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Raymond Pickles

Research Profile

Anatomy

Physiology

Virus Replication

Chemicals & Drugs

Devices

Gene Transfer Techniques

Living Beings

Disorders

Cystic Fibrosis

Concepts & Ideas

Molecular Sequence Data

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Publications

TOP 3
Mehmet Kesimer; K A Burns; C William Davis; Camille Ehre; John K Sheehan; Raymond J Pickles
Molecular organization of the mucins and glycocalyx underlying mucus transport over mucosal surfaces of the airways.
Anne Schaap-Nutt; Margaret A Scull; Emmalene J Bartlett; Peter L Collins; Rachael Liesman; Raymond J Pickles; Alexander C Schmidt
Human parainfluenza virus serotypes differ in their kinetics of replication and cytokine secretion in human tracheobronchial airway epithelium.
Camille Ehre; Barbara R Grubb; Rachael M Liesman; Wanda K O'Neal; Raymond J Pickles; Jean-Michel Sallenave; Erin N Worthington; Diane Barbier; Richard C Boucher
Overexpressing mouse model demonstrates the protective role of Muc5ac in the lungs.

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All Publications

2013: Mehmet Kesimer; K A Burns; C William Davis; Camille Ehre; John K Sheehan; Raymond J Pickles
Molecular organization of the mucins and glycocalyx underlying mucus transport over mucosal surfaces of the airways.
Mucosal immunology 2013;6(2):379-92.
2012: Anne Schaap-Nutt; Margaret A Scull; Emmalene J Bartlett; Peter L Collins; Rachael Liesman; Raymond J Pickles; Alexander C Schmidt
Human parainfluenza virus serotypes differ in their kinetics of replication and cytokine secretion in human tracheobronchial airway epithelium.
Virology 2012;433(2):320-8.
2012: Camille Ehre; Barbara R Grubb; Rachael M Liesman; Wanda K O'Neal; Raymond J Pickles; Jean-Michel Sallenave; Erin N Worthington; Diane Barbier; Richard C Boucher
Overexpressing mouse model demonstrates the protective role of Muc5ac in the lungs.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(41):16528-33.
2011: Liqun Zhang; Peter L Collins; Robert A Lamb; Raymond J Pickles
Comparison of differing cytopathic effects in human airway epithelium of parainfluenza virus 5 (W3A), parainfluenza virus type 3, and respiratory syncytial virus.
Virology 2011;421(1):67-77.
2011: Wuping Li; Raymond J Pickles; Zhijian Wu; Liqun Zhang; R Jude Samulski
AAV-6 mediated efficient transduction of mouse lower airways.
Virology 2011;417(2):327-33.
2011: Seiko F Okada; Raymond J Pickles; Liqun Zhang; Lubna H Abdullah; C William Davis; Silvia M Kreda; Eduardo R Lazarowski; Richard C Boucher
Coupled nucleotide and mucin hypersecretion from goblet-cell metaplastic human airway epithelium.
American journal of respiratory cell and molecular biology 2011;45(2):253-60.
2011: Irving C Allen; John B Bowzard; Beckley K Davis; Denis Gris; Yu Lei; Kathryn M Monroe; Chris B Moore; Raymond J Pickles; Priya Ranjan; Kelly E Roney; Suryaprakash Sambhara; Monika Schneider; Margaret A Scull; Albert G Zimmermann; Jenny P-Y Ting
NLRX1 protein attenuates inflammatory responses to infection by interfering with the RIG-I-MAVS and TRAF6-NF-κB signaling pathways.
Immunity 2011;34(6):854-65.
2011: Jarrod S Johnson; Martina Gentzsch; Liqun Zhang; Carla M P Ribeiro; Boris Kantor; Tal Kafri; Raymond J Pickles; R Jude Samulski
