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John Phillips

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John D Phillips; James P Kushner; Hector A Bergonia; Michael R Franklin
Uroporphyria in the Cyp1a2-/- mouse.
Zhiwei Huang; Wei Li; Yongxiang Li; Ameeta K Agarwal; Kaifu Chen; Alice M Clark; John D Phillips; Tao Xu; Jianhuai Zhang; Xuewen Pan
Sampangine inhibits heme biosynthesis in both yeast and human.
Felipe R Lorenzo; John D Phillips; Roberto Nussenzveig; Bindu Lingam; Parvaiz Koul; Stanley L Schrier; Josef T Prchal
Molecular basis of two novel mutations found in type I methemoglobinemia.

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All Publications

2011: John D Phillips; James P Kushner; Hector A Bergonia; Michael R Franklin
Uroporphyria in the Cyp1a2-/- mouse.
Blood cells, molecules & diseases 2011;47(4):249-54.
2011: Zhiwei Huang; Wei Li; Yongxiang Li; Ameeta K Agarwal; Kaifu Chen; Alice M Clark; John D Phillips; Tao Xu; Jianhuai Zhang; Xuewen Pan
Sampangine inhibits heme biosynthesis in both yeast and human.
Eukaryotic cell 2011;10(11):1536-44.
2011: Felipe R Lorenzo; John D Phillips; Roberto Nussenzveig; Bindu Lingam; Parvaiz Koul; Stanley L Schrier; Josef T Prchal
Molecular basis of two novel mutations found in type I methemoglobinemia.
Blood cells, molecules & diseases 2011;46(4):277-81.
2010: David K Crockett; Mark M Kushnir; John D Phillips; Alan L Rockwood
Time-of-flight mass spectrometry analysis of the ferroportin-hepcidin binding domain complex for accurate mass confirmation of bioactive hepcidin 25.
Clinica chimica acta; international journal of clinical chemistry 2010;411(5-6):453-5.
2009: Melissa L Barker; Laura B Hathaway; Dorinda D Arch; Mark L Westbroek; James P Kushner; John D Phillips; Michael R Franklin
Hyper- and hypo-induction of cytochrome P450 activities with Aroclor 1254 and 3-methylcholanthrene in Cyp1a2(-/-) mice.
Chemico-biological interactions 2009;182(2-3):220-6.
2009: Huilan Lin; Damali Burton; Liangtao Li; David E Warner; John D Phillips; Diane McVey Ward; Jerry Kaplan
Gain-of-function mutations identify amino acids within transmembrane domains of the yeast vacuolar transporter Zrc1 that determine metal specificity.
The Biochemical journal 2009;422(2):273-83.
2009: John D Phillips; Christy A Warby; Frank G Whitby; James P Kushner; Christopher P Hill
Substrate shuttling between active sites of uroporphyrinogen decarboxylase is not required to generate coproporphyrinogen.
Journal of molecular biology 2009;389(2):306-14.
2009: D D Arch; L Hathaway; James P Kushner; John D Phillips; H A Bergonia; Michael R Franklin
Longitudinal study of a mouse model of familial porphyria cutanea tarda.
Cellular and molecular biology (Noisy-le-Grand, France) 2009;55(2):46-54.
2009: C A Warby; John D Phillips; Hector A Bergonia; Frank G Whitby; Christopher P Hill; James P Kushner
Structural and kinetic characterization of mutant human uroporphyrinogen decarboxylases.
Cellular and molecular biology (Noisy-le-Grand, France) 2009;55(2):40-5.
2009: Hector A Bergonia; John D Phillips; James P Kushner
Reduction of porphyrins to porphyrinogens with palladium on carbon.
Analytical biochemistry 2009;384(1):74-8.
2008: Heidi L Schubert; John D Phillips; Annie Heroux; Christopher P Hill
Structure and mechanistic implications of a uroporphyrinogen III synthase-product complex.
Biochemistry 2008;47(33):8648-55.
2008: Ivana De Domenico; Elizabeta Nemeth; Jenifer M Nelson; John D Phillips; Richard S Ajioka; Michael S Kay; James P Kushner; Tomas Ganz; Diane M Ward; Jerry Kaplan
The hepcidin-binding site on ferroportin is evolutionarily conserved.
