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Edgar Pick

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

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Guinea Pigs

Physiology

Enzyme Activation

Anatomy

Genes & Molecular Sequences

Amino Acid Sequence

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Molecular Sequence Data

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Co-Publications
Name
13
Gorzalczany, Yara
6
Berdichevsky, Yevgeny
6
Lotan, Ofra
6
Molshanski-Mor, Shahar
6
Sigal, Natalia
6
Weinbaum, Carolyn
5
Ugolev, Yelena
5
Mizrahi, Ariel
5
Hirshberg, Miriam
4
Dahan, Iris
3
Alloul, Nathalie
3
Dagher, Marie-Claire
3
Sarfstein, Rive
2
Zisapel, Nava
2
Gilad, Eli

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Publications

TOP 3
Ugolev Yelena; Berdichevsky Yevgeny; Weinbaum Carolyn; Pick Edgar
Dissociation of Rac1(GDP).RhoGDI complexes by the cooperative action of anionic liposomes containing phosphatidylinositol 3,4,5-trisphosphate, Rac guanine nucleotide exchange factor, and GTP.
Taylor Ross M; Lord Connie I; Riesselman Marcia H; Gripentrog Jeannie M; Leto Thomas L; McPhail Linda C; Berdichevsky Yevgeny; Pick Edgar; Jesaitis Algirdas J
Characterization of surface structure and p47phox SH3 domain-mediated conformational changes for human neutrophil flavocytochrome b.
Dagher Marie-Claire; Pick Edgar
Opening the black box: lessons from cell-free systems on the phagocyte NADPH-oxidase.