AAV exploits subcellular stress associated with inflammation, endoplasmic reticulum expansion, and misfolded proteins in models of cystic fibrosis.
PLoS pathogens 2011;7(5):e1002053.
2011: Neeltje van Doremalen; Ian M Jones; Raymond J Pickles; Kim L Roberts; Holly Shelton; Catherine I Thompson; Wendy S Barclay
A single amino acid in the HA of pH1N1 2009 influenza virus affects cell tropism in human airway epithelium, but not transmission in ferrets.
PloS one 2011;6(10):e25755.
2010: Liqun Zhang; Maria P Limberis; Catherine Thompson; Marcelo B Antunes; Cindy Luongo; James M Wilson; Peter L Collins; Raymond J Pickles
α-Fetoprotein gene delivery to the nasal epithelium of nonhuman primates by human parainfluenza viral vectors.
Human gene therapy 2010;21(12):1657-64.
2010: Krzysztof Pyrc; Amy C Sims; Ronald Dijkman; Maarten Jebbink; Casey Long; Damon Deming; Eric Donaldson; Astrid Vabret; Ralph S Baric; Lia van der Hoek; Raymond J Pickles
Culturing the unculturable: human coronavirus HKU1 infects, replicates, and produces progeny virions in human ciliated airway epithelial cell cultures.
Journal of virology 2010;84(21):11255-63.
2010: Joshua C Eby; William P Ciesla; Wendy Hamman; Gina M Donato; Raymond J Pickles; Erik L Hewlett; Wayne I Lencer
Selective translocation of the Bordetella pertussis adenylate cyclase toxin across the basolateral membranes of polarized epithelial cells.
The Journal of biological chemistry 2010;285(14):10662-70.
2010: Anne Schaap-Nutt; Margaret A Scull; Alexander C Schmidt; Brian R Murphy; Raymond J Pickles
Growth restriction of an experimental live attenuated human parainfluenza virus type 2 vaccine in human ciliated airway epithelium in vitro parallels attenuation in African green monkeys.
Vaccine 2010;28(15):2788-98.
2010: Anne Schaap-Nutt; Christopher D'Angelo; Margaret A Scull; Emerito Amaro-Carambot; Machiko Nishio; Raymond J Pickles; Peter L Collins; Brian R Murphy; Alexander C Schmidt
Human parainfluenza virus type 2 V protein inhibits interferon production and signaling and is required for replication in non-human primates.
Virology 2010;397(2):285-98.
2009: Wuping Li; Liqun Zhang; Jarrod S Johnson; Wu Zhijian; Joshua C Grieger; Xiao Ping-Jie; Lauren M Drouin; Mavis Agbandje-McKenna; Raymond J Pickles; R Jude Samulski
Generation of novel AAV variants by directed evolution for improved CFTR delivery to human ciliated airway epithelium.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(12):2067-77.
2009: Steven Kwilas; Rachael M Liesman; Liqun Zhang; Edward Walsh; Raymond J Pickles; Mark Peeples
Respiratory syncytial virus grown in Vero cells contains a truncated attachment protein that alters its infectivity and dependence on glycosaminoglycans.
Journal of virology 2009;83(20):10710-8.
2009: Liqun Zhang; Brian Button; Sherif E Gabriel; Susan Burkett; Yu Yan; Mario Skiadopoulos; Yan Li Dang; Leatrice N Vogel; Tristan McKay; April Mengos; Richard C Boucher; Peter L Collins; Raymond J Pickles
CFTR delivery to 25% of surface epithelial cells restores normal rates of mucus transport to human cystic fibrosis airway epithelium.
PLoS biology 2009;7(7):e1000155.
2009: Mehmet Kesimer; Margaret Scull; Brian Brighton; Genevieve DeMaria; Kimberlie Burns; Wanda O Neal; Raymond J Pickles; John K Sheehan
Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(6):1858-68.
2009: Margaret A Scull; Laura Gillim-Ross; Celia Santos; Kim L Roberts; Elena Bordonali; Kanta Subbarao; Wendy S Barclay; Raymond J Pickles
