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Marko Pietilä

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Marko Pietilä; Anita Lampinen; Riikka Pellinen; Leena Alhonen
Inducible expression of antizyme 1 in prostate cancer cell lines after lentivirus mediated gene transfer.
Marc Cerrada-Gimenez; Marko Pietilä; Suvikki Loimas; Eija Pirinen; Mervi T Hyvönen; Tuomo A Keinänen; Juhani Jänne; Leena Alhonen
Continuous oxidative stress due to activation of polyamine catabolism accelerates aging and protects against hepatotoxic insults.
Susanna Vuohelainen; Eija Pirinen; Marc Cerrada-Gimenez; Tuomo A Keinänen; Anne Uimari; Marko Pietilä; Alex R Khomutov; Juhani Jänne; Leena Alhonen
Spermidine is indispensable in differentiation of 3T3-L1 fibroblasts to adipocytes.

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All Publications

2012: Marko Pietilä; Anita Lampinen; Riikka Pellinen; Leena Alhonen
Inducible expression of antizyme 1 in prostate cancer cell lines after lentivirus mediated gene transfer.
Amino acids 2012;42(2-3):559-64.
2011: Marc Cerrada-Gimenez; Marko Pietilä; Suvikki Loimas; Eija Pirinen; Mervi T Hyvönen; Tuomo A Keinänen; Juhani Jänne; Leena Alhonen
Continuous oxidative stress due to activation of polyamine catabolism accelerates aging and protects against hepatotoxic insults.
Transgenic research 2011;20(2):387-96.
2010: Susanna Vuohelainen; Eija Pirinen; Marc Cerrada-Gimenez; Tuomo A Keinänen; Anne Uimari; Marko Pietilä; Alex R Khomutov; Juhani Jänne; Leena Alhonen
Spermidine is indispensable in differentiation of 3T3-L1 fibroblasts to adipocytes.
Journal of cellular and molecular medicine 2010;14(6B):1683-92.
2010: Eija Pirinen; Helena Gylling; Paula Itkonen; Nagendra Yaluri; Sami Heikkinen; Marko Pietilä; Teemu Kuulasmaa; Maija Tusa; Marc Cerrada-Gimenez; Jussi Pihlajamäki; Leena Alhonen; Juhani Jänne; Tatu A Miettinen; Markku Laakso
Activated polyamine catabolism leads to low cholesterol levels by enhancing bile acid synthesis.
Amino acids 2010;38(2):549-60.
2010: Tekele Markos Fashe; Tuomo A Keinänen; Nikolay Grigorenko; Alex R Khomutov; Juhani Jänne; Leena Alhonen; Marko Pietilä
Cutaneous application of alpha-methylspermidine activates the growth of resting hair follicles in mice.
Amino acids 2010;38(2):583-90.
2009: Leena Alhonen; Anne Uimari; Marko Pietilä; Mervi T Hyvönen; Eija Pirinen; Tuomo A Keinänen
Transgenic animals modelling polyamine metabolism-related diseases.
Essays in biochemistry 2009;46():125-44.
2007: M Merentie; Anne Uimari; Marko Pietilä; Riitta Sinervirta; Tuomo A Keinänen; Jouko Vepsäläinen; Alex R Khomutov; Nikolay Grigorenko; Karl-Heinz Herzig; Juhani Jänne; Leena Alhonen
Oxidative stress and inflammation in the pathogenesis of activated polyamine catabolism-induced acute pancreatitis.
Amino acids 2007;33(2):323-30.
2007: Eija Pirinen; Tiina Kuulasmaa; Marko Pietilä; Sami Heikkinen; Maija Tusa; Paula Itkonen; Susanna Boman; Joanna Skommer; Antti Virkamäki; Esa Hohtola; Mikko I Kettunen; Szabolcs Fatrai; Emilia Kansanen; Suvi Koota; Kirsi Niiranen; Jyrki Parkkinen; Anna-Liisa Levonen; Seppo Ylä-Herttuala; J Kalervo Hiltunen; Leena Alhonen; Ulf Smith; Juhani Jänne; Markku Laakso
Enhanced polyamine catabolism alters homeostatic control of white adipose tissue mass, energy expenditure, and glucose metabolism.
Molecular and cellular biology 2007;27(13):4953-67.
2006: Kirsi Niiranen; Tuomo A Keinänen; Eija Pirinen; Sami Heikkinen; Maija Tusa; Szabolcs Fatrai; Suvikki Suppola; Marko Pietilä; Anne Uimari; Markku Laakso; Leena Alhonen; Juhani Jänne
Mice with targeted disruption of spermidine/spermine N1-acetyltransferase gene maintain nearly normal tissue polyamine homeostasis but show signs of insulin resistance upon aging.
