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Robert Phillips

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TOP 3
Austin P Harris; Robert S Phillips
Benzimidazole analogs of (L)-tryptophan are substrates and inhibitors of tryptophan indole lyase from Escherichia coli.
Renuka Kadirvelraj; Robert S Phillips; Nicholas C Sennett; Gregory S Custer; Zachary A Wood
Hysteresis and negative cooperativity in human UDP-glucose dehydrogenase.
Robert S Phillips; Susan Busby; Leia Edenfield; Kevin Wickware
Preparation of 3-bromo-L-tyrosine and 3,5-dibromo-L-tyrosine.

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All Publications

2013: Austin P Harris; Robert S Phillips
Benzimidazole analogs of (L)-tryptophan are substrates and inhibitors of tryptophan indole lyase from Escherichia coli.
The FEBS journal 2013;280(8):1807-17.
2013: Renuka Kadirvelraj; Robert S Phillips; Nicholas C Sennett; Gregory S Custer; Zachary A Wood
Hysteresis and negative cooperativity in human UDP-glucose dehydrogenase.
Biochemistry 2013;52(8):1456-65.
2013: Robert S Phillips; Susan Busby; Leia Edenfield; Kevin Wickware
Preparation of 3-bromo-L-tyrosine and 3,5-dibromo-L-tyrosine.
Amino acids 2013;44(2):529-32.
2012: Robert S Phillips; Alexandre Kim Wang; Stephane Marchal; Reinhard Lange
Effects of pressure and osmolytes on the allosteric equilibria of Salmonella typhimurium tryptophan synthase.
Biochemistry 2012;51(46):9354-63.
2012: Robert S Phillips; Ukoha Kalu; Sam Hay
Evidence of preorganization in quinonoid intermediate formation from L-Trp in H463F mutant Escherichia coli tryptophan indole-lyase from effects of pressure and pH.
Biochemistry 2012;51(33):6527-33.
2012: Chandan Maitrani; Selvanathan Arumugam; Sam Hay; Derren J Heyes; Vladimir V Popik; Robert S Phillips
Preparation and photophysical properties of a caged kynurenine.
Bioorganic & medicinal chemistry letters 2012;22(8):2734-7.
2011: Yi Zhang; Xavier Jeunemaitre; Xueya Zhou; Jie Shen; Robert S Phillips; Shengnan Wu; Kuixing Zhang; Pingjin Gao; Bing Xiao; Xin He; Dingliang Zhu
A rare variant at the KYNU gene is associated with kynureninase activity and essential hypertension in the Han Chinese population.
Circulation. Cardiovascular genetics 2011;4(6):687-94.
2011: Robert S Phillips
Structure, mechanism, and substrate specificity of kynureninase.
Biochimica et biophysica acta 2011;1814(11):1481-8.
2011: Dalibor Milić; Robert S Phillips; Tatyana V Demidkina; Nicolai G Faleev; Dubravka Matković-Čalogović; Alfred A Antson
Crystallographic snapshots of tyrosine phenol-lyase show that substrate strain plays a role in C-C bond cleavage.
Journal of the American Chemical Society 2011;133(41):16468-76.
2011: Robert S Phillips; Rashin Ghaffari; Peter Dinh; Santiago Lima; Douglas Bartlett
Properties of tryptophan indole-lyase from a piezophilic bacterium, Photobacterium profundum SS9.
Archives of biochemistry and biophysics 2011;506(1):35-41.
2010: Sunil Kumar; Vijay B Gawandi; Nicholas Capito; Robert S Phillips
Substituent effects on the reaction of beta-benzoylalanines with Pseudomonas fluorescens kynureninase.
Biochemistry 2010;49(36):7913-9.
2010: Robert S Phillips; Santiago Lima; Roman Khristoforov; Bakthavatsalam Sudararaju
Insights into the mechanism of Pseudomonas dacunhae aspartate beta-decarboxylase from rapid-scanning stopped-flow kinetics.
Biochemistry 2010;49(24):5066-73.
2010: John M Brewer; Jared S McKinnon; Robert S Phillips
Stopped-flow studies of the reaction of D-tartronate semialdehyde-2-phosphate with human neuronal enolase and yeast enolase 1.
FEBS letters 2010;584(5):979-83.
2010: Robert S Phillips; Edith W Miles; Peter McPhie; Stephane Marchal; Reinhard Lange; Georg Holtermann; Roger S Goody
Effects of hydrostatic pressure on the conformational equilibrium of tryptophan synthase from Salmonella typhimurium.
Annals of the New York Academy of Sciences 2010;1189():95-103.
