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Sjaak Philipsen

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Rejane Hughes Carvalho; Frank Grosveld; Vanja Haberle; Jun Hou; Boris Lenhard; Joachim Aerts; Sjaak Philipsen
Genomewide DNA methylation analysis identifies novel methylated genes in non-small-cell lung carcinomas.
Farzin Pourfarzad; Wilfred van Ijcken; Marieke von Lindern; Azita Azarkeivan; Fatemehsadat Esteghamat; Jun Hou; Sima Kheradmand Kia; Hossein Najmabadi; Sjaak Philipsen; Frank Grosveld
Hydroxyurea responsiveness in β-thalassemic patients is determined by the stress response adaptation of erythroid progenitors and their differentiation propensity.
Christina Tafrali; Branka Zukic; Sonja Pavlovic; Sjaak Philipsen; Konstantinos Poulas; Milena Radmilovic; Eleana F Stavrou; Maja Stojiljkovic-Petrovic; Marina Bartsakoulia; Joseph Borg; Alexander E Felice; Marianthi Georgitsi; Olga Giannakopoulou; Emily Giannopoulou; Alexandra Kourakli; Polyxeni Lambropoulou; Arsinoi Paizi; Adamantia Papachatzopoulou; George P Patrinos
Genomic variation in the MAP3K5 gene is associated with β-thalassemia disease severity and hydroxyurea treatment efficacy.

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All Publications

2013: Rejane Hughes Carvalho; Frank Grosveld; Vanja Haberle; Jun Hou; Boris Lenhard; Joachim Aerts; Sjaak Philipsen
Genomewide DNA methylation analysis identifies novel methylated genes in non-small-cell lung carcinomas.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2013;8(5):562-73.
2013: Farzin Pourfarzad; Wilfred van Ijcken; Marieke von Lindern; Azita Azarkeivan; Fatemehsadat Esteghamat; Jun Hou; Sima Kheradmand Kia; Hossein Najmabadi; Sjaak Philipsen; Frank Grosveld
Hydroxyurea responsiveness in β-thalassemic patients is determined by the stress response adaptation of erythroid progenitors and their differentiation propensity.
Haematologica 2013;98(5):696-704.
2013: Christina Tafrali; Branka Zukic; Sonja Pavlovic; Sjaak Philipsen; Konstantinos Poulas; Milena Radmilovic; Eleana F Stavrou; Maja Stojiljkovic-Petrovic; Marina Bartsakoulia; Joseph Borg; Alexander E Felice; Marianthi Georgitsi; Olga Giannakopoulou; Emily Giannopoulou; Alexandra Kourakli; Polyxeni Lambropoulou; Arsinoi Paizi; Adamantia Papachatzopoulou; George P Patrinos
Genomic variation in the MAP3K5 gene is associated with β-thalassemia disease severity and hydroxyurea treatment efficacy.
Pharmacogenomics 2013;14(5):469-83.
2013: Elaine Dzierzak; Sjaak Philipsen
Erythropoiesis: development and differentiation.
Cold Spring Harbor perspectives in medicine 2013;3(4):a011601.
2013: Fatemehsadat Esteghamat; Nynke Gillemans; Frank Grosveld; Ursula Klingmüller; Ivan Bilic; Thamar Bryn van Dijk; Meinrad Busslinger; Ileana Cantù; Emile van den Akker; Teus van Gent; Kirsten van Lom; Marieke von Lindern; Sjaak Philipsen
Erythropoiesis and globin switching in compound Klf1::Bcl11a mutant mice.
Blood 2013;121(13):2553-62.
2012: Shin'ya Ohmori; Yasushi Ishijima; Takashi Moriguchi; Sjaak Philipsen; Mikiko Suzuki; Jun Takai; Masayuki Yamamoto; Kinuko Ohneda
Regulation of GATA factor expression is distinct between erythroid and mast cell lineages.
Molecular and cellular biology 2012;32(23):4742-55.
2012: Pavlos Fanis; Nynke Gillemans; Frank Grosveld; Sjaak Philipsen; Farzin Pourfarzad; Ratna K Vadlamudi; Ali Aghajanirefah; Jeroen A A Demmers; Fatemehsadat Esteghamat; Thamar B van Dijk
Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation.
