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Josef Pfeilschifter

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Patrick Scheiermann; Bernhard Zwissler; Malte Bachmann; Itamar Goren; Josef Pfeilschifter; Heiko Muhl
Application of interleukin-22 mediates protection in experimental acetaminophen-induced acute liver injury.
Kai Doberstein; Wolfgang Eberhardt; Roman Blaheta; Patrick N Harter; Ann-Kathrin Hartmetz; Eva Juengel; Michel Mittelbronn; Josef Pfeilschifter; Nico Steinmeyer; Paul Gutwein
MicroRNA-145 targets the metalloprotease ADAM17 and is suppressed in renal cell carcinoma patients.
Malte Bachmann; Lorena Härdle; Josef Pfeilschifter; Solongo Ulziibat; Heiko Muhl
IFNα converts IL-22 into a cytokine efficiently activating STAT1 and its downstream targets.

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2013: Patrick Scheiermann; Bernhard Zwissler; Malte Bachmann; Itamar Goren; Josef Pfeilschifter; Heiko Muhl
Application of interleukin-22 mediates protection in experimental acetaminophen-induced acute liver injury.
The American journal of pathology 2013;182(4):1107-13.
2013: Kai Doberstein; Wolfgang Eberhardt; Roman Blaheta; Patrick N Harter; Ann-Kathrin Hartmetz; Eva Juengel; Michel Mittelbronn; Josef Pfeilschifter; Nico Steinmeyer; Paul Gutwein
MicroRNA-145 targets the metalloprotease ADAM17 and is suppressed in renal cell carcinoma patients.
Neoplasia (New York, N.Y.) 2013;15(2):218-30.
2013: Malte Bachmann; Lorena Härdle; Josef Pfeilschifter; Solongo Ulziibat; Heiko Muhl
IFNα converts IL-22 into a cytokine efficiently activating STAT1 and its downstream targets.
Biochemical pharmacology 2013;85(3):396-403.
2013: Dagmar Meyer Zu Heringdorf; Katja Ihlefeld; Josef Pfeilschifter
Pharmacology of the sphingosine-1-phosphate signalling system.
Handbook of experimental pharmacology 2013;215():239-53.
2013: Florian Eisel; Heinrich Heide; Karl-Friedrich Beck; Martina Beck; Meike Boosen; Ilka Wittig; Josef Pfeilschifter
Platelet-derived growth factor triggers PKA-mediated signalling by a redox-dependent mechanism in rat renal mesangial cells.
Biochemical pharmacology 2013;85(1):101-8.
2013: Stephanie Schwalm; Josef Pfeilschifter; Andrea Huwiler
Sphingosine-1-phosphate: A Janus-faced mediator of fibrotic diseases.
Biochimica et biophysica acta 2013;1831(1):239-50.
2012: Malte Bachmann; Lorena Härdle; Josef Pfeilschifter; Patrick Scheiermann; Heiko Muhl
IL-36γ/IL-1F9, an innate T-bet target in myeloid cells.
The Journal of biological chemistry 2012;287(50):41684-96.
2012: Peter Natesan Pushparaj; Hwee Kee Tay; Josef Pfeilschifter; Andrea Huwiler
Retraction: Sphingosine kinase1 is pivotal for Fc"RI-mediated mast cell signaling and functional responses in vitro and in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(6):3262.
2012: Mohamed I Hassan; Ramadan A M Hemeida; Jowita Kozlowska; Karl-Friedrich Beck; Martina Beck; Meike Boosen; Florian Eisel; Mohamed A M El-Moselhy; Farid M A Hamada; Liliana Schaefer; Andreas von Knethen; Josef Pfeilschifter
Platelet-derived growth factor-BB induces cystathionine γ-lyase expression in rat mesangial cells via a redox-dependent mechanism.
British journal of pharmacology 2012;166(8):2231-42.
2012: Christoph Schürmann; Cornelia Steinmetz; Kerstin Engelmann-Pilger; Thomas Klein; Andreas Linke; Michael Mark; Josef Pfeilschifter; Stefan Frank
The dipeptidyl peptidase-4 inhibitor linagliptin attenuates inflammation and accelerates epithelialization in wounds of diabetic ob/ob mice.
The Journal of pharmacology and experimental therapeutics 2012;342(1):71-80.
2012: Wolfgang Eberhardt; Anke Doller; Josef Pfeilschifter
Regulation of the mRNA-binding protein HuR by posttranslational modification: spotlight on phosphorylation.
Current protein & peptide science 2012;13(4):380-90.
2012: A Koch; D Meyer zu Heringdorf; A Völzke; C Wünsche; Andrea Huwiler; Josef Pfeilschifter
Thiazolidinedione-dependent activation of sphingosine kinase 1 causes an anti-fibrotic effect in renal mesangial cells.
British journal of pharmacology 2012;166(3):1018-32.
2012: Oliver Seitz; Christoph Schürmann; Stefan Frank; Josef Pfeilschifter; Robert Sader
Identification of the Fra-1 transcription factor in healing skin flaps transplants: a potential role as a negative regulator of VEGF release from keratinocytes.
Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery 2012;40(4):379-86.
2012: Waltraud Pfeilschifter; Helmuth Steinmetz; Peter Baumgarten; Ferdinand Bohmann; Edelgard Lindhoff-Last; Michel Mittelbronn; Josef Pfeilschifter; Christian Foerch
Thrombolysis with recombinant tissue plasminogen activator under dabigatran anticoagulation in experimental stroke.
Annals of neurology 2012;71(5):624-33.
2012: Christian Sadik; Beate Schacher; Heiko Muhl; Birgit Noack; Josef Pfeilschifter; Peter Eickholz
Cytokine production by leukocytes of Papillon-Lefèvre syndrome patients in whole blood cultures.
Clinical oral investigations 2012;16(2):591-7.
2012: Ina Rudloff; Josef Pfeilschifter; Malte Bachmann; Heiko Muhl
Mechanisms of rapid induction of interleukin-22 in activated T cells and its modulation by cyclosporin a.
The Journal of biological chemistry 2012;287(7):4531-43.
2012: Bernd Kronenberger; Malte Bachmann; Friederike Brunner; Natalie Filmann; Eva Herrmann; Lisa Kapper; Josef Pfeilschifter; Albrecht Piiper; Ina Rudloff; Oliver Waidmann; Stefan Zeuzem; Heiko Muhl
Interleukin-22 predicts severity and death in advanced liver cirrhosis: a prospective cohort study.
BMC medicine 2012;10():102.
2012: Ferdinand Bohmann; Christian Foerch; Edelgard Lindhoff-Last; Ana Mirceska; Josef Pfeilschifter; Helmuth Steinmetz; Waltraud Pfeilschifter
No influence of dabigatran anticoagulation on hemorrhagic transformation in an experimental model of ischemic stroke.
PloS one 2012;7(7):e40804.
2012: Miriam Wittmann; Malte Bachmann; Rosella Doble; Josef Pfeilschifter; Thomas Werfel; Heiko Mühl
IL-27 Regulates IL-18 binding protein in skin resident cells.
PloS one 2012;7(6):e38751.
2011: Kai Doberstein; Josef Pfeilschifter; Paul Gutwein
The transcription factor PAX2 regulates ADAM10 expression in renal cell carcinoma.
Carcinogenesis 2011;32(11):1713-23.
2011: Waltraud Pfeilschifter; Abdelhaq Rami; Helmuth Steinmetz; Marian Sujak; Bożena Czech-Zechmeister; Christian Foerch; Andrea Huwiler; Alexander Koch; Ana Mirceska; Josef Pfeilschifter
Activation of sphingosine kinase 2 is an endogenous protective mechanism in cerebral ischemia.
Biochemical and biophysical research communications 2011;413(2):212-7.
2011: Patrick Scheiermann; Sandra Hoegl; Christian Hofstetter; Josef Pfeilschifter; Bernhard Zwissler; Heiko Muhl; Kim A Boost; Bertram Scheller
Comparing hemodynamics, blood gas analyses and proinflammatory cytokines in endotoxemic and severely septic rats.
International immunopharmacology 2011;11(6):719-23.
2011: Anke Doller; Christine Winkler; Irina Azrilian; Sebastian Schulz; Sylvia Hartmann; Josef Pfeilschifter; Wolfgang Eberhardt
High-constitutive HuR phosphorylation at Ser 318 by PKC{delta} propagates tumor relevant functions in colon carcinoma cells.
Carcinogenesis 2011;32(5):676-85.
2011: Heiko Muhl; Malte Bachmann; Josef Pfeilschifter
Inducible NO synthase and antibacterial host defence in times of Th17/Th22/T22 immunity.
Cellular microbiology 2011;13(3):340-8.
2011: Michael Ter Braak; Ralf Frederik Claas; Bianca Hegen; Sandra Labocha; Nerea Ferreirós; Josef Pfeilschifter; Andrea Huwiler; Gerhild van Echten-Deckert; Dagmar Meyer Zu Heringdorf
Cis-4-methylsphingosine is a sphingosine-1-phosphate receptor modulator.
Biochemical pharmacology 2011;81(5):617-25.
2011: Kai Doberstein; Anja Wieland; Sophia B Boyoung Lee; Roman A Alexander Blaheta; Steffen Wedel; Holger Moch; Peter Schraml; Josef Pfeilschifter; Glen Kristiansen; Paul Gutwein
L1-CAM expression in ccRCC correlates with shorter patients survival times and confers chemoresistance in renal cell carcinoma cells.
Carcinogenesis 2011;32(3):262-70.
2011: Sandra Hoegl; Malte Bachmann; Patrick Scheiermann; Itamar Goren; Christian Hofstetter; Josef Pfeilschifter; Bernhard Zwissler; Heiko Muhl
Protective properties of inhaled IL-22 in a model of ventilator-induced lung injury.
American journal of respiratory cell and molecular biology 2011;44(3):369-76.
2011: Rosetta Merline; Kristin Moreth; Madalina V Nastase; Josef Pfeilschifter; Janet Beckmann; Renato V Iozzo; Patricia Lemarchand; Roland M Schaefer; J Guilherme Tralhão; Jinyang Zeng-Brouwers; Liliana Schaefer
Signaling by the matrix proteoglycan decorin controls inflammation and cancer through PDCD4 and MicroRNA-21.
Science signaling 2011;4(199):ra75.
2011: Waltraud Pfeilschifter; Daniel Spitzer; Helmuth Steinmetz; Josef Pfeilschifter; Christian Foerch
Warfarin anticoagulation exacerbates the risk of hemorrhagic transformation after rt-PA treatment in experimental stroke: therapeutic potential of PCC.
PloS one 2011;6(10):e26087.
2011: Sophia Boyoung Lee; Daniela Mihic-Probst; Michel Mittelbronn; Josef Pfeilschifter; Christopher Ungerer; Anja Wieland; Peter Baumgarten; Wolf-Henning Boehncke; Claudia Bürger; Kai Doberstein; Katja Hardt; Paul Gutwein
PAX2 regulates ADAM10 expression and mediates anchorage-independent cell growth of melanoma cells.
PloS one 2011;6(8):e22312.
2011: Waltraud Pfeilschifter; Bożena Czech-Zechmeister; Marian Sujak; Christian Foerch; Thomas A Wichelhaus; Josef Pfeilschifter
Treatment with the immunomodulator FTY720 does not promote spontaneous bacterial infections after experimental stroke in mice.
Experimental & translational stroke medicine 2011;3():2.
2011: Andrea Huwiler; Nataliya Kotelevets; Cuiyan Xin; Oleksandr Pastukhov; Josef Pfeilschifter; Uwe Zangemeister-Wittke
Loss of sphingosine kinase-1 in carcinoma cells increases formation of reactive oxygen species and sensitivity to doxorubicin-induced DNA damage.
British journal of pharmacology 2011;162(2):532-43.
2011: Bashier Ibrahim Osman; El-Sayed Akool; Anke Doller; Roswitha Müller; Josef Pfeilschifter; Wolfgang Eberhardt
Differential modulation of the cytokine-induced MMP-9/TIMP-1 protease-antiprotease system by the mTOR inhibitor rapamycin.
Biochemical pharmacology 2011;81(1):134-43.
2010: Kristin Moreth; Rebekka Brodbeck; Andrea Babelova; Norbert Gretz; Tilmann Spieker; Jinyang Zeng-Brouwers; Josef Pfeilschifter; Marian F Young; Roland M Schaefer; Liliana Schaefer
The proteoglycan biglycan regulates expression of the B cell chemoattractant CXCL13 and aggravates murine lupus nephritis.
The Journal of clinical investigation 2010;120(12):4251-72.
2010: Christopher Ungerer; Kai Doberstein; Claudia Bürger; Katja Hardt; Wolf-Henning Boehncke; Beate Böhm; Josef Pfeilschifter; Reinhard Dummer; Daniela Mihic-Probst; Paul Gutwein
ADAM15 expression is downregulated in melanoma metastasis compared to primary melanoma.
Biochemical and biophysical research communications 2010;401(3):363-9.
2010: Tobias Bingold; Elisabeth Ziesché; Bertram Scheller; Christian Sadik; Katharina Franck; Lara Just; Sven Sartorius; Mathis Wahrmann; Heimo Wissing; Bernhard Zwissler; Josef Pfeilschifter; Heiko Muhl
Interleukin-22 detected in patients with abdominal sepsis.
Shock (Augusta, Ga.) 2010;34(4):337-40.
