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Josef Pfeilschifter

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
84
Huwiler, Andrea
59
Muhl, Heiko
47
Eberhardt, Wolfgang
38
Frank, Stefan
25
Beck, Karl-Friedrich
20
Kämpfer, Heiko
20
Kunz, D
15
Kaszkin, Marietta
14
Walker, G
13
Ren, Shuyu
13
Briner, Verena
12
Akool, El-Sayed
11
Goren, Itamar
11
Xin, Cuiyan
10
Doller, Anke

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Publications

TOP 3
Osman Bashier; Doller Anke; Akool El-Sayed; Holdener Martin; Hintermann Edith; Pfeilschifter Josef; Eberhardt Wolfgang
Rapamycin induces the TGFbeta1/Smad signaling cascade in renal mesangial cells upstream of mTOR.
Balah Amany; Akool El-Sayed; Bachmann Malte; Pfeilschifter Josef; Mühl Heiko
The dsRNA-mimetic poly (I:C) and IL-18 synergize for IFNgamma and TNFalpha expression.
Czech Bozena; Pfeilschifter Waltraud; Mazaheri-Omrani Niloufar; Strobel Marc André; Kahles Timo; Neumann-Haefelin Tobias; Rami Abdelhaq; Huwiler Andrea; Pfeilschifter Josef
The immunomodulatory sphingosine 1-phosphate analog FTY720 reduces lesion size and improves neurological outcome in a mouse model of cerebral ischemia.

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All Publications

2009: Osman Bashier; Doller Anke; Akool El-Sayed; Holdener Martin; Hintermann Edith; Pfeilschifter Josef; Eberhardt Wolfgang
Rapamycin induces the TGFbeta1/Smad signaling cascade in renal mesangial cells upstream of mTOR.
Cellular signalling 2009;21(12):1806-17.
2009: Balah Amany; Akool El-Sayed; Bachmann Malte; Pfeilschifter Josef; Mühl Heiko
The dsRNA-mimetic poly (I:C) and IL-18 synergize for IFNgamma and TNFalpha expression.
Biochemical and biophysical research communications 2009;389(4):628-33.
2009: Czech Bozena; Pfeilschifter Waltraud; Mazaheri-Omrani Niloufar; Strobel Marc André; Kahles Timo; Neumann-Haefelin Tobias; Rami Abdelhaq; Huwiler Andrea; Pfeilschifter Josef
The immunomodulatory sphingosine 1-phosphate analog FTY720 reduces lesion size and improves neurological outcome in a mouse model of cerebral ischemia.
Biochemical and biophysical research communications 2009;389(2):251-6.
2009: Ren Shuyu; Babelova Andrea; Moreth Kristin; Xin Cuiyan; Eberhardt Wolfgang; Doller Anke; Pavenstädt Hermann; Schaefer Liliana; Pfeilschifter Josef; Huwiler Andrea
Transforming growth factor-beta2 upregulates sphingosine kinase-1 activity, which in turn attenuates the fibrotic response to TGF-beta2 by impeding CTGF expression.
Kidney international 2009;76(8):857-67.
2009: Huwiler Andrea; Pfeilschifter Josef
Lipids as targets for novel anti-inflammatory therapies.
Pharmacology & therapeutics 2009;124(1):96-112.
2009: Babelova Andrea; Moreth Kristin; Tsalastra-Greul Wasiliki; Zeng-Brouwers Jinyang; Eickelberg Oliver; Young Marian F; Bruckner Peter; Pfeilschifter Josef; Schaefer Roland M; Gröne Hermann-Josef; Schaefer Liliana
Biglycan, a danger signal that activates the NLRP3 inflammasome via toll-like and P2X receptors.
The Journal of biological chemistry 2009;284(36):24035-48.
2009: Dreieicher Ellen; Beck Karl-Friedrich; Lazaroski Sandra; Boosen Meike; Tsalastra-Greul Wasiliki; Beck Martina; Fleming Ingrid; Schaefer Liliana; Pfeilschifter Josef
Nitric oxide inhibits glomerular TGF-beta signaling via SMOC-1.
Journal of the American Society of Nephrology : JASN 2009;20(9):1963-74.
2009: Sadik Christian D; Bachmann Malte; Pfeilschifter Josef; Mühl Heiko
Activation of interferon regulatory factor-3 via toll-like receptor 3 and immunomodulatory functions detected in A549 lung epithelial cells exposed to misplaced U1-snRNA.
Nucleic acids research 2009;37(15):5041-56.
2009: Pushparaj Peter N; Manikandan Jayapal; Tay Hwee Kee; H'ng Shiau Chen; Kumar Srinivasan D; Pfeilschifter Josef; Huwiler Andrea; Melendez Alirio J
Sphingosine kinase 1 is pivotal for Fc epsilon RI-mediated mast cell signaling and functional responses in vitro and in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(1):221-7.
2009: Goren Itamar; Allmann Nadine; Yogev Nir; Schürmann Christoph; Linke Andreas; Holdener Martin; Waisman Ari; Pfeilschifter Josef; Frank Stefan
A transgenic mouse model of inducible macrophage depletion: effects of diphtheria toxin-driven lysozyme M-specific cell lineage ablation on wound inflammatory, angiogenic, and contractive processes.
The American journal of pathology 2009;175(1):132-47.
2009: Gutwein Paul; Abdel-Bakky Mohamed Sadek; Schramme Anja; Doberstein Kai; Kämpfer-Kolb Nicole; Amann Kerstin; Hauser Ingeborg A; Obermüller Nicholas; Bartel Christine; Abdel-Aziz Abdel-Aziz H; El Sayed El Sayed M; Pfeilschifter Josef
CXCL16 is expressed in podocytes and acts as a scavenger receptor for oxidized low-density lipoprotein.
The American journal of pathology 2009;174(6):2061-72.
2009: Nieuwenhuis Barbara; Lüth Anja; Chun Jerold; Huwiler Andrea; Pfeilschifter Josef; Schäfer-Korting Monika; Kleuser Burkhard
Involvement of the ABC-transporter ABCC1 and the sphingosine 1-phosphate receptor subtype S1P(3) in the cytoprotection of human fibroblasts by the glucocorticoid dexamethasone.
Journal of molecular medicine (Berlin, Germany) 2009;87(6):645-57.
2009: Jespersen Christine; Doller Anke; Akool El-Sayed; Bachmann Malte; Müller Roswitha; Gutwein Paul; Mühl Heiko; Pfeilschifter Josef; Eberhardt Wolfgang
Molecular mechanisms of nitric oxide-dependent inhibition of TPA-induced matrix metalloproteinase-9 (MMP-9) in MCF-7 cells.
Journal of cellular physiology 2009;219(2):276-87.
2009: Alban Susanne; Ludwig Ralf J; Bendas Gerd; Schön Michael P; Oostingh Gertie J; Radeke Heinfried H; Fritzsche Juliane; Pfeilschifter Josef; Kaufmann Roland; Boehncke Wolf-Henning
PS3, a semisynthetic beta-1,3-glucan sulfate, diminishes contact hypersensitivity responses through inhibition of L- and P-selectin functions.
The Journal of investigative dermatology 2009;129(5):1192-202.
2009: Doller Anke; Gauer Stefan; Sobkowiak Ewelina; Geiger Helmut; Pfeilschifter Josef; Eberhardt Wolfgang
Angiotensin II induces renal plasminogen activator inhibitor-1 and cyclooxygenase-2 expression post-transcriptionally via activation of the mRNA-stabilizing factor human-antigen R.
The American journal of pathology 2009;174(4):1252-63.
2009: Gutwein Paul; Schramme Anja; Voss Beren; Abdel-Bakky Mohamed Sadek; Doberstein Kai; Ludwig Andreas; Altevogt Peter; Hansmann Martin-Leo; Moch Holger; Kristiansen Glen; Pfeilschifter Josef
Downregulation of junctional adhesion molecule-A is involved in the progression of clear cell renal cell carcinoma.
Biochemical and biophysical research communications 2009;380(2):387-91.
2009: Schürmann Christoph; Seitz Oliver; Klein Cornelius; Sader Robert; Pfeilschifter Josef; Mühl Heiko; Goren Itamar; Frank Stefan
Tight spatial and temporal control in dynamic basal to distal migration of epithelial inflammatory responses and infiltration of cytoprotective macrophages determine healing skin flap transplants in mice.
Annals of surgery 2009;249(3):519-34.
2009: Goren Itamar; Müller Elke; Schiefelbein Dana; Gutwein Paul; Seitz Oliver; Pfeilschifter Josef; Frank Stefan
Akt1 controls insulin-driven VEGF biosynthesis from keratinocytes: implications for normal and diabetes-impaired skin repair in mice.
The Journal of investigative dermatology 2009;129(3):752-64.
2009: Gutwein Paul; Schramme Anja; Sinke Nina; Abdel-Bakky Mohamed Sadek; Voss Beren; Obermüller Nicholas; Doberstein Kai; Koziolek Michael; Fritzsche Florian; Johannsen Manfred; Jung Klaus; Schaider Helmut; Altevogt Peter; Ludwig Andreas; Pfeilschifter Josef; Kristiansen Glen
Tumoural CXCL16 expression is a novel prognostic marker of longer survival times in renal cell cancer patients.
European journal of cancer (Oxford, England : 1990) 2009;45(3):478-89.
2008: Doller Anke; Pfeilschifter Josef; Eberhardt Wolfgang
Signalling pathways regulating nucleo-cytoplasmic shuttling of the mRNA-binding protein HuR.
Cellular signalling 2008;20(12):2165-73.
2008: Hofmann Lotte P; Ren Shuyu; Schwalm Stephanie; Pfeilschifter Josef; Huwiler Andrea
Sphingosine kinase 1 and 2 regulate the capacity of mesangial cells to resist apoptotic stimuli in an opposing manner.
Biological chemistry 2008;389(11):1399-407.
2008: Schiefelbein Dana; Seitz Oliver; Goren Itamar; Dissmann Jan Philipp; Schmidt Helmut; Bachmann Malte; Sader Robert; Geisslinger Gerd; Pfeilschifter Josef; Frank Stefan
Keratinocyte-derived vascular endothelial growth factor biosynthesis represents a pleiotropic side effect of peroxisome proliferator-activated receptor-gamma agonist troglitazone but not rosiglitazone and involves activation of p38 mitogen-activated protein kinase: implications for diabetes-impaired skin repair.
Molecular pharmacology 2008;74(4):952-63.
2008: Akool El-Sayed; Doller Anke; Babelova Andrea; Tsalastra Wasiliki; Moreth Kristin; Schaefer Liliana; Pfeilschifter Josef; Eberhardt Wolfgang
Molecular mechanisms of TGF beta receptor-triggered signaling cascades rapidly induced by the calcineurin inhibitors cyclosporin A and FK506.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(4):2831-45.
