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Peter Pickkers

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Tim Lubbers; Peter Pickkers; Jan Pompe; Bart P Ramakers; Jacco-Juri de Haan; Jan Willem Greve; Matthijs Kox; Wim A Buurman
Continuous administration of enteral lipid- and protein-rich nutrition limits inflammation in a human endotoxemia model.
Frank Schwoebel; Simone Sell; Lucas T van Eijk; Dirk Zboralski; Stefan Zöllner; Klaus Buchner; Dirk Eulberg; Martin Humphrey; Christian Maasch; Frank Morich; Peter Pickkers; Werner G Purschke; Sven Klussmann
The effects of the anti-hepcidin Spiegelmer NOX-H94 on inflammation-induced anemia in cynomolgus monkeys.
Matthijs Kox; M J W van den Berg; Johannes G van der Hoeven; A J van der Ven; J P M Wielders; Peter Pickkers
Vitamin D status is not associated with inflammatory cytokine levels during experimental human endotoxaemia.

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2013: Tim Lubbers; Peter Pickkers; Jan Pompe; Bart P Ramakers; Jacco-Juri de Haan; Jan Willem Greve; Matthijs Kox; Wim A Buurman
Continuous administration of enteral lipid- and protein-rich nutrition limits inflammation in a human endotoxemia model.
Critical care medicine 2013;41(5):1258-65.
2013: Frank Schwoebel; Simone Sell; Lucas T van Eijk; Dirk Zboralski; Stefan Zöllner; Klaus Buchner; Dirk Eulberg; Martin Humphrey; Christian Maasch; Frank Morich; Peter Pickkers; Werner G Purschke; Sven Klussmann
The effects of the anti-hepcidin Spiegelmer NOX-H94 on inflammation-induced anemia in cynomolgus monkeys.
Blood 2013;121(12):2311-5.
2013: Matthijs Kox; M J W van den Berg; Johannes G van der Hoeven; A J van der Ven; J P M Wielders; Peter Pickkers
Vitamin D status is not associated with inflammatory cytokine levels during experimental human endotoxaemia.
Clinical and experimental immunology 2013;171(2):231-6.
2013: Harmke D Kiers; Suzanne Heemskerk; Micha C J Schoenmakers; Mark van den Boogaard; Johannes G van der Hoeven; Henry A Van Swieten; Peter Pickkers
Comparison and clinical suitability of eight prediction models for cardiac surgery-related acute kidney injury.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2013;28(2):345-51.
2013: Hilde Pe Peters; Peter Pickkers; Dorine W Swinkels; Otto C Boerman; Elisabeth Am Cornelissen; Annemarie Eek; Coby Mm Laarakkers; Rosalinde Masereeuw; Jack Fm Wetzels
Tubular reabsorption and local production of urine hepcidin-25.
BMC nephrology 2013;14():70.
2013: Esther Peters; Johannes van der Hoeven; Andrea van Elsas; Jacques Arend; Suzanne Heemskerk; Luigi Jonk; Rosalinde Masereeuw; Peter Pickkers
Alkaline phosphatase as a treatment of sepsis-associated acute kidney injury.
The Journal of pharmacology and experimental therapeutics 2013;344(1):2-7.
2012: A van Berkel; J G van der Hoeven; Jan van Lieshout; J Hellegering; Peter Pickkers
Causes of death in intensive care patients with a low APACHE II score.
The Netherlands journal of medicine 2012;70(10):455-9.
2012: Frank van de Veerdonk; Jos W M van der Meer; Maria Mouktaroudi; Mihai G Netea; Peter Pickkers; Aikaterini Pistiki; Bart P Ramakers; Evangelos J Giamarellos-Bourboulis
Deficient Candida-specific T-helper 17 response during sepsis.
The Journal of infectious diseases 2012;206(11):1798-802.
2012: Jaap ten Oever; Mirjam Tromp; Chantal P Bleeker-Rovers; Leo A B Joosten; Mihai G Netea; Peter Pickkers; Frank L van de Veerdonk
Combination of biomarkers for the discrimination between bacterial and viral lower respiratory tract infections.
The Journal of infection 2012;65(6):490-5.
2012: Vera M Kamp; Jan-Willem J Lammers; Peter Pickkers; J Pillay; Laurien H Ulfman; Leo Koenderman
Human suppressive neutrophils CD16bright/CD62Ldim exhibit decreased adhesion.
Journal of leukocyte biology 2012;92(5):1011-20.
2012: Jenneke Leentjens; Mihai G Netea; Leo A B Joosten; Rebecca M Koch; Matthijs Kox; Frank Preijers; Johannes G van der Hoeven; Peter Pickkers
Reversal of immunoparalysis in humans in vivo: a double-blind, placebo-controlled, randomized pilot study.
American journal of respiratory and critical care medicine 2012;186(9):838-45.
2012: Bart P Ramakers; Niels P Riksen; Gerard A Rongen; Paul Smits; Petra H H van den Broek; Johannes G van der Hoeven; Kimberley E Wever; Matthijs Kox; Rosalinde Masereeuw; Faustin Mbuyi; Peter Pickkers
How systemic inflammation modulates adenosine metabolism and adenosine receptor expression in humans in vivo.
Critical care medicine 2012;40(9):2609-16.
2012: Mark van den Boogaard; Johannes G van der Hoeven; Lisette Schoonhoven; Theo van Achterberg; Peter Pickkers
Incidence and short-term consequences of delirium in critically ill patients: A prospective observational cohort study.
