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Cecile Pickart

Research Profile

Chemicals & Drugs

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Candice M Carlile; Cecile M Pickart; Michael J Matunis; Robert E Cohen
Synthesis of free and proliferating cell nuclear antigen-bound polyubiquitin chains by the RING E3 ubiquitin ligase Rad5.
Eric M Cooper; Colleen Cutcliffe; Troels Z Kristiansen; Akhilesh Pandey; Cecile M Pickart; Robert E Cohen
K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1.
Tao Wang; Luming Yin; Eric M Cooper; Ming-Yih Lai; Seth Dickey; Cecile M Pickart; David Fushman; Keith Wilkinson; Robert E Cohen; Cynthia Wolberger
Evidence for bidentate substrate binding as the basis for the K48 linkage specificity of otubain 1.

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All Publications

2009: Candice M Carlile; Cecile M Pickart; Michael J Matunis; Robert E Cohen
Synthesis of free and proliferating cell nuclear antigen-bound polyubiquitin chains by the RING E3 ubiquitin ligase Rad5.
The Journal of biological chemistry 2009;284(43):29326-34.
2009: Eric M Cooper; Colleen Cutcliffe; Troels Z Kristiansen; Akhilesh Pandey; Cecile M Pickart; Robert E Cohen
K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1.
The EMBO journal 2009;28(6):621-31.
2009: Tao Wang; Luming Yin; Eric M Cooper; Ming-Yih Lai; Seth Dickey; Cecile M Pickart; David Fushman; Keith Wilkinson; Robert E Cohen; Cynthia Wolberger
Evidence for bidentate substrate binding as the basis for the K48 linkage specificity of otubain 1.
Journal of molecular biology 2009;386(4):1011-23.
2008: Dongren Yang; Angela Howard; Donald Bruun; Mispa Ajua-Alemanj; Cecile M Pickart; Pamela J Lein
Chlorpyrifos and chlorpyrifos-oxon inhibit axonal growth by interfering with the morphogenic activity of acetylcholinesterase.
Toxicology and applied pharmacology 2008;228(1):32-41.
2008: Jin-Ying Lu; Yu-Yi Lin; Jiang Qian; Sheng-Ce Tao; Jian Zhu; Cecile M Pickart; Heng Zhu
Functional dissection of a HECT ubiquitin E3 ligase.
Molecular & cellular proteomics : MCP 2008;7(1):35-45.
2007: Xiao-Jun Yin; Sara Volk; Karin Ljung; Norbert Mehlmer; Karel Dolezal; Franck Ditengou; Shigeru Hanano; Simon J Davis; Elmon Schmelzer; Göran Sandberg; Markus Teige; Klaus Palme; Cecile M Pickart; Andreas Bachmair
Ubiquitin lysine 63 chain forming ligases regulate apical dominance in Arabidopsis.
The Plant cell 2007;19(6):1898-911.
2007: Michael J Eddins; Ranjani Varadan; David Fushman; Cecile M Pickart; Cynthia Wolberger
Crystal structure and solution NMR studies of Lys48-linked tetraubiquitin at neutral pH.
Journal of molecular biology 2007;367(1):204-11.
2006: Michael J Eddins; Candice M Carlile; Kamila M Gomez; Cecile M Pickart; Cynthia Wolberger
Mms2-Ubc13 covalently bound to ubiquitin reveals the structural basis of linkage-specific polyubiquitin chain formation.
Nature structural & molecular biology 2006;13(10):915-20.
2006: Ariel Stanhill; Cole Haynes; Yuhong Zhang; Guangwei Min; Matthew C Steele; Juliya Kalinina; Enid Martinez; Cecile M Pickart; Xiang-Peng Kong; David Ron
An arsenite-inducible 19S regulatory particle-associated protein adapts proteasomes to proteotoxicity.
Molecular cell 2006;23(6):875-85.