2010: Waltraud Pfeilschifter; Bozena Czech; Britta P Hoffmann; Marian Sujak; Timo Kahles; Helmuth Steinmetz; Tobias Neumann-Haefelin; Josef Pfeilschifter
Pyrrolidine dithiocarbamate activates p38 MAPK and protects brain endothelial cells from apoptosis: a mechanism for the protective effect in stroke?
Neurochemical research 2010;35(9):1391-401.
2010: Stephanie Schwalm; Josef Pfeilschifter; Andrea Huwiler
Sphingosine kinase 1 is critically involved in nitric oxide-mediated human endothelial cell migration and tube formation.
British journal of pharmacology 2010;160(7):1641-51.
2010: Padmam Puneet; Celestial T Yap; Lingkai Wong; Yulin Lam; Dow-Rhoon Koh; Shabbir Moochhala; Josef Pfeilschifter; Andrea Huwiler; Alirio J Melendez
SphK1 regulates proinflammatory responses associated with endotoxin and polymicrobial sepsis.
Science (New York, N.Y.) 2010;328(5983):1290-4.
2010: Ankathrin Förster; Tanja Emmler; Stephanie Schwalm; Mahsa Ebadi; Dagmar Meyer Zu Heringdorf; Barbara Nieuwenhuis; Burkhard Kleuser; Andrea Huwiler; Josef Pfeilschifter
Glucocorticoids protect renal mesangial cells from apoptosis by increasing cellular sphingosine-1-phosphate.
Kidney international 2010;77(10):870-9.
2010: Anke Doller; Kai Schlepckow; Harald Schwalbe; Josef Pfeilschifter; Wolfgang Eberhardt
Tandem phosphorylation of serines 221 and 318 by protein kinase Cdelta coordinates mRNA binding and nucleocytoplasmic shuttling of HuR.
Molecular and cellular biology 2010;30(6):1397-410.
2010: Andreas Linke; Itamar Goren; Michael R Bösl; Josef Pfeilschifter; Stefan Frank
The suppressor of cytokine signaling (SOCS)-3 determines keratinocyte proliferative and migratory potential during skin repair.
The Journal of investigative dermatology 2010;130(3):876-85.
2010: Andreas Linke; Itamar Goren; Michael R Bösl; Josef Pfeilschifter; Stefan Frank
Epithelial overexpression of SOCS-3 in transgenic mice exacerbates wound inflammation in the presence of elevated TGF-beta1.
The Journal of investigative dermatology 2010;130(3):866-75.
2010: Sophia B Lee; Anja Schramme; Kai Doberstein; Reinhard Dummer; Mohamed S Abdel-Bakky; Sascha Keller; Peter Altevogt; Shin T Oh; Jörg Reichrath; Daniel Oxmann; Josef Pfeilschifter; Daniela Mihic-Probst; Paul Gutwein
ADAM10 is upregulated in melanoma metastasis compared with primary melanoma.
The Journal of investigative dermatology 2010;130(3):763-73.
2010: Josef Pfeilschifter
The Bologna agreement is not suitable for medical education: a German view.
GMS Zeitschrift für medizinische Ausbildung 2010;27(2):Doc32.
2010: Oliver Seitz; Christoph Schürmann; Nadine Hermes; Elke Müller; Josef Pfeilschifter; Stefan Frank; Itamar Goren
Wound healing in mice with high-fat diet- or ob gene-induced diabetes-obesity syndromes: a comparative study.
Experimental diabetes research 2010;2010():476969.
2010: Malte Bachmann; Katharina Horn; Ina Rudloff; Itamar Goren; Martin Holdener; Urs Christen; Nicole Darsow; Klaus-Peter Hunfeld; Ulrike Koehl; Peter Kind; Josef Pfeilschifter; Peter Kraiczy; Heiko Muhl
Early production of IL-22 but not IL-17 by peripheral blood mononuclear cells exposed to live Borrelia burgdorferi: the role of monocytes and interleukin-1.
PLoS pathogens 2010;6(10):e1001144.
2010: Shuyu Ren; Cuiyan Xin; Josef Pfeilschifter; Andrea Huwiler
A novel mode of action of the putative sphingosine kinase inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl) thiazole (SKI II): induction of lysosomal sphingosine kinase 1 degradation.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2010;26(1):97-104.
2010: Paul Gutwein; Anja Schramme; Mohamed Sadek Abdel-Bakky; Kai Doberstein; Ingeborg A Hauser; Andreas Ludwig; Peter Altevogt; Stefan Gauer; Anja Hillmann; Thomas Weide; Christine Jespersen; Wolfgang Eberhardt; Josef Pfeilschifter
ADAM10 is expressed in human podocytes and found in urinary vesicles of patients with glomerular kidney diseases.
Journal of biomedical science 2010;17():3.
2009: Bashier Ibrahim Osman; Anke Doller; El-Sayed Akool; Martin Holdener; Edith Hintermann; Josef Pfeilschifter; Wolfgang Eberhardt
Rapamycin induces the TGFbeta1/Smad signaling cascade in renal mesangial cells upstream of mTOR.
Cellular signalling 2009;21(12):1806-17.
2009: Amany Balah; El-Sayed Akool; Malte Bachmann; Josef Pfeilschifter; Heiko Muhl
The dsRNA-mimetic poly (I:C) and IL-18 synergize for IFNgamma and TNFalpha expression.
Biochemical and biophysical research communications 2009;389(4):628-33.
2009: Bozena Czech; Waltraud Pfeilschifter; Niloufar Mazaheri-Omrani; Marc André Strobel; Timo Kahles; Tobias Neumann-Haefelin; Abdelhaq Rami; Andrea Huwiler; Josef Pfeilschifter
The immunomodulatory sphingosine 1-phosphate analog FTY720 reduces lesion size and improves neurological outcome in a mouse model of cerebral ischemia.
Biochemical and biophysical research communications 2009;389(2):251-6.
2009: R Merline; S Lazaroski; Andrea Babelova; W Tsalastra-Greul; Josef Pfeilschifter; K D Schluter; A Gunther; Renato V Iozzo; Roland M Schaefer; Liliana Schaefer
Decorin deficiency in diabetic mice: aggravation of nephropathy due to overexpression of profibrotic factors, enhanced apoptosis and mononuclear cell infiltration.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2009;60 Suppl 4():5-13.
2009: Shuyu Ren; Andrea Babelova; Kristin Moreth; Cuiyan Xin; Wolfgang Eberhardt; Anke Doller; Hermann Pavenstädt; Liliana Schaefer; Josef Pfeilschifter; Andrea Huwiler
Transforming growth factor-beta2 upregulates sphingosine kinase-1 activity, which in turn attenuates the fibrotic response to TGF-beta2 by impeding CTGF expression.
Kidney international 2009;76(8):857-67.
2009: Andrea Huwiler; Josef Pfeilschifter
Lipids as targets for novel anti-inflammatory therapies.
Pharmacology & therapeutics 2009;124(1):96-112.
2009: Andrea Babelova; Kristin Moreth; Wasiliki Tsalastra-Greul; Jinyang Zeng-Brouwers; Oliver Eickelberg; Marian F Young; Peter Bruckner; Josef Pfeilschifter; Roland M Schaefer; Hermann-Josef Gröne; Liliana Schaefer
Biglycan, a danger signal that activates the NLRP3 inflammasome via toll-like and P2X receptors.
The Journal of biological chemistry 2009;284(36):24035-48.
2009: Ellen Dreieicher; Karl-Friedrich Beck; Sandra Lazaroski; Meike Boosen; Wasiliki Tsalastra-Greul; Martina Beck; Ingrid Fleming; Liliana Schaefer; Josef Pfeilschifter
Nitric oxide inhibits glomerular TGF-beta signaling via SMOC-1.
Journal of the American Society of Nephrology : JASN 2009;20(9):1963-74.
2009: Paul Gutwein; Mohamed Sadek Abdel-Bakky; Kai Doberstein; Anja Schramme; Janet Beckmann; Liliana Schaefer; Kerstin Amann; Anke Doller; Nicole Kämpfer-Kolb; Abdel-Aziz H Abdel-Aziz; El Sayed M El Sayed; Josef Pfeilschifter
CXCL16 and oxLDL are induced in the onset of diabetic nephropathy.
Journal of cellular and molecular medicine 2009;13(9B):3809-25.
2009: Christian Sadik; Malte Bachmann; Josef Pfeilschifter; Heiko Muhl
Activation of interferon regulatory factor-3 via toll-like receptor 3 and immunomodulatory functions detected in A549 lung epithelial cells exposed to misplaced U1-snRNA.
Nucleic acids research 2009;37(15):5041-56.
2009: Malte Bachmann; Jens Paulukat; Josef Pfeilschifter; Heiko Muhl
Molecular mechanisms of IL-18BP regulation in DLD-1 cells: pivotal direct action of the STAT1/GAS axis on the promoter level.
Journal of cellular and molecular medicine 2009;13(8B):1987-94.
2009: Peter Natesan Pushparaj; Manikandan Jayapal; Hwee Kee Tay; Shiau Chen H'ng; Srinivasan D Kumar; Josef Pfeilschifter; Andrea Huwiler; Alirio J Melendez
Sphingosine kinase 1 is pivotal for Fc epsilon RI-mediated mast cell signaling and functional responses in vitro and in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(1):221-7.
2009: Itamar Goren; Nadine Allmann; Nir Yogev; Christoph Schürmann; Andreas Linke; Martin Holdener; Ari Waisman; Josef Pfeilschifter; Stefan Frank
A transgenic mouse model of inducible macrophage depletion: effects of diphtheria toxin-driven lysozyme M-specific cell lineage ablation on wound inflammatory, angiogenic, and contractive processes.
The American journal of pathology 2009;175(1):132-47.
2009: Paul Gutwein; Mohamed Sadek Abdel-Bakky; Anja Schramme; Kai Doberstein; Nicole Kämpfer-Kolb; Kerstin Amann; Ingeborg A Hauser; Nicholas Obermüller; Christine Bartel; Abdel-Aziz H Abdel-Aziz; El Sayed M El Sayed; Josef Pfeilschifter
CXCL16 is expressed in podocytes and acts as a scavenger receptor for oxidized low-density lipoprotein.
The American journal of pathology 2009;174(6):2061-72.
2009: Barbara Nieuwenhuis; Anja Lüth; Jerold Chun; Andrea Huwiler; Josef Pfeilschifter; Monika Schäfer-Korting; Burkhard Kleuser
Involvement of the ABC-transporter ABCC1 and the sphingosine 1-phosphate receptor subtype S1P(3) in the cytoprotection of human fibroblasts by the glucocorticoid dexamethasone.
Journal of molecular medicine (Berlin, Germany) 2009;87(6):645-57.
2009: Christine Jespersen; Anke Doller; El-Sayed Akool; Malte Bachmann; Roswitha Müller; Paul Gutwein; Heiko Muhl; Josef Pfeilschifter; Wolfgang Eberhardt
Molecular mechanisms of nitric oxide-dependent inhibition of TPA-induced matrix metalloproteinase-9 (MMP-9) in MCF-7 cells.
Journal of cellular physiology 2009;219(2):276-87.
2009: Susanne Alban; Ralf J Ludwig; Gerd Bendas; Michael P Schön; Gertie J Oostingh; Heinfried H Radeke; Juliane Fritzsche; Josef Pfeilschifter; Roland Kaufmann; Wolf-Henning Boehncke
PS3, a semisynthetic beta-1,3-glucan sulfate, diminishes contact hypersensitivity responses through inhibition of L- and P-selectin functions.
The Journal of investigative dermatology 2009;129(5):1192-202.
2009: Anke Doller; Stefan Gauer; Ewelina Sobkowiak; Helmut Geiger; Josef Pfeilschifter; Wolfgang Eberhardt
Angiotensin II induces renal plasminogen activator inhibitor-1 and cyclooxygenase-2 expression post-transcriptionally via activation of the mRNA-stabilizing factor human-antigen R.
The American journal of pathology 2009;174(4):1252-63.
2009: Paul Gutwein; Anja Schramme; Beren Voss; Mohamed Sadek Abdel-Bakky; Kai Doberstein; Andreas Ludwig; Peter Altevogt; Martin-Leo Hansmann; Holger Moch; Glen Kristiansen; Josef Pfeilschifter
Downregulation of junctional adhesion molecule-A is involved in the progression of clear cell renal cell carcinoma.
Biochemical and biophysical research communications 2009;380(2):387-91.
2009: Christoph Schürmann; Oliver Seitz; Cornelius Klein; Robert Sader; Josef Pfeilschifter; Heiko Muhl; Itamar Goren; Stefan Frank
Tight spatial and temporal control in dynamic basal to distal migration of epithelial inflammatory responses and infiltration of cytoprotective macrophages determine healing skin flap transplants in mice.
Annals of surgery 2009;249(3):519-34.
2009: Itamar Goren; Elke Müller; Dana Schiefelbein; Paul Gutwein; Oliver Seitz; Josef Pfeilschifter; Stefan Frank
Akt1 controls insulin-driven VEGF biosynthesis from keratinocytes: implications for normal and diabetes-impaired skin repair in mice.
The Journal of investigative dermatology 2009;129(3):752-64.
2009: Paul Gutwein; Anja Schramme; Nina Sinke; Mohamed Sadek Abdel-Bakky; Beren Voss; Nicholas Obermüller; Kai Doberstein; Michael Koziolek; Florian Fritzsche; Manfred Johannsen; Klaus Jung; Helmut Schaider; Peter Altevogt; Andreas Ludwig; Josef Pfeilschifter; Glen Kristiansen
Tumoural CXCL16 expression is a novel prognostic marker of longer survival times in renal cell cancer patients.
