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Aldert Piersma

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Chemicals & Drugs

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Aldert H Piersma; M J E Roelofs; S H W Schulpen; M Schwarz; F Uibel; Sieto Bosgra; S A B Hermsen; L R A Jonker; ED Kroese; H Man; S C van der Linden; Majorie B M van Duursen; B M A van Vugt-Lussenburg; J Westerhout; A P M Wolterbeek; B van der Burg
Evaluation of an alternative in vitro test battery for detecting reproductive toxicants.
Maarke J E Roelofs; Martin van den Berg; Aldert H Piersma; Majorie B M van Duursen
The relevance of chemical interactions with CYP17 enzyme activity: assessment using a novel in vitro assay.
Peter T Theunissen; Dorien A M van Dartel; Jos C S Kleinjans; Jeroen L A Pennings; Joshua F Robinson; Aldert H Piersma
Complementary detection of embryotoxic properties of substances in the neural and cardiac embryonic stem cell tests.

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2013: Aldert H Piersma; M J E Roelofs; S H W Schulpen; M Schwarz; F Uibel; Sieto Bosgra; S A B Hermsen; L R A Jonker; ED Kroese; H Man; S C van der Linden; Majorie B M van Duursen; B M A van Vugt-Lussenburg; J Westerhout; A P M Wolterbeek; B van der Burg
Evaluation of an alternative in vitro test battery for detecting reproductive toxicants.
Reproductive toxicology (Elmsford, N.Y.) 2013;38():53-64.
2013: Maarke J E Roelofs; Martin van den Berg; Aldert H Piersma; Majorie B M van Duursen
The relevance of chemical interactions with CYP17 enzyme activity: assessment using a novel in vitro assay.
Toxicology and applied pharmacology 2013;268(3):309-17.
2013: Peter T Theunissen; Dorien A M van Dartel; Jos C S Kleinjans; Jeroen L A Pennings; Joshua F Robinson; Aldert H Piersma
Complementary detection of embryotoxic properties of substances in the neural and cardiac embryonic stem cell tests.
Toxicological sciences : an official journal of the Society of Toxicology 2013;132(1):118-30.
2013: Elisa C M Tonk; Didima M G de Groot; André H Penninks; Aldert H Piersma; Ine D H Waalkens-Berendsen; André P M Wolterbeek; Henk Van Loveren
Developmental immunotoxicity of ethanol in an extended one-generation reproductive toxicity study.
Archives of toxicology 2013;87(2):323-35.
2013: Mirjam Luijten; Jeroen L A Pennings; Aldert H Piersma; M Michele Pisano; Amar V Singh; Aart Verhoef; Anja Westerman; Caleb A Bastian; Annemieke de Vries; Maia L Green; Thomas B Knudsen
Lasting effects on body weight and mammary gland gene expression in female mice upon early life exposure to n-3 but not n-6 high-fat diets.
PloS one 2013;8(2):e55603.
2013: Kristina M Hettne; Jos C S Kleinjans; André Boorsma; Esther de Jong; Jelle J Goeman; Aldert H Piersma; Rob H Stierum; Dorien A M van Dartel; Jan A Kors
Next-generation text-mining mediated generation of chemical response-specific gene sets for interpretation of gene expression data.
BMC medical genomics 2013;6():2.
2013: Joshua F Robinson; Aldert H Piersma
Toxicogenomic approaches in developmental toxicology testing.
Methods in molecular biology (Clifton, N.J.) 2013;947():451-73.
2013: Sjors H W Schulpen; Aldert H Piersma
The embryonic stem cell test.
Methods in molecular biology (Clifton, N.J.) 2013;947():375-82.
2013: Aldert H Piersma
Innovations in testing strategies in reproductive toxicology.
Methods in molecular biology (Clifton, N.J.) 2013;947():327-41.
2013: Sjors H W Schulpen; Dorien A M van Dartel; Jeroen L A Pennings; Joshua F Robinson; Aldert H Piersma
Dose response analysis of monophthalates in the murine embryonic stem cell test assessed by cardiomyocyte differentiation and gene expression.
Reproductive toxicology (Elmsford, N.Y.) 2013;35():81-8.
2012: Aldert H Piersma; Elisa C M Tonk; Kevin M Crofton; Rodney R Dietert; Susan L Makris; Henk Van Loveren
Juvenile toxicity testing protocols for chemicals.
Reproductive toxicology (Elmsford, N.Y.) 2012;34(3):482-6.