International journal of nursing studies 2012;49(7):775-83.
2012: Matthijs Kox; Mihai G Netea; Thijs M H Eijsvogels; Marc Gomes; Maria T E Hopman; Sanne P. Smeekens; Monique Stoffels; Nens van Alfen; Johannes G van der Hoeven; Peter Pickkers
The influence of concentration/meditation on autonomic nervous system activity and the innate immune response: a case study.
Psychosomatic medicine 2012;74(5):489-94.
2012: Miriam Moviat; Anniek M Terpstra; Johannes G van der Hoeven; Peter Pickkers
Impaired renal function is associated with greater urinary strong ion differences in critically ill patients with metabolic acidosis.
Journal of critical care 2012;27(3):255-60.
2012: Matthijs Kox; Peter Pickkers; Jan Pompe; Johannes G van der Hoeven; Maarten Q Vrouwenvelder; Cornelia W Hoedemaekers
The effects of brain injury on heart rate variability and the innate immune response in critically ill patients.
Journal of neurotrauma 2012;29(5):747-55.
2012: Frank M P van Haren; Mohamed Bahr; E Christiaan Boerma; Mary La Pine; Peter Pickkers; James Sleigh; Johannes G van der Hoeven
Hypertonic fluid administration in patients with septic shock: a prospective randomized controlled pilot study.
Shock (Augusta, Ga.) 2012;37(3):268-75.
2012: Jonne Doorduin; Leo M Heunks; Peter Pickkers
How can you mend a broken heart?.
Critical care medicine 2012;40(2):702-3.
2012: Tjaakje Visser; Luke P H Leenen; Peter Pickkers; J Pillay; Leo Koenderman
Homology in systemic neutrophil response induced by human experimental endotoxemia and by trauma.
Shock (Augusta, Ga.) 2012;37(2):145-51.
2012: Stan de Kleijn; Gerben Ferwerda; Peter W M Hermans; Martijn A Huijnen; Matthijs Kox; J Pillay; Iziah Edwin Sama; Johannes G van der Hoeven; Angela van Diepen; Peter Pickkers
Transcriptome kinetics of circulating neutrophils during human experimental endotoxemia.
PloS one 2012;7(6):e38255.
2012: Mirrin Josefien Dorresteijn; Peter Pickkers
Carboxyhemoglobin levels during human inflammation.
Critical care (London, England) 2012;16(2):24.
2012: Matthijs Kox; Gert Jan Scheffer; Johannes G van der Hoeven; Michiel Vaneker; Cornelia W Hoedemaekers; Peter Pickkers
Effects of vagus nerve stimulation and vagotomy on systemic and pulmonary inflammation in a two-hit model in rats.
PloS one 2012;7(4):e34431.
2012: Peter Pickkers; Jeroen Schouten; Herbert Spapen; albertus beishuizen; Michael Bulitta; Suzanne Heemskerk; Philippe G Jorens; Pierre-François Laterre; Wilbert H M Peters; Jean-Louis Vincent; Johannes G van der Hoeven
Alkaline phosphatase for treatment of sepsis-induced acute kidney injury: a prospective randomized double-blind placebo-controlled trial.
Critical care (London, England) 2012;16(1):R14.
2011: H D Kiers; R de Sévaux; Peter Pickkers
Cystatin C is not a reliable marker of residual glomerular filtration rate during continuous renal replacement therapy.
Intensive care medicine 2011;37(11):1893-4; author reply 1897-8.
2011: Håkan Hanberger; Marc Leone; Jeffrey Lipman; John C Marshall; Peter Pickkers; jordi rello; Yasser Sakr; Jean-Louis Vincent; Sten Walther; Antonio Anzueto; Philip S Barie; Milo Engoren; Peter Felleiter
Increased mortality associated with methicillin-resistant Staphylococcus aureus (MRSA) infection in the intensive care unit: results from the EPIC II study.
International journal of antimicrobial agents 2011;38(4):331-5.
2011: Bart P Ramakers; Niels P Riksen; Paul Smits; Johannes G van der Hoeven; Peter Pickkers
Modulation of innate immunity by adenosine receptor stimulation.
Shock (Augusta, Ga.) 2011;36(3):208-15.
2011: Matthijs Kox; Jan C Pompe; Johannes G van der Hoeven; Cornelia W Hoedemaekers; Peter Pickkers
Influence of different breathing patterns on heart rate variability indices and reproducibility during experimental endotoxaemia in human subjects.
Clinical science (London, England : 1979) 2011;121(5):215-22.
2011: Matthijs Kox; Mihai G Netea; Stan de Kleijn; Cornelia W Hoedemaekers; Jan Pompe; Bart P Ramakers; Johannes G van der Hoeven; Peter Pickkers
Differential ex vivo and in vivo endotoxin tolerance kinetics following human endotoxemia.
Critical care medicine 2011;39(8):1866-70.
2011: Matthijs Kox; Jan Pompe; Bart P Ramakers; Johannes G van der Hoeven; Cornelia W Hoedemaekers; Peter Pickkers
Interplay between the acute inflammatory response and heart rate variability in healthy human volunteers.
Shock (Augusta, Ga.) 2011;36(2):115-20.
2011: Matthijs Kox; Marije C Gordinou de Gouberville; Cornelia W Hoedemaekers; Jan Pompe; Johannes G van der Hoeven; Peter Pickkers
Effects of the α7 nicotinic acetylcholine receptor agonist GTS-21 on the innate immune response in humans.
