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David Phelps

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Wesley M Konsavage; David S Phelps; Todd M Umstead; Yuchieh Wu; Jeffrey S Shenberger
Hyperoxia-induced alterations in the pulmonary proteome of juvenile rats.
Colin MacNeill; David S Phelps; Grace E Sousa; Todd M Umstead; Kwangmi Ahn; Glendell de Guzman; Joanna Floros; Judith Weisz
Cyclic changes in the level of the innate immune molecule, surfactant protein-a, and cytokines in vaginal fluid.
Faryal Durrani; Sanmei Hu; Anatoly N Mikerov; David S Phelps; Patricia Silveyra; Judith Weisz; Joanna Floros
Gonadal hormones and oxidative stress interaction differentially affects survival of male and female mice after lung Klebsiella pneumoniae infection.

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All Publications

2013: Wesley M Konsavage; David S Phelps; Todd M Umstead; Yuchieh Wu; Jeffrey S Shenberger
Hyperoxia-induced alterations in the pulmonary proteome of juvenile rats.
Experimental lung research 2013;39(2):107-17.
2012: Colin MacNeill; David S Phelps; Grace E Sousa; Todd M Umstead; Kwangmi Ahn; Glendell de Guzman; Joanna Floros; Judith Weisz
Cyclic changes in the level of the innate immune molecule, surfactant protein-a, and cytokines in vaginal fluid.
American journal of reproductive immunology (New York, N.Y. : 1989) 2012;68(3):244-50.
2012: Faryal Durrani; Sanmei Hu; Anatoly N Mikerov; David S Phelps; Patricia Silveyra; Judith Weisz; Joanna Floros
Gonadal hormones and oxidative stress interaction differentially affects survival of male and female mice after lung Klebsiella pneumoniae infection.
Experimental lung research 2012;38(4):165-72.
2012: Anatoly N Mikerov; David S Phelps; Todd M Umstead; Guirong Wang; Faryal Durrani; Xiaozhuang Gan; Sanmei Hu; Joanna Floros
Impact of sex and ozone exposure on the course of pneumonia in wild type and SP-A (-/-) mice.
Microbial pathogenesis 2012;52(4):239-49.
2012: David S Phelps; Todd M Umstead; Joanna Floros
Sex differences in the response of the alveolar macrophage proteome to treatment with exogenous surfactant protein-A.
Proteome science 2012;10(1):44.
2012: Todd M Umstead; Akif Undar; Neal J Thomas; Vernon M Chinchilli; J Brian Clark; Willard M Freeman; Nikolina Icitovic; Chia-jung K Lu; John L Myers; David S Phelps
The kinetics of cardiopulmonary bypass: a dual-platform proteomics study of plasma biomarkers in pediatric patients undergoing cardiopulmonary bypass.
Artificial organs 2012;36(1):E1-20.
2011: Anatoly N Mikerov; David S Phelps; Todd M Umstead; Guirong Wang; Timothy K Cooper; Sanmei Hu; Joanna Floros
Histopathologic evaluation of lung and extrapulmonary tissues show sex differences in Klebsiella pneumoniae - infected mice under different exposure conditions.
International journal of physiology, pathophysiology and pharmacology 2011;3(3):176-90.
2011: David S Phelps; Omar A Quintero; Todd M Umstead; Christopher M Yengo; Joanna Floros
In vivo rescue of alveolar macrophages from SP-A knockout mice with exogenous SP-A nearly restores a wild type intracellular proteome; actin involvement.
Proteome science 2011;9():67.
2010: Todd M Umstead; Chia-Jung K Lu; Willard M Freeman; John L Myers; J Brian Clark; Neal J Thomas; Vernon M Chinchilli; Kent Vrana; Akif Undar; David S Phelps
Dual-platform proteomics study of plasma biomarkers in pediatric patients undergoing cardiopulmonary bypass.
Pediatric research 2010;67(6):641-9.
2010: Mehboob Ali; Todd M Umstead; Rizwanul Haque; Anatoly N Mikerov; Willard M Freeman; Joanna Floros; David S Phelps
Differences in the BAL proteome after Klebsiella pneumoniae infection in wild type and SP-A-/- mice.
