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Silvia Pierangeli

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Rohan Willis; Silvia S Pierangeli
Anti-β2 -glycoprotein I antibodies.
Al Carrera-Marín; Ethel García-Latorre; E Papalardo; Elba Reyes Maldonado; Zurina Romay-Penabad; T Shilagard; G Vargas; Silvia S Pierangeli
C6 knock-out mice are protected from thrombophilia mediated by antiphospholipid antibodies.
Rohan Willis; E Nigel Harris; Silvia S Pierangeli
Current international initiatives in antiphospholipid antibody testing.

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All Publications

2013: Rohan Willis; Silvia S Pierangeli
Anti-β2 -glycoprotein I antibodies.
Annals of the New York Academy of Sciences 2013;1285(1):44-58.
2012: Al Carrera-Marín; Ethel García-Latorre; E Papalardo; Elba Reyes Maldonado; Zurina Romay-Penabad; T Shilagard; G Vargas; Silvia S Pierangeli
C6 knock-out mice are protected from thrombophilia mediated by antiphospholipid antibodies.
Lupus 2012;21(14):1497-505.
2012: Rohan Willis; E Nigel Harris; Silvia S Pierangeli
Current international initiatives in antiphospholipid antibody testing.
Seminars in thrombosis and hemostasis 2012;38(4):360-74.
2012: Rohan Willis; E Nigel Harris; Silvia S Pierangeli
Pathogenesis of the antiphospholipid syndrome.
Seminars in thrombosis and hemostasis 2012;38(4):305-21.
2012: Silvia S Pierangeli; Angela Tincani; Richard C W Wong; Emmanuel J Favaloro; Gabriella Lakos; Pier Luigi Meroni; E Nigel Harris
Standards and reference materials for the anticardiolipin and anti-β2glycoprotein I assays: a report of recommendations from the APL Task Force at the 13th International Congress on Antiphospholipid Antibodies.
Clinica chimica acta; international journal of clinical chemistry 2012;413(1-2):358-60.
2011: Silvia S Pierangeli; Benjamin Leader; Giuseppe Barilaro; Rohan Willis; D Ware Branch
Acquired and inherited thrombophilia disorders in pregnancy.
Obstetrics and gynecology clinics of North America 2011;38(2):271-95, x.
2011: Silvia S Pierangeli; P G de Groot; J Dlott; E Favaloro; E Nigel Harris; G Lakos; T Ortel; Pier Luigi Meroni; K Otomo; V Pengo; Angela Tincani; R Wong; R Roubey
'Criteria' aPL tests: report of a task force and preconference workshop at the 13th International Congress on Antiphospholipid Antibodies, Galveston, Texas, April 2010.
Lupus 2011;20(2):182-90.
2011: Zurina Romay-Penabad; Renan Aguilar-Valenzuela; Rolf T Urbanus; R H W M Derksen; Maarten T T Pennings; Elizabeth Papalardo; Tuya Shilagard; Gracie Vargas; Yong Hwang; Philip G de Groot; Silvia S Pierangeli
Apolipoprotein E receptor 2 is involved in the thrombotic complications in a murine model of the antiphospholipid syndrome.
Blood 2011;117(4):1408-14.
2009: Zurina Romay-Penabad; Maria Guadalupe Montiel-Manzano; Tuya Shilagard; Elizabeth Papalardo; Gracie Vargas; Arun B Deora; Michael Wang; Andrew T Jacovina; Ethel Garcia-Latorre; Elba Reyes Maldonado; Katherine A Hajjar; Silvia S Pierangeli
Annexin A2 is involved in antiphospholipid antibody-mediated pathogenic effects in vitro and in vivo.
Blood 2009;114(14):3074-83.
2009: Praveen Jajoria; Vijaya Murthy; Elizabeth Papalardo; Zurina Romay-Penabad; Caroline Gleason; Silvia S Pierangeli
Statins for the treatment of antiphospholipid syndrome?
Annals of the New York Academy of Sciences 2009;1173():736-45.
