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Margaret Phillips

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TOP 3
Margaret A Phillips
Stoking the drug target pipeline for human African trypanosomiasis.
Liang Zhang; Ling Cai; Priyabrata Das; Jef de Brabander; Xiaoyi Deng; Christian V Forst; Adolfo García-Sastre; David E Levy; Balaji Manicassamy; Margaret A Phillips; Michael Roth; Mirco Schmolke; Benjamin P Tu; Yaming Wang; Beatriz M A Fontoura
Inhibition of pyrimidine synthesis reverses viral virulence factor-mediated block of mRNA nuclear export.
Erin Willert; Margaret A Phillips
Regulation and function of polyamines in African trypanosomes.

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All Publications

2012: Margaret A Phillips
Stoking the drug target pipeline for human African trypanosomiasis.
Molecular microbiology 2012;86(1):10-4.
2012: Liang Zhang; Ling Cai; Priyabrata Das; Jef de Brabander; Xiaoyi Deng; Christian V Forst; Adolfo García-Sastre; David E Levy; Balaji Manicassamy; Margaret A Phillips; Michael Roth; Mirco Schmolke; Benjamin P Tu; Yaming Wang; Beatriz M A Fontoura
Inhibition of pyrimidine synthesis reverses viral virulence factor-mediated block of mRNA nuclear export.
The Journal of cell biology 2012;196(3):315-26.
2012: Erin Willert; Margaret A Phillips
Regulation and function of polyamines in African trypanosomes.
Trends in parasitology 2012;28(2):66-72.
2011: Savitha Kalidas; Qiong Li; Margaret A Phillips
A Gateway® compatible vector for gene silencing in bloodstream form Trypanosoma brucei.
Molecular and biochemical parasitology 2011;178(1-2):51-5.
2011: Erin Willert; Lisa N Kinch; Margaret A Phillips
Identification and assay of allosteric regulators of S-adenosylmethionine decarboxylase.
Methods in molecular biology (Clifton, N.J.) 2011;720():219-35.
2010: Margaret A Phillips; Pradipsinh K Rathod
Plasmodium dihydroorotate dehydrogenase: a promising target for novel anti-malarial chemotherapy.
Infectious disorders drug targets 2010;10(3):226-39.
2009: Erin Willert; Margaret A Phillips
Cross-species activation of trypanosome S-adenosylmethionine decarboxylase by the regulatory subunit prozyme.
Molecular and biochemical parasitology 2009;168(1):1-6.
2009: Xiaoyi Deng; Ramesh Gujjar; Farah El Mazouni; Werner Kaminsky; Nicholas A Malmquist; Elizabeth J Goldsmith; Pradipsinh K Rathod; Margaret A Phillips
Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds.
The Journal of biological chemistry 2009;284(39):26999-7009.
2009: Yanjing Xiao; Diane E McCloskey; Margaret A Phillips
RNA interference-mediated silencing of ornithine decarboxylase and spermidine synthase genes in Trypanosoma brucei provides insight into regulation of polyamine biosynthesis.
Eukaryotic cell 2009;8(5):747-55.
2009: Jeongmi Lee; Vanessa Sperandio; Doug E Frantz; Jamie Longgood; Andrew Camilli; Margaret A Phillips; Anthony J Michael
An alternative polyamine biosynthetic pathway is widespread in bacteria and essential for biofilm formation in Vibrio cholerae.
The Journal of biological chemistry 2009;284(15):9899-907.
2008: Erin Willert; Margaret A Phillips
Regulated expression of an essential allosteric activator of polyamine biosynthesis in African trypanosomes.
PLoS pathogens 2008;4(10):e1000183.
2008: Margaret A Phillips; Ramesh Gujjar; Nicholas A Malmquist; John White; Farah El Mazouni; Jeffrey Baldwin; Pradipsinh K Rathod
Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum.
Journal of medicinal chemistry 2008;51(12):3649-53.
2008: Nicholas A Malmquist; Ramesh Gujjar; Pradipsinh K Rathod; Margaret A Phillips
Analysis of flavin oxidation and electron-transfer inhibition in Plasmodium falciparum dihydroorotate dehydrogenase.
Biochemistry 2008;47(8):2466-75.
2007: Jeongmi Lee; Anthony J Michael; Dariusz Martynowski; Elizabeth J Goldsmith; Margaret A Phillips
Phylogenetic diversity and the structural basis of substrate specificity in the beta/alpha-barrel fold basic amino acid decarboxylases.
The Journal of biological chemistry 2007;282(37):27115-25.
2007: Melissa J Rodgers; Joseph P Albanesi; Margaret A Phillips
Phosphatidylinositol 4-kinase III-beta is required for Golgi maintenance and cytokinesis in Trypanosoma brucei.
Eukaryotic cell 2007;6(7):1108-18.
2007: Erin Willert; Richard Fitzpatrick; Margaret A Phillips
Allosteric regulation of an essential trypanosome polyamine biosynthetic enzyme by a catalytically dead homolog.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(20):8275-80.
