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Derek Pickard

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Derek Pickard; Karthikeyan Sivaraman; Keith Turner; Michael Wetter; Christine Hale; Robert A Kingsley; Gemma Langridge; Gordon Dougan
A genomewide mutagenesis screen identifies multiple genes contributing to Vi capsular expression in Salmonella enterica serovar Typhi.
Evelien M Adriaenssens; Hany Anany; Bob Blasdel; Ian F Connerton; David Goulding; Mansel W Griffiths; Steven P Hooton; Andrew M Kropinski; Elizabeth M Kutter; Ju-Hoon Lee; Martine Maes; Derek Pickard; Sangryeol Ryu; Zargham Sepehrizadeh; S Sabouri Shahrbabak; Ana Toribio; Hans-Wolfgang Ackermann; Rob Lavigne
A suggested new bacteriophage genus: "Viunalikevirus".
Nicola K Petty; Theresa Feltwell; Derek Pickard; Simon Clare; Ana Toribio; Maria Fookes; Kevin Roberts; Rita Monson; Satheesh Nair; Robert Kingsley; Richard Bulgin; Siouxsie Wiles; David Goulding; Thomas Keane; Craig Corton; Nicola Lennard; David Harris; David Willey; Richard Rance; Lu Yu; Jyoti S Choudhary; Carol Churcher; Michael A Quail; Julian Parkhill; Gad Frankel; Gordon Dougan; George P C Salmond; Nicholas R Thomson
Citrobacter rodentium is an unstable pathogen showing evidence of significant genomic flux.

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2013: Derek Pickard; Karthikeyan Sivaraman; Keith Turner; Michael Wetter; Christine Hale; Robert A Kingsley; Gemma Langridge; Gordon Dougan
A genomewide mutagenesis screen identifies multiple genes contributing to Vi capsular expression in Salmonella enterica serovar Typhi.
Journal of bacteriology 2013;195(6):1320-6.
2012: Evelien M Adriaenssens; Hany Anany; Bob Blasdel; Ian F Connerton; David Goulding; Mansel W Griffiths; Steven P Hooton; Andrew M Kropinski; Elizabeth M Kutter; Ju-Hoon Lee; Martine Maes; Derek Pickard; Sangryeol Ryu; Zargham Sepehrizadeh; S Sabouri Shahrbabak; Ana Toribio; Hans-Wolfgang Ackermann; Rob Lavigne
A suggested new bacteriophage genus: "Viunalikevirus".
Archives of virology 2012;157(10):2035-46.
2011: Nicola K Petty; Theresa Feltwell; Derek Pickard; Simon Clare; Ana Toribio; Maria Fookes; Kevin Roberts; Rita Monson; Satheesh Nair; Robert Kingsley; Richard Bulgin; Siouxsie Wiles; David Goulding; Thomas Keane; Craig Corton; Nicola Lennard; David Harris; David Willey; Richard Rance; Lu Yu; Jyoti S Choudhary; Carol Churcher; Michael A Quail; Julian Parkhill; Gad Frankel; Gordon Dougan; George P C Salmond; Nicholas R Thomson
Citrobacter rodentium is an unstable pathogen showing evidence of significant genomic flux.
PLoS pathogens 2011;7(4):e1002018.
2010: Derek Pickard; Ana Toribio; Nicola K Petty; Andries van Tonder; Lu Yu; David Goulding; Bart Barrell; Richard Rance; David Harris; Michael Wetter; John Wain; Jyoti Choudhary; Nicholas Thomson; Gordon Dougan
A conserved acetyl esterase domain targets diverse bacteriophages to the Vi capsular receptor of Salmonella enterica serovar Typhi.
Journal of bacteriology 2010;192(21):5746-54.
2009: Lindsay Hall; Simon Clare; Derek Pickard; Simon O Clark; Dominic L F Kelly; Moataz Abd El Ghany; Christine Hale; Jes Dietrich; Peter Andersen; Philip D Marsh; Gordon Dougan
Characterisation of a live Salmonella vaccine stably expressing the Mycobacterium tuberculosis Ag85B-ESAT6 fusion protein.