2006: Dennis Flierman; Catherine S Coleman; Cecile M Pickart; Tom A Rapoport; Vincent Chau
E2-25K mediates US11-triggered retro-translocation of MHC class I heavy chains in a permeabilized cell system.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(31):11589-94.
2006: Dongxia Wang; Dario E Kalume; Cecile M Pickart; Akhilesh Pandey; Robert J Cotter
Identification of protein ubiquitylation by electrospray ionization tandem mass spectrometric analysis of sulfonated tryptic peptides.
Analytical chemistry 2006;78(11):3681-7.
2006: Min Wang; Dongmei Cheng; Junmin Peng; Cecile M Pickart
Molecular determinants of polyubiquitin linkage selection by an HECT ubiquitin ligase.
The EMBO journal 2006;25(8):1710-9.
2005: Min Wang; Cecile M Pickart
Different HECT domain ubiquitin ligases employ distinct mechanisms of polyubiquitin chain synthesis.
The EMBO journal 2005;24(24):4324-33.
2005: Shahri Raasi; Ranjani Varadan; David Fushman; Cecile M Pickart
Diverse polyubiquitin interaction properties of ubiquitin-associated domains.
Nature structural & molecular biology 2005;12(8):708-14.
2005: Michael J Matunis; Cecile M Pickart
Beginning at the end with SUMO.
Nature structural & molecular biology 2005;12(7):565-6.
2005: Ranjani Varadan; Michael Assfalg; Shahri Raasi; Cecile M Pickart; David Fushman
Structural determinants for selective recognition of a Lys48-linked polyubiquitin chain by a UBA domain.
Molecular cell 2005;18(6):687-98.
2005: Colleen Tsui; Arani Raguraj; Cecile M Pickart
Ubiquitin binding site of the ubiquitin E2 variant (UEV) protein Mms2 is required for DNA damage tolerance in the yeast RAD6 pathway.
The Journal of biological chemistry 2005;280(20):19829-35.
2005: Cecile M Pickart; Shahri Raasi
Controlled synthesis of polyubiquitin chains.
Methods in enzymology 2005;399():21-36.
2005: Sara Volk; Min Wang; Cecile M Pickart
Chemical and genetic strategies for manipulating polyubiquitin chain structure.
Methods in enzymology 2005;399():3-20.
2005: Shahri Raasi; Cecile M Pickart
Ubiquitin chain synthesis.
Methods in molecular biology (Clifton, N.J.) 2005;301():47-55.
2004: Christopher A Ross; Cecile M Pickart
The ubiquitin-proteasome pathway in Parkinson's disease and other neurodegenerative diseases.
Trends in cell biology 2004;14(12):703-11.
2004: Cecile M Pickart; David Fushman
Polyubiquitin chains: polymeric protein signals.
Current opinion in chemical biology 2004;8(6):610-6.
2004: Cecile M Pickart; Michael J Eddins
Ubiquitin: structures, functions, mechanisms.
Biochimica et biophysica acta 2004;1695(1-3):55-72.
2004: Wolfgang Baumeister; Andreas Bachmair; Vincent Chau; Robert E Cohen; Philip Coffino; George Demartino; Raymond J Deshaies; Juergen Dohmen; Scott Emr; Daniel Finley; Randy Hampton; Christopher Hill; Mark Hochstrasser; Robert Huber; Peter Jackson; Stefan Jentsch; Erica Johnson; Yong Tae Kwon; Michele Pagano; Cecile M Pickart; Martin Rechsteiner; Martin Scheffner; Thomas Sommer; William Tansey; Mike Tyers; Richard D Vierstra; Allan Weissman; Keith Wilkinson; Dieter Wolf
Varshavsky's contributions.
Science (New York, N.Y.) 2004;306(5700):1290-2.
2004: David L Boone; Emre E Turer; Eric G Lee; Regina-Celeste Ahmad; Matthew Wheeler; Colleen Tsui; Paula Hurley; Marcia Chien; Sophia Chai; Osamu Hitotsumatsu; Elizabeth McNally; Cecile M Pickart; Averil Ma
The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses.