2009: Nicolai G Faleev; Kirill V Alferov; Marina A Tsvetikova; Elena A Morozova; SV Revtovich; EN Khurs; Mikhail M Vorob'ev; Robert S Phillips; Tatyana V Demidkina; RM Khomutov
Methionine gamma-lyase: mechanistic deductions from the kinetic pH-effects. The role of the ionic state of a substrate in the enzymatic activity.
Biochimica et biophysica acta 2009;1794(10):1414-20.
2009: Stéphane Marchal; Josep Font Sadurni; Marc Ribo; Maria Vilanova; Robert S Phillips; Reinhard Lange; Joan Torrent
Asymmetric kinetics of protein structural changes.
Accounts of chemical research 2009;42(6):778-87.
2009: Santiago Lima; Bakthavatsalam Sundararaju; Christina Huang; Roman Khristoforov; Cory Momany; Robert S Phillips
The crystal structure of the Pseudomonas dacunhae aspartate-beta-decarboxylase dodecamer reveals an unknown oligomeric assembly for a pyridoxal-5'-phosphate-dependent enzyme.
Journal of molecular biology 2009;388(1):98-108.
2009: T V Demidkina; A A Anston; N G Faleev; Robert S Phillips; L N Zakomyrdina
[Spatial structure and mechanism of tyrosine phenol-lyase and tryptophan indole-lyase].
Molekuliarnaia biologiia 2009;43(2):295-308.
2009: Santiago Lima; Sunil Kumar; Vijay Gawandi; Cory Momany; Robert S Phillips
Crystal structure of the Homo sapiens kynureninase-3-hydroxyhippuric acid inhibitor complex: insights into the molecular basis of kynureninase substrate specificity.
Journal of medicinal chemistry 2009;52(2):389-96.
2009: Anna Kogan; Garik Y Gdalevsky; Rivka Cohen-Luria; Yehuda Goldgur; Robert S Phillips; Abraham H Parola; Orna Almog
Conformational changes and loose packing promote E. coli Tryptophanase cold lability.
BMC structural biology 2009;9():65.
2008: Karen R Crozier-Reabe; Robert S Phillips; Graham R Moran
Kynurenine 3-monooxygenase from Pseudomonas fluorescens: substrate-like inhibitors both stimulate flavin reduction and stabilize the flavin-peroxo intermediate yet result in the production of hydrogen peroxide.
Biochemistry 2008;47(47):12420-33.
2008: Andrew S Osborne; Phanneth Som; Jessica L Metcalf; Robert S Phillips
Regioselective nitration of N(alpha),N(1)-bis(trifluoroacetyl)-L-tryptophan methyl ester: efficient synthesis of 2-nitro and 6-nitro-N-trifluoroacetyl-L-tryptophan methyl ester.
Bioorganic & medicinal chemistry letters 2008;18(21):5750-2.
2008: Robert S Phillips; Edith W Miles; Peter McPhie; Stephane Marchal; Cédric Georges; Yves Dupont; Reinhard Lange
Pressure and temperature jump relaxation kinetics of the conformational change in Salmonella typhimurium tryptophan synthase L-serine complex: large activation compressibility and heat capacity changes demonstrate the contribution of solvation.
Journal of the American Chemical Society 2008;130(41):13580-8.
2008: Musa Musa; Karla I Ziegelmann-Fjeld; Claire Vieille; Robert S Phillips
Activity and selectivity of W110A secondary alcohol dehydrogenase from Thermoanaerobacter ethanolicus in organic solvents and ionic liquids: mono- and biphasic media.
Organic & biomolecular chemistry 2008;6(5):887-92.
2008: Robert S Phillips; Peter McPhie; Edith Wilson Miles; Stéphane Marchal; Reinhard Lange
Quantitative effects of allosteric ligands and mutations on conformational equilibria in Salmonella typhimurium tryptophan synthase.
Archives of biochemistry and biophysics 2008;470(1):8-19.
2007: Walter De Laurentis; Leang Khim; J L Ross Anderson; Ariane Adam; Kenneth Alan Johnson; Robert S Phillips; Stephen K Chapman; Karl-Heinz van Pee; James H Naismith
The second enzyme in pyrrolnitrin biosynthetic pathway is related to the heme-dependent dioxygenase superfamily.
Biochemistry 2007;46(43):12393-404.
2007: Lingyun Song; Quincy Teng; Robert S Phillips; John M Brewer; Anne O Summers
19F-NMR reveals metal and operator-induced allostery in MerR.
Journal of molecular biology 2007;371(1):79-92.
2007: Santiago Lima; Roman Khristoforov; Cory Momany; Robert S Phillips
Crystal structure of Homo sapiens kynureninase.
Biochemistry 2007;46(10):2735-44.