Vaccine 2009;27(49):6894-904.
2009: Trevor D Lawley; Nicholas J Croucher; Lu Yu; Simon Clare; Mohammed Sebaihia; David Goulding; Derek Pickard; Julian Parkhill; Jyoti Choudhary; Gordon Dougan
Proteomic and genomic characterization of highly infectious Clostridium difficile 630 spores.
Journal of bacteriology 2009;191(17):5377-86.
2009: Timothy T Perkins; Robert Kingsley; Maria C Fookes; Paul P Gardner; Keith D James; Lu Yu; Samuel A Assefa; Miao He; Nicholas J Croucher; Derek Pickard; Duncan J Maskell; Julian Parkhill; Jyoti Choudhary; Nicholas R Thomson; Gordon Dougan
A strand-specific RNA-Seq analysis of the transcriptome of the typhoid bacillus Salmonella typhi.
PLoS genetics 2009;5(7):e1000569.
2008: Fiona J Cooke; Derek Brown; Maria Fookes; Derek Pickard; Alasdair Ivens; John Wain; Mark Roberts; Robert Kingsley; Nicholas R Thomson; Gordon Dougan
Characterization of the genomes of a diverse collection of Salmonella enterica serovar Typhimurium definitive phage type 104.
Journal of bacteriology 2008;190(24):8155-62.
2008: Stephen Baker; Derek Pickard; Sally Whitehead; Jeremy Farrar; Gordon Dougan
Mobilization of the incQ plasmid R300B with a chromosomal conjugation system in Salmonella enterica serovar typhi.
Journal of bacteriology 2008;190(11):4084-7.
2008: Derek Pickard; Nicholas R Thomson; Stephen Baker; John Wain; Mercedes Pardo; David Goulding; Nancy Hamlin; Jyoti Choudhary; John Threfall; Gordon Dougan
Molecular characterization of the Salmonella enterica serovar Typhi Vi-typing bacteriophage E1.
Journal of bacteriology 2008;190(7):2580-7.
2007: Moataz Abd El Ghany; Angela Jansen; Simon Clare; Lindsay Hall; Derek Pickard; Robert Kingsley; Gordon Dougan
Candidate live, attenuated Salmonella enterica serotype Typhimurium vaccines with reduced fecal shedding are immunogenic and effective oral vaccines.
Infection and immunity 2007;75(4):1835-42.
2006: Christine Hale; Frances Bowe; Derek Pickard; Simon Clare; Jean-François Haeuw; Ultan Powers; Nathalie Menager; Pietro Mastroeni; Gordon Dougan
Evaluation of a novel Vi conjugate vaccine in a murine model of salmonellosis.
Vaccine 2006;24(20):4312-20.
2005: R J Cahill; S Tan; Gordon Dougan; Peadar Ó Gaora; Derek Pickard; Nigel L Kennea; M H F Sullivan; Robert G Feldman; A David Edwards
Universal DNA primers amplify bacterial DNA from human fetal membranes and link Fusobacterium nucleatum with prolonged preterm membrane rupture.
Molecular human reproduction 2005;11(10):761-6.
2005: Anne L Bishop; Stephen Baker; Sara Jenks; Maria Fookes; Peadar Ó Gaora; Derek Pickard; Muna F Anjum; Jeremy Farrar; Tran Tinh Hien; Alasdair Ivens; Gordon Dougan
Analysis of the hypervariable region of the Salmonella enterica genome associated with tRNA(leuX).
Journal of bacteriology 2005;187(7):2469-82.
2004: Christine Hale; Ian R Humphreys; Tracy Hussell; Frances Bowe; Simon Clare; Derek Pickard; Andrew Preston; Giuseppe Del Giudice; Gordon Dougan
Mucosal immunisation of murine neonates using whole cell and acellular Pertussis vaccines.
Vaccine 2004;22(27-28):3595-602.
2004: Nicola D Mckelvie; Richard Stratford; Tao Wu; Trevor Bellaby; Emma Aldred; Nicky Hughes; Steven N Chatfield; Derek Pickard; Christine Hale; Gordon Dougan; Shahid A Khan
Expression of heterologous antigens in Salmonella Typhimurium vaccine vectors using the in vivo-inducible, SPI-2 promoter, ssaG.