2009: Iván Palomo; F Segovia; C Ortega; Silvia S Pierangeli
Antiphospholipid syndrome: a comprehensive review of a complex and multisystemic disease.
Clinical and experimental rheumatology 2009;27(4):668-77.
2008: Silvia S Pierangeli; E Nigel Harris
A quarter of a century in anticardiolipin antibody testing and attempted standardization has led us to here, which is?
Seminars in thrombosis and hemostasis 2008;34(4):313-28.
2008: Silvia S Pierangeli; Pojen P Chen; Elena Raschi; Silvia Scurati; Carlo E Grossi; Maria Orietta Borghi; Ivan Palomo; E Nigel Harris; Pier Luigi Meroni
Antiphospholipid antibodies and the antiphospholipid syndrome: pathogenic mechanisms.
Seminars in thrombosis and hemostasis 2008;34(3):236-50.
2008: Silvia S Pierangeli
Novel therapies for the antiphospholipid syndrome.
Expert review of clinical immunology 2008;4(2):193-203.
2008: Silvia S Pierangeli; Eon Nigel Harris
A protocol for determination of anticardiolipin antibodies by ELISA.
Nature protocols 2008;3(5):840-8.
2007: Jodi K Sebastian; Barbara Voetsch; John H Stone; Zurina Romay-Penabad; Grace H Lo; Nancy B Allen; John C Davis; Gary S Hoffman; W Joseph McCune; E William St Clair; Ulrich Specks; Robert Spiera; Joseph Loscalzo; Silvia S Pierangeli; Peter A Merkel
The frequency of anticardiolipin antibodies and genetic mutations associated with hypercoagulability among patients with Wegener's granulomatosis with and without history of a thrombotic event.
The Journal of rheumatology 2007;34(12):2446-50.
2007: Silvia S Pierangeli; Mariano Vega-Ostertag; Elena Raschi; Xiaowei Liu; Zurina Romay-Penabad; Valeria De Micheli; Monica Galli; Marco Moia; Angela Tincani; Maria Orietta Borghi; Tracy Nguyen-Oghalai; Pier Luigi Meroni
Toll-like receptor and antiphospholipid mediated thrombosis: in vivo studies.
Annals of the rheumatic diseases 2007;66(10):1327-33.
2007: Mariano Vega-Ostertag; Dardo E Ferrara; Zurina Romay-Penabad; Xiaowei Liu; W. Robert Taylor; Margaret Stanfield; Silvia S Pierangeli
Role of p38 mitogen-activated protein kinase in antiphospholipid antibody-mediated thrombosis and endothelial cell activation.
Journal of thrombosis and haemostasis : JTH 2007;5(9):1828-34.
2007: Zurina Romay-Penabad; Xiaowei X Liu; Guadalupe Montiel-Manzano; Elizabeth Papalardo De Martínez; Silvia S Pierangeli
C5a receptor-deficient mice are protected from thrombophilia and endothelial cell activation induced by some antiphospholipid antibodies.
Annals of the New York Academy of Sciences 2007;1108():554-66.
2007: Guadalupe Montiel-Manzano; Zurina Romay-Penabad; E Papalardo de Martínez; L A Meillon-García; Ethel García-Latorre; Elba Reyes Maldonado; Silvia S Pierangeli
In vivo effects of an inhibitor of nuclear factor-kappa B on thrombogenic properties of antiphospholipid antibodies.
Annals of the New York Academy of Sciences 2007;1108():540-53.
2007: Mariano Vega-Ostertag; Silvia S Pierangeli
Mechanisms of aPL-mediated thrombosis: effects of aPL on endothelium and platelets.
Current rheumatology reports 2007;9(3):190-7.
2007: Jodi K Sebastian; Alfred Mahr; Sohail S Ahmed; John H Stone; Zurina Romay-Penabad; John C Davis; Gary S Hoffman; W Joseph McCune; E William St Clair; Ulrich Specks; Robert Spiera; Silvia S Pierangeli; Peter A Merkel
Antiendothelial cell antibodies in patients with Wegener's granulomatosis: prevalence and correlation with disease activity and manifestations.