Proteome science 2010;8():34.
2008: Jelena Pavlovic; Joanna Floros; David S Phelps; Brian Wigdahl; Patricia Welsh; Judith Weisz; Debra A Shearer; Alphonse Leure du Pree; Roland Myers; Mary K Howett
Differentiation of xenografted human fetal lung parenchyma.
Early human development 2008;84(3):181-93.
2008: Anatoly N Mikerov; Rizwanul Haque; Xiaozhuang Gan; Xiaoxuan Guo; David S Phelps; Joanna Floros
Ablation of SP-A has a negative impact on the susceptibility of mice to Klebsiella pneumoniae infection after ozone exposure: sex differences.
Respiratory research 2008;9():77.
2008: Anatoly N Mikerov; Xiaozhuang Gan; Todd M Umstead; Laura Miller; Vernon M Chinchilli; David S Phelps; Joanna Floros
Sex differences in the impact of ozone on survival and alveolar macrophage function of mice after Klebsiella pneumoniae infection.
Respiratory research 2008;9():24.
2008: Anatoly N Mikerov; Todd M Umstead; Xiaozhuang Gan; Weixiong Huang; Xiaoxuan Guo; Guirong Wang; David S Phelps; Joanna Floros
Impact of ozone exposure on the phagocytic activity of human surfactant protein A (SP-A) and SP-A variants.
American journal of physiology. Lung cellular and molecular physiology 2008;294(1):L121-30.
2007: Hephzibah Rani S Tagaram; Guirong Wang; Todd M Umstead; Anatoly N Mikerov; Neal J Thomas; Gavin R Graff; Joseph C Hess; Mary Jane Thomassen; mani kavuru; David S Phelps; Joanna Floros
Characterization of a human surfactant protein A1 (SP-A1) gene-specific antibody; SP-A1 content variation among individuals of varying age and pulmonary health.
American journal of physiology. Lung cellular and molecular physiology 2007;292(5):L1052-63.
2007: Rizwanul Haque; Todd M Umstead; Padmavathi Ponnuru; Xiaoxuan Guo; Samuel Hawgood; David S Phelps; Joanna Floros
Role of surfactant protein-A (SP-A) in lung injury in response to acute ozone exposure of SP-A deficient mice.
Toxicology and applied pharmacology 2007;220(1):72-82.
2007: Demetrios Stagos; Todd M Umstead; David S Phelps; Leandros Skaltsounis; Serkos A Haroutounian; Joanna Floros; Demetrios Kouretas
Inhibition of ozone-induced SP-A oxidation by plant polyphenols.
Free radical research 2007;41(3):357-66.
2007: Anatoly N Mikerov; Guirong Wang; Todd M Umstead; Mario Zacharatos; Neal J Thomas; David S Phelps; Joanna Floros
Surfactant protein A2 (SP-A2) variants expressed in CHO cells stimulate phagocytosis of Pseudomonas aeruginosa more than do SP-A1 variants.
Infection and immunity 2007;75(3):1403-12.
2005: Neal J Thomas; Todd M Umstead; David S Phelps
Altered chemokine response in an animal model of multiple organ dysfunction syndrome induced by zymosan.
Journal of pediatric surgery 2005;40(3):464-9.
2005: Branislava Janic; Todd M Umstead; David S Phelps; Joanna Floros
Modulatory effects of ozone on THP-1 cells in response to SP-A stimulation.
American journal of physiology. Lung cellular and molecular physiology 2005;288(2):L317-25.
2005: Anatoly N Mikerov; Todd M Umstead; Weixiong Huang; Wenlei Liu; David S Phelps; Joanna Floros
SP-A1 and SP-A2 variants differentially enhance association of Pseudomonas aeruginosa with rat alveolar macrophages.
American journal of physiology. Lung cellular and molecular physiology 2005;288(1):L150-8.
2004: Jianqiang Ding; Todd M Umstead; Joanna Floros; David S Phelps
Factors affecting SP-A-mediated phagocytosis in human monocytic cell lines.