Cell metabolism 2008;8(2):146-56.
2007: Margaret K Yu; Hector A Bergonia; Aniko Szabo; John D Phillips
Progressive disease in chronic lymphocytic leukemia is correlated with the DNA methylation index.
Leukemia research 2007;31(6):773-7.
2007: John D Phillips; Hector A Bergonia; Christopher A Reilly; Michael R Franklin; James P Kushner
A porphomethene inhibitor of uroporphyrinogen decarboxylase causes porphyria cutanea tarda.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(12):5079-84.
2007: John D Phillips; David P Steensma; Michael Allen Pulsipher; Gerald J Spangrude; James P Kushner
Congenital erythropoietic porphyria due to a mutation in GATA1: the first trans-acting mutation causative for a human porphyria.
Blood 2007;109(6):2618-21.
2007: John D Phillips; Frank G Whitby; Beth M Stadtmueller; Corwin Q Edwards; Christopher P Hill; James P Kushner
Two novel uroporphyrinogen decarboxylase (URO-D) mutations causing hepatoerythropoietic porphyria (HEP).
Translational research : the journal of laboratory and clinical medicine 2007;149(2):85-91.
2006: Richard S Ajioka; John D Phillips; James P Kushner
Biosynthesis of heme in mammals.
Biochimica et biophysica acta 2006;1763(7):723-36.
2006: Maria W Smith; Kathie-Anne Walters; Marcus J Korth; Matthew Fitzgibbon; Sean C Proll; Jill C Thompson; Matthew M Yeh; Margaret C Shuhart; Jeffrey C Furlong; Paula P Cox; David L Thomas; John D Phillips; James P Kushner; Nelson Fausto; Robert L Carithers; Michael G Katze
Gene expression patterns that correlate with hepatitis C and early progression to fibrosis in liver transplant recipients.
Gastroenterology 2006;130(1):179-87.
2005: Michael R Franklin; John D Phillips; James P Kushner
Attenuation of polychlorinated biphenyl induced uroporphyria by iron deprivation.
Environmental toxicology and pharmacology 2005;20(3):417-23.
2005: John D Phillips; James P Kushner
Fast track to the porphyrias.
Nature medicine 2005;11(10):1049-50.
2005: John D Phillips; Christy A Warby; James P Kushner
Identification of a novel mutation in the L-ferritin IRE leading to hereditary hyperferritinemia-cataract syndrome.
American journal of medical genetics. Part A 2005;134A(1):77-9.
2004: John D Phillips; Frank G Whitby; Christy A Warby; Pierre Labbe; Cheng Yang; James W Pflugrath; Joseph D Ferrara; Howard Robinson; James P Kushner; Christopher P Hill
Crystal structure of the oxygen-dependant coproporphyrinogen oxidase (Hem13p) of Saccharomyces cerevisiae.
The Journal of biological chemistry 2004;279(37):38960-8.
2003: John D Phillips; Frank G Whitby; James P Kushner; Christopher P Hill
Structural basis for tetrapyrrole coordination by uroporphyrinogen decarboxylase.
The EMBO journal 2003;22(23):6225-33.
2003: Heidi L Schubert; John D Phillips; Christopher P Hill
Structures along the catalytic pathway of PrmC/HemK, an N5-glutamine AdoMet-dependent methyltransferase.
Biochemistry 2003;42(19):5592-9.
2002: Michael R Franklin; John D Phillips; James P Kushner
Uroporphyria in the uroporphyrinogen decarboxylase-deficient mouse: Interplay with siderosis and polychlorinated biphenyl exposure.
Hepatology (Baltimore, Md.) 2002;36(4 Pt 1):805-11.
2002: Heidi L Schubert; Evelyne Raux; M A A Matthews; John D Phillips; Keith S Wilson; Christopher P Hill; Martin J Warren
Structural diversity in metal ion chelation and the structure of uroporphyrinogen III synthase.
Biochemical Society transactions 2002;30(4):595-600.
2002: Frank G Whitby; John D Phillips; Christopher P Hill; William McCoubrey; Mahin D Maines
Crystal structure of a biliverdin IXalpha reductase enzyme-cofactor complex.
Journal of molecular biology 2002;319(5):1199-210.
