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Douglas Pfeiffer

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Ricardo Quarrie; Brandon M Cramer; Daniel S Lee; Gregory E Steinbaugh; Warren Erdahl; Douglas R Pfeiffer; Jay L Zweier; Juan A Crestanello
Ischemic preconditioning decreases mitochondrial proton leak and reactive oxygen species production in the postischemic heart.
Nirupama Lal; Jitendra Kumar; Warren E Erdahl; Douglas R Pfeiffer; Martha E Gadd; Gustav Graff; John M Yanni
Differential effects of non-steroidal anti-inflammatory drugs on mitochondrial dysfunction during oxidative stress.
Yeong-Renn Chen; Chwen-Lih Chen; Douglas R Pfeiffer; Jay L Zweier
Mitochondrial complex II in the post-ischemic heart: oxidative injury and the role of protein S-glutathionylation.

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2011: Ricardo Quarrie; Brandon M Cramer; Daniel S Lee; Gregory E Steinbaugh; Warren Erdahl; Douglas R Pfeiffer; Jay L Zweier; Juan A Crestanello
Ischemic preconditioning decreases mitochondrial proton leak and reactive oxygen species production in the postischemic heart.
The Journal of surgical research 2011;165(1):5-14.
2009: Nirupama Lal; Jitendra Kumar; Warren E Erdahl; Douglas R Pfeiffer; Martha E Gadd; Gustav Graff; John M Yanni
Differential effects of non-steroidal anti-inflammatory drugs on mitochondrial dysfunction during oxidative stress.
Archives of biochemistry and biophysics 2009;490(1):1-8.
2007: Yeong-Renn Chen; Chwen-Lih Chen; Douglas R Pfeiffer; Jay L Zweier
Mitochondrial complex II in the post-ischemic heart: oxidative injury and the role of protein S-glutathionylation.
The Journal of biological chemistry 2007;282(45):32640-54.
2006: Shawn A Hamidinia; Warren L Erdahl; Clifford J Chapman; Gregory E Steinbaugh; Richard W Taylor; Douglas R Pfeiffer
Monensin improves the effectiveness of meso-dimercaptosuccinate when used to treat lead intoxication in rats.
Environmental health perspectives 2006;114(4):484-93.
2006: Martha E Gadd; Kimberly M Broekemeier; Elliott D Crouser; Jitendra Kumar; Gustav Graff; Douglas R Pfeiffer
Mitochondrial iPLA2 activity modulates the release of cytochrome c from mitochondria and influences the permeability transition.
The Journal of biological chemistry 2006;281(11):6931-9.
2006: Shawn A Hamidinia; Gregory E Steinbaugh; Warren L Erdahl; Richard W Taylor; Douglas R Pfeiffer
Selective transport of Pb2+ and Cd2+ across a phospholipid bilayer by a cyclohexanemonocarboxylic acid-capped 15-crown-5 ether.
Journal of inorganic biochemistry 2006;100(3):403-12.
2006: Patrick C Bradshaw; Douglas R Pfeiffer
Release of Ca2+ and Mg2+ from yeast mitochondria is stimulated by increased ionic strength.
BMC biochemistry 2006;7():4.
2006: Patrick C Bradshaw; Douglas R Pfeiffer
Loss of NAD(H) from swollen yeast mitochondria.
BMC biochemistry 2006;7():3.
2004: Shawn A Hamidinia; Bo Tan; Warren L Erdahl; Clifford J Chapman; Richard W Taylor; Douglas R Pfeiffer
The ionophore nigericin transports Pb2+ with high activity and selectivity: a comparison to monensin and ionomycin.
Biochemistry 2004;43(50):15956-65.
2004: Elliott D Crouser; Mark W Julian; Jennifer E Huff; Mandar S Joshi; John Anthony Bauer; Martha E Gadd; Mark D Wewers; Douglas R Pfeiffer
Abnormal permeability of inner and outer mitochondrial membranes contributes independently to mitochondrial dysfunction in the liver during acute endotoxemia.
Critical care medicine 2004;32(2):478-88.
2004: DENNIS JUNG; Patrick C Bradshaw; Monica L Litsky; Douglas R Pfeiffer
Ca2+ transport in mitochondria from yeast expressing recombinant aequorin.
Analytical biochemistry 2004;324(2):258-68.
2003: Elliott D Crouser; Martha E Gadd; Mark W Julian; Jennifer E Huff; Kimberly M Broekemeier; Karen A Robbins; Douglas R Pfeiffer
Quantitation of cytochrome c release from rat liver mitochondria.
Analytical biochemistry 2003;317(1):67-75.
2002: Elliott D Crouser; Mark W Julian; Mandar S Joshi; John Anthony Bauer; Mark D Wewers; Judith M Hart; Douglas R Pfeiffer
Cyclosporin A ameliorates mitochondrial ultrastructural injury in the ileum during acute endotoxemia.