2012: Jeroen L A Pennings; Peter T Theunissen; Aldert H Piersma
An optimized gene set for transcriptomics based neurodevelopmental toxicity prediction in the neural embryonic stem cell test.
Toxicology 2012;300(3):158-67.
2012: Joshua F Robinson; Vincent A van Beelen; Aart Verhoef; Jeroen L A Pennings; Aldert H Piersma
Dose-response analysis of phthalate effects on gene expression in rat whole embryo culture.
Toxicology and applied pharmacology 2012;264(1):32-41.
2012: Esther de Jong; Lianne van Beek; Aldert H Piersma
Osteoblast differentiation of murine embryonic stem cells as a model to study the embryotoxic effect of compounds.
Toxicology in vitro : an international journal published in association with BIBRA 2012;26(6):970-8.
2012: Joshua F Robinson; Elisa C M Tonk; Aart Verhoef; Aldert H Piersma
Triazole induced concentration-related gene signatures in rat whole embryo culture.
Reproductive toxicology (Elmsford, N.Y.) 2012;34(2):275-83.
2012: Sanne A B Hermsen; Tessa E Pronk; Evert-Jan Van den Brandhof; Leo T M van der Ven; Aldert H Piersma
Triazole-induced gene expression changes in the zebrafish embryo.
Reproductive toxicology (Elmsford, N.Y.) 2012;34(2):216-24.
2012: E Rorije; F J W van Hienen; Theo Vermeire; Z C Dang; B H Hakkert; Aldert H Piersma
Relative parameter sensitivity in prenatal toxicity studies with substances classified as developmental toxicants.
Reproductive toxicology (Elmsford, N.Y.) 2012;34(2):284-90.
2012: P T Theunissen; Marcel H M van Herwijnen; J C S Kleinjans; Jeroen L A Pennings; J F Robinson; Aldert H Piersma
Compound-specific effects of diverse neurodevelopmental toxicants on global gene expression in the neural embryonic stem cell test (ESTn).
Toxicology and applied pharmacology 2012;262(3):330-40.
2012: Judith C Madden; Aldert H Piersma; Katarzyna Przybylak; Rob J Vandebriel; Mark Hewitt; Mark T D Cronin
Strategies for the optimisation of in vivo experiments in accordance with the 3Rs philosophy.
Regulatory toxicology and pharmacology : RTP 2012;63(1):140-54.
2012: Sanne A B Hermsen; Tessa E Pronk; Evert-Jan Van den Brandhof; Leo T M van der Ven; Aldert H Piersma
Concentration-response analysis of differential gene expression in the zebrafish embryotoxicity test following flusilazole exposure.
Toxicological sciences : an official journal of the Society of Toxicology 2012;127(1):303-12.
2012: Elisa C M Tonk; Henk Van Loveren; Aart Verhoef; Eric R Gremmer; Aldert H Piersma
Relative sensitivity of developmental and immune parameters in juvenile versus adult male rats after exposure to di(2-ethylhexyl) phthalate.
Toxicology and applied pharmacology 2012;260(1):48-57.
2012: Joshua F Robinson; Aart Verhoef; Jeroen L A Pennings; Tessa E Pronk; Aldert H Piersma
A comparison of gene expression responses in rat whole embryo culture and in vivo: time-dependent retinoic acid-induced teratogenic response.
Toxicological sciences : an official journal of the Society of Toxicology 2012;126(1):242-54.
2012: Joshua F Robinson; Aart Verhoef; Aldert H Piersma
Transcriptomic analysis of neurulation and early organogenesis in rat embryos: an in vivo and ex vivo comparison.
Toxicological sciences : an official journal of the Society of Toxicology 2012;126(1):255-66.
2012: Peter T Theunissen; Joshua F Robinson; Sandra M H Claessen; Esther de Jong; Jos C S Kleinjans; Jeroen L A Pennings; Aldert H Piersma
Transcriptomic concentration-response evaluation of valproic acid, cyproconazole, and hexaconazole in the neural embryonic stem cell test (ESTn).
Toxicological sciences : an official journal of the Society of Toxicology 2012;125(2):430-8.
2012: Joshua F Robinson; Jeroen L A Pennings; Aldert H Piersma
A review of toxicogenomic approaches in developmental toxicology.
Methods in molecular biology (Clifton, N.J.) 2012;889():347-71.
2011: Elisa C M Tonk; Henk Van Loveren; Aart Verhoef; Ine D H Waalkens-Berendsen; André P M Wolterbeek; Liset J J de la Fonteyne; Aldert H Piersma
Developmental immunotoxicity in male rats after juvenile exposure to di-n-octyltin dichloride (DOTC).