Journal of cellular and molecular medicine 2006;10(4):933-45.
2006: Juhani Jänne; Leena Alhonen; Marko Pietilä; Tuomo A Keinänen; Anne Uimari; Mervi T Hyvönen; Eija Pirinen; Aki Järvinen
Genetic manipulation of polyamine catabolism in rodents.
Journal of biochemistry 2006;139(2):155-60.
2005: Juhani Jänne; Leena Alhonen; Tuomo A Keinänen; Marko Pietilä; Anne Uimari; Eija Pirinen; Mervi T Hyvönen; Aki Järvinen
Animal disease models generated by genetic engineering of polyamine metabolism.
Journal of cellular and molecular medicine 2005;9(4):865-82.
2005: Marko Pietilä; Eija Pirinen; Salla Keskitalo; Sisko Juutinen; Sanna Pasonen-Seppänen; Tuomo A Keinänen; Leena Alhonen; Juhani Jänne
Disturbed keratinocyte differentiation in transgenic mice and organotypic keratinocyte cultures as a result of spermidine/spermine N-acetyltransferase overexpression.
The Journal of investigative dermatology 2005;124(3):596-601.
2004: Juhani Jänne; Leena Alhonen; Marko Pietilä; Tuomo A Keinänen
Genetic approaches to the cellular functions of polyamines in mammals.
European journal of biochemistry / FEBS 2004;271(5):877-94.
2002: Kirsi Niiranen; Marko Pietilä; Tuula Pirttilä; Aki Järvinen; Maria Halmekytö; Veli-Pekka Korhonen; Tuomo A Keinänen; Leena Alhonen; Juhani Jänne
Targeted disruption of spermidine/spermine N1-acetyltransferase gene in mouse embryonic stem cells. Effects on polyamine homeostasis and sensitivity to polyamine analogues.
The Journal of biological chemistry 2002;277(28):25323-8.
2002: Leena Alhonen; Tiina-Liisa Räsänen; Riitta Sinervirta; Jyrki Parkkinen; Veli-Pekka Korhonen; Marko Pietilä; Juhani Jänne
Polyamines are required for the initiation of rat liver regeneration.
The Biochemical journal 2002;362(Pt 1):149-53.
2001: Marko Pietilä; Jyrki Parkkinen; Leena Alhonen; Juhani Jänne
Relation of skin polyamines to the hairless phenotype in transgenic mice overexpressing spermidine/spermine N-acetyltransferase.
The Journal of investigative dermatology 2001;116(5):801-5.
2001: Veli-Pekka Korhonen; Kirsi Niiranen; Maria Halmekytö; Marko Pietilä; Paula Diegelman; Jyrki Parkkinen; T Eloranta; Carl W Porter; Leena Alhonen; Juhani Jänne
Spermine deficiency resulting from targeted disruption of the spermine synthase gene in embryonic stem cells leads to enhanced sensitivity to antiproliferative drugs.
Molecular pharmacology 2001;59(2):231-8.
1999: Sami Heikkinen; Marko Pietilä; Maria Halmekytö; Suvikki Suppola; Eija Pirinen; Samir S Deeb; Juhani Jänne; Markku Laakso
Hexokinase II-deficient mice. Prenatal death of homozygotes without disturbances in glucose tolerance in heterozygotes.
The Journal of biological chemistry 1999;274(32):22517-23.
1999: Leena Alhonen; Marko Pietilä; Maria Halmekytö; Debora L Kramer; Juhani Jänne; Carl W Porter
Transgenic mice with activated polyamine catabolism due to overexpression of spermidine/spermine N1-acetyltransferase show enhanced sensitivity to the polyamine analog, N1, N11-diethylnorspermine.
Molecular pharmacology 1999;55(4):693-8.
1999: Suvikki Suppola; Marko Pietilä; Jyrki Parkkinen; Veli-Pekka Korhonen; Leena Alhonen; Maria Halmekytö; Carl W Porter; Juhani Jänne
Overexpression of spermidine/spermine N1-acetyltransferase under the control of mouse metallothionein I promoter in transgenic mice: evidence for a striking post-transcriptional regulation of transgene expression by a polyamine analogue.
The Biochemical journal 1999;338 ( Pt 2)():311-6.
1997: Marko Pietilä; Leena Alhonen; Maria Halmekytö; P Kanter; Juhani Jänne; Carl W Porter
Activation of polyamine catabolism profoundly alters tissue polyamine pools and affects hair growth and female fertility in transgenic mice overexpressing spermidine/spermine N1-acetyltransferase.
The Journal of biological chemistry 1997;272(30):18746-51.