European journal of cancer (Oxford, England : 1990) 2009;45(3):478-89.
2008: Anke Doller; Josef Pfeilschifter; Wolfgang Eberhardt
Signalling pathways regulating nucleo-cytoplasmic shuttling of the mRNA-binding protein HuR.
Cellular signalling 2008;20(12):2165-73.
2008: Lotte P Hofmann; Shuyu Ren; Stephanie Schwalm; Josef Pfeilschifter; Andrea Huwiler
Sphingosine kinase 1 and 2 regulate the capacity of mesangial cells to resist apoptotic stimuli in an opposing manner.
Biological chemistry 2008;389(11):1399-407.
2008: Dana Schiefelbein; Oliver Seitz; Itamar Goren; Jan Philipp Dissmann; Helmut Schmidt; Malte Bachmann; Robert Sader; Gerd Geisslinger; Josef Pfeilschifter; Stefan Frank
Keratinocyte-derived vascular endothelial growth factor biosynthesis represents a pleiotropic side effect of peroxisome proliferator-activated receptor-gamma agonist troglitazone but not rosiglitazone and involves activation of p38 mitogen-activated protein kinase: implications for diabetes-impaired skin repair.
Molecular pharmacology 2008;74(4):952-63.
2008: El-Sayed Akool; Anke Doller; Andrea Babelova; Wasiliki Tsalastra; Kristin Moreth; Liliana Schaefer; Josef Pfeilschifter; Wolfgang Eberhardt
Molecular mechanisms of TGF beta receptor-triggered signaling cascades rapidly induced by the calcineurin inhibitors cyclosporin A and FK506.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(4):2831-45.
2008: Anja Schramme; Mohamed Sadek Abdel-Bakky; Paul Gutwein; Nicholas Obermüller; Patrick Baer; Ingeborg A Hauser; Andreas Ludwig; Stefan Gauer; Liliana Schäfer; Ewelina Sobkowiak; Peter Altevogt; Michael Koziolek; Eva Kiss; Hermann-Josef Gröne; Ritva Tikkanen; Itamar Goren; Heinfried Radeke; Josef Pfeilschifter
Characterization of CXCL16 and ADAM10 in the normal and transplanted kidney.
Kidney international 2008;74(3):328-38.
2008: Itamar Goren; Elke Müller; Josef Pfeilschifter; Stefan Frank
Thr308 determines Akt1 nuclear localization in insulin-stimulated keratinocytes.
Biochemical and biophysical research communications 2008;372(1):103-7.
2008: Laure Janot; Thomas Secher; David Torres; Isabelle Maillet; Josef Pfeilschifter; Valerie QUESNIAUX; Regine Landmann; Bernhard RYFFEL; François Erard
CD14 works with toll-like receptor 2 to contribute to recognition and control of Listeria monocytogenes infection.
The Journal of infectious diseases 2008;198(1):115-24.
2008: Martin Holdener; Edith Hintermann; Monika Bayer; Antje Rhode; Evelyn Rodrigo; Gudrun Hintereder; Eric F Johnson; Frank J Gonzalez; Josef Pfeilschifter; Michael P Manns; Matthias von G Herrath; Urs Christen
Breaking tolerance to the natural human liver autoantigen cytochrome P450 2D6 by virus infection.
The Journal of experimental medicine 2008;205(6):1409-22.
2008: Dana Schiefelbein; Itamar Goren; Beate Fisslthaler; Helmut Schmidt; Gerd Geisslinger; Josef Pfeilschifter; Stefan Frank
Biphasic regulation of HMG-CoA reductase expression and activity during wound healing and its functional role in the control of keratinocyte angiogenic and proliferative responses.
The Journal of biological chemistry 2008;283(22):15479-90.
2008: Anja Schramme; Mohamed Sadek Abdel-Bakky; Nicole Kämpfer-Kolb; Josef Pfeilschifter; Paul Gutwein
The role of CXCL16 and its processing metalloproteinases ADAM10 and ADAM17 in the proliferation and migration of human mesangial cells.
Biochemical and biophysical research communications 2008;370(2):311-6.
2008: Andrea Huwiler; Josef Pfeilschifter
New players on the center stage: sphingosine 1-phosphate and its receptors as drug targets.
Biochemical pharmacology 2008;75(10):1893-900.
2008: Marco A Poleganov; Malte Bachmann; Josef Pfeilschifter; Heiko Muhl
Genome-wide analysis displays marked induction of EBI3/IL-27B in IL-18-activated AML-derived KG1 cells: critical role of two kappaB binding sites in the human EBI3 promotor.
Molecular immunology 2008;45(10):2869-80.
2008: Stephanie Schwalm; Frauke Döll; Isolde Römer; Svetlana Bubnova; Josef Pfeilschifter; Andrea Huwiler
Sphingosine kinase-1 is a hypoxia-regulated gene that stimulates migration of human endothelial cells.
Biochemical and biophysical research communications 2008;368(4):1020-5.
2008: Sandra Hoegl; Kim A Boost; Michael Flondor; Patrick Scheiermann; Heiko Muhl; Josef Pfeilschifter; Bernhard Zwissler; Christian Hofstetter
Short-term exposure to high-pressure ventilation leads to pulmonary biotrauma and systemic inflammation in the rat.
International journal of molecular medicine 2008;21(4):513-9.
2008: Anke Doller; El-Sayed Akool; Andrea Huwiler; Roswitha Müller; Heinfried Radeke; Josef Pfeilschifter; Wolfgang Eberhardt
Posttranslational modification of the AU-rich element binding protein HuR by protein kinase Cdelta elicits angiotensin II-induced stabilization and nuclear export of cyclooxygenase 2 mRNA.
Molecular and cellular biology 2008;28(8):2608-25.
2008: Kim A Boost; Christian Sadik; Malte Bachmann; Bernhard Zwissler; Josef Pfeilschifter; Heiko Muhl
IFN-gamma impairs release of IL-8 by IL-1beta-stimulated A549 lung carcinoma cells.
BMC cancer 2008;8():265.
2008: Christian Sadik; Klaus-Peter Hunfeld; Malte Bachmann; Peter Kraiczy; Wolfgang Eberhardt; Volker Brade; Josef Pfeilschifter; Heiko Muhl
Systematic analysis highlights the key role of TLR2/NF-kappaB/MAP kinase signaling for IL-8 induction by macrophage-like THP-1 cells under influence of Borrelia burgdorferi lysates.
The international journal of biochemistry & cell biology 2008;40(11):2508-21.
2007: Marco A Poleganov; Josef Pfeilschifter; Heiko Muhl
Expanding extracellular zinc beyond levels reflecting the albumin-bound plasma zinc pool potentiates the capability of IL-1beta, IL-18, and IL-12 to Act as IFN-gamma-inducing factors on PBMC.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2007;27(12):997-1001.
2007: Marcel Nold; Claudia Nold-Petry; Doris Fischer; Bernd Richter; Roman A Blaheta; Josef Pfeilschifter; Heiko Muhl; Dietmar Schranz; Alex Veldman
Activated protein C downregulates p38 mitogen-activated protein kinase and improves clinical parameters in an in-vivo model of septic shock.
Thrombosis and haemostasis 2007;98(5):1118-26.
2007: Stefan Gauer; O Sichler; Nicholas Obermüller; Y Holzmann; E Kiss; E Sobkowiak; Josef Pfeilschifter; Helmut Geiger; Heiko Muhl; Ingeborg A Hauser
IL-18 is expressed in the intercalated cell of human kidney.
Kidney international 2007;72(9):1081-7.
2007: Christian Hofstetter; Kim A Boost; Sandra Hoegl; Michael Flondor; Bertram Scheller; Heiko Muhl; Josef Pfeilschifter; Bernhard Zwissler
Norepinephrine and vasopressin counteract anti-inflammatory effects of isoflurane in endotoxemic rats.
International journal of molecular medicine 2007;20(4):597-604.
2007: Cuiyan Xin; Shuyu Ren; Wolfgang Eberhardt; Josef Pfeilschifter; Andrea Huwiler
Sphingosylphosphorylcholine acts in an anti-inflammatory manner in renal mesangial cells by reducing interleukin-1beta-induced prostaglandin E2 formation.
Journal of lipid research 2007;48(9):1985-96.
2007: Itamar Goren; Elke Müller; Dana Schiefelbein; Urs Christen; Josef Pfeilschifter; Heiko Muhl; Stefan Frank
Systemic anti-TNFalpha treatment restores diabetes-impaired skin repair in ob/ob mice by inactivation of macrophages.
The Journal of investigative dermatology 2007;127(9):2259-67.
2007: Maren Luchtefeld; Nele Bandlow; Uwe J F Tietge; Karsten Grote; Josef Pfeilschifter; Marietta Kaszkin; Sabine Beck; Helmut Drexler; Bernhard Schieffer
Angiotensin II type 1-receptor antagonism prevents type IIA secretory phospholipase A2-dependent lipid peroxidation.
Atherosclerosis 2007;194(1):62-70.
2007: W Eberhardt; Josef Pfeilschifter
Nitric oxide and vascular remodeling: spotlight on the kidney.
Kidney international. Supplement 2007;(106):S9-S16.
2007: Christian Hofstetter; Kim A Boost; Michael Flondor; E Basagan-Mogol; Christoph Betz; Markus Homann; Heiko Muhl; Josef Pfeilschifter; Bernhard Zwissler
Anti-inflammatory effects of sevoflurane and mild hypothermia in endotoxemic rats.
Acta anaesthesiologica Scandinavica 2007;51(7):893-9.
2007: Frauke Döll; Josef Pfeilschifter; Andrea Huwiler
Prolactin upregulates sphingosine kinase-1 expression and activity in the human breast cancer cell line MCF7 and triggers enhanced proliferation and migration.
Endocrine-related cancer 2007;14(2):325-35.
2007: Elisabeth Ziesché; Malte Bachmann; Hartmut Kleinert; Josef Pfeilschifter; Heiko Muhl
The interleukin-22/STAT3 pathway potentiates expression of inducible nitric-oxide synthase in human colon carcinoma cells.
The Journal of biological chemistry 2007;282(22):16006-15.
2007: Anke Doller; Andrea Huwiler; Roswitha Müller; Heinfried Radeke; Josef Pfeilschifter; Wolfgang Eberhardt
Protein kinase C alpha-dependent phosphorylation of the mRNA-stabilizing factor HuR: implications for posttranscriptional regulation of cyclooxygenase-2.
Molecular biology of the cell 2007;18(6):2137-48.
2007: Kim A Boost; Sandra Hoegl; Christian Hofstetter; Michael Flondor; Klaus Stegewerth; Ilka Platacis; Josef Pfeilschifter; Heiko Muhl; Bernhard Zwissler
Targeting caspase-1 by inhalation-therapy: effects of Ac-YVAD-CHO on IL-1 beta, IL-18 and downstream proinflammatory parameters as detected in rat endotoxaemia.
Intensive care medicine 2007;33(5):863-71.
2007: Wolfgang Schacke; Karl-Friedrich Beck; Josef Pfeilschifter; Lars-Olof Hattenbach
Expression of ubiquitin carboxy-terminal hydrolase-l1 in photocoagulated human retinal pigment epithelial cells.
Current eye research 2007;32(4):367-72.
2007: Cuiyan Xin; Shuyu Ren; Wolfgang Eberhardt; Josef Pfeilschifter; Andrea Huwiler
FTY720 suppresses interleukin-1beta-induced secretory phospholipase A2 expression in renal mesangial cells by a transcriptional mechanism.
British journal of pharmacology 2007;150(7):943-50.
2007: Wolfgang Eberhardt; Anke Doller; El-Sayed Akool; Josef Pfeilschifter
Modulation of mRNA stability as a novel therapeutic approach.
Pharmacology & therapeutics 2007;114(1):56-73.
2007: Malte Bachmann; Cristina Dragoi; Marco A Poleganov; Josef Pfeilschifter; Heiko Muhl
Interleukin-18 directly activates T-bet expression and function via p38 mitogen-activated protein kinase and nuclear factor-kappaB in acute myeloid leukemia-derived predendritic KG-1 cells.
Molecular cancer therapeutics 2007;6(2):723-31.
2007: Anke Doller; El-Sayed Akool; Roswitha Müller; Paul Gutwein; Christine Kurowski; Josef Pfeilschifter; Wolfgang Eberhardt
Molecular mechanisms of cyclosporin A inhibition of the cytokine-induced matrix metalloproteinase-9 in glomerular mesangial cells.
Journal of the American Society of Nephrology : JASN 2007;18(2):581-92.
2007: S Klawitter; L P Hofmann; Josef Pfeilschifter; Andrea Huwiler
Extracellular nucleotides induce migration of renal mesangial cells by upregulating sphingosine kinase-1 expression and activity.
British journal of pharmacology 2007;150(3):271-80.
2007: Liliana Schaefer; Wasiliki Tsalastra; Andrea Babelova; Martina Baliova; Jens Minnerup; Lydia Sorokin; Hermann-Josef Gröne; Ehab Ismail El=-Hallous; Josef Pfeilschifter; Renato V Iozzo; Roland M Schaefer
Decorin-mediated regulation of fibrillin-1 in the kidney involves the insulin-like growth factor-I receptor and Mammalian target of rapamycin.
The American journal of pathology 2007;170(1):301-15.
2006: Andrea Huwiler; Josef Pfeilschifter
Hypoxia and lipid signaling.
Biological chemistry 2006;387(10-11):1321-8.