Reproductive toxicology (Elmsford, N.Y.) 2011;32(3):341-8.
2011: Emiel Rorije; Erna Schenk; Beate Ulbrich; Manon E W Beekhuijzen; Betty C Hakkert; Ulla Hass; Barbara Heinrich-Hirsch; André Muller; Martin Paparella; Aldert H Piersma
On the impact of second generation mating and offspring in multi-generation reproductive toxicity studies on classification and labelling of substances in Europe.
Regulatory toxicology and pharmacology : RTP 2011;61(2):251-60.
2011: Peter T Theunissen; Joshua F Robinson; Sandra M H Claessen; Jos C S Kleinjans; Jeroen L A Pennings; Aldert H Piersma
Time-response evaluation by transcriptomics of methylmercury effects on neural differentiation of murine embryonic stem cells.
Toxicological sciences : an official journal of the Society of Toxicology 2011;122(2):437-47.
2011: Elisa C M Tonk; Didima M G de Groot; André H Penninks; Ine D H Waalkens-Berendsen; André P M Wolterbeek; Aldert H Piersma; Henk Van Loveren
Developmental immunotoxicity of di-n-octyltin dichloride (DOTC) in an extended one-generation reproductive toxicity study.
Toxicology letters 2011;204(2-3):156-63.
2011: Aldert H Piersma; Jan van Benthem; F X Rolaf van Leeuwen; Lya G Hernandez; J J Andre Muller; Theo G Vermeire; Marcel T M van Raaij
Reproductive toxicants have a threshold of adversity.
Critical reviews in toxicology 2011;41(6):545-54.
2011: Jeroen L A Pennings; Dorien A M van Dartel; Joshua F Robinson; Tessa E Pronk; Aldert H Piersma
Gene set assembly for quantitative prediction of developmental toxicity in the embryonic stem cell test.
Toxicology 2011;284(1-3):63-71.
2011: Esther de Jong; Marta Barenys; Sanne A B Hermsen; Aart Verhoef; Bernadette C Ossendorp; Jos G M Bessems; Aldert H Piersma
Comparison of the mouse Embryonic Stem cell Test, the rat Whole Embryo Culture and the Zebrafish Embryotoxicity Test as alternative methods for developmental toxicity testing of six 1,2,4-triazoles.
Toxicology and applied pharmacology 2011;253(2):103-11.
2011: Bart van der Burg; E Dinant Kroese; Aldert H Piersma
Towards a pragmatic alternative testing strategy for the detection of reproductive toxicants.
Reproductive toxicology (Elmsford, N.Y.) 2011;31(4):558–61.
2011: Aldert H Piersma; E Rorije; M E W Beekhuijzen; R Cooper; D J Dix; B Heinrich-Hirsch; M T Martin; E Mendez; A Muller; M Paparella; D Ramsingh; E Reaves; P Ridgway; E Schenk; L Stachiw; B Ulbrich; B C Hakkert
Combined retrospective analysis of 498 rat multi-generation reproductive toxicity studies: on the impact of parameters related to F1 mating and F2 offspring.
Reproductive toxicology (Elmsford, N.Y.) 2011;31(4):392-401.
2011: E de Jong; A M C M Doedée; M A Reis-Fernandes; H Nau; Aldert H Piersma
Potency ranking of valproic acid analogues as to inhibition of cardiac differentiation of embryonic stem cells in comparison to their in vivo embryotoxicity.
Reproductive toxicology (Elmsford, N.Y.) 2011;31(4):375-82.
2011: Sanne A B Hermsen; Evert-Jan Van den Brandhof; Leo T M van der Ven; Aldert H Piersma
Relative embryotoxicity of two classes of chemicals in a modified zebrafish embryotoxicity test and comparison with their in vivo potencies.
Toxicology in vitro : an international journal published in association with BIBRA 2011;25(3):745-53.
2011: Dorien A M van Dartel; Jeroen L A Pennings; Joshua F Robinson; Jos C S Kleinjans; Aldert H Piersma
Discriminating classes of developmental toxicants using gene expression profiling in the embryonic stem cell test.
Toxicology letters 2011;201(2):143-51.
2011: Dorien A M van Dartel; Jeroen L A Pennings; Liset J J de la Fonteyne; Karen J J Brauers; Sandra Claessen; Joost H van Delft; Jos C S Kleinjans; Aldert H Piersma
Concentration-dependent gene expression responses to flusilazole in embryonic stem cell differentiation cultures.
