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Alessandro Piergentili

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Rosa Chung; Fabio Del Bello; Carmen Macsai; Alessandro Piergentili; Wilma Quaglia; Derick Wong; Cory J Xian
Roles of Wnt/β-catenin signalling pathway in the bony repair of injured growth plate cartilage in young rats.
Alessandro Bonifazi; Fabio Del Bello; Yogita Farande; Valerio Farfariello; Mario Giannella; Amedeo Leonardi; Sergio Menegon; Massimo Nabissi; Alessandro Piergentili; Maria Pigini; Elena Poggesi; Consuelo Amantini; Giorgio Santoni; Wilma Quaglia
Structure-activity relationships in 1,4-benzodioxan-related compounds. 11. (1) reversed enantioselectivity of 1,4-dioxane derivatives in α1-adrenergic and 5-HT1A receptor binding sites recognition.
Valerio Mammoli; Laura Mattioli; Marina Perfumi; Alessandro Piergentili; Alessandro Bonifazi; Fabio Del Bello; Eleonora Diamanti; Mario Giannella; Alan L Hudson; Wilma Quaglia; Federica Titomanlio; Maria Pigini
Favourable involvement of α2A-adrenoreceptor antagonism in the I₂-imidazoline binding sites-mediated morphine analgesia enhancement.

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2013: Rosa Chung; Fabio Del Bello; Carmen Macsai; Alessandro Piergentili; Wilma Quaglia; Derick Wong; Cory J Xian
Roles of Wnt/β-catenin signalling pathway in the bony repair of injured growth plate cartilage in young rats.
Bone 2013;52(2):651-8.
2013: Alessandro Bonifazi; Fabio Del Bello; Yogita Farande; Valerio Farfariello; Mario Giannella; Amedeo Leonardi; Sergio Menegon; Massimo Nabissi; Alessandro Piergentili; Maria Pigini; Elena Poggesi; Consuelo Amantini; Giorgio Santoni; Wilma Quaglia
Structure-activity relationships in 1,4-benzodioxan-related compounds. 11. (1) reversed enantioselectivity of 1,4-dioxane derivatives in α1-adrenergic and 5-HT1A receptor binding sites recognition.
Journal of medicinal chemistry 2013;56(2):584-8.
2012: Valerio Mammoli; Laura Mattioli; Marina Perfumi; Alessandro Piergentili; Alessandro Bonifazi; Fabio Del Bello; Eleonora Diamanti; Mario Giannella; Alan L Hudson; Wilma Quaglia; Federica Titomanlio; Maria Pigini
Favourable involvement of α2A-adrenoreceptor antagonism in the I₂-imidazoline binding sites-mediated morphine analgesia enhancement.
Bioorganic & medicinal chemistry 2012;20(7):2259-65.
2012: Eleonora Diamanti; Giuseppe Fracchiolla; Mario Giannella; Valerio Mammoli; Alessandro Piergentili; Giuseppe Carbonara; Antonio Carrieri; Fabio Del Bello; Katariina Pohjanoksa; Wilma Quaglia; Mika Scheinin; Maria Pigini
Might the observed α(2A)-adrenoreceptor agonism or antagonism of allyphenyline analogues be ascribed to different molecular conformations?
Bioorganic & medicinal chemistry 2012;20(6):2082-90.
2012: Fabio Del Bello; Mario Giannella; Rosanna Matucci; Marta Nesi; Elisabetta Barocelli; Simona Bertoni; Alessandro Bonifazi; Mercedes Camalli; Gaetano Campi; Maria Pigini; Wilma Quaglia; Alessandro Piergentili
1,4-dioxane, a suitable scaffold for the development of novel M₃ muscarinic receptor antagonists.
Journal of medicinal chemistry 2012;55(4):1783-7.
2011: Wilma Quaglia; Fabio Del Bello; Mario Giannella; Alessandro Piergentili; Maria Pigini
α2C-adrenoceptor modulators: a patent review.
Expert opinion on therapeutic patents 2011;21(4):455-81.
2010: Fabio Del Bello; Laura Mattioli; Francesca Ghelfi; Mario Giannella; Alessandro Piergentili; Wilma Quaglia; Claudia Cardinaletti; Marina Perfumi; Russell J Thomas; Ugo Zanelli; Carla Marchioro; Michele Dal Cin; Maria Pigini
Fruitful adrenergic α(2C)-agonism/α(2A)-antagonism combination to prevent and contrast morphine tolerance and dependence.
Journal of medicinal chemistry 2010;53(21):7825-35.