2006: S Beck; G Beck; Tammo Ostendorf; J Floege; Gérard Lambeau; T Nevalainen; Heinfried Radeke; Silvia Gurrieri; Ulrike Haas; B Thorwart; Josef Pfeilschifter; Marietta Kaszkin
Upregulation of group IB secreted phospholipase A(2) and its M-type receptor in rat ANTI-THY-1 glomerulonephritis.
Kidney international 2006;70(7):1251-60.
2006: Kim A Boost; Christian Hofstetter; Michael Flondor; Christoph Betz; Markus Homann; Josef Pfeilschifter; Heiko Muhl; Bernhard Zwissler
Desflurane differentially affects the release of proinflammatory cytokines in plasma and bronchoalveolar fluid of endotoxemic rats.
International journal of molecular medicine 2006;17(6):1139-44.
2006: Heiko Muhl; Josef Pfeilschifter
Controlling the cytokine storm by insulin: glycogen synthase kinase-3 as a target in systemic inflammation.
Critical care medicine 2006;34(5):1567-9.
2006: Andrea Huwiler; Frauke Döll; Shuyu Ren; Sabine Klawitter; Anna Greening; Isolde Römer; Svetlana Bubnova; Luise Reinsberg; Josef Pfeilschifter
Histamine increases sphingosine kinase-1 expression and activity in the human arterial endothelial cell line EA.hy 926 by a PKC-alpha-dependent mechanism.
Biochimica et biophysica acta 2006;1761(3):367-76.
2006: Itamar Goren; Elke Müller; Josef Pfeilschifter; Stefan Frank
Severely impaired insulin signaling in chronic wounds of diabetic ob/ob mice: a potential role of tumor necrosis factor-alpha.
The American journal of pathology 2006;168(3):765-77.
2006: Itamar Goren; Heiko Kämpfer; Elke Müller; Dana Schiefelbein; Josef Pfeilschifter; Stefan Frank
Oncostatin M expression is functionally connected to neutrophils in the early inflammatory phase of skin repair: implications for normal and diabetes-impaired wounds.
The Journal of investigative dermatology 2006;126(3):628-37.
2006: Malte Bachmann; Katharina Horn; Marco A Poleganov; Jens Paulukat; Marcel Nold; Josef Pfeilschifter; Heiko Muhl
Interleukin-18 secretion and Th1-like cytokine responses in human peripheral blood mononuclear cells under the influence of the toll-like receptor-5 ligand flagellin.
Cellular microbiology 2006;8(2):289-300.
2006: Itamar Goren; Andreas Linke; Elke Müller; Josef Pfeilschifter; Stefan Frank
The suppressor of cytokine signaling-3 is upregulated in impaired skin repair: implications for keratinocyte proliferation.
The Journal of investigative dermatology 2006;126(2):477-85.
2006: Andrea Huwiler; Josef Pfeilschifter
Altering the sphingosine-1-phosphate/ceramide balance: a promising approach for tumor therapy.
Current pharmaceutical design 2006;12(35):4625-35.
2006: Cuiyan Xin; Shuyu Ren; Wolfgang Eberhardt; Josef Pfeilschifter; Andrea Huwiler
The immunomodulator FTY720 and its phosphorylated derivative activate the Smad signalling cascade and upregulate connective tissue growth factor and collagen type IV expression in renal mesangial cells.
British journal of pharmacology 2006;147(2):164-74.
2006: Miriam Plesková; Karl-Friedrich Beck; Meik Helmut Behrens; Andrea Huwiler; Birgit Fichtlscherer; Oliver Wingerter; Ralf P Brandes; Alexander Mülsch; Josef Pfeilschifter
Nitric oxide down-regulates the expression of the catalytic NADPH oxidase subunit Nox1 in rat renal mesangial cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(1):139-41.
2005: Frauke Döll; Josef Pfeilschifter; Andrea Huwiler
The epidermal growth factor stimulates sphingosine kinase-1 expression and activity in the human mammary carcinoma cell line MCF7.
Biochimica et biophysica acta 2005;1738(1-3):72-81.
2005: Shuyu Ren; Cuiyan Xin; Karl-Friedrich Beck; Moin A Saleem; Peter Mathieson; Hermann Pavenstädt; Josef Pfeilschifter; Andrea Huwiler
PPARalpha activation upregulates nephrin expression in human embryonic kidney epithelial cells and podocytes by a dual mechanism.
Biochemical and biophysical research communications 2005;338(4):1818-24.
2005: El-Sayed Akool; Anke Doller; Roswitha Müller; Paul Gutwein; Cuiyan Xin; Andrea Huwiler; Josef Pfeilschifter; Wolfgang Eberhardt
Nitric oxide induces TIMP-1 expression by activating the transforming growth factor beta-Smad signaling pathway.
The Journal of biological chemistry 2005;280(47):39403-16.
2005: Lars-Olof Hattenbach; Karl-Friedrich Beck; Josef Pfeilschifter; Frank Koch; Christian Ohrloff; Wolfgang Schacke
Pigment-epithelium-derived factor is upregulated in photocoagulated human retinal pigment epithelial cells.
Ophthalmic research 2005;37(6):341-6.
2005: Claudia Nold-Petry; Andrea Huwiler; Wolfgang Eberhardt; Marietta Kaszkin; Josef Pfeilschifter
Hypoxia increases group IIA phospholipase A(2) expression under inflammatory conditions in rat renal mesangial cells.
Journal of the American Society of Nephrology : JASN 2005;16(10):2897-905.
2005: Christian Hofstetter; Michael Flondor; Kim A Boost; Patricia Koehler; Markus Bosmann; Josef Pfeilschifter; Bernhard Zwissler; Heiko Muhl
A brief exposure to isoflurane (50 s) significantly impacts on plasma cytokine levels in endotoxemic rats.
International immunopharmacology 2005;5(10):1519-22.
2005: Wolfgang Eberhardt; Tobias Kilz; El-Sayed Akool; Roswitha Müller; Josef Pfeilschifter
Dissociated glucocorticoids equipotently inhibit cytokine- and cAMP-induced matrix degrading proteases in rat mesangial cells.
Biochemical pharmacology 2005;70(3):433-45.
2005: Karl-Friedrich Beck; Gülmisal Güder; Liliana Schaefer; Miriam Pleskova; Andrea Babelova; Meik Helmut Behrens; Daniel Mihalik; Martina Beck; Roland M Schaefer; Josef Pfeilschifter
Nitric oxide upregulates induction of PDGF receptor-alpha expression in rat renal mesangial cells and in anti-Thy-1 glomerulonephritis.
Journal of the American Society of Nephrology : JASN 2005;16(7):1948-57.
2005: G J Vlachojannis; Kristen Scholz-Pedretti; W Fierlbeck; H Geiger; Josef Pfeilschifter; Marietta Kaszkin
Enhanced expression of group IIA secreted phospholipase A2 by elevated glucose levels in cytokine-stimulated rat mesangial cells and in kidneys of diabetic rats.
Clinical nephrology 2005;63(5):356-67.
2005: Heiko Kämpfer; Ronald Schmidt; Gerd Geisslinger; Josef Pfeilschifter; Stefan Frank
Wound inflammation in diabetic ob/ob mice: functional coupling of prostaglandin biosynthesis to cyclooxygenase-1 activity in diabetes-impaired wound healing.
Diabetes 2005;54(5):1543-51.
2005: Talija Djordjevic; Rachida S BelAiba; Steve Bonello; Josef Pfeilschifter; John Hess; Agnes Görlach
Human urotensin II is a novel activator of NADPH oxidase in human pulmonary artery smooth muscle cells.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(3):519-25.
2005: Ulrike Haas; Maurizio Podda; Martin Behne; Silvia Gurrieri; Angel Alonso; Gerhard Fürstenberger; Josef Pfeilschifter; Gérard Lambeau; Michael H Gelb; Marietta Kaszkin
Characterization and differentiation-dependent regulation of secreted phospholipases A in human keratinocytes and in healthy and psoriatic human skin.
The Journal of investigative dermatology 2005;124(1):204-11.
2004: Mei Sun; Lingxin Kong; Xiaodan Wang; Courtney Holmes; Qingsheng Gao; Guo-Rong Zhang; Josef Pfeilschifter; David S Goldstein; Alfred I Geller
Coexpression of tyrosine hydroxylase, GTP cyclohydrolase I, aromatic amino acid decarboxylase, and vesicular monoamine transporter 2 from a helper virus-free herpes simplex virus type 1 vector supports high-level, long-term biochemical and behavioral correction of a rat model of Parkinson's disease.
Human gene therapy 2004;15(12):1177-96.
2004: Heiko Muhl; Jens Paulukat; Sonja Höfler; Markus Hellmuth; Rochus Franzen; Josef Pfeilschifter
The HIV protease inhibitor ritonavir synergizes with butyrate for induction of apoptotic cell death and mediates expression of heme oxygenase-1 in DLD-1 colon carcinoma cells.
British journal of pharmacology 2004;143(7):890-8.
2004: Liliana Schaefer; Shuyu Ren; Roland M Schaefer; Daniel Mihalik; Andrea Babelova; Andrea Huwiler; Josef Pfeilschifter
Nephrin expression is increased in anti-Thy1.1-induced glomerulonephritis in rats.
Biochemical and biophysical research communications 2004;324(1):247-54.
2004: Cuiyan Xin; Shuyu Ren; Josef Pfeilschifter; Andrea Huwiler
Heterologous desensitization of the sphingosine-1-phosphate receptors by purinoceptor activation in renal mesangial cells.
British journal of pharmacology 2004;143(5):581-9.
2004: Kornelija Kahlina; Itamar Goren; Josef Pfeilschifter; Stefan Frank
p68 DEAD box RNA helicase expression in keratinocytes. Regulation, nucleolar localization, and functional connection to proliferation and vascular endothelial growth factor gene expression.
The Journal of biological chemistry 2004;279(43):44872-82.
2004: Heiko Muhl; Josef Pfeilschifter
Interleukin-18 bioactivity: a novel target for immunopharmacological anti-inflammatory intervention.
European journal of pharmacology 2004;500(1-3):63-71.
2004: Cuiyan Xin; Shuyu Ren; Burkhard Kleuser; Soheyla Shabahang; Wolfgang Eberhardt; Heinfried Radeke; Monika Schäfer-Korting; Josef Pfeilschifter; Andrea Huwiler
Sphingosine 1-phosphate cross-activates the Smad signaling cascade and mimics transforming growth factor-beta-induced cell responses.
The Journal of biological chemistry 2004;279(34):35255-62.
2004: Josef Pfeilschifter; Andrea Huwiler
Erythropoietin is more than just a promoter of erythropoiesis.
Journal of the American Society of Nephrology : JASN 2004;15(8):2240-1.
2004: Markus Hellmuth; Jens Paulukat; Raiko Ninic; Josef Pfeilschifter; Heiko Muhl
Nitric oxide differentially regulates pro- and anti-angiogenic markers in DLD-1 colon carcinoma cells.
FEBS letters 2004;563(1-3):98-102.
2004: Andrea Huwiler; Cuiyan Xin; Anja-Kristina Brust; Verena A Briner; Josef Pfeilschifter
Differential binding of ceramide to MEKK1 in glomerular endothelial and mesangial cells.
Biochimica et biophysica acta 2004;1636(2-3):159-68.
2004: Claudia Nold-Petry; Gerhard Fritz; Josef Pfeilschifter; Andrea Huwiler
Inhibition of Rho modulates cytokine-induced prostaglandin E2 formation in renal mesangial cells.
Biochimica et biophysica acta 2004;1636(2-3):108-18.
2004: Prabal K Chatterjee; Nimesh S A Patel; Salvatore Cuzzocrea; Paul A J Brown; Keith N Stewart; Helder Mota-Filipe; Domenico Britti; Wolfgang Eberhardt; Josef Pfeilschifter; Christoph Thiemermann
The cyclopentenone prostaglandin 15-deoxy-Delta(12,14)-prostaglandin J2 ameliorates ischemic acute renal failure.
Cardiovascular research 2004;61(3):630-43.
2004: Cornelia Blume; Danuta Sabuda-Widemann; Josef Pfeilschifter; Jörg Plum; Karsten Schrör; Bernd Grabensee; Karl-Friedrich Beck
Cerivastatin inhibits proliferation of interleukin-1 beta-induced rat mesangial cells by enhanced formation of nitric oxide.
European journal of pharmacology 2004;485(1-3):1-10.
2004: Berthold Hocher; Anja Schwarz; Torsten Slowinski; Sebastian Bachmann; Josef Pfeilschifter; Hans-Hellmut Neumayer; Christian Bauer
In-vivo interaction of nitric oxide and endothelin.
Journal of hypertension 2004;22(1):111-9.
2004: Marietta Kaszkin; Karl-Friedrich Beck; Wolfgang Eberhardt; Josef Pfeilschifter
Unravelling green tea's mechanisms of action: more than meets the eye.
Molecular pharmacology 2004;65(1):15-7.
2003: Andrea Huwiler; El-Sayed Akool; S. Armaz Aschrafi; Farid M A Hamada; Josef Pfeilschifter; Wolfgang Eberhardt
ATP potentiates interleukin-1 beta-induced MMP-9 expression in mesangial cells via recruitment of the ELAV protein HuR.
The Journal of biological chemistry 2003;278(51):51758-69.
2003: Heiko Muhl; Sonja Höfler; Josef Pfeilschifter
Inhibition of lipopolysaccharide/ATP-induced release of interleukin-18 by KN-62 and glyburide.
