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Werner Pichler

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Natascha Wuillemin; Jacqueline Adam; Stefano Fontana; Stephan Krähenbühl; Werner J Pichler; Daniel Yerly
HLA Haplotype Determines Hapten or p-i T Cell Reactivity to Flucloxacillin.
P Jandus; Werner J Pichler; O Hausmann; Arthur Helbling
Intravenous immunoglobulin in urticaria.
Benno Schnyder; Werner J Pichler
Allergy to sulfonamides.

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All Publications

2013: Natascha Wuillemin; Jacqueline Adam; Stefano Fontana; Stephan Krähenbühl; Werner J Pichler; Daniel Yerly
HLA Haplotype Determines Hapten or p-i T Cell Reactivity to Flucloxacillin.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(10):4956-64.
2013: P Jandus; Werner J Pichler; O Hausmann; Arthur Helbling
Intravenous immunoglobulin in urticaria.
Journal of investigational allergology & clinical immunology : official organ of the International Association of Asthmology (INTERASMA) and Sociedad Latinoamericana de Alergia e Inmunología 2013;23(1):71-3.
2013: Benno Schnyder; Werner J Pichler
Allergy to sulfonamides.
The Journal of allergy and clinical immunology 2013;131(1):256-7.e1-5.
2012: J Yun; D Yerly; J Adam; Werner J Pichler
Human leukocyte antigens (HLA) associated drug hypersensitivity: consequences of drug binding to HLA.
Allergy 2012;67(11):1338-46.
2012: Jacqueline Adam; Klara K Eriksson; Stefano Fontana; Werner J Pichler; Benno Schnyder; Daniel Yerly
Avidity determines T-cell reactivity in abacavir hypersensitivity.
European journal of immunology 2012;42(7):1706-16.
2012: Benno Schnyder; Werner J Pichler
Nonimmediate drug allergy: diagnostic benefit of skin testing and practical approach.
The Journal of allergy and clinical immunology 2012;129(4):1170-1.
2011: Thomas Gentinetta; Clemens A Dahinden; Franco H Falcone; Tatjana Pecaric-Petkovic; Werner J Pichler; Daniel Wan; Oliver V Hausmann
Individual IL-3 priming is crucial for consistent in vitro activation of donor basophils in patients with chronic urticaria.
The Journal of allergy and clinical immunology 2011;128(6):1227-1234.e5.
2011: Ayman Elsheikh; Luis Castrejon; Sidonie N Lavergne; Paul Whitaker; Manal Monshi; Hayley Callan; Sabah El-Ghaiesh; John Farrell; Werner J Pichler; Daniel Peckham; B Kevin Park; Dean J Naisbitt
Enhanced antigenicity leads to altered immunogenicity in sulfamethoxazole-hypersensitive patients with cystic fibrosis.
The Journal of allergy and clinical immunology 2011;127(6):1543-51.e3.
2011: Jacqueline Adam; Werner J Pichler; Daniel Yerly
Delayed drug hypersensitivity: models of T-cell stimulation.
British journal of clinical pharmacology 2011;71(5):701-7.
2011: G Porebski; A Gschwend-Zawodniak; Werner J Pichler
In vitro diagnosis of T cell-mediated drug allergy.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2011;41(4):461-70.
2011: Werner J Pichler; Dean J Naisbitt; B Kevin Park
Immune pathomechanism of drug hypersensitivity reactions.
The Journal of allergy and clinical immunology 2011;127(3 Suppl):S74-81.
2011: O V Hausmann; T Gentinetta; Michaela Fux; S Ducrest; Werner J Pichler; Clemens Dahinden
Robust expression of CCR3 as a single basophil selection marker in flow cytometry.
Allergy 2011;66(1):85-91.
2010: Ayman Elsheikh; Sidonie N Lavergne; J Luis Castrejon; John Farrell; Haiyi Wang; Jean Sathish; Werner J Pichler; B Kevin Park; Dean J Naisbitt
Drug antigenicity, immunogenicity, and costimulatory signaling: evidence for formation of a functional antigen through immune cell metabolism.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(11):6448-60.
2010: Werner J Pichler; Jaqueline Adam; Barbara Daubner; Thomas Gentinetta; Monika Keller; Daniel Yerly
Drug hypersensitivity reactions: pathomechanism and clinical symptoms.
The Medical clinics of North America 2010;94(4):645-64, xv.
2010: Werner J Pichler
The area of drug hypersensitivity has been widely neglected not least because it is a complex area. Preface.
The Medical clinics of North America 2010;94(4):xv-vi.
2010: A Zawodniak; P Lochmatter; D Yerly; T Kawabata; Marianne Lerch; Nikhil Yawalkar; Werner J Pichler
In vitro detection of cytotoxic T and NK cells in peripheral blood of patients with various drug-induced skin diseases.
Allergy 2010;65(3):376-84.
2010: J Luis Castrejon; Neil Berry; Sabah El-Ghaiesh; Basil Gerber; Werner J Pichler; B Kevin Park; Dean J Naisbitt
Stimulation of human T cells with sulfonamides and sulfonamide metabolites.
The Journal of allergy and clinical immunology 2010;125(2):411-418.e4.
2010: Oliver Hausmann; Benno Schnyder; Werner J Pichler
Drug hypersensitivity reactions involving skin.
Handbook of experimental pharmacology 2010;(196):29-55.
2009: P Lochmatter; A Beeler; T T Kawabata; B O Gerber; Werner J Pichler
Drug-specific in vitro release of IL-2, IL-5, IL-13 and IFN-gamma in patients with delayed-type drug hypersensitivity.
Allergy 2009;64(9):1269-78.
2009: Stéphane Cook; Elena Ladich; Gaku Nakazawa; Parham Eshtehardi; Michel Neidhart; Rolf Vogel; Mario Togni; Peter M Wenaweser; Michael Billinger; Christian Seiler; Steffen Gay; Bernhard Meier; Werner J Pichler; Peter Jüni; Renu Virmani; Stephan Windecker
Correlation of intravascular ultrasound findings with histopathological analysis of thrombus aspirates in patients with very late drug-eluting stent thrombosis.