Molecular & cellular proteomics : MCP 2012;11(11):1263-73.
2012: Ksenija Drabek; Umut Akinci; Jean-Charles Boisset; Thomas Clapes; Dubravka Drabek; Frank Grosveld; Laura Gutiérrez; Rudi W Hendriks; Joseph E Italiano; Zhe Liu; Helder Maiato; Marjolein Meinders; Clara Melo; Mieke Mommaas; Tatjana Nikolic; Sunita R Patel; Ana L Pereira; Sjaak Philipsen; Catherine Robin; Clara Sambade; Mirjam van den Hout; Jeffrey van Haren; Wilfred van Ijcken; Marcel Vermeij; Niels Galjart
The microtubule plus-end tracking protein CLASP2 is required for hematopoiesis and hematopoietic stem cell maintenance.
Cell reports 2012;2(4):781-8.
2012: Joseph Borg; Soteroula Christou; Alexander E Felice; Marianthi Georgitsi; Frank G Grosveld; Jun Hou; Sophia Karkabouna; Marina Kleanthous; Alexandra Kourakli; Christina Lappa-Manakou; Carsten Lederer; Zeliha Ozgur; Adamantia Papachatzopoulou; Sjaak Philipsen; Marios Phylactides; Eleana F Stavrou; Christina Tafrali; Wilfred van Ijcken; Marieke von Lindern; Marina Bartsakoulia; George P Patrinos
KLF10 gene expression is associated with high fetal hemoglobin levels and with response to hydroxyurea treatment in β-hemoglobinopathy patients.
Pharmacogenomics 2012;13(13):1487-500.
2012: Mehdi Banan; Zahra Deilami; Elika Esmaeilzadeh-Gharehdaghi; Fatemehsadat Esteghamat; Samaneh Farashi; Majid Nezami; Sjaak Philipsen; Farzin Pourfarzad; A M Ali Imam; Hossein Najmabadi
cAMP response element-binding protein 1 is required for hydroxyurea-mediated induction of γ-globin expression in K562 cells.
Clinical and experimental pharmacology & physiology 2012;39(6):510-7.
2012: Petros Papadopoulos; George P Patrinos; Sjaak Philipsen; Reinier van der Linden; Dubravka Drabek; Laura Gutiérrez; John Kong-A-San; Alex Maas; Frank Grosveld
A dual reporter mouse model of the human β-globin locus: applications and limitations.
PloS one 2012;7(12):e51272.
2012: Rejane Hughes Carvalho; John Foekens; Frank Grosveld; Vanja Haberle; Jun Hou; Christel Kockx; Boris Lenhard; Erikjan Rijkers; Anieta Sieuwerts; Supat Thongjuea; Teus van Gent; Wilfred van Ijcken; Mirjam van Vroonhoven; Joachim Aerts; Rutger Brouwer; Sjaak Philipsen
Genome-wide DNA methylation profiling of non-small cell lung carcinomas.
Epigenetics & chromatin 2012;5(1):9.
2011: Sten F Libregts; Alexander M de Bruin; Laura Gutiérrez; Zeliha Ozgür; Petros Papadopoulos; Sjaak Philipsen; Wilfred van Ijcken; Felix M Wensveen; Martijn A Nolte
Chronic IFN-γ production in mice induces anemia by reducing erythrocyte life span and inhibiting erythropoiesis through an IRF-1/PU.1 axis.
Blood 2011;118(9):2578-88.
2011: Fatemehsadat Esteghamat; Pavlos Fanis; Rastislav Horos; Jun Hou; Zeliha Ozgür; Farzin Pourfarzad; Reinier van der Linden; Thamar B van Dijk; Wilfred van IJcken; Marieke von Lindern; Harald Braun; Sylvia Dekker; Jeroen A A Demmers; Sjaak Philipsen
The DNA binding factor Hmg20b is a repressor of erythroid differentiation.
Haematologica 2011;96(9):1252-60.