Shock (Augusta, Ga.) 2011;36(1):5-11.
2011: M Tromp; M van den Boogaard; A R H van Zanten; C M Wallenborg; H S Biemond-Moeniralam; S E M Gielen-Wijffels; G J D Goekoop; D H T Tjan; Peter Pickkers
The effects of implementation of the Surviving Sepsis Campaign in the Netherlands.
The Netherlands journal of medicine 2011;69(6):292-8.
2011: Mark van den Boogaard; Johannes G van der Hoeven; Matthijs Kox; Kieran L Quinn; Lisette Schoonhoven; Theo van Achterberg; Peter Pickkers
Biomarkers associated with delirium in critically ill patients and their relation with long-term subjective cognitive dysfunction; indications for different pathways governing delirium in inflamed and noninflamed patients.
Critical care (London, England) 2011;15(6):R297.
2011: Bart P Ramakers; Niels P Riksen; Paul Smits; Thijmen H Stal; Petra van den Broek; Johannes G van der Hoeven; Suzanne Heemskerk; Wilbert H M Peters; Peter Pickkers
Dipyridamole augments the antiinflammatory response during human endotoxemia.
Critical care (London, England) 2011;15(6):R289.
2011: Frank Mp van Haren; Ray Cursons; Mary La Pine; Peter Pickkers; James Sleigh; Johannes G van der Hoeven
The effects of hypertonic fluid administration on the gene expression of inflammatory mediators in circulating leucocytes in patients with septic shock: a preliminary study.
Annals of intensive care 2011;1(1):44.
2011: Mark van den Boogaard; Rachel Pl van Swelm; Frans Gm Russel; Suzanne Heemskerk; Johannes G van der Hoeven; Rosalinde Masereeuw; Peter Pickkers
Urinary protein profiling in hyperactive delirium and non-delirium cardiac surgery ICU patients.
Proteome science 2011;9():13.
2011: Evangelos J Giamarellos-Bourboulis; Leo A B Joosten; Maria Mouktaroudi; Peter Pickkers; Maria Raftogiannis; Athina Savva; Frank van de Veerdonk; Jos W M van der Meer; Anastasia Antonopoulou; Marianna Georgitsi; Mihai G Netea
Inhibition of caspase-1 activation in Gram-negative sepsis and experimental endotoxemia.
Critical care (London, England) 2011;15(1):R27.
2011: Lucas T G J van Eijk; Joyce J C Kroot; Dorine W Swinkels; Mirjam Tromp; Johannes G van der Hoeven; Peter Pickkers
Inflammation-induced hepcidin-25 is associated with the development of anemia in septic patients: an observational study.
Critical care (London, England) 2011;15(1):R9.
2011: Bart P Ramakers; Niels P Riksen; Paul Smits; Petra van den Broek; Johannes G van der Hoeven; Barbara Franke; Wilbert H M Peters; Peter Pickkers
Circulating adenosine increases during human experimental endotoxemia but blockade of its receptor does not influence the immune response and subsequent organ injury.
Critical care (London, England) 2011;15(1):R3.
2011: Greetje van der Wal; Sylvia Brinkman; Laurens L A Bisschops; Cornelia W Hoedemaekers; Johannes G van der Hoeven; Dylan W de Lange; Nicolette F de Keizer; Peter Pickkers
Influence of mild therapeutic hypothermia after cardiac arrest on hospital mortality.
Critical care medicine 2011;39(1):84-8.
2010: H D Kiers; Donald E G Griesdale; Andrea Litchfield; Steven Reynolds; R T N Gibney; Dean Chittock; Peter Pickkers; David D Sweet
Effect of early achievement of physiologic resuscitation goals in septic patients admitted from the ward on the kidneys.
Journal of critical care 2010;25(4):563-9.
2010: Mirjam Tromp; Marlies E J L Hulscher; Chantal P Bleeker-Rovers; Lilian Peters; Daniëlle T N A van den Berg; George F Borm; Bart Jan Kullberg; Theo van Achterberg; Peter Pickkers
The role of nurses in the recognition and treatment of patients with sepsis in the emergency department: a prospective before-and-after intervention study.
International journal of nursing studies 2010;47(12):1464-73.
2010: Mirrin J Dorresteijn; Tjaakje Visser; Laura A E Cox; Martijn P Bouw; Janesh Pillay; Anky Koenderman; Paul F W Strengers; Luke P H Leenen; Johannes G van der Hoeven; Leo Koenderman; Peter Pickkers
C1-esterase inhibitor attenuates the inflammatory response during human endotoxemia.
Critical care medicine 2010;38(11):2139-45.
2010: Joyce J C Kroot; Coby M M Laarakkers; Anneke Geurts-Moespot; Nicolai Grebenchtchikov; Peter Pickkers; Annelies E van Ede; Hilde P E Peters; Edmée van Dongen-Lases; Jack F M Wetzels; Fred C G J Sweep; Harold Tjalsma; Dorine W Swinkels
Immunochemical and mass-spectrometry-based serum hepcidin assays for iron metabolism disorders.
Clinical chemistry 2010;56(10):1570-9.
2010: Mirrin J Dorresteijn; Annelies Draisma; Johannes G van der Hoeven; Peter Pickkers
Lipopolysaccharide-stimulated whole blood cytokine production does not predict the inflammatory response in human endotoxemia.
Innate immunity 2010;16(4):248-53.