2007: Nicholas A Malmquist; Jeffrey Baldwin; Margaret A Phillips
Detergent-dependent kinetics of truncated Plasmodium falciparum dihydroorotate dehydrogenase.
The Journal of biological chemistry 2007;282(17):12678-86.
2007: Rahul Shah; Radha Akella; Elizabeth J Goldsmith; Margaret A Phillips
X-ray structure of Paramecium bursaria Chlorella virus arginine decarboxylase: insight into the structural basis for substrate specificity.
Biochemistry 2007;46(10):2831-41.
2006: Tracy Clyne Beswick; Erin Willert; Margaret A Phillips
Mechanisms of allosteric regulation of Trypanosoma cruzi S-adenosylmethionine decarboxylase.
Biochemistry 2006;45(25):7797-807.
2005: Jeffrey Baldwin; Carolyn H Michnoff; Nicholas A Malmquist; John White; Michael Roth; Pradipsinh K Rathod; Margaret A Phillips
High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase.
The Journal of biological chemistry 2005;280(23):21847-53.
2004: Laurie K Jackson; Jeffrey Baldwin; Radha Akella; Elizabeth J Goldsmith; Margaret A Phillips
Multiple active site conformations revealed by distant site mutation in ornithine decarboxylase.
Biochemistry 2004;43(41):12990-9.
2004: Rahul Shah; Catherine S Coleman; Kiran Mir; Jeffrey Baldwin; James L Van Etten; Nick V Grishin; Anthony E Pegg; Bruce Stanley; Margaret A Phillips
Paramecium bursaria chlorella virus-1 encodes an unusual arginine decarboxylase that is a close homolog of eukaryotic ornithine decarboxylases.
The Journal of biological chemistry 2004;279(34):35760-7.
2004: S Kumar Singh; Kun Yang; Subburamu Karthikeyan; Tu Huynh; Xuejun Zhang; Margaret A Phillips; Hong Zhang
The thrH gene product of Pseudomonas aeruginosa is a dual activity enzyme with a novel phosphoserine:homoserine phosphotransferase activity.
The Journal of biological chemistry 2004;279(13):13166-73.
2003: Tu T Huynh; Van T Huynh; Margaret Harmon; Margaret A Phillips
Gene knockdown of gamma-glutamylcysteine synthetase by RNAi in the parasitic protozoa Trypanosoma brucei demonstrates that it is an essential enzyme.
The Journal of biological chemistry 2003;278(41):39794-800.
2003: Laurie K Jackson; Elizabeth J Goldsmith; Margaret A Phillips
X-ray structure determination of Trypanosoma brucei ornithine decarboxylase bound to D-ornithine and to G418: insights into substrate binding and ODC conformational flexibility.
The Journal of biological chemistry 2003;278(24):22037-43.
2003: Pradipsinh K Rathod; Margaret A Phillips
Prized malaria drug target nailed.
Nature structural biology 2003;10(5):316-8.
2003: Laurie K Jackson; Harold B Brooks; David P Myers; Margaret A Phillips
Ornithine decarboxylase promotes catalysis by binding the carboxylate in a buried pocket containing phenylalanine 397.
Biochemistry 2003;42(10):2933-40.
2002: Tracy Clyne; Lisa N Kinch; Margaret A Phillips
Putrescine activation of Trypanosoma cruzi S-adenosylmethionine decarboxylase.
Biochemistry 2002;41(44):13207-16.
2002: Jeffrey Baldwin; Azizeh M Farajallah; Nicholas A Malmquist; Pradipsinh K Rathod; Margaret A Phillips
Malarial dihydroorotate dehydrogenase. Substrate and inhibitor specificity.
The Journal of biological chemistry 2002;277(44):41827-34.
2002: Laurie K Jackson; Margaret A Phillips
Target validation for drug discovery in parasitic organisms.
Current topics in medicinal chemistry 2002;2(5):425-38.
2002: Jared J Abbott; Jennifer L Ford; Margaret A Phillips
Substrate binding determinants of Trypanosoma brucei gamma-glutamylcysteine synthetase.
Biochemistry 2002;41(8):2741-50.
2001: Jared J Abbott; J Pei; J L Ford; Y Qi; V N Grishin; Lisa A Pitcher; Margaret A Phillips; Nick V Grishin
Structure prediction and active site analysis of the metal binding determinants in gamma -glutamylcysteine synthetase.
The Journal of biological chemistry 2001;276(45):42099-107.
2001: David P Myers; Laurie K Jackson; V G Ipe; G E Murphy; Margaret A Phillips
Long-range interactions in the dimer interface of ornithine decarboxylase are important for enzyme function.
Biochemistry 2001;40(44):13230-6.
2000: Laurie K Jackson; Harold B Brooks; Andrei Osterman; Elizabeth J Goldsmith; Margaret A Phillips
Altering the reaction specificity of eukaryotic ornithine decarboxylase.
Biochemistry 2000;39(37):11247-57.
