardi; Stella Tommasi; Reinhard Dammann; Gerd P Pfeifer; Dave S B Hoon
Epigenetic inactivation of RAS association domain family protein 1 (RASSF1A) in malignant cutaneous melanoma.
Cancer research 2003;63(7):1639-43.
2003: Reinhard Dammann; Undraga Schagdarsurengin; Maria Strunnikova; Matthias Rastetter; Claudia Seidel; L Liu; Stella Tommasi; Gerd P Pfeifer
Epigenetic inactivation of the Ras-association domain family 1 (RASSF1A) gene and its function in human carcinogenesis.
Histology and histopathology 2003;18(2):665-77.
2003: Undraga Schagdarsurengin; Ludwig Wilkens; Doris Steinemann; Peer Flemming; Hans H Kreipe; Gerd P Pfeifer; Brigitte Schlegelberger; Reinhard Dammann
Frequent epigenetic inactivation of the RASSF1A gene in hepatocellular carcinoma.
Oncogene 2003;22(12):1866-71.
2003: Dong-Hyun Lee; Gerd P Pfeifer
Deamination of 5-methylcytosines within cyclobutane pyrimidine dimers is an important component of UVB mutagenesis.
The Journal of biological chemistry 2003;278(12):10314-21.
2003: Jung-Hoon Yoon; Chong-Soon Lee; Gerd P Pfeifer
Simulated sunlight and benzo[a]pyrene diol epoxide induced mutagenesis in the human p53 gene evaluated by the yeast functional assay: lack of correspondence to tumor mutation spectra.
Carcinogenesis 2003;24(1):113-9.
2002: Dong-Hyun Lee; Tae-Ho Kim; Sun-Young Lee; Hyun-Jo Kim; Seung-Keun Rhee; ByoungSu Yoon; Gerd P Pfeifer; Chong-Soon Lee
Mutations induced by 1,3-butadiene metabolites, butadiene diolepoxide, and 1,2,3,4-diepoxybutane at the Hprt locus in CHO-K1 cells.
Molecules and cells 2002;14(3):411-9.
2002: Chun Ling Jiang; Seung-Gi Jin; Dong Hyun Lee; Zi Jian Lan; Xueping Xu; Timothy R O'Connor; Piroska E Szabó; Jeffrey R Mann; Austin J Cooney; Gerd P Pfeifer
MBD3L1 and MBD3L2, two new proteins homologous to the methyl-CpG-binding proteins MBD2 and MBD3: characterization of MBD3L1 as a testis-specific transcriptional repressor.
Genomics 2002;80(6):621-9.
2002: Gerd P Pfeifer; Mikhail F Denissenko; Magali Olivier; Natalia Tretyakova; Stephen S Hecht; Pierre Hainaut
Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancers.
Oncogene 2002;21(48):7435-51.
2002: Limin Liu; Jung-Hoon Yoon; Reinhard Dammann; Gerd P Pfeifer
Frequent hypermethylation of the RASSF1A gene in prostate cancer.
Oncogene 2002;21(44):6835-40.
2002: Frank Apostel; Reinhard Dammann; Gerd P Pfeifer; Jobst Greeve
Reduced expression and increased CpG dinucleotide methylation of the rat APOBEC-1 promoter in transgenic rabbits.
Biochimica et biophysica acta 2002;1577(3):384-94.
2002: Dong-Hyun Lee; Timothy R O'Connor; Gerd P Pfeifer
Oxidative DNA damage induced by copper and hydrogen peroxide promotes CG-->TT tandem mutations at methylated CpG dinucleotides in nucleotide excision repair-deficient cells.
Nucleic acids research 2002;30(16):3566-73.
2002: Ahmad Besaratinia; Steven E Bates; Gerd P Pfeifer
Mutational signature of the proximate bladder carcinogen N-hydroxy-4-acetylaminobiphenyl: inconsistency with the p53 mutational spectrum in bladder cancer.
Cancer research 2002;62(15):4331-8.
2002: Undraga Schagdarsurengin; Oliver Gimm; Cuong Hoang-Vu; Henning Dralle; Gerd P Pfeifer; Reinhard Dammann
Frequent epigenetic silencing of the CpG island promoter of RASSF1A in thyroid carcinoma.
Cancer research 2002;62(13):3698-701.