2011: Erik Engelen; Umut Akinci; Jan Christian Bryne; Jun Hou; Cristina Gontan; Maaike Moen; Dorota Szumska; Christel Kockx; Wilfred van Ijcken; Dick H W Dekkers; Jeroen A A Demmers; Erik-Jan Rijkers; Shoumo Bhattacharya; Sjaak Philipsen; Larysa H Pevny; Frank G Grosveld; Robbert Rottier; Boris Lenhard; Raymond A Poot
Sox2 cooperates with Chd7 to regulate genes that are mutated in human syndromes.
Nature genetics 2011;43(6):607-11.
2011: Wei Zhang; Zhipeng Tian; Sha Sha; Lydia Yuk Luen Cheng; Sjaak Philipsen; Kian-Cheng Tan-Un
Functional and sequence analysis of human neuroglobin gene promoter region.
Biochimica et biophysica acta 2011;1809(4-6):236-44.
2010: Bastian Stielow; Imme Krüger; Rolf Diezko; Florian Finkernagel; Nynke Gillemans; John Kong-A-San; Sjaak Philipsen; Guntram Suske
Epigenetic silencing of spermatocyte-specific and neuronal genes by SUMO modification of the transcription factor Sp3.
PLoS genetics 2010;6(11):e1001203.
2010: Joseph Borg; Petros Papadopoulos; Marianthi Georgitsi; Laura Gutiérrez; Godfrey Grech; Pavlos Fanis; Marios Phylactides; Annemieke J M H Verkerk; Peter van der Spek; Christian Scerri; Wilhelmina Cassar; Ruth Galdies; Wilfred van Ijcken; Zeliha Ozgür; Nynke Gillemans; Jun Hou; Marisa Bugeja; Frank G Grosveld; Marieke von Lindern; Alex E Felice; George P Patrinos; Sjaak Philipsen
Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin.
Nature genetics 2010;42(9):801-5.
2010: Gergely T Kozma; Fabrizio Martelli; Maria Verrucci; Laura Gutiérrez; Giovanni Migliaccio; Massimo Sanchez; Elena Alfani; Sjaak Philipsen; Anna Rita Migliaccio
Dynamic regulation of Gata1 expression during the maturation of conventional dendritic cells.
Experimental hematology 2010;38(6):489-503.e1.
2010: Jun Hou; Joachim Aerts; Bianca den Hamer; Wilfred van Ijcken; Michael A Den Bakker; Peter Riegman; Cor van der Leest; Peter van der Spek; John A Foekens; Henk C Hoogsteden; Frank Grosveld; Sjaak Philipsen
Gene expression-based classification of non-small cell lung carcinomas and survival prediction.
PloS one 2010;5(4):e10312.
2010: Frank Baur; Kerstin Nau; Dennis Sadic; Lena Allweiss; Hans-Peter Elsässer; Nynke Gillemans; Ton de Wit; Imme Krüger; Marion Vollmer; Sjaak Philipsen; Guntram Suske
Specificity protein 2 (Sp2) is essential for mouse development and autonomous proliferation of mouse embryonic fibroblasts.
PloS one 2010;5(3):e9587.
2010: Thamar B van Dijk; Nynke Gillemans; Claudia Stein; Pavlos Fanis; Jeroen A A Demmers; Mariëtte van de Corput; Jeroen Essers; Frank Grosveld; Uta-Maria Bauer; Sjaak Philipsen
Friend of Prmt1, a novel chromatin target of protein arginine methyltransferases.
Molecular and cellular biology 2010;30(1):260-72.
2008: Kwun-Nok Mimi Man; Sjaak Philipsen; Kian-Cheng Tan-Un
Localization and expression pattern of cytoglobin in carbon tetrachloride-induced liver fibrosis.
Toxicology letters 2008;183(1-3):36-44.
2008: Clive McKimmie; Alasdair R Fraser; Chris Hansell; Laura Gutiérrez; Sjaak Philipsen; Laura Connell; Antal Rot; Mariola Kurowska-Stolarska; Paz Carreno; Monika Pruenster; Ching-Chung Chu; Giovanna Lombardi; Christina Halsey; Iain B McInnes; Foo Y Liew; Robert J B Nibbs; Gerard J Graham
Hemopoietic cell expression of the chemokine decoy receptor D6 is dynamic and regulated by GATA1.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(11):8171-81.
