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Irina Pikuleva

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TOP 3
Natalia Mast; Marlin Linger; Irina A Pikuleva
Inhibition and stimulation of activity of purified recombinant CYP11A1 by therapeutic agents.
Casey D Charvet; James Laird; Robert G Salomon; Yunfeng Xu; Irina A Pikuleva
Posttranslational modification by an isolevuglandin diminishes activity of the mitochondrial cytochrome P450 27A1.
Natalia Mast; C David Stout; Wenchao Zheng; Irina A Pikuleva
Binding of a cyano- and fluoro-containing drug bicalutamide to cytochrome P450 46A1: unusual features and spectral response.

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All Publications

2013: Natalia Mast; Marlin Linger; Irina A Pikuleva
Inhibition and stimulation of activity of purified recombinant CYP11A1 by therapeutic agents.
Molecular and cellular endocrinology 2013;371(1-2):100-6.
2013: Casey D Charvet; James Laird; Robert G Salomon; Yunfeng Xu; Irina A Pikuleva
Posttranslational modification by an isolevuglandin diminishes activity of the mitochondrial cytochrome P450 27A1.
Journal of lipid research 2013;54(5):1421-9.
2013: Natalia Mast; C David Stout; Wenchao Zheng; Irina A Pikuleva
Binding of a cyano- and fluoro-containing drug bicalutamide to cytochrome P450 46A1: unusual features and spectral response.
The Journal of biological chemistry 2013;288(7):4613-24.
2012: Natalia Mast; Matthew Clark; Marlin Linger; C David Stout; Jeffrey Wiseman; Irina A Pikuleva
In silico and intuitive predictions of CYP46A1 inhibition by marketed drugs with subsequent enzyme crystallization in complex with fluvoxamine.
Molecular pharmacology 2012;82(5):824-34.
2012: Saida Omarova; Neal S Peachey; Casey D Charvet; Suber Huang; Natalia Mast; Rachel E Reem; Wenchao Zheng; Irina A Pikuleva
Abnormal vascularization in mouse retina with dysregulated retinal cholesterol homeostasis.
The Journal of clinical investigation 2012;122(8):3012-23.
2012: Meiyao Wang; Gun-Young Heo; Saida Omarova; Irina A Pikuleva; Illarion V Turko
Sample prefractionation for mass spectrometry quantification of low-abundance membrane proteins.
Analytical chemistry 2012;84(12):5186-91.
2012: Gun-Young Heo; Wei-Li Liao; Illarion V Turko; Irina A Pikuleva
Features of the retinal environment which affect the activities and product profile of cholesterol-metabolizing cytochromes P450 CYP27A1 and CYP11A1.
Archives of biochemistry and biophysics 2012;518(2):119-26.
2012: Wenchao Zheng; Rachel E Reem; Casey D Charvet; Christine A Curcio; Pier Luigi DiPatre; Suber Huang; Saida Omarova; Irina A Pikuleva
Spatial distribution of the pathways of cholesterol homeostasis in human retina.
PloS one 2012;7(5):e37926.
2011: Casey Charvet; Wei-Li Liao; Gun-Young Heo; James Laird; Robert G Salomon; Illarion V Turko; Irina A Pikuleva
Isolevuglandins and mitochondrial enzymes in the retina: mass spectrometry detection of post-translational modification of sterol-metabolizing CYP27A1.
The Journal of biological chemistry 2011;286(23):20413-22.
2011: Gun-Young Heo; Ilya Bederman; Natalia Mast; Wei-Li Liao; Illarion V Turko; Irina A Pikuleva
Conversion of 7-ketocholesterol to oxysterol metabolites by recombinant CYP27A1 and retinal pigment epithelial cells.
Journal of lipid research 2011;52(6):1117-27.
2011: Marjan Shafaati; Amelia Marutle; Hanna Pettersson; Anita Lövgren-Sandblom; Maria Olin; Irina A Pikuleva; Bengt Winblad; agneta nordberg; Ingemar Björkhem
Marked accumulation of 27-hydroxycholesterol in the brains of Alzheimer's patients with the Swedish APP 670/671 mutation.
Journal of lipid research 2011;52(5):1004-10.