2010: J Pillay; Bart P Ramakers; Vera M Kamp; Adele Lo Tam Loi; Siu W Lam; Falco Hietbrink; Loek P H Leenen; Anton T Tool; Peter Pickkers; Leo Koenderman
Functional heterogeneity and differential priming of circulating neutrophils in human experimental endotoxemia.
Journal of leukocyte biology 2010;88(1):211-20.
2010: Bart P Ramakers; Peter Pickkers
Adenosine-mediated attenuation of the innate immune response for only those who need it? The tailored potential of pentoxifylline.
Shock (Augusta, Ga.) 2010;34(1):105-6.
2010: Frank M P van Haren; Peter Pickkers; Norbert Foudraine; Suzanne Heemskerk; James Sleigh; Johannes G van der Hoeven
The effects of methylene blue infusion on gastric tonometry and intestinal fatty acid binding protein levels in septic shock patients.
Journal of critical care 2010;25(2):358.e1-7.
2010: Annelies Draisma; Mirrin J Dorresteijn; Martijn P W J M Bouw; Johannes G van der Hoeven; Peter Pickkers
The role of cytokines and inducible nitric oxide synthase in endotoxemia-induced endothelial dysfunction.
Journal of cardiovascular pharmacology 2010;55(6):595-600.
2010: Marloes M Ijland; Peter Pickkers
Do corticosteroids influence the granulocyte macrophage colony-stimulating factor-mediated effects on monocyte function?
American journal of respiratory and critical care medicine 2010;181(5):522; author reply 523.
2010: Cornelia Hoedemaekers; Marcel van Deuren; Tom Sprong; Peter Pickkers; Tom Eirik Mollnes; Ina Klasen; Johannes van der Hoeven
The complement system is activated in a biphasic pattern after coronary artery bypass grafting.
The Annals of thoracic surgery 2010;89(3):710-6.
2010: Jan T Groothuis; Gerard A Rongen; jaap deinum; Peter Pickkers; Alexander Hessel Jan Danser; Alexander C H Geurts; Paul Smits; Maria T E Hopman
Sympathetic nonadrenergic transmission contributes to autonomic dysreflexia in spinal cord-injured individuals.
Hypertension 2010;55(3):636-43.
2010: Koen S Simons; Peter Pickkers; Chantal P Bleeker-Rovers; Wim J G Oyen; Johannes G van der Hoeven
F-18-fluorodeoxyglucose positron emission tomography combined with CT in critically ill patients with suspected infection.
Intensive care medicine 2010;36(3):504-11.
2010: Ilma W F Fick; Myrthe M Tijdink; Feico J J Halbertsma; Johannes G van der Hoeven; Peter Pickkers
Risk factors for the deterioration of oxygenation ratio in ventilated intensive care unit patients: a retrospective cohort study.
Journal of critical care 2010;25(1):3-9.
2010: Feico J Halbertsma; Michiel Vaneker; Peter Pickkers; Chris Neeleman; Gert J Scheffer; Johannes G Hoeven van der
A single recruitment maneuver in ventilated critically ill children can translocate pulmonary cytokines into the circulation.
Journal of critical care 2010;25(1):10-5.
2010: Mark van den Boogaard; Sanne Ae Peters; Johannes G van der Hoeven; Pieter C Dagnelie; Pieter Leffers; Peter Pickkers; Lisette Schoonhoven
The impact of delirium on the prediction of in-hospital mortality in intensive care patients.
Critical care (London, England) 2010;14(4):R146.
2010: Irene P Jongerden; Anne Marie G A de Smet; Jan A J W Kluytmans; Leo F te Velde; Paul J Dennesen; Ronald M Wesselink; Martijn P Bouw; Rob Spanjersberg; Diana Bogaers-Hofman; Nardo J van der Meer; Jaap W de Vries; Karin Kaasjager; Mat van Iterson; Georg H Kluge; Tjip S van der Werf; Hubertus I Harinck; Alexander J Bindels; Peter Pickkers; Marc J Bonten
Physicians' and nurses' opinions on selective decontamination of the digestive tract and selective oropharyngeal decontamination: a survey.
Critical care (London, England) 2010;14(4):R132.
2010: Mark van den Boogaard; Bart P Ramakers; Nens van Alfen; Sieberen van der Werf; Wilhelmina F Fick; Cornelia W Hoedemaekers; Marcel M Verbeek; Lisette Schoonhoven; Johannes G van der Hoeven; Peter Pickkers
Endotoxemia-induced inflammation and the effect on the human brain.
Critical care (London, England) 2010;14(3):R81.
2010: Matthijs Kox; Peter Pickkers
Poison to the heart.
Critical care medicine 2010;38(1):331-2.
2009: Annelies Draisma; Moniek de Goeij; Constantijn W Wouters; Niels P Riksen; Wim J G Oyen; Gerard A Rongen; Otto Boerman; Marcel van Deuren; Johannes G van der Hoeven; Peter Pickkers
Endotoxin tolerance does not limit mild ischemia-reperfusion injury in humans in vivo.
Innate immunity 2009;15(6):360-7.
2009: Suzanne Heemskerk; Rosalinde Masereeuw; Frans G M Russel; Peter Pickkers
Selective iNOS inhibition for the treatment of sepsis-induced acute kidney injury.
Nature reviews. Nephrology 2009;5(11):629-40.
2009: M Tromp; Chantal P Bleeker-Rovers; T van Achterberg; T van Achterber; Bart Jan Kullberg; Marlies E J L Hulscher; Peter Pickkers
Internal medicine residents' knowledge about sepsis: effects of a teaching intervention.