2010: Antonio Carrieri; Alessandro Piergentili; Fabio Del Bello; Mario Giannella; Maria Pigini; Amedeo Leonardi; Francesca Fanelli; Wilma Quaglia
Structure-activity relationships in 1,4-benzodioxan-related compounds. 10. Novel α1-adrenoreceptor antagonists related to openphendioxan: synthesis, biological evaluation, and α1d computational study.
Bioorganic & medicinal chemistry 2010;18(19):7065-77.
2010: Alessandro Piergentili; Consuelo Amantini; Fabio Del Bello; Mario Giannella; Laura Mattioli; Maura Palmery; Marina Perfumi; Maria Pigini; Giorgio Santoni; Paolo Tucci; Margherita Zotti; Wilma Quaglia
Novel highly potent and selective sigma 1 receptor antagonists related to spipethiane.
Journal of medicinal chemistry 2010;53(3):1261-9.
2009: Alessandro Piergentili; Wilma Quaglia; Fabio Del Bello; Mario Giannella; Maria Pigini; Elisabetta Barocelli; Simona Bertoni; Rosanna Matucci; Marta Nesi; Bruno Bruni; Massimo Di Vaira
Properly substituted 1,4-dioxane nucleus favours the selective M3 muscarinic receptor activation.
Bioorganic & medicinal chemistry 2009;17(24):8174-85.
2009: Claudia Cardinaletti; Laura Mattioli; Francesca Ghelfi; Fabio Del Bello; Mario Giannella; Ariana Bruzzone; Hervé Paris; Marina Perfumi; Alessandro Piergentili; Wilma Quaglia; Maria Pigini
Might adrenergic alpha2C-agonists/alpha2A-antagonists become novel therapeutic tools for pain treatment with morphine?
Journal of medicinal chemistry 2009;52(22):7319-22.
2008: Wilma Quaglia; Alessandro Piergentili; Fabio Del Bello; Yogita Farande; Mario Giannella; Maria Pigini; Giovanni Rafaiani; Antonio Carrieri; Consuelo Amantini; Roberta Lucciarini; Giorgio Santoni; Elena Poggesi; Amedeo Leonardi
Structure-activity relationships in 1,4-benzodioxan-related compounds. 9. From 1,4-benzodioxane to 1,4-dioxane ring as a promising template of novel alpha1D-adrenoreceptor antagonists, 5-HT1A full agonists, and cytotoxic agents.
Journal of medicinal chemistry 2008;51(20):6359-70.
2008: Gianfabio Giorgioni; Alessandro Piergentili; S Ruggieri; W Quaglia
Dopamine D5 receptors: a challenge to medicinal chemists.
Mini reviews in medicinal chemistry 2008;8(10):976-95.
2008: Francesco Gentili; Claudia Cardinaletti; Cristian Vesprini; Francesca Ghelfi; Aniket Farande; Mario Giannella; Alessandro Piergentili; Wilma Quaglia; Laura Mattioli; Marina Perfumi; Alan Hudson; Maria Pigini
Novel ligands rationally designed for characterizing I2-imidazoline binding sites nature and functions.
Journal of medicinal chemistry 2008;51(16):5130-4.
2008: Francesco Gentili; Claudia Cardinaletti; Cristian Vesprini; Antonio Carrieri; Francesca Ghelfi; Aniket Farande; Mario Giannella; Alessandro Piergentili; Wilma Quaglia; Jonne M Laurila; Anna Huhtinen; Mika Scheinin; Maria Pigini
Alpha2-adrenoreceptors profile modulation. 4. From antagonist to agonist behavior.
Journal of medicinal chemistry 2008;51(14):4289-99.
2008: Alessandro Piergentili; Wilma Quaglia; Mario Giannella; Fabio Del Bello; Michela Buccioni; Marta Nesi; Rosanna Matucci
Rapid novel divergent synthesis and muscarinic agonist profile of all four optical isomers of N,N,N-trimethyl(6-methyl-1,4-dioxan-2-yl)methanaminium iodide.
Bioorganic & medicinal chemistry letters 2008;18(2):614-8.
2007: David I Fletcher; C Robin Ganellin; Alessandro Piergentili; Philip M Dunn; Donald H Jenkinson
Synthesis and pharmacological testing of polyaminoquinolines as blockers of the apamin-sensitive Ca2+-activated K+ channel (SK(Ca)).
Bioorganic & medicinal chemistry 2007;15(16):5457-79.
