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Edgar Pick

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Publications

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Iris Dahan; Edgar Pick
Strategies for identifying synthetic peptides to act as inhibitors of NADPH oxidases, or "all that you did and did not want to know about Nox inhibitory peptides".
Iris Dahan; Shahar Molshanski-Mor; Edgar Pick
Inhibition of NADPH oxidase activation by peptides mapping within the dehydrogenase region of Nox2-A "peptide walking" study.
Ariel Mizrahi; Yevgeny Berdichevsky; Patrick J Casey; Edgar Pick
A prenylated p47phox-p67phox-Rac1 chimera is a Quintessential NADPH oxidase activator: membrane association and functional capacity.

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All Publications

2012: Iris Dahan; Edgar Pick
Strategies for identifying synthetic peptides to act as inhibitors of NADPH oxidases, or "all that you did and did not want to know about Nox inhibitory peptides".
Cellular and molecular life sciences : CMLS 2012;69(14):2283-305.
2012: Iris Dahan; Shahar Molshanski-Mor; Edgar Pick
Inhibition of NADPH oxidase activation by peptides mapping within the dehydrogenase region of Nox2-A "peptide walking" study.
Journal of leukocyte biology 2012;91(3):501-15.
2010: Ariel Mizrahi; Yevgeny Berdichevsky; Patrick J Casey; Edgar Pick
A prenylated p47phox-p67phox-Rac1 chimera is a Quintessential NADPH oxidase activator: membrane association and functional capacity.
The Journal of biological chemistry 2010;285(33):25485-99.
2010: Edgar Pick
Editorial: When charge is in charge--"Millikan" for leukocyte biologists.
Journal of leukocyte biology 2010;87(4):537-40.
2008: Yelena Ugolev; Yevgeny Berdichevsky; Carolyn Weinbaum; Edgar Pick
Dissociation of Rac1(GDP).RhoGDI complexes by the cooperative action of anionic liposomes containing phosphatidylinositol 3,4,5-trisphosphate, Rac guanine nucleotide exchange factor, and GTP.
The Journal of biological chemistry 2008;283(32):22257-71.
2007: Ross M Taylor; Connie I Lord; Marcia H Riesselman; Jeannie M Gripentrog; Thomas L Leto; Linda C McPhail; Yevgeny Berdichevsky; Edgar Pick; Algirdas J Jesaitis
Characterization of surface structure and p47phox SH3 domain-mediated conformational changes for human neutrophil flavocytochrome b.
Biochemistry 2007;46(49):14291-304.
2007: Marie-Claire Dagher; Edgar Pick
Opening the black box: lessons from cell-free systems on the phagocyte NADPH-oxidase.
Biochimie 2007;89(9):1123-32.
2007: Yevgeny Berdichevsky; Ariel Mizrahi; Yelena Ugolev; Shahar Molshanski-Mor; Edgar Pick
Tripartite chimeras comprising functional domains derived from the cytosolic NADPH oxidase components p47phox, p67phox, and Rac1 elicit activator-independent superoxide production by phagocyte membranes: an essential role for anionic membrane phospholipids.
The Journal of biological chemistry 2007;282(30):22122-39.
2007: Shahar Molshanski-Mor; Ariel Mizrahi; Yelena Ugolev; Iris Dahan; Yevgeny Berdichevsky; Edgar Pick
Cell-free assays: the reductionist approach to the study of NADPH oxidase assembly, or "all you wanted to know about cell-free assays but did not dare to ask".
Methods in molecular biology (Clifton, N.J.) 2007;412():385-428.
2006: Yelena Ugolev; Shahar Molshanski-Mor; Carolyn Weinbaum; Edgar Pick
Liposomes comprising anionic but not neutral phospholipids cause dissociation of Rac(1 or 2) x RhoGDI complexes and support amphiphile-independent NADPH oxidase activation by such complexes.
The Journal of biological chemistry 2006;281(28):19204-19.
2006: Ariel Mizrahi; Yevgeny Berdichevsky; Yelena Ugolev; Shahar Molshanski-Mor; Yael Nakash; Iris Dahan; Nathalie Alloul; Yara Gorzalczany; Rive Sarfstein; Miriam Hirshberg; Edgar Pick
Assembly of the phagocyte NADPH oxidase complex: chimeric constructs derived from the cytosolic components as tools for exploring structure-function relationships.
Journal of leukocyte biology 2006;79(5):881-95.
2005: Ariel Mizrahi; Shahar Molshanski-Mor; Carolyn Weinbaum; Yi Zheng; Miriam Hirshberg; Edgar Pick
Activation of the phagocyte NADPH oxidase by Rac Guanine nucleotide exchange factors in conjunction with ATP and nucleoside diphosphate kinase.
The Journal of biological chemistry 2005;280(5):3802-11.
2004: Rive Sarfstein; Yara Gorzalczany; Ariel Mizrahi; Yevgeny Berdichevsky; Shahar Molshanski-Mor; Carolyn Weinbaum; Miriam Hirshberg; Marie-Claire Dagher; Edgar Pick
Dual role of Rac in the assembly of NADPH oxidase, tethering to the membrane and activation of p67phox: a study based on mutagenesis of p67phox-Rac1 chimeras.