Circulation 2009;120(5):391-9.
2009: Priska Lochmatter; Anna Zawodniak; Werner J Pichler
In vitro tests in drug hypersensitivity diagnosis.
Immunology and allergy clinics of North America 2009;29(3):537-54.
2009: Benno Schnyder; Werner J Pichler
Mechanisms of drug-induced allergy.
Mayo Clinic proceedings. Mayo Clinic 2009;84(3):268-72.
2008: Daniel Yerly; David Heckerman; Todd Allen; Todd J Suscovich; Nebojsa Jojic; Carl Kadie; Werner J Pichler; Andreas Cerny; Christian Brander
Design, expression, and processing of epitomized hepatitis C virus-encoded CTL epitopes.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(9):6361-70.
2008: Andreas Beeler; L Zaccaria; T Kawabata; Basil O Gerber; Werner J Pichler
CD69 upregulation on T cells as an in vitro marker for delayed-type drug hypersensitivity.
Allergy 2008;63(2):181-8.
2007: Marianne Lerch; Monika Keller; Markus Britschgi; Gisele Kanny; Valerie Tache; Daphne A Schmid; Andreas Beeler; Basil O Gerber; Michael Luethi; Andreas J Bircher; Cathrine Christiansen; Werner J Pichler
Cross-reactivity patterns of T cells specific for iodinated contrast media.
The Journal of allergy and clinical immunology 2007;119(6):1529-36.
2006: Andreas Beeler; Werner J Pichler
In vitro tests of T cell-mediated drug hypersensitivity.
Expert review of clinical immunology 2006;2(6):887-900.
2006: Zoi Spanou; Monika Keller; Markus Britschgi; Nikhil Yawalkar; Thomas Fehr; Jörg Neuweiler; Mathias Gugger; Markus G Mohaupt; Werner J Pichler
Involvement of drug-specific T cells in acute drug-induced interstitial nephritis.
Journal of the American Society of Nephrology : JASN 2006;17(10):2919-27.
2006: Ying Wu; Joseph Sanderson; John Farrell; Nicola S Drummond; Anita Hanson; Elizabeth Bowkett; Neil Berry; Andrew V Stachulski; Stephen E Clarke; Werner J Pichler; Munir Pirmohamed; B Kevin Park; Dean J Naisbitt
Activation of T cells by carbamazepine and carbamazepine metabolites.
The Journal of allergy and clinical immunology 2006;118(1):233-41.
2006: Daphné Anne Schmid; Jan P H Depta; Michael Lüthi; Werner J Pichler
Transfection of drug-specific T-cell receptors into hybridoma cells: tools to monitor drug interaction with T-cell receptors and evaluate cross-reactivity to related compounds.
Molecular pharmacology 2006;70(1):356-65.
2006: Werner J Pichler; Andreas Beeler; Monika Keller; Marianne Lerch; Sinforiano Posadas; Daphné Schmid; Zoi Spanou; Anna Zawodniak; Basil Gerber
Pharmacological interaction of drugs with immune receptors: the p-i concept.
Allergology international : official journal of the Japanese Society of Allergology 2006;55(1):17-25.
2006: Andreas Beeler; Olivier B Engler; Basil O Gerber; Werner J Pichler
Long-lasting reactivity and high frequency of drug-specific T cells after severe systemic drug hypersensitivity reactions.
The Journal of allergy and clinical immunology 2006;117(2):455-62.
2006: Daphné Anne Schmid; Paolo Campi; Werner J Pichler
Hypersensitivity reactions to quinolones.
Current pharmaceutical design 2006;12(26):3313-26.
2006: C Gex-Collet; L Imhof; A Brattström; Werner J Pichler; Arthur Helbling
The butterbur extract petasin has no effect on skin test reactivity induced by different stimuli: a randomized, double-blind crossover study using histamine, codeine, methacholine, and aeroallergen solutions.
Journal of investigational allergology & clinical immunology : official organ of the International Association of Asthmology (INTERASMA) and Sociedad Latinoamericana de Alergia e Inmunología 2006;16(3):156-61.
2006: Basil O Gerber; Werner J Pichler
Noncovalent interactions of drugs with immune receptors may mediate drug-induced hypersensitivity reactions.
The AAPS journal 2006;8(1):E160-5.
2006: Daphné Anne Schmid; Jan P H Depta; Werner J Pichler
T cell-mediated hypersensitivity to quinolones: mechanisms and cross-reactivity.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2006;36(1):59-69.
2005: Monika Keller; Zoi Spanou; Patrick Schaerli; Markus Britschgi; Nikhil Yawalkar; Michael Seitz; Peter M Villiger; Werner J Pichler
T cell-regulated neutrophilic inflammation in autoinflammatory diseases.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(11):7678-86.
2005: Werner J Pichler
Direct T-cell stimulations by drugs--bypassing the innate immune system.
Toxicology 2005;209(2):95-100.
2005: C Gex-Collet; Arthur Helbling; Werner J Pichler
Multiple drug hypersensitivity--proof of multiple drug hypersensitivity by patch and lymphocyte transformation tests.
Journal of investigational allergology & clinical immunology : official organ of the International Association of Asthmology (INTERASMA) and Sociedad Latinoamericana de Alergia e Inmunología 2005;15(4):293-6.
2004: Basil O Gerber; Werner J Pichler
Cellular mechanisms of T cell mediated drug hypersensitivity.
Current opinion in immunology 2004;16(6):732-7.
2004: X Bucher; Werner J Pichler; Clemens Dahinden; Arthur Helbling
Effect of tree pollen specific, subcutaneous immunotherapy on the oral allergy syndrome to apple and hazelnut.
Allergy 2004;59(12):1272-6.