2007: Pierre-Antoine Crassous; Claudia Cardinaletti; Antonio Carrieri; Bruno Bruni; Massimo Di Vaira; Francesco Gentili; Francesca Ghelfi; Mario Giannella; Hervé Paris; Alessandro Piergentili; Wilma Quaglia; Stéphane Schaak; Cristian Vesprini; Maria Pigini
Alpha2-adrenoreceptors profile modulation. 3.1 (R)-(+)-m-nitrobiphenyline, a new efficient and alpha2C-subtype selective agonist.
Journal of medicinal chemistry 2007;50(16):3964-8.
2007: Alessandro Piergentili; Wilma Quaglia; Mario Giannella; Fabio Del Bello; Bruno Bruni; Michela Buccioni; Antonio Carrieri; Samuele Ciattini
Dioxane and oxathiane nuclei: suitable substructures for muscarinic agonists.
Bioorganic & medicinal chemistry 2007;15(2):886-96.
2007: Francesco Gentili; Maria Pigini; Alessandro Piergentili; Mario Giannella
Agonists and antagonists targeting the different alpha2-adrenoceptor subtypes.
Current topics in medicinal chemistry 2007;7(2):163-86.
2005: Wilma Quaglia; Giorgio Santoni; Maria Pigini; Alessandro Piergentili; Francesco Gentili; Michela Buccioni; Michela Mosca; Roberta Lucciarini; Consuelo Amantini; Massimo Ivan Nabissi; Patrizia Ballarini; Elena Poggesi; Amedeo Leonardi; Mario Giannella
Structure-activity relationships in 1,4-benzodioxan-related compounds. 8.(1) {2-[2-(4-chlorobenzyloxy)phenoxy]ethyl}-[2-(2,6-dimethoxyphenoxy)ethyl]amine (clopenphendioxan) as a tool to highlight the involvement of alpha1D- and alpha1B-adrenoreceptor subtypes in the regulation of human PC-3 prostate cancer cell apoptosis and proliferation.
Journal of medicinal chemistry 2005;48(24):7750-63.
2004: Francesco Gentili; Francesca Ghelfi; Mario Giannella; Alessandro Piergentili; Maria Pigini; Wilma Quaglia; Cristian Vesprini; Pierre-Antoine Crassous; Hervé Paris; Antonio Carrieri
alpha 2-adrenoreceptors profile modulation. 2. Biphenyline analogues as tools for selective activation of the alpha 2C-subtype.
Journal of medicinal chemistry 2004;47(25):6160-73.
2003: Alessandro Piergentili; Francesco Gentili; Francesca Ghelfi; Gabriella Marucci; Maria Pigini; Wilma Quaglia; Mario Giannella
Muscarinic subtypes profile modulation within a series of new antagonists, bridged bicyclic derivatives of 2,2-diphenyl-[1,3]-dioxolan-4-ylmethyl-dimethylamine.
Bioorganic & medicinal chemistry 2003;11(18):3901-11.
2003: Francesco Gentili; Pascal Bousquet; Livio Brasili; Monique Dontenwill; Josiane Feldman; Francesca Ghelfi; Mario Giannella; Alessandro Piergentili; Wilma Quaglia; Maria Pigini
Imidazoline binding sites (IBS) profile modulation: key role of the bridge in determining I1-IBS or I2-IBS selectivity within a series of 2-phenoxymethylimidazoline analogues.
Journal of medicinal chemistry 2003;46(11):2169-76.
2003: G Ferretti; Malgorzata Dukat; Mario Giannella; Alessandro Piergentili; Maria Pigini; Wilma Quaglia; M Imad Damaj; Billy R Martin; Richard A Glennon
Binding of nicotine and homoazanicotine analogues at neuronal nicotinic acetylcholinergic (nACh) receptors.
Bioorganic & medicinal chemistry letters 2003;13(4):733-5.
2002: G Ferretti; Malgorzata Dukat; Mario Giannella; Alessandro Piergentili; Maria Pigini; Wilma Quaglia; M Imad Damaj; B R Martin; Richard A Glennon
Homoazanicotine: a structure-affinity study for nicotinic acetylcholine (nACh) receptor binding.
Journal of medicinal chemistry 2002;45(21):4724-31.
2002: Wilma Quaglia; Maria Pigini; Alessandro Piergentili; Mario Giannella; Francesco Gentili; Gabriella Marucci; Antonio Carrieri; Angelo Carotti; Elena Poggesi; Amedeo Leonardi; Carlo Melchiorre
Structure-activity relationships in 1,4-benzodioxan-related compounds. 7. Selectivity of 4-phenylchroman analogues for alpha(1)-adrenoreceptor subtypes.