Respiratory medicine 2004;98(7):637-50.
2004: Guirong Wang; Sandra R Bates-Kenney; Jian-Qin Tao; David S Phelps; Joanna Floros
Differences in biochemical properties and in biological function between human SP-A1 and SP-A2 variants, and the impact of ozone-induced oxidation.
Biochemistry 2004;43(14):4227-39.
2004: Weixiong Huang; Guirong Wang; David S Phelps; Hamid Al-Mondhiry; Joanna Floros
Human SP-A genetic variants and bleomycin-induced cytokine production by THP-1 cells: effect of ozone-induced SP-A oxidation.
American journal of physiology. Lung cellular and molecular physiology 2004;286(3):L546-53.
2004: David S Phelps; Todd M Umstead; Mayra Mejia; Guillermo Carrillo; Annie Pardo; Moisés Selman
Increased surfactant protein-A levels in patients with newly diagnosed idiopathic pulmonary fibrosis.
Chest 2004;125(2):617-25.
2004: Colin MacNeill; Todd M Umstead; David S Phelps; Zhenwu Lin; Joanna Floros; Debra A Shearer; Judith Weisz
Surfactant protein A, an innate immune factor, is expressed in the vaginal mucosa and is present in vaginal lavage fluid.
Immunology 2004;111(1):91-9.
2003: Moisés Selman; Hung-Mo Lin; Martha Montaño; Audrey L Jenkins; Andrea Estrada; Zhenwu Lin; Guirong Wang; Susan DiAngelo; Xiaoxuan Guo; Todd M Umstead; C Max Lang; Annie Pardo; David S Phelps; Joanna Floros
Surfactant protein A and B genetic variants predispose to idiopathic pulmonary fibrosis.
Human genetics 2003;113(6):542-50.
2003: Luis G Vazquez de Lara; Todd M Umstead; Sara E Davis; David S Phelps
Surfactant protein A increases matrix metalloproteinase-9 production by THP-1 cells.
American journal of physiology. Lung cellular and molecular physiology 2003;285(4):L899-906.
2003: Branislava Janic; Todd M Umstead; David S Phelps; Joanna Floros
An in vitro cell model system for the study of the effects of ozone and other gaseous agents on phagocytic cells.
Journal of immunological methods 2003;272(1-2):125-34.
2002: Weixiong Huang; Guirong Wang; David S Phelps; Hamid Al-Mondhiry; Joanna Floros
Combined SP-A-bleomycin effect on cytokines by THP-1 cells: impact of surfactant lipids on this effect.
American journal of physiology. Lung cellular and molecular physiology 2002;283(1):L94-L102.
2002: Todd M Umstead; David S Phelps; Guirong Wang; Joanna Floros; Brian K Tarkington
In vitro exposure of proteins to ozone.
Toxicology mechanisms and methods 2002;12(1):1-16.
2002: Guirong Wang; Todd M Umstead; David S Phelps; Hamid Al-Mondhiry; Joanna Floros
The effect of ozone exposure on the ability of human surfactant protein a variants to stimulate cytokine production.
Environmental health perspectives 2002;110(1):79-84.
2001: Zhenwu Lin; Daphne E Demello; David S Phelps; Walter A Koltun; M Page; Joanna Floros
Both human SP-A1 and Sp-A2 genes are expressed in small and large intestine.
Pediatric pathology & molecular medicine 2001;20(5):367-86.
2001: David S Phelps
Surfactant regulation of host defense function in the lung: a question of balance.
Pediatric pathology & molecular medicine 2001;20(4):269-92.
2000: M Song; David S Phelps
Interaction of surfactant protein A with lipopolysaccharide and regulation of inflammatory cytokines in the THP-1 monocytic cell line.
Infection and immunity 2000;68(12):6611-7.
2000: L Vázquez de Lara; Carina Becerril; Martha Montaño; Carlos Ramos; Vilma Maldonado; J Meléndez; David S Phelps; Annie Pardo; Moisés Selman
Surfactant components modulate fibroblast apoptosis and type I collagen and collagenase-1 expression.