2004: Olivier B Engler; Reto Schwendener; Wen Juan Dai; Benno Wölk; Werner J Pichler; Darius Moradpour; Thomas Brunner; Andreas Cerny
A liposomal peptide vaccine inducing CD8+ T cells in HLA-A2.1 transgenic mice, which recognise human cells encoding hepatitis C virus (HCV) proteins.
Vaccine 2004;23(1):58-68.
2004: Marianne Lerch; Werner J Pichler
The immunological and clinical spectrum of delayed drug-induced exanthems.
Current opinion in allergy and clinical immunology 2004;4(5):411-9.
2004: Patrick Schaerli; Markus Britschgi; Monika Keller; Urs C Steiner; Lisa S Steinmann; Bernhard Moser; Werner J Pichler
Characterization of human T cells that regulate neutrophilic skin inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(3):2151-8.
2004: Werner J Pichler
Immune mechanism of drug hypersensitivity.
Immunology and allergy clinics of North America 2004;24(3):373-97, v-vi.
2004: Werner J Pichler; J Tilch
The lymphocyte transformation test in the diagnosis of drug hypersensitivity.
Allergy 2004;59(8):809-20.
2004: Petra C Kuechler; Markus Britschgi; Simone Schmid; Y Hari; Benno Grabscheid; Werner J Pichler
Cytotoxic mechanisms in different forms of T-cell-mediated drug allergies.
Allergy 2004;59(6):613-22.
2004: Olivier B Engler; Ingrid Strasser; Dean J Naisbitt; Andreas Cerny; Werner J Pichler
A chemically inert drug can stimulate T cells in vitro by their T cell receptor in non-sensitised individuals.
Toxicology 2004;197(1):47-56.
2004: Jan P H Depta; Frank Altznauer; Katharina Gamerdinger; Christoph Burkhart; Hans Ulrich Weltzien; Werner J Pichler
Drug interaction with T-cell receptors: T-cell receptor density determines degree of cross-reactivity.
The Journal of allergy and clinical immunology 2004;113(3):519-27.
2004: L M Herwig; Arthur Helbling; Werner J Pichler; Christiane Pichler
[Allergy to house dust mites: allergy independent symptoms dominate].
Praxis 2004;93(8):267-73.
2004: Arthur Helbling; T Hurni; U R Mueller; Werner J Pichler
Incidence of anaphylaxis with circulatory symptoms: a study over a 3-year period comprising 940,000 inhabitants of the Swiss Canton Bern.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2004;34(2):285-90.
2004: Christel Gremion; Benno Grabscheid; Benno Wölk; Darius Moradpour; Jürg Reichen; Werner J Pichler; Andreas Cerny
Cytotoxic T lymphocytes derived from patients with chronic hepatitis C virus infection kill bystander cells via Fas-FasL interaction.
Journal of virology 2004;78(4):2152-7.
2003: Werner J Pichler
Delayed drug hypersensitivity reactions.
Annals of internal medicine 2003;139(8):683-93.
2003: Jan P H Depta; Werner J Pichler
Cross-reactivity with drugs at the T cell level.
Current opinion in allergy and clinical immunology 2003;3(4):261-7.
2003: Werner J Pichler
Drug-induced autoimmunity.
Current opinion in allergy and clinical immunology 2003;3(4):249-53.
2003: Dean J Naisbitt; John Farrell; Gavin Wong; Jan P H Depta; Charlotte C Dodd; Josephine E Hopkins; Claire A Gibney; David W Chadwick; Werner J Pichler; Munir Pirmohamed; B Kevin Park
Characterization of drug-specific T cells in lamotrigine hypersensitivity.
The Journal of allergy and clinical immunology 2003;111(6):1393-403.
2003: Dean J Naisbitt; Markus Britschgi; G Wong; John Farrell; Jan P H Depta; David W Chadwick; Werner J Pichler; Munir Pirmohamed; B Kevin Park
Hypersensitivity reactions to carbamazepine: characterization of the specificity, phenotype, and cytokine profile of drug-specific T cell clones.
Molecular pharmacology 2003;63(3):732-41.
2003: K Hug; Nikhil Yawalkar; Arthur Helbling; Werner J Pichler
Scratch-patch and patch testing in drug allergy--an assessment of specificity.
Journal of investigational allergology & clinical immunology : official organ of the International Association of Asthmology (INTERASMA) and Sociedad Latinoamericana de Alergia e Inmunología 2003;13(1):12-9.
2003: Werner J Pichler
Lessons from drug allergy: against dogmata.
Current allergy and asthma reports 2003;3(1):1-3.
2003: Markus Britschgi; Salome von Greyerz; Christoph Burkhart; Werner J Pichler
Molecular aspects of drug recognition by specific T cells.
Current drug targets 2003;4(1):1-11.
2002: Werner J Pichler
Modes of presentation of chemical neoantigens to the immune system.
Toxicology 2002;181-182():49-54.
2002: Andrea Reimers; Christiane Pichler; Arthur Helbling; Werner J Pichler; Nikhil Yawalkar
Zafirlukast has no beneficial effects in the treatment of chronic urticaria.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2002;32(12):1763-8.
2002: Simone Schmid; Petra C Kuechler; Markus Britschgi; Urs C Steiner; Nikhil Yawalkar; Alain Limat; Kurt Baltensperger; Lasse R Braathen; Werner J Pichler
Acute generalized exanthematous pustulosis: role of cytotoxic T cells in pustule formation.
The American journal of pathology 2002;161(6):2079-86.
2002: Christoph Burkhart; Markus Britschgi; Ingrid Strasser; Jan P H Depta; Salome von Greyerz; V Barnaba; Werner J Pichler
Non-covalent presentation of sulfamethoxazole to human CD4+ T cells is independent of distinct human leucocyte antigen-bound peptides.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2002;32(11):1635-43.
2002: Werner J Pichler; Nikhil Yawalkar; Simone Schmid; Arthur Helbling
Pathogenesis of drug-induced exanthems.
Allergy 2002;57(10):884-93.