2002: Gerd P Pfeifer; Jung-Hoon Yoon; Limin Liu; Stella Tommasi; Sharon P Wilczynski; Reinhard Dammann
Methylation of the RASSF1A gene in human cancers.
Biological chemistry 2002;383(6):907-14.
2002: Stella Tommasi; Reinhard Dammann; Seung-Gi Jin; Xian-feng Zhang; Joseph Avruch; Gerd P Pfeifer
RASSF3 and NORE1: identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1.
Oncogene 2002;21(17):2713-20.
2002: Moon-shong Tang; Gerd P Pfeifer; Mikhail F Denissenko; Zhaohui Feng; Wenwei Hu; Annie Pao; Yi Zheng; Jessica B Zheng; Haiying Li; James X Chen
Mapping polycyclic aromatic hydrocarbon and aromatic amine-induced DNA damage in cancer-related genes at the sequence level.
International journal of hygiene and environmental health 2002;205(1-2):103-13.
2002: Sara Ortiz-Vega; Andrei Khokhlatchev; Maria Nedwidek; Xian-feng Zhang; Reinhard Dammann; Gerd P Pfeifer; Joseph Avruch
The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1.
Oncogene 2002;21(9):1381-90.
2002: Piroska E Szabó; Jeffrey R Mann; Gerd P Pfeifer
Methylation analysis by chemical DNA sequencing.
Methods in molecular biology (Clifton, N.J.) 2002;200():29-41.
2001: Young-Hyun You; Dong-Hyun Lee; Jung-Hoon Yoon; S Nakajima; A Yasui; Gerd P Pfeifer
Cyclobutane pyrimidine dimers are responsible for the vast majority of mutations induced by UVB irradiation in mammalian cells.
The Journal of biological chemistry 2001;276(48):44688-94.
2001: Jung-Hoon Yoon; Smith Leslie; Z Feng; M Tang; Chong-Soon Lee; Gerd P Pfeifer
Methylated CpG dinucleotides are the preferential targets for G-to-T transversion mutations induced by benzo[a]pyrene diol epoxide in mammalian cells: similarities with the p53 mutation spectrum in smoking-associated lung cancers.
Cancer research 2001;61(19):7110-7.
2001: Reinhard Dammann; T Takahashi; Gerd P Pfeifer
The CpG island of the novel tumor suppressor gene RASSF1A is intensely methylated in primary small cell lung carcinomas.
Oncogene 2001;20(27):3563-7.
2001: Reinhard Dammann; G Yang; Gerd P Pfeifer
Hypermethylation of the cpG island of Ras association domain family 1A (RASSF1A), a putative tumor suppressor gene from the 3p21.3 locus, occurs in a large percentage of human breast cancers.
Cancer research 2001;61(7):3105-9.
2001: J Z Chen; L Smith; Gerd P Pfeifer; Gerald P Holmquist
Fluorescence-based directed termination PCR: direct mutation characterization without sequencing.
Nucleic acids research 2001;29(4):E17.
2001: Young-Hyun You; Gerd P Pfeifer
Similarities in sunlight-induced mutational spectra of CpG-methylated transgenes and the p53 gene in skin cancer point to an important role of 5-methylcytosine residues in solar UV mutagenesis.
Journal of molecular biology 2001;305(3):389-99.
2000: Young-Hyun You; P E Szabó; Gerd P Pfeifer
Cyclobutane pyrimidine dimers form preferentially at the major p53 mutational hotspot in UVB-induced mouse skin tumors.
Carcinogenesis 2000;21(11):2113-7.
2000: Stella Tommasi; A B Oxyzoglou; Gerd P Pfeifer
Cell cycle-independent removal of UV-induced pyrimidine dimers from the promoter and the transcription initiation domain of the human CDC2 gene.
Nucleic acids research 2000;28(20):3991-8.
2000: Piroska E Szabó; Gerd P Pfeifer; Feng Miao; Timothy R O'Connor; Jeffrey R Mann
Improved in vivo dimethyl sulfate footprinting using AlkA protein: DNA-protein interactions at the mouse H19 gene promoter in primary embryo fibroblasts.
Analytical biochemistry 2000;283(1):112-6.
2000: Reinhard Dammann; C Li; Jung-Hoon Yoon; P L Chin; S Bates; Gerd P Pfeifer
Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3.
Nature genetics 2000;25(3):315-9.
2000: Jung-Hoon Yoon; Chong-Soon Lee; Timothy R O'Connor; A Yasui; Gerd P Pfeifer
The DNA damage spectrum produced by simulated sunlight.
