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Christian Pike

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Anna M Barron; Donatella Caruso; Luis M Garcia-Segura; Anusha Jayaraman; Joo-Won Lee; Roberto C Melcangi; Christian J Pike
Ligand for translocator protein reverses pathology in a mouse model of Alzheimer's disease.
Rebekah S Vest; Christian J Pike
Gender, sex steroid hormones, and Alzheimer's disease.
Anusha Jayaraman; Sharon Lin; Todd E Morgan; M Paul Murphy; Jason M Arimoto; Tina L Beckett; Roberta Diaz Brinton; Jenna C Carroll; Caleb E Finch; Liqin Zhao; Christian J Pike
17β-estradiol and progesterone regulate expression of β-amyloid clearance factors in primary neuron cultures and female rat brain.

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All Publications

2013: Anna M Barron; Donatella Caruso; Luis M Garcia-Segura; Anusha Jayaraman; Joo-Won Lee; Roberto C Melcangi; Christian J Pike
Ligand for translocator protein reverses pathology in a mouse model of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013;33(20):8891-7.
2013: Rebekah S Vest; Christian J Pike
Gender, sex steroid hormones, and Alzheimer's disease.
Hormones and behavior 2013;63(2):301-7.
2012: Anusha Jayaraman; Sharon Lin; Todd E Morgan; M Paul Murphy; Jason M Arimoto; Tina L Beckett; Roberta Diaz Brinton; Jenna C Carroll; Caleb E Finch; Liqin Zhao; Christian J Pike
17β-estradiol and progesterone regulate expression of β-amyloid clearance factors in primary neuron cultures and female rat brain.
Endocrinology 2012;153(11):5467-79.
2012: Daijun Ling; Christian J Pike; Paul M Salvaterra
Deconvolution of the confounding variations for reverse transcription quantitative real-time polymerase chain reaction by separate analysis of biological replicate data.
Analytical biochemistry 2012;427(1):21-5.
2012: Emily R Rosario; Jenna C Carroll; Christian J Pike
Evaluation of the effects of testosterone and luteinizing hormone on regulation of β-amyloid in male 3xTg-AD mice.
Brain research 2012;1466():137-45.
2012: Radha Aras; Anna M Barron; Christian J Pike
Caspase activation contributes to astrogliosis.
Brain research 2012;1450():102-15.
2012: Liqin Zhao; Enrique Cadenas; Caleb E Finch; Sharon Lin; Wendy J Mack; Zisu Mao; Todd E Morgan; Christian J Pike; Roberta Diaz Brinton
Continuous versus cyclic progesterone exposure differentially regulates hippocampal gene expression and functional profiles.
PloS one 2012;7(2):e31267.
2011: Emily R Rosario; Lilly Chang; Elizabeth Head; Frank Z Stanczyk; Christian J Pike
Brain levels of sex steroid hormones in men and women during normal aging and in Alzheimer's disease.
Neurobiology of aging 2011;32(4):604-13.
2010: Jenna C Carroll; Emily R Rosario; Sara Kreimer; Angela Villamagna; Elisabet Gentzschein; Frank Z Stanczyk; Christian J Pike
Sex differences in β-amyloid accumulation in 3xTg-AD mice: role of neonatal sex steroid hormone exposure.
Brain research 2010;1366():233-45.
2010: T V Nguyen; A Jayaraman; A Quaglino; Christian J Pike
Androgens selectively protect against apoptosis in hippocampal neurones.
Journal of neuroendocrinology 2010;22(9):1013-22.
2010: Jenna C Carroll; Emily R Rosario; Angela Villamagna; Christian J Pike
Continuous and cyclic progesterone differentially interact with estradiol in the regulation of Alzheimer-like pathology in female 3xTransgenic-Alzheimer's disease mice.
Endocrinology 2010;151(6):2713-22.
2009: Emily R Rosario; Lilly Chang; Tina L Beckett; Jenna C Carroll; M Paul Murphy; Frank Z Stanczyk; Christian J Pike
Age-related changes in serum and brain levels of androgens in male Brown Norway rats.
Neuroreport 2009;20(17):1534-7.
2009: Thuy-Vi V Nguyen; Mingzhong Yao; Christian J Pike
Dihydrotestosterone activates CREB signaling in cultured hippocampal neurons.
Brain research 2009;1298():1-12.
2009: Christian J Pike; Jenna C Carroll; Emily R Rosario; Anna M Barron
Protective actions of sex steroid hormones in Alzheimer's disease.