2002: Barbara Lotti; Thomas Wendland; Hansjakob Furrer; Nikhil Yawalkar; Salome von Greyerz; Karin Schnyder; Marlene Brandes; Pietro Vernazza; Ralf Wagner; Thi Nguyen; Eric Rosenberg; Werner J Pichler; Christian Brander
Cytotoxic HIV-1 p55gag-specific CD4+ T cells produce HIV-inhibitory cytokines and chemokines.
Journal of clinical immunology 2002;22(5):253-62.
2002: Dean J Naisbitt; John Farrell; S Fraser Gordon; James L Maggs; Christoph Burkhart; Werner J Pichler; Munir Pirmohamed; B Kevin Park
Covalent binding of the nitroso metabolite of sulfamethoxazole leads to toxicity and major histocompatibility complex-restricted antigen presentation.
Molecular pharmacology 2002;62(3):628-37.
2002: Markus Britschgi; Werner J Pichler
Acute generalized exanthematous pustulosis, a clue to neutrophil-mediated inflammatory processes orchestrated by T cells.
Current opinion in allergy and clinical immunology 2002;2(4):325-31.
2002: Werner J Pichler
Pharmacological interaction of drugs with antigen-specific immune receptors: the p-i concept.
Current opinion in allergy and clinical immunology 2002;2(4):301-5.
2002: Isabelle P Hunziker; Benno Grabscheid; Rinaldo Zurbriggen; Reinhard Glück; Werner J Pichler; Andreas Cerny
In vitro studies of core peptide-bearing immunopotentiating reconstituted influenza virosomes as a non-live prototype vaccine against hepatitis C virus.
International immunology 2002;14(6):615-26.
2002: Arthur Helbling; N Bonadies; Karl A Brander; Werner J Pichler
Boletus edulis: a digestion-resistant allergen may be relevant for food allergy.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2002;32(5):771-5.
2002: M Degonda; Werner J Pichler; A Bircher; Arthur Helbling
[Chronic idiopathic urticaria: effectiveness of fexofenadine. A double-blind, placebo controlled study with 21 patients].
Praxis 2002;91(15):637-43.
2002: Werner J Pichler
Deciphering the immune pathomechanism of cutaneous drug reactions.
Allergy 2002;57 Suppl 72():34-6.
2002: Werner J Pichler; Nikhil Yawalkar; Markus Britschgi; Jan P H Depta; Ingrid Strasser; Simone Schmid; Petra C Kuechler; Dean J Naisbitt
Cellular and molecular pathophysiology of cutaneous drug reactions.
American journal of clinical dermatology 2002;3(4):229-38.
2002: Werner J Pichler
T cells in drug allergy.
Current allergy and asthma reports 2002;2(1):9-15.
2001: Isabelle P Hunziker; Rinaldo Zurbriggen; R Glueck; Olivier B Engler; Jürg Reichen; Wen Juan Dai; Werner J Pichler; Andreas Cerny
Perspectives: towards a peptide-based vaccine against hepatitis C virus.
Molecular immunology 2001;38(6):475-84.
2001: Olivier B Engler; Wen Juan Dai; A Sette; Isabelle P Hunziker; Jürg Reichen; Werner J Pichler; Andreas Cerny
Peptide vaccines against hepatitis B virus: from animal model to human studies.
Molecular immunology 2001;38(6):457-65.
2001: Y Hari; K Frutig-Schnyder; M Hurni; Nikhil Yawalkar; MP Zanni; B Schnyder; A Kappeler; Salome von Greyerz; Lasse R Braathen; Werner J Pichler
T cell involvement in cutaneous drug eruptions.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2001;31(9):1398-408.
2001: Salome von Greyerz; G Bültemann; K Schnyder; Christoph Burkhart; B Lotti; Y Hari; Werner J Pichler
Degeneracy and additional alloreactivity of drug-specific human alpha beta(+) T cell clones.
International immunology 2001;13(7):877-85.
2001: Markus Britschgi; Urs C Steiner; Simone Schmid; Jan P H Depta; Gabriela Senti; Andreas J Bircher; Christoph Burkhart; Nikhil Yawalkar; Werner J Pichler
T-cell involvement in drug-induced acute generalized exanthematous pustulosis.
The Journal of clinical investigation 2001;107(11):1433-41.
2001: Dean J Naisbitt; S Fraser Gordon; Munir Pirmohamed; Christoph Burkhart; A E Cribb; Werner J Pichler; B Kevin Park
Antigenicity and immunogenicity of sulphamethoxazole: demonstration of metabolism-dependent haptenation and T-cell proliferation in vivo.
British journal of pharmacology 2001;133(2):295-305.
2001: Christiane Pichler; Arthur Helbling; Werner J Pichler
Three years of specific immunotherapy with house-dust-mite extracts in patients with rhinitis and asthma: significant improvement of allergen-specific parameters and of nonspecific bronchial hyperreactivity.
Allergy 2001;56(4):301-6.
2001: Nikhil Yawalkar; Robert E Hunger; C Buri; S Schmid; F Egli; CU Brand; Christoph Mueller; Werner J Pichler; Lasse R Braathen
A comparative study of the expression of cytotoxic proteins in allergic contact dermatitis and psoriasis: spongiotic skin lesions in allergic contact dermatitis are highly infiltrated by T cells expressing perforin and granzyme B.
The American journal of pathology 2001;158(3):803-8.
2001: Werner J Pichler
Predictive drug allergy testing: an alternative viewpoint.
Toxicology 2001;158(1-2):31-41.
2001: Christoph Burkhart; Salome von Greyerz; Jan P H Depta; Dean J Naisbitt; Markus Britschgi; K B Park; Werner J Pichler
Influence of reduced glutathione on the proliferative response of sulfamethoxazole-specific and sulfamethoxazole-metabolite-specific human CD4+ T-cells.
British journal of pharmacology 2001;132(3):623-30.
2001: C B Neukomm; Nikhil Yawalkar; Arthur Helbling; Werner J Pichler
T-cell reactions to drugs in distinct clinical manifestations of drug allergy.