Journal of molecular biology 2000;299(3):681-93.
2000: Gerd P Pfeifer
p53 mutational spectra and the role of methylated CpG sequences.
Mutation research 2000;450(1-2):155-66.
2000: Piroska E Szabó; Shih-Huey E Tang; A Rentsendorj; Gerd P Pfeifer; Jeffrey R Mann
Maternal-specific footprints at putative CTCF sites in the H19 imprinting control region give evidence for insulator function.
Current biology : CB 2000;10(10):607-10.
2000: Smith Leslie; Mikhail F Denissenko; Patrick Williams; H Li; Shantu Amin; M Tang; Gerd P Pfeifer
Targeting of lung cancer mutational hotspots by polycyclic aromatic hydrocarbons.
Journal of the National Cancer Institute 2000;92(10):803-11.
2000: Gerd P Pfeifer; M Tang; Mikhail F Denissenko
Mutation hotspots and DNA methylation.
Current topics in microbiology and immunology 2000;249():1-19.
2000: Gerd P Pfeifer; Stella Tommasi
In vivo footprinting using UV light and ligation-mediated PCR.
Methods in molecular biology (Clifton, N.J.) 2000;130():13-27.
1999: Young-Hyun You; C Li; Gerd P Pfeifer
Involvement of 5-methylcytosine in sunlight-induced mutagenesis.
Journal of molecular biology 1999;293(3):493-503.
1999: Stella Tommasi; Gerd P Pfeifer
In vivo structure of two divergent promoters at the human PCNA locus. Synthesis of antisense RNA and S phase-dependent binding of E2F complexes in intron 1.
The Journal of biological chemistry 1999;274(39):27829-38.
1999: Moon-shong Tang; J B Zheng; Mikhail F Denissenko; Gerd P Pfeifer; Y Zheng
Use of UvrABC nuclease to quantify benzo[a]pyrene diol epoxide-DNA adduct formation at methylated versus unmethylated CpG sites in the p53 gene.
Carcinogenesis 1999;20(6):1085-9.
1999: Jung-Hoon Yoon; Piotr M Swiderski; BE Kaplan; M Takao; A Yasui; Binghui Shen; Gerd P Pfeifer
Processing of UV damage in vitro by FEN-1 proteins as part of an alternative DNA excision repair pathway.
Biochemistry 1999;38(15):4809-17.
1999: Mikhail F Denissenko; J Cahill; TB Koudriakova; N Gerber; Gerd P Pfeifer
Quantitation and mapping of aflatoxin B1-induced DNA damage in genomic DNA using aflatoxin B1-8,9-epoxide and microsomal activation systems.
Mutation research 1999;425(2):205-11.
1999: Gerd P Pfeifer; Reinhard Dammann
Measuring the formation and repair of UV photoproducts by ligation-mediated PCR.
Methods in molecular biology (Clifton, N.J.) 1999;113():213-26.
1999: Gerd P Pfeifer; Hsiu-Hua Chen; Jun-ichiro Komura; Arthur D Riggs
Chromatin structure analysis by ligation-mediated and terminal transferase-mediated polymerase chain reaction.
Methods in enzymology 1999;304():548-71.
1998: Gerd P Pfeifer; Mikhail F Denissenko; Moon-shong Tang
PCR-based approaches to adduct analysis.
Toxicology letters 1998;102-103():447-51.
1998: Mikhail F Denissenko; TB Koudriakova; L Smith; Timothy R O'Connor; Arthur D Riggs; Gerd P Pfeifer
The p53 codon 249 mutational hotspot in hepatocellular carcinoma is not related to selective formation or persistence of aflatoxin B1 adducts.
Oncogene 1998;17(23):3007-14.
1998: Y Tu; Reinhard Dammann; Gerd P Pfeifer
Sequence and time-dependent deamination of cytosine bases in UVB-induced cyclobutane pyrimidine dimers in vivo.
Journal of molecular biology 1998;284(2):297-311.
1998: Gerd P Pfeifer; Mikhail F Denissenko; M Tang
p53 mutations, benzo[a]pyrene and lung cancer: a reply.
Mutagenesis 1998;13(6):537-8.
1998: Piroska E Szabó; Gerd P Pfeifer; Jeffrey R Mann
Characterization of novel parent-specific epigenetic modifications upstream of the imprinted mouse H19 gene.