The Netherlands journal of medicine 2009;67(9):312-5.
2009: Matthijs Kox; Jeroen F van Velzen; Jan C Pompe; Cornelia W Hoedemaekers; Johannes G van der Hoeven; Peter Pickkers
GTS-21 inhibits pro-inflammatory cytokine release independent of the Toll-like receptor stimulated via a transcriptional mechanism involving JAK2 activation.
Biochemical pharmacology 2009;78(7):863-72.
2009: Falco Hietbrink; Marc G H Besselink; Willem Renooij; Martin B M de Smet; Annelies Draisma; Hans van der Hoeven; Peter Pickkers
Systemic inflammation increases intestinal permeability during experimental human endotoxemia.
Shock (Augusta, Ga.) 2009;32(4):374-8.
2009: G Bosman; S M C Langemeijer; Konnie Hebeda; J M M Raemaekers; Peter Pickkers; W J F M van der Velden
The role of rituximab in a case of EBV-related lymphoproliferative disease presenting with haemophagocytosis.
The Netherlands journal of medicine 2009;67(8):364-5.
2009: Jan C Pompe; Matthijs Kox; Cornelia W Hoedemaekers; Johannes G van der Hoeven; Peter Pickkers
Nitric oxide inhalation and glucocorticoids as combined treatment in human experimental endotoxemia: It takes not always two to tango.
Critical care medicine 2009;37(9):2676; author reply 2676-7.
2009: Joachim Struck; Martina Strebelow; Sonja Tietz; Christine Alonso; Nils G. Morgenthaler; Johannes G van der Hoeven; Peter Pickkers; Andreas Bergmann
Method for the selective measurement of amino-terminal variants of procalcitonin.
Clinical chemistry 2009;55(9):1672-9.
2009: Marcel G A van der Heijden; Peter Pickkers; Geerten P van Nieuw Amerongen; Victor W M van Hinsbergh; Martijn P W J M Bouw; Johannes G van der Hoeven; A B Johan Groeneveld
Circulating angiopoietin-2 levels in the course of septic shock: relation with fluid balance, pulmonary dysfunction and mortality.
Intensive care medicine 2009;35(9):1567-74.
2009: W Joost Lesterhuis; Alexander J Rennings; William P Leenders; Arjan Nooteboom; Cornelis J Punt; Fred C Sweep; Peter Pickkers; Anneke Geurts-Moespot; Hanneke W Van Laarhoven; Johan Van der Vlag; Jo H Berden; Cor T Postma; Jos W Van der Meer
Vascular endothelial growth factor in systemic capillary leak syndrome.
The American journal of medicine 2009;122(6):e5-7.
2009: Feico J J Halbertsma; Michiel Vaneker; Peter Pickkers; Johannes G Hoeven
The oxygenation ratio during mechanical ventilation in children: the role of tidal volume and positive end-expiratory pressure.
Journal of critical care 2009;24(2):220-6.
2009: Annelies Draisma; Remy Bemelmans; Johannes G van der Hoeven; Peter Spronk; Peter Pickkers
Microcirculation and vascular reactivity during endotoxemia and endotoxin tolerance in humans.
Shock (Augusta, Ga.) 2009;31(6):581-5.
2009: Annelies Draisma; Peter Pickkers; Martijn P W J M Bouw; Johannes G van der Hoeven
Development of endotoxin tolerance in humans in vivo.
Critical care medicine 2009;37(4):1261-7.
2009: Peter Pickkers; F Snellen; P Rogiers; J Bakker; P Jorens; J Meulenbelt; H Spapen; J E Tulleken; R Lins; Steven Ramael; M Bulitta; Johannes G van der Hoeven
Clinical pharmacology of exogenously administered alkaline phosphatase.
European journal of clinical pharmacology 2009;65(4):393-402.
2009: M Hilkens; Peter Pickkers; W H M Peters; J G van der Hoeven
No elevation of glutathione S-transferase-a1-1 by amiodarone loading in intensive care unit patients with atrial fibrillation.
Anaesthesia and intensive care 2009;37(2):281-5.
2009: Suzanne Heemskerk; Rosalinde Masereeuw; Olof Moesker; Martijn P W J M Bouw; Johannes G van der Hoeven; Wilbert H M Peters; Frans G M Russel; Peter Pickkers
Alkaline phosphatase treatment improves renal function in severe sepsis or septic shock patients.
Critical care medicine 2009;37(2):417-23, e1.
2009: Bart P Ramakers; Moniek de Goeij; Johannes G van der Hoeven; Wilbert H M Peters; Peter Pickkers
Inflammation-induced hepatotoxicity in humans.
Shock (Augusta, Ga.) 2009;31(2):151-6.
2009: Mark van den Boogaard; Peter Pickkers; Hans van der Hoeven; Gabriel Roodbol; Theo van Achterberg; Lisette Schoonhoven
Implementation of a delirium assessment tool in the ICU can influence haloperidol use.
Critical care (London, England) 2009;13(4):R131.
2008: Feico J J Halbertsma; Michiel Vaneker; Peter Pickkers; Dirk G Snijdelaar; Jan van Egmond; Gert J Scheffer; Hans G van der Hoeven
Hypercapnic acidosis attenuates the pulmonary innate immune response in ventilated healthy mice.
Critical care medicine 2008;36(8):2403-6.
2008: Annelies Draisma; Mirrin J Dorresteijn; Peter Pickkers; Hans G van der Hoeven
The effect of systemic iNOS inhibition during human endotoxemia on the development of tolerance to different TLR-stimuli.
