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Mitch Phelps

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Amir Mortazavi; Gregory A Otterson; Mitch A Phelps; Lai Wei; Xin Wu; Yun Yen; Bing-Sen Zhou; Deidre Deam; Michael R Grever; Erica J Harper; William J Hicks; S Percy Ivy; Yonghua Ling; Xiyong Liu; Zhongfa Liu; Ludmila Katherine Martin; J Paul Monk; Tanios Bekaii-Saab
A phase I study of prolonged infusion of triapine in combination with fixed dose rate gemcitabine in patients with advanced solid tumors.
Chenguang Zhou; L James Lee; Mitch A Phelps; Bo Yu; Yue Zhang; Robert J Lee
Comparative cellular pharmacokinetics and pharmacodynamics of siRNA delivery by SPANosomes and by cationic liposomes.
Jia Ji; Amy J Johnson; Diane R Mould; Kristie A Blum; John C Byrd; Michael R Grever; Ming Poi; Amy S Ruppert; Yuan Zhao; Mitch A Phelps
A pharmacokinetic/pharmacodynamic model of tumor lysis syndrome in chronic lymphocytic leukemia patients treated with flavopiridol.

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2013: Amir Mortazavi; Gregory A Otterson; Mitch A Phelps; Lai Wei; Xin Wu; Yun Yen; Bing-Sen Zhou; Deidre Deam; Michael R Grever; Erica J Harper; William J Hicks; S Percy Ivy; Yonghua Ling; Xiyong Liu; Zhongfa Liu; Ludmila Katherine Martin; J Paul Monk; Tanios Bekaii-Saab
A phase I study of prolonged infusion of triapine in combination with fixed dose rate gemcitabine in patients with advanced solid tumors.
Investigational new drugs 2013;31(3):685-95.
2013: Chenguang Zhou; L James Lee; Mitch A Phelps; Bo Yu; Yue Zhang; Robert J Lee
Comparative cellular pharmacokinetics and pharmacodynamics of siRNA delivery by SPANosomes and by cationic liposomes.
Nanomedicine : nanotechnology, biology, and medicine 2013;9(4):504-13.
2013: Jia Ji; Amy J Johnson; Diane R Mould; Kristie A Blum; John C Byrd; Michael R Grever; Ming Poi; Amy S Ruppert; Yuan Zhao; Mitch A Phelps
A pharmacokinetic/pharmacodynamic model of tumor lysis syndrome in chronic lymphocytic leukemia patients treated with flavopiridol.
Clinical cancer research : an official journal of the American Association for Cancer Research 2013;19(5):1269-80.
2012: Ronald A Spatola; Mirunalni Thangavelu; Vijayasaradhi Upadhyayula; Seungsoo Lee; Mitch A Phelps; Heather L Chandler
Analysis of the transport of and cytotoxic effects for nalbuphine solution in corneal cells.
American journal of veterinary research 2012;73(12):1987-95.
2012: Darlene M Rozewski; Jungook D Shin; Matthew R Stefanovski; William H Towns; Xiaoxia Yang; John C Byrd; Yue Gao; Sarah Elizabeth May Herman; David Jarjoura; Amy J Johnson; Xiaobai Li; Emilia Mahoney; Mitch A Phelps
Pharmacokinetics and tissue disposition of lenalidomide in mice.
The AAPS journal 2012;14(4):872-82.
2012: Mathew George; Mitch A Phelps; Joseph P Kitzmiller
Acetaminophen pediatric dose selection: caregiver satisfaction regarding the antipyretic efficacy of acetaminophen in children.
Clinical pediatrics 2012;51(11):1030-1.
2012: Lei He; Kari Kendra; Yonghua Ling; Mani Matharbootham; Nina Mayr; John McGregor; Ewa Mrozek; Thomas Olencki; Chima Oluigbo; Mario Ammirati; Robert Cavaliere; Michael D Enzerra; John C Grecula; Mitch A Phelps
Development and validation of sensitive liquid chromatography/tandem mass spectrometry method for quantification of bendamustine in mouse brain tissue.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2012;905():141-4.
2012: Maria I Menéndez; Mitch A Phelps; Elijah A Hothem; Alicia L Bertone
Pharmacokinetics of methylprednisolone acetate after intra-articular administration and subsequent suppression of endogenous hydrocortisone secretion in exercising horses.