2001: John D Phillips; T L Parker; Heidi L Schubert; Frank G Whitby; Christopher P Hill; James P Kushner
Functional consequences of naturally occurring mutations in human uroporphyrinogen decarboxylase.
Blood 2001;98(12):3179-85.
2001: Michael A A Mathews; Heidi L Schubert; Frank G Whitby; K J Alexander; K Schadick; Hector A Bergonia; John D Phillips; Christopher P Hill
Crystal structure of human uroporphyrinogen III synthase.
The EMBO journal 2001;20(21):5832-9.
2001: John D Phillips; James P Kushner
Measurement of uroporphyrinogen decarboxylase activity.
Current protocols in toxicology / editorial board, Mahin D. Maines (editor-in-chief) ... [et al.] 2001;Chapter 8():Unit 8.4.
2001: John D Phillips; James P Kushner
The heme biosynthesis pathway and clinical manifestations of abnormal function.
Current protocols in toxicology / editorial board, Mahin D. Maines (editor-in-chief) ... [et al.] 2001;Chapter 8():Unit 8.1.
2001: John D Phillips; L K Jackson; Michaeline Bunting; Michael R Franklin; Kirk R Thomas; Joanne E Levy; Nancy C Andrews; James P Kushner
A mouse model of familial porphyria cutanea tarda.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(1):259-64.
2001: Michael R Franklin; John D Phillips; James P Kushner
Accelerated development of uroporphyria in mice heterozygous for a deletion at the uroporphyrinogen decarboxylase locus.
Journal of biochemical and molecular toxicology 2001;15(5):287-93.
2000: ZJ Bulaj; Michael R Franklin; John D Phillips; K L Miller; Hector A Bergonia; Richard S Ajioka; LM Griffen; D J Guinee; Corwin Q Edwards; James P Kushner
Transdermal estrogen replacement therapy in postmenopausal women previously treated for porphyria cutanea tarda.
The Journal of laboratory and clinical medicine 2000;136(6):482-8.
2000: ZJ Bulaj; Richard S Ajioka; John D Phillips; Bernie LaSalle; Lynn B Jorde; LM Griffen; Corwin Q Edwards; James P Kushner
Disease-related conditions in relatives of patients with hemochromatosis.
The New England journal of medicine 2000;343(21):1529-35.
2000: Michael R Franklin; John D Phillips; James P Kushner
CYP3A-inducing agents and the attenuation of uroporphyrin accumulation and excretion in a rat model of porphyria cutanea tarda.
Biochemical pharmacology 2000;60(9):1325-31.
2000: ZJ Bulaj; John D Phillips; Richard S Ajioka; Michael R Franklin; LM Griffen; D J Guinee; Corwin Q Edwards; James P Kushner
Hemochromatosis genes and other factors contributing to the pathogenesis of porphyria cutanea tarda.
Blood 2000;95(5):1565-71.
1998: Frank G Whitby; John D Phillips; James P Kushner; Christopher P Hill
Crystal structure of human uroporphyrinogen decarboxylase.
The EMBO journal 1998;17(9):2463-71.
1997: Michael R Franklin; John D Phillips; James P Kushner
Cytochrome P450 induction, uroporphyrinogen decarboxylase depression, porphyrin accumulation and excretion, and gender influence in a 3-week rat model of porphyria cutanea tarda.
Toxicology and applied pharmacology 1997;147(2):289-99.
1997: Frank G Whitby; Hartmut Luecke; P Kuhn; John R Somoza; J A Huete-Perez; John D Phillips; Christopher P Hill; Robert J Fletterick; Ching C Wang
Crystal structure of Tritrichomonas foetus inosine-5'-monophosphate dehydrogenase and the enzyme-product complex.
Biochemistry 1997;36(35):10666-74.
1997: John D Phillips; Frank G Whitby; James P Kushner; Christopher P Hill
Characterization and crystallization of human uroporphyrinogen decarboxylase.
Protein science : a publication of the Protein Society 1997;6(6):1343-6.
1996: E E Wyckoff; John D Phillips; A M Sowa; Michael R Franklin; James P Kushner
Mutational analysis of human uroporphyrinogen decarboxylase.
Biochimica et biophysica acta 1996;1298(2):294-304.