Molecular and cellular biology 1998;18(11):6767-76.
1998: Y Tu; S Bates; Gerd P Pfeifer
The transcription-repair coupling factor CSA is required for efficient repair only during the elongation stages of RNA polymerase II transcription.
Mutation research 1998;400(1-2):143-51.
1998: Mikhail F Denissenko; Annie Pao; Gerd P Pfeifer; M Tang
Slow repair of bulky DNA adducts along the nontranscribed strand of the human p53 gene may explain the strand bias of transversion mutations in cancers.
Oncogene 1998;16(10):1241-7.
1998: Reinhard Dammann; Gerd P Pfeifer
Cloning and characterization of the human RNA polymerase I subunit hRPA40.
Biochimica et biophysica acta 1998;1396(2):153-7.
1998: Gerd P Pfeifer; Mikhail F Denissenko
Formation and repair of DNA lesions in the p53 gene: relation to cancer mutations?
Environmental and molecular mutagenesis 1998;31(3):197-205.
1997: Stella Tommasi; Gerd P Pfeifer
Constitutive protection of E2F recognition sequences in the human thymidine kinase promoter during cell cycle progression.
The Journal of biological chemistry 1997;272(48):30483-90.
1997: Stella Tommasi; Mikhail F Denissenko; Gerd P Pfeifer
Sunlight induces pyrimidine dimers preferentially at 5-methylcytosine bases.
Cancer research 1997;57(21):4727-30.
1997: Y Tu; S Bates; Gerd P Pfeifer
Sequence-specific and domain-specific DNA repair in xeroderma pigmentosum and Cockayne syndrome cells.
The Journal of biological chemistry 1997;272(33):20747-55.
1997: Gerd P Pfeifer; Gerald P Holmquist
Mutagenesis in the P53 gene.
Biochimica et biophysica acta 1997;1333(1):M1-8.
1997: P L Chin; Jamil Momand; Gerd P Pfeifer
In vivo evidence for binding of p53 to consensus binding sites in the p21 and GADD45 genes in response to ionizing radiation.
Oncogene 1997;15(1):87-99.
1997: Mikhail F Denissenko; J X Chen; Moon-shong Tang; Gerd P Pfeifer
Cytosine methylation determines hot spots of DNA damage in the human P53 gene.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(8):3893-8.
1997: Gerd P Pfeifer; S Tornaletti
Footprinting with UV irradiation and LMPCR.
Methods (San Diego, Calif.) 1997;11(2):189-96.
1997: Reinhard Dammann; Gerd P Pfeifer
Lack of gene- and strand-specific DNA repair in RNA polymerase III-transcribed human tRNA genes.
Molecular and cellular biology 1997;17(1):219-29.
1996: Stella Tommasi; P M Swiderski; Y Tu; B E Kaplan; Gerd P Pfeifer
Inhibition of transcription factor binding by ultraviolet-induced pyrimidine dimers.
Biochemistry 1996;35(49):15693-703.
1996: S Tornaletti; S Bates; Gerd P Pfeifer
A high-resolution analysis of chromatin structure along p53 sequences.
Molecular carcinogenesis 1996;17(4):192-201.
1996: Mikhail F Denissenko; A Pao; M Tang; Gerd P Pfeifer
Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53.
Science (New York, N.Y.) 1996;274(5286):430-2.
1996: Gerd P Pfeifer; Arthur D Riggs
Genomic sequencing by ligation-mediated PCR.
Molecular biotechnology 1996;5(3):281-8.
1996: S Tornaletti; Gerd P Pfeifer
UV damage and repair mechanisms in mammalian cells.
BioEssays : news and reviews in molecular, cellular and developmental biology 1996;18(3):221-8.
1996: Y Tu; S Tornaletti; Gerd P Pfeifer
DNA repair domains within a human gene: selective repair of sequences near the transcription initiation site.
The EMBO journal 1996;15(3):675-83.
1995: Stella Tommasi; Gerd P Pfeifer
In vivo structure of the human cdc2 promoter: release of a p130-E2F-4 complex from sequences immediately upstream of the transcription initiation site coincides with induction of cdc2 expression.
Molecular and cellular biology 1995;15(12):6901-13.
1995: S Tornaletti; Gerd P Pfeifer
UV light as a footprinting agent: modulation of UV-induced DNA damage by transcription factors bound at the promoters of three human genes.