American journal of veterinary research 2012;73(9):1453-61.
2012: Joseph P Kitzmiller; Kandamurugu Manickam; Clay B Marsh; Mitch A Phelps; Peter Joseph Embi; Rebecca D Jackson; Kevin M Sweet; Wolfgang Sadee
Program in pharmacogenomics at the Ohio State University Medical Center.
Pharmacogenomics 2012;13(7):751-6.
2012: Bhuvaneswari Ramaswamy; Lai Wei; Deidre Wilkins; Anna Wolfson; Daria Arbogast; Robert Baiocchi; Tanios Bekaii-Saab; John C Byrd; Angela Campbell; Austin Doyle; Michael R Grever; Ju-Ping Lai; Mark E Lustberg; Wenjun Ni; Mitch A Phelps; Manisha H Shah
A dose-finding, pharmacokinetic and pharmacodynamic study of a novel schedule of flavopiridol in patients with advanced solid tumors.
Investigational new drugs 2012;30(2):629-38.
2012: Jennifer A Dulin; Maria I Menendez; Mitch A Phelps; EM Santschi; W Tod Drost; Alicia L Bertone
Influence of exercise on the distribution of technetium Tc 99m medronate following intra-articular injection in horses.
American journal of veterinary research 2012;73(3):418-25.
2012: Deborah M Stephens; Kristie Blum; Joseph M Flynn; Michael R Grever; Jia Ji; Amy J Johnson; Jeffrey Jones; Mitch A Phelps; Amy S Ruppert; John C Byrd
Flavopiridol treatment of patients aged 70 or older with refractory or relapsed chronic lymphocytic leukemia is a feasible and active therapeutic approach.
Haematologica 2012;97(3):423-7.
2011: Craig C Hofmeister; Jia Ji; Amy J Johnson; Eric H Kraut; Seungsoo Lee; Zhongfa Liu; Flavia Pichiorri; Darlene M Rozewski; Larry J Schaaf; Xiaoxia Yang; Don M Benson; John C Byrd; Kenneth K Chan; Ching-Shih Chen; Ping Chen; Sherif S Farag; Celia L Garr; Michael R Grever; Erinn M Hade; William J Hicks; Mitch A Phelps
Phase I trial of lenalidomide and CCI-779 in patients with relapsed multiple myeloma: evidence for lenalidomide-CCI-779 interaction via P-glycoprotein.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2011;29(25):3427-34.
2011: Sneha V Gupta; Nyla A Heerema; David Jarjoura; A Douglas Kinghorn; Amy Lehman; Gerard Lozanski; John C Byrd; Kenneth K Chan; Melanie E Davis; Ryan B Edwards; Michael R Grever; Li Pan; Mitch A Phelps; Ellen J Sass; Xiaoli Zhang; David M Lucas
Resistance to the translation initiation inhibitor silvestrol is mediated by ABCB1/P-glycoprotein overexpression in acute lymphoblastic leukemia cells.
The AAPS journal 2011;13(3):357-64.
2011: U V R Vijaya Saradhi; Jiang Wang; Ming Chiu; Joseph M Covey; Michael R Grever; Sneha V Gupta; A Douglas Kinghorn; Yonghua Ling; Zhongfa Liu; David M Lucas; Guido Marcucci; David J Newman; Mitch A Phelps; Kenneth K Chan
Characterization of silvestrol pharmacokinetics in mice using liquid chromatography-tandem mass spectrometry.
The AAPS journal 2011;13(3):347-56.
2011: Tanios Bekaii-Saab; Mark Bloomston; L Austin Doyle; Gilian Ellison; Laura Goff; Michael Grever; John Sae Wook Kauh; Xiaobai Li; Ryan Liersemann; William Marsh; Bert O Neil; Mitch A Phelps; Matthew D Ringel; Motoyasu Saji; Vasily V Vasko; Catherine Balint; Stephanie Balsom; Miguel A Villalona-Calero
Multi-institutional phase II study of selumetinib in patients with metastatic biliary cancers.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2011;29(17):2357-63.
2011: Joseph P Kitzmiller; David K Groen; Mitch A Phelps; Wolfgang Sadee
Pharmacogenomic testing: relevance in medical practice: why drugs work in some patients but not in others.
Cleveland Clinic journal of medicine 2011;78(4):243-57.
