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Linda Pike

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TOP 3
Linda J Pike
Negative co-operativity in the EGF receptor.
Sangeeta Adak; Diana DeAndrade; Linda J Pike
The tethering arm of the EGF receptor is required for negative cooperativity and signal transduction.
Robert Y C Yang; Katherine S Yang; Linda J Pike; Garland R Marshall
Targeting the dimerization of epidermal growth factor receptors with small-molecule inhibitors.

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All Publications

2012: Linda J Pike
Negative co-operativity in the EGF receptor.
Biochemical Society transactions 2012;40(1):15-9.
2011: Sangeeta Adak; Diana DeAndrade; Linda J Pike
The tethering arm of the EGF receptor is required for negative cooperativity and signal transduction.
The Journal of biological chemistry 2011;286(2):1545-55.
2010: Robert Y C Yang; Katherine S Yang; Linda J Pike; Garland R Marshall
Targeting the dimerization of epidermal growth factor receptors with small-molecule inhibitors.
Chemical biology & drug design 2010;76(1):1-9.
2009: Jennifer L Macdonald-Obermann; Linda J Pike
The intracellular juxtamembrane domain of the epidermal growth factor (EGF) receptor is responsible for the allosteric regulation of EGF binding.
The Journal of biological chemistry 2009;284(20):13570-6.
2009: Jennifer L Macdonald-Obermann; Linda J Pike
Palmitoylation of the EGF receptor impairs signal transduction and abolishes high-affinity ligand binding.
Biochemistry 2009;48(11):2505-13.
2008: Jennifer L Macdonald; Linda J Pike
Heterogeneity in EGF-binding affinities arises from negative cooperativity in an aggregating system.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(1):112-7.
2006: Jennifer Macdonald; Zhengzhe Li; Wanwen Su; Linda J Pike
The membrane proximal disulfides of the EGF receptor extracellular domain are required for high affinity binding and signal transduction but do not play a role in the localization of the receptor to lipid rafts.
Biochimica et biophysica acta 2006;1763(8):870-8.
2006: Linda J Pike
Rafts defined: a report on the Keystone Symposium on Lipid Rafts and Cell Function.
Journal of lipid research 2006;47(7):1597-8.
2005: Linda J Pike; Xianlin Han; Richard W Gross
Epidermal growth factor receptors are localized to lipid rafts that contain a balance of inner and outer leaflet lipids: a shotgun lipidomics study.
The Journal of biological chemistry 2005;280(29):26796-804.
2005: Jennifer L Macdonald; Linda J Pike
A simplified method for the preparation of detergent-free lipid rafts.
Journal of lipid research 2005;46(5):1061-7.
2002: Linda J Pike; Laurieann Casey
Cholesterol levels modulate EGF receptor-mediated signaling by altering receptor function and trafficking.
Biochemistry 2002;41(32):10315-22.
2002: Linda J Pike; Xianlin Han; Koong-Nah Chung; Richard W Gross
Lipid rafts are enriched in arachidonic acid and plasmenylethanolamine and their composition is independent of caveolin-1 expression: a quantitative electrospray ionization/mass spectrometric analysis.
Biochemistry 2002;41(6):2075-88.
1998: Linda J Pike; J M Miller
Cholesterol depletion delocalizes phosphatidylinositol bisphosphate and inhibits hormone-stimulated phosphatidylinositol turnover.
The Journal of biological chemistry 1998;273(35):22298-304.
1998: Y Liu; L Casey; Linda J Pike
Compartmentalization of phosphatidylinositol 4,5-bisphosphate in low-density membrane domains in the absence of caveolin.
Biochemical and biophysical research communications 1998;245(3):684-90.
1997: S D Pandit; T O'Hare; H Donis-Keller; Linda J Pike
Functional characterization of an epidermal growth factor receptor/RET chimera.
The Journal of biological chemistry 1997;272(4):2199-206.
1996: Linda J Pike; L Casey
Localization and turnover of phosphatidylinositol 4,5-bisphosphate in caveolin-enriched membrane domains.
The Journal of biological chemistry 1996;271(43):26453-6.
1996: H R Hope; Linda J Pike
Phosphoinositides and phosphoinositide-utilizing enzymes in detergent-insoluble lipid domains.
Molecular biology of the cell 1996;7(6):843-51.
1996: S D Pandit; H Donis-Keller; T Iwamoto; J M Tomich; Linda J Pike
The multiple endocrine neoplasia type 2B point mutation alters long-term regulation and enhances the transforming capacity of the epidermal growth factor receptor.
The Journal of biological chemistry 1996;271(10):5850-8.
1995: E P Newberry; Linda J Pike
Cell-cycle-dependent modulation of EGF-receptor-mediated signaling.
Biochemical and biophysical research communications 1995;208(1):253-9.
1994: H M Hope; Linda J Pike
Purification and characterization of a polyphosphoinositide phosphatase from rat brain.
The Journal of biological chemistry 1994;269(38):23648-54.
1994: S M Schuh; E P Newberry; M A Dalton; Linda J Pike
Mutation of proline-1003 to glycine in the epidermal growth factor (EGF) receptor enhances responsiveness to EGF.
Molecular biology of the cell 1994;5(7):739-46.
1993: Dhandapani Kuppuswamy; M Dalton; Linda J Pike
Serine 1002 is a site of in vivo and in vitro phosphorylation of the epidermal growth factor receptor.
The Journal of biological chemistry 1993;268(25):19134-42.
1992: Linda J Pike
Phosphatidylinositol 4-kinases and the role of polyphosphoinositides in cellular regulation.
Endocrine reviews 1992;13(4):692-706.
1991: C Y Dadabay; E Patton; J A Cooper; Linda J Pike
Lack of correlation between changes in polyphosphoinositide levels and actin/gelsolin complexes in A431 cells treated with epidermal growth factor.
The Journal of cell biology 1991;112(6):1151-6.
1991: Dhandapani Kuppuswamy; Linda J Pike
Desensitization of the EGF receptor alters its ability to undergo EGF-induced dimerization.
Cellular signalling 1991;3(2):107-17.
1990: D H Walker; Linda J Pike
Stimulation of purified phosphatidylinositol 4-kinase by cobra venom cardiotoxin.
Biochimica et biophysica acta 1990;1055(3):295-8.
1989: C Y Dadabay; Linda J Pike
Purification and characterization of a cytosolic transglutaminase from a cultured human tumour-cell line.
The Biochemical journal 1989;264(3):679-85.
1989: T W Cunningham; Dhandapani Kuppuswamy; Linda J Pike
Treatment of A431 cells with epidermal growth factor (EGF) induces desensitization of EGF-stimulated phosphatidylinositol turnover.
The Journal of biological chemistry 1989;264(26):15351-6.
1989: Dhandapani Kuppuswamy; Linda J Pike
Ligand-induced desensitization of 125I-epidermal growth factor internalization.
The Journal of biological chemistry 1989;264(6):3357-63.
1987: D H Walker; Linda J Pike
Phosphatidylinositol kinase is activated in membranes derived from cells treated with epidermal growth factor.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(21):7513-7.
1987: C Y Dadabay; Linda J Pike
Rapid increases in the transglutaminase activity of A431 cells following treatment with epidermal growth factor.
Biochemistry 1987;26(21):6587-91.
1987: D H Walker; Dhandapani Kuppuswamy; A Visvanathan; Linda J Pike
Substrate specificity and kinetic mechanism of human placental insulin receptor/kinase.
Biochemistry 1987;26(5):1428-33.