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Mark Philips
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Research Profile (preview)
Chemicals & Drugs
Anatomy
Physiology
Genes & Molecular Sequences
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Network (preview)
15
Weissmann, Gerald
14
Bivona, Trever
12
Pillinger, Michael
10
Abramson, Steven
9
Michaelson, David
7
Chiu, Vi
6
Silletti, Joseph
5
Wiener, Heidi
5
Mor, Adam
5
Ahearn, Ian
5
Buyon, Jill
4
Choy, E
4
Cox, Adrienne
4
Stock, Jeffry
3
Perez de Castro, Ignacio
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Publications
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All Publications
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2008: Michaelson David; Abidi Wasif; Guardavaccaro Daniele; Zhou Mo; Ahearn Ian; Pagano Michele; Philips Mark R
Rac1 accumulates in the nucleus during the G2 phase of the cell cycle and promotes cell division.
The Journal of cell biology 2008;181(3):485-96.
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2008: Quinlan Margaret P; Quatela Steven E; Philips Mark R; Settleman Jeffrey
Activated Kras, but not Hras or Nras, may initiate tumors of endodermal origin via stem cell expansion.
Molecular and cellular biology 2008;28(8):2659-74.
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2008: Quatela Steven E; Sung Pamela J; Ahearn Ian M; Bivona Trever G; Philips Mark R
Analysis of K-Ras phosphorylation, translocation, and induction of apoptosis.
Methods in enzymology 2008;439():87-102.
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2007: Mor Adam; Philips Mark R; Pillinger Michael H
The role of Ras signaling in lupus T lymphocytes: biology and pathogenesis.
Clinical immunology (Orlando, Fla.) 2007;125(3):215-23.
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2007: Mor Adam; Dustin Michael L; Philips Mark R
Small GTPases and LFA-1 reciprocally modulate adhesion and signaling.
Immunological reviews 2007;218():114-25.
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2007: Mor Adam; Campi Gabriele; Du Guangwei; Zheng Yang; Foster David A; Dustin Michael L; Philips Mark R
The lymphocyte function-associated antigen-1 receptor costimulates plasma membrane Ras via phospholipase D2.
Nature cell biology 2007;9(6):713-9.
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2007: Philips Mark R; Cox Adrienne D
Geranylgeranyltransferase I as a target for anti-cancer drugs.
The Journal of clinical investigation 2007;117(5):1223-5.
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2006: Chang Eric C; Philips Mark R
Spatial segregation of Ras signaling: new evidence from fission yeast.
Cell cycle (Georgetown, Tex.) 2006;5(17):1936-9.
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2006: Onken Brian; Wiener Heidi; Philips Mark R; Chang Eric C
Compartmentalized signaling of Ras in fission yeast.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(24):9045-50.
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2006: Wright Latasha P; Philips Mark R
Thematic review series: lipid posttranslational modifications. CAAX modification and membrane targeting of Ras.
Journal of lipid research 2006;47(5):883-91.
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2006: Bivona Trever G; Quatela Steven E; Bodemann Brian O; Ahearn Ian M; Soskis Michael J; Mor Adam; Miura John; Wiener Heidi H; Wright Latasha; Saba Shahryar G; Yim Duke; Fein Adam; Pérez de Castro Ignacio; Li Chi; Thompson Craig B; Cox Adrienne D; Philips Mark R
PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis.
Molecular cell 2006;21(4):481-93.
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2006: Bivona Trever G; Quatela Steven; Philips Mark R
Analysis of Ras activation in living cells with GFP-RBD.
Methods in enzymology 2006;407():128-43.
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2006: Mor Adam; Philips Mark R
Compartmentalized Ras/MAPK signaling.
Annual review of immunology 2006;24():771-800.
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2006: Michaelson David; Philips Mark
The use of GFP to localize Rho GTPases in living cells.
Methods in enzymology 2006;406():296-315.
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2005: Philips Mark R
Teaching resources. Imaging signal transduction in living cells with fluorescent proteins.