Avian Influenza virus glycoproteins restrict virus replication and spread through human airway epithelium at temperatures of the proximal airways.
PLoS pathogens 2009;5(5):e1000424.
2009: Irving Allen; Margaret A Scull; Chris B Moore; Eda K Holl; Erin McElvania-Tekippe; Debra J Taxman; Elizabeth H Guthrie; Raymond J Pickles; Jenny P-Y Ting
The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA.
Immunity 2009;30(4):556-65.
2009: Maria P Limberis; Luk Vandenberghe; Liqun Zhang; Raymond J Pickles; James M Wilson
Transduction efficiencies of novel AAV vectors in mouse airway epithelium in vivo and human ciliated airway epithelium in vitro.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(2):294-301.
2009: Alexander Bukreyev; Andrea Marzi; Friederike Feldmann; Liqun Zhang; Lijuan Yang; Jerrold M Ward; David W Dorward; Raymond J Pickles; Brian Murphy; Heinz Feldmann; Peter L Collins
Chimeric human parainfluenza virus bearing the Ebola virus glycoprotein as the sole surface protein is immunogenic and highly protective against Ebola virus challenge.
Virology 2009;383(2):348-61.
2009: Guadalupe Ayora-Talavera; Holly Shelton; Margaret A Scull; Junyuan Ren; Ian M Jones; Raymond J Pickles; Wendy S Barclay
Mutations in H5N1 influenza virus hemagglutinin that confer binding to human tracheal airway epithelium.
PloS one 2009;4(11):e7836.
2009: Yu Lei; Chris B Moore; Rachael M Liesman; Brian P O'Connor; Daniel T Bergstralh; Zhijian J Chen; Raymond J Pickles; Jenny P-Y Ting
MAVS-mediated apoptosis and its inhibition by viral proteins.
PloS one 2009;4(5):e5466.
2009: Mehmet Kesimer; Sara Kirkham; Raymond J Pickles; Ashley Henderson; Neil E Alexis; Genevieve Demaria; David Knight; David J Thornton; John K Sheehan
Tracheobronchial air-liquid interface cell culture: a model for innate mucosal defense of the upper airways?
American journal of physiology. Lung cellular and molecular physiology 2009;296(1):L92-L100.
2008: Michelle M Becker; Rachel L Graham; Eric Donaldson; Barry Rockx; Amy C Sims; Timothy Sheahan; Raymond J Pickles; Davide Corti; Robert E Johnston; Ralph S Baric; Mark Denison
Synthetic recombinant bat SARS-like coronavirus is infectious in cultured cells and in mice.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(50):19944-9.
2008: Eric Donaldson; Boyd Yount; Amy C Sims; Susan Burkett; Raymond J Pickles; Ralph S Baric
Systematic assembly of a full-length infectious clone of human coronavirus NL63.
Journal of virology 2008;82(23):11948-57.
2008: Emmalene J Bartlett; Ann-Marie Cruz; Janice Esker; Adam Castaño; Henrick Schomacker; Sonja R Surman; Margaret Hennessey; Jim Boonyaratanakornkit; Raymond J Pickles; Peter L Collins; Brian Murphy; Alexander C Schmidt
Human parainfluenza virus type 1 C proteins are nonessential proteins that inhibit the host interferon and apoptotic responses and are required for efficient replication in nonhuman primates.
Journal of virology 2008;82(18):8965-77.
2008: Emmalene J Bartlett; Margaret Hennessey; Mario Skiadopoulos; Alexander C Schmidt; Peter L Collins; Brian Murphy; Raymond J Pickles
Role of interferon in the replication of human parainfluenza virus type 1 wild type and mutant viruses in human ciliated airway epithelium.
Journal of virology 2008;82(16):8059-70.
2008: Amy C Sims; Susan E Burkett; Boyd Yount; Raymond J Pickles