Vaccine 2004;22(25-26):3243-55.
2004: Nicholas Thomson; Stephen Baker; Derek Pickard; Maria Fookes; Muna F Anjum; Nancy Hamlin; John Wain; Deborah House; Zulfiqar A Bhutta; Kaman Chan; Stanley Falkow; Julian Parkhill; Martin Woodward; Alasdair Ivens; Gordon Dougan
The role of prophage-like elements in the diversity of Salmonella enterica serovars.
Journal of molecular biology 2004;339(2):279-300.
2003: Derek Pickard; John Wain; Stephen Baker; Alexandra Line; Sonia Chohan; Maria Fookes; Andrew Barron; Peadar Ó Gaora; José A Chabalgoity; Niren Thanky; Christoph Scholes; Nicholas Thomson; Michael A Quail; Julian Parkhill; Gordon Dougan
Composition, acquisition, and distribution of the Vi exopolysaccharide-encoding Salmonella enterica pathogenicity island SPI-7.
Journal of bacteriology 2003;185(17):5055-65.
2003: Rosanna Mundy; Derek Pickard; Rebecca K Wilson; Cameron P Simmons; Gordon Dougan; Gad Frankel
Identification of a novel type IV pilus gene cluster required for gastrointestinal colonization of Citrobacter rodentium.
Molecular microbiology 2003;48(3):795-809.
2003: Shahid A Khan; Richard Stratford; Tao Wu; Nicola D Mckelvie; Trevor Bellaby; Zoë Hindle; Katharine A Sinha; Shayne Eltze; Pietro Mastroeni; Derek Pickard; Gordon Dougan; Steven N Chatfield; Frank R Brennan
Salmonella typhi and S typhimurium derivatives harbouring deletions in aromatic biosynthesis and Salmonella Pathogenicity Island-2 (SPI-2) genes as vaccines and vectors.
Vaccine 2003;21(5-6):538-48.
2003: Frances Bowe; Derek Pickard; Richard J Anderson; Patricia Londoño-Arcila; Gordon Dougan
Development of attenuated Salmonella strains that express heterologous antigens.
Methods in molecular medicine 2003;87():83-100.
2002: Zoë Hindle; Steven N Chatfield; Jo Phillimore; Matthew Bentley; Julie Johnson; Catherine Cosgrove; Marjan Ghaem-Maghami; Amy Sexton; Mohammad Khan; Frank R Brennan; Paul Everest; Tao Wu; Derek Pickard; David W Holden; Gordon Dougan; George E Griffin; Deborah House; Joseph D Santangelo; Shahid A Khan; Jaqueline E Shea; Robert G Feldman; David J M Lewis
Characterization of Salmonella enterica derivatives harboring defined aroC and Salmonella pathogenicity island 2 type III secretion system (ssaV) mutations by immunization of healthy volunteers.
Infection and immunity 2002;70(7):3457-67.
2002: Claire Kidgell; Derek Pickard; John Wain; Keith James; L T Diem Nga; To Song Diep; Myron M Levine; Peadar Ó Gaora; Michael B Prentice; Julian Parkhill; Nicholas Day; Jeremy Farrar; Gordon Dougan
Characterisation and distribution of a cryptic Salmonella typhi plasmid pHCM2.
Plasmid 2002;47(3):159-71.
2001: John Wain; Deborah House; Derek Pickard; Gordon Dougan; Gad Frankel
Acquisition of virulence-associated factors by the enteric pathogens Escherichia coli and Salmonella enterica.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2001;356(1411):1027-34.
2001: Michael B Prentice; Keith D James; Julian Parkhill; S G Baker; Kim Stevens; M N Simmonds; Karen Mungall; Carol Churcher; Petra C F Oyston; Richard Titball; Brendan W Wren; John Wain; Derek Pickard; Tran Tinh Hien; J J Farrar; Gordon Dougan
Yersinia pestis pFra shows biovar-specific differences and recent common ancestry with a Salmonella enterica serovar Typhi plasmid.