Journal of investigational allergology & clinical immunology : official organ of the International Association of Asthmology (INTERASMA) and Sociedad Latinoamericana de Alergia e Inmunología 2001;11(4):275-84.
2001: Nikhil Yawalkar; Werner J Pichler
Pathogenesis of drug-induced exanthema.
International archives of allergy and immunology 2001;124(1-3):336-8.
2000: A Winkler; Nikhil Yawalkar; Christiane Pichler; Werner J Pichler; Arthur Helbling
[Corticosteroid allergy: a paradox?].
Praxis 2000;89(49):2045-9.
2000: Nikhil Yawalkar; M Shrikhande; Y Hari; Helga Nievergelt; Lasse R Braathen; Werner J Pichler
Evidence for a role for IL-5 and eotaxin in activating and recruiting eosinophils in drug-induced cutaneous eruptions.
The Journal of allergy and clinical immunology 2000;106(6):1171-6.
2000: Arthur Helbling; Karl A Brander; Werner J Pichler; U B Müller
Anaphylactic shock after subcutaneous injection of mandragora D3, a homeopathic drug.
The Journal of allergy and clinical immunology 2000;106(5):989-90.
2000: Nikhil Yawalkar; Stephan Karlen; F Egli; CU Brand; H U Graber; Werner J Pichler; Lasse R Braathen
Down-regulation of IL-12 by topical corticosteroids in chronic atopic dermatitis.
The Journal of allergy and clinical immunology 2000;106(5):941-7.
2000: H Pfluger; A Helbling; C Mordasini; Werner J Pichler
[CVID (common variable immunodeficiency): heterogeneous clinical manifestation of the commonest symptomatic primary immunodeficiency disease].
Schweizerische medizinische Wochenschrift 2000;130(43):1590-9.
2000: Nikhil Yawalkar; Y Hari; K Frutig; F Egli; Thomas Wendland; Lasse R Braathen; Werner J Pichler
T cells isolated from positive epicutaneous test reactions to amoxicillin and ceftriaxone are drug specific and cytotoxic.
The Journal of investigative dermatology 2000;115(4):647-52.
2000: Werner J Pichler; Nikhil Yawalkar
Allergic reactions to drugs: involvement of T cells.
Thorax 2000;55 Suppl 2():S61-5.
2000: M Shrikhande; Thomas Hunziker; Lasse R Braathen; Werner J Pichler; Clemens Dahinden; Nikhil Yawalkar
Increased coexpression of eotaxin and interleukin 5 in bullous pemphigoid.
Acta dermato-venereologica 2000;80(4):277-80.
2000: B Schnyder; Christoph Burkhart; K Schnyder-Frutig; Salome von Greyerz; Dean J Naisbitt; Munir Pirmohamed; B Kevin Park; Werner J Pichler
Recognition of sulfamethoxazole and its reactive metabolites by drug-specific CD4+ T cells from allergic individuals.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(12):6647-54.
2000: Nikhil Yawalkar; F Egli; Y Hari; Helga Nievergelt; Lasse R Braathen; Werner J Pichler
Infiltration of cytotoxic T cells in drug-induced cutaneous eruptions.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2000;30(6):847-55.
2000: Thomas Wendland; Sylvia Herren; Nikhil Yawalkar; A Cerny; Werner J Pichler
Strong alpha beta and gamma delta TCR response in a patient with disseminated Mycobacterium avium infection and lack of NK cells and monocytopenia.
Immunology letters 2000;72(2):75-82.
2000: B Schnyder; Werner J Pichler
Skin and laboratory tests in amoxicillin- and penicillin-induced morbilliform skin eruption.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2000;30(4):590-5.
1999: O Arquint; Arthur Helbling; Reto Crameri; F Ferreira; M Breitenbach; Werner J Pichler
Reduced in vivo allergenicity of Bet v 1d isoform, a natural component of birch pollen.
The Journal of allergy and clinical immunology 1999;104(6):1239-43.
1999: Y Hari; A Urwyler; M Hurni; Nikhil Yawalkar; Clemens Dahinden; Thomas Wendland; Lasse R Braathen; Lukas Matter; Werner J Pichler
Distinct serum cytokine levels in drug- and measles-induced exanthema.
International archives of allergy and immunology 1999;120(3):225-9.
1999: C E Orasch; Arthur Helbling; MP Zanni; Nikhil Yawalkar; Y Hari; Werner J Pichler
T-cell reaction to local anaesthetics: relationship to angioedema and urticaria after subcutaneous application--patch testing and LTT in patients with adverse reaction to local anaesthetics.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1999;29(11):1549-54.
1999: B Fischer; Nikhil Yawalkar; Karl A Brander; Werner J Pichler; Arthur Helbling
Coprinus comatus (shaggy cap) is a potential source of aeroallergen that may provoke atopic dermatitis.
The Journal of allergy and clinical immunology 1999;104(4 Pt 1):836-41.
1999: Thomas Wendland; Hansjakob Furrer; Pietro L Vernazza; K Frutig; Anna Christen; Lukas Matter; RP Malinverni; Werner J Pichler
HAART in HIV-infected patients: restoration of antigen-specific CD4 T-cell responses in vitro is correlated with CD4 memory T-cell reconstitution, whereas improvement in delayed type hypersensitivity is related to a decrease in viraemia.
AIDS (London, England) 1999;13(14):1857-62.
1999: C Trachsel; Werner J Pichler; A Helbling
[Importance of laboratory investigations and trigger factors in chronic urticaria].
Schweizerische medizinische Wochenschrift 1999;129(36):1271-9.
1999: Karl A Brander; P Borbély; Reto Crameri; Werner J Pichler; Arthur Helbling
IgE-binding proliferative responses and skin test reactivity to Cop c 1, the first recombinant allergen from the basidiomycete Coprinus comatus.
The Journal of allergy and clinical immunology 1999;104(3 Pt 1):630-6.