2011: Natalia Mast; Andrew J Annalora; David T Lodowski; Krzysztof Palczewski; C David Stout; Irina A Pikuleva
Structural basis for three-step sequential catalysis by the cholesterol side chain cleavage enzyme CYP11A1.
The Journal of biological chemistry 2011;286(7):5607-13.
2011: Wei-Li Liao; Gun-Young Heo; Nathan G Dodder; Rachel E Reem; Natalia Mast; Suber Huang; Pier Luigi Dipatre; Illarion V Turko; Irina A Pikuleva
Quantification of cholesterol-metabolizing P450s CYP27A1 and CYP46A1 in neural tissues reveals a lack of enzyme-product correlations in human retina but not human brain.
Journal of proteome research 2011;10(1):241-8.
2011: Natalia Mast; Rachel Reem; Ilya Bederman; Suber Huang; Pier Luigi DiPatre; Ingemar Bjorkhem; Irina A Pikuleva
Cholestenoic Acid is an important elimination product of cholesterol in the retina: comparison of retinal cholesterol metabolism with that in the brain.
Investigative ophthalmology & visual science 2011;52(1):594-603.
2010: Max D Driscoll; Kirsty J McLean; Colin Levy; Natalia Mast; Irina A Pikuleva; Pierre Lafite; Stephen E J Rigby; David Leys; Andrew W Munro
Structural and biochemical characterization of Mycobacterium tuberculosis CYP142: evidence for multiple cholesterol 27-hydroxylase activities in a human pathogen.
The Journal of biological chemistry 2010;285(49):38270-82.
2010: Natalia Mast; Casey Charvet; Irina A Pikuleva; C David Stout
Structural basis of drug binding to CYP46A1, an enzyme that controls cholesterol turnover in the brain.
The Journal of biological chemistry 2010;285(41):31783-95.
2010: Wei-Li Liao; Gun-Young Heo; Nathan G Dodder; Irina A Pikuleva; Illarion V Turko
Optimizing the conditions of a multiple reaction monitoring assay for membrane proteins: quantification of cytochrome P450 11A1 and adrenodoxin reductase in bovine adrenal cortex and retina.
Analytical chemistry 2010;82(13):5760-7.
2010: Natalia Mast; Marjan Shafaati; Wahiduz Zaman; Wenchao Zheng; Deborah Prusak; Thomas Wood; G A S Ansari; Anita Lövgren-Sandblom; Maria Olin; Ingemar Bjorkhem; Irina A Pikuleva
Marked variability in hepatic expression of cytochromes CYP7A1 and CYP27A1 as compared to cerebral CYP46A1. Lessons from a dietary study with omega 3 fatty acids in hamsters.
Biochimica et biophysica acta 2010;1801(6):674-81.
2010: Marjan Shafaati; Natalia Mast; Olof Beck; Rima Nayef; Gun Young Heo; Linda Björkhem-Bergman; Dieter Lütjohann; Ingemar Björkhem; Irina A Pikuleva
The antifungal drug voriconazole is an efficient inhibitor of brain cholesterol 24S-hydroxylase in vitro and in vivo.
Journal of lipid research 2010;51(2):318-23.
2009: Kirsty J McLean; Pierre Lafite; Colin Levy; Myles R Cheesman; Natalia Mast; Irina A Pikuleva; David Leys; Andrew W Munro
The Structure of Mycobacterium tuberculosis CYP125: molecular basis for cholesterol binding in a P450 needed for host infection.
The Journal of biological chemistry 2009;284(51):35524-33.
2009: Wei-Li Liao; Nathan G Dodder; Natalia Mast; Irina A Pikuleva; Illarion V Turko
Steroid and protein ligand binding to cytochrome P450 46A1 as assessed by hydrogen-deuterium exchange and mass spectrometry.
Biochemistry 2009;48(19):4150-8.
2009: Natalia Mast; Wei-Li Liao; Irina A Pikuleva; Illarion V Turko
Combined use of mass spectrometry and heterologous expression for identification of membrane-interacting peptides in cytochrome P450 46A1 and NADPH-cytochrome P450 oxidoreductase.
Archives of biochemistry and biophysics 2009;483(1):81-9.
2008: Irina A Pikuleva; Natalia Mast; Wei-Li Liao; Illarion V Turko
Studies of membrane topology of mitochondrial cholesterol hydroxylases CYPs 27A1 and 11A1.