The Journal of rheumatology 2007;34(5):1027-31.
2007: Iván Palomo; Jaime Pereira; Marcelo Alarcón; Marcela Vásquez; Carmen Pinochet; Fernando Poblete; Evelyn Mendez; Jeannette Sandoval; Rolando Vidal; Silvia S Pierangeli
Val/Leu247 and Trp/Ser316 polymorphisms in beta 2 glycoprotein I and their association with thrombosis in unselected Chilean patients.
Clinical rheumatology 2007;26(3):302-7.
2007: Silvia S Pierangeli; Mariano Vega-Ostertag; Emilio B González
New targeted therapies for treatment of thrombosis in antiphospholipid syndrome.
Expert reviews in molecular medicine 2007;9(30):1-15.
2006: Mariano Vega-Ostertag; Xiaowei Liu; Hwang Kwan-Ki; Pojen Chen; Silvia S Pierangeli
A human monoclonal antiprothrombin antibody is thrombogenic in vivo and upregulates expression of tissue factor and E-selectin on endothelial cells.
British journal of haematology 2006;135(2):214-9.
2006: Silvia S Pierangeli; Pojen P Chen; Emilio B González
Antiphospholipid antibodies and the antiphospholipid syndrome: an update on treatment and pathogenic mechanisms.
Current opinion in hematology 2006;13(5):366-75.
2006: Silvia S Pierangeli
In search for a receptor for antiphospholipid antibodies on target cells.
Journal of thrombosis and haemostasis : JTH 2006;4(8):1678-9.
2006: M Vega Ostertag; Xiaowei Liu; V Henderson; Silvia S Pierangeli
A peptide that mimics the Vth region of beta-2-glycoprotein I reverses antiphospholipid-mediated thrombosis in mice.
Lupus 2006;15(6):358-65.
2005: Silvia S Pierangeli; Guillermina Girardi; Mariano Vega-Ostertag; Xiaowei Liu; Ricardo G Espinola; Jane Salmon
Requirement of activation of complement C3 and C5 for antiphospholipid antibody-mediated thrombophilia.
Arthritis and rheumatism 2005;52(7):2120-4.
2005: Silvia S Pierangeli; E Nigel Harris
Clinical laboratory testing for the antiphospholipid syndrome.
Clinica chimica acta; international journal of clinical chemistry 2005;357(1):17-33.
2005: Silvia S Pierangeli; Mariano Vega-Ostertag; Xiaowei Liu; Guillermina Girardi
Complement activation: a novel pathogenic mechanism in the antiphospholipid syndrome.
Annals of the New York Academy of Sciences 2005;1051():413-20.
2005: Mariano Vega-Ostertag; Katie Casper; Robert Swerlick; Dardo E Ferrara; E Nigel Harris; Silvia S Pierangeli
Involvement of p38 MAPK in the up-regulation of tissue factor on endothelial cells by antiphospholipid antibodies.
Arthritis and rheumatism 2005;52(5):1545-54.
2005: Silvia S Pierangeli; Dardo E Ferrara
More on: fluvastatin inhibits up-regulation of tissue factor expression by antiphospholipid antibodies on endothelial cells.
Journal of thrombosis and haemostasis : JTH 2005;3(5):1112-3.
2005: Dardo E Ferrara; Silvia S Pierangeli
Diverse effects of statins on endothelial cells?
Thrombosis and haemostasis 2005;93(2):186-8.
2004: Mittermayer Santiago; Reinaldo Martinelli; Mitermayer G Reis; Eliana A G Reis; Albert Ko; Roberto Dias Fontes; Moacir Paranhos Silva; Elaine Goes Nascimento; Rogério de Jesus; Silvia S Pierangeli; Ricardo G Espinola; Azzudin E Gharavi
Diagnostic performance of anti-beta2 glycoprotein I and anticardiolipin assays for clinical manifestations of the antiphospholipid syndrome.
Clinical rheumatology 2004;23(6):485-9.