2010: William Blum; Rebecca B Klisovic; Heiko Becker; Xiaoxia Yang; Darlene M Rozewski; Mitch A Phelps; Ramiro Garzon; Alison Walker; Jason C Chandler; Susan P Whitman; John Curfman; Shujun Liu; Larry J Schaaf; Jon Mickle; Cheryl Kefauver; Steven M Devine; Michael R Grever; Guido Marcucci; John C Byrd
Dose escalation of lenalidomide in relapsed or refractory acute leukemias.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010;28(33):4919-25.
2010: William Blum; Mitch A Phelps; Rebecca B Klisovic; Darlene M Rozewski; Wenjun Ni; Katie A Albanese; Brad H Rovin; Cheryl Kefauver; Steven M Devine; David M Lucas; Amy Johnson; Larry J Schaaf; John C Byrd; Guido Marcucci; Michael R Grever
Phase I clinical and pharmacokinetic study of a novel schedule of flavopiridol in relapsed or refractory acute leukemias.
Haematologica 2010;95(7):1098-105.
2010: Wenjun Ni; Jia Ji; Zunyan Dai; Audrey Papp; Amy J Johnson; Sunjoo Ahn; Katherine L Farley; Thomas S Lin; James T Dalton; Xiaobai Li; David Jarjoura; John C Byrd; Wolfgang Sadee; Michael R Grever; Mitch A Phelps
Flavopiridol pharmacogenetics: clinical and functional evidence for the role of SLCO1B1/OATP1B1 in flavopiridol disposition.
PloS one 2010;5(11):e13792.
2009: Thomas S Lin; Amy S Ruppert; Amy J Johnson; Beth Fischer; Nyla A Heerema; Leslie A Andritsos; Kristie A Blum; Joseph M Flynn; Jeffrey A Jones; Weihong Hu; Mollie E Moran; Sarah M Mitchell; Lisa L Smith; Amy J Wagner; Chelsey A Raymond; Larry J Schaaf; Mitch A Phelps; Miguel A Villalona-Calero; Michael R Grever; John C Byrd
Phase II study of flavopiridol in relapsed chronic lymphocytic leukemia demonstrating high response rates in genetically high-risk disease.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(35):6012-8.
2009: Thomas S Lin; Wendy Stock; Huiping Xu; Mitch A Phelps; Margaret S Lucas; Sara K Guster; Bruce R Briggs; Carolyn M Cheney; Pierluigi Porcu; Ian W Flinn; Michael R Grever; James T Dalton; John C Byrd
A phase I/II dose escalation study of apolizumab (Hu1D10) using a stepped-up dosing schedule in patients with chronic lymphocytic leukemia and acute leukemia.
Leukemia & lymphoma 2009;50(12):1958-63.
2009: Mitch A Phelps; Thomas S Lin; Amy J Johnson; Eunju Hurh; Darlene M Rozewski; Katherine L Farley; Di Wu; Kristie A Blum; Beth Fischer; Sarah M Mitchell; Mollie E Moran; Michelle Brooker-McEldowney; Nyla A Heerema; David Jarjoura; Larry J Schaaf; John C Byrd; Michael R Grever; James T Dalton
Clinical response and pharmacokinetics from a phase 1 study of an active dosing schedule of flavopiridol in relapsed chronic lymphocytic leukemia.
Blood 2009;113(12):2637-45.
2009: Xiaojuan Yang; Xiaobin Zhao; Mitch A Phelps; Longzhu Piao; Darlene M Rozewski; Qing Liu; L James Lee; Guido Marcucci; Michael R Grever; John C Byrd; James T Dalton; Robert J Lee
A novel liposomal formulation of flavopiridol.
International journal of pharmaceutics 2009;365(1-2):170-4.
2008: Qing Liu; Katherine L Farley; Amy J Johnson; Natarajan Muthusamy; Craig C Hofmeister; Kristie A Blum; Larry J Schaaf; Michael R Grever; John C Byrd; James T Dalton; Mitch A Phelps
Development and validation of a highly sensitive liquid chromatography/mass spectrometry method for simultaneous quantification of lenalidomide and flavopiridol in human plasma.
Therapeutic drug monitoring 2008;30(5):620-7.
2008: Lisa M Bareford; Mitch A Phelps; Amy B Foraker; Peter Swaan
Intracellular processing of riboflavin in human breast cancer cells.