2007: Karla I Ziegelmann-Fjeld; Musa Musa; Robert S Phillips; J Gregory Zeikus; Claire Vieille
A Thermoanaerobacter ethanolicus secondary alcohol dehydrogenase mutant derivative highly active and stereoselective on phenylacetone and benzylacetone.
Protein engineering, design & selection : PEDS 2007;20(2):47-55.
2007: Musa Musa; Karla I Ziegelmann-Fjeld; Claire Vieille; J Gregory Zeikus; Robert S Phillips
Asymmetric reduction and oxidation of aromatic ketones and alcohols using W110A secondary alcohol dehydrogenase from Thermoanaerobacter ethanolicus.
The Journal of organic chemistry 2007;72(1):30-4.
2007: Musa Musa; Karla I Ziegelmann-Fjeld; Claire Vieille; J Gregory Zeikus; Robert S Phillips
Xerogel-encapsulated W110A secondary alcohol dehydrogenase from Thermoanaerobacter ethanolicus performs asymmetric reduction of hydrophobic ketones in organic solvents.
Angewandte Chemie (International ed. in English) 2007;46(17):3091-4.
2007: Anthony Collet; Sébastien Vilain; Pascal Cosette; Guy-Alain Junter; THIERRY JOUENNE; Robert S Phillips; Patrick Di Martino
Protein expression in Escherichia coli S17-1 biofilms: impact of indole.
Antonie van Leeuwenhoek 2007;91(1):71-85.
2006: Amparo Lima; Santiago Lima; Joshua H Wong; Robert S Phillips; Bob B Buchanan; Sheng Luan
A redox-active FKBP-type immunophilin functions in accumulation of the photosystem II supercomplex in Arabidopsis thaliana.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(33):12631-6.
2006: Robert S Phillips; Hao Yuan Chen; Nicolai G Faleev
Aminoacrylate intermediates in the reaction of Citrobacter freundii tyrosine phenol-lyase.
Biochemistry 2006;45(31):9575-83.
2006: Tatyana V Demidkina; Nicolai G Faleev; AI Papisova; NP Bazhulina; Vitalia V Kulikova; Paul Gollnick; Robert S Phillips
Aspartic acid 214 in Citrobacter freundii tyrosine phenol-lyase ensures sufficient C--H-acidity of the external aldimine intermediate and proper orientation of the cofactor at the active site.
Biochimica et biophysica acta 2006;1764(7):1268-76.
2006: Hilda Hernandez; Sarah Niehauser; Stacey A Boltz; Vijay Gawandi; Robert S Phillips; I Jonathan Amster
Mass defect labeling of cysteine for improving peptide assignment in shotgun proteomic analyses.
Analytical chemistry 2006;78(10):3417-23.
2006: Vitalia V Kulikova; Lyudmila N Zakomirdina; Irene S Dementieva; Robert S Phillips; Paul Gollnick; Tatyana V Demidkina; Nicolai G Faleev
Tryptophanase from Proteus vulgaris: the conformational rearrangement in the active site, induced by the mutation of Tyrosine 72 to phenylalanine, and its mechanistic consequences.
Biochimica et biophysica acta 2006;1764(4):750-7.
2006: Klaus D Schnackerz; John Keller; Robert S Phillips; Michael D Toney
Ionization state of pyridoxal 5'-phosphate in D-serine dehydratase, dialkylglycine decarboxylase and tyrosine phenol-lyase and the influence of monovalent cations as inferred by 31P NMR spectroscopy.
Biochimica et biophysica acta 2006;1764(2):230-8.
2006: Chunyan Li; Vijay Gawandi; Adam Protos; Robert S Phillips; I Jonathan Amster
A matrix-assisted laser desorption/ionization compatible reagent for tagging tryptophan residues.
European journal of mass spectrometry (Chichester, England) 2006;12(4):213-21.
2005: Robert S Phillips; Georg Holtermann
Differential effects of temperature and hydrostatic pressure on the formation of quinonoid intermediates from L-Trp and L-Met by H463F mutant Escherichia coli tryptophan indole-lyase.
Biochemistry 2005;44(43):14289-97.
2005: Michael T Cash; Peter R Schreiner; Robert S Phillips
Excited state tautomerization of azaindole.
Organic & biomolecular chemistry 2005;3(20):3701-6.
2005: Robert S Phillips; Edith Wilson Miles; Georg Holtermann; Roger S Goody
Hydrostatic pressure affects the conformational equilibrium of Salmonella typhimurium tryptophan synthase.
Biochemistry 2005;44(21):7921-8.
2004: Michael T Cash; Edith Wilson Miles; Robert S Phillips
The reaction of indole with the aminoacrylate intermediate of Salmonella typhimurium tryptophan synthase: observation of a primary kinetic isotope effect with 3-[(2)H]indole.
Archives of biochemistry and biophysics 2004;432(2):233-43.