2004: Mariano Vega-Ostertag; E Nigel Harris; Silvia S Pierangeli
Intracellular events in platelet activation induced by antiphospholipid antibodies in the presence of low doses of thrombin.
Arthritis and rheumatism 2004;50(9):2911-9.
2004: Dardo E Ferrara; Robert Swerlick; Katie Casper; Pier Luigi Meroni; Mariano Vega-Ostertag; E Nigel Harris; Silvia S Pierangeli
Fluvastatin inhibits up-regulation of tissue factor expression by antiphospholipid antibodies on endothelial cells.
Journal of thrombosis and haemostasis : JTH 2004;2(9):1558-63.
2004: Silvia S Pierangeli; Miri Blank; Xiaowei Liu; Ricardo G Espinola; Mati Fridkin; Mariano Vega Ostertag; Karen Roye-Green; E Nigel Harris; Yehuda Shoenfeld
A peptide that shares similarity with bacterial antigens reverses thrombogenic properties of antiphospholipid antibodies in vivo.
Journal of autoimmunity 2004;22(3):217-25.
2004: Iván Palomo; Jaime Pereira; Marcelo Alarcón; Marcela Vásquez; Carmen Pinochet; María T Vélez; Jorge Sandoval; Gloria Icaza; Silvia S Pierangeli
Prevalence and isotype distribution of antiphospholipid antibodies in unselected Chilean patients with venous and arterial thrombosis.
Clinical rheumatology 2004;23(2):129-33.
2004: Silvia S Pierangeli; Mariano Vega-Ostertag; E Nigel Harris
Intracellular signaling triggered by antiphospholipid antibodies in platelets and endothelial cells: a pathway to targeted therapies.
Thrombosis research 2004;114(5-6):467-76.
2004: E Nigel Harris; Silvia S Pierangeli
Primary, Secondary, Catastrophic Antiphospholipid Syndrome: is there a difference?
Thrombosis research 2004;114(5-6):357-61.
2004: Azzudin E Gharavi; Mariano Vega-Ostertag; Ricardo G Espinola; Xiaowei Liu; L Cole; N T Cox; P Romagnoli; K Labat; Silvia S Pierangeli
Intrauterine fetal death in mice caused by cytomegalovirus-derived peptide induced aPL antibodies.
Lupus 2004;13(1):17-23.
2003: Dardo E Ferrara; Xiaowei Liu; Ricardo G Espinola; Pier Luigi Meroni; Imad Abukhalaf; E Nigel Harris; Silvia S Pierangeli
Inhibition of the thrombogenic and inflammatory properties of antiphospholipid antibodies by fluvastatin in an in vivo animal model.
Arthritis and rheumatism 2003;48(11):3272-9.
2003: Ricardo G Espinola; Xiaowei Liu; Margaret Stanfield; J Hall; E Nigel Harris; Silvia S Pierangeli
E-Selectin mediates pathogenic effects of antiphospholipid antibodies.
Journal of thrombosis and haemostasis : JTH 2003;1(4):843-8.
2003: Monica Smikle; Gilian Wharfe; Horace Fletcher; Marvin Reid; Karen Roye-Green; Joseph Fredrick; Silvia S Pierangeli
Anticardiolipin, other antiphospholipid antibody tests and diagnosis of the antiphospholipid syndrome.
Human antibodies 2003;12(3):63-6.
2003: Iván Palomo; Marcelo Alarcón; Cecilia Sepulveda; Jaime Pereira; Ricardo G Espinola; Silvia S Pierangeli
Prevalence of antiphospholipid and antiplatelet antibodies in human immunodeficiency virus (HIV)-infected Chilean patients.
Journal of clinical laboratory analysis 2003;17(6):209-15.
2003: Azzudin E Gharavi; W Wilson; Silvia S Pierangeli
The molecular basis of antiphospholipid syndrome.
Lupus 2003;12(8):579-83.
2003: Silvia S Pierangeli; E Nigel Harris
Probing antiphospholipid-mediated thrombosis: the interplay between anticardiolipin antibodies and endothelial cells.