1999: Salome von Greyerz; Christoph Burkhart; Werner J Pichler
Molecular basis of drug recognition by specific T-cell receptors.
International archives of allergy and immunology 1999;119(3):173-80.
1999: B Schnyder; Arthur Helbling; Werner J Pichler
Chronic idiopathic urticaria: natural course and association with Helicobacter pylori infection.
International archives of allergy and immunology 1999;119(1):60-3.
1999: Nikhil Yawalkar; Arthur Helbling; Christiane Pichler; L Zala; Werner J Pichler
T cell involvement in persulfate triggered occupational contact dermatitis and asthma.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 1999;82(4):401-4.
1999: Karl A Brander; Werner J Pichler; Arthur Helbling
Isolation of basidiomycete allergens.
International archives of allergy and immunology 1999;118(2-4):302-3.
1999: C Köchli; Thomas Wendland; K Frutig; R Grunow; S Merlin; Werner J Pichler
CD80 and CD86 costimulatory molecules on circulating T cells of HIV infected individuals.
Immunology letters 1999;65(3):197-201.
1999: MP Zanni; Salome von Greyerz; Y Hari; B Schnyder; Werner J Pichler
Recognition of local anesthetics by alphabeta+ T cells.
The Journal of investigative dermatology 1999;112(2):197-204.
1999: Werner J Pichler
Drug allergy: relationship between immunogenicity and clinical symptoms.
Allergy 1999;54 Suppl 58():5-7.
1999: Nikhil Yawalkar; Andrea Reimers; Y Hari; Thomas Hunziker; H Gerber; U Müller; Werner J Pichler
Drug-induced linear IgA bullous dermatosis associated with ceftriaxone- and metronidazole-specific T cells.
Dermatology (Basel, Switzerland) 1999;199(1):25-30.
1999: Salome von Greyerz; MP Zanni; K Frutig; B Schnyder; Christoph Burkhart; Werner J Pichler
Interaction of sulfonamide derivatives with the TCR of sulfamethoxazole-specific human alpha beta+ T cell clones.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(1):595-602.
1998: B Schnyder; K Frutig; D Mauri-Hellweg; A Limat; Nikhil Yawalkar; Werner J Pichler
T-cell-mediated cytotoxicity against keratinocytes in sulfamethoxazol-induced skin reaction.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1998;28(11):1412-7.
1998: Arthur Helbling; F Gayer; Werner J Pichler; Karl A Brander
Mushroom (Basidiomycete) allergy: diagnosis established by skin test and nasal challenge.
The Journal of allergy and clinical immunology 1998;102(5):853-8.
1998: Nikhil Yawalkar; Y Hari; A Helbing; Salome von Greyerz; A Kappeler; L R Baathen; Werner J Pichler
Elevated serum levels of interleukins 5, 6, and 10 in a patient with drug-induced exanthem caused by systemic corticosteroids.
Journal of the American Academy of Dermatology 1998;39(5 Pt 1):790-3.
1998: MP Zanni; Salome von Greyerz; B Schnyder; Karl A Brander; K Frutig; Y Hari; S Valitutti; Werner J Pichler
HLA-restricted, processing- and metabolism-independent pathway of drug recognition by human alpha beta T lymphocytes.
The Journal of clinical investigation 1998;102(8):1591-8.
1998: Salome von Greyerz; MP Zanni; B Schnyder; Werner J Pichler
Presentation of non-peptide antigens, in particular drugs, to specific T cells.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1998;28 Suppl 4():7-11.
1998: Andreas Cerny; Werner J Pichler
Allergy to antibacterials: the problem with beta-lactams and sulfonamides.
Pharmacoepidemiology and drug safety 1998;7 Suppl 1():S23-36.
1998: MP Zanni; B Schnyder; Salome von Greyerz; Werner J Pichler
Involvement of T cells in drug-induced allergies.
Trends in pharmacological sciences 1998;19(8):308-10.
1998: B Schnyder; Arthur Helbling; A Kappeler; Werner J Pichler
Drug-induced papulovesicular exanthema.
Allergy 1998;53(8):817-8.
1998: Hansjakob Furrer; Thomas Wendland; Christoph Minder; Anna Christen; J von Overbeck; R Grunow; Werner J Pichler; RP Malinverni
Association of syncytium-inducing phenotype of HIV-1 with CD4 cell count, viral load and sociodemographic characteristics.
AIDS (London, England) 1998;12(11):1341-6.
1998: Isabelle P Hunziker; Andreas Cerny; Werner J Pichler
Who is right? Or, how to judge the disagreement about HLA restriction of Nef peptides.
AIDS research and human retroviruses 1998;14(11):921-4.
1998: MP Zanni; Salome von Greyerz; B Schnyder; Thomas Wendland; Werner J Pichler
Allele-unrestricted presentation of lidocaine by HLA-DR molecules to specific alphabeta+ T cell clones.
International immunology 1998;10(4):507-15.
1998: Werner J Pichler; B Schnyder; MP Zanni; Y Hari; Salome von Greyerz
Role of T cells in drug allergies.
Allergy 1998;53(3):225-32.
1997: B O Gerber; MP Zanni; Mariagrazia Uguccioni; M Loetscher; CR Mackay; Werner J Pichler; Nikhil Yawalkar; Marco Baggiolini; Bernhard Moser
Functional expression of the eotaxin receptor CCR3 in T lymphocytes co-localizing with eosinophils.
Current biology : CB 1997;7(11):836-43.
1997: B Schnyder; D Mauri-Hellweg; MP Zanni; F Bettens; Werner J Pichler
Direct, MHC-dependent presentation of the drug sulfamethoxazole to human alphabeta T cell clones.
The Journal of clinical investigation 1997;100(1):136-41.
1997: Werner J Pichler; MP Zanni; Salome von Greyerz; B Schnyder; D Mauri-Hellweg; Thomas Wendland
High IL-5 production by human drug-specific T cell clones.
International archives of allergy and immunology 1997;113(1-3):177-80.