Journal of molecular biology 1995;249(4):714-28.
1995: S Tornaletti; Gerd P Pfeifer
Complete and tissue-independent methylation of CpG sites in the p53 gene: implications for mutations in human cancers.
Oncogene 1995;10(8):1493-9.
1995: D Rozek; Gerd P Pfeifer
In vivo protein-DNA interactions at the c-jun promoter in quiescent and serum-stimulated fibroblasts.
Journal of cellular biochemistry 1995;57(3):479-87.
1994: S Tornaletti; D Rozek; Gerd P Pfeifer
Mapping of UV photoproducts along the human P53 gene.
Annals of the New York Academy of Sciences 1994;726():324-6.
1994: S Tornaletti; Gerd P Pfeifer
Slow repair of pyrimidine dimers at p53 mutation hotspots in skin cancer.
Science (New York, N.Y.) 1994;263(5152):1436-8.
1993: D Rozek; Gerd P Pfeifer
In vivo protein-DNA interactions at the c-jun promoter: preformed complexes mediate the UV response.
Molecular and cellular biology 1993;13(9):5490-9.
1993: S Tornaletti; D Rozek; Gerd P Pfeifer
The distribution of UV photoproducts along the human p53 gene and its relation to mutations in skin cancer.
Oncogene 1993;8(8):2051-7.
1993: Gerd P Pfeifer; Régen Drouin; Gerald P Holmquist
Detection of DNA adducts at the DNA sequence level by ligation-mediated PCR.
Mutation research 1993;288(1):39-46.
1993: Gerd P Pfeifer; Arthur D Riggs
Genomic footprinting by ligation mediated polymerase chain reaction.
Methods in molecular biology (Clifton, N.J.) 1993;15():153-68.
1993: Gerd P Pfeifer; A D Riggs
Genomic sequencing.
Methods in molecular biology (Clifton, N.J.) 1993;23():169-81.
1993: Gerd P Pfeifer; Judith Singer-Sam; Arthur D Riggs
Analysis of methylation and chromatin structure.
Methods in enzymology 1993;225():567-83.
1992: Gerd P Pfeifer
Analysis of chromatin structure by ligation-mediated PCR.
PCR methods and applications 1992;2(2):107-11.
1992: V T Törmänen; P M Swiderski; B E Kaplan; Gerd P Pfeifer; Arthur D Riggs
Extension product capture improves genomic sequencing and DNase I footprinting by ligation-mediated PCR.
Nucleic acids research 1992;20(20):5487-8.
1992: V T Törmänen; Gerd P Pfeifer
Mapping of UV photoproducts within ras proto-oncogenes in UV-irradiated cells: correlation with mutations in human skin cancer.
Oncogene 1992;7(9):1729-36.
1992: Arthur D Riggs; Gerd P Pfeifer
X-chromosome inactivation and cell memory.
Trends in genetics : TIG 1992;8(5):169-74.
1992: Gerd P Pfeifer; Régen Drouin; Arthur D Riggs; Gerald P Holmquist
Binding of transcription factors creates hot spots for UV photoproducts in vivo.
Molecular and cellular biology 1992;12(4):1798-804.
1991: Gerd P Pfeifer; Arthur D Riggs
Chromatin differences between active and inactive X chromosomes revealed by genomic footprinting of permeabilized cells using DNase I and ligation-mediated PCR.
Genes & development 1991;5(6):1102-13.
1991: Gerd P Pfeifer; Régen Drouin; Arthur D Riggs; Gerald P Holmquist
In vivo mapping of a DNA adduct at nucleotide resolution: detection of pyrimidine (6-4) pyrimidone photoproducts by ligation-mediated polymerase chain reaction.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(4):1374-8.
1990: Gerd P Pfeifer; S D Steigerwald; R Scott Hansen; Stanley M Gartler; Arthur D Riggs
Polymerase chain reaction-aided genomic sequencing of an X chromosome-linked CpG island: methylation patterns suggest clonal inheritance, CpG site autonomy, and an explanation of activity state stability.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(21):8252-6.
1990: R L Tanguay; Gerd P Pfeifer; Arthur D Riggs
PCR-aided DNaseI footprinting of single copy gene sequences in permeabilized cells.
Nucleic acids research 1990;18(19):5902.
1990: Gerd P Pfeifer; R L Tanguay; S D Steigerwald; Arthur D Riggs
In vivo footprint and methylation analysis by PCR-aided genomic sequencing: comparison of active and inactive X chromosomal DNA at the CpG island and promoter of human PGK-1.