Toxicology and applied pharmacology 2011;251(2):110-8.
2011: Dorien A M van Dartel; Jeroen L A Pennings; Liset J J de la Fonteyne; Karen J J Brauers; Sandra Claessen; Joost H van Delft; Jos C S Kleinjans; Aldert H Piersma
Evaluation of developmental toxicant identification using gene expression profiling in embryonic stem cell differentiation cultures.
Toxicological sciences : an official journal of the Society of Toxicology 2011;119(1):126-34.
2011: Jeroen L A Pennings; Dorien A M van Dartel; Tessa E Pronk; Peter J M Hendriksen; Aldert H Piersma
Identification by gene coregulation mapping of novel genes involved in embryonic stem cell differentiation.
Stem cells and development 2011;20(1):115-26.
2010: George P Daston; Robert E Chapin; Anthony R Scialli; Aldert H Piersma; Edward W Carney; John M Rogers; Jan M Friedman
A different approach to validating screening assays for developmental toxicity.
Birth defects research. Part B, Developmental and reproductive toxicology 2010;89(6):526-30.
2010: Joshua F Robinson; Vincent A van Beelen; Aart Verhoef; Marc F J Renkens; Mirjam Luijten; Marcel H M van Herwijnen; Anja Westerman; Jeroen L A Pennings; Aldert H Piersma
Embryotoxicant-specific transcriptomic responses in rat postimplantation whole-embryo culture.
Toxicological sciences : an official journal of the Society of Toxicology 2010;118(2):675-85.
2010: Jochem Louisse; Esther de Jong; Johannes J M van de Sandt; Bas J Blaauboer; Ruud A Woutersen; Aldert H Piersma; Ivonne M C M Rietjens; Miriam Verwei
The use of in vitro toxicity data and physiologically based kinetic modeling to predict dose-response curves for in vivo developmental toxicity of glycol ethers in rat and man.
Toxicological sciences : an official journal of the Society of Toxicology 2010;118(2):470-84.
2010: Elisa C M Tonk; Didima M G de Groot; André H Penninks; Ine D H Waalkens-Berendsen; André P M Wolterbeek; Wout Slob; Aldert H Piersma; Henk Van Loveren
Developmental immunotoxicity of methylmercury: the relative sensitivity of developmental and immune parameters.
Toxicological sciences : an official journal of the Society of Toxicology 2010;117(2):325-35.
2010: Ahmed M Osman; Dorien A M van Dartel; Edwin Zwart; Marco Blokland; Jeroen L A Pennings; Aldert H Piersma
Proteome profiling of mouse embryonic stem cells to define markers for cell differentiation and embryotoxicity.
Reproductive toxicology (Elmsford, N.Y.) 2010;30(2):322-32.
2010: Mirjam Luijten; Vincent A van Beelen; Aart Verhoef; Marc F J Renkens; Marcel H M van Herwijnen; Anja Westerman; Frederik J Van Schooten; Jeroen L A Pennings; Aldert H Piersma
Transcriptomics analysis of retinoic acid embryotoxicity in rat postimplantation whole embryo culture.
Reproductive toxicology (Elmsford, N.Y.) 2010;30(2):333-40.
2010: Aldert H Piersma
Reproductive Toxicology. Editorial.
Reproductive toxicology (Elmsford, N.Y.) 2010;30(1):1.
2010: Dorien A M van Dartel; Jeroen L A Pennings; Liset J J de la Fonteyne; Marcel H van Herwijnen; Joost H van Delft; Frederik J Van Schooten; Aldert H Piersma
Monitoring developmental toxicity in the embryonic stem cell test using differential gene expression of differentiation-related genes.
Toxicological sciences : an official journal of the Society of Toxicology 2010;116(1):130-9.
2010: P T Theunissen; S H W Schulpen; D A M van Dartel; S A B Hermsen; Frederik J Van Schooten; Aldert H Piersma
An abbreviated protocol for multilineage neural differentiation of murine embryonic stem cells and its perturbation by methyl mercury.
Reproductive toxicology (Elmsford, N.Y.) 2010;29(4):383-92.
2010: Dorien A M van Dartel; Jeroen L A Pennings; Frederik J Van Schooten; Aldert H Piersma
Transcriptomics-based identification of developmental toxicants through their interference with cardiomyocyte differentiation of embryonic stem cells.
Toxicology and applied pharmacology 2010;243(3):420-8.
2009: Peter M J Bos; Polly E Boon; Hilko van der Voet; Gemma Janer; Aldert H Piersma; Beat Brüschweiler; Elsa Nielsen; Wout Slob
A semi-quantitative model for risk appreciation and risk weighing.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2009;47(12):2941-50.
