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Pietro Pichierri

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I Murfuni; S Nicolai; S Baldari; Margherita Bignami; M Crescenzi; Antonio Franchitto; Pietro Pichierri
The WRN and MUS81 proteins limit cell death and genome instability following oncogene activation.
Pietro Pichierri; S Nicolai; Margherita Bignami; L Cignolo; Antonio Franchitto
The RAD9-RAD1-HUS1 (9.1.1) complex interacts with WRN and is crucial to regulate its response to replication fork stalling.
Pietro Pichierri; Francesca Ammazzalorso; Margherita Bignami; Antonio Franchitto
The Werner syndrome protein: linking the replication checkpoint response to genome stability.

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All Publications

2013: I Murfuni; S Nicolai; S Baldari; Margherita Bignami; M Crescenzi; Antonio Franchitto; Pietro Pichierri
The WRN and MUS81 proteins limit cell death and genome instability following oncogene activation.
Oncogene 2013;32(5):610-20.
2012: Pietro Pichierri; S Nicolai; Margherita Bignami; L Cignolo; Antonio Franchitto
The RAD9-RAD1-HUS1 (9.1.1) complex interacts with WRN and is crucial to regulate its response to replication fork stalling.
Oncogene 2012;31(23):2809-23.
2011: Pietro Pichierri; Francesca Ammazzalorso; Margherita Bignami; Antonio Franchitto
The Werner syndrome protein: linking the replication checkpoint response to genome stability.
Aging 2011;3(3):311-8.
2010: Francesca Ammazzalorso; Livia Maria Pirzio; Margherita Bignami; Antonio Franchitto; Pietro Pichierri
ATR and ATM differently regulate WRN to prevent DSBs at stalled replication forks and promote replication fork recovery.
The EMBO journal 2010;29(18):3156-69.
2008: Antonio Franchitto; Livia Maria Pirzio; Ennio Prosperi; Orazio Sapora; Margherita Bignami; Pietro Pichierri
Replication fork stalling in WRN-deficient cells is overcome by prompt activation of a MUS81-dependent pathway.
The Journal of cell biology 2008;183(2):241-52.
2008: Livia Maria Pirzio; Pietro Pichierri; Margherita Bignami; Antonio Franchitto
Werner syndrome helicase activity is essential in maintaining fragile site stability.
The Journal of cell biology 2008;180(2):305-14.
2007: Pietro Pichierri
Interplay between wrn and the checkpoint in s-phase.
The Italian journal of biochemistry 2007;56(2):130-40.
2006: Monica Savio; Michaela Cerri; Ornella Cazzalini; Paola Perucca; Lucia A Stivala; Pietro Pichierri; Antonio Franchitto; Laurent Meijer; Ennio Prosperi
Replication-dependent DNA damage response triggered by roscovitine induces an uncoupling of DNA replication proteins.
Cell cycle (Georgetown, Tex.) 2006;5(18):2153-9.
2004: Antonio Franchitto; Pietro Pichierri
Werner syndrome protein and the MRE11 complex are involved in a common pathway of replication fork recovery.
Cell cycle (Georgetown, Tex.) 2004;3(10):1331-9.
2004: Pietro Pichierri; Antonio Franchitto; Filippo Rosselli
BLM and the FANC proteins collaborate in a common pathway in response to stalled replication forks.
The EMBO journal 2004;23(15):3154-63.
2004: Pietro Pichierri; Filippo Rosselli
Fanconi anemia proteins and the s phase checkpoint.
Cell cycle (Georgetown, Tex.) 2004;3(6):698-700.
2004: Pietro Pichierri; Filippo Rosselli
The DNA crosslink-induced S-phase checkpoint depends on ATR-CHK1 and ATR-NBS1-FANCD2 pathways.
The EMBO journal 2004;23(5):1178-87.
2004: Pietro Pichierri; Antonio Franchitto
Werner syndrome protein, the MRE11 complex and ATR: menage-à-trois in guarding genome stability during DNA replication?
BioEssays : news and reviews in molecular, cellular and developmental biology 2004;26(3):306-13.
2003: Filippo Rosselli; Delphine Briot; Pietro Pichierri
The Fanconi anemia pathway and the DNA interstrand cross-links repair.
Biochimie 2003;85(11):1175-84.
2003: Antonio Franchitto; Oshima Junko; Pietro Pichierri
The G2-phase decatenation checkpoint is defective in Werner syndrome cells.
Cancer research 2003;63(12):3289-95.
2003: Antonio Franchitto; Pietro Pichierri; Rita Piergentili; Marco Crescenzi; Margherita Bignami; Fabrizio Palitti