Journal of medicinal chemistry 2002;45(8):1633-43.
2002: Piero Angeli; Gabriella Marucci; Michela Buccioni; Alessandro Piergentili; Mario Giannella; Wilma Quaglia; Maria Pigini; Franco Cantalamessa; Cinzia Nasuti; Francesca Novi; Roberto Maggio; Ahmed Qasem; santi spampinato
Deoxamuscaroneoxime derivatives as useful muscarinic agonists to explore the muscarinic subsite: demox, a modulator of orthosteric and allosteric sites at cardiac muscarinic M2 receptors.
Life sciences 2002;70(12):1427-46.
2002: Francesco Gentili; Pascal Bousquet; Livio Brasili; Mariangela Caretto; Antonio Carrieri; Monique Dontenwill; Mario Giannella; Gabriella Marucci; Marina Perfumi; Alessandro Piergentili; Wilma Quaglia; Carla Rascente; Maria Pigini
Alpha2-adrenoreceptors profile modulation and high antinociceptive activity of (S)-(-)-2-[1-(biphenyl-2-yloxy)ethyl]-4,5-dihydro-1H-imidazole.
Journal of medicinal chemistry 2002;45(1):32-40.
2000: G Ferretti; Malgorzata Dukat; Mario Giannella; Alessandro Piergentili; Maria Pigini; Wilma Quaglia; M Imad Damaj; B R Martin; Richard A Glennon
Chain-lengthened and imidazoline analogues of nicotine.
Bioorganic & medicinal chemistry letters 2000;10(23):2665-8.
2000: J Campos Rosa; Dimitrios Galanakis; Alessandro Piergentili; K Bhandari; C Robin Ganellin; Philip M Dunn; Donald H Jenkinson
Synthesis, molecular modeling, and pharmacological testing of bis-quinolinium cyclophanes: potent, non-peptidic blockers of the apamin-sensitive Ca(2+)-activated K(+) channel.
Journal of medicinal chemistry 2000;43(3):420-31.
1999: Wilma Quaglia; Maria Pigini; Alessandro Piergentili; Mario Giannella; Gabriella Marucci; Elena Poggesi; Amedeo Leonardi; Carlo Melchiorre
Structure-activity relationships in 1,4-benzodioxan-related compounds. 6. Role of the dioxane unit on selectivity for alpha(1)-adrenoreceptor subtypes.
Journal of medicinal chemistry 1999;42(15):2961-8.
1999: Wilma Quaglia; Pascal Bousquet; Maria Pigini; Angelo Carotti; Antonio Carrieri; Monique Dontenwill; Francesco Gentili; Mario Giannella; F Maranca; Alessandro Piergentili; Livio Brasili
2-(2-Phenylcyclopropyl)imidazolines: reversed enantioselective interaction at I(1) and I(2) imidazoline receptors.
Journal of medicinal chemistry 1999;42(15):2737-40.
1999: Maria Pigini; Pascal Bousquet; Livio Brasili; Antonio Carrieri; Monique Dontenwill; Francesco Gentili; Mario Giannella; F Leonetti; Alessandro Piergentili; Wilma Quaglia; Angelo Carotti
Binding of tracizolines to the imidazoline receptor. Role of lipophilicity in quantitative structure-activity relationship models.
Annals of the New York Academy of Sciences 1999;881():118-22.
1999: Seyed Khosrow Tayebati; Alessandro Piergentili; D Natale; Francesco Amenta
Evaluation of an agonist index: affinity ratio for compounds active on muscarinic cholinergic M2 receptors.
Journal of autonomic pharmacology 1999;19(2):77-84.
1998: Maria Pigini; Pascal Bousquet; Livio Brasili; Antonio Carrieri; R Cavagna; Monique Dontenwill; Francesco Gentili; Mario Giannella; F Leonetti; Alessandro Piergentili; Wilma Quaglia; Angelo Carotti
Ligand binding to I2 imidazoline receptor: the role of lipophilicity in quantitative structure-activity relationship models.
Bioorganic & medicinal chemistry 1998;6(12):2245-60.
1998: Wilma Quaglia; Mario Giannella; Alessandro Piergentili; Maria Pigini; Livio Brasili; Rosanna Di Toro; L Rossetti; santi spampinato; Carlo Melchiorre
1'-Benzyl-3,4-dihydrospiro[2H-1- benzothiopyran-2,4'-piperidine] (spipethiane), a potent and highly selective sigma1 ligand.
Journal of medicinal chemistry 1998;41(10):1557-60.