European journal of pharmacology 2003;482(1-3):325-8.
2003: Thorsten Keller; Miriam Plesková; Michelle C McDonald; Christoph Thiemermann; Josef Pfeilschifter; Karl-Friedrich Beck
Identification of manganese superoxide dismutase as a NO-regulated gene in rat glomerular mesangial cells by 2D gel electrophoresis.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2003;9(4):183-93.
2003: Heiko Kämpfer; Josef Pfeilschifter; Stefan Frank
Expression and activity of arginase isoenzymes during normal and diabetes-impaired skin repair.
The Journal of investigative dermatology 2003;121(6):1544-51.
2003: Itamar Goren; Heiko Kämpfer; Maurizio Podda; Josef Pfeilschifter; Stefan Frank
Leptin and wound inflammation in diabetic ob/ob mice: differential regulation of neutrophil and macrophage influx and a potential role for the scab as a sink for inflammatory cells and mediators.
Diabetes 2003;52(11):2821-32.
2003: Stefan El-Gayar; Heike Thüring-Nahler; Josef Pfeilschifter; Martin Röllinghoff; Christian Bogdan
Translational control of inducible nitric oxide synthase by IL-13 and arginine availability in inflammatory macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(9):4561-8.
2003: Heiko Muhl; Josef Pfeilschifter
Endothelial nitric oxide synthase: a determinant of TNFalpha production by human monocytes/macrophages.
Biochemical and biophysical research communications 2003;310(3):677-80.
2003: S. Armaz Aschrafi; Rochus Franzen; Soheyla Shabahang; Doriano Fabbro; Josef Pfeilschifter; Andrea Huwiler
Ceramide induces translocation of protein kinase C-alpha to the Golgi compartment of human embryonic kidney cells by interacting with the C2 domain.
Biochimica et biophysica acta 2003;1634(1-2):30-9.
2003: Andrea Huwiler; Josef Pfeilschifter
Nitric oxide signalling with a special focus on lipid-derived mediators.
Biological chemistry 2003;384(10-11):1379-89.
2003: Heiko Muhl; Josef Pfeilschifter
Anti-inflammatory properties of pro-inflammatory interferon-gamma.
International immunopharmacology 2003;3(9):1247-55.
2003: Sabine Beck; Gérard Lambeau; Kristen Scholz-Pedretti; Michael H Gelb; Marcel J W Janssen; Suzanne H Edwards; David C Wilton; Josef Pfeilschifter; Marietta Kaszkin
Potentiation of tumor necrosis factor alpha-induced secreted phospholipase A2 (sPLA2)-IIA expression in mesangial cells by an autocrine loop involving sPLA2 and peroxisome proliferator-activated receptor alpha activation.
The Journal of biological chemistry 2003;278(32):29799-812.
2003: Marcel Nold; Ingeborg A Hauser; Sonja Höfler; Andreas Goede; Wolfgang Eberhardt; Tilmann Ditting; Helmut Geiger; Josef Pfeilschifter; Heiko Muhl
IL-18BPa:Fc cooperates with immunosuppressive drugs in human whole blood.
Biochemical pharmacology 2003;66(3):505-10.
2003: Josef Pfeilschifter; Wolfgang Eberhardt; Andrea Huwiler
Nitric oxide and mechanisms of redox signaling.
Journal of the American Society of Nephrology : JASN 2003;14(8 Suppl 3):S237-40.
2003: Maria Deja; Thilo Busch; Sebastian Bachmann; Kerstin Riskowski; Valentina Campean; Brigitte Wiedmann; Michael Schwabe; Bertold Hell; Josef Pfeilschifter; Konrad J Falke; Klaus Lewandowski
Reduced nitric oxide in sinus epithelium of patients with radiologic maxillary sinusitis and sepsis.
American journal of respiratory and critical care medicine 2003;168(3):281-6.
2003: Liliana Schaefer; Karl-Friedrich Beck; Igor Raslik; Sebastian Walpen; Daniel Mihalik; Miroslava Micegova; Katarina Reinhardt; Elke Schonherr; Daniela G Seidler; Georg Varga; Roland M Schaefer; Hans Kresse; Josef Pfeilschifter
Biglycan, a nitric oxide-regulated gene, affects adhesion, growth, and survival of mesangial cells.
The Journal of biological chemistry 2003;278(28):26227-37.
2003: Silvia Gurrieri; Gerhard Fürstenberger; Alexia Schadow; Ulrike Haas; Alan G Singer; Farideh Ghomashchi; Josef Pfeilschifter; Gérard Lambeau; Michael H Gelb; Marietta Kaszkin
Differentiation-dependent regulation of secreted phospholipases A2 in murine epidermis.
The Journal of investigative dermatology 2003;121(1):156-64.
2003: El-Sayed Akool; Hartmut Kleinert; Farid M A Hamada; Mohamed H Abdelwahab; Ulrich Förstermann; Josef Pfeilschifter; Wolfgang Eberhardt
Nitric oxide increases the decay of matrix metalloproteinase 9 mRNA by inhibiting the expression of mRNA-stabilizing factor HuR.
Molecular and cellular biology 2003;23(14):4901-16.
2003: Andrea Huwiler; Shuyu Ren; Harry Holthöfer; Hermann Pavenstädt; Josef Pfeilschifter
Inflammatory cytokines upregulate nephrin expression in human embryonic kidney epithelial cells and podocytes.
Biochemical and biophysical research communications 2003;305(1):136-42.
2003: Heiko Kämpfer; Lutz Bräutigam; Gerd Geisslinger; Josef Pfeilschifter; Stefan Frank
Cyclooxygenase-1-coupled prostaglandin biosynthesis constitutes an essential prerequisite for skin repair.
The Journal of investigative dermatology 2003;120(5):880-90.
2003: Itamar Goren; Josef Pfeilschifter; Stefan Frank
Determination of leptin signaling pathways in human and murine keratinocytes.
Biochemical and biophysical research communications 2003;303(4):1080-5.
2003: Burkhard Möller; Jens Paulukat; Marcel Nold; Meik Helmut Behrens; Natasa Kukoc-Zivojnov; Joachim Peter Kaltwasser; Josef Pfeilschifter; Heiko Muhl
Interferon-gamma induces expression of interleukin-18 binding protein in fibroblast-like synoviocytes.
Rheumatology (Oxford, England) 2003;42(3):442-5.
2003: Waltraud Rölz; Cuiyan Xin; Shuyu Ren; Josef Pfeilschifter; Andrea Huwiler
Interleukin-1beta inhibits ATP-induced protein kinase B activation in renal mesangial cells by two different mechanisms: the involvement of nitric oxide and ceramide.
British journal of pharmacology 2003;138(3):461-8.
2003: Klaus Heese; Karl-Friedrich Beck; Meik Helmut Behrens; Katharina Plüss; Wolfgang Fierlbeck; Andrea Huwiler; Heiko Muhl; Helmut Geiger; Uwe Otten; Josef Pfeilschifter
Effects of high glucose on cytokine-induced nerve growth factor (NGF) expression in rat renal mesangial cells.
Biochemical pharmacology 2003;65(2):293-301.
2003: Heiko Muhl; Josef Pfeilschifter
[A short summary. The history of glucocorticoids].
Pharmazie in unserer Zeit 2003;32(4):284-7.
2003: Marcel Nold; Andreas Goede; Wolfgang Eberhardt; Josef Pfeilschifter; Heiko Muhl
IL-18 initiates release of matrix metalloproteinase-9 from peripheral blood mononuclear cells without affecting tissue inhibitor of matrix metalloproteinases-1: suppression by TNF alpha blockage and modulation by IL-10.
Naunyn-Schmiedeberg's archives of pharmacology 2003;367(1):68-75.
2003: Daniela Bruch-Gerharz; Oliver Schnorr; Christoph V Suschek; Karl-Friedrich Beck; Josef Pfeilschifter; Thomas Ruzicka; Victoria Kolb-Bachofen
Arginase 1 overexpression in psoriasis: limitation of inducible nitric oxide synthase activity as a molecular mechanism for keratinocyte hyperproliferation.
The American journal of pathology 2003;162(1):203-11.
2003: Josef Pfeilschifter; Wolfgang Eberhardt; Karl-Friedrich Beck; Andrea Huwiler
Redox signaling in mesangial cells.
Nephron. Experimental nephrology 2003;93(1):e23-6.
2002: Rochus Franzen; Josef Pfeilschifter; Andrea Huwiler
Nitric oxide induces neutral ceramidase degradation by the ubiquitin/proteasome complex in renal mesangial cell cultures.
FEBS letters 2002;532(3):441-4.
2002: Rochus Franzen; Doriano Fabbro; S. Armaz Aschrafi; Josef Pfeilschifter; Andrea Huwiler
Nitric oxide induces degradation of the neutral ceramidase in rat renal mesangial cells and is counterregulated by protein kinase C.
The Journal of biological chemistry 2002;277(48):46184-90.
2002: Soheyla Shabahang; Yan-Hong Liu; Andrea Huwiler; Josef Pfeilschifter
Identification of the LIM kinase-1 as a ceramide-regulated gene in renal mesangial cells.
Biochemical and biophysical research communications 2002;298(3):408-13.
2002: Huige Li; Peter Junk; Andrea Huwiler; Christian Burkhardt; Thomas Wallerath; Josef Pfeilschifter; Ulrich Förstermann
Dual effect of ceramide on human endothelial cells: induction of oxidative stress and transcriptional upregulation of endothelial nitric oxide synthase.
Circulation 2002;106(17):2250-6.
2002: Wolfgang Eberhardt; El-Sayed Akool; Jorg Rebhan; Stefan Frank; Karl-Friedrich Beck; Rochus Franzen; Farid M A Hamada; Josef Pfeilschifter
Inhibition of cytokine-induced matrix metalloproteinase 9 expression by peroxisome proliferator-activated receptor alpha agonists is indirect and due to a NO-mediated reduction of mRNA stability.
The Journal of biological chemistry 2002;277(36):33518-28.
2002: Wolfgang Eberhardt; Christina Engels; Roswitha Müller; Josef Pfeilschifter
Mechanisms of dexamethasone-mediated inhibition of cAMP-induced tPA expression in rat mesangial cells.
Kidney international 2002;62(3):809-21.
2002: Markus Hellmuth; Christian Wetzler; Marcel Nold; Jae-Hyung Chang; Stefan Frank; Josef Pfeilschifter; Heiko Muhl
Expression of interleukin-8, heme oxygenase-1 and vascular endothelial growth factor in DLD-1 colon carcinoma cells exposed to pyrrolidine dithiocarbamate.
Carcinogenesis 2002;23(8):1273-9.
2002: Wolfgang Schacke; Karl-Friedrich Beck; Josef Pfeilschifter; Frank Koch; Lars-Olof Hattenbach
Modulation of tissue plasminogen activator and plasminogen activator inhibitor-1 by transforming growth factor-beta in human retinal glial cells.
Investigative ophthalmology & visual science 2002;43(8):2799-805.
2002: Wolfgang Eberhardt; Maja Schulze; Christina Engels; Elke Klasmeier; Josef Pfeilschifter
Glucocorticoid-mediated suppression of cytokine-induced matrix metalloproteinase-9 expression in rat mesangial cells: involvement of nuclear factor-kappaB and Ets transcription factors.
Molecular endocrinology (Baltimore, Md.) 2002;16(8):1752-66.
2002: Andrea Huwiler; Waltraud Rölz; Simone Dorsch; Shuyu Ren; Josef Pfeilschifter
Extracellular ATP and UTP activate the protein kinase B/Akt cascade via the P2Y(2) purinoceptor in renal mesangial cells.
British journal of pharmacology 2002;136(4):520-9.
2002: Waltraud Rölz; Cuiyan Xin; Shuyu Ren; Josef Pfeilschifter; Andrea Huwiler
Interleukin-1 inhibits angiotensin II-stimulated protein kinase B pathway in renal mesangial cells via the inducible nitric oxide synthase.
European journal of pharmacology 2002;442(3):195-203.
2002: Birgit Stallmeyer; Manuel Anhold; Christian Wetzler; Kornelija Kahlina; Josef Pfeilschifter; Stefan Frank
Regulation of eNOS in normal and diabetes-impaired skin repair: implications for tissue regeneration.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2002;6(2):168-77.
2002: Josef Pfeilschifter
Nitric oxide triggers the expression of proinflammatory and protective gene products in mesangial cells and the inflamed glomerulus.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2002;17(3):347-8.
2002: Kristen Scholz-Pedretti; Annette Gans; Karl-Friedrich Beck; Josef Pfeilschifter; Marietta Kaszkin
Potentiation of TNF-alpha-stimulated group IIA phospholipase A(2) expression by peroxisome proliferator-activated receptor alpha activators in rat mesangial cells.
Journal of the American Society of Nephrology : JASN 2002;13(3):611-20.
2002: Stefan Frank; Heiko Kämpfer; Christian Wetzler; Josef Pfeilschifter
Nitric oxide drives skin repair: novel functions of an established mediator.
Kidney international 2002;61(3):882-8.
2002: Josef Pfeilschifter; Karl-Friedrich Beck; Wolfgang Eberhardt; Andrea Huwiler
Changing gears in the course of glomerulonephritis by shifting superoxide to nitric oxide-dominated chemistry.
Kidney international 2002;61(3):809-15.
2002: Markus Manderscheid; Carmen Pereda-Fernández; Josef Pfeilschifter
Cyclic AMP increases rat inhibitor of apoptosis protein (RIAP1) mRNA in renal mesangial cells.