Nature immunology 2004;5(10):1052-60.
2004: Shahri Raasi; Irina Orlov; Karen Fleming; Cecile M Pickart
Binding of polyubiquitin chains to ubiquitin-associated (UBA) domains of HHR23A.
Journal of molecular biology 2004;341(5):1367-79.
2004: Cecile M Pickart; Robert E Cohen
Proteasomes and their kin: proteases in the machine age.
Nature reviews. Molecular cell biology 2004;5(3):177-87.
2004: Ranjani Varadan; Michael Assfalg; Aydin Haririnia; Shahri Raasi; Cecile M Pickart; David Fushman
Solution conformation of Lys63-linked di-ubiquitin chain provides clues to functional diversity of polyubiquitin signaling.
The Journal of biological chemistry 2004;279(8):7055-63.
2004: Cecile M Pickart
Back to the future with ubiquitin.
Cell 2004;116(2):181-90.
2003: Pei-Ying Wu; Mary Hanlon; Michael J Eddins; Colleen Tsui; Richard S Rogers; Jane P Jensen; Michael J Matunis; Allan M Weissman; Allan M Weisman; Allan M Weissman; Cynthia Wolberger; Cynthia P Wolberger; Cecile M Pickart
A conserved catalytic residue in the ubiquitin-conjugating enzyme family.
The EMBO journal 2003;22(19):5241-50.
2003: Jianxin You; Min Wang; Tsutomu Aoki; Taka-aki Tamura; Cecile M Pickart
Proteolytic targeting of transcriptional regulator TIP120B by a HECT domain E3 ligase.
The Journal of biological chemistry 2003;278(26):23369-75.
2003: Mingsheng Zhang; Cecile M Pickart; Philip Coffino
Determinants of proteasome recognition of ornithine decarboxylase, a ubiquitin-independent substrate.
The EMBO journal 2003;22(7):1488-96.
2003: Shahri Raasi; Cecile M Pickart
Rad23 ubiquitin-associated domains (UBA) inhibit 26 S proteasome-catalyzed proteolysis by sequestering lysine 48-linked polyubiquitin chains.
The Journal of biological chemistry 2003;278(11):8951-9.
2002: Ranjani Varadan; Olivier WALKER; Cecile M Pickart; David Fushman
Structural properties of polyubiquitin chains in solution.
Journal of molecular biology 2002;324(4):637-47.
2002: Cecile M Pickart
DNA repair: right on target with ubiquitin.
Nature 2002;419(6903):120-1.
2002: Y Amy Lam; T Glen Lawson; Murugesan Velayutham; Jay L Zweier; Cecile M Pickart
A proteasomal ATPase subunit recognizes the polyubiquitin degradation signal.
Nature 2002;416(6882):763-7.
2001: Cecile M Pickart
Ubiquitin enters the new millennium.
Molecular cell 2001;8(3):499-504.
2001: K E Sloper-Mould; J C Jemc; Cecile M Pickart; Linda Hicke
Distinct functional surface regions on ubiquitin.
The Journal of biological chemistry 2001;276(32):30483-9.
2001: R M Hofmann; Cecile M Pickart
In vitro assembly and recognition of Lys-63 polyubiquitin chains.
The Journal of biological chemistry 2001;276(30):27936-43.
2001: Andrew P VanDemark; R M Hofmann; Colleen Tsui; Cecile M Pickart; Cynthia Wolberger
Molecular insights into polyubiquitin chain assembly: crystal structure of the Mms2/Ubc13 heterodimer.
Cell 2001;105(6):711-20.
2001: Jianxin You; Cecile M Pickart
A HECT domain E3 enzyme assembles novel polyubiquitin chains.
The Journal of biological chemistry 2001;276(23):19871-8.
2001: C L Phillips; JS Thrower; Cecile M Pickart; Christopher P Hill
Structure of a new crystal form of tetraubiquitin.