SARS-CoV replication and pathogenesis in an in vitro model of the human conducting airway epithelium.
Virus research 2008;133(1):33-44.
2008: Timothy Sheahan; Barry Rockx; Eric Donaldson; Amy C Sims; Raymond J Pickles; Davide Corti; Ralph S Baric
Mechanisms of zoonotic severe acute respiratory syndrome coronavirus host range expansion in human airway epithelium.
Journal of virology 2008;82(5):2274-85.
2007: Joanna Chapman; Elizabeth Abbott; Dagmar G Alber; Robert C Baxter; Sian K Bithell; Elisa A Henderson; Malcolm C Carter; Phil Chambers; Ann Chubb; G Stuart Cockerill; Peter L Collins; Verity C L Dowdell; Sally J Keegan; Richard D Kelsey; Michael J Lockyer; Cindy Luongo; Pilar Najarro; Raymond J Pickles; Mark Simmonds; Debbie Taylor; Stan Tyms; Lara J Wilson; Kenneth L Powell
RSV604, a novel inhibitor of respiratory syncytial virus replication.
Antimicrobial agents and chemotherapy 2007;51(9):3346-53.
2007: Barry Rockx; Timothy Sheahan; Eric Donaldson; Jack R Harkema; Amy C Sims; Mark T Heise; Raymond J Pickles; Mark Cameron; David Kelvin; Ralph S Baric
Synthetic reconstruction of zoonotic and early human severe acute respiratory syndrome coronavirus isolates that produce fatal disease in aged mice.
Journal of virology 2007;81(14):7410-23.
2007: Joshua D Hall; Robin R Craven; James R Fuller; Raymond J Pickles; Thomas H Kawula
Francisella tularensis replicates within alveolar type II epithelial cells in vitro and in vivo following inhalation.
Infection and immunity 2007;75(2):1034-9.
2006: Damon Deming; Timothy Sheahan; Mark T Heise; Boyd Yount; Nancy L Davis; Amy C Sims; Mehul Suthar; Jack R Harkema; Alan C Whitmore; Raymond J Pickles; Ande West; Eric Donaldson; Kris Curtis; Robert Johnston; Ralph S Baric
Vaccine efficacy in senescent mice challenged with recombinant SARS-CoV bearing epidemic and zoonotic spike variants.
PLoS medicine 2006;3(12):e525.
2006: Catherine I Thompson; Wendy S Barclay; Maria C Zambon; Raymond J Pickles
Infection of human airway epithelium by human and avian strains of influenza a virus.
Journal of virology 2006;80(16):8060-8.
2006: T McKay; M Patel; Raymond J Pickles; Larry G Johnson; John C Olsen
Influenza M2 envelope protein augments avian influenza hemagglutinin pseudotyping of lentiviral vectors.
Gene therapy 2006;13(8):715-24.
2006: John K Sheehan; Mehmet Kesimer; Raymond J Pickles
Innate immunity and mucus structure and function.
Novartis Foundation symposium 2006;279():155-66; discussion 167-9, 216-9.
2006: Timothy Sheahan; Damon Deming; Eric Donaldson; Raymond J Pickles; Ralph S Baric
Resurrection of an "extinct" SARS-CoV isolate GD03 from late 2003.
Advances in experimental medicine and biology 2006;581():547-50.
2006: Amy C Sims; Boyd Yount; Susan E Burkett; Ralph S Baric; Raymond J Pickles
SARS CoV replication and pathogenesis in human airway epithelial cultures.
Advances in experimental medicine and biology 2006;581():535-8.
2005: Amy C Sims; Ralph S Baric; Boyd Yount; Susan E Burkett; Peter L Collins; Raymond J Pickles
Severe acute respiratory syndrome coronavirus infection of human ciliated airway epithelia: role of ciliated cells in viral spread in the conducting airways of the lungs.
Journal of virology 2005;79(24):15511-24.
2005: Robert Tarran; Brian Button; Maryse Picher; Anthony M Paradiso; Carla M Pedrosa Ribeiro; Eduardo R Lazarowski; Liqun Zhang; Peter L Collins; Raymond J Pickles; Jeffrey J Fredberg; Richard C Boucher