2008: Clive McKimmie; Alasdair R Fraser; Chris Hansell; Laura Gutiérrez; Sjaak Philipsen; Laura Connell; Antal Rot; Mariola Kurowska-Stolarska; Paz Carreno; Monika Pruenster; Chung-Ching Chu; Giovanna Lombardi; Christina Halsey; Iain B McInnes; Foo Y Liew; Robert J B Nibbs; Gerard J Graham
Hemopoietic cell expression of the chemokine decoy receptor D6 is dynamic and regulated by GATA1.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(5):3353-63.
2008: Jing Xu; Jun-Ying Zhou; Wei-Zen Wei; Sjaak Philipsen; Gen Sheng Wu
Sp1-mediated TRAIL induction in chemosensitization.
Cancer research 2008;68(16):6718-26.
2008: Laura Gutiérrez; Saho Tsukamoto; Mikiko Suzuki; Harumi Yamamoto-Mukai; Masayuki Yamamoto; Sjaak Philipsen; Kinuko Ohneda
Ablation of Gata1 in adult mice results in aplastic crisis, revealing its essential role in steady-state and stress erythropoiesis.
Blood 2008;111(8):4375-85.
2008: Jackson Chan; Albert Wai; Sjaak Philipsen; Kian-Cheng Tan-Un
5'HS5 of the human beta-globin locus control region is dispensable for the formation of the beta-globin active chromatin hub.
PloS one 2008;3(5):e2134.
2007: Xiumei Guo; Sjaak Philipsen; Kian-Cheng Tan-Un
Study of the hypoxia-dependent regulation of human CYGB gene.
Biochemical and biophysical research communications 2007;364(1):145-50.
2007: Pieter Fokko Van Loo; Edris A F Mahtab; Lambertus J Wisse; Jun Hou; Frank Grosveld; Guntram Suske; Sjaak Philipsen; Adriana C Gittenberger-De Groot
Transcription factor Sp3 knockout mice display serious cardiac malformations.
Molecular and cellular biology 2007;27(24):8571-82.
2007: Laura Gutiérrez; Tatjana Nikolic; Thamar B van Dijk; Hamida Hammad; Nanda Vos; Monique Willart; Frank Grosveld; Sjaak Philipsen; Bart N Lambrecht
Gata1 regulates dendritic-cell development and survival.
Blood 2007;110(6):1933-41.
2007: Imme Krüger; Marion Vollmer; David G Simmons; David Simmons; Hans-Peter Elsässer; Sjaak Philipsen; Guntram Suske
Sp1/Sp3 compound heterozygous mice are not viable: impaired erythropoiesis and severe placental defects.
Developmental dynamics : an official publication of the American Association of Anatomists 2007;236(8):2235-44.
2007: Rita Ferreira; Albert W K Wai; Ritsuko Shimizu; Nynke Gillemans; Robbert Rottier; Marieke von Lindern; Kinuko Ohneda; Frank Grosveld; Masayuki Yamamoto; Sjaak Philipsen
Dynamic regulation of Gata factor levels is more important than their identity.
Blood 2007;109(12):5481-90.
2006: Anna Rita Migliaccio; Sjaak Philipsen
The return of Romeo. Scientists' international mobility and the future of research in Europe.
EMBO reports 2006;7(11):1067-71.
2006: Anna Rita Migliaccio; Sjaak Philipsen
Reflections on the European Union Eurythron Network Meeting "Molecular Control of Erythropoiesis," September 22-23, 2005, Istituto Superiore di Sanità, Rome, Italy.
Stem cells (Dayton, Ohio) 2006;24(11):2478-82.
2006: Mikiko Suzuki; Kinuko Ohneda; Sakie Hosoya-Ohmura; Saho Tsukamoto; Osamu Ohneda; Sjaak Philipsen; Masayuki Yamamoto
Real-time monitoring of stress erythropoiesis in vivo using Gata1 and beta-globin LCR luciferase transgenic mice.
Blood 2006;108(2):726-33.
2006: Xiumei Guo; Sjaak Philipsen; Kian-Cheng Tan-Un
Characterization of human cytoglobin gene promoter region.