2009: Margriet V D Z Park; Wijtske Annema; Anna Salvati; Anna Lesniak; Andreas Elsaesser; Clifford Barnes; George McKerr; C Vyvyan Howard; Iseult Lynch; Kenneth A Dawson; Aldert H Piersma; Wim H De Jong
In vitro developmental toxicity test detects inhibition of stem cell differentiation by silica nanoparticles.
Toxicology and applied pharmacology 2009;240(1):108-16.
2009: Dorien A M van Dartel; Nicole J L Zeijen; Liset J J de la Fonteyne; Frederik J Van Schooten; Aldert H Piersma
Disentangling cellular proliferation and differentiation in the embryonic stem cell test, and its impact on the experimental protocol.
Reproductive toxicology (Elmsford, N.Y.) 2009;28(2):254-61.
2009: Zhi-Chao Dang; Emiel Rorije; Thijs Hogen Esch; André Muller; Betty C Hakkert; Aldert H Piersma
Retrospective analysis of relative parameter sensitivity in multi-generation reproductive toxicity studies.
Reproductive toxicology (Elmsford, N.Y.) 2009;28(2):196-202.
2009: Esther de Jong; Jochem Louisse; Miriam Verwei; Bas J Blaauboer; Johannes J M van de Sandt; Ruud A Woutersen; Ivonne M C M Rietjens; Aldert H Piersma
Relative developmental toxicity of glycol ether alkoxy acid metabolites in the embryonic stem cell test as compared with the in vivo potency of their parent compounds.
Toxicological sciences : an official journal of the Society of Toxicology 2009;110(1):117-24.
2009: Dorien A M van Dartel; Jeroen L A Pennings; Peter J M Hendriksen; Frederik J Van Schooten; Aldert H Piersma
Early gene expression changes during embryonic stem cell differentiation into cardiomyocytes and their modulation by monobutyl phthalate.
Reproductive toxicology (Elmsford, N.Y.) 2009;27(2):93-102.
2009: Leo T M van der Ven; Ton van de Kuil; P E G Leonards; Wout Slob; Hellmuth Lilienthal; Sabina Litens; Maria Herlin; Helen Håkansson; Rocío F Cantón; Martin van den Berg; Theo J Visser; Henk Van Loveren; Joseph G Vos; Aldert H Piersma
Endocrine effects of hexabromocyclododecane (HBCD) in a one-generation reproduction study in Wistar rats.
Toxicology letters 2009;185(1):51-62.
2009: Hellmuth Lilienthal; Leo T M van der Ven; Aldert H Piersma; Joseph G Vos
Effects of the brominated flame retardant hexabromocyclododecane (HBCD) on dopamine-dependent behavior and brainstem auditory evoked potentials in a one-generation reproduction study in Wistar rats.
Toxicology letters 2009;185(1):63-72.
2008: Gemma Janer; Aart Verhoef; H D Gilsing; Aldert H Piersma
Use of the rat postimplantation embryo culture to assess the embryotoxic potency within a chemical category and to identify toxic metabolites.
Toxicology in vitro : an international journal published in association with BIBRA 2008;22(7):1797-805.
2008: Rocío F Cantón; Ad Peijnenburg; Ron L A P Hoogenboom; Aldert H Piersma; Leo T M van der Ven; Martin van den Berg; Marjoke Heneweer
Subacute effects of hexabromocyclododecane (HBCD) on hepatic gene expression profiles in rats.
Toxicology and applied pharmacology 2008;231(2):267-72.
2008: Mirjam Luijten; Aart Verhoef; Anja Westerman; Aldert H Piersma
Application of a metabolizing system as an adjunct to the rat whole embryo culture.
Toxicology in vitro : an international journal published in association with BIBRA 2008;22(5):1332-6.
2008: JA van Meeuwen; O van Son; Aldert H Piersma; Paul C de Jong; Martin van den Berg
Aromatase inhibiting and combined estrogenic effects of parabens and estrogenic effects of other additives in cosmetics.
Toxicology and applied pharmacology 2008;230(3):372-82.
2008: Leo T M van der Ven; Ton van de Kuil; P E G Leonards; Wout Slob; Rocío F Cantón; Silke Germer; Theo J Visser; Sabina Litens; Helen Håkansson; Dieter Schrenk; Martin van den Berg; Aldert H Piersma; Joseph G Vos; Antoon Opperhuizen
A 28-day oral dose toxicity study in Wistar rats enhanced to detect endocrine effects of decabromodiphenyl ether (decaBDE).