1997: Seyed Khosrow Tayebati; Mario Giannella; Alessandro Piergentili; Maria Pigini; Wilma Quaglia; M Sabbatini; Francesco Amenta
Use of frozen sections for the pharmacological characterization of compounds active on neurotransmitter receptors.
Clinical and experimental hypertension (New York, N.Y. : 1993) 1997;19(7):1023-46.
1997: Maria Pigini; Pascal Bousquet; Angelo Carotti; Monique Dontenwill; Mario Giannella; R Moriconi; Alessandro Piergentili; Wilma Quaglia; Seyed Khosrow Tayebati; Livio Brasili
Imidazoline receptors: qualitative structure-activity relationships and discovery of tracizoline and benazoline. Two ligands with high affinity and unprecedented selectivity.
Bioorganic & medicinal chemistry 1997;5(5):833-41.
1997: Piero Angeli; Livio Brasili; M L Cingolani; Gabriella Marucci; Alessandro Piergentili; Maria Pigini; Wilma Quaglia
Synthesis and structure-activity relationship studies in a series of 2-substituted 1,3-dioxolanes modified at the cationic head.
Bioorganic & medicinal chemistry 1997;5(4):731-7.
1996: Alessandro Piergentili; Maria Pigini; Wilma Quaglia; Seyed Khosrow Tayebati; Francesco Amenta; Maurizio Sabbatini; Mario Giannella
Muscarinic thioligands with cyclopentane nucleus.
Bioorganic & medicinal chemistry 1996;4(12):2193-9.
1996: Wilma Quaglia; Maria Pigini; Seyed Khosrow Tayebati; Alessandro Piergentili; Mario Giannella; Amedeo Leonardi; C Taddei; Carlo Melchiorre
Synthesis, absolute configuration, and biological profile of the enantiomers of trans-[2-(2,6-dimethoxyphenoxy)ethyl] [(3-p-tolyl-2,3-dihydro-1,4-benzodioxin-2-yl)methyl]amine (mephendioxan), a potent competitive alpha 1A-adrenoreceptor antagonist.
Journal of medicinal chemistry 1996;39(11):2253-8.
1996: Alessandro Piergentili; Piero Angeli; Mario Giannella; Maria Pigini; Wilma Quaglia; Seyed Khosrow Tayebati
Bicyclic dioxolanes as potential antimuscarinic agents.
Arzneimittel-Forschung 1996;46(2):99-105.
1996: Wilma Quaglia; Mario Giannella; Gabriella Marucci; Alessandro Piergentili; Maria Pigini; Seyed Khosrow Tayebati; Carlo Melchiorre
Structure-activity relationships in 1,4-benzodioxan-related compounds. 5. Effects of modification of the side chain on alpha-adrenoreceptor blocking activity.
Farmaco (Società chimica italiana : 1989) 1996;51(1):27-32.
1994: Mario Giannella; Alessandro Piergentili; Maria Pigini; Wilma Quaglia; G Rafaiani; Seyed Khosrow Tayebati
Synthesis and muscarinic properties of (1S*,3R*,5R*)-trimethyl(1-methyl-6-oxabicyclo[3.1.0]hex-3-yl)methyl ammonium iodide.
Chemical & pharmaceutical bulletin 1994;42(6):1286-90.
1994: Alessandro Piergentili; Wilma Quaglia; Seyed Khosrow Tayebati; F Paparelli; L Malmusi; Livio Brasili
Synthesis and muscarinic receptors affinity of a series of antagonist bivalent ligands.
Farmaco (Società chimica italiana : 1989) 1994;49(2):83-7.
1993: Carlo De Micheli; Marco De Amici; E Grana; F Zonta; Mario Giannella; Alessandro Piergentili
Synthesis and muscarinic activity of some muscarone analogs.
Farmaco (Società chimica italiana : 1989) 1993;48(10):1333-48.
1993: Wilma Quaglia; Maria Pigini; Seyed Khosrow Tayebati; Alessandro Piergentili; Mario Giannella; Gabriella Marucci; Carlo Melchiorre
Structure-activity relationships in 1,4-benzodioxan-related compounds. 4. Effect of aryl and alkyl substituents at position 3 on alpha-adrenoreceptor blocking activity.
Journal of medicinal chemistry 1993;36(11):1520-8.
1990: F Claudi; M Cardellini; G M Cingolani; Alessandro Piergentili; G Peruzzi; Walter Balduini
Synthesis and dopamine receptor affinities of 2-(4-fluoro-3- hydroxyphenyl)ethylamine and N-substituted derivatives.
Journal of medicinal chemistry 1990;33(9):2408-12.