1997: C E Pichler; A Marquardsen; S Sparholt; H Løwenstein; Andreas J Bircher; M Bischof; Werner J Pichler
Specific immunotherapy with Dermatophagoides pteronyssinus and D. farinae results in decreased bronchial hyperreactivity.
Allergy 1997;52(3):274-83.
1997: B Schnyder; MP Zanni; Werner J Pichler
[Drug-induced hypersensitivity syndrome. A review and presentation of 2 personal cases].
Schweizerische medizinische Wochenschrift 1997;127(9):355-9.
1997: Werner J Pichler
[Regulation of the immune response: the TH1/TH2 concept].
Schweizerische medizinische Wochenschrift 1997;127(9):341-8.
1997: B Nyfeler; Werner J Pichler
The lymphocyte transformation test for the diagnosis of drug allergy: sensitivity and specificity.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1997;27(2):175-81.
1997: MP Zanni; D Mauri-Hellweg; C Brander; Thomas Wendland; B Schnyder; E Frei; Salome von Greyerz; Andreas J Bircher; Werner J Pichler
Characterization of lidocaine-specific T cells.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(3):1139-48.
1997: Werner J Pichler; B Schnyder; MP Zanni
Case 26-1996: hypersensitivity to carbamazepine.
The New England journal of medicine 1997;336(5):377.
1996: MP Zanni; Salome von Greyerz; B Schnyder; D Mauri-Hellweg; C Brander; C Kalbermatten; Werner J Pichler
T cell reactions in patients showing adverse immune reactions to drugs.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 1996;45 Suppl 2():S79-84.
1996: R Grunow; K Frutig; Werner J Pichler
Anergy induction in human CD4+ T-cell clones by stimulation with soluble peptides does not require cell proliferation and is accompanied by elevated IL4 production.
Cellular immunology 1996;173(1):79-86.
1996: M Jutel; U R Müller; M Fricker; S Rihs; Werner J Pichler; Clemens Dahinden
Influence of bee venom immunotherapy on degranulation and leukotriene generation in human blood basophils.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1996;26(10):1112-8.
1996: R Grunow; Jan von Overbeck; K Frutig; E Frei; D Germann; Hansjakob Furrer; L Perrin; Werner J Pichler
Inhibition of syncytia-inducing (SI) virus by autologous serum from HIV-1-infected individuals.
Clinical and diagnostic virology 1996;6(2-3):127-35.
1996: D Mauri-Hellweg; MP Zanni; E Frei; F Bettens; C Brander; D Mauri; E Padovan; Hans Ulrich Weltzien; Werner J Pichler
Cross-reactivity of T cell lines and clones to beta-lactam antibiotics.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(3):1071-9.
1996: C Brander; G Corradin; T Hasler; Werner J Pichler
Peptide immunization in humans: a combined CD8+/CD4+ T cell-targeted vaccine restimulates the memory CD4 T cell response but fails to induce cytotoxic T lymphocytes (CTL).
Clinical and experimental immunology 1996;105(1):18-25.
1996: Michael Seitz; M Perler; Werner J Pichler
Only weak association between disease severity and HLA-DRB 1 genes in a Swiss population of rheumatoid arthritis patients.
Rheumatology international 1996;16(1):9-13.
1996: E Padovan; D Mauri-Hellweg; Werner J Pichler; Hans Ulrich Weltzien
T cell recognition of penicillin G: structural features determining antigenic specificity.
European journal of immunology 1996;26(1):42-8.
1995: A von Schulthess; Werner J Pichler
[Delayed-type pressure urticaria].
Schweizerische medizinische Wochenschrift 1995;125(49):2387-90.
1995: M Jutel; D Skrbic; Werner J Pichler; U R Müller
Ultra rush bee venom immunotherapy does not reduce cutaneous weal responses to bee venom and codeine phosphate.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1995;25(12):1205-10.
1995: M Jutel; Tony Wyss-Coray; J M Carballido; K Blaser; U R Müller; Werner J Pichler
Selective restimulation of antigen or allergen preactivated T cells using OKT3 F(ab)2 results in the secretion of TH-1 or TH-2-like cytokine patterns.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1995;25(11):1108-17.
1995: R von Vigier; A L Sheffer; Werner J Pichler
[Exercise-induced urticaria and anaphylaxis].
Deutsche medizinische Wochenschrift (1946) 1995;120(41):1381-6.
1995: C Brander; D Mauri-Hellweg; F Bettens; H Rolli; M Goldman; Werner J Pichler
Heterogeneous T cell responses to beta-lactam-modified self-structures are observed in penicillin-allergic individuals.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(5):2670-8.
1995: C Brander; Werner J Pichler; G Corradin
Identification of HIV protein-derived cytotoxic T lymphocyte (CTL) epitopes for their possible use as synthetic vaccine.
Clinical and experimental immunology 1995;101(1):107-13.
1995: D Mauri-Hellweg; F Bettens; D Mauri; C Brander; Thomas Hunziker; Werner J Pichler
Activation of drug-specific CD4+ and CD8+ T cells in individuals allergic to sulfonamides, phenytoin, and carbamazepine.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(1):462-72.
1995: D Mauri; Tony Wyss-Coray; H Gallati; Werner J Pichler
Antigen-presenting T cells induce the development of cytotoxic CD4+ T cells. I. Involvement of the CD80-CD28 adhesion molecules.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(1):118-27.
1995: M Jutel; Werner J Pichler; D Skrbic; A Urwyler; Clemens Dahinden; U R Müller
Bee venom immunotherapy results in decrease of IL-4 and IL-5 and increase of IFN-gamma secretion in specific allergen-stimulated T cell cultures.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(8):4187-94.
1995: F Bettens; E Frei; K Frutig; D Mauri; Werner J Pichler; Tony Wyss-Coray
Noncytotoxic human CD4+ T-cell clones presenting and simultaneously responding to an antigen die of apoptosis.
Cellular immunology 1995;161(1):72-8.