2004: Robert S Phillips; Hao Yuan Chen; David Shim; Santiago Lima; Khadijeh Tavakoli; Bakthavatsalam Sundararaju
Role of lysine-256 in Citrobacter freundii tyrosine phenol-lyase in monovalent cation activation.
Biochemistry 2004;43(45):14412-9.
2004: Nicolai G Faleev; Tatyana V Demidkina; Marina A Tsvetikova; Robert S Phillips; Igor A Yamskov
The mechanism of alpha-proton isotope exchange in amino acids catalysed by tyrosine phenol-lyase. What is the role of quinonoid intermediates?
European journal of biochemistry / FEBS 2004;271(22):4565-71.
2004: M Carmen Galan; Andre Venot; Robert S Phillips; Gerardus Josephus Boons
The design and synthesis of a selective inhibitor of fucosyltransferase VI.
Organic & biomolecular chemistry 2004;2(9):1376-80.
2004: Barbara Pioselli; Stefano Bettati; Tatyana V Demidkina; Lyudmila N Zakomirdina; Robert S Phillips; Andrea Mozzarelli
Tyrosine phenol-lyase and tryptophan indole-lyase encapsulated in wet nanoporous silica gels: Selective stabilization of tertiary conformations.
Protein science : a publication of the Protein Society 2004;13(4):913-24.
2004: Vijay Gawandi; Diane Liskey; Santiago Lima; Robert S Phillips
Reaction of Pseudomonas fluorescens kynureninase with beta-benzoyl-L-alanine: detection of a new reaction intermediate and a change in rate-determining step.
Biochemistry 2004;43(11):3230-7.
2004: Cory Momany; Vladimir M Levdikov; Lena Blagova; Santiago Lima; Robert S Phillips
Three-dimensional structure of kynureninase from Pseudomonas fluorescens.
Biochemistry 2004;43(5):1193-203.
2004: Todd J Clark; Robert S Phillips; Becky M Bundy; Cory Momany; Ellen Neidle
Benzoate decreases the binding of cis,cis-muconate to the BenM regulator despite the synergistic effect of both compounds on transcriptional activation.
Journal of bacteriology 2004;186(4):1200-4.
2003: Zanna Beharry; D Matthew Eby; Eric D Coulter; Rathinam Viswanathan; Ellen Neidle; Robert S Phillips; Donald M Kurtz
Histidine ligand protonation and redox potential in the rieske dioxygenases: role of a conserved aspartate in anthranilate 1,2-dioxygenase.
Biochemistry 2003;42(46):13625-36.
2003: Andrew Osborne; Quincy Teng; Edith Wilson Miles; Robert S Phillips
Detection of open and closed conformations of tryptophan synthase by 15N-heteronuclear single-quantum coherence nuclear magnetic resonance of bound 1-15N-L-tryptophan.
The Journal of biological chemistry 2003;278(45):44083-90.
2003: Joseph P Emerson; Eric D Coulter; Robert S Phillips; Donald M Kurtz
Kinetics of the superoxide reductase catalytic cycle.
The Journal of biological chemistry 2003;278(41):39662-8.
2003: Tatyana V Demidkina; Lyudmila N Zakomirdina; Vitalia V Kulikova; Irene S Dementieva; Nicolai G Faleev; Luca Ronda; Andrea Mozzarelli; Paul Gollnick; Robert S Phillips
Role of aspartate-133 and histidine-458 in the mechanism of tryptophan indole-lyase from Proteus vulgaris.
Biochemistry 2003;42(38):11161-9.
2003: P Di Martino; R Fursy; L Bret; B Sundararaju; Robert S Phillips
Indole can act as an extracellular signal to regulate biofilm formation of Escherichia coli and other indole-producing bacteria.
Canadian journal of microbiology 2003;49(7):443-9.
2003: Nicolai G Faleev; Olga V Axenova; Tatyana V Demidkina; Robert S Phillips
The role of acidic dissociation of substrate's phenol group in the mechanism of tyrosine phenol-lyase.
Biochimica et biophysica acta 2003;1647(1-2):260-5.
2003: Robert S Phillips; Tatyana V Demidkina; Nicolai G Faleev
Structure and mechanism of tryptophan indole-lyase and tyrosine phenol-lyase.
Biochimica et biophysica acta 2003;1647(1-2):167-72.
2003: Christian Heiss; Jay Anderson; Robert S Phillips
Differential effects of bromination on substrates and inhibitors of kynureninase from Pseudomonas fluorescens.
Organic & biomolecular chemistry 2003;1(2):288-95.
2002: Robert S Phillips; Tatyana V Demidkina; Lyudmila N Zakomirdina; Stefano Bruno; Luca Ronda; Andrea Mozzarelli
Crystals of tryptophan indole-lyase and tyrosine phenol-lyase form stable quinonoid complexes.