Frontiers in neuroendocrinology 2009;30(2):239-58.
2009: A Jayaraman; Christian J Pike
Progesterone attenuates oestrogen neuroprotection via downregulation of oestrogen receptor expression in cultured neurones.
Journal of neuroendocrinology 2009;21(1):77-81.
2008: Jenna C Carroll; Emily R Rosario; Christian J Pike
Progesterone blocks estrogen neuroprotection from kainate in middle-aged female rats.
Neuroscience letters 2008;445(3):229-32.
2008: Mingzhong Yao; Thuy-Vi V Nguyen; Emily R Rosario; Martin Ramsden; Christian J Pike
Androgens regulate neprilysin expression: role in reducing beta-amyloid levels.
Journal of neurochemistry 2008;105(6):2477-88.
2008: Roberta Diaz Brinton; Richard F Thompson; Michael R Foy; Michel Baudry; Jun Ming Wang; Caleb E Finch; Todd E Morgan; Christian J Pike; Wendy Mack; Frank Z Stanczyk; Jon Nilsen
Progesterone receptors: form and function in brain.
Frontiers in neuroendocrinology 2008;29(2):313-39.
2008: Jenna C Carroll; Christian J Pike
Selective estrogen receptor modulators differentially regulate Alzheimer-like changes in female 3xTg-AD mice.
Endocrinology 2008;149(5):2607-11.
2008: Christian J Pike; Thuy-Vi V Nguyen; Martin Ramsden; Mingzhong Yao; Michael Murphy; Emily R Rosario
Androgen cell signaling pathways involved in neuroprotective actions.
Hormones and behavior 2008;53(5):693-705.
2008: Emily R Rosario; Christian J Pike
Androgen regulation of beta-amyloid protein and the risk of Alzheimer's disease.
Brain research reviews 2008;57(2):444-53.
2007: Jenna C Carroll; Emily R Rosario; Lilly Chang; Frank Z Stanczyk; Salvatore Oddo; Frank M LaFerla; Christian J Pike
Progesterone and estrogen regulate Alzheimer-like neuropathology in female 3xTg-AD mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(48):13357-65.
2007: Thuy-Vi V Nguyen; Mingzhong Yao; Christian J Pike
Flutamide and cyproterone acetate exert agonist effects: induction of androgen receptor-dependent neuroprotection.
Endocrinology 2007;148(6):2936-43.
2007: Mingzhong Yao; Thuy-Vi V Nguyen; Christian J Pike
Estrogen regulates Bcl-w and Bim expression: role in protection against beta-amyloid peptide-induced neuronal death.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(6):1422-33.
2007: Michael J Chen; T V Nguyen; Christian J Pike; Amelia A Russo-Neustadt
Norepinephrine induces BDNF and activates the PI-3K and MAPK cascades in embryonic hippocampal neurons.
Cellular signalling 2007;19(1):114-28.
2006: Emily R Rosario; Jenna C Carroll; Salvatore Oddo; Frank M LaFerla; Christian J Pike
Androgens regulate the development of neuropathology in a triple transgenic mouse model of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(51):13384-9.
2006: Emily R Rosario; Martin Ramsden; Christian J Pike
Progestins inhibit the neuroprotective effects of estrogen in rat hippocampus.
Brain research 2006;1099(1):206-10.
2006: Christian J Pike; Emily R Rosario; Thuy-Vi V Nguyen
Androgens, aging, and Alzheimer's disease.
Endocrine 2006;29(2):233-41.
2006: Myriam Cordey; Christian J Pike
Conventional protein kinase C isoforms mediate neuroprotection induced by phorbol ester and estrogen.
Journal of neurochemistry 2006;96(1):204-17.
2005: Thuy-Vi V Nguyen; Mingzhong Yao; Christian J Pike
Androgens activate mitogen-activated protein kinase signaling: role in neuroprotection.
Journal of neurochemistry 2005;94(6):1639-51.
2005: Myriam Cordey; Usha Gundimeda; Rayudu Gopalakrishna; Christian J Pike
The synthetic estrogen 4-estren-3 alpha,17 beta-diol (estren) induces estrogen-like neuroprotection.
Neurobiology of disease 2005;19(1-2):331-9.
2005: Myriam Cordey; Christian J Pike
Neuroprotective properties of selective estrogen receptor agonists in cultured neurons.