2008: Schramme Anja; Abdel-Bakky Mohamed Sadek; Gutwein Paul; Obermüller Nicholas; Baer Patrick C; Hauser Ingeborg A; Ludwig Andreas; Gauer Stefan; Schäfer Liliana; Sobkowiak Ewelina; Altevogt Peter; Koziolek Michael; Kiss Eva; Gröne Hermann-Josef; Tikkanen Ritva; Goren Itamar; Radeke Heinfried; Pfeilschifter Josef
Characterization of CXCL16 and ADAM10 in the normal and transplanted kidney.
Kidney international 2008;74(3):328-38.
2008: Goren Itamar; Müller Elke; Pfeilschifter Josef; Frank Stefan
Thr308 determines Akt1 nuclear localization in insulin-stimulated keratinocytes.
Biochemical and biophysical research communications 2008;372(1):103-7.
2008: Janot Laure; Secher Thomas; Torres David; Maillet Isabelle; Pfeilschifter Josef; Quesniaux Valerie F J; Landmann Regine; Ryffel Bernhard; Erard François
CD14 works with toll-like receptor 2 to contribute to recognition and control of Listeria monocytogenes infection.
The Journal of infectious diseases 2008;198(1):115-24.
2008: Holdener Martin; Hintermann Edith; Bayer Monika; Rhode Antje; Rodrigo Evelyn; Hintereder Gudrun; Johnson Eric F; Gonzalez Frank J; Pfeilschifter Josef; Manns Michael P; Herrath Matthias von G; Christen Urs
Breaking tolerance to the natural human liver autoantigen cytochrome P450 2D6 by virus infection.
The Journal of experimental medicine 2008;205(6):1409-22.
2008: Schiefelbein Dana; Goren Itamar; Fisslthaler Beate; Schmidt Helmut; Geisslinger Gerd; Pfeilschifter Josef; Frank Stefan
Biphasic regulation of HMG-CoA reductase expression and activity during wound healing and its functional role in the control of keratinocyte angiogenic and proliferative responses.
The Journal of biological chemistry 2008;283(22):15479-90.
2008: Schramme Anja; Abdel-Bakky Mohamed Sadek; Kämpfer-Kolb Nicole; Pfeilschifter Josef; Gutwein Paul
The role of CXCL16 and its processing metalloproteinases ADAM10 and ADAM17 in the proliferation and migration of human mesangial cells.
Biochemical and biophysical research communications 2008;370(2):311-6.
2008: Poleganov Marco A; Bachmann Malte; Pfeilschifter Josef; Mühl Heiko
Genome-wide analysis displays marked induction of EBI3/IL-27B in IL-18-activated AML-derived KG1 cells: critical role of two kappaB binding sites in the human EBI3 promotor.
Molecular immunology 2008;45(10):2869-80.
2008: Huwiler Andrea; Pfeilschifter Josef
New players on the center stage: sphingosine 1-phosphate and its receptors as drug targets.
Biochemical pharmacology 2008;75(10):1893-900.
2008: Hoegl Sandra; Boost Kim A; Flondor Michael; Scheiermann Patrick; Muhl Heiko; Pfeilschifter Josef; Zwissler Bernhard; Hofstetter Christian
Short-term exposure to high-pressure ventilation leads to pulmonary biotrauma and systemic inflammation in the rat.
International journal of molecular medicine 2008;21(4):513-9.
2008: Doller Anke; Akool El-Sayed; Huwiler Andrea; Müller Roswitha; Radeke Heinfried H; Pfeilschifter Josef; Eberhardt Wolfgang
Posttranslational modification of the AU-rich element binding protein HuR by protein kinase Cdelta elicits angiotensin II-induced stabilization and nuclear export of cyclooxygenase 2 mRNA.
Molecular and cellular biology 2008;28(8):2608-25.
2008: Schwalm Stephanie; Döll Frauke; Römer Isolde; Bubnova Svetlana; Pfeilschifter Josef; Huwiler Andrea
Sphingosine kinase-1 is a hypoxia-regulated gene that stimulates migration of human endothelial cells.
Biochemical and biophysical research communications 2008;368(4):1020-5.
2008: Boost Kim A; Sadik Christian D; Bachmann Malte; Zwissler Bernhard; Pfeilschifter Josef; Mühl Heiko
IFN-gamma impairs release of IL-8 by IL-1beta-stimulated A549 lung carcinoma cells.
BMC cancer 2008;8():265.
2008: Sadik Christian D; Hunfeld Klaus-Peter; Bachmann Malte; Kraiczy Peter; Eberhardt Wolfgang; Brade Volker; Pfeilschifter Josef; Mühl Heiko
Systematic analysis highlights the key role of TLR2/NF-kappaB/MAP kinase signaling for IL-8 induction by macrophage-like THP-1 cells under influence of Borrelia burgdorferi lysates.
The international journal of biochemistry & cell biology 2008;40(11):2508-21.
2007: Poleganov Marco A; Pfeilschifter Josef; Mühl Heiko
Expanding extracellular zinc beyond levels reflecting the albumin-bound plasma zinc pool potentiates the capability of IL-1beta, IL-18, and IL-12 to Act as IFN-gamma-inducing factors on PBMC.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2007;27(12):997-1001.
2007: Nold Marcel F; Nold-Petry Claudia A; Fischer Doris; Richter Bernd; Blaheta Roman; Pfeilschifter Josef; Muhl Heiko; Schranz Dietmar; Veldman Alex
Activated protein C downregulates p38 mitogen-activated protein kinase and improves clinical parameters in an in-vivo model of septic shock.
Thrombosis and haemostasis 2007;98(5):1118-26.
2007: Gauer S; Sichler O; Obermüller N; Holzmann Y; Kiss E; Sobkowiak E; Pfeilschifter J; Geiger H; Mühl H; Hauser I A
IL-18 is expressed in the intercalated cell of human kidney.
Kidney international 2007;72(9):1081-7.
2007: Hofstetter Christian; Boost Kim A; Hoegl Sandra; Flondor Michael; Scheller Bertram; Muhl Heiko; Pfeilschifter Josef; Zwissler Bernhard
Norepinephrine and vasopressin counteract anti-inflammatory effects of isoflurane in endotoxemic rats.
International journal of molecular medicine 2007;20(4):597-604.
2007: Xin Cuiyan; Ren Shuyu; Eberhardt Wolfgang; Pfeilschifter Josef; Huwiler Andrea
Sphingosylphosphorylcholine acts in an anti-inflammatory manner in renal mesangial cells by reducing interleukin-1beta-induced prostaglandin E2 formation.
Journal of lipid research 2007;48(9):1985-96.
2007: Goren Itamar; Müller Elke; Schiefelbein Dana; Christen Urs; Pfeilschifter Josef; Mühl Heiko; Frank Stefan
Systemic anti-TNFalpha treatment restores diabetes-impaired skin repair in ob/ob mice by inactivation of macrophages.
The Journal of investigative dermatology 2007;127(9):2259-67.
2007: Luchtefeld Maren; Bandlow Nele; Tietge Uwe J F; Grote Karsten; Pfeilschifter Josef; Kaszkin Marietta; Beck Sabine; Drexler Helmut; Schieffer Bernhard
Angiotensin II type 1-receptor antagonism prevents type IIA secretory phospholipase A2-dependent lipid peroxidation.
Atherosclerosis 2007;194(1):62-70.
2007: Eberhardt W; Pfeilschifter J
Nitric oxide and vascular remodeling: spotlight on the kidney.
Kidney international. Supplement 2007;(106):S9-S16.
2007: Hofstetter C; Boost K A; Flondor M; Basagan-Mogol E; Betz C; Homann M; Muhl H; Pfeilschifter J; Zwissler B
Anti-inflammatory effects of sevoflurane and mild hypothermia in endotoxemic rats.
Acta anaesthesiologica Scandinavica 2007;51(7):893-9.
2007: Döll Frauke; Pfeilschifter Josef; Huwiler Andrea
Prolactin upregulates sphingosine kinase-1 expression and activity in the human breast cancer cell line MCF7 and triggers enhanced proliferation and migration.
Endocrine-related cancer 2007;14(2):325-35.
2007: Ziesché Elisabeth; Bachmann Malte; Kleinert Hartmut; Pfeilschifter Josef; Mühl Heiko
The interleukin-22/STAT3 pathway potentiates expression of inducible nitric-oxide synthase in human colon carcinoma cells.
The Journal of biological chemistry 2007;282(22):16006-15.
2007: Doller Anke; Huwiler Andrea; Müller Roswitha; Radeke Heinfried H; Pfeilschifter Josef; Eberhardt Wolfgang
Protein kinase C alpha-dependent phosphorylation of the mRNA-stabilizing factor HuR: implications for posttranscriptional regulation of cyclooxygenase-2.
Molecular biology of the cell 2007;18(6):2137-48.
2007: Boost Kim A; Hoegl Sandra; Hofstetter Christian; Flondor Michael; Stegewerth Klaus; Platacis Ilka; Pfeilschifter Josef; Muhl Heiko; Zwissler Bernhard
Targeting caspase-1 by inhalation-therapy: effects of Ac-YVAD-CHO on IL-1 beta, IL-18 and downstream proinflammatory parameters as detected in rat endotoxaemia.
Intensive care medicine 2007;33(5):863-71.
2007: Schacke Wolfgang; Beck Karl-Friedrich; Pfeilschifter Josef; Hattenbach Lars-Olof
Expression of ubiquitin carboxy-terminal hydrolase-l1 in photocoagulated human retinal pigment epithelial cells.
Current eye research 2007;32(4):367-72.
2007: Xin C; Ren S; Eberhardt W; Pfeilschifter J; Huwiler A
FTY720 suppresses interleukin-1beta-induced secretory phospholipase A2 expression in renal mesangial cells by a transcriptional mechanism.
British journal of pharmacology 2007;150(7):943-50.
2007: Eberhardt Wolfgang; Doller Anke; Akool El-Sayed; Pfeilschifter Josef
Modulation of mRNA stability as a novel therapeutic approach.
Pharmacology & therapeutics 2007;114(1):56-73.
2007: Bachmann Malte; Dragoi Cristina; Poleganov Marco A; Pfeilschifter Josef; Mühl Heiko
Interleukin-18 directly activates T-bet expression and function via p38 mitogen-activated protein kinase and nuclear factor-kappaB in acute myeloid leukemia-derived predendritic KG-1 cells.
Molecular cancer therapeutics 2007;6(2):723-31.
2007: Doller Anke; Akool El-Sayed; Müller Roswitha; Gutwein Paul; Kurowski Christine; Pfeilschifter Josef; Eberhardt Wolfgang
Molecular mechanisms of cyclosporin A inhibition of the cytokine-induced matrix metalloproteinase-9 in glomerular mesangial cells.
Journal of the American Society of Nephrology : JASN 2007;18(2):581-92.
2007: Klawitter S; Hofmann L P; Pfeilschifter J; Huwiler A
Extracellular nucleotides induce migration of renal mesangial cells by upregulating sphingosine kinase-1 expression and activity.