Journal of bacteriology 2001;183(8):2586-94.
2001: Gordon Dougan; A Haque; Derek Pickard; Gad Frankel; Peadar Ó Gaora; John Wain
The Escherichia coli gene pool.
Current opinion in microbiology 2001;4(1):90-4.
2000: Gordon Dougan; Marjan Ghaem-Maghami; Derek Pickard; Gad Frankel; G Douce; Simon Clare; Sarah J Dunstan; Cameron Simmons
The immune responses to bacterial antigens encountered in vivo at mucosal surfaces.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2000;355(1397):705-12.
1999: DC Lowe; Tor C Savidge; Derek Pickard; Lars Eckmann; Martin F Kagnoff; Gordon Dougan; Steven N Chatfield
Characterization of candidate live oral Salmonella typhi vaccine strains harboring defined mutations in aroA, aroC, and htrA.
Infection and immunity 1999;67(2):700-7.
1998: P Vaithanomsat; S Sangiambut; Derek Pickard; Neil Fairweather; Katherine A Brown
Construction of a Pseudomonas aeruginosa cosmid library.
Biochemical Society transactions 1998;26(3):S282.
1997: Carol O Tacket; Marcelo B Sztein; Genevieve A Losonsky; Steven Wasserman; James P Nataro; Robert Edelman; Derek Pickard; Gordon Dougan; Steven N Chatfield; Myron M Levine
Safety of live oral Salmonella typhi vaccine strains with deletions in htrA and aroC aroD and immune response in humans.
Infection and immunity 1997;65(2):452-6.
1996: R J Anderson; L P Londoño; Derek Pickard; Gordon Dougan
Development of Attenuated Salmonella Strains that Express Heterologous Antigens.
Methods in molecular medicine 1996;4():47-62.
1994: Ian G Charles; Neil Fairweather; Derek Pickard; J Beesley; R Anderson; Gordon Dougan; M Roberts
Expression of the Bordetella pertussis P.69 pertactin adhesin in Escherichia coli: fate of the carboxy-terminal domain.
Microbiology (Reading, England) 1994;140 ( Pt 12)():3301-8.
1994: Derek Pickard; J Li; Mark Roberts; Duncan J Maskell; David Hone; Myron M Levine; Gordon Dougan; Steven N Chatfield
Characterization of defined ompR mutants of Salmonella typhi: ompR is involved in the regulation of Vi polysaccharide expression.
Infection and immunity 1994;62(9):3984-93.
1994: JA Harrison; Derek Pickard; Christopher F Higgins; A Khan; Steven N Chatfield; T Ali; Charles J Dorman; Carlos E Hormaeche; Gordon Dougan
Role of hns in the virulence phenotype of pathogenic salmonellae.
Molecular microbiology 1994;13(1):133-40.
1992: Steven N Chatfield; Ian G Charles; A J Makoff; M D Oxer; Gordon Dougan; Derek Pickard; D Slater; Neil Fairweather
Use of the nirB promoter to direct the stable expression of heterologous antigens in Salmonella oral vaccine strains: development of a single-dose oral tetanus vaccine.
Bio/technology (Nature Publishing Company) 1992;10(8):888-92.
1992: Steven N Chatfield; K Strahan; Derek Pickard; Ian G Charles; Carlos E Hormaeche; Gordon Dougan
Evaluation of Salmonella typhimurium strains harbouring defined mutations in htrA and aroA in the murine salmonellosis model.
Microbial pathogenesis 1992;12(2):145-51.
1992: Steven N Chatfield; Neil Fairweather; Ian G Charles; Derek Pickard; Myron M Levine; David Hone; M Posada; R A Strugnell; Gordon Dougan
Construction of a genetically defined Salmonella typhi Ty2 aroA, aroC mutant for the engineering of a candidate oral typhoid-tetanus vaccine.
Vaccine 1992;10(1):53-60.
1991: M Roberts; Neil Fairweather; E Leininger; Derek Pickard; E L Hewlett; A Robinson; C Hayward; Gordon Dougan; Ian G Charles
Construction and characterization of Bordetella pertussis mutants lacking the vir-regulated P.69 outer membrane protein.