Normal and cystic fibrosis airway surface liquid homeostasis. The effects of phasic shear stress and viral infections.
The Journal of biological chemistry 2005;280(42):35751-9.
2005: Subinoy Das; Owen P Palmer; W Derek Leight; Joshua B Surowitz; Raymond J Pickles; Scott H Randell; Craig A Buchman
Cytokine amplification by respiratory syncytial virus infection in human nasal epithelial cells.
The Laryngoscope 2005;115(5):764-8.
2005: Liqun Zhang; Alexander Bukreyev; Catherine I Thompson; Brandy Watson; Mark Peeples; Peter L Collins; Raymond J Pickles
Infection of ciliated cells by human parainfluenza virus type 3 in an in vitro model of human airway epithelium.
Journal of virology 2005;79(2):1113-24.
2004: Jaclyn R Stonebraker; Danielle Wagner; Robert W Lefensty; Kimberlie Burns; Sandra J Gendler; Jeffrey M Bergelson; Richard C Boucher; Wanda O Neal; Raymond J Pickles
Glycocalyx restricts adenoviral vector access to apical receptors expressed on respiratory epithelium in vitro and in vivo: role for tethered mucins as barriers to lumenal infection.
Journal of virology 2004;78(24):13755-68.
2004: Raymond J Pickles
Physical and biological barriers to viral vector-mediated delivery of genes to the airway epithelium.
Proceedings of the American Thoracic Society 2004;1(4):302-8.
2004: Thomas E Mellow; Paula C Murphy; Johnny L Carson; Terry L Noah; Liqun Zhang; Raymond J Pickles
The effect of respiratory synctial virus on chemokine release by differentiated airway epithelium.
Experimental lung research 2004;30(1):43-57.
2002: Liqun Zhang; Mark Peeples; Richard C Boucher; Peter L Collins; Raymond J Pickles
Respiratory syncytial virus infection of human airway epithelial cells is polarized, specific to ciliated cells, and without obvious cytopathology.
Journal of virology 2002;76(11):5654-66.
2001: Christopher J Cohen; Joseph T C Shieh; Raymond J Pickles; Takatsugu Okegawa; J T Hsieh; Jeffrey M Bergelson
The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(26):15191-6.
2001: Bruce F Israel; Raymond J Pickles; D M Segal; R D Gerard; Shannon C Kenney
Enhancement of adenovirus vector entry into CD70-positive B-cell Lines by using a bispecific CD70-adenovirus fiber antibody.
Journal of virology 2001;75(11):5215-21.
2000: ME Hutchin; Raymond J Pickles; Wendell G Yarbrough
Efficiency of adenovirus-mediated gene transfer to oropharyngeal epithelial cells correlates with cellular differentiation and human coxsackie and adenovirus receptor expression.
Human gene therapy 2000;11(17):2365-75.
2000: Raymond J Pickles; J A Fahrner; JenniElizabeth Petrella; Richard C Boucher; Jeffrey M Bergelson
Retargeting the coxsackievirus and adenovirus receptor to the apical surface of polarized epithelial cells reveals the glycocalyx as a barrier to adenovirus-mediated gene transfer.
Journal of virology 2000;74(13):6050-7.
2000: Silvia M Kreda; Raymond J Pickles; Eduardo R Lazarowski; Richard C Boucher
G-protein-coupled receptors as targets for gene transfer vectors using natural small-molecule ligands.
Nature biotechnology 2000;18(6):635-40.
1998: Raymond J Pickles; Douglass Mccarty; Hirotoshi Matsui; P J Hart; Scott H Randell; Richard C Boucher
Limited entry of adenovirus vectors into well-differentiated airway epithelium is responsible for inefficient gene transfer.
Journal of virology 1998;72(7):6014-23.