British journal of pharmacology 2007;150(3):271-80.
2007: Schaefer Liliana; Tsalastra Wasiliki; Babelova Andrea; Baliova Martina; Minnerup Jens; Sorokin Lydia; Gröne Hermann-Josef; Reinhardt Dieter P; Pfeilschifter Josef; Iozzo Renato V; Schaefer Roland M
Decorin-mediated regulation of fibrillin-1 in the kidney involves the insulin-like growth factor-I receptor and Mammalian target of rapamycin.
The American journal of pathology 2007;170(1):301-15.
2006: Huwiler Andrea; Pfeilschifter Josef
Hypoxia and lipid signaling.
Biological chemistry 2006;387(10-11):1321-8.
2006: Beck S; Beck G; Ostendorf T; Floege J; Lambeau G; Nevalainen T; Radeke H H; Gurrieri S; Haas U; Thorwart B; Pfeilschifter J; Kaszkin M
Upregulation of group IB secreted phospholipase A(2) and its M-type receptor in rat ANTI-THY-1 glomerulonephritis.
Kidney international 2006;70(7):1251-60.
2006: Boost Kim A; Hofstetter Christian; Flondor Michael; Betz Christian; Homann Markus; Pfeilschifter Josef; Muehl Heiko; Zwissler Bernhard
Desflurane differentially affects the release of proinflammatory cytokines in plasma and bronchoalveolar fluid of endotoxemic rats.
International journal of molecular medicine 2006;17(6):1139-44.
2006: Mühl Heiko; Pfeilschifter Josef
Controlling the cytokine storm by insulin: glycogen synthase kinase-3 as a target in systemic inflammation.
Critical care medicine 2006;34(5):1567-9.
2006: Huwiler Andrea; Döll Frauke; Ren Shuyu; Klawitter Sabine; Greening Anna; Römer Isolde; Bubnova Svetlana; Reinsberg Luise; Pfeilschifter Josef
Histamine increases sphingosine kinase-1 expression and activity in the human arterial endothelial cell line EA.hy 926 by a PKC-alpha-dependent mechanism.
Biochimica et biophysica acta 2006;1761(3):367-76.
2006: Goren Itamar; Müller Elke; Pfeilschifter Josef; Frank Stefan
Severely impaired insulin signaling in chronic wounds of diabetic ob/ob mice: a potential role of tumor necrosis factor-alpha.
The American journal of pathology 2006;168(3):765-77.
2006: Goren Itamar; Kämpfer Heiko; Müller Elke; Schiefelbein Dana; Pfeilschifter Josef; Frank Stefan
Oncostatin M expression is functionally connected to neutrophils in the early inflammatory phase of skin repair: implications for normal and diabetes-impaired wounds.
The Journal of investigative dermatology 2006;126(3):628-37.
2006: Bachmann Malte; Horn Katharina; Poleganov Marco A; Paulukat Jens; Nold Marcel; Pfeilschifter Josef; Mühl Heiko
Interleukin-18 secretion and Th1-like cytokine responses in human peripheral blood mononuclear cells under the influence of the toll-like receptor-5 ligand flagellin.
Cellular microbiology 2006;8(2):289-300.
2006: Goren Itamar; Linke Andreas; Müller Elke; Pfeilschifter Josef; Frank Stefan
The suppressor of cytokine signaling-3 is upregulated in impaired skin repair: implications for keratinocyte proliferation.
The Journal of investigative dermatology 2006;126(2):477-85.
2006: Xin Cuiyan; Ren Shuyu; Eberhardt Wolfgang; Pfeilschifter Josef; Huwiler Andrea
The immunomodulator FTY720 and its phosphorylated derivative activate the Smad signalling cascade and upregulate connective tissue growth factor and collagen type IV expression in renal mesangial cells.
British journal of pharmacology 2006;147(2):164-74.
2006: Plesková Miriam; Beck Karl-Friedrich; Behrens Meik Helmut; Huwiler Andrea; Fichtlscherer Birgit; Wingerter Oliver; Brandes Ralf P; Mülsch Alexander; Pfeilschifter Josef
Nitric oxide down-regulates the expression of the catalytic NADPH oxidase subunit Nox1 in rat renal mesangial cells.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(1):139-41.
2006: Huwiler Andrea; Pfeilschifter Josef
Altering the sphingosine-1-phosphate/ceramide balance: a promising approach for tumor therapy.
Current pharmaceutical design 2006;12(35):4625-35.
2005: Döll Frauke; Pfeilschifter Josef; Huwiler Andrea
The epidermal growth factor stimulates sphingosine kinase-1 expression and activity in the human mammary carcinoma cell line MCF7.
Biochimica et biophysica acta 2005;1738(1-3):72-81.
2005: Ren Shuyu; Xin Cuiyan; Beck Karl-Friedrich; Saleem Moin A; Mathieson Peter; Pavenstädt Hermann; Pfeilschifter Josef; Huwiler Andrea
PPARalpha activation upregulates nephrin expression in human embryonic kidney epithelial cells and podocytes by a dual mechanism.
Biochemical and biophysical research communications 2005;338(4):1818-24.
2005: Akool El-Sayed; Doller Anke; Müller Roswitha; Gutwein Paul; Xin Cuiyan; Huwiler Andrea; Pfeilschifter Josef; Eberhardt Wolfgang
Nitric oxide induces TIMP-1 expression by activating the transforming growth factor beta-Smad signaling pathway.
The Journal of biological chemistry 2005;280(47):39403-16.
2005: Hattenbach Lars-Olof; Beck Karl-Friedrich; Pfeilschifter Josef; Koch Frank; Ohrloff Christian; Schacke Wolfgang
Pigment-epithelium-derived factor is upregulated in photocoagulated human retinal pigment epithelial cells.
Ophthalmic research 2005;37(6):341-6.
2005: Petry Claudia; Huwiler Andrea; Eberhardt Wolfgang; Kaszkin Marietta; Pfeilschifter Josef
Hypoxia increases group IIA phospholipase A(2) expression under inflammatory conditions in rat renal mesangial cells.
Journal of the American Society of Nephrology : JASN 2005;16(10):2897-905.
2005: Hofstetter Christian; Flondor Michael; Boost Kim A; Koehler Patricia; Bosmann Markus; Pfeilschifter Josef; Zwissler Bernhard; Mühl Heiko
A brief exposure to isoflurane (50 s) significantly impacts on plasma cytokine levels in endotoxemic rats.
International immunopharmacology 2005;5(10):1519-22.
2005: Eberhardt Wolfgang; Kilz Tobias; Akool El-Sayed; Müller Roswitha; Pfeilschifter Josef
Dissociated glucocorticoids equipotently inhibit cytokine- and cAMP-induced matrix degrading proteases in rat mesangial cells.
Biochemical pharmacology 2005;70(3):433-45.
2005: Beck Karl-Friedrich; Güder Gülmisal; Schaefer Liliana; Pleskova Miriam; Babelova Andrea; Behrens Meik H; Mihalik Daniel; Beck Martina; Schaefer Roland M; Pfeilschifter Josef
Nitric oxide upregulates induction of PDGF receptor-alpha expression in rat renal mesangial cells and in anti-Thy-1 glomerulonephritis.
Journal of the American Society of Nephrology : JASN 2005;16(7):1948-57.
2005: Vlachojannis G J; Scholz-Pedretti K; Fierlbeck W; Geiger H; Pfeilschifter J; Kaszkin M
Enhanced expression of group IIA secreted phospholipase A2 by elevated glucose levels in cytokine-stimulated rat mesangial cells and in kidneys of diabetic rats.
Clinical nephrology 2005;63(5):356-67.
2005: Kämpfer Heiko; Schmidt Ronald; Geisslinger Gerd; Pfeilschifter Josef; Frank Stefan
Wound inflammation in diabetic ob/ob mice: functional coupling of prostaglandin biosynthesis to cyclooxygenase-1 activity in diabetes-impaired wound healing.
Diabetes 2005;54(5):1543-51.
2005: Djordjevic Talija; BelAiba Rachida S; Bonello Steve; Pfeilschifter Josef; Hess John; Görlach Agnes
Human urotensin II is a novel activator of NADPH oxidase in human pulmonary artery smooth muscle cells.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(3):519-25.
2005: Haas Ulrike; Podda Maurizio; Behne Martin; Gurrieri Silvia; Alonso Angel; Fürstenberger Gerhard; Pfeilschifter Josef; Lambeau Gérard; Gelb Michael H; Kaszkin Marietta
Characterization and differentiation-dependent regulation of secreted phospholipases A in human keratinocytes and in healthy and psoriatic human skin.
The Journal of investigative dermatology 2005;124(1):204-11.
2004: Sun Mei; Kong Lingxin; Wang Xiaodan; Holmes Courtney; Gao Qingsheng; Zhang Guo-Rong; Pfeilschifter Josef; Goldstein David S; Geller Alfred I
Coexpression of tyrosine hydroxylase, GTP cyclohydrolase I, aromatic amino acid decarboxylase, and vesicular monoamine transporter 2 from a helper virus-free herpes simplex virus type 1 vector supports high-level, long-term biochemical and behavioral correction of a rat model of Parkinson's disease.
Human gene therapy 2004;15(12):1177-96.
2004: Mühl Heiko; Paulukat Jens; Höfler Sonja; Hellmuth Markus; Franzen Rochus; Pfeilschifter Josef
The HIV protease inhibitor ritonavir synergizes with butyrate for induction of apoptotic cell death and mediates expression of heme oxygenase-1 in DLD-1 colon carcinoma cells.
British journal of pharmacology 2004;143(7):890-8.
2004: Xin Cuiyan; Ren Shuyu; Pfeilschifter Josef; Huwiler Andrea
Heterologous desensitization of the sphingosine-1-phosphate receptors by purinoceptor activation in renal mesangial cells.
British journal of pharmacology 2004;143(5):581-9.
2004: Schaefer Liliana; Ren Shuyu; Schaefer Roland M; Mihalik Daniel; Babelova Andrea; Huwiler Andrea; Pfeilschifter Josef
Nephrin expression is increased in anti-Thy1.1-induced glomerulonephritis in rats.
Biochemical and biophysical research communications 2004;324(1):247-54.
2004: Mühl Heiko; Pfeilschifter Josef
Interleukin-18 bioactivity: a novel target for immunopharmacological anti-inflammatory intervention.
European journal of pharmacology 2004;500(1-3):63-71.
2004: Kahlina Kornelija; Goren Itamar; Pfeilschifter Josef; Frank Stefan
p68 DEAD box RNA helicase expression in keratinocytes. Regulation, nucleolar localization, and functional connection to proliferation and vascular endothelial growth factor gene expression.
The Journal of biological chemistry 2004;279(43):44872-82.
2004: Pfeilschifter Josef; Huwiler Andrea
Erythropoietin is more than just a promoter of erythropoiesis.
Journal of the American Society of Nephrology : JASN 2004;15(8):2240-1.