The Journal of biological chemistry 2002;277(24):21592-7.
2002: Tatyana V Demidkina; Maria V Barbolina; Nicolai G Faleev; Bakthavatsalam Sundararaju; Paul Gollnick; Robert S Phillips
Threonine-124 and phenylalanine-448 in Citrobacter freundii tyrosine phenol-lyase are necessary for activity with L-tyrosine.
The Biochemical journal 2002;363(Pt 3):745-52.
2002: Joseph P Emerson; Eric D Coulter; Diane E Cabelli; Robert S Phillips; Donald M Kurtz
Kinetics and mechanism of superoxide reduction by two-iron superoxide reductase from Desulfovibrio vulgaris.
Biochemistry 2002;41(13):4348-57.
2002: Robert S Phillips; Nancy Johnson; Ajith V Kamath
Formation in vitro of hybrid dimers of H463F and Y74F mutant Escherichia coli tryptophan indole-lyase rescues activity with L-tryptophan.
Biochemistry 2002;41(12):4012-9.
2002: Tali Erez; Garik Y Gdalevsky; Chithra Hariharan; Dina Pines; Ehud Pines; Robert S Phillips; Rivka Cohen-Luria; Abraham H Parola
Cold-induced enzyme inactivation: how does cooling lead to pyridoxal phosphate-aldimine bond cleavage in tryptophanase?
Biochimica et biophysica acta 2002;1594(2):335-40.
2002: Patrick Di Martino; Annabelle Merieau; Robert S Phillips; Nicole Orange; Christian Hulen
Isolation of an Escherichia coil strain mutant unable to form biofilm on polystyrene and to adhere to human pneumocyte cells: involvement of tryptophanase.
Canadian journal of microbiology 2002;48(2):132-7.
2001: E B Watkins; Robert S Phillips
Inhibition of tyrosine phenol-lyase from Citrobacter freundii by 2-azatyrosine and 3-azatyrosine.
Biochemistry 2001;40(49):14862-8.
2001: E B Watkins; Robert S Phillips
Enzymatic synthesis of aza-l-tyrosines.
Bioorganic & medicinal chemistry letters 2001;11(16):2099-100.
2001: C Heiss; Maris Laivenieks; J Gregory Zeikus; Robert S Phillips
Mutation of cysteine-295 to alanine in secondary alcohol dehydrogenase from Thermoanaerobacter ethanolicus affects the enantioselectivity and substrate specificity of ketone reductions.
Bioorganic & medicinal chemistry 2001;9(7):1659-66.
2001: C Heiss; Maris Laivenieks; J Gregory Zeikus; Robert S Phillips
The stereospecificity of secondary alcohol dehydrogenase from Thermoanaerobacter ethanolicus is partially determined by active site water.
Journal of the American Chemical Society 2001;123(2):345-6.
2000: Bakthavatsalam Sundararaju; H Chen; S Shilcutt; Robert S Phillips
The role of glutamic acid-69 in the activation of Citrobacter freundii tyrosine phenol-lyase by monovalent cations.
Biochemistry 2000;39(29):8546-55.
2000: J Xiong; Robert S Phillips; Donald M Kurtz; S Jin; Jingyuan Ai; Joann Sanders-Loehr
The O(2) binding pocket of myohemerythrin: role of a conserved leucine.
Biochemistry 2000;39(29):8526-36.
2000: C S Farmer; Donald M Kurtz; Robert S Phillips; Jingyuan Ai; Joann Sanders-Loehr
A leucine residue "Gates" solvent but not O2 access to the binding pocket of phascolopsis gouldii hemerythrin.
The Journal of biological chemistry 2000;275(22):17043-50.
2000: Maria V Barbolina; Robert S Phillips; Paul Gollnick; Nicolai G Faleev; Tatyana V Demidkina
Citrobacter freundii tyrosine phenol-lyase: the role of asparagine 185 in modulating enzyme function through stabilization of a quinonoid intermediate.
Protein engineering 2000;13(3):207-15.
1999: Graham R Moran; Robert S Phillips; Paul F Fitzpatrick
Influence of steric bulk and electrostatics on the hydroxylation regiospecificity of tryptophan hydroxylase: characterization of methyltryptophans and azatryptophans as substrates.
Biochemistry 1999;38(49):16283-9.
1999: L V Cyr; M G Newton; Robert S Phillips
Stereospecificity of Pseudomonas fluorescens kynureninase for diastereomers of beta-methylkynurenine.
Bioorganic & medicinal chemistry 1999;7(8):1497-503.