Innate immunity 2008;14(3):153-9.
2008: Erwin H J M Kemna; April E R Kartikasari; Lambertus J H Van Tits; Peter Pickkers; Harold Tjalsma; Dorine W Swinkels
Regulation of hepcidin: insights from biochemical analyses on human serum samples.
Blood cells, molecules & diseases 2008;40(3):339-46.
2008: Mirrin J Dorresteijn; Hans G van der Hoeven; Peter Pickkers
Volume therapy and innate immune response during systemic inflammation or sepsis.
Critical care medicine 2008;36(3):1028; author reply 1028-9.
2008: Miriam Moviat; Anniek M Terpstra; Wim Ruitenbeek; Leo A J Kluijtmans; Peter Pickkers; Johannes G van der Hoeven
Contribution of various metabolites to the "unmeasured" anions in critically ill patients with metabolic acidosis.
Critical care medicine 2008;36(3):752-8.
2008: Matthijs Kox; Jan Pompe; Peter Pickkers; C W Hoedemaekers; A B van Vugt; Johannes G van der Hoeven
Increased vagal tone accounts for the observed immune paralysis in patients with traumatic brain injury.
Neurology 2008;70(6):480-5.
2008: Suzanne Heemskerk; Frank M P van Haren; Norbert A Foudraine; Wilbert H M Peters; Johannes G van der Hoeven; Frans G M Russel; Rosalinde Masereeuw; Peter Pickkers
Short-term beneficial effects of methylene blue on kidney damage in septic shock patients.
Intensive care medicine 2008;34(2):350-4.
2008: Miriam A M Moviat; Peter Pickkers; Wim Ruitenbeek; Johannes G van der Hoeven
The nature of unmeasured anions in critically ill patients.
Critical care (London, England) 2008;12(2):416.
2007: F M P van Haren; J W Sleigh; Peter Pickkers; J G Van der Hoeven
Gastrointestinal perfusion in septic shock.
Anaesthesia and intensive care 2007;35(5):679-94.
2007: Matthijs Kox; Astrid W Hoedemaekers; Peter Pickkers; Johannes G van der Hoeven; Jan C Pompe
A possible role for the cholinergic anti-inflammatory pathway in increased mortality observed in critically ill patients receiving nicotine replacement therapy.
Critical care medicine 2007;35(10):2468-9; author reply 2469.
2007: Kurt J A Vanhoutte; Coby Laarakkers; Elena Marchiori; Peter Pickkers; Jack F M Wetzels; Johannes L Willems; Lambert P van den Heuvel; Frans G M Russel; Rosalinde Masereeuw
Biomarker discovery with SELDI-TOF MS in human urine associated with early renal injury: evaluation with computational analytical tools.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2007;22(10):2932-43.
2007: Suzanne Heemskerk; Rosalinde Masereeuw; Hans G van der Hoeven; Peter Pickkers
Renal effects of nitric oxide during sepsis: another two-edged sword?
American journal of respiratory and critical care medicine 2007;176(4):419-20; author reply 420.
2007: Matthijs Kox; Jan Pompe; Astrid Hoedemaekers; Peter Pickkers
Does subarachnoid haemorrhage affect the innate immune response?
Intensive care medicine 2007;33(7):1303; author reply 1304.
2007: Lucas T G J van Eijk; Mirrin J Dorresteijn; Paul Smits; Johannes G van der Hoeven; Mihai G Netea; Peter Pickkers
Gender differences in the innate immune response and vascular reactivity following the administration of endotoxin to human volunteers.
Critical care medicine 2007;35(6):1464-9.
2007: Jeroen Schouten; Alexander Bindels; Peter Pickkers; Hans G van der Hoeven
Cardiac surgery for infective endocarditis, complicated by septic cardioembolic stroke.
Stroke; a journal of cerebral circulation 2007;38(6):e31.
2007: Tom Sprong; Peter Pickkers; Anneke Geurts-Moespot; Johanna van der Ven-Jongekrijg; Chris Neeleman; Marlies Knaup; Didier Leroy; Thierry Calandra; Jos W M van der Meer; Fred C G J Sweep; Marcel van Deuren
Macrophage migration inhibitory factor (MIF) in meningococcal septic shock and experimental human endotoxemia.
Shock (Augusta, Ga.) 2007;27(5):482-7.
2007: Erik H de Laat; Lisette Schoonhoven; Mieke Grypdonck; André L M Verbeek; Ruurd de Graaf; Peter Pickkers; Theo van Achterberg
Early postoperative 30 degrees lateral positioning after coronary artery surgery: influence on cardiac output.
Journal of clinical nursing 2007;16(4):654-61.
2007: Erik H de Laat; Peter Pickkers; Lisette Schoonhoven; André L M Verbeek; Ton Feuth; Theo van Achterberg
Guideline implementation results in a decrease of pressure ulcer incidence in critically ill patients.
Critical care medicine 2007;35(3):815-20.
2007: Matthijs Kox; Sumangali Wijetunge; Peter Pickkers; Alun HUGHES
Inhibition of Src family tyrosine kinases prevents lipopolysaccharide-induced hyporeactivity in isolated rat tail arteries.
Vascular pharmacology 2007;46(3):195-200.
2007: M L H Cuijpers; Fidel J Vos; Chantal P Bleeker-Rovers; Paul Krabbe; Peter Pickkers; A P J van Dijk; Geert J A Wanten; P D J Sturm; Wim J G Oyen; Bart Jan Kullberg
Complicating infectious foci in patients with Staphylococcus aureus or Streptococcus species bacteraemia.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 2007;26(2):105-13.