Science's STKE : signal transduction knowledge environment 2005;2005(314):tr28.
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2005: Chan Amanda Y; Coniglio Salvatore J; Chuang Ya-yu; Michaelson David; Knaus Ulla G; Philips Mark R; Symons Marc
Roles of the Rac1 and Rac3 GTPases in human tumor cell invasion.
Oncogene 2005;24(53):7821-9.
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2005: Bivona Trever G; Philips Mark R
Analysis of Ras and Rap activation in living cells using fluorescent Ras binding domains.
Methods (San Diego, Calif.) 2005;37(2):138-45.
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2005: Michaelson David; Ali Wasif; Chiu Vi K; Bergo Martin; Silletti Joseph; Wright Latasha; Young Stephen G; Philips Mark
Postprenylation CAAX processing is required for proper localization of Ras but not Rho GTPases.
Molecular biology of the cell 2005;16(4):1606-16.
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2005: Jordan J Dedrick; He John Cijiang; Eungdamrong Narat J; Gomes Ivone; Ali Wasif; Nguyen Tracy; Bivona Trever G; Philips Mark R; Devi Lakshmi A; Iyengar Ravi
Cannabinoid receptor-induced neurite outgrowth is mediated by Rap1 activation through G(alpha)o/i-triggered proteasomal degradation of Rap1GAPII.
The Journal of biological chemistry 2005;280(12):11413-21.
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2004: Perez de Castro Ignacio; Bivona Trever G; Philips Mark R; Pellicer Angel
Ras activation in Jurkat T cells following low-grade stimulation of the T-cell receptor is specific to N-Ras and occurs only on the Golgi apparatus.
Molecular and cellular biology 2004;24(8):3485-96.
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2004: Walker Simon A; Kupzig Sabine; Bouyoucef Dalila; Davies Louise C; Tsuboi Takashi; Bivona Trever G; Cozier Gyles E; Lockyer Peter J; Buckler Alan; Rutter Guy A; Allen Maxine J; Philips Mark R; Cullen Peter J
Identification of a Ras GTPase-activating protein regulated by receptor-mediated Ca2+ oscillations.
The EMBO journal 2004;23(8):1749-60.
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2004: Dustin Michael L; Bivona Trever G; Philips Mark R
Membranes as messengers in T cell adhesion signaling.
Nature immunology 2004;5(4):363-72.
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2004: Philips Mark R
Methotrexate and Ras methylation: a new trick for an old drug?
Science's STKE : signal transduction knowledge environment 2004;2004(225):pe13.
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2004: Zhang Si Qing; Yang Wentian; Kontaridis Maria I; Bivona Trever G; Wen Gengyun; Araki Toshiyuki; Luo Jincai; Thompson Julie A; Schraven Burkhart L; Philips Mark R; Neel Benjamin G
Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment.
Molecular cell 2004;13(3):341-55.
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2004: Bivona Trever G; Wiener Heidi H; Ahearn Ian M; Silletti Joseph; Chiu Vi K; Philips Mark R
Rap1 up-regulation and activation on plasma membrane regulates T cell adhesion.
The Journal of cell biology 2004;164(3):461-70.
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2004: Chiu Vi K; Silletti Joseph; Dinsell Victoria; Wiener Heidi; Loukeris Kristina; Ou Guoming; Philips Mark R; Pillinger Michael H
Carboxyl methylation of Ras regulates membrane targeting and effector engagement.
The Journal of biological chemistry 2004;279(8):7346-52.
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2003: Mohney Robert P; Das Margaret; Bivona Trever G; Hanes Richard; Adams Anthony G; Philips Mark R; O'Bryan John P
Intersectin activates Ras but stimulates transcription through an independent pathway involving JNK.
The Journal of biological chemistry 2003;278(47):47038-45.