Genes & development 1990;4(8):1277-87.
1990: S D Steigerwald; Gerd P Pfeifer; Arthur D Riggs
Ligation-mediated PCR improves the sensitivity of methylation analysis by restriction enzymes and detection of specific DNA strand breaks.
Nucleic acids research 1990;18(6):1435-9.
1989: Gerd P Pfeifer; S D Steigerwald; Paul R Mueller; B Wold; Arthur D Riggs
Genomic sequencing and methylation analysis by ligation mediated PCR.
Science (New York, N.Y.) 1989;246(4931):810-3.
1989: Gerd P Pfeifer; S D Steigerwald; S Grünwald
The DNA methylation system in proliferating and differentiated cells.
Cell biophysics 1989;15(1-2):79-86.
1989: Thomas Papadopoulos; Gerd P Pfeifer; Florian Hoppe; D Drahovsky; Hans Konrad Müller-Hermelink
Proliferation-associated expression of DNA methyltransferase in human embryonic lung cells.
Virchows Archiv. B, Cell pathology including molecular pathology 1989;56(6):371-5.
1989: Gerd P Pfeifer; L Kohlmaier; A Tomassetti; R Schleicher; Hartmut Follmann; Annie Pfohl-Leszkowicz; G Dirheimer; D Drahovsky
Polypeptide composition and an immunological analysis of DNA methyltransferases from different species.
Archives of biochemistry and biophysics 1989;268(1):388-92.
1988: A Tomassetti; Pablo Hernáiz Driever; Gerd P Pfeifer; D Drahovsky
Isolation and characterization of proteins that stimulate the activity of mammalian DNA methyltransferase.
Biochimica et biophysica acta 1988;951(1):201-12.
1988: E Spiess; A Tomassetti; P Hernaiz-Driever; Gerd P Pfeifer
Structure of mouse DNA (cytosine-5-)-methyltransferase.
European journal of biochemistry / FEBS 1988;177(1):29-34.
1988: Annie Pfohl-Leszkowicz; Gerd P Pfeifer; G Dirheimer
Variations of DNA-(cytosine-5-)-methyltransferase activities after administration of N-hydroxy-N-aminofluorene to Sprague-Dawley rats.
Cancer letters 1988;42(1-2):91-7.
1988: S D Steigerwald; Gerd P Pfeifer
Variable DNA methylation changes during differentiation of human melanoma cells.
Experimental cell research 1988;178(1):41-50.
1988: M C Vogel; Thomas Papadopoulos; Hans Konrad Müller-Hermelink; D Drahovsky; Gerd P Pfeifer
Intracellular distribution of DNA methyltransferase during the cell cycle.
FEBS letters 1988;236(1):9-13.
1988: Gerd P Pfeifer; S Steigerwald; T L Boehm; D Drahovsky
DNA methylation levels in acute human leukemia.
Cancer letters 1988;39(2):185-92.
1988: H Naujoks; J Siracky; D Drahovsky; Gerd P Pfeifer
Immunocytochemical staining of different cell types in vaginal smears by monoclonal anti-DNA methylase antibodies.
Diagnostic cytopathology 1988;4(3):230-3.
1985: Gerd P Pfeifer; S Grünwald; Fabrizio Palitti; S Kaul; T L Boehm; H P Hirth; D Drahovsky
Purification and characterization of mammalian DNA methyltransferases by use of monoclonal antibodies.
The Journal of biological chemistry 1985;260(25):13787-93.
1985: Gerd P Pfeifer; E Spiess; S Grünwald; T L Boehm; D Drahovsky
Mouse DNA-cytosine-5-methyltransferase: sequence specificity of the methylation reaction and electron microscopy of enzyme-DNA complexes.
The EMBO journal 1985;4(11):2879-84.
1985: D Drahovsky; Gerd P Pfeifer; S Grünwald; H P Hirth; M Vogel; M J Brzoska; Fabrizio Palitti
Characterization of DNA methylating enzymes by use of monoclonal antibodies.
Progress in clinical and biological research 1985;198():67-77.
1983: Gerd P Pfeifer; S Grünwald; T L Boehm; D Drahovsky
Isolation and characterization of DNA cytosine 5-methyltransferase from human placenta.
Biochimica et biophysica acta 1983;740(3):323-30.