2004: Xin Cuiyan; Ren Shuyu; Kleuser Burkhardt; Shabahang Soheyla; Eberhardt Wolfgang; Radeke Heinfried; Schäfer-Korting Monika; Pfeilschifter Josef; Huwiler Andrea
Sphingosine 1-phosphate cross-activates the Smad signaling cascade and mimics transforming growth factor-beta-induced cell responses.
The Journal of biological chemistry 2004;279(34):35255-62.
2004: Hellmuth Markus; Paulukat Jens; Ninic Raiko; Pfeilschifter Josef; Mühl Heiko
Nitric oxide differentially regulates pro- and anti-angiogenic markers in DLD-1 colon carcinoma cells.
FEBS letters 2004;563(1-3):98-102.
2004: Huwiler Andrea; Xin Cuiyan; Brust Anja-Kristina; Briner Verena A; Pfeilschifter Josef
Differential binding of ceramide to MEKK1 in glomerular endothelial and mesangial cells.
Biochimica et biophysica acta 2004;1636(2-3):159-68.
2004: Petry Claudia; Fritz Gerhard; Pfeilschifter Josef; Huwiler Andrea
Inhibition of Rho modulates cytokine-induced prostaglandin E2 formation in renal mesangial cells.
Biochimica et biophysica acta 2004;1636(2-3):108-18.
2004: Chatterjee Prabal Kumar; Patel Nimesh S A; Cuzzocrea Salvatore; Brown Paul A J; Stewart Keith N; Mota-Filipe Helder; Britti Domenico; Eberhardt Wolfgang; Pfeilschifter Josef; Thiemermann Christoph
The cyclopentenone prostaglandin 15-deoxy-Delta(12,14)-prostaglandin J2 ameliorates ischemic acute renal failure.
Cardiovascular research 2004;61(3):630-43.
2004: Blume Cornelia; Sabuda-Widemann Danuta; Pfeilschifter Josef; Plum Jörg; Schrör K; Grabensee Bernd; Beck Karl-Friedrich
Cerivastatin inhibits proliferation of interleukin-1 beta-induced rat mesangial cells by enhanced formation of nitric oxide.
European journal of pharmacology 2004;485(1-3):1-10.
2004: Hocher Berthold; Schwarz Anja; Slowinski Torsten; Bachmann Sebastian; Pfeilschifter Josef; Neumayer Hans H; Bauer Christian
In-vivo interaction of nitric oxide and endothelin.
Journal of hypertension 2004;22(1):111-9.
2004: Kaszkin Marietta; Beck Karl-Friedrich; Eberhardt Wolfgang; Pfeilschifter Josef
Unravelling green tea's mechanisms of action: more than meets the eye.
Molecular pharmacology 2004;65(1):15-7.
2003: Keller Thorsten; Plesková Miriam; McDonald Michelle C; Thiemermann Christoph; Pfeilschifter Josef; Beck Karl-Friedrich
Identification of manganese superoxide dismutase as a NO-regulated gene in rat glomerular mesangial cells by 2D gel electrophoresis.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2003;9(4):183-93.
2003: Kämpfer Heiko; Pfeilschifter Josef; Frank Stefan
Expression and activity of arginase isoenzymes during normal and diabetes-impaired skin repair.
The Journal of investigative dermatology 2003;121(6):1544-51.
2003: Mühl Heiko; Höfler Sonja; Pfeilschifter Josef
Inhibition of lipopolysaccharide/ATP-induced release of interleukin-18 by KN-62 and glyburide.
European journal of pharmacology 2003;482(1-3):325-8.
2003: Huwiler Andrea; Akool el-Sayed; Aschrafi Armaz; Hamada Farid M A; Pfeilschifter Josef; Eberhardt Wolfgang
ATP potentiates interleukin-1 beta-induced MMP-9 expression in mesangial cells via recruitment of the ELAV protein HuR.
The Journal of biological chemistry 2003;278(51):51758-69.
2003: Goren Itamar; Kämpfer Heiko; Podda Maurizio; Pfeilschifter Josef; Frank Stefan
Leptin and wound inflammation in diabetic ob/ob mice: differential regulation of neutrophil and macrophage influx and a potential role for the scab as a sink for inflammatory cells and mediators.
Diabetes 2003;52(11):2821-32.
2003: El-Gayar Stefan; Thüring-Nahler Heike; Pfeilschifter Josef; Röllinghoff Martin; Bogdan Christian
Translational control of inducible nitric oxide synthase by IL-13 and arginine availability in inflammatory macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(9):4561-8.
2003: Huwiler Andrea; Pfeilschifter Josef
Nitric oxide signalling with a special focus on lipid-derived mediators.
Biological chemistry 2003;384(10-11):1379-89.
2003: Aschrafi Armaz; Franzen Rochus; Shabahang Soheyla; Fabbro Doriano; Pfeilschifter Josef; Huwiler Andrea
Ceramide induces translocation of protein kinase C-alpha to the Golgi compartment of human embryonic kidney cells by interacting with the C2 domain.
Biochimica et biophysica acta 2003;1634(1-2):30-9.
2003: Mühl Heiko; Pfeilschifter Josef
Endothelial nitric oxide synthase: a determinant of TNFalpha production by human monocytes/macrophages.
Biochemical and biophysical research communications 2003;310(3):677-80.
2003: Mühl Heiko; Pfeilschifter Josef
Anti-inflammatory properties of pro-inflammatory interferon-gamma.
International immunopharmacology 2003;3(9):1247-55.
2003: Nold Marcel; Hauser Ingeborg A; Höfler Sonja; Goede Andreas; Eberhardt Wolfgang; Ditting Till; Geiger Helmut; Pfeilschifter Josef; Mühl Heiko
IL-18BPa:Fc cooperates with immunosuppressive drugs in human whole blood.
Biochemical pharmacology 2003;66(3):505-10.
2003: Pfeilschifter Josef; Eberhardt Wolfgang; Huwiler Andrea
Nitric oxide and mechanisms of redox signaling.
Journal of the American Society of Nephrology : JASN 2003;14(8 Suppl 3):S237-40.
2003: Beck Sabine; Lambeau Gérard; Scholz-Pedretti Kristen; Gelb Michael H; Janssen Marcel J W; Edwards Suzanne H; Wilton David C; Pfeilschifter Josef; Kaszkin Marietta
Potentiation of tumor necrosis factor alpha-induced secreted phospholipase A2 (sPLA2)-IIA expression in mesangial cells by an autocrine loop involving sPLA2 and peroxisome proliferator-activated receptor alpha activation.
The Journal of biological chemistry 2003;278(32):29799-812.
2003: Deja Maria; Busch Thilo; Bachmann Sebastian; Riskowski Kerstin; Campean Valentina; Wiedmann Brigitte; Schwabe Michael; Hell Bertold; Pfeilschifter Josef; Falke Konrad J; Lewandowski Klaus
Reduced nitric oxide in sinus epithelium of patients with radiologic maxillary sinusitis and sepsis.
American journal of respiratory and critical care medicine 2003;168(3):281-6.
2003: Gurrieri Silvia; Fürstenberger Gerhard; Schadow Alexia; Haas Ulrike; Singer Alan G; Ghomashchi Farideh; Pfeilschifter Josef; Lambeau Gérard; Gelb Michael H; Kaszkin Marietta
Differentiation-dependent regulation of secreted phospholipases A2 in murine epidermis.
The Journal of investigative dermatology 2003;121(1):156-64.
2003: Akool El-Sayed; Kleinert Hartmut; Hamada Farid M A; Abdelwahab Mohamed H; Förstermann Ulrich; Pfeilschifter Josef; Eberhardt Wolfgang
Nitric oxide increases the decay of matrix metalloproteinase 9 mRNA by inhibiting the expression of mRNA-stabilizing factor HuR.
Molecular and cellular biology 2003;23(14):4901-16.
2003: Schaefer Liliana; Beck Karl-Friedrich; Raslik Igor; Walpen Sebastian; Mihalik Daniel; Micegova Miroslava; Macakova Katarina; Schonherr Elke; Seidler Daniela G; Varga Georg; Schaefer Roland M; Kresse Hans; Pfeilschifter Josef
Biglycan, a nitric oxide-regulated gene, affects adhesion, growth, and survival of mesangial cells.
The Journal of biological chemistry 2003;278(28):26227-37.
2003: Huwiler Andrea; Ren Shuyu; Holthöfer Harry; Pavenstädt Hermann; Pfeilschifter Josef
Inflammatory cytokines upregulate nephrin expression in human embryonic kidney epithelial cells and podocytes.
Biochemical and biophysical research communications 2003;305(1):136-42.
2003: Kämpfer Heiko; Bräutigam Lutz; Geisslinger Gerd; Pfeilschifter Josef; Frank Stefan
Cyclooxygenase-1-coupled prostaglandin biosynthesis constitutes an essential prerequisite for skin repair.
The Journal of investigative dermatology 2003;120(5):880-90.
2003: Goren Itamar; Pfeilschifter Josef; Frank Stefan
Determination of leptin signaling pathways in human and murine keratinocytes.
Biochemical and biophysical research communications 2003;303(4):1080-5.
2003: Möller B; Paulukat J; Nold M; Behrens M; Kukoc-Zivojnov N; Kaltwasser J P; Pfeilschifter J; Mühl H
Interferon-gamma induces expression of interleukin-18 binding protein in fibroblast-like synoviocytes.
Rheumatology (Oxford, England) 2003;42(3):442-5.
2003: Rölz Waltraud; Xin Cuiyan; Ren Shuyu; Pfeilschifter Josef; Huwiler Andrea
Interleukin-1beta inhibits ATP-induced protein kinase B activation in renal mesangial cells by two different mechanisms: the involvement of nitric oxide and ceramide.
British journal of pharmacology 2003;138(3):461-8.
2003: Nold Marcel; Goede Andreas; Eberhardt Wolfgang; Pfeilschifter Josef; Mühl Heiko
IL-18 initiates release of matrix metalloproteinase-9 from peripheral blood mononuclear cells without affecting tissue inhibitor of matrix metalloproteinases-1: suppression by TNF alpha blockage and modulation by IL-10.
Naunyn-Schmiedeberg's archives of pharmacology 2003;367(1):68-75.
2003: Bruch-Gerharz Daniela; Schnorr Oliver; Suschek Christoph; Beck Karl-Friedrich; Pfeilschifter Josef; Ruzicka Thomas; Kolb-Bachofen Victoria
Arginase 1 overexpression in psoriasis: limitation of inducible nitric oxide synthase activity as a molecular mechanism for keratinocyte hyperproliferation.
The American journal of pathology 2003;162(1):203-11.
2003: Heese Klaus; Beck Karl-Friedrich; Behrens Meik Helmut; Plüss Katharina; Fierlbeck Wolfgang; Huwiler Andrea; Mühl Heiko; Geiger Helmut; Otten Uwe; Pfeilschifter Josef
Effects of high glucose on cytokine-induced nerve growth factor (NGF) expression in rat renal mesangial cells.