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2003: Bivona Trever G; Pérez De Castro Ignacio; Ahearn Ian M; Grana Theresa M; Chiu Vi K; Lockyer Peter J; Cullen Peter J; Pellicer Angel; Cox Adrienne D; Philips Mark R
Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1.
Nature 2003;424(6949):694-8.
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2003: Bivona Trever G; Philips Mark R
Ras pathway signaling on endomembranes.
Current opinion in cell biology 2003;15(2):136-42.
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2002: Michaelson David; Ahearn Ian; Bergo Martin; Young Stephen; Philips Mark
Membrane trafficking of heterotrimeric G proteins via the endoplasmic reticulum and Golgi.
Molecular biology of the cell 2002;13(9):3294-302.
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2002: Chiu Vi K; Bivona Trever; Hach Angela; Sajous J Bernard; Silletti Joseph; Wiener Heidi; Johnson Ronald L; Cox Adrienne D; Philips Mark R
Ras signalling on the endoplasmic reticulum and the Golgi.
Nature cell biology 2002;4(5):343-50.
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2002: Michaelson David; Philips Mark R
Activity of G gamma prenylcysteine carboxyl methyltransferase.
Methods in enzymology 2002;344():234-45.
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2001: Murphy G A; Jillian S A; Michaelson D; Philips M R; D'Eustachio P; Rush M G
Signaling mediated by the closely related mammalian Rho family GTPases TC10 and Cdc42 suggests distinct functional pathways.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 2001;12(3):157-67.
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2001: Michaelson D; Silletti J; Murphy G; D'Eustachio P; Rush M; Philips M R
Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding.
The Journal of cell biology 2001;152(1):111-26.
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2001: Choy E; Philips M
Green fluorescent protein-tagged Ras proteins for intracellular localization.
Methods in enzymology 2001;332():50-64.
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2000: Choy E; Philips M
Expression and activity of human prenylcysteine-directed carboxyl methyltransferase.
Methods in enzymology 2000;325():101-14.
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1999: Choy E; Chiu V K; Silletti J; Feoktistov M; Morimoto T; Michaelson D; Ivanov I E; Philips M R
Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi.
Cell 1999;98(1):69-80.
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1998: Pillinger M H; Capodici C; Rosenthal P; Kheterpal N; Hanft S; Philips M R; Weissmann G
Modes of action of aspirin-like drugs: salicylates inhibit erk activation and integrin-dependent neutrophil adhesion.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(24):14540-5.
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1998: Capodici C; Pillinger M H; Han G; Philips M R; Weissmann G
Integrin-dependent homotypic adhesion of neutrophils. Arachidonic acid activates Raf-1/Mek/Erk via a 5-lipoxygenase- dependent pathway.
The Journal of clinical investigation 1998;102(1):165-75.
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1998: Dai Q; Choy E; Chiu V; Romano J; Slivka S R; Steitz S A; Michaelis S; Philips M R
Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum.
The Journal of biological chemistry 1998;273(24):15030-4.
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1997: Buyon J P; Philips M R; Merrill J T; Slade S G; Leszczynska-Piziak J; Abramson S B
Differential phosphorylation of the beta2 integrin CD11b/CD18 in the plasma and specific granule membranes of neutrophils.
Journal of leukocyte biology 1997;61(3):313-21.
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1996: Pillinger M H; Feoktistov A S; Capodici C; Solitar B; Levy J; Oei T T; Philips M R
Mitogen-activated protein kinase in neutrophils and enucleate neutrophil cytoplasts: evidence for regulation of cell-cell adhesion.
The Journal of biological chemistry 1996;271(20):12049-56.
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1995: Philips M R; Feoktistov A; Pillinger M H; Abramson S B
Translocation of p21rac2 from cytosol to plasma membrane is neither necessary nor sufficient for neutrophil NADPH oxidase activity.
The Journal of biological chemistry 1995;270(19):11514-21.
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1995: Philips M R; Staud R; Pillinger M; Feoktistov A; Volker C; Stock J B; Weissmann G
Activation-dependent carboxyl methylation of neutrophil G-protein gamma subunit.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(6):2283-7.