Toxicology letters 2008;179(1):6-14.
2008: JA van Meeuwen; Sandra Nijmeijer; T Mutarapat; S Ruchirawat; Paul C de Jong; Aldert H Piersma; Martin van den Berg
Aromatase inhibition by synthetic lactones and flavonoids in human placental microsomes and breast fibroblasts--a comparative study.
Toxicology and applied pharmacology 2008;228(3):269-76.
2008: Hellmuth Lilienthal; Cynthia M Verwer; Leo T M van der Ven; Aldert H Piersma; Joseph G Vos
Exposure to tetrabromobisphenol A (TBBPA) in Wistar rats: neurobehavioral effects in offspring from a one-generation reproduction study.
Toxicology 2008;246(1):45-54.
2008: Leo T M van der Ven; Ton van de Kuil; Aart Verhoef; Cynthia M Verwer; Hellmuth Lilienthal; P E G Leonards; Ute M D Schauer; Rocío F Cantón; Sabina Litens; Frank de Jong; Theo J Visser; Wolfgang Dekant; Natalia Stern; Helen Håkansson; Wout Slob; Martin van den Berg; Joseph G Vos; Aldert H Piersma
Endocrine effects of tetrabromobisphenol-A (TBBPA) in Wistar rats as tested in a one-generation reproduction study and a subacute toxicity study.
Toxicology 2008;245(1-2):76-89.
2008: Leo T M van der Ven; Ton van de Kuil; Aart Verhoef; P E G Leonards; Wout Slob; Rocío F Cantón; Silke Germer; Timo Hamers; Theo J Visser; Sabina Litens; Helen Håkansson; Yvonne Fery; Dieter Schrenk; Martin van den Berg; Aldert H Piersma; Joseph G Vos
A 28-day oral dose toxicity study enhanced to detect endocrine effects of a purified technical pentabromodiphenyl ether (pentaBDE) mixture in Wistar rats.
Toxicology 2008;245(1-2):109-22.
2008: Gemma Janer; Wout Slob; Betty C Hakkert; Theo Vermeire; Aldert H Piersma
A retrospective analysis of developmental toxicity studies in rat and rabbit: what is the added value of the rabbit as an additional test species?
Regulatory toxicology and pharmacology : RTP 2008;50(2):206-17.
2008: Anne-Maj Samuelsson; Phillippa A Matthews; Marco Argenton; Michael R Christie; Josie M McConnell; Eugene H J M Jansen; Aldert H Piersma; Susan E Ozanne; Denise Fernandez Twinn; Claude Remacle; Anthea Rowlerson; Lucilla Poston; Paul D Taylor
Diet-induced obesity in female mice leads to offspring hyperphagia, adiposity, hypertension, and insulin resistance: a novel murine model of developmental programming.
Hypertension 2008;51(2):383-92.
2008: Aldert H Piersma; Gemma Janer; Gerrit Wolterink; Jos G M Bessems; Betty C Hakkert; Wout Slob
Quantitative extrapolation of in vitro whole embryo culture embryotoxicity data to developmental toxicity in vivo using the benchmark dose approach.
Toxicological sciences : an official journal of the Society of Toxicology 2008;101(1):91-100.
2007: JA van Meeuwen; W Ter Burg; Aldert H Piersma; Martin van den Berg; J Thomas Sanderson
Mixture effects of estrogenic compounds on proliferation and pS2 expression of MCF-7 human breast cancer cells.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2007;45(11):2319-30.
2007: Gemma Janer; Betty C Hakkert; Aldert H Piersma; Theo Vermeire; Wout Slob
A retrospective analysis of the added value of the rat two-generation reproductive toxicity study versus the rat subchronic toxicity study.
Reproductive toxicology (Elmsford, N.Y.) 2007;24(1):103-13.
2007: Gemma Janer; Betty C Hakkert; Wout Slob; Theo Vermeire; Aldert H Piersma
A retrospective analysis of the two-generation study: what is the added value of the second generation?
Reproductive toxicology (Elmsford, N.Y.) 2007;24(1):97-102.
2007: JA van Meeuwen; N Korthagen; Paul C de Jong; Aldert H Piersma; Martin van den Berg
(Anti)estrogenic effects of phytochemicals on human primary mammary fibroblasts, MCF-7 cells and their co-culture.
Toxicology and applied pharmacology 2007;221(3):372-83.