Biochemical pharmacology 2003;65(2):293-301.
2003: Pfeilschifter Josef; Eberhardt Wolfgang; Beck Karl-Friedrich; Huwiler Andrea
Redox signaling in mesangial cells.
Nephron. Experimental nephrology 2003;93(1):e23-6.
2003: Mühl Heiko; Pfeilschifter Josef
[A short summary. The history of glucocorticoids]
Pharmazie in unserer Zeit 2003;32(4):284-7.
2002: Franzen Rochus; Pfeilschifter Josef; Huwiler Andrea
Nitric oxide induces neutral ceramidase degradation by the ubiquitin/proteasome complex in renal mesangial cell cultures.
FEBS letters 2002;532(3):441-4.
2002: Shabahang Soheyla; Liu Yan-Hong; Huwiler Andrea; Pfeilschifter Josef
Identification of the LIM kinase-1 as a ceramide-regulated gene in renal mesangial cells.
Biochemical and biophysical research communications 2002;298(3):408-13.
2002: Franzen Rochus; Fabbro Doriano; Aschrafi Armaz; Pfeilschifter Josef; Huwiler Andrea
Nitric oxide induces degradation of the neutral ceramidase in rat renal mesangial cells and is counterregulated by protein kinase C.
The Journal of biological chemistry 2002;277(48):46184-90.
2002: Li Huige; Junk Peter; Huwiler Andrea; Burkhardt Christian; Wallerath Thomas; Pfeilschifter Josef; Förstermann Ulrich
Dual effect of ceramide on human endothelial cells: induction of oxidative stress and transcriptional upregulation of endothelial nitric oxide synthase.
Circulation 2002;106(17):2250-6.
2002: Eberhardt Wolfgang; Engels Christina; Müller Roswitha; Pfeilschifter Josef
Mechanisms of dexamethasone-mediated inhibition of cAMP-induced tPA expression in rat mesangial cells.
Kidney international 2002;62(3):809-21.
2002: Eberhardt Wolfgang; Akool El-Sayed; Rebhan Jorg; Frank Stefan; Beck Karl-Friedrich; Franzen Rochus; Hamada Farid M A; Pfeilschifter Josef
Inhibition of cytokine-induced matrix metalloproteinase 9 expression by peroxisome proliferator-activated receptor alpha agonists is indirect and due to a NO-mediated reduction of mRNA stability.
The Journal of biological chemistry 2002;277(36):33518-28.
2002: Hellmuth Markus; Wetzler Christian; Nold Marcel; Chang Jae-Hyung; Frank Stefan; Pfeilschifter Josef; Mühl Heiko
Expression of interleukin-8, heme oxygenase-1 and vascular endothelial growth factor in DLD-1 colon carcinoma cells exposed to pyrrolidine dithiocarbamate.
Carcinogenesis 2002;23(8):1273-9.
2002: Schacke Wolfgang; Beck Karl-Friedrich; Pfeilschifter Josef; Koch Frank; Hattenbach Lars-Olof
Modulation of tissue plasminogen activator and plasminogen activator inhibitor-1 by transforming growth factor-beta in human retinal glial cells.
Investigative ophthalmology & visual science 2002;43(8):2799-805.
2002: Eberhardt Wolfgang; Schulze Maja; Engels Christina; Klasmeier Elke; Pfeilschifter Josef
Glucocorticoid-mediated suppression of cytokine-induced matrix metalloproteinase-9 expression in rat mesangial cells: involvement of nuclear factor-kappaB and Ets transcription factors.
Molecular endocrinology (Baltimore, Md.) 2002;16(8):1752-66.
2002: Huwiler Andrea; Rölz Waltraud; Dorsch Simone; Ren Shuyu; Pfeilschifter Josef
Extracellular ATP and UTP activate the protein kinase B/Akt cascade via the P2Y(2) purinoceptor in renal mesangial cells.
British journal of pharmacology 2002;136(4):520-9.
2002: Rölz Waltraud; Xin Cuiyan; Ren Shuyu; Pfeilschifter Josef; Huwiler Andrea
Interleukin-1 inhibits angiotensin II-stimulated protein kinase B pathway in renal mesangial cells via the inducible nitric oxide synthase.
European journal of pharmacology 2002;442(3):195-203.
2002: Stallmeyer Birgit; Anhold Manuel; Wetzler Christian; Kahlina Kornelija; Pfeilschifter Josef; Frank Stefan
Regulation of eNOS in normal and diabetes-impaired skin repair: implications for tissue regeneration.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2002;6(2):168-77.
2002: Pfeilschifter Josef
Nitric oxide triggers the expression of proinflammatory and protective gene products in mesangial cells and the inflamed glomerulus.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2002;17(3):347-8.
2002: Scholz-Pedretti Kirsten; Gans Annette; Beck Karl-Friedrich; Pfeilschifter Josef; Kaszkin Marietta
Potentiation of TNF-alpha-stimulated group IIA phospholipase A(2) expression by peroxisome proliferator-activated receptor alpha activators in rat mesangial cells.
Journal of the American Society of Nephrology : JASN 2002;13(3):611-20.
2002: Frank Stefan; Kämpfer Heiko; Wetzler Christian; Pfeilschifter Josef
Nitric oxide drives skin repair: novel functions of an established mediator.
Kidney international 2002;61(3):882-8.
2002: Pfeilschifter Josef; Beck Karl-Friedrich; Eberhardt Wolfgang; Huwiler Andrea
Changing gears in the course of glomerulonephritis by shifting superoxide to nitric oxide-dominated chemistry.
Kidney international 2002;61(3):809-15.
2002: Manderscheid Markus; Pereda-Fernández Carmen; Pfeilschifter Josef
Cyclic AMP increases rat inhibitor of apoptosis protein (RIAP1) mRNA in renal mesangial cells.
Kidney international 2002;61(3):797-803.
2002: Pautz Andrea; Franzen Rochus; Dorsch Simone; Böddinghaus Boris; Briner Verena A; Pfeilschifter Josef; Huwiler Andrea
Cross-talk between nitric oxide and superoxide determines ceramide formation and apoptosis in glomerular cells.
Kidney international 2002;61(3):790-6.
2002: Eberhardt Wolfgang; Beck Karl-Friedrich; Pfeilschifter Josef
Cytokine-induced expression of tPA is differentially modulated by NO and ROS in rat mesangial cells.
Kidney international 2002;61(1):20-30.
2001: Walker G; Pfeilschifter J; Otten U; Kunz D
Proteolytic cleavage of inducible nitric oxide synthase (iNOS) by calpain I.
Biochimica et biophysica acta 2001;1568(3):216-24.
2001: Paulukat J; Bosmann M; Nold M; Garkisch S; Kämpfer H; Frank S; Raedle J; Zeuzem S; Pfeilschifter J; Mühl H
Expression and release of IL-18 binding protein in response to IFN-gamma.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(12):7038-43.
2001: Beck K F; Walpen S; Eberhardt W; Pfeilschifter J
Downregulation of integrin-linked kinase mRNA expression by nitric oxide in rat glomerular mesangial cells.
Life sciences 2001;69(25-26):2945-55.
2001: Pfeilschifter J; Eberhardt W; Huwiler A
Nitric oxide and mechanisms of redox signalling: matrix and matrix-metabolizing enzymes as prime nitric oxide targets.
European journal of pharmacology 2001;429(1-3):279-86.
2001: Tegeder I; Pfeilschifter J; Geisslinger G
Cyclooxygenase-independent actions of cyclooxygenase inhibitors.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(12):2057-72.
2001: Franzen R; Pautz A; Bräutigam L; Geisslinger G; Pfeilschifter J; Huwiler A
Interleukin-1beta induces chronic activation and de novo synthesis of neutral ceramidase in renal mesangial cells.
The Journal of biological chemistry 2001;276(38):35382-9.
2001: Kämpfer H; Kolb N; Manderscheid M; Wetzler C; Pfeilschifter J; Frank S
Macrophage-derived heme-oxygenase-1: expression, regulation, and possible functions in skin repair.
Molecular medicine (Cambridge, Mass.) 2001;7(7):488-98.
2001: Stallmeyer B; Kämpfer H; Podda M; Kaufmann R; Pfeilschifter J; Frank S
A novel keratinocyte mitogen: regulation of leptin and its functional receptor in skin repair.
The Journal of investigative dermatology 2001;117(1):98-105.
2001: Messmer U K; Pereda-Fernandez C; Manderscheid M; Pfeilschifter J
Dexamethasone inhibits TNF-alpha-induced apoptosis and IAP protein downregulation in MCF-7 cells.
British journal of pharmacology 2001;133(4):467-76.
2001: Huwiler A; Böddinghaus B; Pautz A; Dorsch S; Franzen R; Briner V A; Brade V; Pfeilschifter J
Superoxide potently induces ceramide formation in glomerular endothelial cells.
Biochemical and biophysical research communications 2001;284(2):404-10.
2001: Manderscheid M; Messmer U K; Franzen R; Pfeilschifter J
Regulation of inhibitor of apoptosis expression by nitric oxide and cytokines: relation to apoptosis induction in rat mesangial cells and raw 264.7 macrophages.
Journal of the American Society of Nephrology : JASN 2001;12(6):1151-63.
2001: Stallmeyer B; Pfeilschifter J; Frank S
Systemically and topically supplemented leptin fails to reconstitute a normal angiogenic response during skin repair in diabetic ob/ob mice.
Diabetologia 2001;44(4):471-9.
2001: Walpen S; Beck K F; Schaefer L; Raslik I; Eberhardt W; Schaefer R M; Pfeilschifter J
Nitric oxide induces MIP-2 transcription in rat renal mesangial cells and in a rat model of glomerulonephritis.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(3):571-3.
2001: Schadow A; Scholz-Pedretti K; Lambeau G; Gelb M H; Fürstenberger G; Pfeilschifter J; Kaszkin M
Characterization of group X phospholipase A(2) as the major enzyme secreted by human keratinocytes and its regulation by the phorbol ester TPA.
The Journal of investigative dermatology 2001;116(1):31-9.
2001: Scholz-Pedretti K; Pfeilschifter J; Kaszkin M
Potentiation of cytokine induction of group IIA phospholipase A(2) in rat mesangial cells by ATP and adenosine via the A2A adenosine receptor.
British journal of pharmacology 2001;132(1):37-46.
2001: Huwiler A; Johansen B; Skarstad A; Pfeilschifter J
Ceramide binds to the CaLB domain of cytosolic phospholipase A2 and facilitates its membrane docking and arachidonic acid release.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(1):7-9.
2000: Kämpfer H; Paulukat J; Mühl H; Wetzler C; Pfeilschifter J; Frank S
Lack of interferon-gamma production despite the presence of interleukin-18 during cutaneous wound healing.
Molecular medicine (Cambridge, Mass.) 2000;6(12):1016-27.