The Journal of biological chemistry 2004;279(16):16007-16.
2003: Natalia Sigal; Yara Gorzalczany; Edgar Pick
Two pathways of activation of the superoxide-generating NADPH oxidase of phagocytes in vitro--distinctive effects of inhibitors.
Inflammation 2003;27(3):147-59.
2003: Natalia Sigal; Yara Gorzalczany; Rive Sarfstein; Carolyn Weinbaum; Yi Zheng; Edgar Pick
The guanine nucleotide exchange factor trio activates the phagocyte NADPH oxidase in the absence of GDP to GTP exchange on Rac. "The emperor's nw clothes".
The Journal of biological chemistry 2003;278(7):4854-61.
2002: Yara Gorzalczany; Nathalie Alloul; Natalia Sigal; Carolyn Weinbaum; Edgar Pick
A prenylated p67phox-Rac1 chimera elicits NADPH-dependent superoxide production by phagocyte membranes in the absence of an activator and of p47phox: conversion of a pagan NADPH oxidase to monotheism.
The Journal of biological chemistry 2002;277(21):18605-10.
2002: Iris Dahan; Irina Issaeva; Yara Gorzalczany; Natalia Sigal; Miriam Hirshberg; Edgar Pick
Mapping of functional domains in the p22(phox) subunit of flavocytochrome b(559) participating in the assembly of the NADPH oxidase complex by "peptide walking".
The Journal of biological chemistry 2002;277(10):8421-32.
2001: Nathalie Alloul; Yara Gorzalczany; M Itan; Natalia Sigal; Edgar Pick
Activation of the superoxide-generating NADPH oxidase by chimeric proteins consisting of segments of the cytosolic component p67(phox) and the small GTPase Rac1.
Biochemistry 2001;40(48):14557-66.
2001: N Di-Poï; J Fauré; Sylvestre Grizot; Gergely Z Molnár; Edgar Pick; Marie-Claire Dagher
Mechanism of NADPH oxidase activation by the Rac/Rho-GDI complex.
Biochemistry 2001;40(34):10014-22.
2000: Yara Gorzalczany; Natalia Sigal; M Itan; Ofra Lotan; Edgar Pick
Targeting of Rac1 to the phagocyte membrane is sufficient for the induction of NADPH oxidase assembly.
The Journal of biological chemistry 2000;275(51):40073-81.
2000: James B Burritt; G N Fritel; Iris Dahan; Edgar Pick; D Roos; Algirdas J Jesaitis
Epitope identification for human neutrophil flavocytochrome b monoclonals 48 and 449.
European journal of haematology 2000;65(6):407-13.
1998: I Morozov; Ofra Lotan; G Joseph; Yara Gorzalczany; Edgar Pick
Mapping of functional domains in p47(phox) involved in the activation of NADPH oxidase by "peptide walking".
The Journal of biological chemistry 1998;273(25):15435-44.
1998: A Toporik; Yara Gorzalczany; Miriam Hirshberg; Edgar Pick; Ofra Lotan
Mutational analysis of novel effector domains in Rac1 involved in the activation of nicotinamide adenine dinucleotide phosphate (reduced) oxidase.
Biochemistry 1998;37(20):7147-56.
1998: Eli Gilad; Edgar Pick; Haim Matzkin; Nava Zisapel
Melatonin receptors in benign prostate epithelial cells: evidence for the involvement of cholera and pertussis toxins-sensitive G proteins in their signal transduction pathways.
The Prostate 1998;35(1):27-34.
1997: V Diatchuk; Ofra Lotan; V Koshkin; P Wikstroem; Edgar Pick
Inhibition of NADPH oxidase activation by 4-(2-aminoethyl)-benzenesulfonyl fluoride and related compounds.
The Journal of biological chemistry 1997;272(20):13292-301.
1997: V Koshkin; Ofra Lotan; Edgar Pick
Electron transfer in the superoxide-generating NADPH oxidase complex reconstituted in vitro.
Biochimica et biophysica acta 1997;1319(2-3):139-46.
1996: V Koshkin; Ofra Lotan; Edgar Pick
The cytosolic component p47(phox) is not a sine qua non participant in the activation of NADPH oxidase but is required for optimal superoxide production.
The Journal of biological chemistry 1996;271(48):30326-9.
1996: Eli Gilad; Moshe Laudon; Haim Matzkin; Edgar Pick; Mario Sofer; Z Braf; Nava Zisapel
Functional melatonin receptors in human prostate epithelial cells.
Endocrinology 1996;137(4):1412-7.
1995: G Joseph; Edgar Pick
"Peptide walking" is a novel method for mapping functional domains in proteins. Its application to the Rac1-dependent activation of NADPH oxidase.
The Journal of biological chemistry 1995;270(49):29079-82.