American journal of physiology. Lung cellular and molecular physiology 2000;279(5):L950-7.
2000: M Song; David S Phelps
Comparison of SP-A and LPS effects on the THP-1 monocytic cell line.
American journal of physiology. Lung cellular and molecular physiology 2000;279(1):L110-7.
2000: Guirong Wang; David S Phelps; Todd M Umstead; Joanna Floros
Human SP-A protein variants derived from one or both genes stimulate TNF-alpha production in the THP-1 cell line.
American journal of physiology. Lung cellular and molecular physiology 2000;278(5):L946-54.
1997: M Koptides; Todd M Umstead; Joanna Floros; David S Phelps
Surfactant protein A activates NF-kappa B in the THP-1 monocytic cell line.
The American journal of physiology 1997;273(2 Pt 1):L382-8.
1997: S G Kremlev; David S Phelps
Effect of SP-A and surfactant lipids on expression of cell surface markers in the THP-1 monocytic cell line.
The American journal of physiology 1997;272(6 Pt 1):L1070-7.
1997: S G Kremlev; Todd M Umstead; David S Phelps
Surfactant protein A regulates cytokine production in the monocytic cell line THP-1.
The American journal of physiology 1997;272(5 Pt 1):L996-1004.
1996: David S Phelps; Todd M Umstead; R M Rose; Jay A Fishman
Surfactant protein-A levels increase during Pneumocystis carinii pneumonia in the rat.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1996;9(3):565-70.
1996: B B Moglia; David S Phelps
Changes in surfactant protein A mRNA levels in a rat model of insulin-treated diabetic pregnancy.
Pediatric research 1996;39(2):241-7.
1994: S G Kremlev; David S Phelps
Surfactant protein A stimulation of inflammatory cytokine and immunoglobulin production.
The American journal of physiology 1994;267(6 Pt 1):L712-9.
1994: S G Kremlev; Todd M Umstead; David S Phelps
Effects of surfactant protein A and surfactant lipids on lymphocyte proliferation in vitro.
The American journal of physiology 1994;267(4 Pt 1):L357-64.
1994: Daphne E Demello; S Heyman; David S Phelps; Aaron Hamvas; Lawrence M Nogee; S Cole; HR Colten
Ultrastructure of lung in surfactant protein B deficiency.
American journal of respiratory cell and molecular biology 1994;11(2):230-9.
1993: Seamus A Rooney; Laurice I Gobran; Todd M Umstead; David S Phelps
Secretion of surfactant protein A from rat type II pneumocytes.
The American journal of physiology 1993;265(6 Pt 1):L586-90.
1993: Daphne E Demello; S Heyman; David S Phelps; Joanna Floros
Immunogold localization of SP-A in lungs of infants dying from respiratory distress syndrome.
The American journal of pathology 1993;142(5):1631-40.
1992: S H Guttentag; David S Phelps; J B Warshaw; Joanna Floros
Delayed hydrophobic surfactant protein (SP-B, SP-C) expression in fetuses of streptozotocin-treated rats.
American journal of respiratory cell and molecular biology 1992;7(2):190-7.
1992: S H Guttentag; David S Phelps; Joanna Floros
Surfactant protein regulation and diabetic pregnancy.
Seminars in perinatology 1992;16(2):122-9.
1992: S H Guttentag; David S Phelps; W Stenzel; J B Warshaw; Joanna Floros
Surfactant protein A expression is delayed in fetuses of streptozotocin-treated rats.
The American journal of physiology 1992;262(4 Pt 1):L489-94.
1991: David S Phelps; Joanna Floros
Localization of pulmonary surfactant proteins using immunohistochemistry and tissue in situ hybridization.
Experimental lung research 1991;17(6):985-95.
1991: S Chida; David S Phelps; Roger F Soll; H W Taeusch
Surfactant proteins and anti-surfactant antibodies in sera from infants with respiratory distress syndrome with and without surfactant treatment.
Pediatrics 1991;88(1):84-9.
1991: David S Phelps; R M Rose
Increased recovery of surfactant protein A in AIDS-related pneumonia.