Biochimica et biophysica acta 2006;1759(5):208-15.
2006: Patrick Rodriguez; Harald Braun; Katarzyna E Kolodziej; Ernie de Boer; Jennifer Campbell; Edgar Bonte; Frank Grosveld; Sjaak Philipsen; John Strouboulis
Isolation of transcription factor complexes by in vivo biotinylation tagging and direct binding to streptavidin beads.
Methods in molecular biology (Clifton, N.J.) 2006;338():305-23.
2005: Laura Gutiérrez; Fokke Lindeboom; Rita Ferreira; Roy Drissen; Frank Grosveld; David Whyatt; Sjaak Philipsen
A hanging drop culture method to study terminal erythroid differentiation.
Experimental hematology 2005;33(10):1083-91.
2005: Siska Driegen; Rita Ferreira; Arend van Zon; John Strouboulis; Martine Jaegle; Frank Grosveld; Sjaak Philipsen; Dies Meijer
A generic tool for biotinylation of tagged proteins in transgenic mice.
Transgenic research 2005;14(4):477-82.
2005: Xiaoqing Pan; Osamu Ohneda; Kinuko Ohneda; Fokke Lindeboom; Fumiko Iwata; Ritsuko Shimizu; Masumi Nagano; Naruyoshi Suwabe; Sjaak Philipsen; Kim-Chew Lim; James Douglas Engel; Masayuki Yamamoto
Graded levels of GATA-1 expression modulate survival, proliferation, and differentiation of erythroid progenitors.
The Journal of biological chemistry 2005;280(23):22385-94.
2005: Roy Drissen; Marieke von Lindern; Andrea Kolbus; Siska Driegen; Peter Steinlein; Hartmut Beug; Frank Grosveld; Sjaak Philipsen
The erythroid phenotype of EKLF-null mice: defects in hemoglobin metabolism and membrane stability.
Molecular and cellular biology 2005;25(12):5205-14.
2005: Guntram Suske; Elspeth Bruford; Sjaak Philipsen
Mammalian SP/KLF transcription factors: bring in the family.
Genomics 2005;85(5):551-6.
2005: Rita Ferreira; Kinuko Ohneda; Masayuki Yamamoto; Sjaak Philipsen
GATA1 function, a paradigm for transcription factors in hematopoiesis.
Molecular and cellular biology 2005;25(4):1215-27.
2004: Ritsuko Shimizu; Takashi Kuroha; Osamu Ohneda; Xiaoqing Pan; Kinuko Ohneda; Satoru Takahashi; Sjaak Philipsen; Masayuki Yamamoto
Leukemogenesis caused by incapacitated GATA-1 function.
Molecular and cellular biology 2004;24(24):10814-25.
2004: Roy Drissen; Robert-Jan Palstra; Nynke Gillemans; Erik Splinter; Frank Grosveld; Sjaak Philipsen; Wouter de Laat
The active spatial organization of the beta-globin locus requires the transcription factor EKLF.
Genes & development 2004;18(20):2485-90.
2004: Laura Gutiérrez; Fokke Lindeboom; An Langeveld; Frank Grosveld; Sjaak Philipsen; David Whyatt
Homotypic signalling regulates Gata1 activity in the erythroblastic island.
Development (Cambridge, England) 2004;131(13):3183-93.
2004: Michelle A Christensen; Weihui Zhou; Hong Qing; Anna Lehman; Sjaak Philipsen; Weihong Song
Transcriptional regulation of BACE1, the beta-amyloid precursor protein beta-secretase, by Sp1.
Molecular and cellular biology 2004;24(2):865-74.
2003: Fokke Lindeboom; Nynke Gillemans; Alar Karis; Martine Jaegle; Dies Meijer; Frank Grosveld; Sjaak Philipsen
A tissue-specific knockout reveals that Gata1 is not essential for Sertoli cell function in the mouse.
Nucleic acids research 2003;31(18):5405-12.
2003: Albert W K Wai; Nynke Gillemans; Selina Raguz-Bolognesi; Sara Pruzina; Gaetano Zafarana; Dies Meijer; Sjaak Philipsen; Frank Grosveld
HS5 of the human beta-globin locus control region: a developmental stage-specific border in erythroid cells.