1994: D Mauri; Tony Wyss-Coray; C Brander; Werner J Pichler
Improved sensitization of antigen-presenting cells with transferrin-bound peptides: advantages in competition for antigen presentation.
Cellular immunology 1994;158(1):59-70.
1994: C Pichler; Werner J Pichler
[Autoimmune progesterone dermatitis].
Deutsche medizinische Wochenschrift (1946) 1994;119(37):1258.
1994: Werner J Pichler; Tony Wyss-Coray
T cells as antigen-presenting cells.
Immunology today 1994;15(7):312-5.
1994: R Grunow; M D'Apuzzo; Tony Wyss-Coray; K Frutig; Werner J Pichler
A cell surface ELISA for the screening of monoclonal antibodies to antigens on viable cells in suspension.
Journal of immunological methods 1994;171(1):93-102.
1994: Werner J Pichler
[Drug allergy].
Therapeutische Umschau. Revue thérapeutique 1994;51(1):55-60.
1994: Werner J Pichler; C Brander; D Mauri; K Frutig; Tony Wyss-Coray
Peptide-induced T cell clones: specificity, MHC restriction, proliferation and cytokine pattern as a function of different stimulations.
Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt für Sera und Impfstoffe) zu Frankfurt a.M 1994;(87):141-53; discussion 153-4.
1993: C Brander; Tony Wyss-Coray; D Mauri; F Bettens; Werner J Pichler
Carrier-mediated uptake and presentation of a major histocompatibility complex class I-restricted peptide.
European journal of immunology 1993;23(12):3217-23.
1993: Tony Wyss-Coray; H Gallati; I Pracht; Alain Limat; D Mauri; K Frutig; Werner J Pichler
Antigen-presenting human T cells and antigen-presenting B cells induce a similar cytokine profile in specific T cell clones.
European journal of immunology 1993;23(12):3350-7.
1993: Tony Wyss-Coray; D Mauri-Hellweg; K Baumann; F Bettens; R Grunow; Werner J Pichler
The B7 adhesion molecule is expressed on activated human T cells: functional involvement in T-T cell interactions.
European journal of immunology 1993;23(9):2175-80.
1993: Werner J Pichler
[Diagnostic possibilities in drug allergies].
Schweizerische medizinische Wochenschrift 1993;123(23):1183-92.
1993: Werner J Pichler
[Drug allergies].
Wiener klinische Wochenschrift 1993;105(22):628-34.
1992: Werner J Pichler; P Campi
Allergy to lysozyme/egg white-containing vaginal suppositories.
Annals of allergy 1992;69(6):521-5.
1992: Tony Wyss-Coray; C Brander; K Frutig; Werner J Pichler
Discrimination of human CD4 T cell clones based on their reactivity with antigen-presenting T cells.
European journal of immunology 1992;22(9):2295-302.
1992: Michael Seitz; M Zwicker; Werner J Pichler; N Gerber
Activation and differentiation of myelomonocytic cells in rheumatoid arthritis and healthy individuals--evidence for antagonistic in vitro regulation by interferon-gamma and tumor necrosis factor alpha, granulocyte monocyte colony stimulating factor and interleukin 1.
The Journal of rheumatology 1992;19(7):1038-44.
1992: Tony Wyss-Coray; C Brander; F Bettens; D Mijic; Werner J Pichler
Use of antibody/peptide constructs of direct antigenic peptides to T cells: evidence for T cell processing and presentation.
Cellular immunology 1992;139(1):268-73.
1991: F Bettens; Werner J Pichler; Alain de Weck
Incorporation of biotinylated nucleotides for the quantification of PCR-amplified HIV-1 DNA by chemiluminescence.
European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies 1991;29(10):685-8.
1991: F Bettens; C E Pichler; B Herrmann; Alain de Weck; Werner J Pichler
Selective stimulation of CD4+ versus CD8+ T-cell subsets in symptomatic and asymptomatic HIV-1-infected individuals.
AIDS research and human retroviruses 1991;7(9):773-80.
1991: Tony Wyss-Coray; C Brander; F Bettens; D Mijic; Werner J Pichler
Use of antibodies as carriers for T-cell epitopes.
International archives of allergy and applied immunology 1991;94(1-4):187-8.
1990: Werner J Pichler
[Immunostimulants in chronic infection].
Schweizerische medizinische Wochenschrift 1990;120(24):898-902.
1990: Tony Wyss-Coray; F Bettens; C Walker; Werner J Pichler
Dichotomous effect of monocyte Fc receptor interaction on anti-CD3-induced immunoglobulin synthesis.
Cellular immunology 1990;126(1):91-105.
1990: F Bettens; C Walker; F E Maly; Werner J Pichler
Dual antibody stimulation: role of monocyte products and activation requirements of T cell subsets.
Cellular immunology 1990;125(1):130-41.
1989: C Walker; C Herzog; P Rieber; G Riethmüller; W Müller; Werner J Pichler
Anti-CD4 antibody treatment of patients with rheumatoid arthritis: II. Effect of in vivo treatment on in vitro proliferative response of CD4 cells.
Journal of autoimmunity 1989;2(5):643-9.
1989: Werner J Pichler; R Lehner; P J Späth
Recurrent angioedema associated with hypogonadism or anti-androgen therapy.
Annals of allergy 1989;63(4):301-5.
1989: F Bettens; C Walker; J F Gauchat; D Gauchat; Tony Wyss-Coray; Werner J Pichler
Lymphokine gene expression related to CD4 T cell subset (CD45R/CDw29) phenotype conversion.
European journal of immunology 1989;19(9):1569-74.
1989: S J Bell; Werner J Pichler
Penicillin-allergic patients react to penicillin-modified "self".
Allergy 1989;44(3):199-203.
1987: C Walker; F Bettens; Werner J Pichler
T cell activation by cross-linking anti-CD3 antibodies with second anti-T cell antibodies: dual antibody cross-linking mimics physical monocyte interaction.
European journal of immunology 1987;17(11):1611-8.