2000: Kämpfer H; Mühl H; Manderscheid M; Kalina U; Kauschat D; Pfeilschifter J; Frank S
Regulation of interleukin-18 (IL-18) expression in keratinocytes (HaCaT): implications for early wound healing.
European cytokine network 2000;11(4):626-33.
2000: Messmer U K; Briner V A; Pfeilschifter J
Basic fibroblast growth factor selectively enhances TNF-alpha-induced apoptotic cell death in glomerular endothelial cells: effects on apoptotic signaling pathways.
Journal of the American Society of Nephrology : JASN 2000;11(12):2199-211.
2000: Mühl H; Chang J H; Huwiler A; Bosmann M; Paulukat J; Ninic R; Nold M; Hellmuth M; Pfeilschifter J
Nitric oxide augments release of chemokines from monocytic U937 cells: modulation by anti-inflammatory pathways.
Free radical biology & medicine 2000;29(10):969-80.
2000: Eberhardt W; Huwiler A; Beck K F; Walpen S; Pfeilschifter J
Amplification of IL-1 beta-induced matrix metalloproteinase-9 expression by superoxide in rat glomerular mesangial cells is mediated by increased activities of NF-kappa B and activating protein-1 and involves activation of the mitogen-activated protein kinase pathways.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(10):5788-97.
2000: Messmer U K; Pfeilschifter J
New insights into the mechanism for clearance of apoptotic cells.
BioEssays : news and reviews in molecular, cellular and developmental biology 2000;22(10):878-81.
2000: Frank S; Stallmeyer B; Kämpfer H; Kolb N; Pfeilschifter J
Leptin enhances wound re-epithelialization and constitutes a direct function of leptin in skin repair.
The Journal of clinical investigation 2000;106(4):501-9.
2000: Wetzler C; Kämpfer H; Stallmeyer B; Pfeilschifter J; Frank S
Large and sustained induction of chemokines during impaired wound healing in the genetically diabetic mouse: prolonged persistence of neutrophils and macrophages during the late phase of repair.
The Journal of investigative dermatology 2000;115(2):245-53.
2000: Wetzler C; Kämpfer H; Pfeilschifter J; Frank S
Keratinocyte-derived chemotactic cytokines: expressional modulation by nitric oxide in vitro and during cutaneous wound repair in vivo.
Biochemical and biophysical research communications 2000;274(3):689-96.
2000: Scholz-Pedretti K; Eberhardt W; Rupprecht G; Beck K F; Spitzer S; Pfeilschifter J; Kaszkin M
Inhibition of NFkappaB-mediated pro-inflammatory gene expression in rat mesangial cells by the enolized 1,3-dioxane-4, 6-dione-5-carboxamide, CGP-43182.
British journal of pharmacology 2000;130(5):1183-90.
2000: Huwiler A; Kolter T; Pfeilschifter J; Sandhoff K
Physiology and pathophysiology of sphingolipid metabolism and signaling.
Biochimica et biophysica acta 2000;1485(2-3):63-99.
2000: Messmer U K; Winkel G; Briner V A; Pfeilschifter J
Suppression of apoptosis by glucocorticoids in glomerular endothelial cells: effects on proapoptotic pathways.
British journal of pharmacology 2000;129(8):1673-83.
2000: Frank S; Kämpfer H; Wetzler C; Stallmeyer B; Pfeilschifter J
Large induction of the chemotactic cytokine RANTES during cutaneous wound repair: a regulatory role for nitric oxide in keratinocyte-derived RANTES expression.
The Biochemical journal 2000;347 Pt 1():265-73.
2000: Walpen S; Beck K F; Eberhardt W; Apel M; Chatterjee P K; Wray G M; Thiemermann C; Pfeilschifter J
Downregulation of SPARC expression is mediated by nitric oxide in rat mesangial cells and during endotoxemia in the rat.
Journal of the American Society of Nephrology : JASN 2000;11(3):468-76.
2000: Frank S; Kämpfer H; Podda M; Kaufmann R; Pfeilschifter J
Identification of copper/zinc superoxide dismutase as a nitric oxide-regulated gene in human (HaCaT) keratinocytes: implications for keratinocyte proliferation.
The Biochemical journal 2000;346 Pt 3():719-28.
2000: Huwiler A; Wartmann M; van den Bosch H; Pfeilschifter J
Extracellular nucleotides activate the p38-stress-activated protein kinase cascade in glomerular mesangial cells.
British journal of pharmacology 2000;129(3):612-8.
2000: Mühl H; Kämpfer H; Bosmann M; Frank S; Radeke H; Pfeilschifter J
Interferon-gamma mediates gene expression of IL-18 binding protein in nonleukocytic cells.
Biochemical and biophysical research communications 2000;267(3):960-3.
2000: Eberhardt W; Beeg T; Beck K F; Walpen S; Gauer S; Böhles H; Pfeilschifter J
Nitric oxide modulates expression of matrix metalloproteinase-9 in rat mesangial cells.
Kidney international 2000;57(1):59-69.
2000: Pfeilschifter J
Signalling pathways of nitric oxide.
Kidney & blood pressure research 2000;23(3-5):159-61.
1999: Stallmeyer B; Kämpfer H; Kolb N; Pfeilschifter J; Frank S
The function of nitric oxide in wound repair: inhibition of inducible nitric oxide-synthase severely impairs wound reepithelialization.
The Journal of investigative dermatology 1999;113(6):1090-8.
1999: Scholz K; Vlachojannis G J; Spitzer S; Schini-Kerth V; Van Den Bosch H; Kaszkin M; Pfeilschifter J
Modulation of cytokine-induced expression of secretory phospholipase A2-type IIA by protein kinase C in rat renal mesangial cells.
Biochemical pharmacology 1999;58(11):1751-8.
1999: Frank S; Stallmeyer B; Kämpfer H; Kolb N; Pfeilschifter J
Nitric oxide triggers enhanced induction of vascular endothelial growth factor expression in cultured keratinocytes (HaCaT) and during cutaneous wound repair.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(14):2002-14.
1999: Mühl H; Nold M; Chang J H; Frank S; Eberhardt W; Pfeilschifter J
Expression and release of chemokines associated with apoptotic cell death in human promonocytic U937 cells and peripheral blood mononuclear cells.
European journal of immunology 1999;29(10):3225-35.
1999: Kämpfer H; Kalina U; Mühl H; Pfeilschifter J; Frank S
Counterregulation of interleukin-18 mRNA and protein expression during cutaneous wound repair in mice.
The Journal of investigative dermatology 1999;113(3):369-74.
1999: Messmer U K; Winkel G; Briner V A; Pfeilschifter J
Glucocorticoids potently block tumour necrosis factor-alpha- and lipopolysaccharide-induced apoptotic cell death in bovine glomerular endothelial cells upstream of caspase 3 activation.
British journal of pharmacology 1999;127(7):1633-40.
1999: Pfeilschifter J; Mühl H
Immunopharmacology: anti-inflammatory therapy targeting transcription factors.
European journal of pharmacology 1999;375(1-3):237-45.
1999: Messmer U K; Briner V A; Pfeilschifter J
Tumor necrosis factor-alpha and lipopolysaccharide induce apoptotic cell death in bovine glomerular endothelial cells.
Kidney international 1999;55(6):2322-37.
1999: Rupprecht G; Scholz K; Beck K F; Geiger H; Pfeilschifter J; Kaszkin M
Cross-talk between group IIA-phospholipase A2 and inducible NO-synthase in rat renal mesangial cells.
British journal of pharmacology 1999;127(1):51-6.
1999: Frank S; Zacharowski K; Wray G M; Thiemermann C; Pfeilschifter J
Identification of copper/zinc superoxide dismutase as a novel nitric oxide-regulated gene in rat glomerular mesangial cells and kidneys of endotoxemic rats.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(8):869-82.
1999: Huwiler A; Dorsch S; Briner V A; van den Bosch H; Pfeilschifter J
Nitric oxide stimulates chronic ceramide formation in glomerular endothelial cells.
Biochemical and biophysical research communications 1999;258(1):60-5.
1999: Huwiler A; Pfeilschifter J; van den Bosch H
Nitric oxide donors induce stress signaling via ceramide formation in rat renal mesangial cells.
The Journal of biological chemistry 1999;274(11):7190-5.
1999: Frank S; Stallmeyer B; Kämpfer H; Schaffner C; Pfeilschifter J
Differential regulation of vascular endothelial growth factor and its receptor fms-like-tyrosine kinase is mediated by nitric oxide in rat renal mesangial cells.
The Biochemical journal 1999;338 ( Pt 2)():367-74.
1999: Huwiler A; Pfeilschifter J
Nitric oxide stimulates the stress-activated protein kinase p38 in rat renal mesangial cells.
The Journal of experimental biology 1999;202(Pt 6):655-60.
1999: Beck K F; Eberhardt W; Frank S; Huwiler A; Messmer U K; Mühl H; Pfeilschifter J
Inducible NO synthase: role in cellular signalling.
The Journal of experimental biology 1999;202(Pt 6):645-53.
1998: Frank S; Kolb N; Werner E R; Pfeilschifter J
Coordinated induction of inducible nitric oxide synthase and GTP-cyclohydrolase I is dependent on inflammatory cytokines and interferon-gamma in HaCaT keratinocytes: implications for the model of cutaneous wound repair.
The Journal of investigative dermatology 1998;111(6):1065-71.
1998: Frank S; Madlener M; Pfeilschifter J; Werner S
Induction of inducible nitric oxide synthase and its corresponding tetrahydrobiopterin-cofactor-synthesizing enzyme GTP-cyclohydrolase I during cutaneous wound repair.
The Journal of investigative dermatology 1998;111(6):1058-64.
1998: Closs E I; Enseleit F; Koesling D; Pfeilschifter J M; Schwarz P M; Förstermann U
Coexpression of inducible NO synthase and soluble guanylyl cyclase in colonic enterocytes: a pathophysiologic signaling pathway for the initiation of diarrhea by gram-negative bacteria?
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1998;12(15):1643-9.
1998: Kaszkin M; Huwiler A; Scholz K; van den Bosch H; Pfeilschifter J
Negative regulation of interleukin-1beta-activated neutral sphingomyelinase by protein kinase C in rat mesangial cells.
FEBS letters 1998;440(1-2):163-6.
1998: Callsen D; Pfeilschifter J; Brüne B
Rapid and delayed p42/p44 mitogen-activated protein kinase activation by nitric oxide: the role of cyclic GMP and tyrosine phosphatase inhibition.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(9):4852-8.
1998: Lapize C; Plüss C; Werner E R; Huwiler A; Pfeilschifter J
Protein kinase C phosphorylates and activates GTP cyclohydrolase I in rat renal mesangial cells.
Biochemical and biophysical research communications 1998;251(3):802-5.
1998: Huwiler A; Fabbro D; Pfeilschifter J
Selective ceramide binding to protein kinase C-alpha and -delta isoenzymes in renal mesangial cells.
Biochemistry 1998;37(41):14556-62.