The American review of respiratory disease 1991;143(5 Pt 1):1072-5.
1991: David S Phelps; Joanna Floros
Dexamethasone in vivo raises surfactant protein B mRNA in alveolar and bronchiolar epithelium.
The American journal of physiology 1991;260(2 Pt 1):L146-52.
1991: Joanna Floros; David S Phelps; Daphne E Demello; J Longmate; H Harding; B Benson; T White
The utility of postmortem lung for RNA studies; variability and correlation of the expression of surfactant proteins in human lung.
Experimental lung research 1991;17(1):91-104.
1989: Joanna Floros; David S Phelps; H P Harding; S Church; J Ware
Postnatal stimulation of rat surfactant protein A synthesis by dexamethasone.
The American journal of physiology 1989;257(2 Pt 1):L137-43.
1989: Daphne E Demello; David S Phelps; G Patel; Joanna Floros; D Lagunoff
Expression of the 35kDa and low molecular weight surfactant-associated proteins in the lungs of infants dying with respiratory distress syndrome.
The American journal of pathology 1989;134(6):1285-93.
1989: A Charon; W Taeusch; C Fitzgibbon; G B Smith; S Ted Treves; David S Phelps
Factors associated with surfactant treatment response in infants with severe respiratory distress syndrome.
Pediatrics 1989;83(3):348-54.
1988: G B Smith; H W Taeusch; David S Phelps; Kevin M W Keough
Mixtures of low molecular weight surfactant proteins and dipalmitoyl phosphatidylcholine duplicate effects of pulmonary surfactant in vitro and in vivo.
Pediatric research 1988;23(5):484-90.
1988: David S Phelps; Joanna Floros
Proline hydroxylation alters the electrophoretic mobility of pulmonary surfactant-associated protein A.
Electrophoresis 1988;9(5):231-3.
1988: S Chida; David S Phelps; C Cordle; Roger F Soll; Joanna Floros; H W Taeusch
Surfactant-associated proteins in tracheal aspirates of infants with respiratory distress syndrome after surfactant therapy.
The American review of respiratory disease 1988;137(4):943-7.
1988: David S Phelps; Joanna Floros
Localization of surfactant protein synthesis in human lung by in situ hybridization.
The American review of respiratory disease 1988;137(4):939-42.
1987: David S Phelps; H P Harding
Immunohistochemical localization of a low molecular weight surfactant-associated protein in human lung.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1987;35(11):1339-42.
1987: Kenneth A Jacobs; David S Phelps; R Steinbrink; J Fisch; Ron Kriz; L Mitsock; J P Dougherty; H W Taeusch; Joanna Floros
Isolation of a cDNA clone encoding a high molecular weight precursor to a 6-kDa pulmonary surfactant-associated protein.
The Journal of biological chemistry 1987;262(20):9808-11.
1987: David S Phelps; L M Smith; H W Taeusch
Characterization and partial amino acid sequence of a low molecular weight surfactant protein.
The American review of respiratory disease 1987;135(5):1112-7.
1986: David S Phelps; Joanna Floros; H W Taeusch
Post-translational modification of the major human surfactant-associated proteins.
The Biochemical journal 1986;237(2):373-7.
1986: Joanna Floros; David S Phelps; S Kourembanas; H W Taeusch
Primary translation products, biosynthesis, and tissue specificity of the major surfactant protein in rat.
The Journal of biological chemistry 1986;261(2):828-31.
1985: Joanna Floros; David S Phelps; H W Taeusch
Biosynthesis and in vitro translation of the major surfactant-associated protein from human lung.
The Journal of biological chemistry 1985;260(1):495-500.
1985: David S Phelps; H W Taeusch
A comparison of the major surfactant-associated proteins in different species.
Comparative biochemistry and physiology. B, Comparative biochemistry 1985;82(3):441-6.
1984: David S Phelps; H W Taeusch; B Benson; Samuel Hawgood
An electrophoretic and immunochemical characterization of human surfactant-associated proteins.
Biochimica et biophysica acta 1984;791(2):226-38.