Brain research 2005;1045(1-2):217-23.
2005: Mingzhong Yao; Thuy-Vi V Nguyen; Christian J Pike
Beta-amyloid-induced neuronal apoptosis involves c-Jun N-terminal kinase-dependent downregulation of Bcl-w.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(5):1149-58.
2004: Emily R Rosario; Lilly Chang; Frank Z Stanczyk; Christian J Pike
Age-related testosterone depletion and the development of Alzheimer disease.
JAMA : the journal of the American Medical Association 2004;292(12):1431-2.
2003: Martin Ramsden; Andrew C Nyborg; Michael Murphy; Lilly Chang; Frank Z Stanczyk; todd golde; Christian J Pike
Androgens modulate beta-amyloid levels in male rat brain.
Journal of neurochemistry 2003;87(4):1052-5.
2003: Martin Ramsden; Nicole C Berchtold; J Patrick Kesslak; Carl W Cotman; Christian J Pike
Exercise increases the vulnerability of rat hippocampal neurons to kainate lesion.
Brain research 2003;971(2):239-44.
2003: Myriam Cordey; Usha Gundimeda; Rayudu Gopalakrishna; Christian J Pike
Estrogen activates protein kinase C in neurons: role in neuroprotection.
Journal of neurochemistry 2003;84(6):1340-8.
2003: Martin Ramsden; T M Shin; Christian J Pike
Androgens modulate neuronal vulnerability to kainate lesion.
Neuroscience 2003;122(3):573-8.
2002: Brian A Soreghan; Christian J Pike; Rakez Kayed; Wenquiang Tian; Saskia Milton; Carl W Cotman; Charles G Glabe
The influence of the carboxyl terminus of the Alzheimer Abeta peptide on its conformation, aggregation, and neurotoxic properties.
Neuromolecular medicine 2002;1(1):81-94.
2001: Nicole C Berchtold; J Patrick Kesslak; Christian J Pike; Paul A Adlard; Carl W Cotman
Estrogen and exercise interact to regulate brain-derived neurotrophic factor mRNA and protein expression in the hippocampus.
The European journal of neuroscience 2001;14(12):1992-2002.
2001: Christian J Pike
Testosterone attenuates beta-amyloid toxicity in cultured hippocampal neurons.
Brain research 2001;919(1):160-5.
2001: S E Stoltzner; Nicole C Berchtold; Carl W Cotman; Christian J Pike
Estrogen regulates bcl-x expression in rat hippocampus.
Neuroreport 2001;12(13):2797-800.
1999: Christian J Pike
Estrogen modulates neuronal Bcl-xL expression and beta-amyloid-induced apoptosis: relevance to Alzheimer's disease.
Journal of neurochemistry 1999;72(4):1552-63.
1997: Christian J Pike; N Ramezan-Arab; Carl W Cotman
Beta-amyloid neurotoxicity in vitro: evidence of oxidative stress but not protection by antioxidants.
Journal of neurochemistry 1997;69(4):1601-11.
1997: FM Donovan; Christian J Pike; Carl W Cotman; Dennis D Cunningham
Thrombin induces apoptosis in cultured neurons and astrocytes via a pathway requiring tyrosine kinase and RhoA activities.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(14):5316-26.
1997: David H Cribbs; Christian J Pike; S L Weinstein; Peter Velazquez; Carl W Cotman
All-D-enantiomers of beta-amyloid exhibit similar biological properties to all-L-beta-amyloids.
The Journal of biological chemistry 1997;272(11):7431-6.
1996: G Deng; Christian J Pike; Carl W Cotman
Alzheimer-associated presenilin-2 confers increased sensitivity to apoptosis in PC12 cells.
FEBS letters 1996;397(1):50-4.
1996: Brian John Cummings; Christian J Pike; R Shankle; Carl W Cotman
Beta-amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease.
Neurobiology of aging 1996;17(6):921-33.
1996: Christian J Pike; R Balázs; Carl W Cotman
Attenuation of beta-amyloid neurotoxicity in vitro by potassium-induced depolarization.
Journal of neurochemistry 1996;67(4):1774-7.
1996: Christian J Pike; N Ramezan-Arab; S Miller; Carl W Cotman
beta-Amyloid increases enzyme activity and protein levels of glutamine synthetase in cultured astrocytes.
Experimental neurology 1996;139(1):167-71.