1998: Beck K F; Eberhardt W; Walpen S; Apel M; Pfeilschifter J
Potentiation of nitric oxide synthase expression by superoxide in interleukin 1 beta-stimulated rat mesangial cells.
FEBS letters 1998;435(1):35-8.
1998: Pfeilschifter J; Huwiler A
Identification of ceramide targets in interleukin-1 and tumor necrosis factor-alpha signaling in mesangial cells.
Kidney international. Supplement 1998;67():S34-9.
1998: Steinmetz M O; Plüss C; Christen U; Wolpensinger B; Lustig A; Werner E R; Wachter H; Engel A; Aebi U; Pfeilschifter J; Kammerer R A
Rat GTP cyclohydrolase I is a homodecameric protein complex containing high-affinity calcium-binding sites.
Journal of molecular biology 1998;279(1):189-99.
1998: Eberhardt W; Plüss C; Hummel R; Pfeilschifter J
Molecular mechanisms of inducible nitric oxide synthase gene expression by IL-1beta and cAMP in rat mesangial cells.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(10):4961-9.
1998: Walker G; Kunz D; Pignat W; Pfeilschifter J
Platelet-derived growth factor and fibroblast growth factor differentially regulate interleukin 1beta- and cAMP-induced group II phospholipase A2 expression in rat renal mesangial cells.
Biochimica et biophysica acta 1998;1391(2):213-22.
1998: Huwiler A; van Rossum G; Wartmann M; Pfeilschifter J
Angiotensin II stimulation of the stress-activated protein kinases in renal mesangial cells is mediated by the angiotensin AT1 receptor subtype.
European journal of pharmacology 1998;343(2-3):297-302.
1998: Sandau K; Pfeilschifter J; Brüne B
Nitrosative and oxidative stress induced heme oxygenase-1 accumulation in rat mesangial cells.
European journal of pharmacology 1998;342(1):77-84.
1997: Kunz D; Walker G; Eberhardt W; Messmer U K; Huwiler A; Pfeilschifter J
Platelet-derived growth factor and fibroblast growth factor differentially regulate interleukin 1beta- and cAMP-induced nitric oxide synthase expression in rat renal mesangial cells.
The Journal of clinical investigation 1997;100(11):2800-9.
1997: Huwiler A; Staudt G; Kramer R M; Pfeilschifter J
Cross-talk between secretory phospholipase A2 and cytosolic phospholipase A2 in rat renal mesangial cells.
Biochimica et biophysica acta 1997;1348(3):257-72.
1997: Plüss C; Werner E R; Wachter H; Pfeilschifter J
Differential effect of dexamethasone on interleukin 1beta- and cyclic AMP-triggered expression of GTP cyclohydrolase I in rat renal mesangial cells.
British journal of pharmacology 1997;122(3):534-8.
1997: Kunz D; Walker G; Pfeilschifter J
Transforming growth factor-beta 2 inhibits interleukin 1 beta-induced expression of inducible nitric oxide synthase in rat renal mesangial cells.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 1997;46(9):327-31.
1997: Sandau K; Pfeilschifter J; Brüne B
Nitric oxide and superoxide induced p53 and Bax accumulation during mesangial cell apoptosis.
Kidney international 1997;52(2):378-86.
1997: Huwiler A; Briner V A; Fabbro D; Pfeilschifter J
Feedback regulation of extracellular ATP-stimulated phosphoinositide hydrolysis by protein kinase C-alpha in bovine glomerular endothelial cells.
Kidney international 1997;52(2):329-37.
1997: Walker G; Kunz D; Pignat W; van den Bosch H; Pfeilschifter J
Suppression by cyclosporin A of interleukin 1 beta-induced expression of group II phospholipase A2 in rat renal mesangial cells.
British journal of pharmacology 1997;121(4):787-93.
1997: Walker G; Pfeilschifter J; Kunz D
Mechanisms of suppression of inducible nitric-oxide synthase (iNOS) expression in interferon (IFN)-gamma-stimulated RAW 264.7 cells by dexamethasone. Evidence for glucocorticoid-induced degradation of iNOS protein by calpain as a key step in post-transcriptional regulation.
The Journal of biological chemistry 1997;272(26):16679-87.
1997: Pfeilschifter J; Huwiler A
Phospholipase A2 in mesangial cells: control mechanisms and functional importance.
Experimental nephrology 1997;5(3):189-93.
1997: Sandau K; Pfeilschifter J; Brüne B
The balance between nitric oxide and superoxide determines apoptotic and necrotic death of rat mesangial cells.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(10):4938-46.
1997: Huwiler A; van Rossum G; Wartmann M; Pfeilschifter J
Stimulation by extracellular ATP and UTP of the stress-activated protein kinase cascade in rat renal mesangial cells.
British journal of pharmacology 1997;120(5):807-12.
1997: Geiges D; Meyer T; Marte B; Vanek M; Weissgerber G; Stabel S; Pfeilschifter J; Fabbro D; Huwiler A
Activation of protein kinase C subtypes alpha, gamma, delta, epsilon, zeta, and eta by tumor-promoting and nontumor-promoting agents.
Biochemical pharmacology 1997;53(6):865-75.
1997: Nitsch D D; Ghilardi N; Mühl H; Nitsch C; Brüne B; Pfeilschifter J
Apoptosis and expression of inducible nitric oxide synthase are mutually exclusive in renal mesangial cells.
The American journal of pathology 1997;150(3):889-900.
1996: Pfeilschifter J; Huwiler A
Regulatory functions of protein kinase C isoenzymes in purinoceptor signalling in mesangial cells.
Journal of autonomic pharmacology 1996;16(6):315-8.
1996: Mühl H; Sandau K; Brüne B; Briner V A; Pfeilschifter J
Nitric oxide donors induce apoptosis in glomerular mesangial cells, epithelial cells and endothelial cells.
European journal of pharmacology 1996;317(1):137-49.
1996: Pfeilschifter J; Huwiler A
Nitric oxide stimulates stress-activated protein kinases in glomerular endothelial and mesangial cells.
FEBS letters 1996;396(1):67-70.
1996: Plüss C; Werner E R; Blau N; Wachter H; Pfeilschifter J
Interleukin 1 beta and cAMP trigger the expression of GTP cyclohydrolase I in rat renal mesangial cells.
The Biochemical journal 1996;318 ( Pt 2)():665-71.
1996: Kunz D; Walker G; Wiesenberg I; Pfeilschifter J
Inhibition by tetranactin of interleukin 1 beta- and cyclic AMP-induced nitric oxide synthase expression in rat renal mesangial cells.
British journal of pharmacology 1996;118(7):1621-6.
1996: Huwiler A; Brunner J; Hummel R; Vervoordeldonk M; Stabel S; van den Bosch H; Pfeilschifter J
Ceramide-binding and activation defines protein kinase c-Raf as a ceramide-activated protein kinase.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(14):6959-63.
1996: Walker G; Kunz D; Pignat W; Wiesenberg I; Van den Bosch H; Pfeilschifter J
Tetranactin inhibits interleukin 1 beta and cAMP induction of group II phospholipase A2 in rat renal mesangial cells.
European journal of pharmacology 1996;306(1-3):265-70.
1996: Eberhardt W; Kunz D; Hummel R; Pfeilschifter J
Molecular cloning of the rat inducible nitric oxide synthase gene promoter.
Biochemical and biophysical research communications 1996;223(3):752-6.
1996: Vervoordeldonk M J; Schalkwijk C G; Pfeilschifter J; van den Bosch H
Effects of dexamethasone and transforming growth factor-beta 2 on group II phospholipase A2 mRNA and activity levels in interleukin 1 beta- and forskolin-stimulated mesangial cells.
The Biochemical journal 1996;315 ( Pt 2)():435-41.
1996: Mühl H; Nitsch D; Sandau K; Brüne B; Varga Z; Pfeilschifter J
Apoptosis is triggered by the cyclic AMP signalling pathway in renal mesangial cells.
FEBS letters 1996;382(3):271-5.
1996: Pfeilschifter J; Eberhardt W; Hummel R; Kunz D; Mühl H; Nitsch D; Plüss C; Walker G
Therapeutic strategies for the inhibition of inducible nitric oxide synthase--potential for a novel class of anti-inflammatory agents.
Cell biology international 1996;20(1):51-8.
1996: Kunz D; Walker G; Eberhardt W; Pfeilschifter J
Molecular mechanisms of dexamethasone inhibition of nitric oxide synthase expression in interleukin 1 beta-stimulated mesangial cells: evidence for the involvement of transcriptional and posttranscriptional regulation.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(1):255-9.
1996: Mühl H; Pfeilschifter J
Amplification of nitric oxide synthase expression by nitric oxide in interleukin 1beta-stimulated rat mesangial cells.
Advances in experimental medicine and biology 1996;387():199-202.
1995: Plüss K M; Pfeilschifter J; Mühl H; Huwiler A; Boeckh C; Otten U
Modulatory role of platelet-derived growth factor on cytokine-induced nerve growth factor synthesis in rat glomerular mesangial cells.
The Biochemical journal 1995;312 ( Pt 3)():707-11.
1995: Kunz D; Walker G; Eberhardt W; Nitsch D; Pfeilschifter J
Interleukin 1 beta-induced expression of nitric oxide synthase in rat renal mesangial cells is suppressed by cyclosporin A.
Biochemical and biophysical research communications 1995;216(2):438-46.
1995: Pfeilschifter J
Does nitric oxide, an inflammatory mediator of glomerular mesangial cells, have a role in diabetic nephropathy?
Kidney international. Supplement 1995;51():S50-60.
1995: Walker G; Kunz D; Pignat W; van den Bosch H; Pfeilschifter J
Pyrrolidine dithiocarbamate differentially affects cytokine- and cAMP-induced expression of group II phospholipase A2 in rat renal mesangial cells.
FEBS letters 1995;364(2):218-22.
1995: Mühl H; Pfeilschifter J
Amplification of nitric oxide synthase expression by nitric oxide in interleukin 1 beta-stimulated rat mesangial cells.
The Journal of clinical investigation 1995;95(4):1941-6.
1995: Huwiler A; Stabel S; Fabbro D; Pfeilschifter J
Platelet-derived growth factor and angiotensin II stimulate the mitogen-activated protein kinase cascade in renal mesangial cells: comparison of hypertrophic and hyperplastic agonists.
The Biochemical journal 1995;305 ( Pt 3)():777-84.
1995: Huwiler A; Fabbro D; Pfeilschifter J
Platelet-derived growth factor stimulates de-novo synthesis of mitogen-activated protein kinase in renal mesangial cells.
European journal of biochemistry / FEBS 1995;227(1-2):209-13.
1995: Pfeilschifter J; Huwiler A; Briner V A
Proliferative mechanisms in kidney cells.
Current opinion in nephrology and hypertension 1995;4(1):98-103.
1994: Huwiler A; Pfeilschifter J
Stimulation by extracellular ATP and UTP of the mitogen-activated protein kinase cascade and proliferation of rat renal mesangial cells.