Acta crystallographica. Section D, Biological crystallography 2001;57(Pt 2):341-4.
2001: Cecile M Pickart
Mechanisms underlying ubiquitination.
Annual review of biochemistry 2001;70():503-33.
2000: Cecile M Pickart
Ubiquitin in chains.
Trends in biochemical sciences 2000;25(11):544-8.
2000: Cecile M Pickart; Andrew P VanDemark
Opening doors into the proteasome.
Nature structural biology 2000;7(11):999-1001.
2000: Li Deng; Chunfu Wang; E Spencer; L Yang; A Braun; J You; C Slaughter; Cecile M Pickart; Zhijian J Chen
Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain.
Cell 2000;103(2):351-61.
2000: A Argyrou; Michael W Washabaugh; Cecile M Pickart
Dihydroorotate dehydrogenase from Clostridium oroticum is a class 1B enzyme and utilizes a concerted mechanism of catalysis.
Biochemistry 2000;39(34):10373-84.
2000: Y Amy Lam; Cecile M Pickart; A Alban; M Landon; C Jamieson; Robert Ramage; R J Mayer; Robert Layfield
Inhibition of the ubiquitin-proteasome system in Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(18):9902-6.
2000: Cecile M Pickart
Ubiquitin biology: an old dog learns an old trick.
Nature cell biology 2000;2(8):E139-41.
2000: JS Thrower; Laura Hoffman; Martin Rechsteiner; Cecile M Pickart
Recognition of the polyubiquitin proteolytic signal.
The EMBO journal 2000;19(1):94-102.
1999: Jianxin You; Robert E Cohen; Cecile M Pickart
Construct for high-level expression and low misincorporation of lysine for arginine during expression of pET-encoded eukaryotic proteins in Escherichia coli.
BioTechniques 1999;27(5):950-4.
1999: L D Mastrandrea; J You; Edward G Niles; Cecile M Pickart
E2/E3-mediated assembly of lysine 29-linked polyubiquitin chains.
The Journal of biological chemistry 1999;274(38):27299-306.
1999: R M Hofmann; Cecile M Pickart
Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair.
Cell 1999;96(5):645-53.
1998: Frank G Whitby; G Xia; Cecile M Pickart; Christopher P Hill
Crystal structure of the human ubiquitin-like protein NEDD8 and interactions with ubiquitin pathway enzymes.
The Journal of biological chemistry 1998;273(52):34983-91.
1998: L D Mastrandrea; E M Kasperek; Edward G Niles; Cecile M Pickart
Core domain mutation (S86Y) selectively inactivates polyubiquitin chain synthesis catalyzed by E2-25K.
Biochemistry 1998;37(27):9784-92.
1998: P Young; Q Deveraux; RE Beal; Cecile M Pickart; Martin Rechsteiner
Characterization of two polyubiquitin binding sites in the 26 S protease subunit 5a.
The Journal of biological chemistry 1998;273(10):5461-7.
1998: RE Beal; D Toscano-Cantaffa; P Young; Martin Rechsteiner; Cecile M Pickart
The hydrophobic effect contributes to polyubiquitin chain recognition.
Biochemistry 1998;37(9):2925-34.
1997: Y Amy Lam; George N DeMartino; Cecile M Pickart; Robert E Cohen
Specificity of the ubiquitin isopeptidase in the PA700 regulatory complex of 26 S proteasomes.
The Journal of biological chemistry 1997;272(45):28438-46.
1997: Cecile M Pickart
Targeting of substrates to the 26S proteasome.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1997;11(13):1055-66.
1997: J Piotrowski; RE Beal; Laura Hoffman; Keith Wilkinson; Robert E Cohen; Cecile M Pickart
Inhibition of the 26 S proteasome by polyubiquitin chains synthesized to have defined lengths.
The Journal of biological chemistry 1997;272(38):23712-21.