2007: JA van Meeuwen; Martin van den Berg; J Thomas Sanderson; Aart Verhoef; Aldert H Piersma
Estrogenic effects of mixtures of phyto- and synthetic chemicals on uterine growth of prepubertal rats.
Toxicology letters 2007;170(2):165-76.
2007: Mirjam Luijten; Aart Verhoef; J A M A Dormans; Rudolf B Beems; Hans W J M Cremers; Nico J D Nagelkerke; Herman Adlercreutz; Jose Penalvo; Aldert H Piersma
Modulation of mammary tumor development in Tg.NK (MMTV/c-neu) mice by dietary fatty acids and life stage-specific exposure to phytoestrogens.
Reproductive toxicology (Elmsford, N.Y.) 2007;23(3):407-13.
2006: Leo T M van der Ven; Aart Verhoef; Ton van de Kuil; Wout Slob; P E G Leonards; Theo J Visser; Timo Hamers; Maria Herlin; Helen Håkansson; Hanna Olausson; Aldert H Piersma; Joseph G Vos
A 28-day oral dose toxicity study enhanced to detect endocrine effects of hexabromocyclododecane in Wistar rats.
Toxicological sciences : an official journal of the Society of Toxicology 2006;94(2):281-92.
2006: Horst Spielmann; Andrea Seiler; Susanne Bremer; Lars Hareng; Thomas Hartung; Hans Ahr; Elaine Faustman; Ulla Haas; Graeme J Moffat; Heinz Nau; Philippe Vanparys; Aldert H Piersma; Juan Riego Sintes; Jane Stuart
The practical application of three validated in vitro embryotoxicity tests. The report and recommendations of an ECVAM/ZEBET workshop (ECVAM workshop 57).
Alternatives to laboratory animals : ATLA 2006;34(5):527-38.
2006: Evelin Fabjan; Etje Hulzebos; W Mennes; Aldert H Piersma
A category approach for reproductive effects of phthalates.
Critical reviews in toxicology 2006;36(9):695-726.
2006: Aldert H Piersma
Alternative methods for developmental toxicity testing.
Basic & clinical pharmacology & toxicology 2006;98(5):427-31.
2006: Silke Germer; Aldert H Piersma; Leo T M van der Ven; Andreas Kamyschnikow; Yvonne Fery; Hans-Joachim Schmitz; Dieter Schrenk
Subacute effects of the brominated flame retardants hexabromocyclododecane and tetrabromobisphenol A on hepatic cytochrome P450 levels in rats.
Toxicology 2006;218(2-3):229-36.
2005: Wout Slob; Mirjam Moerbeek; Eija Rauniomaa; Aldert H Piersma
A statistical evaluation of toxicity study designs for the estimation of the benchmark dose in continuous endpoints.
Toxicological sciences : an official journal of the Society of Toxicology 2005;84(1):167-85.
2004: Aldert H Piersma; Elke Genschow; Aart Verhoef; Marielle Q I Spanjersberg; Nigel A Brown; Madeleine Brady; Angie Burns; Nicole Clemann; Andrea Seiler; Horst Spielmann
Validation of the postimplantation rat whole-embryo culture test in the international ECVAM validation study on three in vitro embryotoxicity tests.
Alternatives to laboratory animals : ATLA 2004;32(3):275-307.
2004: Horst Spielmann; Elke Genschow; Nigel A Brown; Aldert H Piersma; Aart Verhoef; Marielle Q I Spanjersberg; Hannele Huuskonen; Francoise Paillard; Andrea Seiler
Validation of the rat limb bud micromass test in the international ECVAM validation study on three in vitro embryotoxicity tests.
Alternatives to laboratory animals : ATLA 2004;32(3):245-74.
2004: Aldert H Piersma
Validation of alternative methods for developmental toxicity testing.
Toxicology letters 2004;149(1-3):147-53.
2004: Mirjam Moerbeek; Aldert H Piersma; Wout Slob
A comparison of three methods for calculating confidence intervals for the benchmark dose.
Risk analysis : an official publication of the Society for Risk Analysis 2004;24(1):31-40.
2004: Mirjam Luijten; Anni R Thomsen; Jolanda A H van den Berg; Piet W Wester; Aart Verhoef; Nico J D Nagelkerke; Herman Adlercreutz; Henk J van Kranen; Aldert H Piersma; Ilona K Sørensen; Ghanta N Rao; Coen F van Kreijl
Effects of soy-derived isoflavones and a high-fat diet on spontaneous mammary tumor development in Tg.NK (MMTV/c-neu) mice.
Nutrition and cancer 2004;50(1):46-54.