1999: M Welch; Robert S Phillips
Enzymatic syntheses of 6-(4H-selenolo[3,2-b]pyrrolyl)-L-alanine, 4-(6H-selenolo[2,3-b]pyrrolyl)-L-alanine, and 6-(4H-furo[3,2-b]pyrrolyl-L-alanine.
Bioorganic & medicinal chemistry letters 1999;9(5):637-40.
1998: Tali Erez; Robert S Phillips; Abraham H Parola
Pyridoxal phosphate binding to wild type, W330F, and C298S mutants of Escherichia coli apotryptophanase: unraveling the cold inactivation.
FEBS letters 1998;433(3):279-82.
1998: Robert S Phillips; K J Doshi
Cleavage of Escherichia coli tryptophan indole-lyase by trypsin at Lys406 affects the transmission of conformational changes associated with monovalent cation activation.
European journal of biochemistry / FEBS 1998;255(2):508-15.
1998: B Brooks; Robert S Phillips; W F Benisek
High-efficiency incorporation in vivo of tyrosine analogues with altered hydroxyl acidity in place of the catalytic tyrosine-14 of Delta 5-3-ketosteroid isomerase of Comamonas (Pseudomonas) testosteroni: effects of the modifications on isomerase kinetics.
Biochemistry 1998;37(27):9738-42.
1998: Robert S Phillips; Bakthavatsalam Sundararaju; SV Koushik
The catalytic mechanism of kynureninase from Pseudomonas fluorescens: evidence for transient quinonoid and ketimine intermediates from rapid-scanning stopped-flow spectrophotometry.
Biochemistry 1998;37(24):8783-9.
1998: Tali Erez; Y M Torchinsky; Robert S Phillips; Abraham H Parola
Cold inactivation and dissociation into dimers of Escherichia coli tryptophanase and its W330F mutant form.
Biochimica et biophysica acta 1998;1384(2):365-72.
1998: SV Koushik; J A Moore; Bakthavatsalam Sundararaju; Robert S Phillips
The catalytic mechanism of kynureninase from Pseudomonas fluorescens: insights from the effects of pH and isotopic substitution on steady-state and pre-steady-state kinetics.
Biochemistry 1998;37(5):1376-82.
1997: D S Burdette; F Secundo; Robert S Phillips; J Dong; Robert A Scott; J Gregory Zeikus
Biophysical and mutagenic analysis of Thermoanaerobacter ethanolicus secondary-alcohol dehydrogenase activity and specificity.
The Biochemical journal 1997;326 ( Pt 3)():717-24.
1997: SV Koushik; Bakthavatsalam Sundararaju; R A McGraw; Robert S Phillips
Cloning, sequence, and expression of kynureninase from Pseudomonas fluorescens.
Archives of biochemistry and biophysics 1997;344(2):301-8.
1997: Bakthavatsalam Sundararaju; Alfred A Antson; Robert S Phillips; Tatyana V Demidkina; Maria V Barbolina; Paul Gollnick; Guy G Dodson; K S Wilson
The crystal structure of Citrobacter freundii tyrosine phenol-lyase complexed with 3-(4'-hydroxyphenyl)propionic acid, together with site-directed mutagenesis and kinetic analysis, demonstrates that arginine 381 is required for substrate specificity.
Biochemistry 1997;36(21):6502-10.
1997: Robert S Phillips; R L Von Tersch; F Secundo
Effects of tyrosine ring fluorination on rates and equilibria of formation of intermediates in the reactions of carbon-carbon lyases.
European journal of biochemistry / FEBS 1997;244(2):658-63.
1996: M J Sloan; Robert S Phillips
Effects of alpha-deuteration and of aza and thia analogs of L-tryptophan on formation of intermediates in the reaction of Escherichia coli tryptophan indole-lyase.
Biochemistry 1996;35(50):16165-73.
1996: T Ben-Kasus; A Markel; Y M Torchinsky; Robert S Phillips; Abraham H Parola
Interactions of Escherichia coli tryptophanase with quasisubstrates and monovalent cations studied by the circular dichroism and fluorescence methods.
Biochimica et biophysica acta 1996;1294(2):147-52.
1996: N G Faleev; S N Spirina; V S Ivoilov; T V Demidkina; Robert S Phillips
The catalytic mechanism of tyrosine phenol-lyase from Erwinia herbicola: the effect of substrate structure on pH-dependence of kinetic parameters in the reactions with ring-substituted tyrosines.
Zeitschrift für Naturforschung. C, Journal of biosciences 1996;51(5-6):363-70.
1995: H Y Chen; T V Demidkina; Robert S Phillips
Site-directed mutagenesis of tyrosine-71 to phenylalanine in Citrobacter freundii tyrosine phenol-lyase: evidence for dual roles of tyrosine-71 as a general acid catalyst in the reaction mechanism and in cofactor binding.
Biochemistry 1995;34(38):12276-83.