Lipids 2008;43(12):1127-32.
2008: Irina A Pikuleva
Cholesterol-metabolizing cytochromes P450: implications for cholesterol lowering.
Expert opinion on drug metabolism & toxicology 2008;4(11):1403-14.
2008: Natalia Mast; Mark A White; Ingemar Bjorkhem; Eric F Johnson; C David Stout; Irina A Pikuleva
Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(28):9546-51.
2008: Mark Andrew White; Natalia Mast; Ingemar Bjorkhem; Eric F Johnson; C David Stout; Irina A Pikuleva
Use of complementary cation and anion heavy-atom salt derivatives to solve the structure of cytochrome P450 46A1.
Acta crystallographica. Section D, Biological crystallography 2008;64(Pt 5):487-95.
2007: Meaney Steve; Maura Heverin; Ute Panzenboeck; Lena Ekström; Magnus Axelsson; Ulla Andersson; Ulf Diczfalusy; Irina A Pikuleva; John Wahren; Wolfgang Sattler; Ingemar Björkhem
Novel route for elimination of brain oxysterols across the blood-brain barrier: conversion into 7alpha-hydroxy-3-oxo-4-cholestenoic acid.
Journal of lipid research 2007;48(4):944-51.
2006: Irina A Pikuleva
Cytochrome P450s and cholesterol homeostasis.
Pharmacology & therapeutics 2006;112(3):761-73.
2006: Natalia Mast; Dilyara A Murtazina; Hong Liu; Sandra E Graham; Ingemar Bjorkhem; James Halpert; Julian Peterson; Irina A Pikuleva
Distinct binding of cholesterol and 5beta-cholestane-3alpha,7alpha,12alpha-triol to cytochrome P450 27A1: evidence from modeling and site-directed mutagenesis studies.
Biochemistry 2006;45(14):4396-404.
2006: Irina A Pikuleva
Cholesterol-metabolizing cytochromes P450.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(4):513-20.
2005: Natalia Mast; Irina A Pikuleva
A simple and rapid method to measure cholesterol binding to P450s and other proteins.
Journal of lipid research 2005;46(7):1561-8.
2005: Natalia Mast; Sandra E Graham; Ulla Andersson; Ingemar Bjorkhem; Courtney Hill; Julian Peterson; Irina A Pikuleva
Cholesterol binding to cytochrome P450 7A1, a key enzyme in bile acid biosynthesis.
Biochemistry 2005;44(9):3259-71.
2004: Dilyara A Murtazina; Ulla Andersson; In-Su Hahn; Ingemar Bjorkhem; G A S Ansari; Irina A Pikuleva
Phospholipids modify substrate binding and enzyme activity of human cytochrome P450 27A1.
Journal of lipid research 2004;45(12):2345-53.
2004: Natalia Mast; Ulla Andersson; Kazuo Nakayama; Ingemar Bjorkhem; Irina A Pikuleva
Expression of human cytochrome P450 46A1 in Escherichia coli: effects of N- and C-terminal modifications.
Archives of biochemistry and biophysics 2004;428(1):99-108.
2004: Irina A Pikuleva
Putative F-G loop is involved in association with the membrane in P450scc (P450 11A1).
Molecular and cellular endocrinology 2004;215(1-2):161-4.
2004: Maura Heverin; Nenad Bogdanovic; Dieter Lütjohann; Thomas Bayer; Irina A Pikuleva; Lionel Bretillon; Ulf Diczfalusy; Bengt Winblad; Ingemar Björkhem
Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease.
Journal of lipid research 2004;45(1):186-93.
2003: Natalia Mast; Ryan Norcross; Ulla Andersson; Magang Shou; Kazuo Nakayama; Ingemar Bjorkhem; Irina A Pikuleva
Broad substrate specificity of human cytochrome P450 46A1 which initiates cholesterol degradation in the brain.
Biochemistry 2003;42(48):14284-92.
2003: Irina A Pikuleva; Norman B Javitt
Novel sterols synthesized via the CYP27A1 metabolic pathway.
Archives of biochemistry and biophysics 2003;420(1):35-9.
2002: Dilyara A Murtazina; Andrei V Puchkaev; Catherine H Schein; Numan Oezguen; Werner Braun; Amit Nanavati; Irina A Pikuleva
Membrane-protein interactions contribute to efficient 27-hydroxylation of cholesterol by mitochondrial cytochrome P450 27A1.