Lupus 2003;12(7):539-45.
2003: Azzudin E Gharavi; Silvia S Pierangeli; E Nigel Harris
Viral origin of antiphospholipid antibodies: endothelial cell activation and thrombus enhancement by CMV peptide-induced APL antibodies.
Immunobiology 2003;207(1):37-42.
2002: Iván Palomo; Jaime Pereira; Marcelo Alarcón; Marcela Vasquez; Silvia S Pierangeli
Vascular access thrombosis is not related to presence of antiphospholipid antibodies in patients on chronic hemodialysis.
Nephron 2002;92(4):957-8.
2002: Iván Palomo; Jaime Pereira; Marcelo Alarcon; Ana Maria Larrain; Carmen Pinochet; Marcela Vasquez; Maria T Velez; M Leon; Ricardo G Espinola; Silvia S Pierangeli
Antiphospholipid antibodies in Chilean patients with systemic lupus erythematosus.
The Journal of laboratory and clinical medicine 2002;140(5):336-41.
2002: William Stohl; Gurtej S Cheema; William S Briggs; Dong Xu; Svetlana Sosnovtseva; Viktor Roschke; Dardo E Ferrara; Kimberly Labat; Fred R Sattler; Silvia S Pierangeli; David M Hilbert
B lymphocyte stimulator protein-associated increase in circulating autoantibody levels may require CD4+ T cells: lessons from HIV-infected patients.
Clinical immunology (Orlando, Fla.) 2002;104(2):115-22.
2002: Ricardo G Espinola; Silvia S Pierangeli; Azzudin E Gharavi; E Nigel Harris; Azzudin E Ghara
Hydroxychloroquine reverses platelet activation induced by human IgG antiphospholipid antibodies.
Thrombosis and haemostasis 2002;87(3):518-22.
2002: Azzudin E Gharavi; Silvia S Pierangeli; Ricardo G Espinola; Xiaowei Liu; Margaret Stanfield; E Nigel Harris
Antiphospholipid antibodies induced in mice by immunization with a cytomegalovirus-derived peptide cause thrombosis and activation of endothelial cells in vivo.
Arthritis and rheumatism 2002;46(2):545-52.
2002: V Michael Holers; Guillermina Girardi; Lian Mo; Guthridge Joel; Hector Molina; Silvia S Pierangeli; Ricardo G Espinola; Liu E Xiaowei; Dailing Mao; Christopher G Vialpando; Jane E Salmon
Complement C3 activation is required for antiphospholipid antibody-induced fetal loss.
The Journal of experimental medicine 2002;195(2):211-20.
2002: E Nigel Harris; Silvia S Pierangeli
Revisiting the anticardiolipin test and its standardization.
Lupus 2002;11(5):269-75.
2001: Azzudin E Gharavi; Silvia S Pierangeli; E Nigel Harris
Origin of antiphospholipid antibodies.
Rheumatic diseases clinics of North America 2001;27(3):551-63.
2001: Mittermayer Santiago; R Martinelli; Albert Ko; Eliana A G Reis; R D Fontes; E G Nascimento; Silvia S Pierangeli; Ricardo G Espinola; Azzudin E Gharavi
Anti-beta2 glycoprotein I and anticardiolipin antibodies in leptospirosis, syphilis and Kala-azar.
Clinical and experimental rheumatology 2001;19(4):425-30.
2001: Silvia S Pierangeli; Ricardo G Espinola; Xiaowei Liu; E Nigel Harris; Jane E Salmon
Identification of an Fc gamma receptor-independent mechanism by which intravenous immunoglobulin ameliorates antiphospholipid antibody-induced thrombogenic phenotype.
Arthritis and rheumatism 2001;44(4):876-83.
2001: Silvia S Pierangeli; Azzudin E Gharavi; E Nigel Harris
Testing for antiphospholipid antibodies: problems and solutions.
Clinical obstetrics and gynecology 2001;44(1):48-57; quiz 58-9.