1996: Christian J Pike; P J Vaughan; Dennis D Cunningham; Carl W Cotman
Thrombin attenuates neuronal cell death and modulates astrocyte reactivity induced by beta-amyloid in vitro.
Journal of neurochemistry 1996;66(4):1374-82.
1995: Christian J Pike; M J Overman; Carl W Cotman
Amino-terminal deletions enhance aggregation of beta-amyloid peptides in vitro.
The Journal of biological chemistry 1995;270(41):23895-8.
1995: A J Anderson; Christian J Pike; Carl W Cotman
Differential induction of immediate early gene proteins in cultured neurons by beta-amyloid (A beta): association of c-Jun with A beta-induced apoptosis.
Journal of neurochemistry 1995;65(4):1487-98.
1995: P J Vaughan; Christian J Pike; Carl W Cotman; Dennis D Cunningham
Thrombin receptor activation protects neurons and astrocytes from cell death produced by environmental insults.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(7 Pt 2):5389-401.
1995: Christian J Pike; Brian John Cummings; Carl W Cotman
Early association of reactive astrocytes with senile plaques in Alzheimer's disease.
Experimental neurology 1995;132(2):172-9.
1995: Christian J Pike; Carl W Cotman
Calretinin-immunoreactive neurons are resistant to beta-amyloid toxicity in vitro.
Brain research 1995;671(2):293-8.
1995: Christian J Pike; A J Walencewicz-Wasserman; J Kosmoski; David H Cribbs; Charles G Glabe; Carl W Cotman
Structure-activity analyses of beta-amyloid peptides: contributions of the beta 25-35 region to aggregation and neurotoxicity.
Journal of neurochemistry 1995;64(1):253-65.
1994: Christian J Pike; Brian John Cummings; R Monzavi; Carl W Cotman
Beta-amyloid-induced changes in cultured astrocytes parallel reactive astrocytosis associated with senile plaques in Alzheimer's disease.
Neuroscience 1994;63(2):517-31.
1994: J A Watt; Christian J Pike; A J Walencewicz-Wasserman; Carl W Cotman
Ultrastructural analysis of beta-amyloid-induced apoptosis in cultured hippocampal neurons.
Brain research 1994;661(1-2):147-56.
1994: John H Weiss; Christian J Pike; Carl W Cotman
Ca2+ channel blockers attenuate beta-amyloid peptide toxicity to cortical neurons in culture.
Journal of neurochemistry 1994;62(1):372-5.
1993: David A Stenger; Christian J Pike; J J Hickman; Carl W Cotman
Surface determinants of neuronal survival and growth on self-assembled monolayers in culture.
Brain research 1993;630(1-2):136-47.
1993: A R Korotzer; Christian J Pike; Carl W Cotman
beta-Amyloid peptides induce degeneration of cultured rat microglia.
Brain research 1993;624(1-2):121-5.
1993: D T Loo; Agata Copani; Christian J Pike; Edward R Whittemore; A J Walencewicz; Carl W Cotman
Apoptosis is induced by beta-amyloid in cultured central nervous system neurons.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(17):7951-5.
1993: Christian J Pike; Carl W Cotman
Cultured GABA-immunoreactive neurons are resistant to toxicity induced by beta-amyloid.
Neuroscience 1993;56(2):269-74.
1993: Christian J Pike; D Burdick; A J Walencewicz; Charles G Glabe; Carl W Cotman
Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1993;13(4):1676-87.
1993: Carl W Cotman; Christian J Pike; Brian John Cummings
Adaptive versus pathological plasticity. Possible contributions to age-related dementia.
Advances in neurology 1993;59():35-45.
1992: Carl W Cotman; Christian J Pike; Agata Copani
beta-Amyloid neurotoxicity: a discussion of in vitro findings.
Neurobiology of aging 1992;13(5):587-90.
1992: Christian J Pike; Brian John Cummings; Carl W Cotman
beta-Amyloid induces neuritic dystrophy in vitro: similarities with Alzheimer pathology.
Neuroreport 1992;3(9):769-72.
1991: Christian J Pike; A J Walencewicz; Charles G Glabe; Carl W Cotman
In vitro aging of beta-amyloid protein causes peptide aggregation and neurotoxicity.
Brain research 1991;563(1-2):311-4.
1991: Christian J Pike; A J Walencewicz; Charles G Glabe; Carl W Cotman
Aggregation-related toxicity of synthetic beta-amyloid protein in hippocampal cultures.
European journal of pharmacology 1991;207(4):367-8.