British journal of pharmacology 1994;113(4):1455-63.
1994: Kunz D; Walker G; Pfeilschifter J
Dexamethasone differentially affects interleukin 1 beta- and cyclic AMP-induced nitric oxide synthase mRNA expression in renal mesangial cells.
The Biochemical journal 1994;304 ( Pt 2)():337-40.
1994: Huwiler A; Pfeilschifter J
Transforming growth factor beta 2 stimulates acute and chronic activation of the mitogen-activated protein kinase cascade in rat renal mesangial cells.
FEBS letters 1994;354(3):255-8.
1994: Mühl H; Pfeilschifter J
Tetrahydrobiopterin is a limiting factor of nitric oxide generation in interleukin 1 beta-stimulated rat glomerular mesangial cells.
Kidney international 1994;46(5):1302-6.
1994: Mühl H; Pfeilschifter J
Possible role of protein kinase C-epsilon isoenzyme in inhibition of interleukin 1 beta induction of nitric oxide synthase in rat renal mesangial cells.
The Biochemical journal 1994;303 ( Pt 2)():607-12.
1994: Huwiler A; Fabbro D; Pfeilschifter J
Comparison of different tumour promoters and bryostatin 1 on protein kinase C activation and down-regulation in rat renal mesangial cells.
Biochemical pharmacology 1994;48(4):689-700.
1994: Huwiler A; Pfeilschifter J
Interleukin-1 stimulates de novo synthesis of mitogen-activated protein kinase in glomerular mesangial cells.
FEBS letters 1994;350(1):135-8.
1994: Kunz D; Mühl H; Walker G; Pfeilschifter J
Two distinct signaling pathways trigger the expression of inducible nitric oxide synthase in rat renal mesangial cells.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(12):5387-91.
1994: Mühl H; Kunz D; Pfeilschifter J
Expression of nitric oxide synthase in rat glomerular mesangial cells mediated by cyclic AMP.
British journal of pharmacology 1994;112(1):1-8.
1994: Eberhardt W; Kunz D; Pfeilschifter J
Pyrrolidine dithiocarbamate differentially affects interleukin 1 beta- and cAMP-induced nitric oxide synthase expression in rat renal mesangial cells.
Biochemical and biophysical research communications 1994;200(1):163-70.
1994: Pfeilschifter J; Kunz D; Mühl H; Eberhardt W
Cytokine regulation of nitric oxide synthase expression in glomerular mesangial cells.
Experimental nephrology 1994;2(2):145.
1993: Pfeilschifter J; Schalkwijk C; Briner V A; van den Bosch H
Cytokine-stimulated secretion of group II phospholipase A2 by rat mesangial cells. Its contribution to arachidonic acid release and prostaglandin synthesis by cultured rat glomerular cells.
The Journal of clinical investigation 1993;92(5):2516-23.
1993: Schalkwijk C G; Vervoordeldonk M; Pfeilschifter J; van den Bosch H
Interleukin-1 beta-induced cytosolic phospholipase A2 activity and protein synthesis is blocked by dexamethasone in rat mesangial cells.
FEBS letters 1993;333(3):339-43.
1993: Mühl H; Kunz D; Rob P; Pfeilschifter J
Cyclosporin derivatives inhibit interleukin 1 beta induction of nitric oxide synthase in renal mesangial cells.
European journal of pharmacology 1993;249(1):95-100.
1993: Pfeilschifter J; Huwiler A
A role for protein kinase C-epsilon in angiotensin II stimulation of phospholipase D in rat renal mesangial cells.
FEBS letters 1993;331(3):267-71.
1993: Pfeilschifter J; Merriweather C
Extracellular ATP and UTP activation of phospholipase D is mediated by protein kinase C-epsilon in rat renal mesangial cells.
British journal of pharmacology 1993;110(2):847-53.
1993: Huwiler A; Pfeilschifter J
A role for protein kinase C-alpha in zymosan-stimulated eicosanoid synthesis in mouse peritoneal macrophages.
European journal of biochemistry / FEBS 1993;217(1):69-75.
1993: Pfeilschifter J; Mühl H; Pignat W; Märki F; van den Bosch H
Cytokine regulation of group II phospholipase A2 expression in glomerular mesangial cells.
European journal of clinical pharmacology 1993;44 Suppl 1():S7-9.
1993: Pfeilschifter J; Kunz D; Mühl H
Nitric oxide: an inflammatory mediator of glomerular mesangial cells.
Nephron 1993;64(4):518-25.
1992: Schalkwijk C G; de Vet E; Pfeilschifter J; van den Bosch H
Interleukin-1 beta and transforming growth factor-beta 2 enhance cytosolic high-molecular-mass phospholipase A2 activity and induce prostaglandin E2 formation in rat mesangial cells.
European journal of biochemistry / FEBS 1992;210(1):169-76.
1992: Schalkwijk C; Pfeilschifter J; Märki F; van den Bosch H
Interleukin-1 beta- and forskolin-induced synthesis and secretion of group II phospholipase A2 and prostaglandin E2 in rat mesangial cells is prevented by transforming growth factor-beta 2.
The Journal of biological chemistry 1992;267(13):8846-51.
1992: Mühl H; Geiger T; Pignat W; Märki F; van den Bosch H; Cerletti N; Cox D; McMaster G; Vosbeck K; Pfeilschifter J
Transforming growth factors type-beta and dexamethasone attenuate group II phospholipase A2 gene expression by interleukin-1 and forskolin in rat mesangial cells.
FEBS letters 1992;301(2):190-4.
1992: Huwiler A; Fabbro D; Stabel S; Pfeilschifter J
Immunocharacterization of delta- and zeta-isoenzymes of protein kinase C in rat renal mesangial cells.
FEBS letters 1992;300(3):259-62.
1992: Pfeilschifter J; Huwiler A; Merriweather C; Briner V A
Angiotensin II stimulation of phospholipase D in rat renal mesangial cells is mediated by the AT1 receptor subtype.
European journal of pharmacology 1992;225(1):57-62.
1992: van den Bosch H; Schalkwijk C; Pfeilschifter J; Märki F
The induction of cellular group II phospholipase A2 by cytokines and its prevention by dexamethasone.
Advances in experimental medicine and biology 1992;318():1-10.
1991: Pfeilschifter J
Platelet-derived growth factor inhibits cytokine induction of nitric oxide synthase in rat renal mesangial cells.
European journal of pharmacology 1991;208(4):339-40.
1991: Steiner P; Pfeilschifter J; Boeckh C; Radeke H; Otten U
Interleukin-1 beta and tumor necrosis factor-alpha synergistically stimulate nerve growth factor synthesis in rat mesangial cells.
The American journal of physiology 1991;261(5 Pt 2):F792-8.
1991: Mühl H; Geiger T; Pignat W; Märki F; van den Bosch H; Vosbeck K; Pfeilschifter J
PDGF suppresses the activation of group II phospholipase A2 gene expression by interleukin 1 and forskolin in mesangial cells.
FEBS letters 1991;291(2):249-52.
1991: Schalkwijk C; Vervoordeldonk M; Pfeilschifter J; Märki F; van den Bosch H
Cytokine- and forskolin-induced synthesis of group II phospholipase A2 and prostaglandin E2 in rat mesangial cells is prevented by dexamethasone.
Biochemical and biophysical research communications 1991;180(1):46-52.
1991: Huwiler A; Fabbro D; Pfeilschifter J
Possible regulatory functions of protein kinase C-alpha and -epsilon isoenzymes in rat renal mesangial cells. Stimulation of prostaglandin synthesis and feedback inhibition of angiotensin II-stimulated phosphoinositide hydrolysis.
The Biochemical journal 1991;279 ( Pt 2)():441-5.
1991: Wiesenberg-Boettcher I; Pfeilschifter J; Schweizer A; Sallmann A; Wenk P
Pharmacological properties of five diclofenac metabolites identified in human plasma.
Agents and actions 1991;34(1-2):135-7.
1991: Schalkwijk C; Pfeilschifter J; Märki F; van den Bosch H
Interleukin-1 beta, tumor necrosis factor and forskolin stimulate the synthesis and secretion of group II phospholipase A2 in rat mesangial cells.
Biochemical and biophysical research communications 1991;174(1):268-75.
1991: Pfeilschifter J; Leighton J; Pignat W; Märki F; Vosbeck K
Cyclic AMP mimics, but does not mediate, interleukin-1- and tumour-necrosis-factor-stimulated phospholipase A2 secretion from rat renal mesangial cells.
The Biochemical journal 1991;273(Pt 1)():199-204.
1991: Pfeilschifter J; Hosang M
Effects of homo- and heterodimeric isoforms of PDGF on signalling events in rat renal mesangial cells.
Cellular signalling 1991;3(5):413-24.
1990: Pfeilschifter J
Comparison of extracellular ATP and UTP signalling in rat renal mesangial cells. No indications for the involvement of separate purino- and pyrimidino-ceptors.
The Biochemical journal 1990;272(2):469-72.
1990: Pfeilschifter J; Pignat W; Leighton J; Märki F; Vosbeck K; Alkan S
Transforming growth factor beta 2 differentially modulates interleukin-1 beta- and tumour-necrosis-factor-alpha-stimulated phospholipase A2 and prostaglandin E2 synthesis in rat renal mesangial cells.
The Biochemical journal 1990;270(1):269-71.
1990: Pfeilschifter J
Angiotensin II B-type receptor mediates phosphoinositide hydrolysis in mesangial cells.
European journal of pharmacology 1990;184(1):201-2.
1990: Pfeilschifter J; Mühl H
Interleukin 1 and tumor necrosis factor potentiate angiotensin II- and calcium ionophore-stimulated prostaglandin E2 synthesis in rat renal mesangial cells.
Biochemical and biophysical research communications 1990;169(2):585-95.
1990: Märki F; Pfeilschifter J; Rink H; Wiesenberg I
'Antiflammins': two nonapeptide fragments of uteroglobin and lipocortin I have no phospholipase A2-inhibitory and anti-inflammatory activity.
FEBS letters 1990;264(2):171-5.
1989: Pfeilschifter J; Pignat W; Märki F; Wiesenberg I
Release of phospholipase A2 activity from rat vascular smooth muscle cells mediated by cAMP.
European journal of biochemistry / FEBS 1989;181(1):237-42.
1989: Pfeilschifter J; Pignat W; Vosbeck K; Märki F
Interleukin 1 and tumor necrosis factor synergistically stimulate prostaglandin synthesis and phospholipase A2 release from rat renal mesangial cells.
Biochemical and biophysical research communications 1989;159(2):385-94.
1989: Wiesenberg-Boettcher I; Schweizer A; Green J R; Mueller K; Maerki F; Pfeilschifter J
The pharmacological profile of CGP 28238, a novel highly potent anti-inflammatory compound.
Drugs under experimental and clinical research 1989;15(11-12):501-9.

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