1998: RK Batra; John C Olsen; Raymond J Pickles; DK Hoganson; Richard C Boucher
Transduction of non-small cell lung cancer cells by adenoviral and retroviral vectors.
American journal of respiratory cell and molecular biology 1998;18(3):402-10.
1997: Raymond J Pickles
Towards a gene therapy for cystic fibrosis lung disease.
Expert opinion on investigational drugs 1997;6(10):1459-63.
1997: Giovanni Piedimonte; Raymond J Pickles; J R Lehmann; Douglass Mccarty; Daniel L Costa; Richard C Boucher
Replication-deficient adenoviral vector for gene transfer potentiates airway neurogenic inflammation.
American journal of respiratory cell and molecular biology 1997;16(3):250-8.
1996: Raymond J Pickles; Pierre M Barker; H Ye; Richard C Boucher
Efficient adenovirus-mediated gene transfer to basal but not columnar cells of cartilaginous airway epithelia.
Human gene therapy 1996;7(8):921-31.
1996: Larry G Johnson; Raymond J Pickles; S E Boyles; J C Morris; H Ye; Z Zhou; John C Olsen; Richard C Boucher
In vitro assessment of variables affecting the efficiency and efficacy of adenovirus-mediated gene transfer to cystic fibrosis airway epithelia.
Human gene therapy 1996;7(1):51-9.
1994: Barbara R Grubb; Raymond J Pickles; H Ye; James R Yankaskas; R N Vick; J F Engelhardt; J M Wilson; Larry G Johnson; Richard C Boucher
Inefficient gene transfer by adenovirus vector to cystic fibrosis airway epithelia of mice and humans.
Nature 1994;371(6500):802-6.
1994: Richard C Boucher; Michael Knowles; Larry G Johnson; John C Olsen; Raymond J Pickles; J M Wilson; J Engelhardt; Y Yang; M Grossman
Gene therapy for cystic fibrosis using E1-deleted adenovirus: a phase I trial in the nasal cavity. The University of North Carolina at Chapel Hill.
Human gene therapy 1994;5(5):615-39.
1993: Lesley MacVinish; Raymond J Pickles; Alan W Cuthbert
Cyclic AMP and Ca2+ interactions affecting epithelial chloride secretion in human cultured colonic epithelia.
British journal of pharmacology 1993;108(2):462-8.
1992: Alan W Cuthbert; Lesley MacVinish; Raymond J Pickles
Antagonism of kinin effects on epithelial by Hoe 140: apparently competitive and non-competitive interactions.
British journal of pharmacology 1992;107(3):797-802.
1992: Raymond J Pickles; Alan W Cuthbert
Failure of thapsigargin to alter ion transport in human sweat gland epithelia while intracellular Ca2+ concentration is raised.
The Journal of biological chemistry 1992;267(21):14818-25.
1991: M Roberts; Stephen B Hladky; Raymond J Pickles; Alan W Cuthbert
Stimulation of sodium transport by duramycin in cultured human colonic epithelia.
The Journal of pharmacology and experimental therapeutics 1991;259(3):1050-8.
1991: Raymond J Pickles; D J Brayden; Alan W Cuthbert
Synchronous transporting activity in epithelial cells in relation to intracellular calcium concentration.
Proceedings. Biological sciences / The Royal Society 1991;245(1312):53-8.
1991: Raymond J Pickles; Alan W Cuthbert
Relation of anion secretory activity to intracellular Ca2+ in response to lysylbradykinin and histamine in a cultured human colonic epithelium.
European journal of pharmacology 1991;199(1):77-91.
1991: D J Brayden; Raymond J Pickles; Alan W Cuthbert
Ion transport in cultured epithelia from human sweat glands: comparison of normal and cystic fibrosis tissues.
British journal of pharmacology 1991;102(1):57-64.