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All Publications

2008: Ugolev Yelena; Berdichevsky Yevgeny; Weinbaum Carolyn; Pick Edgar
Dissociation of Rac1(GDP).RhoGDI complexes by the cooperative action of anionic liposomes containing phosphatidylinositol 3,4,5-trisphosphate, Rac guanine nucleotide exchange factor, and GTP.
The Journal of biological chemistry 2008;283(32):22257-71.
2007: Taylor Ross M; Lord Connie I; Riesselman Marcia H; Gripentrog Jeannie M; Leto Thomas L; McPhail Linda C; Berdichevsky Yevgeny; Pick Edgar; Jesaitis Algirdas J
Characterization of surface structure and p47phox SH3 domain-mediated conformational changes for human neutrophil flavocytochrome b.
Biochemistry 2007;46(49):14291-304.
2007: Dagher Marie-Claire; Pick Edgar
Opening the black box: lessons from cell-free systems on the phagocyte NADPH-oxidase.
Biochimie 2007;89(9):1123-32.
2007: Berdichevsky Yevgeny; Mizrahi Ariel; Ugolev Yelena; Molshanski-Mor Shahar; Pick Edgar
Tripartite chimeras comprising functional domains derived from the cytosolic NADPH oxidase components p47phox, p67phox, and Rac1 elicit activator-independent superoxide production by phagocyte membranes: an essential role for anionic membrane phospholipids.
The Journal of biological chemistry 2007;282(30):22122-39.
2007: Molshanski-Mor Shahar; Mizrahi Ariel; Ugolev Yelena; Dahan Iris; Berdichevsky Yevgeny; Pick Edgar
Cell-free assays: the reductionist approach to the study of NADPH oxidase assembly, or "all you wanted to know about cell-free assays but did not dare to ask".
Methods in molecular biology (Clifton, N.J.) 2007;412():385-428.
2006: Ugolev Yelena; Molshanski-Mor Shahar; Weinbaum Carolyn; Pick Edgar
Liposomes comprising anionic but not neutral phospholipids cause dissociation of Rac(1 or 2) x RhoGDI complexes and support amphiphile-independent NADPH oxidase activation by such complexes.
The Journal of biological chemistry 2006;281(28):19204-19.
2006: Mizrahi Ariel; Berdichevsky Yevgeny; Ugolev Yelena; Molshanski-Mor Shahar; Nakash Yael; Dahan Iris; Alloul Nathalie; Gorzalczany Yara; Sarfstein Rive; Hirshberg Miriam; Pick Edgar
Assembly of the phagocyte NADPH oxidase complex: chimeric constructs derived from the cytosolic components as tools for exploring structure-function relationships.
Journal of leukocyte biology 2006;79(5):881-95.
2005: Mizrahi Ariel; Molshanski-Mor Shahar; Weinbaum Carolyn; Zheng Yi; Hirshberg Miriam; Pick Edgar
Activation of the phagocyte NADPH oxidase by Rac Guanine nucleotide exchange factors in conjunction with ATP and nucleoside diphosphate kinase.
The Journal of biological chemistry 2005;280(5):3802-11.
2004: Sarfstein Rive; Gorzalczany Yara; Mizrahi Ariel; Berdichevsky Yevgeny; Molshanski-Mor Shahar; Weinbaum Carolyn; Hirshberg Miriam; Dagher Marie-Claire; Pick Edgar
Dual role of Rac in the assembly of NADPH oxidase, tethering to the membrane and activation of p67phox: a study based on mutagenesis of p67phox-Rac1 chimeras.
The Journal of biological chemistry 2004;279(16):16007-16.
2003: Sigal Natalia; Gorzalczany Yara; Pick Edgar
Two pathways of activation of the superoxide-generating NADPH oxidase of phagocytes in vitro--distinctive effects of inhibitors.
Inflammation 2003;27(3):147-59.
2003: Sigal Natalia; Gorzalczany Yara; Sarfstein Rive; Weinbaum Carolyn; Zheng Yi; Pick Edgar
The guanine nucleotide exchange factor trio activates the phagocyte NADPH oxidase in the absence of GDP to GTP exchange on Rac. "The emperor's nw clothes".
The Journal of biological chemistry 2003;278(7):4854-61.
2002: Gorzalczany Yara; Alloul Nathalie; Sigal Natalia; Weinbaum Carolyn; Pick Edgar
A prenylated p67phox-Rac1 chimera elicits NADPH-dependent superoxide production by phagocyte membranes in the absence of an activator and of p47phox: conversion of a pagan NADPH oxidase to monotheism.
The Journal of biological chemistry 2002;277(21):18605-10.
2002: Dahan Iris; Issaeva Irina; Gorzalczany Yara; Sigal Natalia; Hirshberg Miriam; Pick Edgar
Mapping of functional domains in the p22(phox) subunit of flavocytochrome b(559) participating in the assembly of the NADPH oxidase complex by "peptide walking".
The Journal of biological chemistry 2002;277(10):8421-32.
2001: Alloul N; Gorzalczany Y; Itan M; Sigal N; Pick E
Activation of the superoxide-generating NADPH oxidase by chimeric proteins consisting of segments of the cytosolic component p67(phox) and the small GTPase Rac1.
Biochemistry 2001;40(48):14557-66.
2001: Di-Poï N; Fauré J; Grizot S; Molnár G; Pick E; Dagher M C
Mechanism of NADPH oxidase activation by the Rac/Rho-GDI complex.
Biochemistry 2001;40(34):10014-22.
2000: Burritt J B; Fritel G N; Dahan I; Pick E; Roos D; Jesaitis A J
Epitope identification for human neutrophil flavocytochrome b monoclonals 48 and 449.
European journal of haematology 2000;65(6):407-13.
2000: Gorzalczany Y; Sigal N; Itan M; Lotan O; Pick E
Targeting of Rac1 to the phagocyte membrane is sufficient for the induction of NADPH oxidase assembly.
The Journal of biological chemistry 2000;275(51):40073-81.
1998: Morozov I; Lotan O; Joseph G; Gorzalczany Y; Pick E
Mapping of functional domains in p47(phox) involved in the activation of NADPH oxidase by "peptide walking".
The Journal of biological chemistry 1998;273(25):15435-44.
1998: Toporik A; Gorzalczany Y; Hirshberg M; Pick E; Lotan O
Mutational analysis of novel effector domains in Rac1 involved in the activation of nicotinamide adenine dinucleotide phosphate (reduced) oxidase.
Biochemistry 1998;37(20):7147-56.
1998: Gilad E; Pick E; Matzkin H; Zisapel N
Melatonin receptors in benign prostate epithelial cells: evidence for the involvement of cholera and pertussis toxins-sensitive G proteins in their signal transduction pathways.