Critical care medicine 2002;30(12):2722-8.
2002: Shawn A Hamidinia; Olga I Shimelis; Bo Tan; Warren L Erdahl; Clifford J Chapman; Gordon D Renkes; Richard W Taylor; Douglas R Pfeiffer
Monensin mediates a rapid and selective transport of Pb(2+). Possible application of monensin for the treatment of Pb(2+) intoxication.
The Journal of biological chemistry 2002;277(41):38111-20.
2002: Kimberly M Broekemeier; James R Iben; Emily G LeVan; Elliott D Crouser; Douglas R Pfeiffer
Pore formation and uncoupling initiate a Ca2+-independent degradation of mitochondrial phospholipids.
Biochemistry 2002;41(24):7771-80.
2002: Elliott D Crouser; Mark W Julian; Dorottya V Blaho; Douglas R Pfeiffer
Endotoxin-induced mitochondrial damage correlates with impaired respiratory activity.
Critical care medicine 2002;30(2):276-84.
2001: E Wang; Warren L Erdahl; Shawn A Hamidinia; Clifford J Chapman; Richard W Taylor; Douglas R Pfeiffer
Transport properties of the calcium ionophore ETH-129.
Biophysical journal 2001;81(6):3275-84.
2001: Patrick C Bradshaw; DENNIS JUNG; Douglas R Pfeiffer
Free fatty acids activate a vigorous Ca(2+):2H(+) antiport activity in yeast mitochondria.
The Journal of biological chemistry 2001;276(44):40502-9.
2001: Carmen A Mannella; Douglas R Pfeiffer; Patrick C Bradshaw; Ion I Moraru; Boris M Slepchenko; Leslie M Loew; Chyong-Ere Hsieh; Karolyn F Buttle; Michael Marko
Topology of the mitochondrial inner membrane: dynamics and bioenergetic implications.
IUBMB life 2001;52(3-5):93-100.
2001: Douglas R Pfeiffer; Thomas E Gunter; Roman Eliseev; Kimberly M Broekemeier; Karlene K Gunter
Release of Ca2+ from mitochondria via the saturable mechanisms and the permeability transition.
IUBMB life 2001;52(3-5):205-12.
2000: Warren L Erdahl; Clifford J Chapman; Richard W Taylor; Douglas R Pfeiffer
Ionomycin, a carboxylic acid ionophore, transports Pb(2+) with high selectivity.
The Journal of biological chemistry 2000;275(10):7071-9.
1998: Kimberly M Broekemeier; C K Klocek; Douglas R Pfeiffer
Proton selective substate of the mitochondrial permeability transition pore: regulation by the redox state of the electron transport chain.
Biochemistry 1998;37(38):13059-65.
1998: E Wang; Richard W Taylor; Douglas R Pfeiffer
Mechanism and specificity of lanthanide series cation transport by ionophores A23187, 4-BrA23187, and ionomycin.
Biophysical journal 1998;75(3):1244-54.
1997: DENNIS JUNG; Patrick C Bradshaw; Douglas R Pfeiffer
Properties of a cyclosporin-insensitive permeability transition pore in yeast mitochondria.
The Journal of biological chemistry 1997;272(34):21104-12.
1997: Monica L Litsky; Douglas R Pfeiffer
Regulation of the mitochondrial Ca2+ uniporter by external adenine nucleotides: the uniporter behaves like a gated channel which is regulated by nucleotides and divalent cations.
Biochemistry 1997;36(23):7071-80.
1996: W L Erdahl; C J Chapman; E Wang; R W Taylor; Douglas R Pfeiffer
Ionophore 4-BrA23187 transports Zn2+ and Mn2+ with high selectivity over Ca2+.
Biochemistry 1996;35(43):13817-25.
1996: DENNIS JUNG; C J Chapman; K Baysal; Douglas R Pfeiffer; G P Brierley
On the use of fluorescent probes to estimate free Mg2+ in the matrix of heart mitochondria.
Archives of biochemistry and biophysics 1996;332(1):19-29.
1995: K M Broekemeier; Douglas R Pfeiffer
Inhibition of the mitochondrial permeability transition by cyclosporin A during long time frame experiments: relationship between pore opening and the activity of mitochondrial phospholipases.
Biochemistry 1995;34(50):16440-9.
1995: W L Erdahl; C J Chapman; R W Taylor; Douglas R Pfeiffer
Effects of pH conditions on Ca2+ transport catalyzed by ionophores A23187, 4-BrA23187, and ionomycin suggest problems with common applications of these compounds in biological systems.
Biophysical journal 1995;69(6):2350-63.