1995: Philip A Cole; M R Grace; Robert S Phillips; P Burn; Christopher T Walsh
The role of the catalytic base in the protein tyrosine kinase Csk.
The Journal of biological chemistry 1995;270(38):22105-8.
1995: H Chen; P Gollnick; Robert S Phillips
Site-directed mutagenesis of His343-->Ala in Citrobacter freundii tyrosine phenol-lyase. Effects on the kinetic mechanism and rate-determining step.
European journal of biochemistry / FEBS 1995;229(2):540-9.
1995: M Lee; Robert S Phillips
The mechanism of Escherichia coli tryptophan indole-lyase: substituent effects on steady-state and pre-steady-state kinetic parameters for aryl-substituted tryptophan derivatives.
Bioorganic & medicinal chemistry 1995;3(2):195-205.
1993: H Chen; Robert S Phillips
Binding of phenol and analogues to alanine complexes of tyrosine phenol-lyase from Citrobacter freundii: implications for the mechanisms of alpha,beta-elimination and alanine racemization.
Biochemistry 1993;32(43):11591-9.
1993: Alfred A Antson; T V Demidkina; P Gollnick; Zbigniew Dauter; R L von Tersch; J Long; S N Berezhnoy; Robert S Phillips; EH Harutyunyan; Keith S Wilson
Three-dimensional structure of tyrosine phenol-lyase.
Biochemistry 1993;32(16):4195-206.
1992: Robert S Phillips; R K Dua
Indole protects tryptophan indole-lyase, but not tryptophan synthase, from inactivation by trifluoroalanine.
Archives of biochemistry and biophysics 1992;296(2):489-96.
1992: Masahiro Samejima; Robert S Phillips; K E Eriksson
Cellobiose oxidase from Phanerochaete chrysosporium. Stopped-flow spectrophotometric analysis of pH-dependent reduction.
FEBS letters 1992;306(2-3):165-8.
1992: S Ahmad; Robert S Phillips; C H Stammer
Inhibition of pig kidney L-aromatic amino acid decarboxylase by 2,3-methano-m-tyrosines.
Journal of medicinal chemistry 1992;35(8):1410-7.
1991: Robert S Phillips; I Richter; P Gollnick; Peter S Brzovic; Michael F Dunn
Replacement of lysine 269 by arginine in Escherichia coli tryptophan indole-lyase affects the formation and breakdown of quinonoid complexes.
The Journal of biological chemistry 1991;266(28):18642-8.
1991: Robert S Phillips
Reaction of indole and analogues with amino acid complexes of Escherichia coli tryptophan indole-lyase: detection of a new reaction intermediate by rapid-scanning stopped-flow spectrophotometry.
Biochemistry 1991;30(24):5927-34.
1990: Robert S Phillips; S L Bender; Peter S Brzovic; Michael F Dunn
Mechanism of binding of substrate analogues to tryptophan indole-lyase: studies using rapid-scanning and single-wavelength stopped-flow spectrophotometry.
Biochemistry 1990;29(37):8608-14.
1990: Robert S Phillips; P Gollnick
The environments of Trp-248 and Trp-330 in tryptophan indole-lyase from Escherichia coli.
FEBS letters 1990;268(1):213-6.
1990: Robert S Phillips; J G Fletcher; R L Von Tersch; K L Kirk
Oxygenation of fluorinated tyrosines by mushroom tyrosinase releases fluoride ion.
Archives of biochemistry and biophysics 1990;276(1):65-9.
1989: Robert S Phillips; P D Gollnick
Evidence that cysteine 298 is in the active site of tryptophan indole-lyase.
The Journal of biological chemistry 1989;264(18):10627-32.
1988: M Roy; Edith Wilson Miles; Robert S Phillips; Michael F Dunn
Detection and identification of transient intermediates in the reactions of tryptophan synthase with oxindolyl-L-alanine and 2,3-dihydro-L-tryptophan. Evidence for a tetrahedral (gem-diamine) intermediate.
Biochemistry 1988;27(23):8661-9.
1988: D M Kiick; Robert S Phillips
Mechanistic deductions from kinetic isotope effects and pH studies of pyridoxal phosphate dependent carbon-carbon lyases: Erwinia herbicola and Citrobacter freundii tyrosine phenol-lyase.
Biochemistry 1988;27(19):7333-8.
1988: D M Kiick; Robert S Phillips
Mechanistic deductions from multiple kinetic and solvent deuterium isotope effects and pH studies of pyridoxal phosphate dependent carbon-carbon lyases: Escherichia coli tryptophan indole-lyase.
Biochemistry 1988;27(19):7339-44.
1988: Robert S Phillips; R Q Marmorstein
6-Nitro-L-tryptophan: a novel spectroscopic probe of trp aporepressor and human serum albumin.