2007: Dick H J Thijssen; Reinier Ellenkamp; Miriam Kooijman; Peter Pickkers; Gerard A Rongen; Maria T E Hopman; Paul Smits
A causal role for endothelin-1 in the vascular adaptation to skeletal muscle deconditioning in spinal cord injury.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(2):325-31.
2007: Erwin H J M Kemna; Peter Pickkers; Harold Tjalsma; Dorine W Swinkels
Nitric oxide does not contribute to inflammation-induced hypoferremia in humans.
Acta haematologica 2007;118(3):149-52.
2007: Wim van der Meer; Peter Pickkers; Colin Stephen Scott; Johannes G van der Hoeven; Jacqueline Klein Gunnewiek
Hematological indices, inflammatory markers and neutrophil CD64 expression: comparative trends during experimental human endotoxemia.
Journal of endotoxin research 2007;13(2):94-100.
2006: Bart P Ramakers; Niels P Riksen; Johannes G van der Hoeven; Paul Smits; Peter Pickkers
Protective effects of adenosine A2A agonist during hemorrhagic shock: a simple intervention may result in a complex response.
Critical care medicine 2006;34(12):3059; author reply 3059-60.
2006: Mirrin J Dorresteijn; Paul Smits; Hans G van der Hoeven; Peter Pickkers
Role of potassium channel blockade in the treatment of sepsis-induced vascular hyporeactivity.
Critical care medicine 2006;34(11):2867-8; author reply 2868-9.
2006: Peter Pickkers; Mirrin J Dorresteijn; Martijn P W J M Bouw; Johannes G van der Hoeven; Paul Smits
In vivo evidence for nitric oxide-mediated calcium-activated potassium-channel activation during human endotoxemia.
Circulation 2006;114(5):414-21.
2006: Suzanne Heemskerk; Peter Pickkers; Martijn P W J M Bouw; Annelies Draisma; Johannes G van der Hoeven; Wilbert H M Peters; Paul Smits; Frans G M Russel; Rosalinde Masereeuw
Upregulation of renal inducible nitric oxide synthase during human endotoxemia and sepsis is associated with proximal tubule injury.
Clinical journal of the American Society of Nephrology : CJASN 2006;1(4):853-62.
2006: Bart P Ramakers; Niels P Riksen; Gerard A Rongen; Johannes G van der Hoeven; Paul Smits; Peter Pickkers
The effect of adenosine receptor agonists on cytokine release by human mononuclear cells depends on the specific Toll-like receptor subtype used for stimulation.
Cytokine 2006;35(1-2):95-9.
2006: Erik H de Laat; Lisette Schoonhoven; Peter Pickkers; André L M Verbeek; Theo van Achterberg
Epidemiology, risk and prevention of pressure ulcers in critically ill patients: a literature review.
Journal of wound care 2006;15(6):269-75.
2006: Lucas T G J van Eijk; Arjan Nooteboom; Thijs Hendriks; Tom Sprong; Mihai G Netea; Paul Smits; Johannes G van der Hoeven; Peter Pickkers
Plasma obtained during human endotoxemia increases endothelial albumin permeability in vitro.
Shock (Augusta, Ga.) 2006;25(4):358-62.
2006: Erik H de Laat; Lisette Schoonhoven; Peter Pickkers; André L M Verbeek; Theo van Achterberg
Implementation of a new policy results in a decrease of pressure ulcer frequency.
International journal for quality in health care : journal of the International Society for Quality in Health Care / ISQua 2006;18(2):107-12.
2006: Miriam Moviat; Peter Pickkers; Peter H J van der Voort; Johannes G van der Hoeven
Acetazolamide-mediated decrease in strong ion difference accounts for the correction of metabolic alkalosis in critically ill patients.
Critical care (London, England) 2006;10(1):R14.
2005: Peter Pickkers; Tom Sprong; Lucas van Eijk; Hans van der Hoeven; Paul Smits; Marcel van Deuren
Vascular endothelial growth factor is increased during the first 48 hours of human septic shock and correlates with vascular permeability.
Shock (Augusta, Ga.) 2005;24(6):508-12.
2005: Mirrin J Dorresteijn; Peter Pickkers; Mihai G Netea; Johannes G van der Hoeven
IFN-gamma is not induced through increased plasma concentrations of interleukin-12/interleukin-18 during human endotoxemia.
European cytokine network 2005;16(3):191-3.
2005: Erwin H J M Kemna; Peter Pickkers; Elizabeta Nemeth; Hans G van der Hoeven; Dorine W Swinkels
Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS.
Blood 2005;106(5):1864-6.
2005: Jos J A Eijkenboom; Lucas T G J van Eijk; Peter Pickkers; Wilbert H M Peters; Jack F M Wetzels; Hans G van der Hoeven
Small increases in the urinary excretion of glutathione S-transferase A1 and P1 after cardiac surgery are not associated with clinically relevant renal injury.
Intensive care medicine 2005;31(5):664-7.
2005: Lucas T G J van Eijk; Peter Pickkers; Paul Smits; Wim van den Broek; Martijn P W J M Bouw; Johannes G van der Hoeven
Microvascular permeability during experimental human endotoxemia: an open intervention study.
Critical care (London, England) 2005;9(2):R157-64.