Kidney international 2002;61(3):797-803.
2002: Andrea Pautz; Rochus Franzen; Simone Dorsch; Boris Böddinghaus; Verena A Briner; Josef Pfeilschifter; Andrea Huwiler
Cross-talk between nitric oxide and superoxide determines ceramide formation and apoptosis in glomerular cells.
Kidney international 2002;61(3):790-6.
2002: Wolfgang Eberhardt; Karl-Friedrich Beck; Josef Pfeilschifter
Cytokine-induced expression of tPA is differentially modulated by NO and ROS in rat mesangial cells.
Kidney international 2002;61(1):20-30.
2001: G Walker; Josef Pfeilschifter; Uwe Otten; D Kunz
Proteolytic cleavage of inducible nitric oxide synthase (iNOS) by calpain I.
Biochimica et biophysica acta 2001;1568(3):216-24.
2001: Jens Paulukat; Markus Bosmann; Marcel Nold; S Garkisch; Heiko Kämpfer; Stefan Frank; Jochen Raedle; S Zeuzem; Josef Pfeilschifter; Heiko Muhl
Expression and release of IL-18 binding protein in response to IFN-gamma.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(12):7038-43.
2001: Karl-Friedrich Beck; Sebastian Walpen; Wolfgang Eberhardt; Josef Pfeilschifter
Downregulation of integrin-linked kinase mRNA expression by nitric oxide in rat glomerular mesangial cells.
Life sciences 2001;69(25-26):2945-55.
2001: Josef Pfeilschifter; W Eberhardt; Andrea Huwiler
Nitric oxide and mechanisms of redox signalling: matrix and matrix-metabolizing enzymes as prime nitric oxide targets.
European journal of pharmacology 2001;429(1-3):279-86.
2001: Irmgard Tegeder; Josef Pfeilschifter; Gerd Geisslinger
Cyclooxygenase-independent actions of cyclooxygenase inhibitors.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(12):2057-72.
2001: Rochus Franzen; Andrea Pautz; Lutz Bräutigam; Gerd Geisslinger; Josef Pfeilschifter; Andrea Huwiler
Interleukin-1beta induces chronic activation and de novo synthesis of neutral ceramidase in renal mesangial cells.
The Journal of biological chemistry 2001;276(38):35382-9.
2001: Heiko Kämpfer; N Kolb; Markus Manderscheid; Christian Wetzler; Josef Pfeilschifter; Stefan Frank
Macrophage-derived heme-oxygenase-1: expression, regulation, and possible functions in skin repair.
Molecular medicine (Cambridge, Mass.) 2001;7(7):488-98.
2001: Birgit Stallmeyer; Heiko Kämpfer; Maurizio Podda; Roland Kaufmann; Josef Pfeilschifter; Stefan Frank
A novel keratinocyte mitogen: regulation of leptin and its functional receptor in skin repair.
The Journal of investigative dermatology 2001;117(1):98-105.
2001: Andrea Huwiler; Boris Böddinghaus; Andrea Pautz; Simone Dorsch; Rochus Franzen; Verena A Briner; Volker Brade; Josef Pfeilschifter
Superoxide potently induces ceramide formation in glomerular endothelial cells.
Biochemical and biophysical research communications 2001;284(2):404-10.
2001: UK Messmer; C Pereda-Fernandez; Markus Manderscheid; Josef Pfeilschifter
Dexamethasone inhibits TNF-alpha-induced apoptosis and IAP protein downregulation in MCF-7 cells.
British journal of pharmacology 2001;133(4):467-76.
2001: Markus Manderscheid; UK Messmer; Rochus Franzen; Josef Pfeilschifter
Regulation of inhibitor of apoptosis expression by nitric oxide and cytokines: relation to apoptosis induction in rat mesangial cells and raw 264.7 macrophages.
Journal of the American Society of Nephrology : JASN 2001;12(6):1151-63.
2001: Birgit Stallmeyer; Josef Pfeilschifter; Stefan Frank
Systemically and topically supplemented leptin fails to reconstitute a normal angiogenic response during skin repair in diabetic ob/ob mice.
Diabetologia 2001;44(4):471-9.
2001: Sebastian Walpen; Karl-Friedrich Beck; Liliana Schaefer; Igor Raslik; Wolfgang Eberhardt; Roland M Schaefer; Josef Pfeilschifter
Nitric oxide induces MIP-2 transcription in rat renal mesangial cells and in a rat model of glomerulonephritis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(3):571-3.
2001: Alexia Schadow; Kristen Scholz-Pedretti; Gérard Lambeau; Michael H Gelb; Gerhard Fürstenberger; Josef Pfeilschifter; Marietta Kaszkin
Characterization of group X phospholipase A(2) as the major enzyme secreted by human keratinocytes and its regulation by the phorbol ester TPA.
The Journal of investigative dermatology 2001;116(1):31-9.
2001: Kristen Scholz-Pedretti; Josef Pfeilschifter; Marietta Kaszkin
Potentiation of cytokine induction of group IIA phospholipase A(2) in rat mesangial cells by ATP and adenosine via the A2A adenosine receptor.
British journal of pharmacology 2001;132(1):37-46.
2001: Andrea Huwiler; B Johansen; A Skarstad; Josef Pfeilschifter
Ceramide binds to the CaLB domain of cytosolic phospholipase A2 and facilitates its membrane docking and arachidonic acid release.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(1):7-9.
2000: Heiko Kämpfer; Jens Paulukat; Heiko Muhl; Christian Wetzler; Josef Pfeilschifter; Stefan Frank
Lack of interferon-gamma production despite the presence of interleukin-18 during cutaneous wound healing.
Molecular medicine (Cambridge, Mass.) 2000;6(12):1016-27.
2000: Heiko Kämpfer; Heiko Muhl; Markus Manderscheid; Uwe Kalina; D Kauschat; Josef Pfeilschifter; Stefan Frank
Regulation of interleukin-18 (IL-18) expression in keratinocytes (HaCaT): implications for early wound healing.
European cytokine network 2000;11(4):626-33.
2000: UK Messmer; Verena A Briner; Josef Pfeilschifter
Basic fibroblast growth factor selectively enhances TNF-alpha-induced apoptotic cell death in glomerular endothelial cells: effects on apoptotic signaling pathways.
Journal of the American Society of Nephrology : JASN 2000;11(12):2199-211.
2000: Heiko Muhl; Jae-Hyung Chang; Andrea Huwiler; Markus Bosmann; Jens Paulukat; R Ninic; Marcel Nold; Markus Hellmuth; Josef Pfeilschifter
Nitric oxide augments release of chemokines from monocytic U937 cells: modulation by anti-inflammatory pathways.
Free radical biology & medicine 2000;29(10):969-80.
2000: Wolfgang Eberhardt; Andrea Huwiler; Karl-Friedrich Beck; Sebastian Walpen; Josef Pfeilschifter
Amplification of IL-1 beta-induced matrix metalloproteinase-9 expression by superoxide in rat glomerular mesangial cells is mediated by increased activities of NF-kappa B and activating protein-1 and involves activation of the mitogen-activated protein kinase pathways.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(10):5788-97.
2000: UK Messmer; Josef Pfeilschifter
New insights into the mechanism for clearance of apoptotic cells.
BioEssays : news and reviews in molecular, cellular and developmental biology 2000;22(10):878-81.
2000: Christian Wetzler; Heiko Kämpfer; Josef Pfeilschifter; Stefan Frank
Keratinocyte-derived chemotactic cytokines: expressional modulation by nitric oxide in vitro and during cutaneous wound repair in vivo.
Biochemical and biophysical research communications 2000;274(3):689-96.
2000: Stefan Frank; Birgit Stallmeyer; Heiko Kämpfer; N Kolb; Josef Pfeilschifter
Leptin enhances wound re-epithelialization and constitutes a direct function of leptin in skin repair.
The Journal of clinical investigation 2000;106(4):501-9.
2000: Christian Wetzler; Heiko Kämpfer; Birgit Stallmeyer; Josef Pfeilschifter; Stefan Frank
Large and sustained induction of chemokines during impaired wound healing in the genetically diabetic mouse: prolonged persistence of neutrophils and macrophages during the late phase of repair.
The Journal of investigative dermatology 2000;115(2):245-53.
2000: Kristen Scholz-Pedretti; Wolfgang Eberhardt; G Rupprecht; Karl-Friedrich Beck; S Spitzer; Josef Pfeilschifter; Marietta Kaszkin
Inhibition of NFkappaB-mediated pro-inflammatory gene expression in rat mesangial cells by the enolized 1,3-dioxane-4, 6-dione-5-carboxamide, CGP-43182.
British journal of pharmacology 2000;130(5):1183-90.
2000: Andrea Huwiler; T Kolter; Josef Pfeilschifter; K Sandhoff
Physiology and pathophysiology of sphingolipid metabolism and signaling.
Biochimica et biophysica acta 2000;1485(2-3):63-99.
2000: UK Messmer; G Winkel; Verena A Briner; Josef Pfeilschifter
Suppression of apoptosis by glucocorticoids in glomerular endothelial cells: effects on proapoptotic pathways.
British journal of pharmacology 2000;129(8):1673-83.
2000: Stefan Frank; Heiko Kämpfer; Christian Wetzler; Birgit Stallmeyer; Josef Pfeilschifter
Large induction of the chemotactic cytokine RANTES during cutaneous wound repair: a regulatory role for nitric oxide in keratinocyte-derived RANTES expression.
The Biochemical journal 2000;347 Pt 1():265-73.
2000: Stefan Frank; Heiko Kämpfer; Maurizio Podda; R Kaufmann; Josef Pfeilschifter
Identification of copper/zinc superoxide dismutase as a nitric oxide-regulated gene in human (HaCaT) keratinocytes: implications for keratinocyte proliferation.
The Biochemical journal 2000;346 Pt 3():719-28.
2000: Sebastian Walpen; Karl-Friedrich Beck; Wolfgang Eberhardt; M Apel; P K Chatterjee; G M Wray; Christoph Thiemermann; Josef Pfeilschifter
Downregulation of SPARC expression is mediated by nitric oxide in rat mesangial cells and during endotoxemia in the rat.
Journal of the American Society of Nephrology : JASN 2000;11(3):468-76.
2000: Andrea Huwiler; M Wartmann; H van den Bosch; Josef Pfeilschifter
Extracellular nucleotides activate the p38-stress-activated protein kinase cascade in glomerular mesangial cells.
British journal of pharmacology 2000;129(3):612-8.
2000: Heiko Muhl; Heiko Kämpfer; Markus Bosmann; Stefan Frank; Heinfried Radeke; Josef Pfeilschifter
Interferon-gamma mediates gene expression of IL-18 binding protein in nonleukocytic cells.
Biochemical and biophysical research communications 2000;267(3):960-3.
2000: Josef Pfeilschifter
Signalling pathways of nitric oxide.
Kidney & blood pressure research 2000;23(3-5):159-61.
2000: Wolfgang Eberhardt; Thomas Beeg; Karl-Friedrich Beck; Sebastian Walpen; Stefan Gauer; Hansjosef Böhles; Josef Pfeilschifter
Nitric oxide modulates expression of matrix metalloproteinase-9 in rat mesangial cells.
Kidney international 2000;57(1):59-69.
1999: Birgit Stallmeyer; Heiko Kämpfer; N Kolb; Josef Pfeilschifter; Stefan Frank
The function of nitric oxide in wound repair: inhibition of inducible nitric oxide-synthase severely impairs wound reepithelialization.
The Journal of investigative dermatology 1999;113(6):1090-8.
1999: K Scholz; G J Vlachojannis; S Spitzer; Valérie B Schini-Kerth; H van den Bosch; Marietta Kaszkin; Josef Pfeilschifter
Modulation of cytokine-induced expression of secretory phospholipase A2-type IIA by protein kinase C in rat renal mesangial cells.
Biochemical pharmacology 1999;58(11):1751-8.
1999: Stefan Frank; Birgit Stallmeyer; Heiko Kämpfer; N Kolb; Josef Pfeilschifter
Nitric oxide triggers enhanced induction of vascular endothelial growth factor expression in cultured keratinocytes (HaCaT) and during cutaneous wound repair.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(14):2002-14.
1999: Heiko Muhl; Marcel Nold; Jae-Hyung Chang; Stefan Frank; Wolfgang Eberhardt; Josef Pfeilschifter
Expression and release of chemokines associated with apoptotic cell death in human promonocytic U937 cells and peripheral blood mononuclear cells.
European journal of immunology 1999;29(10):3225-35.
1999: Heiko Kämpfer; Uwe Kalina; Heiko Muhl; Josef Pfeilschifter; Stefan Frank
Counterregulation of interleukin-18 mRNA and protein expression during cutaneous wound repair in mice.
The Journal of investigative dermatology 1999;113(3):369-74.
1999: UK Messmer; G Winkel; Verena A Briner; Josef Pfeilschifter
Glucocorticoids potently block tumour necrosis factor-alpha- and lipopolysaccharide-induced apoptotic cell death in bovine glomerular endothelial cells upstream of caspase 3 activation.
British journal of pharmacology 1999;127(7):1633-40.
1999: Josef Pfeilschifter; Heiko Muhl
Immunopharmacology: anti-inflammatory therapy targeting transcription factors.
European journal of pharmacology 1999;375(1-3):237-45.
1999: UK Messmer; Verena A Briner; Josef Pfeilschifter
Tumor necrosis factor-alpha and lipopolysaccharide induce apoptotic cell death in bovine glomerular endothelial cells.