The Prostate 1998;35(1):27-34.
1997: Diatchuk V; Lotan O; Koshkin V; Wikstroem P; Pick E
Inhibition of NADPH oxidase activation by 4-(2-aminoethyl)-benzenesulfonyl fluoride and related compounds.
The Journal of biological chemistry 1997;272(20):13292-301.
1997: Koshkin V; Lotan O; Pick E
Electron transfer in the superoxide-generating NADPH oxidase complex reconstituted in vitro.
Biochimica et biophysica acta 1997;1319(2-3):139-46.
1996: Koshkin V; Lotan O; Pick E
The cytosolic component p47(phox) is not a sine qua non participant in the activation of NADPH oxidase but is required for optimal superoxide production.
The Journal of biological chemistry 1996;271(48):30326-9.
1996: Gilad E; Laudon M; Matzkin H; Pick E; Sofer M; Braf Z; Zisapel N
Functional melatonin receptors in human prostate epithelial cells.
Endocrinology 1996;137(4):1412-7.
1995: Joseph G; Pick E
"Peptide walking" is a novel method for mapping functional domains in proteins. Its application to the Rac1-dependent activation of NADPH oxidase.
The Journal of biological chemistry 1995;270(49):29079-82.
1994: Joseph G; Gorzalczany Y; Koshkin V; Pick E
Inhibition of NADPH oxidase activation by synthetic peptides mapping within the carboxyl-terminal domain of small GTP-binding proteins. Lack of amino acid sequence specificity and importance of polybasic motif.
The Journal of biological chemistry 1994;269(46):29024-31.
1994: Bromberg Y; Shani E; Joseph G; Gorzalczany Y; Sperling O; Pick E
The GDP-bound form of the small G protein Rac1 p21 is a potent activator of the superoxide-forming NADPH oxidase of macrophages.
The Journal of biological chemistry 1994;269(10):7055-8.
1994: Koshkin V; Pick E
Superoxide production by cytochrome b559. Mechanism of cytosol-independent activation.
FEBS letters 1994;338(3):285-9.
1993: Pick E; Gorzalczany Y; Engel S
Role of the rac1 p21-GDP-dissociation inhibitor for rho heterodimer in the activation of the superoxide-forming NADPH oxidase of macrophages.
European journal of biochemistry / FEBS 1993;217(1):441-55.
1993: Koshkin V; Pick E
Generation of superoxide by purified and relipidated cytochrome b559 in the absence of cytosolic activators.
FEBS letters 1993;327(1):57-62.
1991: Abo A; Pick E
Purification and characterization of a third cytosolic component of the superoxide-generating NADPH oxidase of macrophages.
The Journal of biological chemistry 1991;266(35):23577-85.
1991: Abo A; Pick E; Hall A; Totty N; Teahan C G; Segal A W
Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1.
Nature 1991;353(6345):668-70.
1991: Knoller S; Shpungin S; Pick E
The membrane-associated component of the amphiphile-activated, cytosol-dependent superoxide-forming NADPH oxidase of macrophages is identical to cytochrome b559.
The Journal of biological chemistry 1991;266(5):2795-804.
1990: Aharoni I; Pick E
Activation of the superoxide-generating NADPH oxidase of macrophages by sodium dodecyl sulfate in a soluble cell-free system: evidence for involvement of a G protein.
Journal of leukocyte biology 1990;48(2):107-15.
1990: Sha'ag D; Pick E
Nucleotide binding properties of cytosolic components required for expression of activity of the superoxide generating NADPH oxidase.
Biochimica et biophysica acta 1990;1037(3):405-12.
1989: Pick E; Kroizman T; Abo A
Activation of the superoxide-forming NADPH oxidase of macrophages requires two cytosolic components--one of them is also present in certain nonphagocytic cells.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(12):4180-7.
1989: Shpungin S; Dotan I; Abo A; Pick E
Activation of the superoxide forming NADPH oxidase in a cell-free system by sodium dodecyl sulfate. Absolute lipid dependence of the solubilized enzyme.
The Journal of biological chemistry 1989;264(16):9195-203.
1988: Pick E; Gadba R
Certain lymphoid cells contain the membrane-associated component of the phagocyte-specific NADPH oxidase.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(5):1611-7.
1988: Sha'ag D; Pick E
Macrophage-derived superoxide-generating NADPH oxidase in an amphiphile-activated, cell-free system; partial purification of the cytosolic component and evidence that it may contain the NADPH binding site.
Biochimica et biophysica acta 1988;952(2):213-9.
1987: Pick E; Bromberg Y; Shpungin S; Gadba R
Activation of the superoxide forming NADPH oxidase in a cell-free system by sodium dodecyl sulfate. Characterization of the membrane-associated component.
The Journal of biological chemistry 1987;262(34):16476-83.
1986: Bromberg Y; Sha'ag D; Shpungin S; Pick E
Activation of the superoxide forming NADPH oxidase in a macrophage-derived cell-free system by fatty acids and detergents.
Advances in prostaglandin, thromboxane, and leukotriene research 1986;16():153-63.
1985: Bromberg Y; Pick E
Activation of NADPH-dependent superoxide production in a cell-free system by sodium dodecyl sulfate.
The Journal of biological chemistry 1985;260(25):13539-45.
1984: Bromberg Y; Pick E
Unsaturated fatty acids stimulate NADPH-dependent superoxide production by cell-free system derived from macrophages.
Cellular immunology 1984;88(1):213-21.
1983: Bromberg Y; Pick E
Unsaturated fatty acids as second messengers of superoxide generation by macrophages.
Cellular immunology 1983;79(2):240-52.
1981: Bromberg Y; Pick E
Activation of macrophage adenylate cyclase by stimulants of the oxidative burst and by arachidonic acid--two distinct mechanisms.
Cellular immunology 1981;61(1):90-103.
1980: Bromberg Y; Pick E
Cyclic GMP metabolism in macrophages. I. Regulation of cyclic GMP levels by calcium and stimulation of cyclic GMP synthesis by NO-generating agents.
Cellular immunology 1980;52(1):73-83.

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