1994: G Joseph; Yara Gorzalczany; V Koshkin; Edgar Pick
Inhibition of NADPH oxidase activation by synthetic peptides mapping within the carboxyl-terminal domain of small GTP-binding proteins. Lack of amino acid sequence specificity and importance of polybasic motif.
The Journal of biological chemistry 1994;269(46):29024-31.
1994: Y Bromberg; E Shani; G Joseph; Yara Gorzalczany; Oded Sperling; Edgar Pick
The GDP-bound form of the small G protein Rac1 p21 is a potent activator of the superoxide-forming NADPH oxidase of macrophages.
The Journal of biological chemistry 1994;269(10):7055-8.
1994: V Koshkin; Edgar Pick
Superoxide production by cytochrome b559. Mechanism of cytosol-independent activation.
FEBS letters 1994;338(3):285-9.
1993: Edgar Pick; Yara Gorzalczany; S Engel
Role of the rac1 p21-GDP-dissociation inhibitor for rho heterodimer in the activation of the superoxide-forming NADPH oxidase of macrophages.
European journal of biochemistry / FEBS 1993;217(1):441-55.
1993: V Koshkin; Edgar Pick
Generation of superoxide by purified and relipidated cytochrome b559 in the absence of cytosolic activators.
FEBS letters 1993;327(1):57-62.
1991: A Abo; Edgar Pick
Purification and characterization of a third cytosolic component of the superoxide-generating NADPH oxidase of macrophages.
The Journal of biological chemistry 1991;266(35):23577-85.
1991: A Abo; Edgar Pick; Alan Hall; Nick Totty; C G Teahan; Anthony W Segal
Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1.
Nature 1991;353(6345):668-70.
1991: S Knoller; S Shpungin; Edgar Pick
The membrane-associated component of the amphiphile-activated, cytosol-dependent superoxide-forming NADPH oxidase of macrophages is identical to cytochrome b559.
The Journal of biological chemistry 1991;266(5):2795-804.
1990: I Aharoni; Edgar Pick
Activation of the superoxide-generating NADPH oxidase of macrophages by sodium dodecyl sulfate in a soluble cell-free system: evidence for involvement of a G protein.
Journal of leukocyte biology 1990;48(2):107-15.
1990: D Sha'ag; Edgar Pick
Nucleotide binding properties of cytosolic components required for expression of activity of the superoxide generating NADPH oxidase.
Biochimica et biophysica acta 1990;1037(3):405-12.
1989: Edgar Pick; T Kroizman; A Abo
Activation of the superoxide-forming NADPH oxidase of macrophages requires two cytosolic components--one of them is also present in certain nonphagocytic cells.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(12):4180-7.
1989: S Shpungin; I Dotan; A Abo; Edgar Pick
Activation of the superoxide forming NADPH oxidase in a cell-free system by sodium dodecyl sulfate. Absolute lipid dependence of the solubilized enzyme.
The Journal of biological chemistry 1989;264(16):9195-203.
1988: Edgar Pick; R Gadba
Certain lymphoid cells contain the membrane-associated component of the phagocyte-specific NADPH oxidase.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(5):1611-7.
1988: D Sha'ag; Edgar Pick
Macrophage-derived superoxide-generating NADPH oxidase in an amphiphile-activated, cell-free system; partial purification of the cytosolic component and evidence that it may contain the NADPH binding site.
Biochimica et biophysica acta 1988;952(2):213-9.
1987: Edgar Pick; Y Bromberg; S Shpungin; R Gadba
Activation of the superoxide forming NADPH oxidase in a cell-free system by sodium dodecyl sulfate. Characterization of the membrane-associated component.
The Journal of biological chemistry 1987;262(34):16476-83.
1986: Y Bromberg; D Sha'ag; S Shpungin; Edgar Pick
Activation of the superoxide forming NADPH oxidase in a macrophage-derived cell-free system by fatty acids and detergents.
Advances in prostaglandin, thromboxane, and leukotriene research 1986;16():153-63.
1985: Y Bromberg; Edgar Pick
Activation of NADPH-dependent superoxide production in a cell-free system by sodium dodecyl sulfate.
The Journal of biological chemistry 1985;260(25):13539-45.
1984: Y Bromberg; Edgar Pick
Unsaturated fatty acids stimulate NADPH-dependent superoxide production by cell-free system derived from macrophages.
Cellular immunology 1984;88(1):213-21.
1983: Y Bromberg; Edgar Pick
Unsaturated fatty acids as second messengers of superoxide generation by macrophages.
Cellular immunology 1983;79(2):240-52.
1981: Y Bromberg; Edgar Pick
Activation of macrophage adenylate cyclase by stimulants of the oxidative burst and by arachidonic acid--two distinct mechanisms.
Cellular immunology 1981;61(1):90-103.
1980: Y Bromberg; Edgar Pick
Cyclic GMP metabolism in macrophages. I. Regulation of cyclic GMP levels by calcium and stimulation of cyclic GMP synthesis by NO-generating agents.
Cellular immunology 1980;52(1):73-83.