Molecular microbiology 1991;5(6):1393-404.
1991: Ian G Charles; J L Li; M Roberts; K Beesley; Mike Romanos; Derek Pickard; M Francis; D Campbell; Gordon Dougan; M J Brennan
Identification and characterization of a protective immunodominant B cell epitope of pertactin (P.69) from Bordetella pertussis.
European journal of immunology 1991;21(5):1147-53.
1991: K Johnson; Ian G Charles; Gordon Dougan; Derek Pickard; Peadar Ó Gaora; G Costa; T Ali; I Miller; Carlos E Hormaeche
The role of a stress-response protein in Salmonella typhimurium virulence.
Molecular microbiology 1991;5(2):401-7.
1991: S Servos; Steven N Chatfield; David Hone; Myron M Levine; G Dimitriadis; Derek Pickard; Gordon Dougan; Neil Fairweather; Ian G Charles
Molecular cloning and characterization of the aroD gene encoding 3-dehydroquinase from Salmonella typhi.
Journal of general microbiology 1991;137(1):147-52.
1990: K S Johnson; Ian G Charles; Gordon Dougan; I A Miller; Derek Pickard; Peadar Ó Gaora; G Costa; T Ali; Carlos E Hormaeche
The role of a stress-response protein in bacterial virulence.
Research in microbiology 1990;141(7-8):823-5.
1990: R A Strugnell; Duncan J Maskell; Neil Fairweather; Derek Pickard; Alan Cockayne; C Penn; Gordon Dougan
Stable expression of foreign antigens from the chromosome of Salmonella typhimurium vaccine strains.
Gene 1990;88(1):57-63.
1990: Ian G Charles; Heather K Lamb; Derek Pickard; Gordon Dougan; Alastair R Hawkins
Isolation, characterization and nucleotide sequences of the aroC genes encoding chorismate synthase from Salmonella typhi and Escherichia coli.
Journal of general microbiology 1990;136(2):353-8.
1989: I Miller; Duncan J Maskell; Carlos E Hormaeche; K Johnson; Derek Pickard; Gordon Dougan
Isolation of orally attenuated Salmonella typhimurium following TnphoA mutagenesis.
Infection and immunity 1989;57(9):2758-63.
1989: Ian G Charles; Gordon Dougan; Derek Pickard; Steven N Chatfield; M Smith; P Novotny; P Morrissey; Neil Fairweather
Molecular cloning and characterization of protective outer membrane protein P.69 from Bordetella pertussis.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(10):3554-8.
1989: D Leslie; Neil Fairweather; Derek Pickard; Gordon Dougan; M Kehoe
Phospholipase C and haemolytic activities of Clostridium perfringens alpha-toxin cloned in Escherichia coli: sequence and homology with a Bacillus cereus phospholipase C.
Molecular microbiology 1989;3(3):383-92.
1988: Gordon Dougan; Steven N Chatfield; Derek Pickard; J Bester; D O'Callaghan; Duncan J Maskell
Construction and characterization of vaccine strains of Salmonella harboring mutations in two different aro genes.
The Journal of infectious diseases 1988;158(6):1329-35.
1988: Ian G Charles; Gordon Dougan; Derek Pickard; S Charfield; M Smith; P Novotny; Neil Fairweather
Molecular cloning and analysis of P. 69, a vir-controlled protein from Bordetella pertussis.
The Tokai journal of experimental and clinical medicine 1988;13 Suppl():227-34.
1987: Gordon Dougan; Duncan J Maskell; Derek Pickard; Carlos E Hormaeche
Isolation of stable aroA mutants of Salmonella typhi Ty2: properties and preliminary characterisation in mice.
Molecular & general genetics : MGG 1987;207(2-3):402-5.
1986: Neil Fairweather; V A Lyness; Derek Pickard; G Allen; R O Thomson
Cloning, nucleotide sequencing, and expression of tetanus toxin fragment C in Escherichia coli.
Journal of bacteriology 1986;165(1):21-7.