Kidney international 1999;55(6):2322-37.
1999: G Rupprecht; K Scholz; Karl-Friedrich Beck; Helmut Geiger; Josef Pfeilschifter; Marietta Kaszkin
Cross-talk between group IIA-phospholipase A2 and inducible NO-synthase in rat renal mesangial cells.
British journal of pharmacology 1999;127(1):51-6.
1999: Stefan Frank; Kai Zacharowski; G M Wray; Christoph Thiemermann; Josef Pfeilschifter
Identification of copper/zinc superoxide dismutase as a novel nitric oxide-regulated gene in rat glomerular mesangial cells and kidneys of endotoxemic rats.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(8):869-82.
1999: Andrea Huwiler; Simone Dorsch; Verena A Briner; H van den Bosch; Josef Pfeilschifter
Nitric oxide stimulates chronic ceramide formation in glomerular endothelial cells.
Biochemical and biophysical research communications 1999;258(1):60-5.
1999: Andrea Huwiler; Josef Pfeilschifter; H van den Bosch
Nitric oxide donors induce stress signaling via ceramide formation in rat renal mesangial cells.
The Journal of biological chemistry 1999;274(11):7190-5.
1999: Stefan Frank; Birgit Stallmeyer; Heiko Kämpfer; C Schaffner; Josef Pfeilschifter
Differential regulation of vascular endothelial growth factor and its receptor fms-like-tyrosine kinase is mediated by nitric oxide in rat renal mesangial cells.
The Biochemical journal 1999;338 ( Pt 2)():367-74.
1999: Andrea Huwiler; Josef Pfeilschifter
Nitric oxide stimulates the stress-activated protein kinase p38 in rat renal mesangial cells.
The Journal of experimental biology 1999;202(Pt 6):655-60.
1999: Karl-Friedrich Beck; Wolfgang Eberhardt; Stefan Frank; Andrea Huwiler; UK Messmer; Heiko Muhl; Josef Pfeilschifter
Inducible NO synthase: role in cellular signalling.
The Journal of experimental biology 1999;202(Pt 6):645-53.
1998: Stefan Frank; N Kolb; Ernst R Werner; Josef Pfeilschifter
Coordinated induction of inducible nitric oxide synthase and GTP-cyclohydrolase I is dependent on inflammatory cytokines and interferon-gamma in HaCaT keratinocytes: implications for the model of cutaneous wound repair.
The Journal of investigative dermatology 1998;111(6):1065-71.
1998: Stefan Frank; M Madlener; Josef Pfeilschifter; S Werner
Induction of inducible nitric oxide synthase and its corresponding tetrahydrobiopterin-cofactor-synthesizing enzyme GTP-cyclohydrolase I during cutaneous wound repair.
The Journal of investigative dermatology 1998;111(6):1058-64.
1998: Ellen I Closs; F Enseleit; D Koesling; Josef Pfeilschifter; Petra M Schwarz; Ulrich Förstermann
Coexpression of inducible NO synthase and soluble guanylyl cyclase in colonic enterocytes: a pathophysiologic signaling pathway for the initiation of diarrhea by gram-negative bacteria?
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1998;12(15):1643-9.
1998: Marietta Kaszkin; Andrea Huwiler; K Scholz; H van den Bosch; Josef Pfeilschifter
Negative regulation of interleukin-1beta-activated neutral sphingomyelinase by protein kinase C in rat mesangial cells.
FEBS letters 1998;440(1-2):163-6.
1998: D Callsen; Josef Pfeilschifter; Bernhard Brüne
Rapid and delayed p42/p44 mitogen-activated protein kinase activation by nitric oxide: the role of cyclic GMP and tyrosine phosphatase inhibition.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(9):4852-8.
1998: C Lapize; C Plüss; Ernst R Werner; Andrea Huwiler; Josef Pfeilschifter
Protein kinase C phosphorylates and activates GTP cyclohydrolase I in rat renal mesangial cells.
Biochemical and biophysical research communications 1998;251(3):802-5.
1998: Andrea Huwiler; Doriano Fabbro; Josef Pfeilschifter
Selective ceramide binding to protein kinase C-alpha and -delta isoenzymes in renal mesangial cells.
Biochemistry 1998;37(41):14556-62.
1998: Karl-Friedrich Beck; Wolfgang Eberhardt; Sebastian Walpen; M Apel; Josef Pfeilschifter
Potentiation of nitric oxide synthase expression by superoxide in interleukin 1 beta-stimulated rat mesangial cells.
FEBS letters 1998;435(1):35-8.
1998: Josef Pfeilschifter; Andrea Huwiler
Identification of ceramide targets in interleukin-1 and tumor necrosis factor-alpha signaling in mesangial cells.
Kidney international. Supplement 1998;67():S34-9.
1998: Michel O Steinmetz; C Plüss; Urs Christen; B Wolpensinger; Ariel Lustig; Ernst R Werner; H Wachter; Andreas Engel; Ueli Aebi; Josef Pfeilschifter; Richard A Kammerer
Rat GTP cyclohydrolase I is a homodecameric protein complex containing high-affinity calcium-binding sites.
Journal of molecular biology 1998;279(1):189-99.
1998: Wolfgang Eberhardt; C Plüss; R Hummel; Josef Pfeilschifter
Molecular mechanisms of inducible nitric oxide synthase gene expression by IL-1beta and cAMP in rat mesangial cells.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(10):4961-9.
1998: G Walker; D Kunz; W Pignat; Josef Pfeilschifter
Platelet-derived growth factor and fibroblast growth factor differentially regulate interleukin 1beta- and cAMP-induced group II phospholipase A2 expression in rat renal mesangial cells.
Biochimica et biophysica acta 1998;1391(2):213-22.
1998: Andrea Huwiler; Gerda S A T van Rossum; M Wartmann; Josef Pfeilschifter
Angiotensin II stimulation of the stress-activated protein kinases in renal mesangial cells is mediated by the angiotensin AT1 receptor subtype.
European journal of pharmacology 1998;343(2-3):297-302.
1998: KB Sandau; Josef Pfeilschifter; Bernhard Brüne
Nitrosative and oxidative stress induced heme oxygenase-1 accumulation in rat mesangial cells.
European journal of pharmacology 1998;342(1):77-84.
1997: D Kunz; G Walker; Wolfgang Eberhardt; UK Messmer; Andrea Huwiler; Josef Pfeilschifter
Platelet-derived growth factor and fibroblast growth factor differentially regulate interleukin 1beta- and cAMP-induced nitric oxide synthase expression in rat renal mesangial cells.
The Journal of clinical investigation 1997;100(11):2800-9.
1997: Andrea Huwiler; G Staudt; R M Kramer; Josef Pfeilschifter
Cross-talk between secretory phospholipase A2 and cytosolic phospholipase A2 in rat renal mesangial cells.
Biochimica et biophysica acta 1997;1348(3):257-72.
1997: C Plüss; Ernst R Werner; H Wachter; Josef Pfeilschifter
Differential effect of dexamethasone on interleukin 1beta- and cyclic AMP-triggered expression of GTP cyclohydrolase I in rat renal mesangial cells.
British journal of pharmacology 1997;122(3):534-8.
1997: D Kunz; G Walker; Josef Pfeilschifter
Transforming growth factor-beta 2 inhibits interleukin 1 beta-induced expression of inducible nitric oxide synthase in rat renal mesangial cells.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 1997;46(9):327-31.
1997: KB Sandau; Josef Pfeilschifter; Bernhard Brüne
Nitric oxide and superoxide induced p53 and Bax accumulation during mesangial cell apoptosis.
Kidney international 1997;52(2):378-86.
1997: Andrea Huwiler; Verena A Briner; D Fabbro; Josef Pfeilschifter
Feedback regulation of extracellular ATP-stimulated phosphoinositide hydrolysis by protein kinase C-alpha in bovine glomerular endothelial cells.
Kidney international 1997;52(2):329-37.
1997: G Walker; Josef Pfeilschifter; D Kunz
Mechanisms of suppression of inducible nitric-oxide synthase (iNOS) expression in interferon (IFN)-gamma-stimulated RAW 264.7 cells by dexamethasone. Evidence for glucocorticoid-induced degradation of iNOS protein by calpain as a key step in post-transcriptional regulation.
The Journal of biological chemistry 1997;272(26):16679-87.
1997: G Walker; D Kunz; W Pignat; H van den Bosch; Josef Pfeilschifter
Suppression by cyclosporin A of interleukin 1 beta-induced expression of group II phospholipase A2 in rat renal mesangial cells.
British journal of pharmacology 1997;121(4):787-93.
1997: KB Sandau; Josef Pfeilschifter; Bernhard Brüne
The balance between nitric oxide and superoxide determines apoptotic and necrotic death of rat mesangial cells.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(10):4938-46.
1997: Josef Pfeilschifter; Andrea Huwiler
Phospholipase A2 in mesangial cells: control mechanisms and functional importance.
Experimental nephrology 1997;5(3):189-93.
1997: D Geiges; Thomas Meyer; B Marte; M Vanek; G Weissgerber; S Stabel; Josef Pfeilschifter; D Fabbro; Andrea Huwiler
Activation of protein kinase C subtypes alpha, gamma, delta, epsilon, zeta, and eta by tumor-promoting and nontumor-promoting agents.
Biochemical pharmacology 1997;53(6):865-75.
1997: Andrea Huwiler; Gerda S A T van Rossum; M Wartmann; Josef Pfeilschifter
Stimulation by extracellular ATP and UTP of the stress-activated protein kinase cascade in rat renal mesangial cells.
British journal of pharmacology 1997;120(5):807-12.
1997: D D Nitsch; Nico Ghilardi; Heiko Muhl; Cordula Nitsch; B Brüne; Josef Pfeilschifter
Apoptosis and expression of inducible nitric oxide synthase are mutually exclusive in renal mesangial cells.
The American journal of pathology 1997;150(3):889-900.
1996: Heiko Muhl; KB Sandau; Bernhard Brüne; Verena A Briner; Josef Pfeilschifter
Nitric oxide donors induce apoptosis in glomerular mesangial cells, epithelial cells and endothelial cells.
European journal of pharmacology 1996;317(1):137-49.
1996: Josef Pfeilschifter; Andrea Huwiler
Regulatory functions of protein kinase C isoenzymes in purinoceptor signalling in mesangial cells.
Journal of autonomic pharmacology 1996;16(6):315-8.
1996: Josef Pfeilschifter; Andrea Huwiler
Nitric oxide stimulates stress-activated protein kinases in glomerular endothelial and mesangial cells.
FEBS letters 1996;396(1):67-70.
1996: C Plüss; Ernst R Werner; N Blau; H Wachter; Josef Pfeilschifter
Interleukin 1 beta and cAMP trigger the expression of GTP cyclohydrolase I in rat renal mesangial cells.
The Biochemical journal 1996;318 ( Pt 2)():665-71.
1996: D Kunz; G Walker; I Wiesenberg; Josef Pfeilschifter
Inhibition by tetranactin of interleukin 1 beta- and cyclic AMP-induced nitric oxide synthase expression in rat renal mesangial cells.
British journal of pharmacology 1996;118(7):1621-6.
1996: Andrea Huwiler; J Brunner; R Hummel; M Vervoordeldonk; S Stabel; H van den Bosch; Josef Pfeilschifter
Ceramide-binding and activation defines protein kinase c-Raf as a ceramide-activated protein kinase.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(14):6959-63.
1996: Wolfgang Eberhardt; D Kunz; R Hummel; Josef Pfeilschifter
Molecular cloning of the rat inducible nitric oxide synthase gene promoter.
Biochemical and biophysical research communications 1996;223(3):752-6.
1996: G Walker; D Kunz; W Pignat; I Wiesenberg; H Van den Bosch; Josef Pfeilschifter
Tetranactin inhibits interleukin 1 beta and cAMP induction of group II phospholipase A2 in rat renal mesangial cells.
European journal of pharmacology 1996;306(1-3):265-70.
1996: M J Vervoordeldonk; C G Schalkwijk; Josef Pfeilschifter; H van den Bosch
Effects of dexamethasone and transforming growth factor-beta 2 on group II phospholipase A2 mRNA and activity levels in interleukin 1 beta- and forskolin-stimulated mesangial cells.
The Biochemical journal 1996;315 ( Pt 2)():435-41.
1996: Heiko Muhl; D Nitsch; KB Sandau; Bernhard Brüne; Z Varga; Josef Pfeilschifter
Apoptosis is triggered by the cyclic AMP signalling pathway in renal mesangial cells.
FEBS letters 1996;382(3):271-5.
1996: D Kunz; G Walker; Wolfgang Eberhardt; Josef Pfeilschifter
Molecular mechanisms of dexamethasone inhibition of nitric oxide synthase expression in interleukin 1 beta-stimulated mesangial cells: evidence for the involvement of transcriptional and posttranscriptional regulation.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(1):255-9.
1996: Josef Pfeilschifter; Wolfgang Eberhardt; R Hummel; D Kunz; Heiko Muhl; D Nitsch; C Plüss; G Walker
Therapeutic strategies for the inhibition of inducible nitric oxide synthase--potential for a novel class of anti-inflammatory agents.
Cell biology international 1996;20(1):51-8.
1996: Heiko Muhl; Josef Pfeilschifter
Amplification of nitric oxide synthase expression by nitric oxide in interleukin 1beta-stimulated rat mesangial cells.
Advances in experimental medicine and biology 1996;387():199-202.