2004: Robert Kroes; Andrew G Renwick; M Cheeseman; J Kleiner; I Mangelsdorf; Aldert H Piersma; Benoît Schilter; Josef Schlatter; F van Schothorst; Joseph G Vos; G Würtzen
Structure-based thresholds of toxicological concern (TTC): guidance for application to substances present at low levels in the diet.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2004;42(1):65-83.
2003: Henk Van Loveren; Jeff Vos; Esther Putman; Aldert H Piersma
Immunotoxicological consequences of perinatal chemical exposures: a plea for inclusion of immune parameters in reproduction studies.
Toxicology 2003;185(3):185-91.
2002: M Siemelink; Aart Verhoef; J A M A Dormans; Paul Span; Aldert H Piersma
Dietary fatty acid composition during pregnancy and lactation in the rat programs growth and glucose metabolism in the offspring.
Diabetologia 2002;45(10):1397-403.
2002: Aldert H Piersma; Aart Verhoef; C G J Sweep; W H de Jong; H van Loveren
Developmental toxicity but no immunotoxicity in the rat after prenatal exposure to diethylstilbestrol.
Toxicology 2002;174(3):173-81.
2002: Elke Genschow; Horst Spielmann; Gabriele Scholz; Andrea Seiler; Nigel Brown; Aldert H Piersma; Madeleine Brady; Nicole Clemann; Hannele Huuskonen; Francoise Paillard; Susanne Bremer; Klaus Becker
The ECVAM international validation study on in vitro embryotoxicity tests: results of the definitive phase and evaluation of prediction models. European Centre for the Validation of Alternative Methods.
Alternatives to laboratory animals : ATLA 2002;30(2):151-76.
2001: Horst Spielmann; Elke Genschow; Gabriele Scholz; Nigel A Brown; Aldert H Piersma; Madeleine Brady; Nicole Clemann; Hannele Huuskonen; Francoise Paillard; Susanne Bremer; Klaus Becker
Preliminary results of the ECVAM validation study on three in vitro embryotoxicity tests.
Alternatives to laboratory animals : ATLA 2001;29(3):301-3.
2000: Aldert H Piersma; Aart Verhoef; J D te Biesebeek; Moniek N Pieters; Wout Slob
Developmental toxicity of butyl benzyl phthalate in the rat using a multiple dose study design.
Reproductive toxicology (Elmsford, N.Y.) 2000;14(5):417-25.
2000: M E Beekhuijzen; Aart Verhoef; R Klaassen; C J Rompelberg; Aldert H Piersma
Comparison of in vitro and in vivo developmental toxicity and pharmacokinetics of phenytoin in the rat.
Pharmacology & toxicology 2000;87(2):96-102.
2000: Elke Genschow; Gabriele Scholz; N Brown; Aldert H Piersma; Madeleine Brady; Nicole Clemann; Hannele Huuskonen; Francoise Paillard; Susanne Bremer; Klaus Becker; Horst Spielmann
Development of prediction models for three in vitro embryotoxicity tests in an ECVAM validation study.
In vitro & molecular toxicology 2000;13(1):51-66.
1998: Aldert H Piersma; Aart Verhoef; Antoon Opperhuizen; R Klaassen; Jan C H van Eijkeren; M Olling
Embryotoxicity of carbamazepine in rat postimplantation embryo culture after in vitro exposure via three different routes.
Reproductive toxicology (Elmsford, N.Y.) 1998;12(2):161-8.
1993: Aldert H Piersma
Whole embryo culture and toxicity testing.
Toxicology in vitro : an international journal published in association with BIBRA 1993;7(6):763-8.
1993: Aldert H Piersma; A S Haakmat; A M Hagenaars
In vitro assays for the developmental toxicity of xenobiotic compounds using differentiating embryonal carcinoma cells in culture.
Toxicology in vitro : an international journal published in association with BIBRA 1993;7(5):615-21.
1992: P W Peters; Aldert H Piersma
Rejoinder.
Toxicology in vitro : an international journal published in association with BIBRA 1992;6(2):179.
1991: Aldert H Piersma; Aart Verhoef; P W Peters
Effects of low sodium concentrations on the development of post-implantation rat embryos in culture and on their sensitivity to anticonvulsants.
Toxicology in vitro : an international journal published in association with BIBRA 1991;5(1):71-5.
1990: P W Peters; Aldert H Piersma
In vitro embryotoxicity and teratogenicity studies.
Toxicology in vitro : an international journal published in association with BIBRA 1990;4(4-5):570-6.