2001: Azzudin E Gharavi; Silvia S Pierangeli; R A Levy; E Nigel Harris
Mechanisms of pregnancy loss in antiphospholipid syndrome.
Clinical obstetrics and gynecology 2001;44(1):11-9.
2001: Silvia S Pierangeli; Ricardo G Espinola; Xiaowei Liu; E Nigel Harris
Thrombogenic effects of antiphospholipid antibodies are mediated by intercellular cell adhesion molecule-1, vascular cell adhesion molecule-1, and P-selectin.
Circulation research 2001;88(2):245-50.
2000: Silvia S Pierangeli; Xiaowei Liu; Ricardo G Espinola; T Olee; M Zhu; N E Harris; Pojen P Chen
Functional analyses of patient-derived IgG monoclonal anticardiolipin antibodies using in vivo thrombosis and in vivo microcirculation models.
Thrombosis and haemostasis 2000;84(3):388-95.
2000: Silvia S Pierangeli; Azzudin E Gharavi; E Nigel Harris
Experimental thrombosis and antiphospholipid antibodies: new insights.
Journal of autoimmunity 2000;15(2):241-7.
2000: Azzudin E Gharavi; Silvia S Pierangeli; E Nigel Harris
New developments in viral peptides and APL induction.
Journal of autoimmunity 2000;15(2):227-30.
2000: E Nigel Harris; Silvia S Pierangeli
'Equivocal' antiphospholipid syndrome.
Journal of autoimmunity 2000;15(2):81-5.
1999: Xiaowei Liu; F W Peter; John Barker; Silvia S Pierangeli; E Nigel Harris; Gary L Anderson
Leukocyte-endothelium interaction in arterioles after ischemia and reperfusion.
The Journal of surgical research 1999;87(1):77-84.
1999: Azzudin E Gharavi; Silvia S Pierangeli; Margaret Stanfield; X W Liu; Ricardo G Espinola; E Nigel Harris
GDKV-induced antiphospholipid antibodies enhance thrombosis and activate endothelial cells in vivo and in vitro.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(5):2922-7.
1999: Silvia S Pierangeli; Margaret Stanfield; Xiaowei Liu; John Barker; G L Anderson; E Nigel Harris
Antiphospholipid antibodies from antiphospholipid syndrome patients activate endothelial cells in vitro and in vivo.
Circulation 1999;99(15):1997-2002.
1998: X W Liu; Silvia S Pierangeli; J Barker; Timothy M Wick; Lewis Hsu
RBC adhesion to cremaster endothelum in mice with abnormal hemoglobin is increased by topical endotoxin.
Annals of the New York Academy of Sciences 1998;850():391-3.
1998: E Nigel Harris; Silvia S Pierangeli; Azzudin E Gharavi
Diagnosis of the antiphospholipid syndrome: a proposal for use of laboratory tests.
Lupus 1998;7 Suppl 2():S144-8.
1998: Azzudin E Gharavi; Silvia S Pierangeli
Origin of antiphospholipid antibodies: induction of aPL by viral peptides.
Lupus 1998;7 Suppl 2():S52-4.
1998: E Nigel Harris; Silvia S Pierangeli
Utilization of intravenous immunoglobulin therapy to treat recurrent pregnancy loss in the antiphospholipid syndrome: a review.
Scandinavian journal of rheumatology. Supplement 1998;107():97-102.
1998: Silvia S Pierangeli; M Stewart; L K Silva; E Nigel Harris
An antiphospholipid wet workshop: 7th International Symposium on Antiphospholipid Antibodies.
The Journal of rheumatology 1998;25(1):156-60.
1997: E Nigel Harris; Silvia S Pierangeli
Antiphospholipid antibodies and cerebral lupus.
Annals of the New York Academy of Sciences 1997;823():270-8.
1997: Silvia S Pierangeli; G H Goldsmith; D Ware Branch; E Nigel Harris
Antiphospholipid antibody: functional specificity for inhibition of prothrombin activation by the prothrombinase complex.
British journal of haematology 1997;97(4):768-74.