Archives of biochemistry and biophysics 1988;262(1):337-44.
1987: Robert S Phillips
Reactions of O-acyl-L-serines with tryptophanase, tyrosine phenol-lyase, and tryptophan synthase.
Archives of biochemistry and biophysics 1987;256(1):302-10.
1986: E W Miles; Robert S Phillips; H J Yeh; L A Cohen
Isomerization of (3S)-2,3-dihydro-5-fluoro-L-tryptophan and of 5-fluoro-L-tryptophan catalyzed by tryptophan synthase: studies using fluorine-19 nuclear magnetic resonance and difference spectroscopy.
Biochemistry 1986;25(15):4240-9.
1986: M Iwaki; Robert S Phillips; S Kaufman
Proteolytic modification of the amino-terminal and carboxyl-terminal regions of rat hepatic phenylalanine hydroxylase.
The Journal of biological chemistry 1986;261(5):2051-6.
1985: Robert S Phillips; E W Miles; L A Cohen
Differential inhibition of tryptophan synthase and of tryptophanase by the two diastereoisomers of 2,3-dihydro-L-tryptophan. Implications for the stereochemistry of the reaction intermediates.
The Journal of biological chemistry 1985;260(27):14665-70.
1985: E W Miles; Robert S Phillips
Photoinactivation and photoaffinity labeling of tryptophan synthase alpha 2 beta 2 complex by the product analogue 6-azido-L-tryptophan.
Biochemistry 1985;24(17):4694-703.
1984: Robert S Phillips; E W Miles; L A Cohen
Interactions of tryptophan synthase, tryptophanase, and pyridoxal phosphate with oxindolyl-L-alanine and 2,3-dihydro-L-tryptophan: support for an indolenine intermediate in tryptophan metabolism.
Biochemistry 1984;23(25):6228-34.
1984: Robert S Phillips; M A Parniak; S Kaufman
Spectroscopic investigation of ligand interaction with hepatic phenylalanine hydroxylase: evidence for a conformational change associated with activation.
Biochemistry 1984;23(17):3836-42.
1984: Robert S Phillips; S Kaufman
Ligand effects on the phosphorylation state of hepatic phenylalanine hydroxylase.
The Journal of biological chemistry 1984;259(4):2474-9.
1984: Robert S Phillips; M A Parniak; S Kaufman
The interaction of aromatic amino acids with rat liver phenylalanine hydroxylase.
The Journal of biological chemistry 1984;259(1):271-7.
1983: Robert S Phillips; M Iwaki; S Kaufman
Ligand effects on the limited proteolysis of phenylalanine hydroxylase: evidence for multiple conformational states.
Biochemical and biophysical research communications 1983;110(3):919-25.
1983: Sheldon W May; P W Mueller; S R Padgette; H H Herman; Robert S Phillips
Dopamine-B-hydroxylase: suicide inhibition by the novel olefinic substrate, 1-phenyl-1-aminomethylethene.
Biochemical and biophysical research communications 1983;110(1):161-8.
1983: Robert S Phillips; S Kaufman
On the nature of the spontaneous activation of hepatic phenylalanine hydroxylase.
Transactions of the New York Academy of Sciences 1983;41():87-95.
1982: Sheldon W May; Robert S Phillips; H H Herman; P W Mueller
Bioactivation of Catha edulis alkaloids: enzymatic ketonization of norpseudoephedrine.
Biochemical and biophysical research communications 1982;104(1):38-44.
1981: Sheldon W May; Robert S Phillips; P W Mueller; H H Herman
Dopamine beta-hydroxylase. Comparative specificities and mechanisms of the oxygenation reactions.
The Journal of biological chemistry 1981;256(16):8470-5.
1981: Sheldon W May; Robert S Phillips; P W Mueller; H H Herman
Dopamine beta-hydroxylase. Demonstration of enzymatic ketonization of the product enantiomer S-octopamine.
The Journal of biological chemistry 1981;256(5):2258-61.
1979: Sheldon W May; Robert S Phillips
Protocatechuate 3,4-dioxygenase: implications of ionization effects on binding and dissociation of halohydroxybenzoates and on catalytic turnover.
Biochemistry 1979;18(26):5933-9.
1978: R H Felton; L D Cheung; Robert S Phillips; Sheldon W May
A resonance Raman study of substrate and inhibitor binding to protocatechuate-3,4-dioxygenase.
Biochemical and biophysical research communications 1978;85(2):844-50.
1978: Sheldon W May; Robert S Phillips; C D Oldham
Interaction of protocatechuate-3,4-dioxygenase with fluoro-substituted hydroxybenzoic acids and related compounds.
Biochemistry 1978;17(10):1853-60.