1995: Douglas R Pfeiffer; Tatyana I Gudz; Sergei Novgorodov; W L Erdahl
The peptide mastoparan is a potent facilitator of the mitochondrial permeability transition.
The Journal of biological chemistry 1995;270(9):4923-32.
1994: K M Broekemeier; Randy J Krebsbach; Douglas R Pfeiffer
Inhibition of the mitochondrial Ca2+ uniporter by pure and impure ruthenium red.
Molecular and cellular biochemistry 1994;139(1):33-40.
1994: Paolo Bernardi; K M Broekemeier; Douglas R Pfeiffer
Recent progress on regulation of the mitochondrial permeability transition pore; a cyclosporin-sensitive pore in the inner mitochondrial membrane.
Journal of bioenergetics and biomembranes 1994;26(5):509-17.
1994: Sergei Novgorodov; Tatyana I Gudz; G P Brierley; Douglas R Pfeiffer
Magnesium ion modulates the sensitivity of the mitochondrial permeability transition pore to cyclosporin A and ADP.
Archives of biochemistry and biophysics 1994;311(2):219-28.
1994: W L Erdahl; C J Chapman; R W Taylor; Douglas R Pfeiffer
Ca2+ transport properties of ionophores A23187, ionomycin, and 4-BrA23187 in a well defined model system.
Biophysical journal 1994;66(5):1678-93.
1994: J A Gordon; K M Broekemeier; Arthur A Spector; Douglas R Pfeiffer
Mitochondrial metabolism of 12- and 15-hydroxyeicosatetraenoic acids.
Journal of lipid research 1994;35(4):698-708.
1992: K M Broekemeier; L Carpenter-Deyo; D J Reed; Douglas R Pfeiffer
Cyclosporin A protects hepatocytes subjected to high Ca2+ and oxidative stress.
FEBS letters 1992;304(2-3):192-4.
1991: C J Chapman; W E Erdahl; R W Taylor; Douglas R Pfeiffer
Effects of solute concentration on the entrapment of solutes in phospholipid vesicles prepared by freeze-thaw extrusion.
Chemistry and physics of lipids 1991;60(2):201-8.
1991: K M Broekemeier; Patricia C Schmid; M E Dempsey; Douglas R Pfeiffer
Generation of the mitochondrial permeability transition does not involve inhibition of lysophospholipid acylation. Acyl-coenzyme A:1-acyllysophospholipid acyltransferase activity is not found in rat liver mitochondria.
The Journal of biological chemistry 1991;266(31):20700-8.
1991: Urule Igbavboa; Douglas R Pfeiffer
Transient induction of the mitochondrial permeability transition by uncoupler plus a Ca(2+)-specific chelator.
Biochimica et biophysica acta 1991;1059(3):339-47.
1991: M K Stiles; M E Craig; S L Gunnell; Douglas R Pfeiffer; R W Taylor
The formation constants of ionomycin with divalent cations in 80% methanol/water.
The Journal of biological chemistry 1991;266(13):8336-42.
1991: Urule Igbavboa; Douglas R Pfeiffer
Regulation of reverse uniport activity in mitochondria by extramitochondrial divalent cations. Dependence on a soluble intermembrane space component.
The Journal of biological chemistry 1991;266(7):4283-7.
1991: W L Erdahl; Randy J Krebsbach; Douglas R Pfeiffer
A comparison of phospholipid degradation by oxidation and hydrolysis during the mitochondrial permeability transition.
Archives of biochemistry and biophysics 1991;285(2):252-60.
1990: C J Chapman; A K Puri; R W Taylor; Douglas R Pfeiffer
General features in the stoichiometry and stability of ionophore A23187-cation complexes in homogeneous solution.
Archives of biochemistry and biophysics 1990;281(1):44-57.
1990: C J Chapman; W L Erdahl; R W Taylor; Douglas R Pfeiffer
Factors affecting solute entrapment in phospholipid vesicles prepared by the freeze-thaw extrusion method: a possible general method for improving the efficiency of entrapment.
Chemistry and physics of lipids 1990;55(2):73-83.
1989: K M Broekemeier; Douglas R Pfeiffer
Cyclosporin A-sensitive and insensitive mechanisms produce the permeability transition in mitochondria.
Biochemical and biophysical research communications 1989;163(1):561-6.
1989: Urule Igbavboa; C W Zwizinski; Douglas R Pfeiffer
Release of mitochondrial matrix proteins through a Ca2+-requiring, cyclosporin-sensitive pathway.
Biochemical and biophysical research communications 1989;161(2):619-25.
1989: K M Broekemeier; M E Dempsey; Douglas R Pfeiffer
Cyclosporin A is a potent inhibitor of the inner membrane permeability transition in liver mitochondria.
The Journal of biological chemistry 1989;264(14):7826-30.