The mammalian mismatch repair protein MSH2 is required for correct MRE11 and RAD51 relocalization and for efficient cell cycle arrest induced by ionizing radiation in G2 phase.
Oncogene 2003;22(14):2110-20.
2003: Pietro Pichierri; Filippo Rosselli; Antonio Franchitto
Werner's syndrome protein is phosphorylated in an ATR/ATM-dependent manner following replication arrest and DNA damage induced during the S phase of the cell cycle.
Oncogene 2003;22(10):1491-500.
2002: Pietro Pichierri; Dietrich Averbeck; Filippo Rosselli
DNA cross-link-dependent RAD50/MRE11/NBS1 subnuclear assembly requires the Fanconi anemia C protein.
Human molecular genetics 2002;11(21):2531-46.
2002: Antonio Franchitto; Pietro Pichierri
Protecting genomic integrity during DNA replication: correlation between Werner's and Bloom's syndrome gene products and the MRE11 complex.
Human molecular genetics 2002;11(20):2447-53.
2002: Antonio Franchitto; Pietro Pichierri
Bloom's syndrome protein is required for correct relocalization of RAD50/MRE11/NBS1 complex after replication fork arrest.
The Journal of cell biology 2002;157(1):19-30.
2002: Luca Proietti de Santis; Claudia Lorenti Garcia; Adayabalam S Balajee; Paolo Latini; Pietro Pichierri; Osamu Nikaido; Miria Stefanini; Fabrizio Palitti
Transcription coupled repair efficiency determines the cell cycle progression and apoptosis after UV exposure in hamster cells.
DNA repair 2002;1(3):209-23.
2001: Pietro Pichierri; Antonio Franchitto; R Piergentili; C Colussi; Fabrizio Palitti
Hypersensitivity to camptothecin in MSH2 deficient cells is correlated with a role for MSH2 protein in recombinational repair.
Carcinogenesis 2001;22(11):1781-7.
2001: Pietro Pichierri; Antonio Franchitto; Pasquale Mosesso; Fabrizio Palitti
Werner's syndrome protein is required for correct recovery after replication arrest and DNA damage induced in S-phase of cell cycle.
Molecular biology of the cell 2001;12(8):2412-21.
2001: Antonio Franchitto; Pietro Pichierri; M Genuardi; A De Santis; Fabrizio Palitti
Investigation of G2-phase chromosomal radiosensitivity in hereditary non-polyposis colorectal cancer cells.
International journal of radiation biology 2001;77(7):773-80.
2000: Pietro Pichierri; Antonio Franchitto; Pasquale Mosesso; Fabrizio Palitti
Werner's syndrome cell lines are hypersensitive to camptothecin-induced chromosomal damage.
Mutation research 2000;456(1-2):45-57.
2000: Pasquale Mosesso; Pietro Pichierri; Antonio Franchitto; Fabrizio Palitti
Evidence that camptothecin-induced aberrations in the G(2) phase of cell cycle of Chinese hamster ovary (CHO) cell lines is associated with transcription.
Mutation research 2000;452(2):189-95.
2000: Antonio Franchitto; Pietro Pichierri; Pasquale Mosesso; Fabrizio Palitti
Catalytic inhibition of topoisomerase II in Werner's syndrome cell lines enhances chromosomal damage induced by X-rays in the G2 phase of the cell cycle.
International journal of radiation biology 2000;76(7):913-22.
2000: Pietro Pichierri; Antonio Franchitto; Pasquale Mosesso; Luca Proietti de Santis; Adayabalam S Balajee; Fabrizio Palitti
Werner's syndrome lymphoblastoid cells are hypersensitive to topoisomerase II inhibitors in the G2 phase of the cell cycle.
Mutation research 2000;459(2):123-33.
1999: Antonio Franchitto; Luca Proietti de Santis; Pietro Pichierri; Pasquale Mosesso; Fabrizio Palitti
Lack of effect of caffeine post-treatment on X-ray-induced chromosomal aberrations in Werner's syndrome lymphoblastoid cell lines: a preliminary report.
International journal of radiation biology 1999;75(11):1349-55.
1999: Fabrizio Palitti; Pietro Pichierri; Antonio Franchitto; Luca Proietti de Santis; Pasquale Mosesso
Chromosome radiosensitivity in human G2 lymphocytes and cell-cycle progression.
International journal of radiation biology 1999;75(5):621-7.
1998: Antonio Franchitto; Pietro Pichierri; Pasquale Mosesso; Fabrizio Palitti
Caffeine effect on the mitotic delay induced by G2 treatment with UVC or mitomycin C.
Mutagenesis 1998;13(5):499-505.