1997: M T Haldeman; G Xia; E M Kasperek; Cecile M Pickart
Structure and function of ubiquitin conjugating enzyme E2-25K: the tail is a core-dependent activity element.
Biochemistry 1997;36(34):10526-37.
1996: M A Kalchman; Graham Kyrenia Rona; G Xia; H B Koide; J G Hodgson; K C Graham; Y Paul Goldberg; R Daniel Gietz; Cecile M Pickart; Michael R Hayden
Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme.
The Journal of biological chemistry 1996;271(32):19385-94.
1996: E S Berleth; Cecile M Pickart
Mechanism of ubiquitin conjugating enzyme E2-230K: catalysis involving a thiol relay?
Biochemistry 1996;35(5):1664-71.
1996: R Beal; Q Deveraux; G Xia; Martin Rechsteiner; Cecile M Pickart
Surface hydrophobic residues of multiubiquitin chains essential for proteolytic targeting.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(2):861-6.
1995: J Li; Cecile M Pickart
Binding of phenylarsenoxide to Arg-tRNA protein transferase is independent of vicinal thiols.
Biochemistry 1995;34(48):15829-37.
1995: Keith Wilkinson; V L Tashayev; L B O'Connor; C N Larsen; E Kasperek; Cecile M Pickart
Metabolism of the polyubiquitin degradation signal: structure, mechanism, and role of isopeptidase T.
Biochemistry 1995;34(44):14535-46.
1995: I Wefes; P Kaiser; R Schneider; Cecile M Pickart; Daniel Finley
Characterization of a cDNA clone encoding E2-20K, a murine ubiquitin-conjugating enzyme.
Gene 1995;163(2):321-2.
1995: I Wefes; L D Mastrandrea; M Haldeman; Stephen Thomas Koury; J Tamburlin; Cecile M Pickart; Daniel Finley
Induction of ubiquitin-conjugating enzymes during terminal erythroid differentiation.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(11):4982-6.
1995: M T Haldeman; Daniel Finley; Cecile M Pickart
Dynamics of ubiquitin conjugation during erythroid differentiation in vitro.
The Journal of biological chemistry 1995;270(16):9507-16.
1995: J Li; Cecile M Pickart
Inactivation of arginyl-tRNA protein transferase by a bifunctional arsenoxide: identification of residues proximal to the arsenoxide site.
Biochemistry 1995;34(1):139-47.
1994: Cecile M Pickart; E M Kasperek; R Beal; A Kim
Substrate properties of site-specific mutant ubiquitin protein (G76A) reveal unexpected mechanistic features of ubiquitin-activating enzyme (E1).
The Journal of biological chemistry 1994;269(10):7115-23.
1994: Q Deveraux; V Ustrell; Cecile M Pickart; Martin Rechsteiner
A 26 S protease subunit that binds ubiquitin conjugates.
The Journal of biological chemistry 1994;269(10):7059-61.
1994: William J Cook; L C Jeffrey; E Kasperek; Cecile M Pickart
Structure of tetraubiquitin shows how multiubiquitin chains can be formed.
Journal of molecular biology 1994;236(2):601-9.
1992: E S Berleth; J Li; J A Braunscheidel; Cecile M Pickart
A reactive nucleophile proximal to vicinal thiols is an evolutionarily conserved feature in the mechanism of Arg aminoacyl-tRNA protein transferase.
Archives of biochemistry and biophysics 1992;298(2):498-504.
1992: E S Berleth; E M Kasperek; S P Grill; J A Braunscheidel; L A Graziani; Cecile M Pickart
Inhibition of ubiquitin-protein ligase (E3) by mono- and bifunctional phenylarsenoxides. Evidence for essential vicinal thiols and a proximal nucleophile.
The Journal of biological chemistry 1992;267(23):16403-11.
1992: William J Cook; L C Jeffrey; M Carson; Zhijian J Chen; Cecile M Pickart
Structure of a diubiquitin conjugate and a model for interaction with ubiquitin conjugating enzyme (E2).