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1995: Pillinger M H; Philips M R; Feoktistov A; Weissmann G
Crosstalk in signal transduction via EP receptors: prostaglandin E1 inhibits chemoattractant-induced mitogen-activated protein kinase activity in human neutrophils.
Advances in prostaglandin, thromboxane, and leukotriene research 1995;23():311-6.
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1995: Volker C; Pillinger M H; Philips M R; Stock J B
Prenylcysteine analogs to study function of carboxylmethylation in signal transduction.
Methods in enzymology 1995;250():216-25.
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1995: Philips M R; Pillinger M H
Prenylcysteine-directed carboxyl methyltransferase activity in human neutrophil membranes.
Methods in enzymology 1995;256():49-63.
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1994: Abramson S B; Leszczynska-Piziak J; Clancy R M; Philips M; Weissmann G
Inhibition of neutrophil function by aspirin-like drugs (NSAIDS): requirement for assembly of heterotrimeric G proteins in bilayer phospholipid.
Biochemical pharmacology 1994;47(3):563-72.
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1994: Pillinger M H; Volker C; Stock J B; Weissmann G; Philips M R
Characterization of a plasma membrane-associated prenylcysteine-directed alpha carboxyl methyltransferase in human neutrophils.
The Journal of biological chemistry 1994;269(2):1486-92.
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1993: Philips M R; Pillinger M H; Staud R; Volker C; Rosenfeld M G; Weissmann G; Stock J B
Carboxyl methylation of Ras-related proteins during signal transduction in neutrophils.
Science (New York, N.Y.) 1993;259(5097):977-80.
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1992: Cronstein B N; Levin R I; Philips M; Hirschhorn R; Abramson S B; Weissmann G
Neutrophil adherence to endothelium is enhanced via adenosine A1 receptors and inhibited via adenosine A2 receptors.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(7):2201-6.
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1991: Philips M R; Abramson S B; Kolasinski S L; Haines K A; Weissmann G; Rosenfeld M G
Low molecular weight GTP-binding proteins in human neutrophil granule membranes.
The Journal of biological chemistry 1991;266(2):1289-98.
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1990: Haines K A; Reibman J; Callegari P E; Abramson S B; Philips M R; Weissmann G
Cocaine and its derivatives blunt neutrophil functions without influencing phosphorylation of a 47-kilodalton component of the reduced nicotinamide-adenine dinucleotide phosphate oxidase.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(12):4757-64.
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1990: Abramson S B; Cherksey B; Gude D; Leszczynska-Piziak J; Philips M R; Blau L; Weissmann G
Nonsteroidal antiinflammatory drugs exert differential effects on neutrophil function and plasma membrane viscosity. Studies in human neutrophils and liposomes.
Inflammation 1990;14(1):11-30.
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1990: Buyon J P; Slade S G; Reibman J; Abramson S B; Philips M R; Weissmann G; Winchester R
Constitutive and induced phosphorylation of the alpha- and beta-chains of the CD11/CD18 leukocyte integrin family. Relationship to adhesion-dependent functions.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(1):191-7.
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1988: Philips M R; Buyon J P; Winchester R; Weissmann G; Abramson S B
Up-regulation of the iC3b receptor (CR3) is neither necessary nor sufficient to promote neutrophil aggregation.
The Journal of clinical investigation 1988;82(2):495-501.
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1988: Buyon J P; Abramson S B; Philips M R; Slade S G; Ross G D; Weissmann G; Winchester R J
Dissociation between increased surface expression of gp165/95 and homotypic neutrophil aggregation.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(9):3156-60.
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1988: Hopkins P; Belmont H M; Buyon J; Philips M; Weissmann G; Abramson S B
Increased levels of plasma anaphylatoxins in systemic lupus erythematosus predict flares of the disease and may elicit vascular injury in lupus cerebritis.
Arthritis and rheumatism 1988;31(5):632-41.
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