2005: Cornelia W Hoedemaekers; Peter Pickkers; Mihai G Netea; Marcel van Deuren; Johannes G van der Hoeven
Intensive insulin therapy does not alter the inflammatory response in patients undergoing coronary artery bypass grafting: a randomized controlled trial [ISRCTN95608630].
Critical care (London, England) 2005;9(6):R790-7.
2005: Mirrin J Dorresteijn; Lucas T G J van Eijk; Mihai G Netea; Paul Smits; Johannes G van der Hoeven; Peter Pickkers
Iso-osmolar prehydration shifts the cytokine response towards a more anti-inflammatory balance in human endotoxemia.
Journal of endotoxin research 2005;11(5):287-93.
2004: Lucas T G J van Eijk; Peter Pickkers; Paul Smits; Martijn P W J M Bouw; Johannes G van der Hoeven
Severe vagal response after endotoxin administration in humans.
Intensive care medicine 2004;30(12):2279-81.
2004: Peter Pickkers; Aarnout J Jansen Van Rosendaal; Johannes G van der Hoeven; Paul Smits
Activation of the ATP-dependent potassium channel attenuates norepinephrine-induced vasoconstriction in the human forearm.
Shock (Augusta, Ga.) 2004;22(4):320-5.
2004: Peter Pickkers; Astrid Hoedemaekers; Mihai G Netea; B E de Galan; Paul Smits; Johannes G van der Hoeven; Marcel van Deuren
Hypothesis: Normalisation of cytokine dysbalance explains the favourable effects of strict glucose regulation in the critically ill.
The Netherlands journal of medicine 2004;62(5):143-50.
2004: Bernard G Fikkers; Jacques A van Veen; Jan G M Kooloos; Peter Pickkers; Frank J A van den Hoogen; Berend Hillen; Johannes G van der Hoeven
Emphysema and pneumothorax after percutaneous tracheostomy: case reports and an anatomic study.
Chest 2004;125(5):1805-14.
2003: Peter Pickkers; Frans G M Russel; Theo Thien; Alun HUGHES; Paul Smits
Only weak vasorelaxant properties of loop diuretics in isolated resistance arteries from man, rat and guinea pig.
European journal of pharmacology 2003;466(3):281-7.
2003: Jan de Hoon; Peter Pickkers; Paul Smits; Harry A J Struijker Boudier; Luc M Van Bortel
Calcitonin gene-related peptide: exploring its vasodilating mechanism of action in humans.
Clinical pharmacology and therapeutics 2003;73(4):312-21.
2002: Peter Pickkers; Mihai G Netea; Jos W M van der Meer; Paul Smits
TNFalpha and IL-1beta exert no direct vasoactivity in human isolated resistance arteries.
Cytokine 2002;20(5):244-6.
2002: Evertine J Abbink; Peter Pickkers; A Jansen van Rosendaal; Jos A Lutterman; Cees J Tack; Frans G M Russel; Paul Smits
Vascular K(ATP) channel blockade by glibenclamide, but not by acarbose, in patients with Type II diabetes.
Clinical science (London, England : 1979) 2002;102(3):307-14.
2002: Evertine J Abbink; Peter Pickkers; A Jansen van Rosendaal; Jos A Lutterman; Cees J Tack; Frans G M Russel; Paul Smits
Vascular effects of glibenclamide vs. glimepiride and metformin in Type 2 diabetic patients.
Diabetic medicine : a journal of the British Diabetic Association 2002;19(2):136-43.
2001: Peter Pickkers; Alun HUGHES; Frans G M Russel; Theo Thien; Paul Smits
In vivo evidence for K(Ca) channel opening properties of acetazolamide in the human vasculature.
British journal of pharmacology 2001;132(2):443-50.
1999: Peter Pickkers; R S Garcha; M Schachter; Paul Smits; Alun HUGHES
Inhibition of carbonic anhydrase accounts for the direct vascular effects of hydrochlorothiazide.
Hypertension 1999;33(4):1043-8.
1998: Peter Pickkers; Alun HUGHES; Frans G M Russel; Theo Thien; Paul Smits
Thiazide-induced vasodilation in humans is mediated by potassium channel activation.
Hypertension 1998;32(6):1071-6.
1997: Peter Pickkers; TP Dormans; Frans G M Russel; Alun HUGHES; Theo Thien; N Schaper; Paul Smits
Direct vascular effects of furosemide in humans.
Circulation 1997;96(6):1847-52.
1996: T P Dormans; Peter Pickkers; F G Russel; Paul Smits
Vascular effects of loop diuretics.
Cardiovascular research 1996;32(6):988-97.
1996: Peter Pickkers; M Schachter; Alun HUGHES; M D Feher; Peter S Sever
Thiazide-induced hyperglycaemia: a role for calcium-activated potassium channels?
Diabetologia 1996;39(7):861-4.
1995: Peter Pickkers; Frans G M Russel; Alun HUGHES; Theo Thien; Paul Smits
Hydrochlorothiazide exerts no direct vasoactivity in the human forearm.
Journal of hypertension 1995;13(12 Pt 2):1833-6.
1995: Peter Pickkers; M Schachter; Peter S Sever; Alun HUGHES
Do KCa channels and carbonic anhydrase play a role in thiazide-induced hyperglycaemia?
Journal of human hypertension 1995;9(8):691-3.
1995: Peter Pickkers; Alun HUGHES
Relaxation and decrease in [Ca2+]i by hydrochlorothiazide in guinea-pig isolated mesenteric arteries.
British journal of pharmacology 1995;114(3):703-7.