Molecular pharmaceutics 2008;5(5):839-48.
2008: Jeffrey S Johnston; Mitch A Phelps; Kristie A Blum; William Blum; Michael R Grever; Katherine L Farley; James T Dalton
Development and validation of a rapid and sensitive high-performance liquid chromatography-mass spectroscopy assay for determination of 17-(allylamino)-17-demethoxygeldanamycin and 17-(amino)-17-demethoxygeldanamycin in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2008;871(1):15-21.
2008: Mitch A Phelps; Darlene M Rozewski; Jeffrey S Johnston; Katherine L Farley; Katie A Albanese; John C Byrd; Thomas S Lin; Michael R Grever; James T Dalton
Development and validation of a sensitive liquid chromatography/mass spectrometry method for quantitation of flavopiridol in plasma enables accurate estimation of pharmacokinetic parameters with a clinically active dosing schedule.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2008;868(1-2):110-5.
2007: John C Byrd; Thomas S Lin; James T Dalton; Di Wu; Mitch A Phelps; Beth Fischer; Mollie Moran; Kristie A Blum; Brad H Rovin; Michelle Brooker-McEldowney; Sarah Broering; Larry J Schaaf; Amy J Johnson; David M Lucas; Nyla A Heerema; Gerard Lozanski; Donn C Young; Jose-Ramon Suarez; A Dimitrios Colevas; Michael R Grever
Flavopiridol administered using a pharmacologically derived schedule is associated with marked clinical efficacy in refractory, genetically high-risk chronic lymphocytic leukemia.
Blood 2007;109(2):399-404.
2006: Tesmol G George; Jayaseharan Johnsamuel; Dawn A Delfín; Adam J Yakovich; Mitali Mukherjee; Mitch A Phelps; James T Dalton; Dan L Sackett; Marcel Kaiser; Reto Brun; Karl A Werbovetz
Antikinetoplastid antimitotic activity and metabolic stability of dinitroaniline sulfonamides and benzamides.
Bioorganic & medicinal chemistry 2006;14(16):5699-710.
2006: Clifford W Mason; Vanessa M D'Souza; Lisa M Bareford; Mitch A Phelps; Abhijit Ray; Peter Swaan
Recognition, co-internalization, and recycling of an avian riboflavin carrier protein in human placental trophoblasts.
The Journal of pharmacology and experimental therapeutics 2006;317(2):465-72.
2005: Wenqing Gao; Peter J Reiser; Christopher C Coss; Mitch A Phelps; Jeffrey Kearbey; Duane D Miller; James T Dalton
Selective androgen receptor modulator treatment improves muscle strength and body composition and prevents bone loss in orchidectomized rats.
Endocrinology 2005;146(11):4887-97.
2004: Eric Y Zhang; Mitch A Phelps; Antara Banerjee; Chandra M Khantwal; Cheng Chang; Freek Helsper; Peter Swaan
Topology scanning and putative three-dimensional structure of the extracellular binding domains of the apical sodium-dependent bile acid transporter (SLC10A2).
Biochemistry 2004;43(36):11380-92.
2004: Mitch A Phelps; Amy B Foraker; Wenqing Gao; James T Dalton; Peter Swaan
A novel rhodamine-riboflavin conjugate probe exhibits distinct fluorescence resonance energy transfer that enables riboflavin trafficking and subcellular localization studies.
Molecular pharmaceutics 2004;1(4):257-66.
2004: Zengru Wu; Wenqing Gao; Mitch A Phelps; Di Wu; Duane D Miller; James T Dalton
Favorable effects of weak acids on negative-ion electrospray ionization mass spectrometry.
Analytical chemistry 2004;76(3):839-47.
2003: Se-Ne Huang; Mitch A Phelps; Peter Swaan
Involvement of endocytic organelles in the subcellular trafficking and localization of riboflavin.
The Journal of pharmacology and experimental therapeutics 2003;306(2):681-7.
2003: Mitch A Phelps; Amy B Foraker; Peter Swaan
Cytoskeletal motors and cargo in membrane trafficking: opportunities for high specificity in drug intervention.
Drug discovery today 2003;8(11):494-502.
2002: Eric Y Zhang; Mitch A Phelps; Chang Cheng; Sean Ekins; Peter Swaan
Modeling of active transport systems.
Advanced drug delivery reviews 2002;54(3):329-54.