1988: Urule Igbavboa; Douglas R Pfeiffer
EGTA inhibits reverse uniport-dependent Ca2+ release from uncoupled mitochondria. Possible regulation of the Ca2+ uniporter by a Ca2+ binding site on the cytoplasmic side of the inner membrane.
The Journal of biological chemistry 1988;263(3):1405-12.
1988: Douglas R Pfeiffer; K M Broekemeier; Urule Igbavboa; M Reers; W W Riley
Permeability pathways of Ca2+ efflux from mitochondria: H+ specificity and reversibility of the permeability defect.
Advances in experimental medicine and biology 1988;232():15-23.
1987: M Reers; Douglas R Pfeiffer
Inhibition of mitochondrial phospholipase A2 by mono- and dilysocardiolipin.
Biochemistry 1987;26(25):8038-41.
1987: D F Babcock; Douglas R Pfeiffer
Independent elevation of cytosolic [Ca2+] and pH of mammalian sperm by voltage-dependent and pH-sensitive mechanisms.
The Journal of biological chemistry 1987;262(31):15041-7.
1987: C J Chapman; A K Puri; R W Taylor; Douglas R Pfeiffer
Equilibria between ionophore A23187 and divalent cations: stability of 1:1 complexes in solutions of 80% methanol/water.
Biochemistry 1987;26(16):5009-18.
1986: M Reers; Patricia C Schmid; W L Erdahl; Douglas R Pfeiffer
Separation of phosphatidylethanolamine from its oxidation and hydrolysis products by high-performance liquid chromatography.
Chemistry and physics of lipids 1986;42(4):315-21.
1986: W W Riley; Douglas R Pfeiffer
The effect of Ca2+ and acyl coenzyme A:lysophospholipid acyltransferase inhibitors on permeability properties of the liver mitochondrial inner membrane.
The Journal of biological chemistry 1986;261(30):14018-24.
1986: W W Riley; Douglas R Pfeiffer
Rapid and extensive release of Ca2+ from energized mitochondria induced by EGTA.
The Journal of biological chemistry 1986;261(1):28-31.
1985: W W Riley; Douglas R Pfeiffer
Relationships between Ca2+ release, Ca2+ cycling, and Ca2+-mediated permeability changes in mitochondria.
The Journal of biological chemistry 1985;260(23):12416-25.
1985: K M Broekemeier; Patricia C Schmid; Harald H O Schmid; Douglas R Pfeiffer
Effects of phospholipase A2 inhibitors on ruthenium red-induced Ca2+ release from mitochondria.
The Journal of biological chemistry 1985;260(1):105-13.
1984: M C Beatrice; D L Stiers; Douglas R Pfeiffer
The role of glutathione in the retention of Ca2+ by liver mitochondria.
The Journal of biological chemistry 1984;259(2):1279-87.
1982: M C Beatrice; D L Stiers; Douglas R Pfeiffer
Increased permeability of mitochondria during Ca2+ release induced by t-butyl hydroperoxide or oxalacetate. the effect of ruthenium red.
The Journal of biological chemistry 1982;257(12):7161-71.
1982: D E Epps; J W Palmer; Harald H O Schmid; Douglas R Pfeiffer
Inhibition of permeability-dependent Ca2+ release from mitochondria by N-acylethanolamines, a class of lipids synthesized in ischemic heart tissue.
The Journal of biological chemistry 1982;257(3):1383-91.
1981: M Debono; R M Molloy; D E Dorman; Jonathan Paschal; D F Babcock; C M Deber; Douglas R Pfeiffer
Synthesis and characterization of halogenated derivatives of the ionophore A23187: enhanced calcium ion transport specificity by the 4-bromo derivative.
Biochemistry 1981;20(24):6865-72.
1981: J W Palmer; Patricia C Schmid; Douglas R Pfeiffer; Harald H O Schmid
Lipids and lipolytic enzyme activities of rat heart mitochondria.
Archives of biochemistry and biophysics 1981;211(2):674-82.
1981: J W Palmer; Douglas R Pfeiffer
The control of Ca2+ release from heart mitochondria.
The Journal of biological chemistry 1981;256(13):6742-50.
1981: Patricia C Schmid; Douglas R Pfeiffer; Harald H O Schmid
Quantification of lysophosphatidylethanolamine in the nanomole range.
Journal of lipid research 1981;22(5):882-6.
1981: M C Beatrice; Douglas R Pfeiffer
The mechanism of palmitoyl-CoA inhibition of Ca2+ uptake in liver and heart mitochondria.
The Biochemical journal 1981;194(1):71-7.
1980: M C Beatrice; J W Palmer; Douglas R Pfeiffer
The relationship between mitochondrial membrane permeability, membrane potential, and the retention of Ca2+ by mitochondria.
The Journal of biological chemistry 1980;255(18):8663-71.