The EMBO journal 2003;22(17):4489-500.
2003: Pieter Fokko Van Loo; Peter Bouwman; Kam-Wing Ling; Sabine Middendorp; Guntram Suske; Frank Grosveld; Elaine Dzierzak; Sjaak Philipsen; Rudolf W Hendriks
Impaired hematopoiesis in mice lacking the transcription factor Sp3.
Blood 2003;102(3):858-66.
2003: Nynke Gillemans; Tara McMorrow; Rita Tewari; Albert W K Wai; Carola Burgtorf; Dubravka Drabek; Nicki Ventress; An Langeveld; Douglas Higgs; Kian-Cheng Tan-Un; Frank Grosveld; Sjaak Philipsen
Functional and comparative analysis of globin loci in pufferfish and humans.
Blood 2003;101(7):2842-9.
2002: Peter Bouwman; Sjaak Philipsen
Regulation of the activity of Sp1-related transcription factors.
Molecular and cellular endocrinology 2002;195(1-2):27-38.
2001: H Göllner; Peter Bouwman; M Mangold; Alar Karis; Harald Braun; I Rohner; Adriana del Rey; Hugo O Besedovsky; A Meinhardt; M van den Broek; T Cutforth; Frank Grosveld; Sjaak Philipsen; Guntram Suske
Complex phenotype of mice homozygous for a null mutation in the Sp4 transcription factor gene.
Genes to cells : devoted to molecular & cellular mechanisms 2001;6(8):689-97.
2001: H Göllner; C Dani; B Phillips; Sjaak Philipsen; Guntram Suske
Impaired ossification in mice lacking the transcription factor Sp3.
Mechanisms of development 2001;106(1-2):77-83.
2001: Jonathan Flint; Cristina Tufarelli; JF Peden; Kevin Clark; Rachael J Daniels; Ross Hardison; Webb Miller; Sjaak Philipsen; Kian-Cheng Tan-Un; Tara McMorrow; Jon Frampton; BLANCHE ALTER; Anna-Maria Frischauf; Douglas R Higgs
Comparative genome analysis delimits a chromosomal domain and identifies key regulatory elements in the alpha globin cluster.
Human molecular genetics 2001;10(4):371-82.
2000: Gaetano Zafarana; Robbert Rottier; Frank Grosveld; Sjaak Philipsen
Erythroid overexpression of C/EBPgamma in transgenic mice affects gamma-globin expression and fetal liver erythropoiesis.
The EMBO journal 2000;19(21):5856-63.
2000: Tara McMorrow; A van den Wijngaard; A Wollenschlaeger; Mariette van de Corput; K Monkhorst; T Trimborn; P Fraser; Maarten van Lohuizen; T Jenuwein; Malek Djabali; Sjaak Philipsen; Frank Grosveld; E Milot
Activation of the beta globin locus by transcription factors and chromatin modifiers.
The EMBO journal 2000;19(18):4986-96.
2000: David Whyatt; Fokke Lindeboom; Alar Karis; Rita Ferreira; E Milot; Rudolf W Hendriks; M de Bruijn; An Langeveld; J Gribnau; Frank Grosveld; Sjaak Philipsen
An intrinsic but cell-nonautonomous defect in GATA-1-overexpressing mouse erythroid cells.
Nature 2000;406(6795):519-24.
2000: Peter Bouwman; H Göllner; Hans-Peter Elsässer; G Eckhoff; Alar Karis; Frank Grosveld; Sjaak Philipsen; Guntram Suske
Transcription factor Sp3 is essential for post-natal survival and late tooth development.
The EMBO journal 2000;19(4):655-61.
1999: Sjaak Philipsen; Guntram Suske
A tale of three fingers: the family of mammalian Sp/XKLF transcription factors.
Nucleic acids research 1999;27(15):2991-3000.
1999: S Müller; Alex Maas; T C Islam; P Sideras; Guntram Suske; Sjaak Philipsen; K G Xanthopoulos; Rudolf W Hendriks; C I Smith
Synergistic activation of the human Btk promoter by transcription factors Sp1/3 and PU.1.