1995: K M Plüss; Josef Pfeilschifter; Heiko Muhl; Andrea Huwiler; C Boeckh; Uwe Otten
Modulatory role of platelet-derived growth factor on cytokine-induced nerve growth factor synthesis in rat glomerular mesangial cells.
The Biochemical journal 1995;312 ( Pt 3)():707-11.
1995: D Kunz; G Walker; Wolfgang Eberhardt; D Nitsch; Josef Pfeilschifter
Interleukin 1 beta-induced expression of nitric oxide synthase in rat renal mesangial cells is suppressed by cyclosporin A.
Biochemical and biophysical research communications 1995;216(2):438-46.
1995: Josef Pfeilschifter
Does nitric oxide, an inflammatory mediator of glomerular mesangial cells, have a role in diabetic nephropathy?
Kidney international. Supplement 1995;51():S50-60.
1995: G Walker; D Kunz; W Pignat; H van den Bosch; Josef Pfeilschifter
Pyrrolidine dithiocarbamate differentially affects cytokine- and cAMP-induced expression of group II phospholipase A2 in rat renal mesangial cells.
FEBS letters 1995;364(2):218-22.
1995: Heiko Muhl; Josef Pfeilschifter
Amplification of nitric oxide synthase expression by nitric oxide in interleukin 1 beta-stimulated rat mesangial cells.
The Journal of clinical investigation 1995;95(4):1941-6.
1995: Andrea Huwiler; S Stabel; D Fabbro; Josef Pfeilschifter
Platelet-derived growth factor and angiotensin II stimulate the mitogen-activated protein kinase cascade in renal mesangial cells: comparison of hypertrophic and hyperplastic agonists.
The Biochemical journal 1995;305 ( Pt 3)():777-84.
1995: Andrea Huwiler; D Fabbro; Josef Pfeilschifter
Platelet-derived growth factor stimulates de-novo synthesis of mitogen-activated protein kinase in renal mesangial cells.
European journal of biochemistry / FEBS 1995;227(1-2):209-13.
1995: Josef Pfeilschifter; Andrea Huwiler; Verena A Briner
Proliferative mechanisms in kidney cells.
Current opinion in nephrology and hypertension 1995;4(1):98-103.
1994: Andrea Huwiler; Josef Pfeilschifter
Stimulation by extracellular ATP and UTP of the mitogen-activated protein kinase cascade and proliferation of rat renal mesangial cells.
British journal of pharmacology 1994;113(4):1455-63.
1994: D Kunz; G Walker; Josef Pfeilschifter
Dexamethasone differentially affects interleukin 1 beta- and cyclic AMP-induced nitric oxide synthase mRNA expression in renal mesangial cells.
The Biochemical journal 1994;304 ( Pt 2)():337-40.
1994: Andrea Huwiler; Josef Pfeilschifter
Transforming growth factor beta 2 stimulates acute and chronic activation of the mitogen-activated protein kinase cascade in rat renal mesangial cells.
FEBS letters 1994;354(3):255-8.
1994: Heiko Muhl; Josef Pfeilschifter
Tetrahydrobiopterin is a limiting factor of nitric oxide generation in interleukin 1 beta-stimulated rat glomerular mesangial cells.
Kidney international 1994;46(5):1302-6.
1994: Heiko Muhl; Josef Pfeilschifter
Possible role of protein kinase C-epsilon isoenzyme in inhibition of interleukin 1 beta induction of nitric oxide synthase in rat renal mesangial cells.
The Biochemical journal 1994;303 ( Pt 2)():607-12.
1994: Andrea Huwiler; D Fabbro; Josef Pfeilschifter
Comparison of different tumour promoters and bryostatin 1 on protein kinase C activation and down-regulation in rat renal mesangial cells.
Biochemical pharmacology 1994;48(4):689-700.
1994: Andrea Huwiler; Josef Pfeilschifter
Interleukin-1 stimulates de novo synthesis of mitogen-activated protein kinase in glomerular mesangial cells.
FEBS letters 1994;350(1):135-8.
1994: D Kunz; Heiko Muhl; G Walker; Josef Pfeilschifter
Two distinct signaling pathways trigger the expression of inducible nitric oxide synthase in rat renal mesangial cells.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(12):5387-91.
1994: Heiko Muhl; D Kunz; Josef Pfeilschifter
Expression of nitric oxide synthase in rat glomerular mesangial cells mediated by cyclic AMP.
British journal of pharmacology 1994;112(1):1-8.
1994: Wolfgang Eberhardt; D Kunz; Josef Pfeilschifter
Pyrrolidine dithiocarbamate differentially affects interleukin 1 beta- and cAMP-induced nitric oxide synthase expression in rat renal mesangial cells.
Biochemical and biophysical research communications 1994;200(1):163-70.
1994: Josef Pfeilschifter; D Kunz; Heiko Muhl; Wolfgang Eberhardt
Cytokine regulation of nitric oxide synthase expression in glomerular mesangial cells.
Experimental nephrology 1994;2(2):145.
1993: Heiko Muhl; D Kunz; P Rob; Josef Pfeilschifter
Cyclosporin derivatives inhibit interleukin 1 beta induction of nitric oxide synthase in renal mesangial cells.
European journal of pharmacology 1993;249(1):95-100.
1993: Josef Pfeilschifter; C Schalkwijk; Verena A Briner; H van den Bosch
Cytokine-stimulated secretion of group II phospholipase A2 by rat mesangial cells. Its contribution to arachidonic acid release and prostaglandin synthesis by cultured rat glomerular cells.
The Journal of clinical investigation 1993;92(5):2516-23.
1993: C G Schalkwijk; M Vervoordeldonk; Josef Pfeilschifter; H van den Bosch
Interleukin-1 beta-induced cytosolic phospholipase A2 activity and protein synthesis is blocked by dexamethasone in rat mesangial cells.
FEBS letters 1993;333(3):339-43.
1993: Josef Pfeilschifter; Andrea Huwiler
A role for protein kinase C-epsilon in angiotensin II stimulation of phospholipase D in rat renal mesangial cells.
FEBS letters 1993;331(3):267-71.
1993: Josef Pfeilschifter; C Merriweather
Extracellular ATP and UTP activation of phospholipase D is mediated by protein kinase C-epsilon in rat renal mesangial cells.
British journal of pharmacology 1993;110(2):847-53.
1993: Andrea Huwiler; Josef Pfeilschifter
A role for protein kinase C-alpha in zymosan-stimulated eicosanoid synthesis in mouse peritoneal macrophages.
European journal of biochemistry / FEBS 1993;217(1):69-75.
1993: Josef Pfeilschifter; Heiko Muhl; W Pignat; F Märki; H van den Bosch
Cytokine regulation of group II phospholipase A2 expression in glomerular mesangial cells.
European journal of clinical pharmacology 1993;44 Suppl 1():S7-9.
1993: Josef Pfeilschifter; D Kunz; Heiko Muhl
Nitric oxide: an inflammatory mediator of glomerular mesangial cells.
Nephron 1993;64(4):518-25.
1992: C G Schalkwijk; EC de Vet; Josef Pfeilschifter; H van den Bosch
Interleukin-1 beta and transforming growth factor-beta 2 enhance cytosolic high-molecular-mass phospholipase A2 activity and induce prostaglandin E2 formation in rat mesangial cells.
European journal of biochemistry / FEBS 1992;210(1):169-76.
1992: C Schalkwijk; Josef Pfeilschifter; F Märki; H van den Bosch
Interleukin-1 beta- and forskolin-induced synthesis and secretion of group II phospholipase A2 and prostaglandin E2 in rat mesangial cells is prevented by transforming growth factor-beta 2.
The Journal of biological chemistry 1992;267(13):8846-51.
1992: Heiko Muhl; T Geiger; W Pignat; F Märki; H van den Bosch; N Cerletti; D Cox; G McMaster; Klaus Dieter Vosbeck; Josef Pfeilschifter
Transforming growth factors type-beta and dexamethasone attenuate group II phospholipase A2 gene expression by interleukin-1 and forskolin in rat mesangial cells.
FEBS letters 1992;301(2):190-4.
1992: Andrea Huwiler; D Fabbro; S Stabel; Josef Pfeilschifter
Immunocharacterization of delta- and zeta-isoenzymes of protein kinase C in rat renal mesangial cells.
FEBS letters 1992;300(3):259-62.
1992: Josef Pfeilschifter; Andrea Huwiler; C Merriweather; Verena A Briner
Angiotensin II stimulation of phospholipase D in rat renal mesangial cells is mediated by the AT1 receptor subtype.
European journal of pharmacology 1992;225(1):57-62.
1992: H van den Bosch; C Schalkwijk; Josef Pfeilschifter; F Märki
The induction of cellular group II phospholipase A2 by cytokines and its prevention by dexamethasone.
Advances in experimental medicine and biology 1992;318():1-10.
1991: Josef Pfeilschifter
Platelet-derived growth factor inhibits cytokine induction of nitric oxide synthase in rat renal mesangial cells.
European journal of pharmacology 1991;208(4):339-40.
1991: P Steiner; Josef Pfeilschifter; C Boeckh; Heinfried Radeke; Uwe Otten
Interleukin-1 beta and tumor necrosis factor-alpha synergistically stimulate nerve growth factor synthesis in rat mesangial cells.
The American journal of physiology 1991;261(5 Pt 2):F792-8.
1991: Heiko Muhl; T Geiger; W Pignat; F Märki; H van den Bosch; Klaus Dieter Vosbeck; Josef Pfeilschifter
PDGF suppresses the activation of group II phospholipase A2 gene expression by interleukin 1 and forskolin in mesangial cells.
FEBS letters 1991;291(2):249-52.
1991: C Schalkwijk; M Vervoordeldonk; Josef Pfeilschifter; F Märki; H van den Bosch
Cytokine- and forskolin-induced synthesis of group II phospholipase A2 and prostaglandin E2 in rat mesangial cells is prevented by dexamethasone.
Biochemical and biophysical research communications 1991;180(1):46-52.
1991: Andrea Huwiler; D Fabbro; Josef Pfeilschifter
Possible regulatory functions of protein kinase C-alpha and -epsilon isoenzymes in rat renal mesangial cells. Stimulation of prostaglandin synthesis and feedback inhibition of angiotensin II-stimulated phosphoinositide hydrolysis.
The Biochemical journal 1991;279 ( Pt 2)():441-5.
1991: I Wiesenberg-Boettcher; Josef Pfeilschifter; A Schweizer; A Sallmann; P Wenk
Pharmacological properties of five diclofenac metabolites identified in human plasma.
Agents and actions 1991;34(1-2):135-7.
1991: C Schalkwijk; Josef Pfeilschifter; F Märki; H van den Bosch
Interleukin-1 beta, tumor necrosis factor and forskolin stimulate the synthesis and secretion of group II phospholipase A2 in rat mesangial cells.
Biochemical and biophysical research communications 1991;174(1):268-75.
1991: Josef Pfeilschifter; J Leighton; W Pignat; F Märki; Klaus Dieter Vosbeck
Cyclic AMP mimics, but does not mediate, interleukin-1- and tumour-necrosis-factor-stimulated phospholipase A2 secretion from rat renal mesangial cells.
The Biochemical journal 1991;273(Pt 1)():199-204.
1991: Josef Pfeilschifter; M Hosang
Effects of homo- and heterodimeric isoforms of PDGF on signalling events in rat renal mesangial cells.
Cellular signalling 1991;3(5):413-24.
1990: Josef Pfeilschifter
Comparison of extracellular ATP and UTP signalling in rat renal mesangial cells. No indications for the involvement of separate purino- and pyrimidino-ceptors.
The Biochemical journal 1990;272(2):469-72.
1990: Josef Pfeilschifter; W Pignat; J Leighton; F Märki; Klaus Dieter Vosbeck; S Alkan
Transforming growth factor beta 2 differentially modulates interleukin-1 beta- and tumour-necrosis-factor-alpha-stimulated phospholipase A2 and prostaglandin E2 synthesis in rat renal mesangial cells.
The Biochemical journal 1990;270(1):269-71.
1990: Josef Pfeilschifter
Angiotensin II B-type receptor mediates phosphoinositide hydrolysis in mesangial cells.
European journal of pharmacology 1990;184(1):201-2.
1990: Josef Pfeilschifter; Heiko Muhl
Interleukin 1 and tumor necrosis factor potentiate angiotensin II- and calcium ionophore-stimulated prostaglandin E2 synthesis in rat renal mesangial cells.
Biochemical and biophysical research communications 1990;169(2):585-95.
1990: F Märki; Josef Pfeilschifter; H Rink; I Wiesenberg
'Antiflammins': two nonapeptide fragments of uteroglobin and lipocortin I have no phospholipase A2-inhibitory and anti-inflammatory activity.
FEBS letters 1990;264(2):171-5.
1989: Josef Pfeilschifter; W Pignat; F Märki; I Wiesenberg
Release of phospholipase A2 activity from rat vascular smooth muscle cells mediated by cAMP.
European journal of biochemistry / FEBS 1989;181(1):237-42.
1989: Josef Pfeilschifter; W Pignat; K Vosbeck; F Märki
Interleukin 1 and tumor necrosis factor synergistically stimulate prostaglandin synthesis and phospholipase A2 release from rat renal mesangial cells.
Biochemical and biophysical research communications 1989;159(2):385-94.
1989: I Wiesenberg-Boettcher; A Schweizer; J R Green; K Mueller; F Maerki; Josef Pfeilschifter
The pharmacological profile of CGP 28238, a novel highly potent anti-inflammatory compound.
Drugs under experimental and clinical research 1989;15(11-12):501-9.