The Journal of biological chemistry 1992;267(23):16467-71.
1992: Cecile M Pickart; M T Haldeman; E M Kasperek; Zhijian J Chen
Iodination of tyrosine 59 of ubiquitin selectively blocks ubiquitin's acceptor activity in diubiquitin synthesis catalyzed by E2(25K).
The Journal of biological chemistry 1992;267(20):14418-23.
1991: Zhijian J Chen; E G Niles; Cecile M Pickart
Isolation of a cDNA encoding a mammalian multiubiquitinating enzyme (E225K) and overexpression of the functional enzyme in Escherichia coli.
The Journal of biological chemistry 1991;266(24):15698-704.
1991: P Sung; E Berleth; Cecile M Pickart; Satya Prakash; Louise Prakash
Yeast RAD6 encoded ubiquitin conjugating enzyme mediates protein degradation dependent on the N-end-recognizing E3 enzyme.
The EMBO journal 1991;10(8):2187-93.
1990: Zhijian J Chen; Cecile M Pickart
A 25-kilodalton ubiquitin carrier protein (E2) catalyzes multi-ubiquitin chain synthesis via lysine 48 of ubiquitin.
The Journal of biological chemistry 1990;265(35):21835-42.
1990: E S Berleth; Cecile M Pickart
Several mammalian ubiquitin carrier proteins, but not E2(20K), are related to the 20-kDa yeast E2, RAD6.
Biochemical and biophysical research communications 1990;171(2):705-10.
1989: N S Klemperer; Cecile M Pickart
Arsenite inhibits two steps in the ubiquitin-dependent proteolytic pathway.
The Journal of biological chemistry 1989;264(32):19245-52.
1989: N S Klemperer; E S Berleth; Cecile M Pickart
A novel, arsenite-sensitive E2 of the ubiquitin pathway: purification and properties.
Biochemistry 1989;28(14):6035-41.
1989: Cecile M Pickart; L A Graziani; S F Dosch
Murine erythroleukemia cells possess an active ubiquitin- and ATP-dependent proteolytic pathway.
Archives of biochemistry and biophysics 1989;272(1):114-21.
1988: Cecile M Pickart; A T Vella
Ubiquitin carrier protein-catalyzed ubiquitin transfer to histones. Mechanism and specificity.
The Journal of biological chemistry 1988;263(29):15076-82.
1988: Cecile M Pickart; A T Vella
Levels of active ubiquitin carrier proteins decline during erythroid maturation.
The Journal of biological chemistry 1988;263(24):12028-35.
1986: Cecile M Pickart; Irwin A Rose
Mechanism of ubiquitin carboxyl-terminal hydrolase. Borohydride and hydroxylamine inactivate in the presence of ubiquitin.
The Journal of biological chemistry 1986;261(22):10210-7.
1985: Cecile M Pickart; Irwin A Rose
Ubiquitin carboxyl-terminal hydrolase acts on ubiquitin carboxyl-terminal amides.
The Journal of biological chemistry 1985;260(13):7903-10.
1985: Cecile M Pickart; Irwin A Rose
Functional heterogeneity of ubiquitin carrier proteins.
The Journal of biological chemistry 1985;260(3):1573-81.
1985: Cecile M Pickart; Irwin A Rose
Functional heterogeneity of ubiquitin carrier proteins.
Progress in clinical and biological research 1985;180():215.
1984: Cecile M Pickart; W P Jencks
Energetics of the calcium-transporting ATPase.
The Journal of biological chemistry 1984;259(3):1629-43.
1982: Cecile M Pickart; W P Jencks
Slow dissociation of ATP from the calcium ATPase.
The Journal of biological chemistry 1982;257(10):5319-22.
1979: Cecile M Pickart; W P Jencks
Formation of stable anhydrides from CoA transferase and hydroxamic acids.
The Journal of biological chemistry 1979;254(18):9120-9.