Biochemical and biophysical research communications 1999;259(2):364-9.
1998: Nynke Gillemans; Rita Tewari; Fokke Lindeboom; Robbert Rottier; Ton de Wit; M Wijgerde; Frank Grosveld; Sjaak Philipsen
Altered DNA-binding specificity mutants of EKLF and Sp1 show that EKLF is an activator of the beta-globin locus control region in vivo.
Genes & development 1998;12(18):2863-73.
1998: Rita Tewari; Nynke Gillemans; M Wijgerde; B Nuez; Marieke von Lindern; Frank Grosveld; Sjaak Philipsen
Erythroid Krüppel-like factor (EKLF) is active in primitive and definitive erythroid cells and is required for the function of 5'HS3 of the beta-globin locus control region.
The EMBO journal 1998;17(8):2334-41.
1997: M Marin; Alar Karis; P Visser; Frank Grosveld; Sjaak Philipsen
Transcription factor Sp1 is essential for early embryonic development but dispensable for cell growth and differentiation.
Cell 1997;89(4):619-28.
1997: David Whyatt; Alar Karis; I C Harkes; A Verkerk; Nynke Gillemans; Andrew G Elefanty; G Vairo; Rob E Ploemacher; Frank Grosveld; Sjaak Philipsen
The level of the tissue-specific factor GATA-1 affects the cell-cycle machinery.
Genes and function 1997;1(1):11-24.
1996: R Tewari; Nynke Gillemans; A Harper; M Wijgerde; G Zafarana; Dubravka Drabek; Frank Grosveld; Sjaak Philipsen
The human beta-globin locus control region confers an early embryonic erythroid-specific expression pattern to a basic promoter driving the bacterial lacZ gene.
Development (Cambridge, England) 1996;122(12):3991-9.
1996: M Wijgerde; J Gribnau; T Trimborn; B Nuez; Sjaak Philipsen; Frank Grosveld; P Fraser
The role of EKLF in human beta-globin gene competition.
Genes & development 1996;10(22):2894-902.
1996: James Ellis; K C Tan-Un; A Harper; D Michalovich; N Yannoutsos; Sjaak Philipsen; Frank Grosveld
A dominant chromatin-opening activity in 5' hypersensitive site 3 of the human beta-globin locus control region.
The EMBO journal 1996;15(3):562-8.
1994: S Pruzina; Michael Antoniou; J Hurst; Frank Grosveld; Sjaak Philipsen
Transcriptional activation by hypersensitive site three of the human beta-globin locus control region in murine erythroleukemia cells.
Biochimica et biophysica acta 1994;1219(2):351-60.
1993: J Wijnholds; Sjaak Philipsen; S Pruzina; P Fraser; Frank Grosveld; G Ab
Estrogen-inducible and liver-specific expression of the chicken Very Low Density Apolipoprotein II gene locus in transgenic mice.
Nucleic acids research 1993;21(7):1629-35.
1993: Sjaak Philipsen; S Pruzina; Frank Grosveld
The minimal requirements for activity in transgenic mice of hypersensitive site 3 of the beta globin locus control region.
The EMBO journal 1993;12(3):1077-85.
1991: S Pruzina; O Hanscombe; D Whyatt; Frank Grosveld; Sjaak Philipsen
Hypersensitive site 4 of the human beta globin locus control region.
Nucleic acids research 1991;19(7):1413-9.
1990: D Talbot; Sjaak Philipsen; P Fraser; Frank Grosveld
Detailed analysis of the site 3 region of the human beta-globin dominant control region.
The EMBO journal 1990;9(7):2169-77.
1990: Sjaak Philipsen; D Talbot; P Fraser; Frank Grosveld
The beta-globin dominant control region: hypersensitive site 2.
The EMBO journal 1990;9(7):2159-67.
1990: Frank Grosveld; D Greaves; Sjaak Philipsen; D Talbot; S Pruzina; E deBoer; O Hanscombe; P Belhumeur; J Hurst; P Fraser
The dominant control region of the human beta-globin domain.
Annals of the New York Academy of Sciences 1990;612():152-9.