2000: Lisa N Kinch; Margaret A Phillips
Single-turnover kinetic analysis of Trypanosoma cruzi S-adenosylmethionine decarboxylase.
Biochemistry 2000;39(12):3336-43.
1999: Nick V Grishin; Andrei Osterman; Harold B Brooks; Margaret A Phillips; Elizabeth J Goldsmith
X-ray structure of ornithine decarboxylase from Trypanosoma brucei: the native structure and the structure in complex with alpha-difluoromethylornithine.
Biochemistry 1999;38(46):15174-84.
1999: Andrei Osterman; Harold B Brooks; L Jackson; Jared J Abbott; Margaret A Phillips
Lysine-69 plays a key role in catalysis by ornithine decarboxylase through acceleration of the Schiff base formation, decarboxylation, and product release steps.
Biochemistry 1999;38(36):11814-26.
1999: Lisa N Kinch; J R Scott; Buddy Ullman; Margaret A Phillips
Cloning and kinetic characterization of the Trypanosoma cruzi S-adenosylmethionine decarboxylase.
Molecular and biochemical parasitology 1999;101(1-2):1-11.
1998: T Swanson; Harold B Brooks; Andrei Osterman; M H O'Leary; Margaret A Phillips
Carbon-13 isotope effect studies of Trypanosoma brucei ornithine decarboxylase.
Biochemistry 1998;37(42):14943-7.
1998: Deirdre L Brekken; Margaret A Phillips
Trypanosoma brucei gamma-glutamylcysteine synthetase. Characterization of the kinetic mechanism and the role of Cys-319 in cystamine inactivation.
The Journal of biological chemistry 1998;273(41):26317-22.
1997: Harold B Brooks; Margaret A Phillips
Characterization of the reaction mechanism for Trypanosoma brucei ornithine decarboxylase by multiwavelength stopped-flow spectroscopy.
Biochemistry 1997;36(49):15147-55.
1997: Margaret Harmon; T C Scott; Y Li; M F Boehm; Margaret A Phillips; David J Mangelsdorf
Trypanosoma brucei: effects of methoprene and other isoprenoid compounds on procyclic and bloodstream forms in vitro and in mice.
Experimental parasitology 1997;87(3):229-36.
1997: T C Scott; Margaret A Phillips
Characterization of Trypanosoma brucei pyridoxal kinase: purification, gene isolation and expression in Escherichia coli.
Molecular and biochemical parasitology 1997;88(1-2):1-11.
1997: Andrei Osterman; Harold B Brooks; Josep Rizo; Margaret A Phillips
Role of Arg-277 in the binding of pyridoxal 5'-phosphate to Trypanosoma brucei ornithine decarboxylase.
Biochemistry 1997;36(15):4558-67.
1996: D V Lueder; Margaret A Phillips
Characterization of Trypanosoma brucei gamma-glutamylcysteine synthetase, an essential enzyme in the biosynthesis of trypanothione (diglutathionylspermidine).
The Journal of biological chemistry 1996;271(29):17485-90.
1996: Harold B Brooks; Margaret A Phillips
Circular dichroism assay for decarboxylation of optically pure amino acids: application to ornithine decarboxylase.
Analytical biochemistry 1996;238(2):191-4.
1996: Margaret A Phillips; W J Rutter
Role of the prodomain in folding and secretion of rat pancreatic carboxypeptidase A1.
Biochemistry 1996;35(21):6771-6.
1996: Nick V Grishin; Andrei Osterman; Elizabeth J Goldsmith; Margaret A Phillips
Crystallization and preliminary X-ray studies of ornithine decarboxylase from Trypanosoma brucei.
Proteins 1996;24(2):272-3.
1995: Andrei Osterman; D V Lueder; M Quick; D Myers; BJ Canagarajah; Margaret A Phillips
Domain organization and a protease-sensitive loop in eukaryotic ornithine decarboxylase.
Biochemistry 1995;34(41):13431-6.
1995: Nick V Grishin; Margaret A Phillips; Elizabeth J Goldsmith
Modeling of the spatial structure of eukaryotic ornithine decarboxylases.
Protein science : a publication of the Protein Society 1995;4(7):1291-304.
1995: Andrei Osterman; L N Kinch; Nick V Grishin; Margaret A Phillips
Acidic residues important for substrate binding and cofactor reactivity in eukaryotic ornithine decarboxylase identified by alanine scanning mutagenesis.
The Journal of biological chemistry 1995;270(20):11797-802.
1994: Nick V Grishin; Margaret A Phillips
The subunit interfaces of oligomeric enzymes are conserved to a similar extent to the overall protein sequences.
Protein science : a publication of the Protein Society 1994;3(12):2455-8.
1994: Andrei Osterman; Nick V Grishin; L N Kinch; Margaret A Phillips
Formation of functional cross-species heterodimers of ornithine decarboxylase.
Biochemistry 1994;33(46):13662-7.
1994: David R Corey; Margaret A Phillips
Cyclic peptides as proteases: a reevaluation.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(10):4106-9.