The Journal of biological chemistry 2002;277(40):37582-9.
2002: Karl Bodin; Ulla Andersson; Eva Rystedt; Ewa Ellis; Maria Norlin; Irina A Pikuleva; Gösta Eggertsen; Ingemar Björkhem; Ulf Diczfalusy
Metabolism of 4 beta -hydroxycholesterol in humans.
The Journal of biological chemistry 2002;277(35):31534-40.
2002: Sara von Bahr; Tomas Movin; Nikos Papadogiannakis; Irina A Pikuleva; Per Rönnow; Ulf Diczfalusy; Ingemar Björkhem
Mechanism of accumulation of cholesterol and cholestanol in tendons and the role of sterol 27-hydroxylase (CYP27A1).
Arteriosclerosis, thrombosis, and vascular biology 2002;22(7):1129-35.
2001: K Nakayama; Andrei V Puchkaev; Irina A Pikuleva
Membrane binding and substrate access merge in cytochrome P450 7A1, a key enzyme in degradation of cholesterol.
The Journal of biological chemistry 2001;276(33):31459-65.
2001: Irina A Pikuleva; Andrei V Puchkaev; Ingemar Björkhem
Putative helix F contributes to regioselectivity of hydroxylation in mitochondrial cytochrome P450 27A1.
Biochemistry 2001;40(25):7621-9.
2001: Ingemar Björkhem; L Starck; Ulla Andersson; Dieter Lütjohann; Sara von Bahr; Irina A Pikuleva; A Babiker; Ulf Diczfalusy
Oxysterols in the circulation of patients with the Smith-Lemli-Opitz syndrome: abnormal levels of 24S- and 27-hydroxycholesterol.
Journal of lipid research 2001;42(3):366-71.
2000: Irina A Pikuleva; K Tesh; Michael R Waterman; Y Kim
The tertiary structure of full-length bovine adrenodoxin suggests functional dimers.
Archives of biochemistry and biophysics 2000;373(1):44-55.
1999: Irina A Pikuleva; Carolyn Cao; Michael R Waterman
An additional electrostatic interaction between adrenodoxin and P450c27 (CYP27A1) results in tighter binding than between adrenodoxin and p450scc (CYP11A1).
The Journal of biological chemistry 1999;274(4):2045-52.
1998: Irina A Pikuleva; A Babiker; Michael R Waterman; Ingemar Björkhem
Activities of recombinant human cytochrome P450c27 (CYP27) which produce intermediates of alternative bile acid biosynthetic pathways.
The Journal of biological chemistry 1998;273(29):18153-60.
1998: CM Jenkins; Irina A Pikuleva; Michael R Waterman
Expression of eukaryotic cytochromes P450 in E. coli.
Methods in molecular biology (Clifton, N.J.) 1998;107():181-93.
1997: CM Jenkins; Irina A Pikuleva; Norio Kagawa; Michael R Waterman
Escherichia coli flavodoxin sepharose as an affinity resin for cytochromes P450 and use to identify a putative cytochrome P450c17/3beta-hydroxysteroid dehydrogenase interaction.
Archives of biochemistry and biophysics 1997;347(1):93-102.
1997: Irina A Pikuleva; Ingemar Björkhem; Michael R Waterman
Expression, purification, and enzymatic properties of recombinant human cytochrome P450c27 (CYP27).
Archives of biochemistry and biophysics 1997;343(1):123-30.
1996: Irina A Pikuleva; Ingemar Björkhem; Michael R Waterman
Studies of distant members of the P450 superfamily (P450scc and P450c27) by random chimeragenesis.
Archives of biochemistry and biophysics 1996;334(2):183-92.
1995: Michael R Waterman; CM Jenkins; Irina A Pikuleva
Genetically engineered bacterial cells and applications.
Toxicology letters 1995;82-83():807-13.
1995: Irina A Pikuleva; R L Mackman; Norio Kagawa; Michael R Waterman; Paul R. Ortiz de Montellano
Active-site topology of bovine cholesterol side-chain cleavage cytochrome P450 (P450scc) and evidence for interaction of tyrosine 94 with the side chain of cholesterol.
Archives of biochemistry and biophysics 1995;322(1):189-97.